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pmid:33188157
Development and validation of a novel prognostic signature in gastric adenocarcinoma.
Rui Mao · Zheng Wang · Yuanchuan Zhang · YuanYuan Chen · Qian Liu · Tongtong Zhang · Yanjun Liu
Aging · 2020 doi:10.18632/aging.104161
Paper
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Experiment
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Data
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Analysis
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Execution
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Complete file
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A ceRNA network was constructed based on the most relevant modules in the weighted gene coexpression network analysis. Kaplan-Meier (KM) survival analysis revealed prognosis-related RNAs, which were subjected to the multivariate Cox regression analysis. The predictive accuracy and discriminative ability of the signature were determined by KM analyses, receiver operating characteristic curves and area under the curve values. Ultimately, we constructed a ceRNA network consisting of 55 lncRNAs, 17 miRNAs and 73 mRNAs. Survival analyses revealed 3 lncRNAs (LINC01106, FOXD2-AS1, and AC103702.2) and 3 mRNAs (CCDC34, ORC6, and SOX4) as crucial prognostic factors; these factors were then used to construct a survival specific ceRNA network. Patients with high risk scores exhibited significantly worse overall survival than patients with low risk scores, and the AUC for 5-year survival was 0.801. 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