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pmid:33192072
Comprehensive Analysis of Aberrantly Expressed Competitive Endogenous RNA Network and Identification of Prognostic Biomarkers in Pheochromocytoma and Paraganglioma.
Zijun Wang · Yijian Li · Yanjun Zhong · Yinhuai Wang · Mou Peng
OncoTargets and therapy · 2020 doi:10.2147/OTT.S271417
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Complete file
{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:33192072", "kind": "science-record", "revision": 8, "content_hash": "sha256:87e1050a99d294f04ed8dcc6bd73b985204869277e35d6291dff508bace837e7", "created_at": "2026-11-01T15:41:15Z", "updated_at": "2026-11-01T22:45:36Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Comprehensive Analysis of Aberrantly Expressed Competitive Endogenous RNA Network and Identification of Prognostic Biomarkers in Pheochromocytoma and Paraganglioma.", "doi": "10.2147/OTT.S271417", "pmid": "33192072", "authors": ["Zijun Wang", "Yijian Li", "Yanjun Zhong", "Yinhuai Wang", "Mou Peng"], "journal": "OncoTargets and therapy", "year": 2020, "abstract": "BACKGROUND: Long non-coding RNA (lncRNA) functions as a competitive endogenous RNA (ceRNA) and plays an important role in the biological processes underlying tumorigenesis. However, studies describing the function of lncRNA in pheochromocytoma and paraganglioma (PCPG) remain largely unknown. Our study aims to construct a regulatory ceRNA network and explore prognostic biomarkers for PCPG through a comprehensive analysis.\nMETHODS: PCPG data from The Cancer Genome Atlas (TCGA) were utilized to obtain differentially expressed lncRNAs (DElncRNAs), microRNAs (DEmiRNAs), and mRNAs (DEmRNAs). Kaplan-Meier analysis was used to detect prognostic biomarkers and Cytoscape was utilized to construct a regulatory network of ceRNA. Potential lncRNA-miRNA-mRNA axes were inferred by correlation analysis. GO and KEGG pathways were constructed using \"clusterProfiler\" and \"DOSE\" R-packages. Immunohistochemistry (IHC) staining was performed to validate differential protein expression levels of genes in the axes. Finally, the GSE19422 dataset and Pan-Cancer data were applied to validate the expression pattern and survival status of mRNAs, respectively.\nRESULTS: A total of 334 DElncRNAs, 116 DEmiRNAs, and 3496 DEmRNAs were identified and mainly enriched in hormone secretion, metabolism signaling, metastatic and proliferative pathways. Among these differentially expressed genes, 16 mRNAs, six lncRNAs, and two miRNAs were associated with overall survival of patients with PCPG and sequentially enrolled in the ceRNA network. Two lncRNA-miRNA-mRNA regulatory axes were predicted: AP001486.2/hsa-miR-195-5p/RCAN3 and AP006333.2/hsa-miR-34a-5p/PTPRJ. The GSE19422 dataset and IHC analysis validated that mRNA and protein levels of RCAN3 and PTPRJ were upregulated in PCPG tissues compared with adjacent adrenal gland medulla tissues. Pan-Cancer data showed that the upregulated expression of RCAN3 and PTPRJ was associated with favorable overall survival and disease-free survival.\nCONCLUSION: A regulatory lncRNA-miRNA-mRNA ceRNA network was successfully constructed and 24 prognostic biomarkers were identified for PCPG patients. These findings may contribute toward a better understanding of the biological mechanism of tumorigenesis and enable further evaluation of the prognosis of patients with PCPG.", "claims": [{"id": "claim-method", "statement": "Differentially expressed genes were subsequently calculated by the “edgeR” package by comparing PCPG with normal adrenal gland tissue.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:33192072", "locator": "sections[3] \"RNA-Seq, miRNA Data, and Clinical Data from TCGA-PCPG\" paragraph 2", "quote": "Differentially expressed genes were subsequently calculated by the “edgeR” package by comparing PCPG with normal adrenal gland tissue."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The authors declare that the data supporting the findings of this study are available within the article.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:33192072", "locator": "sections[24] \"Data Sharing Statement\" paragraph 2", "quote": "The authors declare that the data supporting the findings of this study are available within the article."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": null, "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:33192072"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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"1.28E-05", "CNTNAP4", "6.819379", "0.016655", "0.047662"]], "row_count": 27, "column_count": 8, "numeric_cells": 166, "header_rows": 2, "locator": "section[13]/table-wrap[1]#t0001"}}, {"id": "asset:table:pmid:33192072:2", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:79e654e38782f4994d40000f9091956fe8e22a3b8398f5dfba29144a14b920a3", "bytes": 2682, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[13]/table-wrap[2]#t0002", "version": null, "note": "Top 25 Downregulated and Top 25 Upregulated lncRNA", "structure": {"pmcid": "PMC7654541", "section_index": 4, "section_title": "Identification of Differentially Expressed lncRNA, miRNA, and mRNA", "row_count": 27, "column_count": 8}, "table": {"label": "Table 2", "caption": "Top 25 Downregulated and Top 25 Upregulated lncRNA", "rows": [["Top 25 Downregulated lncRNA", "Top 25 Upregulated lncRNA"], ["Symbol", "logFC", "p-Value", "FDR", "Symbol", "logFC", "p-Value", "FDR"], ["AC073957.3", "−3.76797", "3.86E-17", "8.01E-15", "AC068700.1", "5.634188", "1.28E-11", "5.45E-10"], ["OIP5-AS1", "−1.56095", "5.60E-13", "3.50E-11", "AL022313.4", "5.727269", "1.34E-11", "5.64E-10"], ["ZNF503-AS2", "−3.251", "2.16E-11", "8.57E-10", "AL731557.1", "5.794468", "4.70E-10", "1.37E-08"], ["GSEC", "−2.11874", "2.36E-09", "5.80E-08", "AL390294.1", "6.21209", "5.81E-10", "1.66E-08"], ["DLGAP1-AS1", "−2.68487", "1.07E-08", "2.25E-07", "AL136964.1", "5.748429", "2.67E-09", "6.49E-08"], ["AC093157.1", "−1.71001", "6.11E-08", "1.06E-06", "AP002840.1", "6.246437", "6.31E-09", "1.40E-07"], ["AC026801.3", "−2.28817", "9.70E-08", "1.60E-06", "AL133163.3", "6.110686", "1.00E-08", "2.12E-07"], ["AL021453.1", "−2.33787", "1.08E-07", "1.75E-06", "AC105389.3", "6.985011", "2.29E-08", "4.46E-07"], ["AL354892.2", "−1.72175", "3.02E-07", "4.36E-06", "AC026369.1", "5.772437", "2.68E-08", "5.11E-07"], ["AC105942.1", "−1.90242", "7.62E-07", "9.82E-06", "MAPT-AS1", "7.141991", "1.39E-07", "2.20E-06"], ["AL445524.1", "−1.891", "1.44E-06", "1.72E-05", "AP006333.2", "7.895482", "1.75E-07", "2.68E-06"], ["LINC00174", "−1.54625", "5.17E-06", "5.27E-05", "LINC01930", "5.840071", "4.20E-07", "5.85E-06"], ["DANCR", "−1.64292", "5.70E-06", "5.73E-05", "LINC02287", "5.736795", "8.24E-07", "1.05E-05"], ["AC068888.1", "−1.69542", "1.11E-05", "0.000102", "AC010478.1", "5.881153", "1.23E-06", "1.50E-05"], ["NR2F1-AS1", "−2.24175", "1.84E-05", "0.000157", "AC005828.4", "6.087545", "4.65E-06", "4.79E-05"], ["MIR99AHG", "−2.2713", "2.05E-05", "0.000173", "LINC01982", "6.1136", "1.04E-05", "9.67E-05"], ["TMEM9B-AS1", "−1.60771", "5.64E-05", "0.000415", "UNC5B-AS1", "5.868469", "1.83E-05", "0.000156"], ["MIR22HG", "−1.56325", "0.000359", "0.002056", "KRTAP5-AS1", "5.581534", "2.19E-05", "0.000184"], ["ACVR2B-AS1", "−1.53248", "0.000457", "0.002526", "SATB1-AS1", "5.683773", "0.000118", "0.000785"], ["AC087741.1", "−1.88727", "0.000474", "0.002606", "GACAT2", "5.635535", "0.000123", "0.000808"], ["RNF144A-AS1", "−2.29893", "0.000715", "0.003684", "AC022893.2", "5.704634", "0.000135", "0.000878"], ["SH3BP5-AS1", "−1.66577", "0.000856", "0.004266", "AC079160.1", "6.192744", "0.000576", "0.003066"], ["CASC15", "−1.81374", "0.005303", "0.019168", "PP14571", "5.763316", "0.003315", "0.013082"], ["HOTAIRM1", "−1.59477", "0.007733", "0.025956", "AC010931.2", "6.202024", "0.005343", "0.019286"], ["AL365181.3", "−1.96367", "0.009386", "0.03028", "LINC00648", "5.741248", "0.008911", "0.029069"]], "row_count": 27, "column_count": 8, "numeric_cells": 188, "header_rows": 2, "locator": "section[13]/table-wrap[2]#t0002"}}, {"id": "asset:table:pmid:33192072:3", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:91ea0b959d0164a5b7c5c82f23b833738cd4409c009d23b50e4af53d642bdd48", "bytes": 3117, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[13]/table-wrap[3]#t0003", "version": null, "note": "Top 25 Downregulated and Top 25 Upregulated miRNA", "structure": {"pmcid": "PMC7654541", "section_index": 4, "section_title": "Identification of Differentially Expressed lncRNA, miRNA, and mRNA", "row_count": 27, "column_count": 8}, "table": {"label": "Table 3", "caption": "Top 25 Downregulated and Top 25 Upregulated miRNA", "rows": [["Top 25 Downregulated miRNA", "Top 25 Upregulated miRNA"], ["miRNA", "logFC", "p-Value", "FDR", "miRNA", "logFC", "p-Value", "FDR"], ["hsa-miR-193b-3p", "−4.57576", "3.27E-16", "1.57E-13", "hsa-miR-153-3p", "4.037745206", "8.05E-12", "7.73E-10"], ["hsa-miR-365a-3p", "−3.5141", "1.05E-15", "1.68E-13", "hsa-miR-153-5p", "3.876958022", "7.52E-07", "2.93E-05"], ["hsa-miR-365b-3p", "−3.51402", "1.05E-15", "1.68E-13", "hsa-miR-137", "3.474046104", "4.75E-06", "0.000134212"], ["hsa-miR-99a-5p", "−2.77945", "7.26E-12", "7.73E-10", "hsa-miR-7-5p", "4.09855618", "2.12E-05", "0.000484566"], ["hsa-let-7c-5p", "−2.5734", "3.80E-09", "3.04E-07", "hsa-miR-1179", "3.927385921", "0.000108253", "0.001791778"], ["hsa-miR-195-3p", "−2.45674", "8.70E-08", "5.22E-06", "hsa-miR-375", "4.391892691", "0.00015088", "0.002263197"], ["hsa-miR-195-5p", "−2.36364", "1.68E-07", "8.95E-06", "hsa-miR-483-5p", "4.509825699", "0.00029032", "0.003275823"], ["hsa-miR-497-5p", "−2.26742", "4.95E-07", "2.16E-05", "hsa-miR-2682-5p", "4.747525655", "0.000257548", "0.003275823"], ["hsa-miR-455-3p", "−2.6539", "1.11E-06", "3.79E-05", "hsa-miR-4705", "6.267096508", "0.000315449", "0.003424384"], ["hsa-miR-511-5p", "−2.68334", "3.73E-06", "0.000112", "hsa-miR-618", "6.118619944", "0.000366715", "0.003667154"], ["hsa-miR-424-5p", "−2.05804", "3.51E-05", "0.000732", "hsa-miR-129-1-3p", "5.291642562", "0.000388202", "0.003802792"], ["hsa-miR-199a-5p", "−2.12296", "4.31E-05", "0.000863", "hsa-miR-592", "5.405166969", "0.000603911", "0.005085565"], ["hsa-miR-450b-5p", "−2.36939", "6.82E-05", "0.00126", "hsa-miR-138-5p", "4.551885502", "0.000660335", "0.005282681"], ["hsa-miR-148a-5p", "−2.58608", "0.000136", "0.002172", "hsa-miR-483-3p", "5.369779777", "0.000971812", "0.006760433"], ["hsa-miR-100-5p", "−2.07348", "0.000239", "0.003193", "hsa-miR-410-5p", "4.258720479", "0.001106315", "0.007479313"], ["hsa-let-7c-3p", "−2.05432", "0.000261", "0.003276", "hsa-miR-873-5p", "6.897992073", "0.001176467", "0.007631138"], ["hsa-miR-508-3p", "−3.51777", "0.000358", "0.00366", "hsa-miR-138-1-3p", "6.836301551", "0.001554963", "0.009693277"], ["hsa-miR-214-5p", "−1.88088", "0.000516", "0.00459", "hsa-miR-196a-5p", "4.2097511", "0.002754991", "0.015199949"], ["hsa-miR-455-5p", "−2.1107", "0.001176", "0.007631", "hsa-miR-129-2-3p", "5.147195976", "0.003380698", "0.018232979"], ["hsa-miR-887-3p", "−2.03233", "0.00149", "0.009412", "hsa-miR-2682-3p", "3.882001702", "0.003507626", "0.018707336"], ["hsa-miR-450a-5p", "−2.05002", "0.001727", "0.010142", "hsa-miR-129-5p", "4.292125863", "0.00360147", "0.018996767"], ["hsa-miR-514a-3p", "−3.20846", "0.002123", "0.012133", "hsa-miR-3130-3p", "4.001109161", "0.00456375", "0.022993542"], ["hsa-miR-509-3p", "−3.00819", "0.005283", "0.025782", "hsa-miR-433-3p", "3.795466062", "0.006029191", "0.028372661"], ["hsa-miR-542-3p", "−1.91368", "0.005318", "0.025782", "hsa-miR-431-3p", "3.497554636", "0.007845611", "0.034235393"], ["hsa-miR-148a-3p", "−1.86422", "0.009125", "0.038422", "hsa-miR-541-3p", "4.102786131", "0.008572515", "0.037070335"]], "row_count": 27, "column_count": 8, "numeric_cells": 202, "header_rows": 2, "locator": "section[13]/table-wrap[3]#t0003"}}, {"id": "asset:table:pmid:33192072:4", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:ad6ba203c0a4a76fc5b1900f138b7d012f73a5689fb4ae5e5385b83e9957adbb", "bytes": 592, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[13]/table-wrap[4]#t0004", "version": null, "note": "Prognostic Biomarkers in Pheochromocytoma and Paraganglioma", "structure": {"pmcid": "PMC7654541", "section_index": 4, "section_title": "Identification of Differentially Expressed lncRNA, miRNA, and mRNA", "row_count": 4, "column_count": 2}, "table": {"label": "Table 4", "caption": "Prognostic Biomarkers in Pheochromocytoma and Paraganglioma", "rows": [["Types of RNA", "Gene Symbols"], ["lncRNA", "AP006333.2, AP001486.2, AL133163.3, AL035071.1, AC156455.1, AC008969.1"], ["mRNA", "VPS37B, TTC38, RCAN3, PTPRJ, ORAI2, NTNG1, NKX3-1, MED12, MCM10, KIAA1958, IREB2, EPHA2, ENOSF1, CCNO, ANKRD36, ACAA1"], ["miRNA", "hsa-miR-148b-3p, hsa-miR-137, hsa-let-7b-3p, hsa-miR-338-5p, hsa-miR-338-3p, hsa-miR-181c-5p, hsa-miR-296-5p, hsa-miR-130b-3p"]], "row_count": 4, "column_count": 2, "numeric_cells": 3, "header_rows": 1, "locator": "section[13]/table-wrap[4]#t0004"}}, {"id": "asset:table:pmid:33192072:5", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:6de623d144106fa42145bc09563c6ac64088c27e36709653a699b129a78e2fc5", "bytes": 2496, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[13]/table-wrap[1]#t0001", "version": null, "note": "Top 25 Downregulated and Top 25 Upregulated mRNA", "structure": {"pmcid": "PMC7654541", "section_index": 13, "section_title": "Identification of Differentially Expressed lncRNA, miRNA, and mRNA", "row_count": 27, "column_count": 8}, "table": {"label": "Table 1", "caption": "Top 25 Downregulated and Top 25 Upregulated mRNA", "rows": [["Top 25 Downregulated mRNA", "Top 25 Upregulated mRNA"], ["Symbol", "logFC", "p-Value", "FDR", "Symbol", "logFC", "p-Value", "FDR"], ["SLC37A2", "−4.7892", "4.39E-23", "4.68E-20", "SLC8A3", "6.647444", "3.75E-10", "1.11E-08"], ["BAMBI", "−4.52141", "2.73E-18", "8.15E-16", "DCX", "7.528979", "1.78E-08", "3.56E-07"], ["KIAA1024", "−4.52581", "1.65E-17", "3.86E-15", "MCHR1", "8.29453", "1.66E-05", "0.000144"], ["FDX1", "−4.71937", "1.18E-16", "2.00E-14", "SYT2", "6.630999", "4.17E-05", "0.000321"], ["GALM", "−4.45526", "3.68E-16", "5.50E-14", "SOX11", "10.68805", "5.00E-05", "0.000374"], ["SLC16A9", "−4.55815", "1.06E-14", "1.09E-12", "POPDC3", "6.767155", "5.80E-05", "0.000425"], ["FDXR", "−4.47427", "1.51E-14", "1.52E-12", "OPRK1", "8.275423", "5.98E-05", "0.000437"], ["RGN", "−4.45929", "1.69E-14", "1.65E-12", "LINC00890", "8.426037", "8.39E-05", "0.000579"], ["ACSF2", "−4.46773", "2.39E-13", "1.66E-11", "FRMPD3", "7.092507", "0.000124", "0.000811"], ["ABCC3", "−4.94181", "4.25E-13", "2.79E-11", "WNT10A", "8.291287", "0.000184", "0.001157"], ["RBM47", "−4.59347", "7.39E-13", "4.45E-11", "SIX3", "9.535783", "0.000206", "0.001268"], ["APOC1", "−4.89113", "5.00E-12", "2.33E-10", "VWA5B1", "7.094693", "0.000255", "0.001531"], ["SEMA3B", "−4.48062", "1.31E-11", "5.55E-10", "RASSF6", "8.27211", "0.000575", "0.003061"], ["AVPR1A", "−4.62031", "1.90E-11", "7.60E-10", "APCDD1L", "8.018701", "0.000806", "0.004064"], ["AOX1", "−5.13871", "2.26E-11", "8.86E-10", "NAT16", "6.691399", "0.000983", "0.004763"], ["DHCR24", "−4.70229", "4.93E-11", "1.77E-09", "THSD7B", "6.903341", "0.001365", "0.006258"], ["TPD52L1", "−4.68078", "6.29E-11", "2.20E-09", "TMEM132D", "7.417302", "0.001967", "0.008508"], ["ALDH1L1", "−4.53166", "5.87E-10", "1.67E-08", "SHOX2", "7.456944", "0.002452", "0.010212"], ["NOV", "−4.81279", "6.29E-10", "1.78E-08", "NPY", "7.471494", "0.003273", "0.012944"], ["SLC47A1", "−4.43845", "6.60E-09", "1.46E-07", "KCNJ6", "6.641958", "0.003813", "0.014677"], ["NGEF", "−4.64199", "9.61E-09", "2.04E-07", "OPRM1", "6.85908", "0.007868", "0.026291"], ["ADGRV1", "−4.61943", "2.23E-08", "4.35E-07", "PCDH11X", "7.112357", "0.009235", "0.029883"], ["STAR", "−5.34045", "2.86E-08", "5.42E-07", "GNG8", "7.149684", "0.009424", "0.03038"], ["SERPINA5", "−4.4036", "3.61E-07", "5.13E-06", "ADCYAP1", "7.827243", "0.011811", "0.036424"], ["CYP11A1", "−4.90555", "1.03E-06", "1.28E-05", "CNTNAP4", "6.819379", "0.016655", "0.047662"]], "row_count": 27, "column_count": 8, "numeric_cells": 166, "header_rows": 2, "locator": "section[13]/table-wrap[1]#t0001"}}, {"id": "asset:table:pmid:33192072:6", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:79e654e38782f4994d40000f9091956fe8e22a3b8398f5dfba29144a14b920a3", "bytes": 2682, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[13]/table-wrap[2]#t0002", "version": null, "note": "Top 25 Downregulated and Top 25 Upregulated lncRNA", "structure": {"pmcid": "PMC7654541", "section_index": 13, "section_title": "Identification of Differentially Expressed lncRNA, miRNA, and mRNA", "row_count": 27, "column_count": 8}, "table": {"label": "Table 2", "caption": "Top 25 Downregulated and Top 25 Upregulated lncRNA", "rows": [["Top 25 Downregulated lncRNA", "Top 25 Upregulated lncRNA"], ["Symbol", "logFC", "p-Value", "FDR", "Symbol", "logFC", "p-Value", "FDR"], ["AC073957.3", "−3.76797", "3.86E-17", "8.01E-15", "AC068700.1", "5.634188", "1.28E-11", "5.45E-10"], ["OIP5-AS1", "−1.56095", "5.60E-13", "3.50E-11", "AL022313.4", "5.727269", "1.34E-11", "5.64E-10"], ["ZNF503-AS2", "−3.251", "2.16E-11", "8.57E-10", "AL731557.1", "5.794468", "4.70E-10", "1.37E-08"], ["GSEC", "−2.11874", "2.36E-09", "5.80E-08", "AL390294.1", "6.21209", "5.81E-10", "1.66E-08"], ["DLGAP1-AS1", "−2.68487", "1.07E-08", "2.25E-07", "AL136964.1", "5.748429", "2.67E-09", "6.49E-08"], ["AC093157.1", "−1.71001", "6.11E-08", "1.06E-06", "AP002840.1", "6.246437", "6.31E-09", "1.40E-07"], ["AC026801.3", "−2.28817", "9.70E-08", "1.60E-06", "AL133163.3", "6.110686", "1.00E-08", "2.12E-07"], ["AL021453.1", "−2.33787", "1.08E-07", "1.75E-06", "AC105389.3", "6.985011", "2.29E-08", "4.46E-07"], ["AL354892.2", "−1.72175", "3.02E-07", "4.36E-06", "AC026369.1", "5.772437", "2.68E-08", "5.11E-07"], ["AC105942.1", "−1.90242", "7.62E-07", "9.82E-06", "MAPT-AS1", "7.141991", "1.39E-07", "2.20E-06"], ["AL445524.1", "−1.891", "1.44E-06", "1.72E-05", "AP006333.2", "7.895482", "1.75E-07", "2.68E-06"], ["LINC00174", "−1.54625", "5.17E-06", "5.27E-05", "LINC01930", "5.840071", "4.20E-07", "5.85E-06"], ["DANCR", "−1.64292", "5.70E-06", "5.73E-05", "LINC02287", "5.736795", "8.24E-07", "1.05E-05"], ["AC068888.1", "−1.69542", "1.11E-05", "0.000102", "AC010478.1", "5.881153", "1.23E-06", "1.50E-05"], ["NR2F1-AS1", "−2.24175", "1.84E-05", "0.000157", "AC005828.4", "6.087545", "4.65E-06", "4.79E-05"], ["MIR99AHG", "−2.2713", "2.05E-05", "0.000173", "LINC01982", "6.1136", "1.04E-05", "9.67E-05"], ["TMEM9B-AS1", "−1.60771", "5.64E-05", "0.000415", "UNC5B-AS1", "5.868469", "1.83E-05", "0.000156"], ["MIR22HG", "−1.56325", "0.000359", "0.002056", "KRTAP5-AS1", "5.581534", "2.19E-05", "0.000184"], ["ACVR2B-AS1", "−1.53248", "0.000457", "0.002526", "SATB1-AS1", "5.683773", "0.000118", "0.000785"], ["AC087741.1", "−1.88727", "0.000474", "0.002606", "GACAT2", "5.635535", "0.000123", "0.000808"], ["RNF144A-AS1", "−2.29893", "0.000715", "0.003684", "AC022893.2", "5.704634", "0.000135", "0.000878"], ["SH3BP5-AS1", "−1.66577", "0.000856", "0.004266", "AC079160.1", "6.192744", "0.000576", "0.003066"], ["CASC15", "−1.81374", "0.005303", "0.019168", "PP14571", "5.763316", "0.003315", "0.013082"], ["HOTAIRM1", "−1.59477", "0.007733", "0.025956", "AC010931.2", "6.202024", "0.005343", "0.019286"], ["AL365181.3", "−1.96367", "0.009386", "0.03028", "LINC00648", "5.741248", "0.008911", "0.029069"]], "row_count": 27, "column_count": 8, "numeric_cells": 188, "header_rows": 2, "locator": "section[13]/table-wrap[2]#t0002"}}, {"id": "asset:table:pmid:33192072:7", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": 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The physical bench the paper used is not, so a physical validation cannot be run here."}, "data": {"tier": "R1", "reachable": true, "accessions": ["GSE19422"], "resolved_accessions": ["GSE19422"], "statements": ["The authors declare that the data supporting the findings of this study are available within the article."], "basis": "The paper names GSE19422 in Gene Expression Omnibus (GEO) and the accession resolves in the repository. 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