pmid:33251083

Identification of potential mRNA panels for severe acute respiratory syndrome coronavirus 2 (COVID-19) diagnosis and treatment using microarray dataset and bioinformatics methods.

Basavaraj Vastrad · Chanabasayya Vastrad · Anandkumar Tengli

3 Biotech · 2020 doi:10.1007/s13205-020-02406-y

Abstract

The goal of the present investigation is to identify the differentially expressed genes (DEGs) between SARS-CoV-2 infected and normal control samples to investigate the molecular mechanisms of infection with SARS-CoV-2. The microarray data of the dataset E-MTAB-8871 were retrieved from the ArrayExpress database. Pathway and Gene Ontology (GO) enrichment study, protein-protein interaction (PPI) network, modules, target gene-miRNA regulatory network, and target gene-TF regulatory network have been performed. Subsequently, the key genes were validated using an analysis of the receiver operating characteristic (ROC) curve. In SARS-CoV-2 infection, a total of 324 DEGs (76 up- and 248 down-regulated genes) were identified and enriched in a number of associated SARS-CoV-2 infection pathways and GO terms. Hub and target genes such as TP53, HRAS, MAPK11, RELA, IKZF3, IFNAR2, SKI, TNFRSF13C, JAK1, TRAF6, KLRF2, CD1A were identified from PPI network, target gene-miRNA regulatory network, and target gene-TF regulatory network. Study of the ROC showed that ten genes (CCL5, IFNAR2, JAK2, MX1, STAT1, BID, CD55, CD80, HAL-B, and HLA-DMA) were substantially involved in SARS-CoV-2 patients. The present investigation identified key genes and pathways that deepen our understanding of the molecular mechanisms of SARS-CoV-2 infection, and could be used for SARS-CoV-2 infection as diagnostic and therapeutic biomarkers.

The publication

PubMed · PMID 33251083 The record in the National Library of Medicine.
The publisher's article · doi:10.1007/s13205-020-02406-y 3 Biotech · 2020
Basavaraj Vastrad · Chanabasayya Vastrad · Anandkumar Tengli

Source data and code

10.1007/s13205-020-02406-y manuscript · resolved
E-MTAB-8871 raw · resolved

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Handoff: revision 8 · sha256:67a403dcfd2847afeba72fb21abfc7c5844dde2af2b8a59a00407952574dc67e

Five-stage experiment

1 data generation Definition microarray · partial
2 normalise counts Definition differential_expression · supported

The order is the order the experiment runs them in. The full definitions, contracts and evidence are in the file below.

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Execution evidence has not yet been added to this .science file. Explore its methods, data and open questions to plan the next step.

In this file

The fields below come from the published .science file. Expand a section to inspect its evidence.

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Identification of potential mRNA panels for severe acute respiratory syndrome coronavirus 2 (COVID-19) diagnosis and treatment using microarray dataset and bioinformatics methods.

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10.1007/s13205-020-02406-y

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33251083

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Basavaraj Vastrad

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Chanabasayya Vastrad

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Anandkumar Tengli

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The limma package in R Software was used for background correction, quantile normalization and probe summarization, and limma package was also applied for DEGs identification (Ritchie et al. 2015).

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The limma package in R Software was used for background correction, quantile normalization and probe summarization, and limma package was also applied for DEGs identification (Ritchie et al. 2015).

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The datasets supporting the conclusions of this article are available in the ArrayExpress (https://www.ebi.ac.uk/arrayexpress) repository. [(E-MTAB-8871) (https://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-8871/)].

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Identification of DEGs

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Table 1

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The statistical metrics for key differentially expressed genes (DEGs)

rows array · 325 items

[0] array · 7 items

[0]

Gene Symbol

[1]

logFC

[2]

pValue

[3]

adj.P.Val

[4]

t value

[5]

Regulation

[6]

Gene Name

[1] array · 7 items

[0]

JAK1

[1]

0.641818

[2]

1.84E − 11

[3]

1.84E − 11

[4]

9.973193

[5]

[6]

Janus kinase 1

[2] array · 7 items

[0]

ZAP70

[1]

0.810545

[2]

2.91E − 10

[3]

2.91E − 10

[4]

8.897328

[5]

[6]

Zeta chain of T cell receptor associated protein kinase 70

[3] array · 7 items

[0]

CCR5

[1]

1.239182

[2]

3.04E − 10

[3]

3.04E − 10

[4]

8.880753

[5]

[6]

C–C motif chemokine receptor 5 (gene/pseudogene)

[4] array · 7 items

[0]

CTNNB1

[1]

0.633545

[2]

4.11E − 10

[3]

4.11E − 10

[4]

8.766907

[5]

[6]

Catenin beta 1

[5] array · 7 items

[0]

TRAF6

[1]

0.644773

[2]

7.11E − 10

[3]

7.11E − 10

[4]

8.561082

[5]

[6]

TNF receptor associated factor 6

[6] array · 7 items

[0]

FYN

[1]

0.536182

[2]

1.96E − 08

[3]

1.96E − 08

[4]

7.357891

[5]

[6]

FYN proto-oncogene, Src family tyrosine kinase

[7] array · 7 items

[0]

HRAS

[1]

0.668773

[2]

2.14E − 08

[3]

2.14E − 08

[4]

7.325507

[5]

[6]

HRas proto-oncogene, GTPase

[8] array · 7 items

[0]

ITGB2

[1]

0.805182

[2]

2.8E − 06

[3]

2.8E − 06

[4]

5.644273

[5]

[6]

Integrin subunit beta 2

[9] array · 7 items

[0]

ZBTB16

[1]

1.099955

[2]

3.88E − 06

[3]

3.88E − 06

[4]

5.53388

[5]

[6]

Zinc finger and BTB domain containing 16

[10] array · 7 items

[0]

ABL1

[1]

0.468091

[2]

4.46E − 06

[3]

4.46E − 06

[4]

5.486138

[5]

[6]

ABL proto-oncogene 1, non-receptor tyrosine kinase

[11] array · 7 items

[0]

CX3CR1

[1]

0.834227

[2]

6.3E − 06

[3]

6.3E − 06

[4]

5.369313

[5]

[6]

C-X3-C motif chemokine receptor 1

[12] array · 7 items

[0]

PDCD1

[1]

0.880955

[2]

7.79E − 06

[3]

7.79E − 06

[4]

5.297093

[5]

[6]

Programmed cell death 1

[13] array · 7 items

[0]

IRF5

[1]

0.884364

[2]

1.56E − 05

[3]

1.56E − 05

[4]

5.062275

[5]

[6]

Interferon regulatory factor 5

[14] array · 7 items

[0]

IL2RG

[1]

0.590818

[2]

1.7E − 05

[3]

1.7E − 05

[4]

5.032467

[5]

[6]

Interleukin 2 receptor subunit gamma

[15] array · 7 items

[0]

IKZF3

[1]

0.467273

[2]

1.78E − 0E − 05

[3]

1.78E − 05

[4]

5.016592

[5]

[6]

IKAROS family zinc finger 3

[16] array · 7 items

[0]

CCR1

[1]

1.613727

[2]

2.3E − 05

[3]

2.3E − 05

[4]

4.929543

[5]

[6]

C–C motif chemokine receptor 1

[17] array · 7 items

[0]

CD99

[1]

0.398773

[2]

4.76E − 05

[3]

4.76E − 05

[4]

4.681138

[5]

[6]

CD99 molecule (Xg blood group)

[18] array · 7 items

[0]

SMAD5

[1]

0.349818

[2]

5.02E − 05

[3]

5.02E − 05

[4]

4.662446

[5]

[6]

SMAD family member 5

[19] array · 7 items

[0]

CD247

[1]

0.51

[2]

5.34E − 05

[3]

5.34E − 05

[4]

4.641555

[5]

[6]

CD247 molecule

[20] array · 7 items

[0]

TP53

[1]

0.372273

[2]

5.85E − 05

[3]

5.85E − 05

[4]

4.609909

[5]

[6]

Tumor protein p53

[21] array · 7 items

[0]

LAG3

[1]

0.988591

[2]

6.64E − 05

[3]

6.64E − 05

[4]

4.566916

[5]

[6]

Lymphocyte activating 3

[22] array · 7 items

[0]

LCP2

[1]

0.432682

[2]

6.74E − 05

[3]

6.74E − 05

[4]

4.561553

[5]

[6]

Lymphocyte cytosolic protein 2

[23] array · 7 items

[0]

SLAMF7

[1]

0.577409

[2]

8.58E − 05

[3]

8.58E − 05

[4]

4.478485

[5]

[6]

SLAM family member 7

[24] array · 7 items

[0]

TMEM173

[1]

0.377318

[2]

0.000103

[3]

0.000103

[4]

4.416144

[5]

[6]

Transmembrane protein 173

[25] array · 7 items

[0]

CUL9

[1]

0.4155

[2]

0.000119

[3]

0.000119

[4]

4.366647

[5]

[6]

Cullin 9

[26] array · 7 items

[0]

[1]

1.280182

[2]

0.000153

[3]

0.000153

[4]

4.279415

[5]

[6]

Complement C2

[27] array · 7 items

[0]

GNLY

[1]

1.067364

[2]

0.000167

[3]

0.000167

[4]

4.248083

[5]

[6]

Granulysin

[28] array · 7 items

[0]

ATG10

[1]

0.490955

[2]

0.000234

[3]

0.000234

[4]

4.130655

[5]

[6]

Autophagy related 10

[29] array · 7 items

[0]

IKZF1

[1]

0.321682

[2]

0.000285

[3]

0.000285

[4]

4.061503

[5]

[6]

IKAROS family zinc finger 1

[30] array · 7 items

[0]

KIR_Activating_Subgroup_2

[1]

1.279318

[2]

0.00043

[3]

0.00043

[4]

3.915229

[5]

[6]

Killer-cell immunoglobulin-like receptorSubgroup 2

[31] array · 7 items

[0]

ITGAL

[1]

0.370273

[2]

0.000461

[3]

0.000461

[4]

3.890576

[5]

[6]

Integrin subunit alpha L

[32] array · 7 items

[0]

SERPING1

[1]

1.992773

[2]

0.00057

[3]

0.00057

[4]

3.815201

[5]

[6]

Serpin family G member 1

[33] array · 7 items

[0]

STAT1

[1]

1.066864

[2]

0.000762

[3]

0.000762

[4]

3.711251

[5]

[6]

signal transducer and activator of transcription 1

[34] array · 7 items

[0]

CCRL2

[1]

0.621773

[2]

0.000844

[3]

0.000844

[4]

3.674266

[5]

[6]

C–C motif chemokine receptor like 2

[35] array · 7 items

[0]

RUNX1

[1]

0.392409

[2]

0.001035

[3]

0.001035

[4]

3.600334

[5]

[6]

RUNX family transcription factor 1

[36] array · 7 items

[0]

KIR_Activating_Subgroup_1

[1]

1.243455

[2]

0.001444

[3]

0.001444

[4]

3.478418

[5]

[6]

Killer-cell immunoglobulin-like receptor Subgroup 1

[37] array · 7 items

[0]

IFIH1

[1]

1.189

[2]

0.001492

[3]

0.001492

[4]

3.466339

[5]

[6]

Interferon induced with helicase C domain 1

[38] array · 7 items

[0]

GP1BB

[1]

1.252364

[2]

0.001517

[3]

0.001517

[4]

3.460324

[5]

[6]

Glycoprotein Ib platelet subunit beta

[39] array · 7 items

[0]

TBX21

[1]

0.557591

[2]

0.001716

[3]

0.001716

[4]

3.414736

[5]

[6]

T-box transcription factor 21

[40] array · 7 items

[0]

BST2

[1]

0.825727

[2]

0.00183

[3]

0.00183

[4]

3.390875

[5]

[6]

Bone marrow stromal cell antigen 2

[41] array · 7 items

[0]

JAK2

[1]

0.436727

[2]

0.001927

[3]

0.001927

[4]

3.371677

[5]

[6]

Janus kinase 2

[42] array · 7 items

[0]

PSMB9

[1]

0.490864

[2]

0.001928

[3]

0.001928

[4]

3.371431

[5]

[6]

Proteasome 20S subunit beta 9

[43] array · 7 items

[0]

XBP1

[1]

0.485455

[2]

0.002051

[3]

0.002051

[4]

3.348399

[5]

[6]

X-box binding protein 1

[44] array · 7 items

[0]

GBP1

[1]

0.999545

[2]

0.003627

[3]

0.003627

[4]

3.133218

[5]

[6]

Guanylate binding protein 1

[45] array · 7 items

[0]

STAT4

[1]

0.295591

[2]

0.003667

[3]

0.003667

[4]

3.129061

[5]

[6]

Signal transducer and activator of transcription 4

[46] array · 7 items

[0]

MAP4K1

[1]

0.2385

[2]

0.003959

[3]

0.003959

[4]

3.099644

[5]

[6]

Mitogen-activated protein kinase kinasekinasekinase 1

[47] array · 7 items

[0]

CCND3

[1]

0.326591

[2]

0.004076

[3]

0.004076

[4]

3.08846

[5]

[6]

cyclin D3

[48] array · 7 items

[0]

LILRA6

[1]

0.817091

[2]

0.004839

[3]

0.004839

[4]

3.022071

[5]

[6]

Leukocyte immunoglobulin like receptor A6

[49] array · 7 items

[0]

GFI1

[1]

0.495591

[2]

0.005741

[3]

0.005741

[4]

2.955427

[5]

[6]

Growth factor independent 1 transcriptional repressor

[50] array · 7 items

[0]

HLA-A

[1]

0.385909

[2]

0.005824

[3]

0.005824

[4]

2.949825

[5]

[6]

Major histocompatibility complex, class I, A

[51] array · 7 items

[0]

IL18RAP

[1]

0.982227

[2]

0.006135

[3]

0.006135

[4]

2.929331

[5]

[6]

Interleukin 18 receptor accessory protein

[52] array · 7 items

[0]

C1QBP

[1]

0.264182

[2]

0.006145

[3]

0.006145

[4]

2.928686

[5]

[6]

Complement C1q binding protein

[53] array · 7 items

[0]

CCL5

[1]

0.3105

[2]

0.006563

[3]

0.006563

[4]

2.902767

[5]

[6]

C–C motif chemokine ligand 5

[54] array · 7 items

[0]

SOCS1

[1]

0.704318

[2]

0.007115

[3]

0.007115

[4]

2.870801

[5]

[6]

Suppressor of cytokine signaling 1

[55] array · 7 items

[0]

STAT3

[1]

0.370545

[2]

0.010179

[3]

0.010179

[4]

2.72698

[5]

[6]

Signal transducer and activator of transcription 3

[56] array · 7 items

[0]

CEACAM1

[1]

0.784909

[2]

0.011682

[3]

0.011682

[4]

2.670737

[5]

[6]

CEA cell adhesion molecule 1

[57] array · 7 items

[0]

TLR2

[1]

0.589773

[2]

0.013287

[3]

0.013287

[4]

2.617647

[5]

[6]

toll like receptor 2

[58] array · 7 items

[0]

KLRK1

[1]

0.358136

[2]

0.014239

[3]

0.014239

[4]

2.588898

[5]

[6]

killer cell lectin like receptor K1

[59] array · 7 items

[0]

MAP4K2

[1]

0.221227

[2]

0.018828

[3]

0.018828

[4]

2.471244

[5]

[6]

Mitogen-activated protein kinase kinasekinasekinase 2

[60] array · 7 items

[0]

KLRC1

[1]

0.7945

[2]

0.019896

[3]

0.019896

[4]

2.4477

[5]

[6]

Killer cell lectin like receptor C1

[61] array · 7 items

[0]

ATG5

[1]

0.327

[2]

0.020137

[3]

0.020137

[4]

2.44253

[5]

[6]

Autophagy related 5

[62] array · 7 items

[0]

IL18R1

[1]

0.713136

[2]

0.020905

[3]

0.020905

[4]

2.426467

[5]

[6]

Interleukin 18 receptor 1

[63] array · 7 items

[0]

IKBKB

[1]

0.1695

[2]

0.027641

[3]

0.027641

[4]

2.304841

[5]

[6]

Inhibitor of nuclear factor kappa B kinase subunit beta

[64] array · 7 items

[0]

STAT5B

[1]

0.2575

[2]

0.032278

[3]

0.032278

[4]

2.235871

[5]

[6]

Signal transducer and activator of transcription 5B

[65] array · 7 items

[0]

MX1

[1]

1.111727

[2]

0.032817

[3]

0.032817

[4]

2.228441

[5]

[6]

MX dynamin like GTPase 1

[66] array · 7 items

[0]

IRF7

[1]

0.898909

[2]

0.033248

[3]

0.033248

[4]

2.222589

[5]

[6]

Interferon regulatory factor 7

[67] array · 7 items

[0]

TRAF2

[1]

0.171955

[2]

0.034273

[3]

0.034273

[4]

2.208908

[5]

[6]

TNF receptor associated factor 2

[68] array · 7 items

[0]

IFI35

[1]

0.725909

[2]

0.035093

[3]

0.035093

[4]

2.198229

[5]

[6]

Interferon induced protein 35

[69] array · 7 items

[0]

IKBKE

[1]

0.236545

[2]

0.035149

[3]

0.035149

[4]

2.197514

[5]

[6]

Inhibitor of nuclear factor kappa B kinase subunit epsilon

[70] array · 7 items

[0]

CLEC7A

[1]

0.421227

[2]

0.037828

[3]

0.037828

[4]

2.164155

[5]

[6]

C-type lectin domain containing 7A

[71] array · 7 items

[0]

LTB4R

[1]

0.465227

[2]

0.03902

[3]

0.03902

[4]

2.149988

[5]

[6]

Leukotriene B4 receptor

[72] array · 7 items

[0]

GZMB

[1]

0.437364

[2]

0.040654

[3]

0.040654

[4]

2.131179

[5]

[6]

Granzyme B

[73] array · 7 items

[0]

NLRP3

[1]

0.290364

[2]

0.04286

[3]

0.04286

[4]

2.106829

[5]

[6]

NLR family pyrin domain containing 3

[74] array · 7 items

[0]

LILRB2

[1]

0.299364

[2]

0.042931

[3]

0.042931

[4]

2.106059

[5]

[6]

Leukocyte immunoglobulin like receptor B2

[75] array · 7 items

[0]

IFNAR2

[1]

0.184136

[2]

0.048633

[3]

0.048633

[4]

2.047965

[5]

[6]

Interferon alpha and beta receptor subunit 2

[76] array · 7 items

[0]

KLRD1

[1]

0.4455

[2]

0.049759

[3]

0.049759

[4]

2.037205

[5]

[6]

Killer cell lectin like receptor D1

[77] array · 7 items

[0]

CD19

[1]

− 1.7175

[2]

5.18E − 16

[3]

5.18E − 16

[4]

− 14.7177

[5]

Down

[6]

CD19 molecule

[78] array · 7 items

[0]

CD22

[1]

− 1.757

[2]

4.93E − 15

[3]

4.93E − 15

[4]

− 13.592

[5]

Down

[6]

CD22 molecule

[79] array · 7 items

[0]

MS4A1

[1]

− 1.67741

[2]

1.67E − 14

[3]

1.67E − 14

[4]

− 13.0082

[5]

Down

[6]

Membrane spanning 4-domains A1

[80] array · 7 items

[0]

CD45RB

[1]

− 0.94709

[2]

4.17E − 14

[3]

4.17E − 14

[4]

− 12.5832

[5]

Down

[6]

Receptor-Type Tyrosine-Protein Phosphatase C

[81] array · 7 items

[0]

IL6R

[1]

− 2.0375

[2]

1.05E − 13

[3]

1.05E − 13

[4]

− 12.164

[5]

Down

[6]

interleukin 6 receptor

[82] array · 7 items

[0]

TNFRSF13C

[1]

− 1.46186

[2]

2.18E − 13

[3]

2.18E − 13

[4]

− 11.8375

[5]

Down

[6]

TNF receptor superfamily member 13C

[83] array · 7 items

[0]

PAX5

[1]

− 1.37636

[2]

2.92E − 13

[3]

2.92E − 13

[4]

− 11.7085

[5]

Down

[6]

Paired box 5

[84] array · 7 items

[0]

CD79A

[1]

− 1.29577

[2]

2.53E − 12

[3]

2.53E − 12

[4]

− 10.7841

[5]

Down

[6]

CD79a molecule

[85] array · 7 items

[0]

ARHGDIB

[1]

− 0.65064

[2]

3.68E − 12

[3]

3.68E − 12

[4]

− 10.6278

[5]

Down

[6]

Rho GDP dissociation inhibitor beta

[86] array · 7 items

[0]

HLA-DQB1

[1]

− 4.88305

[2]

5.18E − 12

[3]

5.18E − 12

[4]

− 10.4865

[5]

Down

[6]

Major histocompatibility complex, class II, DQ beta 1

[87] array · 7 items

[0]

HLA-DQA1

[1]

− 6.1155

[2]

1.8E − 11

[3]

1.8E − 11

[4]

− 9.98021

[5]

Down

[6]

Major histocompatibility complex, class II, DQ alpha 1

[88] array · 7 items

[0]

MAPKAPK2

[1]

− 0.99755

[2]

5.49E − 11

[3]

5.49E − 11

[4]

− 9.53915

[5]

Down

[6]

MAPK activated protein kinase 2

[89] array · 7 items

[0]

SLAMF6

[1]

− 0.87414

[2]

2.16E − 10

[3]

2.16E − 10

[4]

− 9.01008

[5]

Down

[6]

SLAM family member 6

[90] array · 7 items

[0]

PTGER4

[1]

− 0.76932

[2]

2.43E − 10

[3]

2.43E − 10

[4]

− 8.96519

[5]

Down

[6]

Prostaglandin E receptor 4

[91] array · 7 items

[0]

CD79B

[1]

− 0.84082

[2]

2.75E − 10

[3]

2.75E − 10

[4]

− 8.91788

[5]

Down

[6]

CD79b molecule

[92] array · 7 items

[0]

CD97

[1]

− 1.1985

[2]

3.22E − 10

[3]

3.22E − 10

[4]

− 8.85915

[5]

Down

[6]

Leukocyte antigen CD97

[93] array · 7 items

[0]

IL1RL2

[1]

− 1.04873

[2]

3.57E − 10

[3]

3.57E − 10

[4]

− 8.81964

[5]

Down

[6]

Interleukin 1 receptor like 2

[94] array · 7 items

[0]

CD1A

[1]

− 1.07114

[2]

3.6E − 10

[3]

3.6E − 10

[4]

− 8.81626

[5]

Down

[6]

CD1a molecule

[95] array · 7 items

[0]

IL1RAP

[1]

− 1.43418

[2]

8.92E − 10

[3]

8.92E − 10

[4]

− 8.47672

[5]

Down

[6]

Interleukin 1 receptor accessory protein

[96] array · 7 items

[0]

TNFSF12

[1]

− 0.53718

[2]

2.42E − 09

[3]

2.42E − 09

[4]

− 8.10915

[5]

Down

[6]

TNF superfamily member 12

[97] array · 7 items

[0]

AICDA

[1]

− 0.94759

[2]

2.89E − 09

[3]

2.89E − 09

[4]

− 8.04473

[5]

Down

[6]

Activation induced cytidinedeaminase

[98] array · 7 items

[0]

MBP

[1]

− 0.77614

[2]

4.02E − 09

[3]

4.02E − 09

[4]

− 7.92468

[5]

Down

[6]

myelin basic protein

[99] array · 7 items

[0]

TRAF4

[1]

− 0.67777

[2]

5.69E − 09

[3]

5.69E − 09

[4]

− 7.79888

[5]

Down

[6]

TNF receptor associated factor 4

[100] array · 7 items

[0]

MIF

[1]

− 0.59309

[2]

5.94E − 09

[3]

5.94E − 09

[4]

− 7.78344

[5]

Down

[6]

Macrophage migration inhibitory factor

[101] array · 7 items

[0]

CCBP2

[1]

− 1.34027

[2]

6.31E − 09

[3]

6.31E − 09

[4]

− 7.76207

[5]

Down

[6]

Chemokine-binding protein 2

[102] array · 7 items

[0]

CCL22

[1]

− 0.68986

[2]

8.3E − 09

[3]

8.3E − 09

[4]

− 7.66358

[5]

Down

[6]

C–C motif chemokine ligand 22

[103] array · 7 items

[0]

HLA-DRA

[1]

− 1.87223

[2]

9.28E − 09

[3]

9.28E − 09

[4]

− 7.62328

[5]

Down

[6]

Major histocompatibility complex, class II, DR alpha

[104] array · 7 items

[0]

FCER1A

[1]

− 2.15768

[2]

9.79E − 09

[3]

9.79E − 09

[4]

− 7.60411

[5]

Down

[6]

Fc fragment of IgE receptor Ia

[105] array · 7 items

[0]

LILRB5

[1]

− 0.76595

[2]

1.11E − 08

[3]

1.11E − 08

[4]

− 7.55809

[5]

Down

[6]

Leukocyte immunoglobulin like receptor B5

[106] array · 7 items

[0]

CCL15

[1]

− 0.7105

[2]

1.48E − 08

[3]

1.48E − 08

[4]

− 7.4567

[5]

Down

[6]

C–C motif chemokine ligand 15

[107] array · 7 items

[0]

IL12B

[1]

− 0.99886

[2]

1.5E − 08

[3]

1.5E − 08

[4]

− 7.45174

[5]

Down

[6]

Interleukin 12B

[108] array · 7 items

[0]

TFRC

[1]

− 1.07782

[2]

1.61E − 08

[3]

1.61E − 08

[4]

− 7.42698

[5]

Down

[6]

Transferrin receptor

[109] array · 7 items

[0]

EBI3

[1]

− 0.72195

[2]

1.86E − 08

[3]

1.86E − 08

[4]

− 7.37653

[5]

Down

[6]

Epstein-Barr virus induced 3

[110] array · 7 items

[0]

IL4

[1]

− 0.69941

[2]

2.72E − 08

[3]

2.72E − 08

[4]

− 7.24189

[5]

Down

[6]

Interleukin 4

[111] array · 7 items

[0]

ICAM2

[1]

− 0.74745

[2]

2.86E − 08

[3]

2.86E − 08

[4]

− 7.22422

[5]

Down

[6]

Intercellular adhesion molecule 2

[112] array · 7 items

[0]

KLRAP1

[1]

− 1.0865

[2]

3.09E − 08

[3]

3.09E − 08

[4]

− 7.19683

[5]

Down

[6]

Killer cell lectin-like receptor subfamily A pseudogene 1

[113] array · 7 items

[0]

CD40

[1]

− 0.79436

[2]

3.29E − 08

[3]

3.29E − 08

[4]

− 7.17439

[5]

Down

[6]

CD40 molecule

[114] array · 7 items

[0]

IL22RA2

[1]

− 0.6365

[2]

4.34E − 08

[3]

4.34E − 08

[4]

− 7.07766

[5]

Down

[6]

Interleukin 22 receptor subunit alpha 2

[115] array · 7 items

[0]

IL2

[1]

− 0.64395

[2]

4.65E − 08

[3]

4.65E − 08

[4]

− 7.05298

[5]

Down

[6]

Interleukin 2

[116] array · 7 items

[0]

IL29

[1]

− 0.64395

[2]

4.65E − 08

[3]

4.65E − 08

[4]

− 7.05298

[5]

Down

[6]

Interleukin 29

[117] array · 7 items

[0]

CD3E

[1]

− 0.73018

[2]

5.24E − 08

[3]

5.24E − 08

[4]

− 7.01159

[5]

Down

[6]

CD3e molecule

[118] array · 7 items

[0]

CD55

[1]

− 0.92114

[2]

5.29E − 08

[3]

5.29E − 08

[4]

− 7.00828

[5]

Down

[6]

CD55 molecule (Cromer blood group)

[119] array · 7 items

[0]

IL19

[1]

− 0.6555

[2]

5.33E − 08

[3]

5.33E − 08

[4]

− 7.00515

[5]

Down

[6]

Interleukin 19

[120] array · 7 items

[0]

NOS2

[1]

− 0.81432

[2]

5.6E − 08

[3]

5.6E − 08

[4]

− 6.98829

[5]

Down

[6]

Nitric oxide synthase 2

[121] array · 7 items

[0]

C4BPA

[1]

− 1.83359

[2]

5.78E − 08

[3]

5.78E − 08

[4]

− 6.97697

[5]

Down

[6]

Complement component 4 binding protein alpha

[122] array · 7 items

[0]

CCL26

[1]

− 0.57677

[2]

6.5E − 08

[3]

6.5E − 08

[4]

− 6.93596

[5]

Down

[6]

C–C motif chemokine ligand 26

[123] array · 7 items

[0]

CDH5

[1]

− 0.60586

[2]

7.09E − 08

[3]

7.09E − 08

[4]

− 6.90577

[5]

Down

[6]

Cadherin 5

[124] array · 7 items

[0]

IL9

[1]

− 0.60586

[2]

7.09E − 08

[3]

7.09E − 08

[4]

− 6.90577

[5]

Down

[6]

Interleukin 9

[125] array · 7 items

[0]

FCGRT

[1]

− 0.75709

[2]

8.18E − 08

[3]

8.18E − 08

[4]

− 6.85603

[5]

Down

[6]

Fc fragment of IgG receptor and transporter

[126] array · 7 items

[0]

C8B

[1]

− 0.6555

[2]

1.1E − 07

[3]

1.1E − 07

[4]

− 6.75159

[5]

Down

[6]

Complement C8 beta chain

[127] array · 7 items

[0]

IL5

[1]

− 0.64086

[2]

1.16E − 07

[3]

1.16E − 07

[4]

− 6.7344

[5]

Down

[6]

Interleukin 5

[128] array · 7 items

[0]

PIGR

[1]

− 0.66695

[2]

1.33E − 07

[3]

1.33E − 07

[4]

− 6.68821

[5]

Down

[6]

Polymeric immunoglobulin receptor

[129] array · 7 items

[0]

XCL1

[1]

− 1.06423

[2]

1.98E − 07

[3]

1.98E − 07

[4]

− 6.54928

[5]

Down

[6]

X-C motif chemokine ligand 1

[130] array · 7 items

[0]

AIRE

[1]

− 0.78032

[2]

2.01E − 07

[3]

2.01E − 07

[4]

− 6.5441

[5]

Down

[6]

Autoimmune regulator

[131] array · 7 items

[0]

IL3

[1]

− 0.60723

[2]

2.08E − 07

[3]

2.08E − 07

[4]

− 6.53283

[5]

Down

[6]

Interleukin 3

[132] array · 7 items

[0]

CCL16

[1]

− 0.6195

[2]

2.31E − 07

[3]

2.31E − 07

[4]

− 6.4973

[5]

Down

[6]

C–C motif chemokine ligand 16

[133] array · 7 items

[0]

CCL7

[1]

− 0.6195

[2]

2.31E − 07

[3]

2.31E − 07

[4]

− 6.4973

[5]

Down

[6]

C–C motif chemokine ligand 7

[134] array · 7 items

[0]

CSF2

[1]

− 0.6195

[2]

2.31E − 07

[3]

2.31E − 07

[4]

− 6.4973

[5]

Down

[6]

Colony stimulating factor 2

[135] array · 7 items

[0]

ITLN2

[1]

− 0.6195

[2]

2.31E − 07

[3]

2.31E − 07

[4]

− 6.4973

[5]

Down

[6]

Intelectin 2

[136] array · 7 items

[0]

THY1

[1]

− 0.6195

[2]

2.31E − 07

[3]

2.31E − 07

[4]

− 6.4973

[5]

Down

[6]

Thy-1 cell surface antigen

[137] array · 7 items

[0]

IL21

[1]

− 0.70245

[2]

3.28E − 07

[3]

3.28E − 07

[4]

− 6.37574

[5]

Down

[6]

Interleukin 21

[138] array · 7 items

[0]

BCL2

[1]

− 0.7385

[2]

4.11E − 07

[3]

4.11E − 07

[4]

− 6.29854

[5]

Down

[6]

BCL2 apoptosis regulator

[139] array · 7 items

[0]

EDNRB

[1]

− 0.60541

[2]

4.11E − 07

[3]

4.11E − 07

[4]

− 6.29833

[5]

Down

[6]

Endothelin receptor type B

[140] array · 7 items

[0]

CCR6

[1]

− 0.88205

[2]

4.78E − 07

[3]

4.78E − 07

[4]

− 6.24666

[5]

Down

[6]

C–C motif chemokine receptor 6

[141] array · 7 items

[0]

TIRAP

[1]

− 0.70182

[2]

5.91E − 07

[3]

5.91E − 07

[4]

− 6.17398

[5]

Down

[6]

TIR domain containing adaptor protein

[142] array · 7 items

[0]

STAT6

[1]

− 0.52186

[2]

6.37E − 07

[3]

6.37E − 07

[4]

− 6.14848

[5]

Down

[6]

Signal transducer and activator of transcription 6

[143] array · 7 items

[0]

PSMB10

[1]

− 0.43945

[2]

6.43E − 07

[3]

6.43E − 07

[4]

− 6.14519

[5]

Down

[6]

Proteasome 20S subunit beta 10

[144] array · 7 items

[0]

SKI

[1]

− 0.52182

[2]

7.16E − 07

[3]

7.16E − 07

[4]

− 6.10886

[5]

Down

[6]

SKI proto-oncogene

[145] array · 7 items

[0]

RAG2

[1]

− 0.56723

[2]

8.47E − 07

[3]

8.47E − 07

[4]

− 6.05149

[5]

Down

[6]

Recombination activating 2

[146] array · 7 items

[0]

CD209

[1]

− 0.7285

[2]

8.56E − 07

[3]

8.56E − 07

[4]

− 6.04758

[5]

Down

[6]

CD209 molecule

[147] array · 7 items

[0]

VTN

[1]

− 0.68305

[2]

9.43E − 07

[3]

9.43E − 07

[4]

− 6.01488

[5]

Down

[6]

Vitronectin

[148] array · 7 items

[0]

IFNB1

[1]

− 0.57768

[2]

9.97E − 07

[3]

9.97E − 07

[4]

− 5.99573

[5]

Down

[6]

Interferon beta 1

[149] array · 7 items

[0]

EOMES

[1]

− 0.77505

[2]

1.47E − 06

[3]

1.47E − 06

[4]

− 5.8643

[5]

Down

[6]

Eomesodermin

[150] array · 7 items

[0]

CD74

[1]

− 0.69905

[2]

1.52E − 06

[3]

1.52E − 06

[4]

− 5.85145

[5]

Down

[6]

CD74 molecule

[151] array · 7 items

[0]

CCR10

[1]

− 0.60368

[2]

1.7E − 06

[3]

1.7E − 06

[4]

− 5.81503

[5]

Down

[6]

C–C motif chemokine receptor 10

[152] array · 7 items

[0]

LGALS3

[1]

− 1.12309

[2]

1.85E − 06

[3]

1.85E − 06

[4]

− 5.78563

[5]

Down

[6]

Galectin 3

[153] array · 7 items

[0]

PDGFB

[1]

− 0.64241

[2]

1.86E − 06

[3]

1.86E − 06

[4]

− 5.78395

[5]

Down

[6]

Platelet derived growth factor subunit B

[154] array · 7 items

[0]

ICAM4

[1]

− 0.96814

[2]

1.96E − 06

[3]

1.96E − 06

[4]

− 5.76557

[5]

Down

[6]

Intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)

[155] array · 7 items

[0]

ICOSLG

[1]

− 0.74791

[2]

2.07E − 06

[3]

2.07E − 06

[4]

− 5.74698

[5]

Down

[6]

Inducible T cell costimulator ligand

[156] array · 7 items

[0]

[1]

− 0.52132

[2]

2.66E − 06

[3]

2.66E − 06

[4]

− 5.66169

[5]

Down

[6]

Complement C9

[157] array · 7 items

[0]

IL16

[1]

− 0.45973

[2]

2.88E − 06

[3]

2.88E − 06

[4]

− 5.63467

[5]

Down

[6]

Interleukin 16

[158] array · 7 items

[0]

RELA

[1]

− 0.47205

[2]

3.09E − 06

[3]

3.09E − 06

[4]

− 5.61097

[5]

Down

[6]

RELA proto-oncogene, NF-kB subunit

[159] array · 7 items

[0]

DEFB1

[1]

− 0.8105

[2]

3.38E − 06

[3]

3.38E − 06

[4]

− 5.58051

[5]

Down

[6]

Defensin beta 1

[160] array · 7 items

[0]

IL13RA1

[1]

− 0.90159

[2]

3.41E − 06

[3]

3.41E − 06

[4]

− 5.57755

[5]

Down

[6]

Interleukin 13 receptor subunit alpha 1

[161] array · 7 items

[0]

HLA-DOB

[1]

− 1.24595

[2]

3.65E − 06

[3]

3.65E − 06

[4]

− 5.55493

[5]

Down

[6]

Major histocompatibility complex, class II, DO beta

[162] array · 7 items

[0]

KIR3DL3

[1]

− 0.56905

[2]

3.78E − 06

[3]

3.78E − 06

[4]

− 5.54244

[5]

Down

[6]

Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3

[163] array · 7 items

[0]

HLA-C

[1]

− 0.93941

[2]

3.97E − 06

[3]

3.97E − 06

[4]

− 5.52568

[5]

Down

[6]

Major histocompatibility complex, class I, C

[164] array · 7 items

[0]

KLRB1

[1]

− 1.79632

[2]

5.31E − 06

[3]

5.31E − 06

[4]

− 5.42732

[5]

Down

[6]

Killer cell lectin like receptor B1

[165] array · 7 items

[0]

HLA-DMB

[1]

− 0.85005

[2]

5.86E − 06

[3]

5.86E − 06

[4]

− 5.39367

[5]

Down

[6]

Major histocompatibility complex, class II, DM beta

[166] array · 7 items

[0]

KLRF2

[1]

− 0.53859

[2]

6E − 06

[3]

6E − 06

[4]

− 5.3857

[5]

Down

[6]

Killer cell lectin like receptor F2

[167] array · 7 items

[0]

ICAM3

[1]

− 0.66718

[2]

6.38E − 06

[3]

6.38E − 06

[4]

− 5.36481

[5]

Down

[6]

Intercellular adhesion molecule 3

[168] array · 7 items

[0]

IL28A

[1]

− 0.55718

[2]

7.03E − 06

[3]

7.03E − 06

[4]

− 5.33194

[5]

Down

[6]

Interleukin 28A

[169] array · 7 items

[0]

SIGIRR

[1]

− 0.41545

[2]

7.52E − 06

[3]

7.52E − 06

[4]

− 5.30925

[5]

Down

[6]

Single Ig and TIR domain containing

[170] array · 7 items

[0]

MASP2

[1]

− 0.68927

[2]

7.93E − 06

[3]

7.93E − 06

[4]

− 5.29109

[5]

Down

[6]

Mannan binding lectin serine peptidase 2

[171] array · 7 items

[0]

CSF2RB

[1]

− 1.12332

[2]

8.36E − 06

[3]

8.36E − 06

[4]

− 5.27318

[5]

Down

[6]

Colony stimulating factor 2 receptor beta common subunit

[172] array · 7 items

[0]

CD46

[1]

− 0.59905

[2]

9.11E − 06

[3]

9.11E − 06

[4]

− 5.24408

[5]

Down

[6]

CD46 molecule

[173] array · 7 items

[0]

S1PR1

[1]

− 0.60436

[2]

9.23E − 06

[3]

9.23E − 06

[4]

− 5.23966

[5]

Down

[6]

Sphingosine − 1-phosphate receptor 1

[174] array · 7 items

[0]

TLR9

[1]

− 0.56841

[2]

1.05E − 05

[3]

1.05E − 05

[4]

− 5.19438

[5]

Down

[6]

Toll like receptor 9

[175] array · 7 items

[0]

HLA-DPB1

[1]

− 0.70064

[2]

1.07E − 05

[3]

1.07E − 05

[4]

− 5.19046

[5]

Down

[6]

Major histocompatibility complex, class II, DP beta 1

[176] array · 7 items

[0]

CCL13

[1]

− 0.57018

[2]

1.16E − 05

[3]

1.16E − 05

[4]

− 5.16161

[5]

Down

[6]

C–C motif chemokine ligand 13

[177] array · 7 items

[0]

PLA2G2E

[1]

− 0.67155

[2]

1.19E − 05

[3]

1.19E − 05

[4]

-5.15362

[5]

Down

[6]

Phospholipase A2 group IIE

[178] array · 7 items

[0]

IL20

[1]

− 0.67032

[2]

1.29E − 05

[3]

1.29E − 05

[4]

-5.12687

[5]

Down

[6]

Interleukin 20

[179] array · 7 items

[0]

PTAFR

[1]

− 0.91373

[2]

1.37E − 05

[3]

1.37E − 05

[4]

-5.10671

[5]

Down

[6]

Platelet activating factor receptor

[180] array · 7 items

[0]

TGFBI

[1]

− 0.59209

[2]

1.44E − 05

[3]

1.44E − 05

[4]

-5.08943

[5]

Down

[6]

Transforming growth factor beta induced

[181] array · 7 items

[0]

IL26

[1]

− 0.50514

[2]

1.52E − 05

[3]

1.52E − 05

[4]

-5.07029

[5]

Down

[6]

Interleukin 26

[182] array · 7 items

[0]

IFNAR1

[1]

− 0.78755

[2]

2.03E − 05

[3]

2.03E − 05

[4]

− 4.97214

[5]

Down

[6]

Interferon alpha and beta receptor subunit 1

[183] array · 7 items

[0]

LTA

[1]

− 0.56282

[2]

2.17E − 05

[3]

2.17E − 05

[4]

− 4.94915

[5]

Down

[6]

Lymphotoxin alpha

[184] array · 7 items

[0]

FCGR2B

[1]

− 0.85355

[2]

2.4E − 05

[3]

2.4E − 05

[4]

− 4.91443

[5]

Down

[6]

Fc fragment of IgG receptor IIb

[185] array · 7 items

[0]

EGR1

[1]

− 0.63082

[2]

2.41E − 05

[3]

2.41E − 05

[4]

− 4.9133

[5]

Down

[6]

Early growth response 1

[186] array · 7 items

[0]

CD86

[1]

− 0.76691

[2]

2.54E − 05

[3]

2.54E − 05

[4]

− 4.89525

[5]

Down

[6]

CD86 molecule

[187] array · 7 items

[0]

CD82

[1]

− 0.99568

[2]

2.76E − 05

[3]

2.76E − 05

[4]

− 4.86674

[5]

Down

[6]

CD82 molecule

[188] array · 7 items

[0]

CD34

[1]

− 0.56045

[2]

2.79E − 05

[3]

2.79E − 05

[4]

− 4.86293

[5]

Down

[6]

CD34 molecule

[189] array · 7 items

[0]

TRAF3

[1]

− 0.46214

[2]

2.87E − 05

[3]

2.87E − 05

[4]

− 4.85429

[5]

Down

[6]

TNF receptor associated factor 3

[190] array · 7 items

[0]

CTLA4

[1]

− 0.53577

[2]

3E − 05

[3]

3E − 05

[4]

− 4.83886

[5]

Down

[6]

Cytotoxic T-Lymphocyte Associated Protein 4

[191] array · 7 items

[0]

HAMP

[1]

− 0.61205

[2]

3E − 05

[3]

3E − 05

[4]

− 4.83856

[5]

Down

[6]

Hepcidin antimicrobial peptide

[192] array · 7 items

[0]

EGR2

[1]

− 0.78873

[2]

3.15E − 05

[3]

3.15E − 05

[4]

− 4.82228

[5]

Down

[6]

Early growth response 2

[193] array · 7 items

[0]

ICAM5

[1]

− 0.53214

[2]

3.22E − 05

[3]

3.22E − 05

[4]

− 4.81493

[5]

Down

[6]

Intercellular adhesion molecule 5

[194] array · 7 items

[0]

CSF1R

[1]

− 0.70273

[2]

3.45E − 05

[3]

3.45E − 05

[4]

− 4.79056

[5]

Down

[6]

Colony stimulating factor 1 receptor

[195] array · 7 items

[0]

NT5E

[1]

− 0.85836

[2]

3.68E − 05

[3]

3.68E − 05

[4]

− 4.76884

[5]

Down

[6]

5′-nucleotidase ecto

[196] array · 7 items

[0]

IL7

[1]

− 0.74464

[2]

4.3E − 05

[3]

4.3E − 05

[4]

− 4.71548

[5]

Down

[6]

Interleukin 7

[197] array · 7 items

[0]

CTSS

[1]

− 0.62991

[2]

4.34E − 05

[3]

4.34E − 05

[4]

− 4.71277

[5]

Down

[6]

Cathepsin S

[198] array · 7 items

[0]

IL17B

[1]

− 0.55268

[2]

4.82E − 05

[3]

4.82E − 05

[4]

− 4.6769

[5]

Down

[6]

Interleukin 17B

[199] array · 7 items

[0]

CR2

[1]

− 1.00786

[2]

4.86E − 05

[3]

4.86E − 05

[4]

− 4.67369

[5]

Down

[6]

Complement C3d receptor 2

[200] array · 7 items

[0]

CD44

[1]

− 0.35164

[2]

5.25E − 05

[3]

5.25E − 05

[4]

− 4.64701

[5]

Down

[6]

CD44 molecule (Indian blood group)

[201] array · 7 items

[0]

PLA2G2A

[1]

− 0.53655

[2]

5.77E − 05

[3]

5.77E − 05

[4]

− 4.61492

[5]

Down

[6]

Phospholipase A2 group IIA

[202] array · 7 items

[0]

BTK

[1]

− 0.45495

[2]

5.87E − 05

[3]

5.87E − 05

[4]

− 4.60896

[5]

Down

[6]

Bruton tyrosine kinase

[203] array · 7 items

[0]

[1]

− 0.65964

[2]

5.95E − 05

[3]

5.95E − 05

[4]

− 4.60439

[5]

Down

[6]

Complement C6

[204] array · 7 items

[0]

IRGM

[1]

− 0.62291

[2]

6.21E − 05

[3]

6.21E − 05

[4]

− 4.58953

[5]

Down

[6]

Immunity related GTPase M

[205] array · 7 items

[0]

IL22

[1]

− 0.65314

[2]

7.15E − 05

[3]

7.15E − 05

[4]

− 4.54121

[5]

Down

[6]

Interleukin 22

[206] array · 7 items

[0]

CEBPB

[1]

− 0.88709

[2]

7.69E − 05

[3]

7.69E − 05

[4]

− 4.51625

[5]

Down

[6]

CCAAT enhancer binding protein beta

[207] array · 7 items

[0]

IL6

[1]

− 0.69105

[2]

7.91E − 05

[3]

7.91E − 05

[4]

− 4.50639

[5]

Down

[6]

Interleukin 6

[208] array · 7 items

[0]

IFNA2

[1]

− 0.77586

[2]

8.23E − 05

[3]

8.23E − 05

[4]

− 4.49296

[5]

Down

[6]

Interferon alpha 2

[209] array · 7 items

[0]

TGFBR1

[1]

− 0.40336

[2]

8.66E − 05

[3]

8.66E − 05

[4]

− 4.47511

[5]

Down

[6]

Transforming growth factor beta receptor 1

[210] array · 7 items

[0]

IL17F

[1]

− 0.54009

[2]

8.83E − 05

[3]

8.83E − 05

[4]

− 4.4686

[5]

Down

[6]

Interleukin 17F

[211] array · 7 items

[0]

IL28A/B

[1]

− 0.55282

[2]

0.000163

[3]

0.000163

[4]

− 4.25674

[5]

Down

[6]

Interleukin 28A/B

[212] array · 7 items

[0]

IL17A

[1]

− 0.53723

[2]

0.00018

[3]

0.00018

[4]

− 4.22236

[5]

Down

[6]

Interleukin 17A

[213] array · 7 items

[0]

LILRA2

[1]

− 0.68495

[2]

0.000195

[3]

0.000195

[4]

− 4.194

[5]

Down

[6]

Leukocyte immunoglobulin like receptor A2

[214] array · 7 items

[0]

LILRA3

[1]

− 2.33691

[2]

0.000203

[3]

0.000203

[4]

− 4.18055

[5]

Down

[6]

Leukocyte immunoglobulin like receptor A3

[215] array · 7 items

[0]

VCAM1

[1]

− 0.60605

[2]

0.000219

[3]

0.000219

[4]

− 4.15259

[5]

Down

[6]

Vascular cell adhesion molecule 1

[216] array · 7 items

[0]

SPP1

[1]

− 0.6555

[2]

0.000221

[3]

0.000221

[4]

− 4.1496

[5]

Down

[6]

Secreted phosphoprotein 1

[217] array · 7 items

[0]

CARD9

[1]

− 0.55227

[2]

0.000269

[3]

0.000269

[4]

− 4.0818

[5]

Down

[6]

Caspase recruitment domain family member 9

[218] array · 7 items

[0]

LCK

[1]

− 0.40364

[2]

0.000299

[3]

0.000299

[4]

− 4.04398

[5]

Down

[6]

LCK proto-oncogene, Src family tyrosine kinase

[219] array · 7 items

[0]

SELE

[1]

− 0.52332

[2]

0.000306

[3]

0.000306

[4]

− 4.03551

[5]

Down

[6]

selectin E

[220] array · 7 items

[0]

SLC2A1

[1]

− 0.44118

[2]

0.00036

[3]

0.00036

[4]

− 3.97865

[5]

Down

[6]

solute carrier family 2 member 1

[221] array · 7 items

[0]

LIF

[1]

− 0.50555

[2]

0.000368

[3]

0.000368

[4]

− 3.97037

[5]

Down

[6]

LIF interleukin 6 family cytokine

[222] array · 7 items

[0]

IDO1

[1]

− 0.95541

[2]

0.000417

[3]

0.000417

[4]

− 3.92685

[5]

Down

[6]

Indoleamine 2,3-dioxygenase 1

[223] array · 7 items

[0]

TNFRSF10C

[1]

− 0.88564

[2]

0.000471

[3]

0.000471

[4]

− 3.88294

[5]

Down

[6]

TNF receptor superfamily member 10c

[224] array · 7 items

[0]

IL23A

[1]

− 0.87541

[2]

0.000557

[3]

0.000557

[4]

− 3.82374

[5]

Down

[6]

interleukin 23 subunit alpha

[225] array · 7 items

[0]

CD80

[1]

− 0.58964

[2]

0.000567

[3]

0.000567

[4]

− 3.81702

[5]

Down

[6]

CD80 molecule

[226] array · 7 items

[0]

GPR183

[1]

− 1.088

[2]

0.00057

[3]

0.00057

[4]

− 3.81527

[5]

Down

[6]

G protein-coupled receptor 183

[227] array · 7 items

[0]

C1R

[1]

− 0.41727

[2]

0.000592

[3]

0.000592

[4]

− 3.8018

[5]

Down

[6]

Complement C1r

[228] array · 7 items

[0]

CCL11

[1]

− 0.55055

[2]

0.000611

[3]

0.000611

[4]

− 3.79064

[5]

Down

[6]

C–C motif chemokine ligand 11

[229] array · 7 items

[0]

HLA-DPA1

[1]

− 0.6385

[2]

0.000637

[3]

0.000637

[4]

− 3.77577

[5]

Down

[6]

major histocompatibility complex, class II, DP alpha 1

[230] array · 7 items

[0]

IFNG

[1]

− 0.877

[2]

0.00073

[3]

0.00073

[4]

− 3.72658

[5]

Down

[6]

Interferon gamma

[231] array · 7 items

[0]

DUSP4

[1]

− 0.70741

[2]

0.000789

[3]

0.000789

[4]

− 3.69861

[5]

Down

[6]

Dual specificity phosphatase 4

[232] array · 7 items

[0]

IL27

[1]

− 0.44905

[2]

0.000852

[3]

0.000852

[4]

− 3.67089

[5]

Down

[6]

Interleukin 27

[233] array · 7 items

[0]

CD48

[1]

− 1.15805

[2]

0.000953

[3]

0.000953

[4]

− 3.6304

[5]

Down

[6]

CD48 molecule

[234] array · 7 items

[0]

FN1

[1]

− 0.56177

[2]

0.001005

[3]

0.001005

[4]

− 3.61111

[5]

Down

[6]

fibronectin 1

[235] array · 7 items

[0]

CD244

[1]

− 0.39427

[2]

0.001018

[3]

0.001018

[4]

− 3.60646

[5]

Down

[6]

CD244 molecule

[236] array · 7 items

[0]

PPBP

[1]

− 1.35464

[2]

0.001091

[3]

0.001091

[4]

− 3.58105

[5]

Down

[6]

pro-platelet basic protein

[237] array · 7 items

[0]

IL13

[1]

− 0.599

[2]

0.001204

[3]

0.001204

[4]

− 3.54515

[5]

Down

[6]

interleukin 13

[238] array · 7 items

[0]

CCL24

[1]

− 0.45395

[2]

0.001221

[3]

0.001221

[4]

− 3.53987

[5]

Down

[6]

C–C motif chemokine ligand 24

[239] array · 7 items

[0]

GATA3

[1]

− 0.55041

[2]

0.001228

[3]

0.001228

[4]

− 3.53797

[5]

Down

[6]

GATA binding protein 3

[240] array · 7 items

[0]

BID

[1]

− 0.46636

[2]

0.001281

[3]

0.001281

[4]

− 3.52243

[5]

Down

[6]

BH3 interacting domain death agonist

[241] array · 7 items

[0]

BCL2L11

[1]

− 0.40091

[2]

0.001565

[3]

0.001565

[4]

− 3.44881

[5]

Down

[6]

BCL2 like 11

[242] array · 7 items

[0]

KIT

[1]

− 0.52868

[2]

0.001589

[3]

0.001589

[4]

− 3.44316

[5]

Down

[6]

KIT proto-oncogene, receptor tyrosine kinase

[243] array · 7 items

[0]

MME

[1]

− 1.00591

[2]

0.001596

[3]

0.001596

[4]

− 3.44151

[5]

Down

[6]

Membrane metalloendopeptidase

[244] array · 7 items

[0]

ZEB1

[1]

− 0.38082

[2]

0.001667

[3]

0.001667

[4]

− 3.42548

[5]

Down

[6]

Zinc finger E-box binding homeobox 1

[245] array · 7 items

[0]

C4A/B

[1]

− 0.62314

[2]

0.001738

[3]

0.001738

[4]

− 3.40994

[5]

Down

[6]

Complement C4A/B

[246] array · 7 items

[0]

FCAR

[1]

− 0.50423

[2]

0.00198

[3]

0.00198

[4]

− 3.36169

[5]

Down

[6]

Fc fragment of IgA receptor

[247] array · 7 items

[0]

BTLA

[1]

− 0.45623

[2]

0.002033

[3]

0.002033

[4]

− 3.35183

[5]

Down

[6]

B and T lymphocyte associated

[248] array · 7 items

[0]

TAGAP

[1]

− 0.38886

[2]

0.002261

[3]

0.002261

[4]

− 3.31206

[5]

Down

[6]

T cell activation RhoGTPase activating protein

[249] array · 7 items

[0]

CD83

[1]

− 0.39914

[2]

0.002292

[3]

0.002292

[4]

− 3.307

[5]

Down

[6]

CD83 molecule

[250] array · 7 items

[0]

SELPLG

[1]

− 0.37564

[2]

0.002362

[3]

0.002362

[4]

-3.29575

[5]

Down

[6]

Selectin P ligand

[251] array · 7 items

[0]

B3GAT1

[1]

− 0.66791

[2]

0.002423

[3]

0.002423

[4]

− 3.28614

[5]

Down

[6]

Beta-1,3-glucuronyltransferase 1

[252] array · 7 items

[0]

CCRL1

[1]

− 0.39195

[2]

0.002543

[3]

0.002543

[4]

− 3.26788

[5]

Down

[6]

C–C chemokine receptor type 11

[253] array · 7 items

[0]

TNFRSF14

[1]

− 0.29986

[2]

0.002557

[3]

0.002557

[4]

− 3.26588

[5]

Down

[6]

TNF receptor superfamily member 14

[254] array · 7 items

[0]

CSF3R

[1]

− 0.65318

[2]

0.003003

[3]

0.003003

[4]

− 3.20507

[5]

Down

[6]

Colony stimulating factor 3 receptor

[255] array · 7 items

[0]

CD9

[1]

− 0.87091

[2]

0.003004

[3]

0.003004

[4]

− 3.20497

[5]

Down

[6]

CD9 molecule

[256] array · 7 items

[0]

C1S

[1]

− 0.52059

[2]

0.003211

[3]

0.003211

[4]

− 3.17969

[5]

Down

[6]

complement C1s

[257] array · 7 items

[0]

PECAM1

[1]

− 0.30873

[2]

0.003251

[3]

0.003251

[4]

− 3.17496

[5]

Down

[6]

platelet and endothelial cell adhesion molecule 1

[258] array · 7 items

[0]

DEFB103B

[1]

− 0.4315

[2]

0.003466

[3]

0.003466

[4]

− 3.15055

[5]

Down

[6]

Defensin beta 103B

[259] array · 7 items

[0]

ITLN1

[1]

− 1.17682

[2]

0.003488

[3]

0.003488

[4]

− 3.14815

[5]

Down

[6]

Intelectin 1

[260] array · 7 items

[0]

CXCL13

[1]

− 0.46586

[2]

0.003554

[3]

0.003554

[4]

− 3.14101

[5]

Down

[6]

C-X-C motif chemokine ligand 13

[261] array · 7 items

[0]

RAG1

[1]

− 0.47836

[2]

0.003917

[3]

0.003917

[4]

− 3.10376

[5]

Down

[6]

Recombination activating 1

[262] array · 7 items

[0]

TNFRSF4

[1]

− 0.55123

[2]

0.004154

[3]

0.004154

[4]

− 3.08112

[5]

Down

[6]

TNF receptor superfamily member 4

[263] array · 7 items

[0]

C14orf166

[1]

− 0.35727

[2]

0.004255

[3]

0.004255

[4]

− 3.07189

[5]

Down

[6]

Chromosome 14 open reading frame 166

[264] array · 7 items

[0]

IL10RA

[1]

− 0.26059

[2]

0.004423

[3]

0.004423

[4]

− 3.0569

[5]

Down

[6]

Interleukin 10 receptor subunit alpha

[265] array · 7 items

[0]

POU2F2

[1]

− 0.292

[2]

0.004614

[3]

0.004614

[4]

− 3.04059

[5]

Down

[6]

POU class 2 homeobox 2

[266] array · 7 items

[0]

[1]

− 0.41223

[2]

0.004688

[3]

0.004688

[4]

− 3.03441

[5]

Down

[6]

complement C7

[267] array · 7 items

[0]

RORC

[1]

− 0.52768

[2]

0.005006

[3]

0.005006

[4]

− 3.00891

[5]

Down

[6]

RAR related orphan receptor C

[268] array · 7 items

[0]

CXCL11

[1]

− 0.83891

[2]

0.005151

[3]

0.005151

[4]

− 2.99784

[5]

Down

[6]

C-X-C motif chemokine ligand 11

[269] array · 7 items

[0]

MASP1

[1]

− 0.50677

[2]

0.005182

[3]

0.005182

[4]

− 2.99543

[5]

Down

[6]

Mannan binding lectin serine peptidase 1

[270] array · 7 items

[0]

MAP4K4

[1]

− 0.37777

[2]

0.005449

[3]

0.005449

[4]

− 2.97583

[5]

Down

[6]

Mitogen-activated protein kinase kinasekinasekinase 4

[271] array · 7 items

[0]

CX3CL1

[1]

− 0.50445

[2]

0.005597

[3]

0.005597

[4]

− 2.96535

[5]

Down

[6]

C-X3-C motif chemokine ligand 1

[272] array · 7 items

[0]

BATF3

[1]

− 0.62586

[2]

0.005862

[3]

0.005862

[4]

− 2.94725

[5]

Down

[6]

Basic leucine zipper ATF-like transcription factor 3

[273] array · 7 items

[0]

CCR8

[1]

− 0.51627

[2]

0.005946

[3]

0.005946

[4]

− 2.94164

[5]

Down

[6]

C–C motif chemokine receptor 8

[274] array · 7 items

[0]

TAL1

[1]

− 1.01455

[2]

0.006016

[3]

0.006016

[4]

− 2.93707

[5]

Down

[6]

TAL bHLH transcription factor 1, erythroid differentiation factor

[275] array · 7 items

[0]

NFIL3

[1]

− 0.723

[2]

0.007

[3]

0.007

[4]

− 2.87725

[5]

Down

[6]

Nuclear factor, interleukin 3 regulated

[276] array · 7 items

[0]

CD8A

[1]

− 0.50595

[2]

0.007337

[3]

0.007337

[4]

− 2.85858

[5]

Down

[6]

CD8a molecule

[277] array · 7 items

[0]

CLEC6A

[1]

− 0.62323

[2]

0.007445

[3]

0.007445

[4]

− 2.85274

[5]

Down

[6]

C-type lectin domain containing 6A

[278] array · 7 items

[0]

TCF4

[1]

− 0.37827

[2]

0.007904

[3]

0.007904

[4]

− 2.8289

[5]

Down

[6]

Transcription factor 4

[279] array · 7 items

[0]

FCGR2A

[1]

− 0.664

[2]

0.009089

[3]

0.009089

[4]

− 2.77283

[5]

Down

[6]

Fc fragment of IgG receptor IIa

[280] array · 7 items

[0]

HLA-B

[1]

− 0.31677

[2]

0.00918

[3]

0.00918

[4]

− 2.76877

[5]

Down

[6]

major histocompatibility complex, class I, B

[281] array · 7 items

[0]

IRF8

[1]

− 0.39477

[2]

0.009346

[3]

0.009346

[4]

− 2.76157

[5]

Down

[6]

Interferon regulatory factor 8

[282] array · 7 items

[0]

MAPK11

[1]

− 0.60427

[2]

0.010152

[3]

0.010152

[4]

− 2.72804

[5]

Down

[6]

Mitogen-activated protein kinase 11

[283] array · 7 items

[0]

ILF3

[1]

− 0.17055

[2]

0.010366

[3]

0.010366

[4]

− 2.71958

[5]

Down

[6]

Interleukin enhancer binding factor 3

[284] array · 7 items

[0]

XCR1

[1]

− 0.34541

[2]

0.01065

[3]

0.01065

[4]

− 2.70856

[5]

Down

[6]

X–C motif chemokine receptor 1

[285] array · 7 items

[0]

ITGAE

[1]

− 0.33509

[2]

0.011424

[3]

0.011424

[4]

− 2.67988

[5]

Down

[6]

Integrin subunit alpha E

[286] array · 7 items

[0]

IL4R

[1]

− 0.69064

[2]

0.012538

[3]

0.012538

[4]

− 2.64162

[5]

Down

[6]

Interleukin 4 receptor

[287] array · 7 items

[0]

CTSC

[1]

− 0.16718

[2]

0.012619

[3]

0.012619

[4]

− 2.63897

[5]

Down

[6]

Cathepsin C

[288] array · 7 items

[0]

ETS1

[1]

− 0.39405

[2]

0.013255

[3]

0.013255

[4]

− 2.61865

[5]

Down

[6]

ETS proto-oncogene 1, transcription factor

[289] array · 7 items

[0]

CFI

[1]

− 0.30082

[2]

0.013335

[3]

0.013335

[4]

− 2.61614

[5]

Down

[6]

Complement factor I

[290] array · 7 items

[0]

STAT5A

[1]

− 0.27168

[2]

0.014802

[3]

0.014802

[4]

− 2.57273

[5]

Down

[6]

Signal transducer and activator of transcription 5A

[291] array · 7 items

[0]

C8A

[1]

− 0.37964

[2]

0.016204

[3]

0.016204

[4]

− 2.53478

[5]

Down

[6]

Complement C8 alpha chain

[292] array · 7 items

[0]

DEFB4A

[1]

− 0.36691

[2]

0.017835

[3]

0.017835

[4]

− 2.49428

[5]

Down

[6]

Defensin beta 4A

[293] array · 7 items

[0]

RELB

[1]

− 0.45095

[2]

0.019351

[3]

0.019351

[4]

− 2.45958

[5]

Down

[6]

RELB proto-oncogene, NF-kB subunit

[294] array · 7 items

[0]

ATG7

[1]

− 0.32859

[2]

0.01984

[3]

0.01984

[4]

− 2.4489

[5]

Down

[6]

Autophagy related 7

[295] array · 7 items

[0]

DPP4

[1]

− 0.38823

[2]

0.01999

[3]

0.01999

[4]

− 2.44568

[5]

Down

[6]

Dipeptidyl peptidase 4

[296] array · 7 items

[0]

GPI

[1]

− 0.21382

[2]

0.020424

[3]

0.020424

[4]

− 2.43646

[5]

Down

[6]

Glucose-6-phosphate isomerase

[297] array · 7 items

[0]

CD59

[1]

− 0.24032

[2]

0.020561

[3]

0.020561

[4]

− 2.43359

[5]

Down

[6]

CD59 molecule (CD59 blood group)

[298] array · 7 items

[0]

CASP3

[1]

− 0.40573

[2]

0.025629

[3]

0.025629

[4]

− 2.33807

[5]

Down

[6]

Caspase 3

[299] array · 7 items

[0]

TIGIT

[1]

− 0.3615

[2]

0.025963

[3]

0.025963

[4]

− 2.33239

[5]

Down

[6]

T cell immunoreceptor with Ig and ITIM domains

[300] array · 7 items

[0]

CFD

[1]

− 0.36627

[2]

0.026073

[3]

0.026073

[4]

− 2.33053

[5]

Down

[6]

Complement factor D

[301] array · 7 items

[0]

CCL18

[1]

− 0.42077

[2]

0.026944

[3]

0.026944

[4]

− 2.3161

[5]

Down

[6]

C–C motif chemokine ligand 18

[302] array · 7 items

[0]

PLAU

[1]

− 0.34086

[2]

0.028132

[3]

0.028132

[4]

− 2.29706

[5]

Down

[6]

Plasminogen activator, urokinase

[303] array · 7 items

[0]

PTPN22

[1]

− 0.20086

[2]

0.028829

[3]

0.028829

[4]

− 2.28623

[5]

Down

[6]

Protein tyrosine phosphatase non-receptor type 22

[304] array · 7 items

[0]

TOLLIP

[1]

− 0.27377

[2]

0.028911

[3]

0.028911

[4]

− 2.28497

[5]

Down

[6]

Toll interacting protein

[305] array · 7 items

[0]

CXCR2

[1]

− 0.49195

[2]

0.029438

[3]

0.029438

[4]

− 2.27696

[5]

Down

[6]

C-X-C motif chemokine receptor 2

[306] array · 7 items

[0]

CCL20

[1]

− 0.34555

[2]

0.029871

[3]

0.029871

[4]

− 2.27048

[5]

Down

[6]

C–C motif chemokine ligand 20

[307] array · 7 items

[0]

IL12A

[1]

− 0.40759

[2]

0.03046

[3]

0.03046

[4]

− 2.26179

[5]

Down

[6]

Interleukin 12A

[308] array · 7 items

[0]

IL10

[1]

− 0.33555

[2]

0.03205

[3]

0.03205

[4]

− 2.23904

[5]

Down

[6]

Interleukin 10

[309] array · 7 items

[0]

LILRA1

[1]

− 0.26991

[2]

0.033542

[3]

0.033542

[4]

− 2.21862

[5]

Down

[6]

leukocyte immunoglobulin like receptor A1

[310] array · 7 items

[0]

PTPN6

[1]

− 0.16109

[2]

0.034722

[3]

0.034722

[4]

− 2.20304

[5]

Down

[6]

protein tyrosine phosphatase non-receptor type 6

[311] array · 7 items

[0]

CCL19

[1]

− 0.37718

[2]

0.035605

[3]

0.035605

[4]

− 2.19168

[5]

Down

[6]

C–C motif chemokine ligand 19

[312] array · 7 items

[0]

IKBKAP

[1]

− 0.15505

[2]

0.035624

[3]

0.035624

[4]

− 2.19144

[5]

Down

[6]

IκB kinase complex-associated protein

[313] array · 7 items

[0]

TNFRSF9

[1]

− 0.50786

[2]

0.036235

[3]

0.036235

[4]

− 2.18372

[5]

Down

[6]

TNF receptor superfamily member 9

[314] array · 7 items

[0]

TCF7

[1]

− 0.60091

[2]

0.036564

[3]

0.036564

[4]

− 2.17963

[5]

Down

[6]

Transcription factor 7

[315] array · 7 items

[0]

HLA-DMA

[1]

− 0.30777

[2]

0.036925

[3]

0.036925

[4]

− 2.17516

[5]

Down

[6]

Major histocompatibility complex, class II, DM alpha

[316] array · 7 items

[0]

CXCL12

[1]

− 0.69291

[2]

0.037168

[3]

0.037168

[4]

− 2.17218

[5]

Down

[6]

C-X-C motif chemokine ligand 12

[317] array · 7 items

[0]

MBL2

[1]

− 0.37009

[2]

0.037623

[3]

0.037623

[4]

− 2.16664

[5]

Down

[6]

Mannose binding lectin 2

[318] array · 7 items

[0]

IKZF2

[1]

− 0.46655

[2]

0.039489

[3]

0.039489

[4]

− 2.14452

[5]

Down

[6]

IKAROS family zinc finger 2

[319] array · 7 items

[0]

BCAP31

[1]

− 0.10632

[2]

0.04075

[3]

0.04075

[4]

− 2.13009

[5]

Down

[6]

B cell receptor associated protein 31

[320] array · 7 items

[0]

HLA-DRB1

[1]

− 1.39495

[2]

0.041403

[3]

0.041403

[4]

− 2.12278

[5]

Down

[6]

Major histocompatibility complex, class II, DR beta 1

[321] array · 7 items

[0]

IRAK4

[1]

− 0.23727

[2]

0.041428

[3]

0.041428

[4]

− 2.12251

[5]

Down

[6]

Interleukin 1 receptor associated kinase 4

[322] array · 7 items

[0]

CXCR1

[1]

− 0.49741

[2]

0.041833

[3]

0.041833

[4]

− 2.11802

[5]

Down

[6]

C-X-C motif chemokine receptor 1

[323] array · 7 items

[0]

PTK2

[1]

− 0.33609

[2]

0.043242

[3]

0.043242

[4]

− 2.10272

[5]

Down

[6]

Protein tyrosine kinase 2

[324] array · 7 items

[0]

CD45R0

[1]

− 0.46514

[2]

0.043373

[3]

0.043373

[4]

− 2.10132

[5]

Down

[6]

A member of leucocyte common antigen family

row_count

325

column_count

numeric_cells

1605

header_rows

locator

section[12]/table-wrap[1]#Tab1

[3] object · 16 fields

asset:table:pmid:33251083:2

role

table

format

jats-table

media_type

application/vnd.jats.table+json

uri

null

sha256

sha256:b7239eaa56eb9da9deefd70f1c000d77539072c6a251173f715314d5547a318e

bytes

10374

access

open

state

verified

reader

read_table

reader_status

available

identifier

section[13]/table-wrap[1]#Tab2

version

null

note

The enriched pathway terms of the up regulated differentially expressed genes

structure object · 5 fields

pmcid

PMC7679428

section_index

section_title

Pathway enrichment analysis for DEGs

row_count

column_count

table object · 8 fields

label

Table 2

caption

The enriched pathway terms of the up regulated differentially expressed genes

rows array · 73 items

[0] array · 1 item

[0]

KEGG

[1] array · 8 items

[0]

Pathway ID

[1]

Pathway Name

[2]

P-value

[3]

FDR B&H

[4]

FDR B&Y

[5]

Bonferroni

[6]

Gene Count

[7]

Gene

[2] array · 8 items

[0]

213306

[1]

Measles

[2]

3.21E − 17

[3]

4.46E − 15

[4]

2.46E − 14

[5]

4.46E − 15

[6]

[7]

CCND3, JAK1, JAK2, IFIH1, TRAF6, IKBKE, TLR2, IRF7, FYN, IL2RG, STAT1, TP53, STAT3, MX1, STAT5B, IFNAR2

[3] array · 8 items

[0]

377873

[1]

Herpes simplex infection

[2]

1.19E − 13

[3]

8.24E − 12

[4]

4.54E − 11

[5]

1.65E − 11

[6]

[7]

JAK1, JAK2, IFIH1, TRAF2, TRAF6, HLA-A, IKBKE, TLR2, C1QBP, CCL5, IRF7, IKBKB, STAT1, TP53, IFNAR2

[4] array · 8 items

[0]

83079

[1]

Natural killer cell mediated cytotoxicity

[2]

5.40E − 13

[3]

2.50E − 11

[4]

1.38E − 10

[5]

7.51E − 11

[6]

[7]

KLRK1, CD247, HLA-A, GZMB, HRAS, LCP2, ITGAL, FYN, ITGB2, KLRC1, ZAP70, KLRD1, IFNAR2

[5] array · 8 items

[0]

193147

[1]

Osteoclast differentiation

[2]

1.85E − 10

[3]

3.32E − 09

[4]

1.83E − 08

[5]

2.57E − 08

[6]

[7]

JAK1, TRAF2, TRAF6, LILRB2, LILRA6, SOCS1, IKBKB, LCP2, FYN, STAT1, IFNAR2

[6] array · 8 items

[0]

83077

[1]

Jak-STAT signaling pathway

[2]

1.31E − 09

[3]

1.83E − 08

[4]

1.01E − 07

[5]

1.83E − 07

[6]

[7]

CCND3, JAK1, JAK2, HRAS, SOCS1, IL2RG, STAT1, STAT3, STAT4, STAT5B, IFNAR2

[7] array · 8 items

[0]

217173

[1]

Influenza A

[2]

3.94E − 09

[3]

4.56E − 08

[4]

2.51E − 07

[5]

5.47E − 07

[6]

[7]

JAK1, JAK2, IFIH1, IKBKE, CCL5, IRF7, IKBKB, STAT1, NLRP3, MX1, IFNAR2

[8] array · 8 items

[0]

373901

[1]

HTLV-I infection

[2]

2.27E − 08

[3]

2.11E − 07

[4]

1.16E − 06

[5]

3.16E − 06

[6]

[7]

CCND3, JAK1, HLA-A, HRAS, XBP1, CTNNB1, IKBKB, ITGAL, ITGB2, IL2RG, TP53, STAT5B

[9] array · 8 items

[0]

658418

[1]

Viral carcinogenesis

[2]

2.16E − 07

[3]

1.67E − 06

[4]

9.20E − 06

[5]

3.00E − 05

[6]

[7]

CCND3, JAK1, TRAF2, HLA-A, HRAS, IRF7, CCR5, TP53, STAT3, STAT5B

[10] array · 8 items

[0]

83080

[1]

T cell receptor signaling pathway

[2]

2.05E − 06

[3]

1.36E − 05

[4]

7.47E − 05

[5]

2.85E − 04

[6]

[7]

PDCD1, CD247, HRAS, IKBKB, LCP2, FYN, ZAP70

[11] array · 8 items

[0]

125138

[1]

Viral myocarditis

[2]

2.21E − 05

[3]

1.18E − 04

[4]

6.51E − 04

[5]

3.07E − 03

[6]

[7]

ABL1, HLA-A, ITGAL, FYN, ITGB2

[12] array · 8 items

[0]

213780

[1]

Tuberculosis

[2]

7.57E − 05

[3]

3.63E − 04

[4]

2.00E − 03

[5]

1.05E − 02

[6]

[7]

JAK1, JAK2, TRAF6, TLR2, CLEC7A, ITGB2, STAT1

[13] array · 8 items

[0]

83051

[1]

Cytokine-cytokine receptor interaction

[2]

1.59E − 04

[3]

6.69E − 04

[4]

3.69E − 03

[5]

2.21E − 02

[6]

[7]

CCR1, CCL5, CCR5, IL18RAP, IL2RG, IL18R1, CX3CR1, IFNAR2

[14] array · 8 items

[0]

152665

[1]

Malaria

[2]

1.79E − 04

[3]

7.32E − 04

[4]

4.04E − 03

[5]

2.49E − 02

[6]

[7]

KLRK1, TLR2, ITGAL, ITGB2

[15] array · 1 item

[0]

Pathway interaction database

[16] array · 8 items

[0]

137922

[1]

IL12-mediated signaling events

[2]

1.37E − 17

[3]

1.56E − 15

[4]

8.29E − 15

[5]

1.56E − 15

[6]

[7]

JAK2, CD247, HLA-A, TBX21, GZMB, SOCS1, CCR5, IL18RAP, IL2RG, IL18R1, STAT1, STAT3, STAT4

[17] array · 8 items

[0]

137976

[1]

IL2-mediated signaling events

[2]

5.15E − 10

[3]

2.94E − 08

[4]

1.56E − 07

[5]

5.88E − 08

[6]

[7]

JAK1, IKZF3, SOCS1, FYN, IL2RG, STAT1, STAT3, STAT5B

[18] array · 8 items

[0]

138055

[1]

TCR signaling in naive CD8 + T cells

[2]

9.79E − 09

[3]

2.35E − 07

[4]

1.25E − 06

[5]

1.12E − 06

[6]

[7]

TRAF6, CD247, HLA-A, IKBKB, LCP2, FYN, ZAP70

[19] array · 8 items

[0]

138071

[1]

PDGFR-beta signaling pathway

[2]

6.28E − 07

[3]

7.16E − 06

[4]

3.81E − 05

[5]

7.16E − 05

[6]

[7]

ABL1, HRAS, FYN, STAT1, STAT3, STAT5B

[20] array · 8 items

[0]

137988

[1]

IL2 signaling events mediated by STAT5

[2]

2.52E − 05

[3]

2.21E − 04

[4]

1.17E − 03

[5]

2.87E − 03

[6]

[7]

CCND3, JAK1, IL2RG, STAT5B

[21] array · 8 items

[0]

138019

[1]

p75(NTR)-mediated signaling

[2]

5.25E − 03

[3]

2.32E − 02

[4]

1.23E − 01

[5]

5.99E − 01

[6]

[7]

TRAF6, IKBKB, TP53

[22] array · 8 items

[0]

138021

[1]

Paxillin-dependent events mediated by a4b1

[2]

5.29E − 03

[3]

2.32E − 02

[4]

1.23E − 01

[5]

6.03E − 01

[6]

[7]

ITGAL, ITGB2

[23] array · 8 items

[0]

137940

[1]

Signaling events mediated by VEGFR1 and VEGFR2

[2]

5.75E − 03

[3]

2.43E − 02

[4]

1.29E − 01

[5]

6.55E − 01

[6]

[7]

HRAS, CTNNB1, FYN

[24] array · 8 items

[0]

137983

[1]

ALK2 signaling events

[2]

6.18E − 02

[3]

1.22E − 01

[4]

6.47E − 01

[5]

1.00E + 00

[6]

[7]

SMAD5

[25] array · 8 items

[0]

138046

[1]

Syndecan-1-mediated signaling events

[2]

9.40E − 02

[3]

1.70E − 01

[4]

9.04E − 01

[5]

1.00E + 00

[6]

[7]

CCL5

[26] array · 1 item

[0]

REACTOME

[27] array · 8 items

[0]

1269310

[1]

Cytokine Signaling in Immune system

[2]

3.94E − 16

[3]

2.05E − 13

[4]

1.40E − 12

[5]

2.05E − 13

[6]

[7]

JAK1, JAK2, TRAF2, TRAF6, HLA-A, BST2, HRAS, PSMB9, GBP1, SOCS1, CCR1, IRF5, CCL5, IRF7, CCR5, IKBKB, FYN, IFI35, IL18RAP, ITGB2, IL2RG, IL18R1, STAT1, TP53, STAT3, MX1, STAT5B, IFNAR2

[28] array · 8 items

[0]

1269203

[1]

Innate Immune System

[2]

1.61E − 13

[3]

4.19E − 11

[4]

2.86E − 10

[5]

8.38E − 11

[6]

[7]

KLRK1, ATG5, JAK1, JAK2, IFIH1, TRAF2, TRAF6, CD247, ABL1, HLA-A, IKBKE, BST2, LILRB2, TLR2, HRAS, PSMB9, CLEC7A, SOCS1, C2, IRF7, GNLY, CTNNB1, IKBKB, LCP2, ITGAL, FYN, ITGB2, IL2RG, KLRD1, TP53, NLRP3, CEACAM1

[29] array · 8 items

[0]

1269318

[1]

Signaling by Interleukins

[2]

9.69E − 11

[3]

1.06E − 08

[4]

7.24E − 08

[5]

5.04E − 08

[6]

[7]

JAK1, JAK2, TRAF6, HRAS, PSMB9, SOCS1, CCR1, CCL5, CCR5, IKBKB, FYN, IL18RAP, ITGB2, IL2RG, IL18R1, STAT1, TP53, STAT3, STAT5B

[30] array · 8 items

[0]

1269171

[1]

Adaptive Immune System

[2]

1.02E − 10

[3]

1.06E − 08

[4]

7.24E − 08

[5]

5.30E − 08

[6]

[7]

KLRK1, PDCD1, TRAF6, CD247, ZBTB16, HLA-A, LILRB2, TLR2, LAG3, HRAS, LILRA6, PSMB9, SOCS1, SLAMF7, IKBKB, LCP2, ITGAL, FYN, ITGB2, KLRC1, ZAP70, KLRD1, TP53

[31] array · 8 items

[0]

1269340

[1]

Hemostasis

[2]

5.49E − 07

[3]

2.20E − 05

[4]

1.50E − 04

[5]

2.86E − 04

[6]

[7]

JAK1, JAK2, ABL1, CD99, HRAS, C1QBP, SERPING1, IRF7, LCP2, ITGAL, FYN, ITGB2, IL2RG, TP53, CEACAM1, GP1BB

[32] array · 8 items

[0]

1269260

[1]

TRAF3-dependent IRF activation pathway

[2]

9.84E − 05

[3]

1.55E − 03

[4]

1.06E − 02

[5]

5.12E − 02

[6]

[7]

IFIH1, IKBKE, IRF7

[33] array · 8 items

[0]

1268854

[1]

Disease

[2]

1.26E − 03

[3]

1.24E − 02

[4]

8.44E − 02

[5]

6.55E − 01

[6]

[7]

JAK2, CD247, HLA-A, TLR2, HRAS, PSMB9, CCR5, CTNNB1, IKBKB, FYN, STAT1, STAT3, STAT5B

[34] array · 8 items

[0]

1268855

[1]

Diseases of signal transduction

[2]

1.35E − 03

[3]

1.30E − 02

[4]

8.90E − 02

[5]

7.03E − 01

[6]

[7]

JAK2, HRAS, PSMB9, CTNNB1, FYN, STAT1, STAT3, STAT5B

[35] array · 8 items

[0]

1269562

[1]

Leukotriene receptors

[2]

2.86E − 02

[3]

8.96E − 02

[4]

6.12E − 01

[5]

1.00E + 00

[6]

[7]

LTB4R

[36] array · 8 items

[0]

1269248

[1]

Activation of C3 and C5

[2]

3.98E − 02

[3]

1.18E − 01

[4]

8.08E − 01

[5]

1.00E + 00

[6]

[7]

[37] array · 1 item

[0]

MSigDB C2 BIOCARTA (v6.0)

[38] array · 8 items

[0]

M8066

[1]

IL22 Soluble Receptor Signaling Pathway

[2]

2.31E − 10

[3]

3.56E − 08

[4]

2.00E − 07

[5]

3.56E − 08

[6]

[7]

JAK1, JAK2, STAT1, STAT3, STAT4, STAT5B

[39] array · 8 items

[0]

M13494

[1]

Bioactive Peptide Induced Signaling Pathway

[2]

4.38E − 09

[3]

3.38E − 07

[4]

1.90E − 06

[5]

6.75E − 07

[6]

[7]

JAK2, HRAS, FYN, STAT1, STAT3, STAT4, STAT5B

[40] array · 8 items

[0]

M1462

[1]

CTL mediated immune response against target cells

[2]

1.61E − 08

[3]

7.50E − 07

[4]

4.21E − 06

[5]

2.48E − 06

[6]

[7]

CD247, HLA-A, GZMB, ITGAL, ITGB2

[41] array · 8 items

[0]

M6231

[1]

NO2-dependent IL 12 Pathway in NK cells

[2]

2.31E − 06

[3]

3.24E − 05

[4]

1.82E − 04

[5]

3.56E − 04

[6]

[7]

JAK2, CD247, CCR5, STAT4

[42] array · 8 items

[0]

M13863

[1]

MAPKinaseSignaling Pathway

[2]

1.06E − 05

[3]

1.08E − 04

[4]

6.09E − 04

[5]

1.63E − 03

[6]

[7]

TRAF2, MAP4K1, HRAS, IKBKB, MAP4K2, STAT1

[43] array · 8 items

[0]

M6427

[1]

T Helper Cell Surface Molecules

[2]

6.45E − 05

[3]

4.73E − 04

[4]

2.66E − 03

[5]

9.93E − 03

[6]

[7]

CD247, ITGAL, ITGB2

[44] array · 8 items

[0]

M4047

[1]

Selective expression of chemokine receptors during T-cell polarization

[2]

6.08E − 04

[3]

3.12E − 03

[4]

1.75E − 02

[5]

9.37E − 02

[6]

[7]

CCR1, CCR5, IL18R1

[45] array · 8 items

[0]

M11358

[1]

Tumor Suppressor Arf Inhibits Ribosomal Biogenesis

[2]

4.24E − 03

[3]

1.28E − 02

[4]

7.19E − 02

[5]

6.53E − 01

[6]

[7]

ABL1, TP53

[46] array · 8 items

[0]

M17400

[1]

ALK in cardiac myocytes

[2]

1.93E − 02

[3]

4.37E − 02

[4]

2.45E − 01

[5]

1.00E + 00

[6]

[7]

CTNNB1, SMAD5

[47] array · 8 items

[0]

M5885

[1]

Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors

[2]

8.19E − 01

[3]

8.30E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

CLEC7A, SERPING1, CCL5

[48] array · 1 item

[0]

Panther DB

[49] array · 8 items

[0]

P00038

[1]

JAK/STAT signaling pathway

[2]

1.76E − 12

[3]

5.64E − 11

[4]

2.29E − 10

[5]

5.64E − 11

[6]

[7]

JAK1, JAK2, SOCS1, STAT1, STAT3, STAT4, STAT5B

[50] array · 8 items

[0]

P00031

[1]

Inflammation mediated by chemokine and cytokine signaling pathway

[2]

1.44E − 06

[3]

2.31E − 05

[4]

9.37E − 05

[5]

4.62E − 05

[6]

[7]

JAK2, CCRL2, CCR1, CCL5, CCR5, IKBKB, ITGAL, CX3CR1, STAT3

[51] array · 8 items

[0]

P00054

[1]

Toll receptor signaling pathway

[2]

1.94E − 04

[3]

1.03E − 03

[4]

4.19E − 03

[5]

6.20E − 03

[6]

[7]

TRAF6, IKBKE, TLR2, IKBKB

[52] array · 8 items

[0]

P00006

[1]

Apoptosis signaling pathway

[2]

3.03E − 04

[3]

1.39E − 03

[4]

5.62E − 03

[5]

9.69E − 03

[6]

[7]

TRAF2, GZMB, IKBKB, MAP4K2, TP53

[53] array · 8 items

[0]

P00010

[1]

B cell activation

[2]

4.43E − 02

[3]

9.45E − 02

[4]

3.83E − 01

[5]

1.00E + 00

[6]

[7]

HRAS, IKBKB

[54] array · 8 items

[0]

P00052

[1]

TGF-beta signaling pathway

[2]

9.73E − 02

[3]

1.67E − 01

[4]

6.78E − 01

[5]

1.00E + 00

[6]

[7]

HRAS, SMAD5

[55] array · 8 items

[0]

P00011

[1]

Blood coagulation

[2]

2.07E − 01

[3]

2.89E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

GP1BB

[56] array · 8 items

[0]

P00012

[1]

Cadherin signaling pathway

[2]

2.34E − 01

[3]

3.00E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

CTNNB1, FYN

[57] array · 8 items

[0]

P00057

[1]

Wntsignaling pathway

[2]

2.59E − 01

[3]

3.07E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

CTNNB1, TP53, SMAD5

[58] array · 8 items

[0]

P00056

[1]

VEGF signaling pathway

[2]

2.86E − 01

[3]

3.27E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

HRAS

[59] array · 1 item

[0]

Pathway Ontology

[60] array · 8 items

[0]

PW:0000125

[1]

G protein signaling

[2]

5.82E − 03

[3]

3.10E − 02

[4]

1.26E − 01

[5]

1.86E − 01

[6]

[7]

LTB4R

[61] array · 8 items

[0]

PW:0000297

[1]

platelet-derived growth factor signaling

[2]

5.82E − 03

[3]

3.10E − 02

[4]

1.26E − 01

[5]

1.86E − 01

[6]

[7]

JAK2

[62] array · 8 items

[0]

PW:0000143

[1]

insulin signaling

[2]

1.05E − 02

[3]

3.36E − 02

[4]

1.36E − 01

[5]

3.37E − 01

[6]

[7]

SOCS1, STAT5B

[63] array · 8 items

[0]

PW:0000330

[1]

Bone morphogenetic proteins signaling

[2]

2.86E − 02

[3]

6.53E − 02

[4]

2.65E − 01

[5]

9.15E − 01

[6]

[7]

SMAD5

[64] array · 8 items

[0]

PW:0000599

[1]

altered canonical Wntsignaling

[2]

2.86E − 02

[3]

6.53E − 02

[4]

2.65E − 01

[5]

9.15E − 01

[6]

[7]

CTNNB1

[65] array · 8 items

[0]

PW:0000508

[1]

platelet aggregation

[2]

3.42E − 02

[3]

6.84E − 02

[4]

2.78E − 01

[5]

1.00E + 00

[6]

[7]

GP1BB

[66] array · 8 items

[0]

PW:0000234

[1]

innate immune response

[2]

6.18E − 02

[3]

1.10E − 01

[4]

4.46E − 01

[5]

1.00E + 00

[6]

[7]

TLR2

[67] array · 8 items

[0]

PW:0000278

[1]

autophagy

[2]

1.04E − 01

[3]

1.39E − 01

[4]

5.65E − 01

[5]

1.00E + 00

[6]

[7]

ATG10

[68] array · 8 items

[0]

PW:0000243

[1]

vascular endothelial growth factor signaling

[2]

1.30E − 01

[3]

1.49E − 01

[4]

6.03E − 01

[5]

1.00E + 00

[6]

[7]

FYN

[69] array · 8 items

[0]

PW:0000490

[1]

transforming growth factor-beta Smad dependent signaling

[2]

1.40E − 01

[3]

1.55E − 01

[4]

6.28E − 01

[5]

1.00E + 00

[6]

[7]

RUNX1

[70] array · 1 item

[0]

SMPDB

[71] array · 8 items

[0]

SMP00320

[1]

Intracellular Signalling Through Adenosine Receptor A2a and Adenosine

[2]

1.55E − 02

[3]

2.46E − 02

[4]

4.52E − 02

[5]

4.65E − 02

[6]

[7]

HRAS, IKBKB

[72] array · 8 items

[0]

SMP00391

[1]

Insulin Signalling

[2]

1.89E − 01

[3]

1.89E − 01

[4]

3.46E − 01

[5]

5.66E − 01

[6]

[7]

HRAS

row_count

column_count

numeric_cells

420

header_rows

locator

section[13]/table-wrap[1]#Tab2

[4] object · 16 fields

asset:table:pmid:33251083:3

role

table

format

jats-table

media_type

application/vnd.jats.table+json

uri

null

sha256

sha256:307d19ecb0dfe452f834715a6c814a8c922a41eba5ff771952acf5734e1660b5

bytes

17321

access

open

state

verified

reader

read_table

reader_status

available

identifier

section[13]/table-wrap[2]#Tab3

version

null

note

The enriched pathway terms of the down regulated differentially expressed genes

structure object · 5 fields

pmcid

PMC7679428

section_index

section_title

Pathway enrichment analysis for DEGs

row_count

column_count

table object · 8 fields

label

Table 3

caption

The enriched pathway terms of the down regulated differentially expressed genes

rows array · 91 items

[0] array · 8 items

[0]

BIOCYC

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[1] array · 8 items

[0]

Pathway ID

[1]

Pathway Name

[2]

P-value

[3]

FDR B&H

[4]

FDR B&Y

[5]

Bonferroni

[6]

Gene Count

[7]

Gene

[2] array · 8 items

[0]

703092

[1]

Citrulline-nitric oxide cycle

[2]

8.83E − 02

[3]

2.53E − 01

[4]

8.24E − 01

[5]

1.00E + 00

[6]

[7]

NOS2

[3] array · 8 items

[0]

142419

[1]

Phospholipases

[2]

9.82E − 02

[3]

2.53E − 01

[4]

8.24E − 01

[5]

1.00E + 00

[6]

[7]

PLA2G2E, PLA2G2A

[4] array · 8 items

[0]

545273

[1]

Glycoaminoglycan-protein linkage region biosynthesis

[2]

1.05E − 01

[3]

2.53E − 01

[4]

8.24E − 01

[5]

1.00E + 00

[6]

[7]

B3GAT1

[5] array · 8 items

[0]

545323

[1]

Urate biosynthesis/inosine 5′-phosphate degradation

[2]

1.05E − 01

[3]

2.53E − 01

[4]

8.24E − 01

[5]

1.00E + 00

[6]

[7]

NT5E

[6] array · 8 items

[0]

142383

[1]

Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde

[2]

1.21E − 01

[3]

2.53E − 01

[4]

8.24E − 01

[5]

1.00E + 00

[6]

[7]

IDO1

[7] array · 8 items

[0]

KEGG

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8] array · 8 items

[0]

83051

[1]

Cytokine-cytokine receptor interaction

[2]

3.05E − 61

[3]

5.54E − 59

[4]

3.21E − 58

[5]

5.54E − 59

[6]

[7]

IL10, IL10RA, IL12A, IL12B, IL13, IL13RA1, TNFRSF9, IL17A, PDGFB, TNFSF12, IL17B, TNFRSF14, TNFRSF10C, CCL26,IL17F, TNFRSF4, IL22RA2, IL21, CCL7, CCR6, CCL11, CCL13, CCR8, CCL15, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, KIT, CX3CL1, CXCL12, IL19, CCR10, XCR1, CXCL13, PPBP, IL23A, IFNA2, IFNAR1, IFNB1, IFNG, TGFBR1, LIF, CSF1R, CSF2, CSF2RB, CSF3R, IL20, IL22,, CD40, TNFRSF13C, LTA, IL1RAP, IL2, IL3, IL4, IL4R, IL5, IL6, IL6R, IL7, IL26, CXCR1, IL9, CXCR2

[9] array · 8 items

[0]

83078

[1]

Hematopoietic cell lineage

[2]

4.22E − 35

[3]

3.84E − 33

[4]

2.22E − 32

[5]

7.67E − 33

[6]

[7]

HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, CD55, MME, KIT, CR2, TFRC, CD1A, CD3E, CSF1R, CSF2, CD8A, CD9, CSF3R, CD19, MS4A1, CD22, CD34, CD44, CD59, IL3, IL4, IL4R, IL5, IL6, IL6R, IL7

[10] array · 8 items

[0]

842771

[1]

Inflammatory bowel disease (IBD)

[2]

4.58E − 32

[3]

2.78E − 30

[4]

1.61E − 29

[5]

8.34E − 30

[6]

[7]

IL10, IL12A, IL12B, IL13, IL17A, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, GATA3, IL17F, STAT6, IL21, RELA, IL23A, IFNG, IL22, RORC, IL2, IL4, IL4R, IL5, IL6

[11] array · 8 items

[0]

83077

[1]

Jak-STAT signaling pathway

[2]

4.56E − 26

[3]

1.19E − 24

[4]

6.86E − 24

[5]

8.30E − 24

[6]

[7]

IL10, IL10RA, IL12A, IL12B, IL13, IL13RA1, BCL2, STAT5A, STAT6, PTPN6, IL22RA2, IL21, IL19, IL23A, IFNA2, IFNAR1, IFNB1, IFNG, LIF, CSF2, CSF2RB, CSF3R, IL20, IL22, IL2, IL3, IL4, IL4R, IL5, IL6, IL6R, IL7, IL9

[12] array · 8 items

[0]

213780

[1]

Tuberculosis

[2]

3.41E − 25

[3]

6.89E − 24

[4]

3.99E − 23

[5]

6.20E − 23

[6]

[7]

IL10, IL10RA, IL12A, IL12B, CEBPB, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, BCL2, CD209, BID, FCGR2A, FCGR2B, CARD9, NOS2, CASP3, RELA, TLR9, IL23A, IFNA2, IFNB1, IFNG, TIRAP, IRAK4, CD74, MAPK11, CTSS, IL6

[13] array · 8 items

[0]

83120

[1]

Asthma

[2]

4.56E − 24

[3]

8.30E − 23

[4]

4.80E − 22

[5]

8.30E − 22

[6]

[7]

IL10, IL13, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, FCER1A, CCL11, CD40, IL3, IL4, IL5, IL9

[14] array · 8 items

[0]

125138

[1]

Viral myocarditis

[2]

2.26E − 16

[3]

2.06E − 15

[4]

1.19E − 14

[5]

4.12E − 14

[6]

[7]

HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, CD55, BID, CASP3, CD80, CD86, CD40

[15] array · 8 items

[0]

373901

[1]

HTLV-I infection

[2]

2.85E − 15

[3]

2.35E − 14

[4]

1.36E − 13

[5]

5.18E − 13

[6]

[7]

HLA-B, PDGFB, HLA-C, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, ETS1, STAT5A, VCAM1, RELA, RELB, LCK, SLC2A1, TGFBR1, CD3E, CSF2, EGR1, EGR2, CD40, TNFRSF13C, LTA, IL2, IL6

[16] array · 8 items

[0]

213306

[1]

Measles

[2]

4.04E − 12

[3]

2.53E − 11

[4]

1.47E − 10

[5]

7.35E − 10

[6]

[7]

IL12A, IL12B, IL13, CD46, TNFRSF10C, CD209, STAT5A, FCGR2B, RELA, TLR9, IFNA2, IFNAR1, IFNB1, IFNG, CD3E, IRAK4, IL2, IL4, IL6

[17] array · 8 items

[0]

83074

[1]

Antigen processing and presentation

[2]

7.12E − 12

[3]

4.32E − 11

[4]

2.50E − 10

[5]

1.30E − 09

[6]

[7]

HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, IFNG, CD8A, CD74, CTSS

[18] array · 8 items

[0]

217173

[1]

Influenza A

[2]

4.98E − 11

[3]

2.75E − 10

[4]

1.59E − 09

[5]

9.07E − 09

[6]

[7]

IL12A, IL12B, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1,HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, TNFRSF10C, RELA, IFNA2, IFNAR1, IFNB1, IFNG, IRAK4, MAPK11, IL6

[19] array · 8 items

[0]

Pathway interaction database

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[20] array · 8 items

[0]

137933

[1]

IL4-mediated signaling events

[2]

7.74E − 16

[3]

8.36E − 14

[4]

4.40E − 13

[5]

8.36E − 14

[6]

[7]

IL10, IL13RA1, CEBPB, AICDA, ETS1, CCL26, STAT5A, STAT6, PTPN6, PIGR, CCL11, THY1, EGR2, LTA, IL4, IL4R, IL5

[21] array · 8 items

[0]

137922

[1]

IL12-mediated signaling events

[2]

9.23E − 15

[3]

4.99E − 13

[4]

2.62E − 12

[5]

9.97E − 13

[6]

[7]

IL12A, IL12B, HLA-DRA, HLA-DRB1, STAT5A, STAT6, EOMES, NOS2, RELA, RELB, LCK, IFNG, CD3E, CD8A, IL2, IL4

[22] array · 8 items

[0]

138000

[1]

IL23-mediated signaling events

[2]

1.32E − 12

[3]

4.75E − 11

[4]

2.50E − 10

[5]

1.42E − 10

[6]

[7]

IL12B, IL17A, IL17F, STAT5A, NOS2, IL19, RELA, IL23A, IFNG, CD3E, IL2, IL6

[23] array · 8 items

[0]

137929

[1]

IL27-mediated signaling events

[2]

1.43E − 11

[3]

3.87E − 10

[4]

2.04E − 09

[5]

1.55E − 09

[6]

[7]

IL12A, IL12B, IL17A, GATA3, STAT5A, IFNG, EBI3, IL2, IL6, IL27

[24] array · 8 items

[0]

138058

[1]

BCR signaling pathway

[2]

3.00E − 07

[3]

4.05E − 06

[4]

2.13E − 05

[5]

3.24E − 05

[6]

[7]

ETS1, PTPN6, FCGR2B, BTK, POU2F2, RELA, CD19, CD22, CD79A, CD79B

[25] array · 8 items

[0]

138055

[1]

TCR signaling in naive CD8 + T cells

[2]

2.28E − 04

[3]

1.30E − 03

[4]

6.82E − 03

[5]

2.46E − 02

[6]

[7]

PTPN6, LCK, CD3E, CD8A, CD80, CD86

[26] array · 8 items

[0]

137939

[1]

Direct p53 effectors

[2]

2.95E − 03

[3]

1.33E − 02

[4]

7.00E − 02

[5]

3.18E − 01

[6]

[7]

SPP1, BCL2, TNFRSF10C, BID, CD82, MAP4K4, CX3CL1, LIF

[27] array · 8 items

[0]

138081

[1]

FAS (CD95) signaling pathway

[2]

3.67E − 03

[3]

1.42E − 02

[4]

7.46E − 02

[5]

3.97E − 01

[6]

[7]

BID, BTK, CASP3, MAPK11

[28] array · 8 items

[0]

137995

[1]

HIV-1 Nef: Negative effector of Fas and TNF-alpha

[2]

3.67E − 03

[3]

1.42E − 02

[4]

7.46E − 02

[5]

3.97E − 01

[6]

[7]

BCL2, BID, CASP3, RELA

[29] array · 8 items

[0]

137944

[1]

IL1-mediated signaling events

[2]

2.58E − 02

[3]

6.45E − 02

[4]

3.40E − 01

[5]

1.00E + 00

[6]

[7]

TOLLIP, RELA, IRAK4

[30] array · 8 items

[0]

REACTOME

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[31] array · 8 items

[0]

1269310

[1]

Cytokine Signaling in Immune system

[2]

3.81E − 46

[3]

2.02E − 43

[4]

1.39E − 42

[5]

2.02E − 43

[6]

[7]

IL10, IL10RA, IL12A, IL12B, IL13, IL13RA1, IL16, TRAF3, TNFRSF9, IL17A, HLA-B, PDGFB, HLA-C, TNFSF12, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, TNFRSF14, GATA3, PSMB10, BCL2, PTAFR, IL1RL2, IL17F, PTK2, STAT5A, STAT6, TNFRSF4, PTPN6, IL22RA2, TOLLIP, CCL11, CCL19, CCL20, CCL22, KIT, NOS2, VCAM1, IL19, RAG1, RAG2, ZEB1, FN1, DUSP4, IRF8, CASP3, RELA, RELB, LCK, IL23A, S1PR1, IFNA2, IFNAR1, IFNB1, IFNG, LIF, CSF1R, CSF2, CSF2RB, CSF3R, EBI3, EGR1, IL20, CD80, CD86, IL22, CD40, IRAK4, CD44, TNFRSF13C, LTA, RORC, IL1RAP, IL2, IL3, IL4, IL4R, IL5, IL6, IL6R, IL7, IL27, IL9

[32] array · 8 items

[0]

1269318

[1]

Signaling by Interleukins

[2]

2.98E − 33

[3]

7.91E − 31

[4]

5.42E − 30

[5]

1.58E − 30

[6]

[7]

IL10, IL10RA, IL12A, IL12B, IL13, IL13RA1, IL16, IL17A, PDGFB, GATA3, PSMB10, BCL2, PTAFR, IL1RL2, IL17F, PTK2, STAT5A, STAT6, PTPN6, IL22RA2, TOLLIP, CCL11, CCL19, CCL20, CCL22, KIT,NOS2, VCAM1, IL19, RAG1, RAG2, ZEB1, FN1, DUSP4, CASP3, RELA, LCK, IL23A, S1PR1, LIF, CSF1R, CSF2, CSF2RB, CSF3R, EBI3, IL20, CD80, CD86, IL22, IRAK4, RORC, IL1RAP, IL2, IL3, IL4, IL4R, IL5, IL6, IL6R,IL7, IL27, IL9

[33] array · 8 items

[0]

1269203

[1]

Innate Immune System

[2]

4.93E − 25

[3]

8.72E − 23

[4]

5.98E − 22

[5]

2.62E − 22

[6]

[7]

MASP1, TRAF3, HLA-B, PDGFB, HLA-C, MAPKAPK2, CTSC, PECAM1, MBL2, PSMB10, CD55, CD46, BCL2, DEFB103B, PTAFR, CD209, PTK2, STAT6, DEFB1, DEFB4A, CFD, PTPN6, FCAR, FCER1A, PIGR, FCGR2A, CARD9, BTK, MIF, PLA2G2A, TOLLIP, C1R, C1S, C4A, PLAU, C4BPA, CCR6, MME, C6, C7, C8A, C8B, C9, KIT, NOS2, GPI, LILRA3, VTN, CLEC6A, FN1, ATG7, ITLN1, DUSP4, ICAM2, ICAM3, RELA, RELB, TLR9, LCK, PPBP, CFI, IFNA2, LGALS3, IFNB1, CSF2, CSF2RB, CD19, SIGIRR, CD80, CD86, TIRAP, IRAK4, CD44, CD59, MAPK11, IL2, IL3, IL5, CTSS, CXCR1, MASP2, CXCR2

[34] array · 8 items

[0]

1269171

[1]

Adaptive Immune System

[2]

1.51E − 15

[3]

1.15E − 13

[4]

7.86E − 13

[5]

8.03E − 13

[6]

[7]

HLA-B, PDGFB, HLA-C, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, CTSC, HLA-DRB1, TNFRSF14, PSMB10, PTPN22, CD209, PTPN6, SLAMF6, FCGR2B, BTK, KIT, KLRB1, LILRB5, VCAM1, ICOSLG, LILRA1, LILRA3, LILRA2, ATG7, ICAM2, ICAM3, ICAM4, RELA, BTLA, LCK, CD1A, CD3E, CD8A, CD19, CD22, CD80, CD86, ICAM5, TIRAP, CD34, CD40, CD74, CD79A, CD79B, CTLA4, CTSS

[35] array · 8 items

[0]

1269201

[1]

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

[2]

5.01E − 14

[3]

2.66E − 12

[4]

1.82E − 11

[5]

2.66E − 11

[6]

[7]

HLA-B, HLA-C, SLAMF6, FCGR2B, KLRB1, LILRB5, VCAM1, LILRA1, LILRA3, LILRA2, ICAM2, ICAM3, ICAM4, CD1A, CD3E, CD8A, CD19, CD22, ICAM5, CD34, CD40

[36] array · 8 items

[0]

1269546

[1]

Peptide ligand-binding receptors

[2]

6.17E − 08

[3]

1.82E − 06

[4]

1.25E − 05

[5]

3.27E − 05

[6]

[7]

CCR6, CCL13, CCR8, CCL16, CCL19, CCL20, CXCL11, XCL1, CX3CL1, CXCL12, CCR10, XCR1, CXCL13, PPBP, EDNRB, CXCR1, CXCR2

[37] array · 8 items

[0]

1269545

[1]

Class A/1 (Rhodopsin-like receptors)

[2]

4.71E − 07

[3]

1.14E − 05

[4]

7.79E − 05

[5]

2.50E − 04

[6]

[7]

PTAFR, PTGER4, CCR6, CCL13,CCR8,CCL16, CCL19, CCL20, CXCL11, XCL1, CX3CL1, CXCL12, CCR10, XCR1, CXCL13, GPR183, PPBP, S1PR1, EDNRB, CXCR1, CXCR2

[38] array · 8 items

[0]

1269340

[1]

Hemostasis

[2]

1.15E − 04

[3]

1.47E − 03

[4]

1.01E − 02

[5]

6.09E − 02

[6]

[7]

CD244, PDGFB, PECAM1, GATA3, PTK2, CFD, PTPN6, MIF, PLAU, NOS2, SELE, SELPLG, FN1, LCK, PPBP, IFNA2, IFNB1, CSF2, CSF2RB, CD9, CD44, CD48, CD74, IL2, IL3, IL5

[39] array · 8 items

[0]

1269501

[1]

MAPK family signaling cascades

[2]

3.27E − 04

[3]

3.40E − 03

[4]

2.33E − 02

[5]

1.74E − 01

[6]

[7]

PDGFB, PSMB10, PTK2, KIT, RAG1, RAG2, FN1, DUSP4, CSF2, CSF2RB, IL2, IL3, IL5, IL6, IL6R

[40] array · 8 items

[0]

1269240

[1]

Toll Like Receptor TLR6:TLR2 Cascade

[2]

3.46E − 04

[3]

3.40E − 03

[4]

2.33E − 02

[5]

1.84E − 01

[6]

[7]

MAPKAPK2, BTK, DUSP4, RELA, SIGIRR, TIRAP, IRAK4, MAPK11

[41] array · 8 items

[0]

Gen MAPP

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[42] array · 8 items

[0]

MAP00400

[1]

Phenylalanine tyrosine and tryptophan biosynthesis

[2]

1.38E − 01

[3]

5.02E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

BID

[43] array · 8 items

[0]

MAP_kinase_activity

[1]

MAP kinase activity

[2]

1.38E − 01

[3]

5.02E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

MAPK11

[44] array · 8 items

[0]

MAP00010

[1]

Glycolysis Gluconeogenesis

[2]

2.47E − 01

[3]

5.02E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

BID, GPI

[45] array · 8 items

[0]

MAP00030

[1]

Pentose phosphate

[2]

2.70E − 01

[3]

5.02E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

GPI

[46] array · 8 items

[0]

MAP00590

[1]

Prostaglandin and leukotriene metabolism

[2]

2.96E − 01

[3]

5.02E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

PLA2G2A

[47] array · 8 items

[0]

MAP00500

[1]

Starch and sucrose metabolism

[2]

3.34E − 01

[3]

5.02E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

GPI

[48] array · 8 items

[0]

MAP00330

[1]

Arginine and proline metabolism

[2]

5.05E − 01

[3]

5.81E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

NOS2

[49] array · 8 items

[0]

MAP00380

[1]

Tryptophan metabolism

[2]

5.73E − 01

[3]

5.81E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

IDO1

[50] array · 8 items

[0]

MAP00561

[1]

Glycerolipid metabolism

[2]

5.81E − 01

[3]

5.81E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

PLA2G2A

[51] array · 8 items

[0]

MSigDB C2 BIOCARTA (v6.0)

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[52] array · 8 items

[0]

M5883

[1]

Genes encoding secreted soluble factors

[2]

4.86E − 27

[3]

7.82E − 25

[4]

4.43E − 24

[5]

7.82E − 25

[6]

[7]

IL10, IL12A, IL12B, IL13, IL16, IL17A, PDGFB, TNFSF12, IL17B, CCL26, IL17F, CCL7, CCL11, CCL13, CCL15, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, CX3CL1, CXCL12, IL19, CXCL13, PPBP, IL23A, IFNA2, IFNB1, IFNG, LIF, CSF2, EBI3, IL20, IL22, LTA, IL2, IL3, IL4, IL5, IL6, IL7, IL26, IL9

[53] array · 8 items

[0]

M17406

[1]

Cytokine Network

[2]

2.71E − 22

[3]

2.18E − 20

[4]

1.24E − 19

[5]

4.36E − 20

[6]

[7]

IL10, IL12A, IL12B, IL13, IL16, IL17A, IFNB1, IFNG, LTA, IL2, IL3, IL4, IL5, IL6, IL9

[54] array · 8 items

[0]

M6910

[1]

Cytokines and Inflammatory Response

[2]

5.19E − 21

[3]

2.78E − 19

[4]

1.58E − 18

[5]

8.35E − 19

[6]

[7]

IL10, IL12A, IL12B, IL13, HLA-DRA, HLA-DRB1, IFNB1, IFNG, CSF2, LTA, IL2, IL3, IL4, IL5, IL6, IL7

[55] array · 8 items

[0]

M5885

[1]

Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors

[2]

7.80E − 21

[3]

3.14E − 19

[4]

1.78E − 18

[5]

1.26E − 18

[6]

[7]

IL10, IL12A, IL12B, IL13, MASP1, IL16, IL17A, PDGFB, TNFSF12, CTSC, IL17B, MBL2, CCL26, IL17F, CD209, PLAU, CCL7, CCL11, CCL13, CCL15, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, CX3CL1, CXCL12, IL19, CLEC6A, ITLN1, CXCL13, ITLN2, PPBP, IL23A, IFNA2, LGALS3, IFNB1, IFNG, LIF, CSF2, EBI3, IL20, IL22, LTA, IL2, IL3, IL4, IL5, CTSS, IL6, IL7, IL26, IL9, MASP2

[56] array · 8 items

[0]

M5889

[1]

Ensemble of genes encoding extracellular matrix and extracellular matrix-associated proteins

[2]

4.62E − 17

[3]

1.49E − 15

[4]

8.43E − 15

[5]

7.44E − 15

[6]

[7]

IL10, IL12A, IL12B, IL13, MASP1, IL16, IL17A, PDGFB, TNFSF12, SPP1, CTSC,IL17B, MBL2, CCL26, IL17F, CD209, PLAU, CCL7,CCL11, CCL13, CCL15,CCL16, CCL18, CCL19, CCL20,CCL22, CCL24, CXCL11,XCL1, CX3CL1, CXCL12, IL19, VTN,CLEC6A, FN1, ITLN1, CXCL13,ITLN2, PPBP, IL23A,IFNA2, LGALS3, IFNB1, IFNG, TGFBI, LIF, CSF2, EBI3, IL20, IL22, LTA, IL2, IL3, IL4, IL5, CTSS, IL6, IL7, IL26, IL9, MASP2

[57] array · 8 items

[0]

M1467

[1]

The Co-Stimulatory Signal During T-cell Activation

[2]

4.81E − 11

[3]

7.03E − 10

[4]

3.98E − 09

[5]

7.74E − 09

[6]

[7]

HLA-DRA, HLA-DRB1, ICOSLG, LCK, CD3E, CD80, CD86, CTLA4, IL2

[58] array · 8 items

[0]

M3952

[1]

Cells and Molecules involved in local acute inflammatory response

[2]

1.02E − 05

[3]

7.46E − 05

[4]

4.22E − 04

[5]

1.64E − 03

[6]

[7]

C6, C7, VCAM1, SELPLG,IL6

[59] array · 8 items

[0]

M18215

[1]

Role of Tob in T-cell activation

[2]

3.16E − 05

[3]

2.21E − 04

[4]

1.25E − 03

[5]

5.08E − 03

[6]

[7]

IFNG, TGFBR1, CD3E, IL2, IL4

[60] array · 8 items

[0]

M13968

[1]

HIV-I Nef: negative effector of Fas and TNF

[2]

6.46E − 04

[3]

3.15E − 03

[4]

1.78E − 02

[5]

1.04E − 01

[6]

[7]

BCL2,PTK2, BID, CASP3, RELA, ARHGDIB

[61] array · 8 items

[0]

M13247

[1]

T Cytotoxic Cell Surface Molecules

[2]

1.90E − 03

[3]

6.80E − 03

[4]

3.85E − 02

[5]

3.06E − 01

[6]

[7]

CD3E, CD8A, THY1

[62] array · 8 items

[0]

Panther DB

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[63] array · 8 items

[0]

P00036

[1]

Interleukin signaling pathway

[2]

6.51E − 19

[3]

2.47E − 17

[4]

1.05E − 16

[5]

2.47E − 17

[6]

[7]

IL10,IL10RA, IL12A,IL13, IL13RA1, IL17A, MAPKAPK2, IL17F, STAT5A, STAT6, IL21, IL23A, IL2, IL4, IL4R, IL5, IL6, IL6R, IL7, CXCR1, IL9, CXCR2

[64] array · 8 items

[0]

P00031

[1]

Inflammation mediated by chemokine and cytokine signaling pathway

[2]

4.36E − 07

[3]

8.28E − 06

[4]

3.50E − 05

[5]

1.66E − 05

[6]

[7]

CCL26, CCL7, CCR6, CCL11, CCL13, CCR8, CCL18, CCL20, CCL22, CX3CL1, CCR10, XCR1, IFNAR1, IFNG, CXCR1, CXCR2

[65] array · 8 items

[0]

P00053

[1]

T cell activation

[2]

7.23E − 05

[3]

8.13E − 04

[4]

3.44E − 03

[5]

2.75E − 03

[6]

[7]

HLA-DPA1, HLA-DQA1, HLA-DRA, LCK, CD3E, CD80, CD86, CD74

[66] array · 8 items

[0]

P00010

[1]

B cell activation

[2]

8.56E − 05

[3]

8.13E − 04

[4]

3.44E − 03

[5]

3.25E − 03

[6]

[7]

PTPN6, BTK, CD19, CD22, CD79A, CD79B, MAPK11

[67] array · 8 items

[0]

P00054

[1]

Toll receptor signaling pathway

[2]

2.14E − 03

[3]

1.62E − 02

[4]

6.86E − 02

[5]

8.12E − 02

[6]

[7]

TOLLIP, RELA, TLR9, IFNB1, IRAK4

[68] array · 8 items

[0]

P00006

[1]

Apoptosis signaling pathway

[2]

2.67E − 03

[3]

1.69E − 02

[4]

7.14E − 02

[5]

1.01E − 01

[6]

[7]

BCL2, BID, BCL2L11, CASP3, RELA, RELB, LTA

[69] array · 8 items

[0]

P00035

[1]

Interferon-gamma signalingpathway

[2]

1.42E − 02

[3]

7.69E − 02

[4]

3.25E − 01

[5]

5.39E − 01

[6]

[7]

PTPN6, IFNG, MAPK11

[70] array · 8 items

[0]

P00046

[1]

Oxidative stress response

[2]

5.17E − 02

[3]

1.86E − 01

[4]

7.88E − 01

[5]

1.00E + 00

[6]

[7]

BCL2, DUSP4, MAPK11

[71] array · 8 items

[0]

P00047

[1]

PDGF signaling pathway

[2]

8.39E − 02

[3]

2.44E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

PDGFB, MAPKAPK2, ETS1, STAT5A, STAT6

[72] array · 8 items

[0]

P00034

[1]

Integrin signalling pathway

[2]

5.94E − 01

[3]

7.28E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

ITGAE, PTK2, FN1

[73] array · 8 items

[0]

Pathway Ontology

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[74] array · 8 items

[0]

PW:0000104

[1]

intrinsic apoptotic

[2]

1.82E − 03

[3]

7.63E − 02

[4]

3.30E − 01

[5]

7.63E − 02

[6]

[7]

BCL2, BID, BCL2L11, CASP3

[75] array · 8 items

[0]

PW:0000515

[1]

Interleukin-10 signaling

[2]

7.84E − 01

[3]

1.57E − 01

[4]

6.78E − 01

[5]

6.78E − 01

[6]

[7]

IL10

[76] array · 8 items

[0]

PW:0000516

[1]

Interleukin-6 signaling

[2]

7.84E − 01

[3]

1.57E − 01

[4]

6.78E − 01

[5]

6.78E − 01

[6]

[7]

IL6

[77] array · 8 items

[0]

PW:0000499

[1]

Nuclear Factor Kappa B signaling

[2]

9.58E − 01

[3]

1.60E − 01

[4]

6.91E − 01

[5]

6.91E − 01

[6]

[7]

RELA, RELB

[78] array · 8 items

[0]

PW:0000009

[1]

programmed cell death

[2]

1.00E + 00

[3]

1.80E − 01

[4]

7.78E − 01

[5]

7.78E − 01

[6]

[7]

BCL2, CASP3

[79] array · 8 items

[0]

PW:0000102

[1]

The extracellular signal-regulated RAF/MEK/ERK signaling

[2]

8.14E − 02

[3]

2.18E − 01

[4]

9.44E − 01

[5]

1.00E + 00

[6]

[7]

SPP1, S1PR1

[80] array · 8 items

[0]

PW:0000529

[1]

angiotensin (1-7) signaling

[2]

8.83E − 02

[3]

2.18E − 01

[4]

9.44E − 01

[5]

1.00E + 00

[6]

[7]

MME

[81] array · 8 items

[0]

PW:0000106

[1]

extrinsic apoptotic

[2]

1.05E − 01

[3]

2.45E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

CASP3

[82] array · 8 items

[0]

PW:0000559

[1]

hexosamine biosynthetic

[2]

1.21E − 01

[3]

2.55E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

GPI

[83] array · 8 items

[0]

PW:0000228

[1]

G protein signaling via Galphai family

[2]

1.53E − 01

[3]

2.80E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

S1PR1

[84] array · 8 items

[0]

SMPDB

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[85] array · 8 items

[0]

SMP00094

[1]

Sulindac Pathway

[2]

1.21E − 01

[3]

4.52E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

PLA2G2A

[86] array · 8 items

[0]

SMP00040

[1]

Glycolysis

[2]

2.14E − 01

[3]

4.52E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

GPI

[87] array · 8 items

[0]

SMP00063

[1]

Tryptophan Metabolism

[2]

2.70E − 01

[3]

4.52E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

IDO1

[88] array · 8 items

[0]

SMP00379

[1]

NifedipinePathway

[2]

2.83E − 01

[3]

4.52E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

EDNRB

[89] array · 8 items

[0]

SMP00006

[1]

Tyrosine Metabolism

[2]

3.59E − 01

[3]

4.84E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

MIF

[90] array · 8 items

[0]

SMP00320

[1]

Intracellular Signalling Through Adenosine Receptor A2a and Adenosine

[2]

4.57E − 01

[3]

4.84E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

MAPK11

row_count

column_count

numeric_cells

544

header_rows

locator

section[13]/table-wrap[2]#Tab3

[5] object · 16 fields

asset:table:pmid:33251083:4

role

table

format

jats-table

media_type

application/vnd.jats.table+json

uri

null

sha256

sha256:3d0cc2025b76ce360a2ebcd6f7a40ea02ca2add666d309680d150a2f033eabd0

bytes

8645

access

open

state

verified

reader

read_table

reader_status

available

identifier

section[14]/table-wrap[1]#Tab4

version

null

note

The enriched GO terms of the up regulated differentially expressed genes

structure object · 5 fields

pmcid

PMC7679428

section_index

section_title

Gene ontology (GO) enrichment analysis for DEGs

row_count

column_count

table object · 8 fields

label

Table 4

caption

The enriched GO terms of the up regulated differentially expressed genes

rows array · 31 items

[0] array · 9 items

[0]

GO ID

[1]

Category

[2]

GO Name

[3]

P Value

[4]

FDR B&H

[5]

FDR B&Y

[6]

Bonferroni

[7]

Gene Count

[8]

Gene

[1] array · 9 items

[0]

GO:0002682

[1]

[2]

Regulation of immune system process

[3]

1.87E − 103

[4]

9.66E − 100

[5]

8.82E − 99

[6]

9.66E − 100

[7]

153

[8]

IL10, IL12A, IL12B, IL13, IRGM, MASP1, TRAF3, IL17A, CEBPB, CD244, HLA-B, HLA-C, IDO1, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, MAPKAPK2, HLA-DQB1, HLA-DRA, CTSC, HLA-DRB1, PECAM1, MBL2, TNFRSF14, GATA3, ETS1, PSMB10, CD55, PTPN22, CD46, BCL2, PTAFR, CD83, PTGER4, IL1RL2, CD209, PTK2, STAT5A, STAT6, TNFRSF4, CFD, PTPN6, SLAMF6, FCER1A, PIGR, FCGR2A, FCGR2B, CARD9, BTK, MIF, IL21, C1R, C1S, C4A, C4BPA, CCL7, CCR6, C6, C7, C8A, CCL19, C8B, CCL20, C9, CCL24, TAL1, XCL1, KIT, CX3CL1, KLRB1, CXCL12, VCAM1, SELE, GPI, RAG1, DPP4, ICOSLG, LILRA1, LILRA2, ZEB1, VTN, CLEC6A, ATG7, ICAM2, ICAM3, ICAM4, CXCL13, CASP3, AIRE, RELA, BTLA, RELB, GPR183, TLR9, LCK, CFI, CR2, IL23A, IFNA2, LGALS3, TFRC,IFNB1, IFNG, LIF, CD1A, CD3E, CSF1R, CSF2, CD8A, THY1, CD9, CSF3R, CD19, TIGIT, MS4A1, EBI3, CD22, IL20, CD80, CD86, ICAM5, TIRAP, CD34, CD40, IRAK4, CD44, CD48, TNFRSF13C, CD59, CD74, CD79A, CD79B, LTA, RORC, CTLA4, PAX5, HAMP, MAPK11, IL2, IL3, IL4, IL4R, IL5, CTSS, IL6, IL6R, IL7, IL27, MASP2, CXCR2

[2] array · 9 items

[0]

GO:0019221

[1]

[2]

Cytokine-mediated signaling pathway

[3]

1.05E − 84

[4]

1.35E − 81

[5]

1.23E − 80

[6]

5.40E − 81

[7]

131

[8]

IL10, IL10RA, IL12A, IL12B, IL13, IRGM, MASP1, TRAF3, IL17A, ILF3, CEBPB, CD244, HLA-B, AICDA, HLA-C, IDO1, TAGAP, HLA-DPA1, HLA-DPB1, HLA-DQA1, MAPKAPK2, HLA-DQB1, HLA-DRA, HLA-DRB1, MBL2, TNFRSF14, GATA3, PSMB10, CD55, PTPN22, CD46, BCL2, DEFB103B, PTAFR, PTGER4, IL1RL2, CCL26, CD209, STAT5A, BID, DEFB1, DEFB4A, CFD, PTPN6, SLAMF6, FCGR2B, CARD9, BTK, KLRF2, MIF, IL21, PLA2G2A, TOLLIP, C1R, C1S, C4A, C4BPA, CCL7, CCL11, CCL13, BATF3, CCL15, CCL16, C6, C7, CCL18, C8A, CCL19, C8B, CCL20, CCL22, C9, CCL24, CXCL11, XCL1, CX3CL1, NOS2, CXCL12, VCAM1, SELE, RAG2, LILRA2, CLEC6A, BCL2L11, ATG7, ITLN1, ICAM2, ICAM3, IRF8, CXCL13, CASP3, RELA, RELB, TLR9, PPBP, CFI, CR2, IL23A, IFNA2, EDNRB, LGALS3, IFNAR1, IFNB1, IFNG, CSF1R, CSF2, CD8A, CSF2RB, MS4A1, EGR1, SIGIRR, CD80, CD86, TIRAP, CD40, IRAK4, CD44, CD74, CD79B, LTA, HAMP, MAPK11, IL1RAP, IL2, IL4, IL4R, CTSS, IL6, IL6R, IL27, MASP2

[3] array · 9 items

[0]

GO:0009607

[1]

[2]

RESPONSE to biotic stimulus

[3]

7.42E − 81

[4]

7.65E − 78

[5]

6.99E − 77

[6]

3.83E − 77

[7]

120

[8]

IL10, IL10RA, IL12A, IL12B, IL13, IL13RA1, IRGM, IL16, TRAF3, TNFRSF9, IL17A, CEBPB, HLA-B, PDGFB, HLA-C, TNFSF12, SPP1, HLA-DPA1, HLA-DPB1, HLA-DQA1, MAPKAPK2, HLA-DQB1, HLA-DRA, HLA-DRB1, TNFRSF14, GATA3, ETS1, PSMB10, BCL2, PTAFR, IL1RL2, CCL26, IL17F,STAT5A, STAT6, TNFRSF4, PTPN6, IL22RA2, NFIL3, BTK, MIF, IL21, TOLLIP, CCL7, CCR6, CCL11, CCL13, CCR8, CCL15, MME, CCL16, CCL18, CCL19, CCL20, CCL22,CCL24, CXCL11, XCL1, KIT, CX3CL1, NOS2, CXCL12, VCAM1, IL19, SELE, SELPLG, CCR10, XCR1, TCF7, ZEB1, FN1, IRF8, CXCL13, CASP3, RELA, RELB, PPBP, IL23A, S1PR1, IFNA2, TFRC, IFNAR1, IFNB1, IFNG, LIF, CSF1R, CSF2, CSF2RB, CSF3R, EBI3, EGR1, SIGIRR, IL20, CD80, CD86, TIRAP, IL22, CD40, IRAK4, CD44, TNFRSF13C, CD74, LTA, RORC, HAMP, MAPK11, IL1RAP, IL2, IL3, IL4, IL4R, IL5, IL6, IL6R, IL7, IL26, IL27, CXCR1, IL9, CXCR2

[4] array · 9 items

[0]

GO:0009607

[1]

[2]

Response to biotic stimulus

[3]

7.42E − 81

[4]

7.65E − 78

[5]

6.99E − 77

[6]

3.83E − 77

[7]

131

[8]

[5] array · 9 items

[0]

GO:0034097

[1]

[2]

Response to cytokine

[3]

3.04E − 80

[4]

2.61E − 77

[5]

2.39E − 76

[6]

1.57E − 76

[7]

120

[8]

IL10, IL10RA, IL12A, IL12B, IL13, IL13RA1, IRGM, IL16, TRAF3, TNFRSF9, IL17A, CEBPB, HLA-B, PDGFB, HLA-C, TNFSF12, SPP1, HLA-DPA1, HLA-DPB1, HLA-DQA1, MAPKAPK2, HLA-DQB1, HLA-DRA, HLA-DRB1, TNFRSF14, GATA3, ETS1, PSMB10, BCL2, PTAFR, IL1RL2, CCL26, IL17F, STAT5A, STAT6, TNFRSF4, PTPN6, IL22RA2, NFIL3, BTK, MIF, IL21, TOLLIP, CCL7, CCR6, CCL11, CCL13, CCR8, CCL15, MME, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, KIT, CX3CL1, NOS2, CXCL12, VCAM1, IL19, SELE, SELPLG, CCR10, XCR1, TCF7, ZEB1, FN1, IRF8, CXCL13, CASP3, RELA, RELB, PPBP, IL23A, S1PR1, IFNA2, TFRC, IFNAR1, IFNB1, IFNG, LIF, CSF1R, CSF2, CSF2RB, CSF3R, EBI3, EGR1, SIGIRR, IL20, CD80, CD86, TIRAP, IL22, CD40, IRAK4, CD44, TNFRSF13C, CD74, LTA, RORC, HAMP, MAPK11, IL1RAP, IL2, IL3, IL4, IL4R, IL5, IL6, IL6R, IL7, IL26, IL27, CXCR1, IL9, CXCR2

[6] array · 9 items

[0]

GO:0042110

[1]

[2]

T cell activation

[3]

8.30E − 63

[4]

2.25E − 60

[5]

2.06E − 59

[6]

4.28E − 59

[7]

[8]

IL10, IL12A, IL12B, CEBPB, CD244, IDO1, HLA-DMA, HLA-DMB, HLA-DPA1, HLA-DPB1, HLA-DQA1, TNFRSF14, GATA3, PSMB10, CD55, PTPN22, CD46, BCL2, CD83, PTGER4, IL1RL2, CD209, STAT5A, STAT6, TNFRSF4, EOMES, PTPN6, SLAMF6, FCGR2B, IL21, CCR6, CCL19, CCL20, XCL1, KIT, CXCL12, VCAM1, RAG1, RAG2, DPP4, ICOSLG, TCF7, ZEB1, CASP3, AIRE, BTLA, RELB, GPR183, LCK, IL23A, IFNA2, LGALS3, TFRC, IFNAR1, IFNB1, IFNG, CD3E, CD8A, THY1, TIGIT, EBI3, EGR1, CD80, CD86, CD44, CD48, TNFRSF13C, CD74, RORC, CTLA4, IL2, IL4, IL4R, IL6, IL6R, IL7, IL27

[7] array · 9 items

[0]

GO:0001816

[1]

[2]

Cytokine production

[3]

8.07E − 58

[4]

1.81E − 55

[5]

1.65E − 54

[6]

4.16E − 54

[7]

[8]

IL10, IL12A, IL12B, IL13, TRAF3, TNFRSF9, IL17A, CEBPB, CD244, IDO1, HLA-DPA1, HLA-DPB1, MAPKAPK2, IL17B, MBP, TNFRSF14, GATA3, CD55, PTPN22, CD46, PTAFR, CD83, PTGER4, IL1RL2, IL17F, STAT5A, STAT6, TNFRSF4, EOMES, PTPN6, SLAMF6, FCER1A, FCGR2B, CARD9, BTK, KLRF2, MIF, IL21, CCL19, CCL20, XCL1, KIT, CX3CL1, NOS2, IL19, ICOSLG, LILRA2, CLEC6A, FN1, IRF8, AIRE, RELA, RELB, TLR9, IL23A, IFNA2, IFNAR1, IFNB1, IFNG, CD3E, CSF1R, CSF2, TIGIT, EBI3, EGR1,SIGIRR, CD80, CD86, TIRAP, CD34, CD40, IRAK4, TNFRSF13C, CD74,LTA, RORC, MAPK11, IL1RAP, IL2, IL4, IL4R, IL6, IL6R, IL7, IL26, IL27, IL9

[8] array · 9 items

[0]

GO:0002694

[1]

[2]

Regulation of leukocyte activation

[3]

7.07E − 57

[4]

1.52E − 54

[5]

1.39E − 53

[6]

3.65E − 53

[7]

[8]

IL10, IL12A, IL12B, IL13, CEBPB, CD244, IDO1, HLA-DMA, HLA-DMB, HLA-DPA1, HLA-DPB1, HLA-DQA1, CTSC, TNFRSF14, GATA3, CD55, PTPN22, CD46, BCL2, PTAFR, CD83, IL1RL2, CD209, STAT5A, STAT6, TNFRSF4, PTPN6, FCER1A, FCGR2B, BTK, MIF, IL21, CCR6, CCL19, CCL20, XCL1, CX3CL1, VCAM1, RAG1, DPP4, ICOSLG, ZEB1, CASP3, BTLA, GPR183, TLR9, LCK, IL23A, IFNA2, LGALS3, TFRC, IFNB1, IFNG, CD3E, THY1, CD19, TIGIT, EBI3, CD22, CD80, CD86, TIRAP, CD40, CD44, TNFRSF13C, CD74, RORC, CTLA4, HAMP, IL2, IL4, IL4R, IL5, IL6, IL6R, IL7, IL27

[9] array · 9 items

[0]

GO:0006954

[1]

[2]

Inflammatory response

[3]

5.64E − 55

[4]

1.12E − 52

[5]

1.02E − 51

[6]

2.91E − 51

[7]

[8]

IL10, IL12B, IL13, IRGM, IL17A, CEBPB, IDO1, SPP1, MAPKAPK2, CTSC, IL17B, MBL2, GATA3, ETS1, PTAFR, PLA2G2E, PTGER4, IL1RL2, CCL26, IL17F, STAT5A, TNFRSF4, IL22RA2, FCER1A, FCGR2B, BTK,MIF, IL21, PLA2G2A, TOLLIP, C4A, CCL7, CCR6,CCL11, CCL13, CCL15, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, KIT, CX3CL1, NOS2, VCAM1, SELE, XCR1, FN1, NT5E, CXCL13, RELA, RELB, TLR9, PPBP, IL23A, IFNA2, EDNRB, IFNG, CSF1R, SIGIRR, IL20, TIRAP, IL22, CD40, CD44, LTA, HAMP, IL1RAP, IL2, CDH5, IL4, IL4R, IL5, CTSS, IL6, IL6R, IL27, IL9, CXCR2

[10] array · 9 items

[0]

GO:0007155

[1]

[2]

Cell adhesion

[3]

3.87E − 42

[4]

3.50E − 40

[5]

3.20E − 39

[6]

2.00E − 38

[7]

[8]

IL10, IL12A, IL12B, CEBPB,CD244, IDO1, HLA-DMA, HLA-DMB, SPP1, HLA-DPA1, HLA-DPB1, HLA-DQA1, PECAM1, MBP, TNFRSF14, GATA3, ETS1, CD55, PTPN22, CD46, BCL2, PTAFR, CD83, ITGAE, PTGER4, IL1RL2, CD209, PTK2, STAT5A, PTPN6, FCGR2B, IL21, PLAU, CCL11, CCR8, CCL19, XCL1, KIT, MAP4K4, CX3CL1, CXCL12, VCAM1, SELE, SELPLG, RAG1, DPP4, ICOSLG, VTN, FN1, BCL2L11, NT5E, ICAM2, ICAM3, ICAM4, CXCL13, CASP3, RELA, BTLA, LCK, IL23A, S1PR1, IFNA2, LGALS3, TFRC, IFNB1, IFNG, TGFBI, ARHGDIB, CD3E, THY1, CD9, CSF3R, TIGIT, EBI3, CD22, CD80, CD86, ICAM5, CD34, CD44, TNFRSF13C, CD74, CTLA4,IL1RAP, IL2, CDH5, IL4, IL4R, IL6, IL6R, IL7

[11] array · 9 items

[0]

GO:0009986

[1]

[2]

Cell surface

[3]

8.40E − 48

[4]

1.04E − 45

[5]

6.72E − 45

[6]

3.09E − 45

[7]

[8]

IL12A, IL12B, IL13, IL13RA1, TNFRSF9, IL17A, CD244, HLA-B, PDGFB, HLA-C, HLA-DMA, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DRA, HLA-DRB1, PECAM1, MBL2, MBP, TNFRSF14, CD55, CD46, TNFRSF10C, CD83, ITGAE, CD209, TNFRSF4, FCER1A, FCGR2B, FCGRT, MIF, PLAU, CCR6, CCR8, MME, KIT, CX3CL1, CXCL12, VCAM1, CCR10, DPP4, ICOSLG, XCR1, NT5E, BTLA, CR2, S1PR1, LGALS3, TFRC, IFNG, TGFBR1, CD1A, CD3E, CSF1R, CD8A, THY1, CD9, CSF3R, CD19, TIGIT, MS4A1, EBI3, CD22, CD80, CD86, CD34, CD40, CD44, CD48, TNFRSF13C, CD59, CD74, CD79A, CD79B, RORC, CTLA4, CDH5, IL4, CTSS, IL6, IL6R, CXCR1, CXCR2

[12] array · 9 items

[0]

GO:0097478

[1]

[2]

Leaflet of membrane bilayer

[3]

8.80E − 48

[4]

1.04E − 45

[5]

6.72E − 45

[6]

3.24E − 45

[7]

[8]

IL12B, IL13, IL13RA1, TRAF3, TNFRSF9, IL17A, CD244, HLA-B, HLA-C, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, PECAM1, TNFRSF14, PTPN22, CD83, ITGAE, CD209, TNFRSF4, FCER1A, FCGR2B, FCGRT, CCR6, CCR8, KIT, CXCL12, VCAM1, CCR10, ICOSLG, XCR1, BTLA, LCK, CR2, S1PR1, LGALS3, TFRC, IFNG, CD1A, CD3E, BCAP31, CD8A, THY1, CD9, CSF3R, CD19, MS4A1, EBI3, CD22, CD80, CD86, CD34,CD40, CD44, CD48, TNFRSF13C, CD59,CD74, CD79A, CD79B, RORC, CTLA4, CDH5, IL4, IL6, IL6R, CXCR1, CXCR2

[13] array · 9 items

[0]

GO:0031226

[1]

[2]

Intrinsic component of plasma membrane

[3]

4.10E − 24

[4]

3.01E − 22

[5]

1.96E − 21

[6]

1.51E − 21

[7]

[8]

IL13RA1, TRAF3, TNFRSF9,TNFSF12, HLA-DPA1, HLA-DQA1, HLA-DRA, CD46,PTAFR, CD83, ITGAE, IL1RL2, TNFRSF4, CD82, SLAMF6,FCAR, FCER1A, PIGR, FCGR2B, KLRF2, TOLLIP, CCR6, CCR8, MME, C6, C7, C8A, C8B, C9, KIT, VCAM1, SELE, SELPLG, CCR10, ICOSLG, XCR1, LILRA2, ICAM2, ICAM3, ICAM4, BTLA, GPR183, S1PR1, SLC2A1, EDNRB, TFRC, IFNAR1, TGFBR1,CD1A, CD3E, BCAP31, CSF1R, CD8A, THY1, CSF2RB, CD9, CSF3R, CD19, MS4A1, EBI3, CD22, ICAM5, CD34, CD40, CD44, CD48, CD59, CD74, CD79B, CTLA4, IL1RAP, IL4R, IL6, IL6R, CXCR2

[14] array · 9 items

[0]

GO:0098589

[1]

[2]

Membrane region

[3]

7.35E − 11

[4]

1.93E − 09

[5]

1.25E − 08

[6]

2.70E − 08

[7]

[8]

PECAM1, CD55, CD46, STAT6, FCER1A, BTK, MME, SELE, SELPLG, DPP4, ITLN1, CASP3, LCK, S1PR1, SLC2A1, EDNRB, TGFBR1, CD1A, CD8A, THY1, CD19, MS4A1, CD48, CD79A

[15] array · 9 items

[0]

GO:0043235

[1]

[2]

Receptor complex

[3]

3.10E − 10

[4]

6.71E − 09

[5]

4.35E − 08

[6]

1.14E − 07

[7]

[8]

IL12B, IL13RA1, TRAF3, ITGAE, PTPN6, PIGR, TOLLIP, KIT, ITLN1, CR2, TFRC, TGFBR1, CD3E, CSF1R, CD8A, CSF2RB, CSF3R, EBI3, CD40, CD44, CD74, CD79A, CD79B, IL4R, IL6, IL6R

[16] array · 9 items

[0]

GO:0030141

[1]

[2]

Secretory granule

[3]

3.67E − 07

[4]

5.20E − 06

[5]

3.37E − 05

[6]

1.35E − 04

[7]

[8]

PDGFB, CTSC, PECAM1, CD55, CD46, PTAFR, CFD, PTPN6, FCAR, PIGR, FCGR2A, MIF, PLA2G2A, TOLLIP, PLAU, MME, KIT, GPI, LILRA3, FN1, ATG7, PPBP, LGALS3, CD9, CD44, CD59, CTSS, CXCR1, CXCR2

[17] array · 9 items

[0]

GO:0005764

[1]

[2]

Lysosome

[3]

1.31E − 06

[4]

1.49E − 05

[5]

9.69E − 05

[6]

4.81E − 04

[7]

[8]

IL13, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, CTSC, HLA-DRB1, FCER1A, PIGR, BTK, TOLLIP,KIT, DPP4, TLR9, IFNAR1, CD34, CD74, IL4, IL4R, CTSS, CXCR2

[18] array · 9 items

[0]

GO:0005794

[1]

[2]

Golgi apparatus

[3]

4.18E − 03

[4]

2.00E − 02

[5]

1.30E − 01

[6]

1.00E + 00

[7]

[8]

IRGM, HLA-B, PDGFB, HLA-C,SPP1, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, CTSC, HLA-DRB1, CD55, CD46, DEFB103B, DEFB1,DEFB4A, MME, VCAM1, DPP4, VTN, TLR9, SLC2A1, TGFBI, BCAP31, CD44, CD59, CD74, CD79B, B3GAT1, CTLA4

[19] array · 9 items

[0]

GO:0048471

[1]

[2]

Perinuclear region of cytoplasm

[3]

2.87E − 02

[4]

8.46E − 02

[5]

5.49E − 01

[6]

1.00E + 00

[7]

[8]

TNFSF12, SPP1, PTPN22, BCL2, BTK, PLA2G2A, TOLLIP, CX3CL1, NOS2, SELE, ATG7,TFRC, TRAF4, BCAP31, CD34, CTLA4

[20] array · 9 items

[0]

GO:0044297

[1]

[2]

Cell body

[3]

9.03E − 02

[4]

2.08E − 01

[5]

1.00E + 00

[6]

1.00E + 00

[7]

[8]

PDGFB, MBP, PTGER4, FCGR2B, C4A, MME, CX3CL1, CASP3,IFNG, CD3E, THY1, CD22, CD40, IL6R

[21] array · 9 items

[0]

GO:0030054

[1]

[2]

Cell junction

[3]

9.70E − 02

[4]

2.20E − 01

[5]

1.00E + 00

[6]

1.00E + 00

[7]

[8]

PECAM1, CD46, PTK2, PTPN6, C4A, PLAU, MME, KIT, MAP4K4, DPP4, LCK, SLC2A1, TGFBR1, TRAF4, CD3E, THY1, CD9, CD44,CD59, HAMP, CDH5

[22] array · 9 items

[0]

GO:0005126

[1]

[2]

Cytokine receptor binding

[3]

8.37E − 54

[4]

6.01E − 51

[5]

4.30E − 50

[6]

6.01E − 51

[7]

[8]

IL10, IL12A, IL12B, IL13, TRAF3, TNFSF12, GATA3, DEFB103B, CCL26, IL17F, BID, DEFB1, DEFB4A, MIF, IL21, TOLLIP, CCL7, CCL11, CCL13, CCL15, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, CX3CL1, CXCL12, CXCL13, CASP3, TLR9, PPBP, IL23A, IFNA2, IFNB1, IFNG, TGFBR1, LIF, TRAF4, CSF2, EBI3, IL20, IL22,IRAK4, CD44, LTA, IL1RAP, IL2,IL3, CDH5,IL4, IL5, IL6, IL6R, IL7, IL27, IL9

[23] array · 9 items

[0]

GO:0005102

[1]

[2]

Signaling receptor binding

[3]

3.78E − 49

[4]

9.05E − 47

[5]

6.48E − 46

[6]

2.72E − 46

[7]

108

[8]

IL10, IL12A, IL12B, IL13, IL16, TRAF3, IL17A, CEBPB, CD244, HLA-B, PDGFB, HLA-C, TNFSF12, HLA-DOB, SPP1, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, IL17B, MBL2, GATA3, DEFB103B, CCL26, IL17F, PTK2, BID, DEFB1, DEFB4A, PTPN6, PIGR, MIF, IL21, TOLLIP, CCL7, CCL11, CCL13, CCL15, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, CX3CL1, CXCL12, VCAM1, IL19, SELPLG, GPI, DPP4, ICOSLG, VTN, FN1, ATG7, ICAM2, ICAM3, ICAM4, CXCL13, CASP3, TLR9, LCK, PPBP, IL23A, S1PR1, IFNA2, EDNRB, LGALS3, IFNB1, IFNG, TGFBI, TGFBR1, LIF, TRAF4, CD3E,BCAP31, CSF2, CD8A, THY1, CD9, TIGIT, MS4A1, EBI3, CD22, IL20, CD86, ICAM5, TIRAP, IL22, IRAK4, CD44, CD74, LTA, HAMP, IL1RAP, IL2, IL3, CDH5, IL4, IL5, IL6, IL6R, IL7, IL26, IL27, IL9

[24] array · 9 items

[0]

GO:0030545

[1]

[2]

Chemokine receptor binding

[3]

2.63E − 22

[4]

2.36E − 20

[5]

1.69E − 19

[6]

1.89E − 19

[7]

[8]

DEFB103B, CCL26, DEFB1, DEFB4A, CCL7, CCL11,CCL13, CCL15, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, CX3CL1, CXCL12, CXCL13, PPBP

[25] array · 9 items

[0]

GO:0098772

[1]

[2]

Molecular function regulator

[3]

1.42E − 18

[4]

6.80E − 17

[5]

4.86E − 16

[6]

1.02E − 15

[7]

[8]

IL10, IL12A, IL12B, IL13, IRGM, IL16, IL17A, PDGFB, TNFSF12, SPP1, TAGAP, CTSC, IL17B, CD46, BCL2, DEFB103B, CCL26, IL17F, EOMES, DEFB4A, MIF, IL21, C4A, CCL7, CCL11, CCL13, CCL15, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, CX3CL1, NOS2, CXCL12, IL19, GPI, FN1, CXCL13, CASP3, SKI, PPBP, IL23A, IFNA2, LGALS3, IFNB1, IFNG, LIF, ARHGDIB, TRAF4, CSF2, THY1, EBI3, IL20, TIRAP, IL22, LTA, HAMP, IL2, IL3, IL4, IL5, IL6, IL6R, IL7, IL26,IL27, IL9

[26] array · 9 items

[0]

GO:0004888

[1]

[2]

Transmembranesignaling receptor activity

[3]

2.09E − 12

[4]

8.81E − 11

[5]

6.31E − 10

[6]

1.50E − 09

[7]

[8]

IL10RA, IL12B, IL13RA1, HLA-DOB, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, TNFRSF14, TNFRSF10C, PTAFR, PTGER4, IL1RL2, TNFRSF4, PTPN6, IL22RA2, FCER1A, PIGR, FCGR2B, CCR6, CCR8, KIT, KLRB1, LILRB5, SELE, CCR10, XCR1, LILRA1, GPR183, TLR9, CR2, S1PR1, EDNRB, IFNAR1, IFNG, TGFBR1, CD3E, CSF1R, CSF2RB, CSF3R, EBI3, CD44, CD74, CD79A, CD79B, IL1RAP, IL4R, IL6R, CXCR1, CXCR2

[27] array · 9 items

[0]

GO:0001664

[1]

[2]

G protein-coupled receptor binding

[3]

3.80E − 12

[4]

1.52E − 10

[5]

1.08E − 09

[6]

2.73E − 09

[7]

[8]

DEFB103B, CCL26, DEFB1, DEFB4A, CCL7, CCL11, CCL13, CCL15, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, CX3CL1, CXCL12, CXCL13, PPBP, S1PR1, EDNRB, IL2

[28] array · 9 items

[0]

GO:0044877

[1]

[2]

Protein-containing complex binding

[3]

1.24E − 11

[4]

4.46E − 10

[5]

3.19E − 09

[6]

8.92E − 09

[7]

[8]

PDGFB, HLA-DMA, HLA-DMB, HLA-DOB, SPP1, HLA-DRA, HLA-DRB1, PTK2, FCAR, FCER1A, PIGR, FCGR2A, FCGR2B, FCGRT, MIF, C8A, C8B, CX3CL1, CXCL12, VCAM1, DPP4, LILRA2, VTN, FN1, BCL2L11, ICAM2, ICAM3, ICAM4, CASP3, RELA, LCK, IFNA2, LGALS3, IFNB1, TGFBI, TGFBR1, CD3E, BCAP31, CD8A, THY1, CD9, MS4A1, CD22, ICAM5, CD44, CD74, CDH5, CTSS

[29] array · 9 items

[0]

GO:0042802

[1]

[2]

IDENTICAL protein binding

[3]

1.81E − 07

[4]

3.93E − 06

[5]

2.81E − 05

[6]

1.30E − 04

[7]

[8]

IL12B, MASP1, CEBPB, AICDA, PDGFB, CTSC, PECAM1, ETS1, BCL2, IL17F, PTK2, STAT6, DEFB1, CARD9, BTK, KLRF2, MIF, C1S, MME, XCL1, KIT, NOS2, RAG1, DPP4, ICOSLG, TCF4, IKZF2, VTN, FN1, ATG7, ITLN1, AIRE, RELA, RELB, TLR9, LCK, CR2, SLC2A1, LGALS3, TFRC, TRAF4, CD3E, CSF1R, CD8A, TIGIT, TIRAP, CD74, CD79A, CD79B, CDH5, IL6R

[30] array · 9 items

[0]

GO:0046983

[1]

[2]

Protein dimerization activity

[3]

6.79E − 07

[4]

1.19E − 05

[5]

8.51E − 05

[6]

4.88E − 04

[7]

[8]

IL10, IL12A, IL12B, MASP1, CEBPB, PDGFB, HLA-DQA1, PECAM1, GATA3, BCL2, IL17F, BID, CARD9, KLRF2, CCL11, MME, TAL1, XCL1, KIT, NOS2, RAG1, DPP4, TCF4, IKZF2, BCL2L11, ATG7, CXCL13, RELA, TLR9, CR2, LGALS3, TFRC, TGFBR1, TRAF4, CD3E, CSF1R, CD8A, TIRAP, CD79A, CD79B, CDH5, IL6R

[31] array · 9 items

[0]

GO:0016301

[1]

[2]

Kinase activity

[3]

1.16E − 05

[4]

1.54E − 04

[5]

1.10E − 03

[6]

8.29E − 03

[7]

[8]

IL12B, IRGM, PDGFB, MAPKAPK2, PTPN22, PTK2, TNFRSF4, PTPN6, FCER1A, BTK, MIF, CCL19, TAL1, KIT, MAP4K4, NOS2, GPI, DUSP4, CASP3, TLR9, LCK, IL23A, IFNG, TGFBR1, TRAF4, CSF1R, THY1, CD19, EGR1, TIRAP, CD40, IRAK4, CD44, CD74, MAPK11, IL2, IL3, IL4, IL6, IL6R

row_count

column_count

numeric_cells

217

header_rows

locator

section[14]/table-wrap[2]#Tab5

[7] object · 16 fields

asset:table:pmid:33251083:6

role

table

format

jats-table

media_type

application/vnd.jats.table+json

uri

null

sha256

sha256:72eaeba363b965fe7e952d91d5d134b882754beaa91740a8a3be9d2804db13fb

bytes

16979

access

open

state

verified

reader

read_table

reader_status

available

identifier

section[15]/table-wrap[1]#Tab6

version

null

note

Topology table for up and down regulated genes

structure object · 5 fields

pmcid

PMC7679428

section_index

section_title

PPI network construction and module analysis

row_count

277

column_count

table object · 8 fields

label

Table 6

caption

Topology table for up and down regulated genes

rows array · 277 items

[0] array · 7 items

[0]

Regulation

[1]

Node

[2]

Degree

[3]

Betweenness

[4]

Stress

[5]

Closeness

[6]

Clustering Coefficient

[1] array · 7 items

[0]

[1]

TP53

[2]

682

[3]

0.308256

[4]

69419762

[5]

0.44613

[6]

0.001042

[2] array · 7 items

[0]

[1]

HRAS

[2]

543

[3]

0.243425

[4]

36147274

[5]

0.454702

[6]

0.003568

[3] array · 7 items

[0]

[1]

CTNNB1

[2]

454

[3]

0.17049

[4]

60805652

[5]

0.403018

[6]

0.002042

[4] array · 7 items

[0]

[1]

FYN

[2]

396

[3]

0.117564

[4]

12570856

[5]

0.436236

[6]

0.010907

[5] array · 7 items

[0]

[1]

ABL1

[2]

362

[3]

0.118179

[4]

7631538

[5]

0.470883

[6]

0.015228

[6] array · 7 items

[0]

[1]

JAK2

[2]

258

[3]

0.054758

[4]

7164820

[5]

0.434802

[6]

0.021748

[7] array · 7 items

[0]

[1]

STAT3

[2]

253

[3]

0.05294

[4]

16470742

[5]

0.398767

[6]

0.02108

[8] array · 7 items

[0]

[1]

JAK1

[2]

223

[3]

0.032981

[4]

6336566

[5]

0.40235

[6]

0.019876

[9] array · 7 items

[0]

[1]

TRAF6

[2]

216

[3]

0.074546

[4]

12176648

[5]

0.395301

[6]

0.010207

[10] array · 7 items

[0]

[1]

STAT1

[2]

213

[3]

0.045072

[4]

12845532

[5]

0.387307

[6]

0.023031

[11] array · 7 items

[0]

[1]

TRAF2

[2]

171

[3]

0.047572

[4]

11238720

[5]

0.357837

[6]

0.007981

[12] array · 7 items

[0]

[1]

ZAP70

[2]

153

[3]

0.018814

[4]

3346658

[5]

0.375226

[6]

0.028294

[13] array · 7 items

[0]

[1]

IKBKB

[2]

140

[3]

0.040639

[4]

5153454

[5]

0.403521

[6]

0.017575

[14] array · 7 items

[0]

[1]

MX1

[2]

125

[3]

0.057134

[4]

6475242

[5]

0.352549

[6]

0.002194

[15] array · 7 items

[0]

[1]

STAT5B

[2]

118

[3]

0.012758

[4]

2934924

[5]

0.377415

[6]

0.057801

[16] array · 7 items

[0]

[1]

ZBTB16

[2]

105

[3]

0.029011

[4]

4339392

[5]

0.371064

[6]

0.00696

[17] array · 7 items

[0]

[1]

GP1BB

[2]

104

[3]

0.024662

[4]

2308816

[5]

0.350596

[6]

0.009335

[18] array · 7 items

[0]

[1]

RUNX1

[2]

[3]

0.021204

[4]

3579930

[5]

0.370309

[6]

0.010526

[19] array · 7 items

[0]

[1]

C1QBP

[2]

[3]

0.043687

[4]

7011558

[5]

0.334675

[6]

[20] array · 7 items

[0]

[1]

TLR2

[2]

[3]

0.019615

[4]

2401022

[5]

0.374839

[6]

0.034734

[21] array · 7 items

[0]

[1]

SOCS1

[2]

[3]

0.019595

[4]

1846156

[5]

0.398713

[6]

0.072829

[22] array · 7 items

[0]

[1]

SMAD5

[2]

[3]

0.024208

[4]

4462604

[5]

0.336687

[6]

0.003011

[23] array · 7 items

[0]

[1]

ITGB2

[2]

[3]

0.025976

[4]

3349086

[5]

0.351061

[6]

0.008607

[24] array · 7 items

[0]

[1]

IKZF1

[2]

[3]

0.011714

[4]

1722502

[5]

0.373157

[6]

0.034038

[25] array · 7 items

[0]

[1]

CCND3

[2]

[3]

0.025956

[4]

2361424

[5]

0.357661

[6]

0.008048

[26] array · 7 items

[0]

[1]

ATG5

[2]

[3]

0.020131

[4]

2294688

[5]

0.333219

[6]

0.00678

[27] array · 7 items

[0]

[1]

IFIH1

[2]

[3]

0.023459

[4]

2059722

[5]

0.333945

[6]

0.001753

[28] array · 7 items

[0]

[1]

STAT4

[2]

[3]

0.002561

[4]

797810

[5]

0.366902

[6]

0.082275

[29] array · 7 items

[0]

[1]

PSMB9

[2]

[3]

0.0248

[4]

2740768

[5]

0.310739

[6]

[30] array · 7 items

[0]

[1]

IKZF3

[2]

[3]

0.005026

[4]

756292

[5]

0.361346

[6]

0.053654

[31] array · 7 items

[0]

[1]

GFI1

[2]

[3]

0.007563

[4]

811180

[5]

0.357266

[6]

0.013527

[32] array · 7 items

[0]

[1]

IRF7

[2]

[3]

0.010411

[4]

1198488

[5]

0.338804

[6]

0.008457

[33] array · 7 items

[0]

[1]

MAP4K1

[2]

[3]

0.006432

[4]

851692

[5]

0.348957

[6]

0.046512

[34] array · 7 items

[0]

[1]

CD247

[2]

[3]

0.00724

[4]

710792

[5]

0.349292

[6]

0.058693

[35] array · 7 items

[0]

[1]

LCP2

[2]

[3]

0.003353

[4]

442356

[5]

0.338331

[6]

0.07439

[36] array · 7 items

[0]

[1]

CCR5

[2]

[3]

0.010719

[4]

942222

[5]

0.343359

[6]

0.043185

[37] array · 7 items

[0]

[1]

IRF5

[2]

[3]

0.006222

[4]

736764

[5]

0.339277

[6]

0.012478

[38] array · 7 items

[0]

[1]

GZMB

[2]

[3]

0.01009

[4]

1297184

[5]

0.313584

[6]

[39] array · 7 items

[0]

[1]

IL2RG

[2]

[3]

0.005284

[4]

347620

[5]

0.3463

[6]

0.071225

[40] array · 7 items

[0]

[1]

TBX21

[2]

[3]

0.003781

[4]

493896

[5]

0.328704

[6]

0.023715

[41] array · 7 items

[0]

[1]

XBP1

[2]

[3]

0.004344

[4]

440004

[5]

0.329933

[6]

[42] array · 7 items

[0]

[1]

HLA-A

[2]

[3]

0.007447

[4]

822622

[5]

0.311637

[6]

[43] array · 7 items

[0]

[1]

MAP4K2

[2]

[3]

0.002038

[4]

190802

[5]

0.334636

[6]

0.045752

[44] array · 7 items

[0]

[1]

CCR1

[2]

[3]

0.004542

[4]

722956

[5]

0.323912

[6]

0.019608

[45] array · 7 items

[0]

[1]

IFNAR2

[2]

[3]

0.003686

[4]

214358

[5]

0.335872

[6]

0.169118

[46] array · 7 items

[0]

[1]

ITGAL

[2]

[3]

0.004258

[4]

302784

[5]

0.285588

[6]

0.058824

[47] array · 7 items

[0]

[1]

ATG10

[2]

[3]

0.00303

[4]

204222

[5]

0.278618

[6]

0.075

[48] array · 7 items

[0]

[1]

CEACAM1

[2]

[3]

0.003567

[4]

815206

[5]

0.308991

[6]

[49] array · 7 items

[0]

[1]

CLEC7A

[2]

[3]

0.006223

[4]

422114

[5]

0.302253

[6]

[50] array · 7 items

[0]

[1]

CUL9

[2]

[3]

0.001917

[4]

66468

[5]

0.352806

[6]

0.111111

[51] array · 7 items

[0]

[1]

SERPING1

[2]

[3]

0.004857

[4]

805696

[5]

0.203225

[6]

[52] array · 7 items

[0]

[1]

NLRP3

[2]

[3]

0.002325

[4]

208526

[5]

0.304371

[6]

[53] array · 7 items

[0]

[1]

LTB4R

[2]

[3]

0.002812

[4]

970594

[5]

0.242059

[6]

[54] array · 7 items

[0]

[1]

GBP1

[2]

[3]

0.001571

[4]

66852

[5]

0.307489

[6]

[55] array · 7 items

[0]

[1]

LILRB2

[2]

[3]

0.004803

[4]

191694

[5]

0.287677

[6]

[56] array · 7 items

[0]

[1]

CD99

[2]

[3]

0.002792

[4]

99752

[5]

0.324129

[6]

[57] array · 7 items

[0]

[1]

KLRK1

[2]

[3]

0.003445

[4]

544176

[5]

0.26256

[6]

[58] array · 7 items

[0]

[1]

BST2

[2]

[3]

1.93E − 04

[4]

36836

[5]

0.324273

[6]

[59] array · 7 items

[0]

[1]

KLRD1

[2]

[3]

0.001389

[4]

97132

[5]

0.22517

[6]

0.047619

[60] array · 7 items

[0]

[1]

KLRC1

[2]

[3]

0.003221

[4]

307724

[5]

0.286234

[6]

0.1

[61] array · 7 items

[0]

[1]

IL18R1

[2]

[3]

0.00118

[4]

348338

[5]

0.245924

[6]

[62] array · 7 items

[0]

[1]

PDCD1

[2]

[3]

0.001374

[4]

55018

[5]

0.303894

[6]

0.166667

[63] array · 7 items

[0]

[1]

SLAMF7

[2]

[3]

0.00206

[4]

191070

[5]

0.233272

[6]

[64] array · 7 items

[0]

[1]

[2]

[3]

0.001446

[4]

96444

[5]

0.245447

[6]

[65] array · 7 items

[0]

[1]

IFI35

[2]

[3]

6.93E − 04

[4]

23710

[5]

0.323301

[6]

[66] array · 7 items

[0]

[1]

LAG3

[2]

[3]

4.23E − 06

[4]

1074

[5]

0.245695

[6]

[67] array · 7 items

[0]

[1]

IL18RAP

[2]

[3]

1.95E − 04

[4]

52194

[5]

0.233609

[6]

[68] array · 7 items

[0]

Down

[1]

MAPK11

[2]

421

[3]

0.179413

[4]

26118522

[5]

0.388195

[6]

0.003744

[69] array · 7 items

[0]

Down

[1]

RELA

[2]

285

[3]

0.126824

[4]

20931198

[5]

0.37804

[6]

0.004645

[70] array · 7 items

[0]

Down

[1]

LCK

[2]

267

[3]

0.108492

[4]

11305268

[5]

0.405534

[6]

0.014108

[71] array · 7 items

[0]

Down

[1]

KIT

[2]

221

[3]

0.051071

[4]

10158794

[5]

0.36783

[6]

0.015014

[72] array · 7 items

[0]

Down

[1]

EGR1

[2]

195

[3]

0.060886

[4]

6334914

[5]

0.384414

[6]

0.016178

[73] array · 7 items

[0]

Down

[1]

ILF3

[2]

179

[3]

0.093546

[4]

7805892

[5]

0.330116

[6]

3.14E − 04

[74] array · 7 items

[0]

Down

[1]

CASP3

[2]

175

[3]

0.070326

[4]

10842834

[5]

0.355181

[6]

0.005123

[75] array · 7 items

[0]

Down

[1]

PTK2

[2]

153

[3]

0.049652

[4]

8738870

[5]

0.356704

[6]

0.005246

[76] array · 7 items

[0]

Down

[1]

PTPN6

[2]

150

[3]

0.044684

[4]

5323296

[5]

0.365645

[6]

0.021477

[77] array · 7 items

[0]

Down

[1]

BCL2

[2]

150

[3]

0.062256

[4]

5772430

[5]

0.365862

[6]

0.009128

[78] array · 7 items

[0]

Down

[1]

BTK

[2]

137

[3]

0.022999

[4]

3449618

[5]

0.35359

[6]

0.019429

[79] array · 7 items

[0]

Down

[1]

STAT5A

[2]

126

[3]

0.024378

[4]

5096524

[5]

0.35745

[6]

0.027429

[80] array · 7 items

[0]

Down

[1]

TGFBR1

[2]

123

[3]

0.048955

[4]

6050368

[5]

0.349257

[6]

0.007464

[81] array · 7 items

[0]

Down

[1]

CSF1R

[2]

117

[3]

0.01327

[4]

3411424

[5]

0.344835

[6]

0.005894

[82] array · 7 items

[0]

Down

[1]

FN1

[2]

116

[3]

0.052141

[4]

5201654

[5]

0.335331

[6]

0.003148

[83] array · 7 items

[0]

Down

[1]

TCF4

[2]

115

[3]

0.044569

[4]

5794596

[5]

0.333586

[6]

0.005492

[84] array · 7 items

[0]

Down

[1]

TRAF3

[2]

113

[3]

0.038869

[4]

4088284

[5]

0.341886

[6]

0.010588

[85] array · 7 items

[0]

Down

[1]

STAT6

[2]

102

[3]

0.026319

[4]

3212830

[5]

0.363486

[6]

0.039216

[86] array · 7 items

[0]

Down

[1]

GATA3

[2]

[3]

0.03064

[4]

3006348

[5]

0.350689

[6]

0.018471

[87] array · 7 items

[0]

Down

[1]

IRAK4

[2]

[3]

0.015953

[4]

2526624

[5]

0.344064

[6]

0.010986

[88] array · 7 items

[0]

Down

[1]

TCF7

[2]

[3]

0.029254

[4]

4190222

[5]

0.323796

[6]

9.99E − 04

[89] array · 7 items

[0]

Down

[1]

ATG7

[2]

[3]

0.032475

[4]

4557368

[5]

0.323761

[6]

[90] array · 7 items

[0]

Down

[1]

PSMB10

[2]

[3]

0.037084

[4]

3948650

[5]

0.316536

[6]

[91] array · 7 items

[0]

Down

[1]

EGR2

[2]

[3]

0.014472

[4]

2942228

[5]

0.323966

[6]

0.002331

[92] array · 7 items

[0]

Down

[1]

CEBPB

[2]

[3]

0.01563

[4]

2080316

[5]

0.347208

[6]

0.028708

[93] array · 7 items

[0]

Down

[1]

TLR9

[2]

[3]

0.01613

[4]

2504516

[5]

0.335623

[6]

0.017658

[94] array · 7 items

[0]

Down

[1]

ETS1

[2]

[3]

0.015119

[4]

2229504

[5]

0.345493

[6]

0.023695

[95] array · 7 items

[0]

Down

[1]

MBP

[2]

[3]

0.02034

[4]

1946892

[5]

0.33211

[6]

0.008099

[96] array · 7 items

[0]

Down

[1]

CD40

[2]

[3]

0.012367

[4]

1565636

[5]

0.343144

[6]

0.030722

[97] array · 7 items

[0]

Down

[1]

PTPN22

[2]

[3]

0.005103

[4]

648768

[5]

0.333009

[6]

0.039939

[98] array · 7 items

[0]

Down

[1]

CXCL13

[2]

[3]

0.033409

[4]

4616616

[5]

0.255924

[6]

0.002644

[99] array · 7 items

[0]

Down

[1]

CD44

[2]

[3]

0.027234

[4]

2621678

[5]

0.352941

[6]

0.016393

[100] array · 7 items

[0]

Down

[1]

DUSP4

[2]

[3]

0.005964

[4]

877004

[5]

0.343106

[6]

0.046753

[101] array · 7 items

[0]

Down

[1]

TOLLIP

[2]

[3]

0.020841

[4]

1681614

[5]

0.32948

[6]

0.011448

[102] array · 7 items

[0]

Down

[1]

TRAF4

[2]

[3]

0.017367

[4]

1322968

[5]

0.327447

[6]

0.012579

[103] array · 7 items

[0]

Down

[1]

TFRC

[2]

[3]

0.020865

[4]

2030850

[5]

0.323932

[6]

7.84E − 04

[104] array · 7 items

[0]

Down

[1]

TAL1

[2]

[3]

0.012074

[4]

1294452

[5]

0.327273

[6]

0.02551

[105] array · 7 items

[0]

Down

[1]

BATF3

[2]

[3]

0.009925

[4]

1237560

[5]

0.309471

[6]

0.011525

[106] array · 7 items

[0]

Down

[1]

SKI

[2]

[3]

0.009912

[4]

1441494

[5]

0.325026

[6]

0.010176

[107] array · 7 items

[0]

Down

[1]

MAP4K4

[2]

[3]

0.00723

[4]

923942

[5]

0.334966

[6]

0.025121

[108] array · 7 items

[0]

Down

[1]

ARHGDIB

[2]

[3]

0.008007

[4]

998356

[5]

0.325267

[6]

0.00443

[109] array · 7 items

[0]

Down

[1]

BID

[2]

[3]

0.007734

[4]

665116

[5]

0.336026

[6]

0.046154

[110] array · 7 items

[0]

Down

[1]

BCL2L11

[2]

[3]

0.006742

[4]

718322

[5]

0.327935

[6]

0.032389

[111] array · 7 items

[0]

Down

[1]

NOS2

[2]

[3]

0.012743

[4]

915032

[5]

0.332218

[6]

0.010796

[112] array · 7 items

[0]

Down

[1]

AICDA

[2]

[3]

0.016444

[4]

2864544

[5]

0.288094

[6]

[113] array · 7 items

[0]

Down

[1]

GPI

[2]

[3]

0.009895

[4]

1400722

[5]

0.322202

[6]

[114] array · 7 items

[0]

Down

[1]

CSF2RB

[2]

[3]

0.005071

[4]

681430

[5]

0.345571

[6]

0.100601

[115] array · 7 items

[0]

Down

[1]

TIRAP

[2]

[3]

0.009595

[4]

1070880

[5]

0.324

[6]

0.033033

[116] array · 7 items

[0]

Down

[1]

CD9

[2]

[3]

0.01001

[4]

838100

[5]

0.302685

[6]

0.019048

[117] array · 7 items

[0]

Down

[1]

CDH5

[2]

[3]

0.00845

[4]

737334

[5]

0.306177

[6]

0.013445

[118] array · 7 items

[0]

Down

[1]

AIRE

[2]

[3]

0.010893

[4]

2140272

[5]

0.292753

[6]

[119] array · 7 items

[0]

Down

[1]

CD82

[2]

[3]

0.008605

[4]

911074

[5]

0.323659

[6]

0.020161

[120] array · 7 items

[0]

Down

[1]

IFNAR1

[2]

[3]

0.006943

[4]

536824

[5]

0.340902

[6]

0.062366

[121] array · 7 items

[0]

Down

[1]

CD3E

[2]

[3]

0.006779

[4]

602042

[5]

0.338614

[6]

0.078161

[122] array · 7 items

[0]

Down

[1]

LGALS3

[2]

[3]

0.009645

[4]

633882

[5]

0.302536

[6]

[123] array · 7 items

[0]

Down

[1]

VTN

[2]

[3]

0.009755

[4]

750034

[5]

0.299445

[6]

0.006897

[124] array · 7 items

[0]

Down

[1]

CD8A

[2]

[3]

0.008368

[4]

709958

[5]

0.334638

[6]

0.029557

[125] array · 7 items

[0]

Down

[1]

CSF3R

[2]

[3]

0.008229

[4]

711320

[5]

0.334093

[6]

0.029101

[126] array · 7 items

[0]

Down

[1]

EOMES

[2]

[3]

0.005201

[4]

513270

[5]

0.277597

[6]

0.018519

[127] array · 7 items

[0]

Down

[1]

VCAM1

[2]

[3]

0.008841

[4]

718322

[5]

0.31732

[6]

0.010582

[128] array · 7 items

[0]

Down

[1]

ZEB1

[2]

[3]

0.006122

[4]

1257304

[5]

0.288851

[6]

[129] array · 7 items

[0]

Down

[1]

MME

[2]

[3]

0.009061

[4]

1835908

[5]

0.290624

[6]

0.014245

[130] array · 7 items

[0]

Down

[1]

MIF

[2]

[3]

0.00826

[4]

611016

[5]

0.321596

[6]

0.005698

[131] array · 7 items

[0]

Down

[1]

IKZF2

[2]

[3]

0.003358

[4]

390862

[5]

0.3129

[6]

[132] array · 7 items

[0]

Down

[1]

MAPKAPK2

[2]

[3]

0.004801

[4]

451358

[5]

0.310909

[6]

0.024615

[133] array · 7 items

[0]

Down

[1]

PLAU

[2]

[3]

0.008975

[4]

593824

[5]

0.317844

[6]

0.01

[134] array · 7 items

[0]

Down

[1]

DPP4

[2]

[3]

0.010538

[4]

1418468

[5]

0.265231

[6]

0.006667

[135] array · 7 items

[0]

Down

[1]

RORC

[2]

[3]

0.00722

[4]

1661398

[5]

0.278729

[6]

0.013333

[136] array · 7 items

[0]

Down

[1]

CD55

[2]

[3]

0.010279

[4]

705586

[5]

0.303102

[6]

[137] array · 7 items

[0]

Down

[1]

IL4R

[2]

[3]

0.00238

[4]

270352

[5]

0.331181

[6]

0.083333

[138] array · 7 items

[0]

Down

[1]

CD19

[2]

[3]

0.001702

[4]

211728

[5]

0.304301

[6]

0.090909

[139] array · 7 items

[0]

Down

[1]

IRF8

[2]

[3]

0.005195

[4]

372574

[5]

0.329904

[6]

0.019763

[140] array · 7 items

[0]

Down

[1]

IL4

[2]

[3]

0.004905

[4]

441962

[5]

0.296246

[6]

0.019763

[141] array · 7 items

[0]

Down

[1]

RELB

[2]

[3]

0.003464

[4]

286340

[5]

0.326336

[6]

0.055336

[142] array · 7 items

[0]

Down

[1]

PAX5

[2]

[3]

0.002896

[4]

300204

[5]

0.291726

[6]

0.021645

[143] array · 7 items

[0]

Down

[1]

CXCR2

[2]

[3]

0.006344

[4]

1097670

[5]

0.26098

[6]

0.047619

[144] array · 7 items

[0]

Down

[1]

IL16

[2]

[3]

0.008141

[4]

455702

[5]

0.300821

[6]

[145] array · 7 items

[0]

Down

[1]

SPP1

[2]

[3]

0.005095

[4]

320668

[5]

0.307124

[6]

0.014286

[146] array · 7 items

[0]

Down

[1]

THY1

[2]

[3]

0.008614

[4]

468640

[5]

0.309285

[6]

0.004762

[147] array · 7 items

[0]

Down

[1]

SLC2A1

[2]

[3]

0.00547

[4]

544898

[5]

0.316244

[6]

[148] array · 7 items

[0]

Down

[1]

EDNRB

[2]

[3]

0.006473

[4]

488214

[5]

0.313729

[6]

[149] array · 7 items

[0]

Down

[1]

SELE

[2]

[3]

0.005852

[4]

411150

[5]

0.300615

[6]

0.031579

[150] array · 7 items

[0]

Down

[1]

HLA-DRA

[2]

[3]

0.004735

[4]

398954

[5]

0.319992

[6]

0.052288

[151] array · 7 items

[0]

Down

[1]

CD79A

[2]

[3]

0.00478

[4]

297512

[5]

0.338726

[6]

0.176471

[152] array · 7 items

[0]

Down

[1]

HLA-B

[2]

[3]

0.006176

[4]

428434

[5]

0.315111

[6]

0.022059

[153] array · 7 items

[0]

Down

[1]

BCAP31

[2]

[3]

0.005172

[4]

568664

[5]

0.289476

[6]

0.058824

[154] array · 7 items

[0]

Down

[1]

IL1RAP

[2]

[3]

0.003059

[4]

257852

[5]

0.322101

[6]

0.088235

[155] array · 7 items

[0]

Down

[1]

PDGFB

[2]

[3]

0.003308

[4]

533330

[5]

0.27399

[6]

[156] array · 7 items

[0]

Down

[1]

S1PR1

[2]

[3]

0.002256

[4]

404754

[5]

0.320025

[6]

[157] array · 7 items

[0]

Down

[1]

CD46

[2]

[3]

0.004006

[4]

360234

[5]

0.31814

[6]

0.047619

[158] array · 7 items

[0]

Down

[1]

RAG1

[2]

[3]

0.002698

[4]

229148

[5]

0.267304

[6]

0.019048

[159] array · 7 items

[0]

Down

[1]

CD22

[2]

[3]

0.003395

[4]

414458

[5]

0.289123

[6]

0.07619

[160] array · 7 items

[0]

Down

[1]

POU2F2

[2]

[3]

0.00252

[4]

256428

[5]

0.313506

[6]

[161] array · 7 items

[0]

Down

[1]

TNFRSF14

[2]

[3]

0.002863

[4]

205148

[5]

0.290131

[6]

0.054945

[162] array · 7 items

[0]

Down

[1]

FCGR2B

[2]

[3]

0.001419

[4]

233096

[5]

0.299854

[6]

0.087912

[163] array · 7 items

[0]

Down

[1]

CSF2

[2]

[3]

0.001964

[4]

189924

[5]

0.271764

[6]

0.076923

[164] array · 7 items

[0]

Down

[1]

SELPLG

[2]

[3]

0.004641

[4]

618406

[5]

0.266933

[6]

0.010989

[165] array · 7 items

[0]

Down

[1]

IL10

[2]

[3]

0.001286

[4]

131502

[5]

0.275387

[6]

0.025641

[166] array · 7 items

[0]

Down

[1]

CCL7

[2]

[3]

0.002891

[4]

346838

[5]

0.240789

[6]

[167] array · 7 items

[0]

Down

[1]

CD79B

[2]

[3]

3.06E − 04

[4]

78608

[5]

0.337796

[6]

0.423077

[168] array · 7 items

[0]

Down

[1]

HLA-C

[2]

[3]

0.003625

[4]

407006

[5]

0.310407

[6]

0.025641

[169] array · 7 items

[0]

Down

[1]

IL6R

[2]

[3]

0.004275

[4]

289876

[5]

0.288689

[6]

0.051282

[170] array · 7 items

[0]

Down

[1]

IL17A

[2]

[3]

0.002334

[4]

388710

[5]

0.280328

[6]

0.025641

[171] array · 7 items

[0]

Down

[1]

FCGR2A

[2]

[3]

0.002143

[4]

252800

[5]

0.318403

[6]

[172] array · 7 items

[0]

Down

[1]

LTA

[2]

[3]

0.002886

[4]

476206

[5]

0.257315

[6]

[173] array · 7 items

[0]

Down

[1]

CXCL12

[2]

[3]

0.005496

[4]

372448

[5]

0.27655

[6]

0.030303

[174] array · 7 items

[0]

Down

[1]

CTSS

[2]

[3]

0.00407

[4]

451030

[5]

0.260472

[6]

[175] array · 7 items

[0]

Down

[1]

CD59

[2]

[3]

0.004363

[4]

207460

[5]

0.290405

[6]

0.030303

[176] array · 7 items

[0]

Down

[1]

CXCR1

[2]

[3]

8.07E − 04

[4]

176404

[5]

0.242095

[6]

0.166667

[177] array · 7 items

[0]

Down

[1]

IL2

[2]

[3]

0.002493

[4]

217616

[5]

0.290487

[6]

0.030303

[178] array · 7 items

[0]

Down

[1]

[2]

[3]

9.26E − 04

[4]

133246

[5]

0.24911

[6]

[179] array · 7 items

[0]

Down

[1]

CD74

[2]

[3]

0.003192

[4]

267306

[5]

0.315369

[6]

0.121212

[180] array · 7 items

[0]

Down

[1]

CR2

[2]

[3]

0.001319

[4]

143504

[5]

0.267072

[6]

0.036364

[181] array · 7 items

[0]

Down

[1]

CCR10

[2]

[3]

0.003702

[4]

303034

[5]

0.222963

[6]

0.072727

[182] array · 7 items

[0]

Down

[1]

CTSC

[2]

[3]

0.004925

[4]

257558

[5]

0.302268

[6]

[183] array · 7 items

[0]

Down

[1]

TGFBI

[2]

[3]

7.77E − 04

[4]

51700

[5]

0.253167

[6]

0.155556

[184] array · 7 items

[0]

Down

[1]

CD209

[2]

[3]

4.47E − 04

[4]

37928

[5]

0.243628

[6]

0.044444

[185] array · 7 items

[0]

Down

[1]

NT5E

[2]

[3]

0.003249

[4]

169846

[5]

0.314627

[6]

0.022222

[186] array · 7 items

[0]

Down

[1]

IL10RA

[2]

[3]

0.001722

[4]

123836

[5]

0.32116

[6]

0.155556

[187] array · 7 items

[0]

Down

[1]

MBL2

[2]

[3]

0.002733

[4]

247190

[5]

0.248106

[6]

0.027778

[188] array · 7 items

[0]

Down

[1]

TNFRSF9

[2]

[3]

0.001065

[4]

77604

[5]

0.309005

[6]

0.305556

[189] array · 7 items

[0]

Down

[1]

HLA-DQA1

[2]

[3]

8.50E − 04

[4]

84902

[5]

0.306147

[6]

0.194444

[190] array · 7 items

[0]

Down

[1]

NFIL3

[2]

[3]

0.002148

[4]

269802

[5]

0.253063

[6]

[191] array · 7 items

[0]

Down

[1]

MS4A1

[2]

[3]

6.53E − 04

[4]

54246

[5]

0.308664

[6]

0.083333

[192] array · 7 items

[0]

Down

[1]

PTAFR

[2]

[3]

0.001839

[4]

146258

[5]

0.315401

[6]

0.055556

[193] array · 7 items

[0]

Down

[1]

MASP1

[2]

[3]

0.002137

[4]

326806

[5]

0.225528

[6]

0.083333

[194] array · 7 items

[0]

Down

[1]

PLA2G2A

[2]

[3]

0.002039

[4]

625578

[5]

0.228338

[6]

[195] array · 7 items

[0]

Down

[1]

TNFRSF4

[2]

[3]

7.20E − 04

[4]

87330

[5]

0.26198

[6]

0.321429

[196] array · 7 items

[0]

Down

[1]

IL13RA1

[2]

[3]

6.92E − 04

[4]

54632

[5]

0.3129

[6]

0.214286

[197] array · 7 items

[0]

Down

[1]

CD48

[2]

[3]

0.001004

[4]

75166

[5]

0.297881

[6]

0.142857

[198] array · 7 items

[0]

Down

[1]

CD244

[2]

[3]

0.001314

[4]

270208

[5]

0.265574

[6]

0.071429

[199] array · 7 items

[0]

Down

[1]

HLA-DRB1

[2]

[3]

0.001343

[4]

119046

[5]

0.273066

[6]

0.142857

[200] array · 7 items

[0]

Down

[1]

IL12A

[2]

[3]

0.003272

[4]

296440

[5]

0.241412

[6]

0.071429

[201] array · 7 items

[0]

Down

[1]

ICAM3

[2]

[3]

6.74E − 04

[4]

94610

[5]

0.255118

[6]

0.035714

[202] array · 7 items

[0]

Down

[1]

ICAM2

[2]

[3]

7.74E − 04

[4]

115578

[5]

0.242687

[6]

0.047619

[203] array · 7 items

[0]

Down

[1]

CD86

[2]

[3]

0.00143

[4]

76566

[5]

0.302417

[6]

0.190476

[204] array · 7 items

[0]

Down

[1]

IL6

[2]

[3]

0.001988

[4]

115352

[5]

0.260582

[6]

0.095238

[205] array · 7 items

[0]

Down

[1]

CD80

[2]

[3]

0.001335

[4]

74000

[5]

0.254317

[6]

0.190476

[206] array · 7 items

[0]

Down

[1]

CCL13

[2]

[3]

3.79E − 04

[4]

117758

[5]

0.239347

[6]

[207] array · 7 items

[0]

Down

[1]

CARD9

[2]

[3]

0.001358

[4]

152030

[5]

0.262583

[6]

[208] array · 7 items

[0]

Down

[1]

MASP2

[2]

[3]

8.34E − 04

[4]

73116

[5]

0.210649

[6]

0.2

[209] array · 7 items

[0]

Down

[1]

HLA-DMA

[2]

[3]

0.001965

[4]

186844

[5]

0.252792

[6]

0.2

[210] array · 7 items

[0]

Down

[1]

FCER1A

[2]

[3]

0.001958

[4]

462984

[5]

0.26283

[6]

[211] array · 7 items

[0]

Down

[1]

IL13

[2]

[3]

9.18E − 04

[4]

81904

[5]

0.260164

[6]

0.2

[212] array · 7 items

[0]

Down

[1]

PIGR

[2]

[3]

0.001383

[4]

46460

[5]

0.267211

[6]

[213] array · 7 items

[0]

Down

[1]

ICAM4

[2]

[3]

7.08E − 04

[4]

122662

[5]

0.244131

[6]

[214] array · 7 items

[0]

Down

[1]

CCL11

[2]

[3]

4.36E − 04

[4]

106892

[5]

0.239682

[6]

[215] array · 7 items

[0]

Down

[1]

FCAR

[2]

[3]

0.001325

[4]

60556

[5]

0.281404

[6]

0.066667

[216] array · 7 items

[0]

Down

[1]

PTGER4

[2]

[3]

0.001594

[4]

111600

[5]

0.311981

[6]

[217] array · 7 items

[0]

Down

[1]

RAG2

[2]

[3]

0.002235

[4]

108180

[5]

0.302893

[6]

0.133333

[218] array · 7 items

[0]

Down

[1]

PPBP

[2]

[3]

0.00149

[4]

101978

[5]

0.25057

[6]

0.066667

[219] array · 7 items

[0]

Down

[1]

IL3

[2]

[3]

1.42E − 05

[4]

4398

[5]

0.276848

[6]

0.133333

[220] array · 7 items

[0]

Down

[1]

HLA-DQB1

[2]

[3]

1.37E − 04

[4]

32052

[5]

0.304361

[6]

0.5

[221] array · 7 items

[0]

Down

[1]

IDO1

[2]

[3]

0.002598

[4]

124836

[5]

0.300263

[6]

[222] array · 7 items

[0]

Down

[1]

TNFRSF10C

[2]

[3]

6.74E − 04

[4]

112660

[5]

0.252006

[6]

[223] array · 7 items

[0]

Down

[1]

TNFRSF13C

[2]

[3]

6.50E − 04

[4]

58590

[5]

0.256308

[6]

0.3

[224] array · 7 items

[0]

Down

[1]

IL17F

[2]

[3]

2.32E − 04

[4]

81308

[5]

0.256031

[6]

0.2

[225] array · 7 items

[0]

Down

[1]

CFD

[2]

[3]

0.001535

[4]

135276

[5]

0.301765

[6]

[226] array · 7 items

[0]

Down

[1]

CCL19

[2]

[3]

8.76E − 05

[4]

9268

[5]

0.219387

[6]

0.4

[227] array · 7 items

[0]

Down

[1]

CD34

[2]

[3]

0.001329

[4]

226272

[5]

0.243224

[6]

[228] array · 7 items

[0]

Down

[1]

IFNG

[2]

[3]

0.001405

[4]

110736

[5]

0.270285

[6]

[229] array · 7 items

[0]

Down

[1]

IL23A

[2]

[3]

0.00132

[4]

310874

[5]

0.180846

[6]

0.1

[230] array · 7 items

[0]

Down

[1]

EBI3

[2]

[3]

0.001288

[4]

90012

[5]

0.222769

[6]

0.1

[231] array · 7 items

[0]

Down

[1]

C8B

[2]

[3]

2.59E − 04

[4]

21386

[5]

0.208212

[6]

0.166667

[232] array · 7 items

[0]

Down

[1]

CCL20

[2]

[3]

0.001697

[4]

215266

[5]

0.242974

[6]

[233] array · 7 items

[0]

Down

[1]

C4BPA

[2]

[3]

0.001305

[4]

202342

[5]

0.207217

[6]

[234] array · 7 items

[0]

Down

[1]

C8A

[2]

[3]

5.17E − 04

[4]

27442

[5]

0.225528

[6]

0.333333

[235] array · 7 items

[0]

Down

[1]

SLAMF6

[2]

[3]

6.38E − 06

[4]

766

[5]

0.274209

[6]

0.333333

[236] array · 7 items

[0]

Down

[1]

CCR6

[2]

[3]

0.001956

[4]

273648

[5]

0.209231

[6]

[237] array · 7 items

[0]

Down

[1]

BTLA

[2]

[3]

6.84E − 04

[4]

61880

[5]

0.275584

[6]

0.333333

[238] array · 7 items

[0]

Down

[1]

CCR8

[2]

[3]

6.64E − 04

[4]

48144

[5]

0.196954

[6]

[239] array · 7 items

[0]

Down

[1]

CXCL11

[2]

[3]

8.55E − 05

[4]

11782

[5]

0.220629

[6]

[240] array · 7 items

[0]

Down

[1]

SIGIRR

[2]

[3]

3.08E − 06

[4]

666

[5]

0.277147

[6]

0.333333

[241] array · 7 items

[0]

Down

[1]

ITLN1

[2]

[3]

0.001313

[4]

85710

[5]

0.272679

[6]

[242] array · 7 items

[0]

Down

[1]

ICAM5

[2]

[3]

3.97E − 05

[4]

5052

[5]

0.242936

[6]

[243] array · 7 items

[0]

Down

[1]

FCGRT

[2]

[3]

0.001307

[4]

236680

[5]

0.210779

[6]

[244] array · 7 items

[0]

Down

[1]

CCL22

[2]

[3]

5.04E − 04

[4]

43848

[5]

0.247169

[6]

[245] array · 7 items

[0]

Down

[1]

IL12B

[2]

[3]

1.64E − 04

[4]

39054

[5]

0.194859

[6]

0.5

[246] array · 7 items

[0]

Down

[1]

IL27

[2]

[3]

2.87E − 04

[4]

26194

[5]

0.215697

[6]

0.333333

[247] array · 7 items

[0]

Down

[1]

IL22

[2]

[3]

6.54E − 04

[4]

37474

[5]

0.199417

[6]

[248] array · 7 items

[0]

Down

[1]

[2]

[3]

1.54E − 04

[4]

29126

[5]

0.226657

[6]

[249] array · 7 items

[0]

Down

[1]

TIGIT

[2]

[3]

0.001299

[4]

79710

[5]

0.18742

[6]

[250] array · 7 items

[0]

Down

[1]

DEFB4A

[2]

[3]

0.002265

[4]

309432

[5]

0.250917

[6]

[251] array · 7 items

[0]

Down

[1]

IL22RA2

[2]

[3]

8.49E − 04

[4]

82918

[5]

0.216806

[6]

[252] array · 7 items

[0]

Down

[1]

IL21

[2]

[3]

2.06E − 05

[4]

882

[5]

0.21301

[6]

[253] array · 7 items

[0]

Down

[1]

[2]

[3]

1.97E − 05

[4]

976

[5]

0.229359

[6]

0.333333

[254] array · 7 items

[0]

Down

[1]

LIF

[2]

[3]

1.35E − 05

[4]

994

[5]

0.252689

[6]

[255] array · 7 items

[0]

Down

[1]

ITGAE

[2]

[3]

6.54E − 04

[4]

122018

[5]

0.226607

[6]

[256] array · 7 items

[0]

Down

[1]

IL5

[2]

[3]

2.60E − 05

[4]

1936

[5]

0.26283

[6]

0.333333

[257] array · 7 items

[0]

Down

[1]

HLA-DPB1

[2]

[3]

[4]

[5]

0.240356

[6]

[258] array · 7 items

[0]

Down

[1]

CFI

[2]

[3]

6.50E − 04

[4]

65960

[5]

0.196527

[6]

[259] array · 7 items

[0]

Down

[1]

IFNB1

[2]

[3]

[4]

[5]

0.254275

[6]

[260] array · 7 items

[0]

Down

[1]

IFNA2

[2]

[3]

[4]

[5]

0.254275

[6]

[261] array · 7 items

[0]

Down

[1]

XCL1

[2]

[3]

0.001299

[4]

97076

[5]

0.208706

[6]

[262] array · 7 items

[0]

Down

[1]

CD1A

[2]

[3]

6.50E − 04

[4]

79654

[5]

0.20475

[6]

[263] array · 7 items

[0]

Down

[1]

XCR1

[2]

[3]

6.50E − 04

[4]

48540

[5]

0.172698

[6]

[264] array · 7 items

[0]

Down

[1]

DEFB103B

[2]

[3]

6.50E − 04

[4]

91060

[5]

0.173057

[6]

[265] array · 7 items

[0]

Down

[1]

IL7

[2]

[3]

6.20E − 07

[4]

[5]

0.219497

[6]

[266] array · 7 items

[0]

Down

[1]

KLRB1

[2]

[3]

6.50E − 04

[4]

58078

[5]

0.267815

[6]

[267] array · 7 items

[0]

Down

[1]

IL20

[2]

[3]

0.666667

[4]

[5]

0.75

[6]

[268] array · 7 items

[0]

Down

[1]

HLA-DMB

[2]

[3]

[4]

[5]

0.201796

[6]

[269] array · 7 items

[0]

Down

[1]

HLA-DOB

[2]

[3]

[4]

[5]

0.16794

[6]

[270] array · 7 items

[0]

Down

[1]

ICOSLG

[2]

[3]

[4]

[5]

0.200469

[6]

[271] array · 7 items

[0]

Down

[1]

CD83

[2]

[3]

[4]

[5]

0.300029

[6]

[272] array · 7 items

[0]

Down

[1]

GPR183

[2]

[3]

[4]

[5]

0.300029

[6]

[273] array · 7 items

[0]

Down

[1]

IKBKAP

[2]

[3]

[4]

[5]

0.250938

[6]

[274] array · 7 items

[0]

Down

[1]

DEFB1

[2]

[3]

[4]

[5]

0.173038

[6]

[275] array · 7 items

[0]

Down

[1]

IL1RL2

[2]

[3]

[4]

[5]

0.20772

[6]

[276] array · 7 items

[0]

Down

[1]

IL19

[2]

[3]

[4]

[5]

0.5

[6]

row_count

277

column_count

numeric_cells

1443

header_rows

locator

section[15]/table-wrap[1]#Tab6

[8] object · 16 fields

asset:table:pmid:33251083:7

role

table

format

jats-table

media_type

application/vnd.jats.table+json

uri

null

sha256

sha256:9f3e4a1eac95f4caba623fab38d02663f148640b1982a308e2735b6d1ad0a952

bytes

10788

access

open

state

verified

reader

read_table

reader_status

available

identifier

section[16]/table-wrap[1]#Tab7

version

null

note

miRNA - target gene interaction table

structure object · 5 fields

pmcid

PMC7679428

section_index

section_title

Construction of target gene–miRNA regulatory network

row_count

185

column_count

table object · 8 fields

label

Table 7

caption

miRNA - target gene interaction table

rows array · 185 items

[0] array · 8 items

[0]

Regulation

[1]

Target Genes

[2]

Degree

[3]

MicroRNA

[4]

Regulation

[5]

Target Genes

[6]

Degree

[7]

MicroRNA

[1] array · 8 items

[0]

[1]

IKZF3

[2]

134

[3]

hsa-mir-6860

[4]

Down

[5]

SKI

[6]

210

[7]

hsa-mir-5100

[2] array · 8 items

[0]

[1]

TP53

[2]

130

[3]

hsa-mir-5703

[4]

Down

[5]

TNFRSF13C

[6]

136

[7]

hsa-mir-3197

[3] array · 8 items

[0]

[1]

IFNAR2

[2]

109

[3]

hsa-mir − 4510

[4]

Down

[5]

BCL2L11

[6]

122

[7]

hsa-mir-8064

[4] array · 8 items

[0]

[1]

SMAD5

[2]

[3]

hsa-mir-6086

[4]

Down

[5]

ICOSLG

[6]

119

[7]

hsa-mir-3672

[5] array · 8 items

[0]

[1]

STAT3

[2]

[3]

hsa-mir − 4270

[4]

Down

[5]

IL6R

[6]

[7]

hsa-mir-7641

[6] array · 8 items

[0]

[1]

TRAF6

[2]

[3]

hsa-mir-6745

[4]

Down

[5]

VCAM1

[6]

[7]

hsa-mir − 4270

[7] array · 8 items

[0]

[1]

RUNX1

[2]

[3]

hsa-mir − 4467

[4]

Down

[5]

LILRA2

[6]

[7]

hsa-mir − 4780

[8] array · 8 items

[0]

[1]

ABL1

[2]

[3]

hsa-mir − 4511

[4]

Down

[5]

IRAK4

[6]

[7]

hsa-mir-520e

[9] array · 8 items

[0]

[1]

KLRD1

[2]

[3]

hsa-mir-5094

[4]

Down

[5]

BTLA

[6]

[7]

hsa-mir-3133

[10] array · 8 items

[0]

[1]

CCL5

[2]

[3]

hsa-mir − 4775

[4]

Down

[5]

CD55

[6]

[7]

hsa-mir-6124

[11] array · 8 items

[0]

[1]

CTNNB1

[2]

[3]

hsa-mir − 4255

[4]

Down

[5]

CCL22

[6]

[7]

hsa-mir-5190

[12] array · 8 items

[0]

[1]

MAP4K2

[2]

[3]

hsa-mir-6131

[4]

Down

[5]

CD44

[6]

[7]

hsa-mir-5696

[13] array · 8 items

[0]

[1]

PSMB9

[2]

[3]

hsa-mir-3658

[4]

Down

[5]

PDGFB

[6]

[7]

hsa-mir-6132

[14] array · 8 items

[0]

[1]

ZBTB16

[2]

[3]

hsa-mir − 4287

[4]

Down

[5]

BCL2

[6]

[7]

hsa-mir-184

[15] array · 8 items

[0]

[1]

SOCS1

[2]

[3]

hsa-mir − 4495

[4]

Down

[5]

TFRC

[6]

[7]

hsa-mir-6070

[16] array · 8 items

[0]

[1]

HLA-A

[2]

[3]

hsa-mir-6129

[4]

Down

[5]

PIGR

[6]

[7]

hsa-mir − 4486

[17] array · 8 items

[0]

[1]

SERPING1

[2]

[3]

hsa-mir-1262

[4]

Down

[5]

CCL16

[6]

[7]

hsa-mir-7703

[18] array · 8 items

[0]

[1]

CCR5

[2]

[3]

hsa-mir-3183

[4]

Down

[5]

IFNAR1

[6]

[7]

hsa-mir − 4430

[19] array · 8 items

[0]

[1]

CLEC7A

[2]

[3]

hsa-mir − 4792

[4]

Down

[5]

TIRAP

[6]

[7]

hsa-mir − 4325

[20] array · 8 items

[0]

[1]

CD99

[2]

[3]

hsa-mir-3199

[4]

Down

[5]

ETS1

[6]

[7]

hsa-mir-3972

[21] array · 8 items

[0]

[1]

LILRB2

[2]

[3]

hsa-mir-3941

[4]

Down

[5]

CD59

[6]

[7]

hsa-mir-3919

[22] array · 8 items

[0]

[1]

ATG10

[2]

[3]

hsa-mir − 4309

[4]

Down

[5]

IKZF2

[6]

[7]

hsa-mir-5096

[23] array · 8 items

[0]

[1]

CCND3

[2]

[3]

hsa-mir-1321

[4]

Down

[5]

CEBPB

[6]

[7]

hsa-mir − 4510

[24] array · 8 items

[0]

[1]

STAT5B

[2]

[3]

hsa-mir-8485

[4]

Down

[5]

CD209

[6]

[7]

hsa-mir-3188

[25] array · 8 items

[0]

[1]

TRAF2

[2]

[3]

hsa-mir-6165

[4]

Down

[5]

HLA-C

[6]

[7]

hsa-mir − 4660

[26] array · 8 items

[0]

[1]

HRAS

[2]

[3]

hsa-mir-1268a

[4]

Down

[5]

DUSP4

[6]

[7]

hsa-mir-6089

[27] array · 8 items

[0]

[1]

STAT1

[2]

[3]

hsa-mir-1183

[4]

Down

[5]

CCR6

[6]

[7]

hsa-mir − 4539

[28] array · 8 items

[0]

[1]

JAK1

[2]

[3]

hsa-mir-107

[4]

Down

[5]

TGFBR1

[6]

[7]

hsa-mir-8083

[29] array · 8 items

[0]

[1]

CCRL2

[2]

[3]

hsa-mir − 4469

[4]

Down

[5]

MAPKAPK2

[6]

[7]

hsa-mir − 4468

[30] array · 8 items

[0]

[1]

ITGAL

[2]

[3]

hsa-mir-764

[4]

Down

[5]

SLC2A1

[6]

[7]

hsa-mir − 4448

[31] array · 8 items

[0]

[1]

FYN

[2]

[3]

hsa-mir-3924

[4]

Down

[5]

POU2F2

[6]

[7]

hsa-mir − 4307

[32] array · 8 items

[0]

[1]

JAK2

[2]

[3]

hsa-mir-5692a

[4]

Down

[5]

LIF

[6]

[7]

hsa-mir-3655

[33] array · 8 items

[0]

[1]

PDCD1

[2]

[3]

hsa-mir-922

[4]

Down

[5]

MBL2

[6]

[7]

hsa-mir-3689c

[34] array · 8 items

[0]

[1]

C1QBP

[2]

[3]

hsa-mir − 484

[4]

Down

[5]

HLA-B

[6]

[7]

hsa-mir-5047

[35] array · 8 items

[0]

[1]

IKBKB

[2]

[3]

hsa-mir − 451a

[4]

Down

[5]

ZEB1

[6]

[7]

hsa-mir-2113

[36] array · 8 items

[0]

[1]

TLR2

[2]

[3]

hsa-mir-105-5p

[4]

Down

[5]

RELA

[6]

[7]

hsa-mir-7515

[37] array · 8 items

[0]

[1]

XBP1

[2]

[3]

hsa-mir-320c

[4]

Down

[5]

CD46

[6]

[7]

hsa-mir − 4780

[38] array · 8 items

[0]

[1]

TMEM173

[2]

[3]

hsa-mir-5093

[4]

Down

[5]

PAX5

[6]

[7]

hsa-mir-6127

[39] array · 8 items

[0]

[1]

ATG5

[2]

[3]

hsa-mir-299-5p

[4]

Down

[5]

CASP3

[6]

[7]

hsa-mir − 4666b

[40] array · 8 items

[0]

[1]

ZAP70

[2]

[3]

hsa-mir-631

[4]

Down

[5]

STAT5A

[6]

[7]

hsa-mir − 4457

[41] array · 8 items

[0]

[1]

IFIH1

[2]

[3]

hsa-mir − 424-5p

[4]

Down

[5]

PTAFR

[6]

[7]

hsa-mir − 4301

[42] array · 8 items

[0]

[1]

KLRC1

[2]

[3]

hsa-mir-9-5p

[4]

Down

[5]

THY1

[6]

[7]

hsa-mir − 4269

[43] array · 8 items

[0]

[1]

IKZF1

[2]

[3]

hsa-mir-19a-3p

[4]

Down

[5]

ATG7

[6]

[7]

hsa-mir − 4518

[44] array · 8 items

[0]

[1]

KLRK1

[2]

[3]

hsa-mir-148b-3p

[4]

Down

[5]

S1PR1

[6]

[7]

hsa-mir-7977

[45] array · 8 items

[0]

[1]

IKBKE

[2]

[3]

hsa-mir-296-5p

[4]

Down

[5]

C8A

[6]

[7]

hsa-mir-1299

[46] array · 8 items

[0]

[1]

GFI1

[2]

[3]

hsa-mir-142-3p

[4]

Down

[5]

CDH5

[6]

[7]

hsa-mir-544a

[47] array · 8 items

[0]

[1]

NLRP3

[2]

[3]

hsa-mir-223-3p

[4]

Down

[5]

GPI

[6]

[7]

hsa-mir-760

[48] array · 8 items

[0]

[1]

ITGB2

[2]

[3]

hsa-mir-146a-5p

[4]

Down

[5]

ILF3

[6]

[7]

hsa-mir − 4314

[49] array · 8 items

[0]

[1]

IL18RAP

[2]

[3]

hsa-mir − 4677-3p

[4]

Down

[5]

KIT

[6]

[7]

hsa-mir − 4490

[50] array · 8 items

[0]

[1]

IRF7

[2]

[3]

hsa-mir-762

[4]

Down

[5]

GPR183

[6]

[7]

hsa-mir-1303

[51] array · 8 items

[0]

[1]

[2]

[3]

hsa-mir-335-5p

[4]

Down

[5]

TRAF3

[6]

[7]

hsa-mir-8085

[52] array · 8 items

[0]

[1]

MX1

[2]

[3]

hsa-mir-211-5p

[4]

Down

[5]

PTPN6

[6]

[7]

hsa-mir − 4525

[53] array · 8 items

[0]

[1]

CCR1

[2]

[3]

hsa-mir-181d-3p

[4]

Down

[5]

SELPLG

[6]

[7]

hsa-mir-1470

[54] array · 8 items

[0]

[1]

CUL9

[2]

[3]

hsa-mir-335-5p

[4]

Down

[5]

RAG1

[6]

[7]

hsa-mir-3666

[55] array · 8 items

[0]

[1]

IL18R1

[2]

[3]

hsa-mir-124-3p

[4]

Down

[5]

HLA-DRB1

[6]

[7]

hsa-mir-3978

[56] array · 8 items

[0]

[1]

GBP1

[2]

[3]

hsa-mir-124-3p

[4]

Down

[5]

TAL1

[6]

[7]

hsa-mir − 4719

[57] array · 8 items

[0]

[1]

TBX21

[2]

[3]

hsa-mir-29b-3p

[4]

Down

[5]

CCL11

[6]

[7]

hsa-mir-6077

[58] array · 8 items

[0]

[1]

GP1BB

[2]

[3]

hsa-mir-26b-5p

[4]

Down

[5]

IL6

[6]

[7]

hsa-mir − 451a

[59] array · 8 items

[0]

[1]

IRF5

[2]

[3]

hsa-mir-22-3p

[4]

Down

[5]

TGFBI

[6]

[7]

hsa-mir-1322

[60] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CTSS

[6]

[7]

hsa-mir-8066

[61] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CXCL12

[6]

[7]

hsa-mir-886-3p

[62] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

BID

[6]

[7]

hsa-mir-623

[63] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

TOLLIP

[6]

[7]

hsa-mir-6078

[64] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CD86

[6]

[7]

hsa-mir-8056

[65] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

TIGIT

[6]

[7]

hsa-mir-3941

[66] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CD3E

[6]

[7]

hsa-mir − 4510

[67] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

TNFRSF9

[6]

[7]

hsa-mir-1305

[68] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CXCR2

[6]

[7]

hsa-mir-588

[69] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

[6]

[7]

hsa-mir − 4310

[70] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL5

[6]

[7]

hsa-mir-604

[71] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

EBI3

[6]

[7]

hsa-mir-6069

[72] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

TCF4

[6]

[7]

hsa-let-7e-5p

[73] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

BCAP31

[6]

[7]

hsa-mir − 4514

[74] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CD82

[6]

[7]

hsa-mir-1470

[75] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

FCAR

[6]

[7]

hsa-mir-1976

[76] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

SELE

[6]

[7]

hsa-mir-630

[77] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

HLA-DRA

[6]

[7]

hsa-mir-3915

[78] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IFNB1

[6]

[7]

hsa-mir-6080

[79] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CD9

[6]

[7]

hsa-mir-5688

[80] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL10RA

[6]

[7]

hsa-mir-8064

[81] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL1RL2

[6]

[7]

hsa-mir − 4301

[82] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL1RAP

[6]

[7]

hsa-mir − 4635

[83] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL7

[6]

[7]

hsa-mir-203a-3p

[84] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CD19

[6]

[7]

hsa-mir − 466

[85] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IFNG

[6]

[7]

hsa-mir-15b-5p

[86] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

EGR2

[6]

[7]

hsa-mir-100-5p

[87] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

PTGER4

[6]

[7]

hsa-mir-101-3p

[88] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

C1S

[6]

[7]

hsa-mir-548 s

[89] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CX3CL1

[6]

[7]

hsa-mir-5093

[90] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CD244

[6]

[7]

hsa-mir-5702

[91] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

[6]

[7]

hsa-mir-1827

[92] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

PTK2

[6]

[7]

hsa-mir-543

[93] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

MS4A1

[6]

[7]

hsa-mir-644a

[94] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

AIRE

[6]

[7]

hsa-mir − 4770

[95] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

HLA-DOB

[6]

[7]

hsa-mir-1260a

[96] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

MAP4K4

[6]

[7]

hsa-mir-520e

[97] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

TRAF4

[6]

[7]

hsa-mir − 4284

[98] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

FN1

[6]

[7]

hsa-mir-200b-3p

[99] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

STAT6

[6]

[7]

hsa-mir-361-5p

[100] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CXCL11

[6]

[7]

hsa-mir − 4511

[101] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

EGR1

[6]

[7]

hsa-mir-377-3p

[102] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

C1R

[6]

[7]

hsa-mir-326

[103] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL10

[6]

[7]

hsa-mir-106a-5p

[104] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL12B

[6]

[7]

hsa-mir-103b

[105] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

PLAU

[6]

[7]

hsa-mir-23b-3p

[106] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

GATA3

[6]

[7]

hsa-mir-10b-5p

[107] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

FCGR2A

[6]

[7]

hsa-mir − 4275

[108] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

AICDA

[6]

[7]

hsa-mir-6873-3p

[109] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

NT5E

[6]

[7]

hsa-mir − 422a

[110] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CTLA4

[6]

[7]

hsa-mir-3924

[111] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

SPP1

[6]

[7]

hsa-mir-299-5p

[112] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

BTK

[6]

[7]

hsa-mir-1253

[113] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

MIF

[6]

[7]

hsa-mir-320a

[114] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL13

[6]

[7]

hsa-let-7i-5p

[115] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CD34

[6]

[7]

hsa-mir-106b-5p

[116] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL4

[6]

[7]

hsa-mir − 429

[117] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

RORC

[6]

[7]

hsa-mir-148b-3p

[118] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CTSC

[6]

[7]

hsa-mir-199a-5p

[119] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CD40

[6]

[7]

hsa-mir-503-5p

[120] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL2

[6]

[7]

hsa-mir-181c-5p

[121] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

TCF7

[6]

[7]

hsa-mir-22-3p

[122] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

ICAM5

[6]

[7]

hsa-mir − 4707-5p

[123] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CD83

[6]

[7]

hsa-mir-122-5p

[124] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

HLA-DQA1

[6]

[7]

hsa-mir − 4673

[125] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL4R

[6]

[7]

hsa-mir-331-3p

[126] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

MAPK11

[6]

[7]

hsa-let-7a-5p

[127] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

TNFSF12

[6]

[7]

hsa-mir-17-5p

[128] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CCL7

[6]

[7]

hsa-mir-135b-3p

[129] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL12A

[6]

[7]

hsa-mir-10a-5p

[130] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CSF1R

[6]

[7]

hsa-mir-155-5p

[131] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CFI

[6]

[7]

hsa-mir-181a-5p

[132] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL3

[6]

[7]

hsa-mir − 452-5p

[133] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

NFIL3

[6]

[7]

hsa-mir-183-5p

[134] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

ICAM3

[6]

[7]

hsa-mir-3943

[135] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

EOMES

[6]

[7]

hsa-mir-7855-5p

[136] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

PTPN22

[6]

[7]

hsa-mir-624-3p

[137] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

LGALS3

[6]

[7]

hsa-mir-744-5p

[138] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CCL19

[6]

[7]

hsa-mir-148b-3p

[139] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL17A

[6]

[7]

hsa-mir-16-1-3p

[140] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CD22

[6]

[7]

hsa-mir-19a-3p

[141] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CCL20

[6]

[7]

hsa-mir-21-5p

[142] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CCL26

[6]

[7]

hsa-mir-25-3p

[143] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

DEFB4A

[6]

[7]

hsa-mir-26b-5p

[144] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CXCR1

[6]

[7]

hsa-mir-335-5p

[145] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

MME

[6]

[7]

hsa-mir-1-3p

[146] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

VTN

[6]

[7]

hsa-mir-26b-5p

[147] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

LILRB5

[6]

[7]

hsa-mir-128-3p

[148] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL13RA1

[6]

[7]

hsa-mir-143-3p

[149] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

SIGIRR

[6]

[7]

hsa-mir-149-5p

[150] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

C14orf166

[6]

[7]

hsa-mir-331-3p

[151] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CD8A

[6]

[7]

hsa-mir-196b-5p

[152] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IRF8

[6]

[7]

hsa-mir-646

[153] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

FCGR2B

[6]

[7]

hsa-mir-18a-5p

[154] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

NOS2

[6]

[7]

hsa-mir-26a-5p

[155] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

RELB

[6]

[7]

hsa-mir-26b-5p

[156] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CXCL13

[6]

[7]

hsa-mir-26b-5p

[157] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

BATF3

[6]

[7]

hsa-mir-26b-5p

[158] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

ICAM4

[6]

[7]

hsa-mir-93-5p

[159] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL23A

[6]

[7]

hsa-mir-10a-5p

[160] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

ARHGDIB

[6]

[7]

hsa-mir-34a-5p

[161] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

LTA

[6]

[7]

hsa-mir-34a-5p

[162] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

ICAM2

[6]

[7]

hsa-mir-125b-5p

[163] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CR2

[6]

[7]

hsa-mir-132-3p

[164] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

B3GAT1

[6]

[7]

hsa-mir-132-3p

[165] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IDO1

[6]

[7]

hsa-mir-153-3p

[166] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

MASP1

[6]

[7]

hsa-mir-153-3p

[167] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CD80

[6]

[7]

hsa-mir-146a-5p

[168] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

HLA-DPA1

[6]

[7]

hsa-mir-155-5p

[169] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

TAGAP

[6]

[7]

hsa-mir-374a-5p

[170] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CD79A

[6]

[7]

hsa-mir-335-5p

[171] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

FCGRT

[6]

[7]

hsa-mir-335-5p

[172] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

HLA-DMA

[6]

[7]

hsa-mir-335-5p

[173] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

KLRB1

[6]

[7]

hsa-mir-335-5p

[174] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

LCK

[6]

[7]

hsa-mir-335-5p

[175] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

PPBP

[6]

[7]

hsa-mir-335-5p

[176] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CCL15

[6]

[7]

hsa-mir-335-5p

[177] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CCL24

[6]

[7]

hsa-mir-335-5p

[178] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

LILRA1

[6]

[7]

hsa-mir-335-5p

[179] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

LILRA3

[6]

[7]

hsa-mir-335-5p

[180] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

PLA2G2E

[6]

[7]

hsa-mir-335-5p

[181] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL22

[6]

[7]

hsa-mir-335-5p

[182] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL27

[6]

[7]

hsa-mir-335-5p

[183] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

MBP

[6]

[7]

hsa-mir-127-5p

[184] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL20

[6]

[7]

hsa-mir-624-3p

row_count

185

column_count

numeric_cells

540

header_rows

locator

section[16]/table-wrap[1]#Tab7

[9] object · 16 fields

asset:table:pmid:33251083:8

role

table

format

jats-table

media_type

application/vnd.jats.table+json

uri

null

sha256

sha256:fc7eead614710882690059e1d793e3977d8f342b2ee037055408615b89dca16d

bytes

4208

access

open

state

verified

reader

read_table

reader_status

available

identifier

section[17]/table-wrap[1]#Tab8

version

null

note

TF—target gene interaction table

structure object · 5 fields

pmcid

PMC7679428

section_index

section_title

Construction of target gene–TF regulatory network

row_count

column_count

table object · 8 fields

label

Table 8

caption

TF—target gene interaction table

rows array · 75 items

[0] array · 8 items

[0]

Regulation

[1]

[2]

Degree

[3]

Target Gene

[4]

Regulation

[5]

[6]

Degree

[7]

Target Gene

[1] array · 8 items

[0]

[1]

FOXC1

[2]

[3]

JAK1

[4]

Down

[5]

FOXC1

[6]

127

[7]

KLRF2

[2] array · 8 items

[0]

[1]

GATA2

[2]

[3]

TRAF6

[4]

Down

[5]

GATA2

[6]

102

[7]

CD1A

[3] array · 8 items

[0]

[1]

YY1

[2]

[3]

CLEC7A

[4]

Down

[5]

YY1

[6]

[7]

TNFRSF4

[4] array · 8 items

[0]

[1]

CREB1

[2]

[3]

STAT1

[4]

Down

[5]

FOXL1

[6]

[7]

MME

[5] array · 8 items

[0]

[1]

TFAP2A

[2]

[3]

IKZF1

[4]

Down

[5]

NFKB1

[6]

[7]

CXCL12

[6] array · 8 items

[0]

[1]

PPARG

[2]

[3]

IRF7

[4]

Down

[5]

USF2

[6]

[7]

DEFB1

[7] array · 8 items

[0]

[1]

NFKB1

[2]

[3]

TRAF2

[4]

Down

[5]

SRF

[6]

[7]

STAT5A

[8] array · 8 items

[0]

[1]

E2F1

[2]

[3]

PSMB9

[4]

Down

[5]

CREB1

[6]

[7]

TNFRSF10C

[9] array · 8 items

[0]

[1]

RELA

[2]

[3]

IFI35

[4]

Down

[5]

TP53

[6]

[7]

C1S

[10] array · 8 items

[0]

[1]

USF2

[2]

[3]

LTB4R

[4]

Down

[5]

STAT3

[6]

[7]

IL26

[11] array · 8 items

[0]

[1]

SREBF1

[2]

[3]

CCND3

[4]

Down

[5]

PPARG

[6]

[7]

ICAM4

[12] array · 8 items

[0]

[1]

HINFP

[2]

[3]

GP1BB

[4]

Down

[5]

JUN

[6]

[7]

FCGRT

[13] array · 8 items

[0]

[1]

JUN

[2]

[3]

TLR2

[4]

Down

[5]

E2F1

[6]

[7]

GATA3

[14] array · 8 items

[0]

[1]

FOXL1

[2]

[3]

LCP2

[4]

Down

[5]

HINFP

[6]

[7]

BCL2L11

[15] array · 8 items

[0]

[1]

BRCA1

[2]

[3]

CD99

[4]

Down

[5]

TFAP2A

[6]

[7]

EOMES

[16] array · 8 items

[0]

[1]

NFIC

[2]

[3]

FYN

[4]

Down

[5]

NFIC

[6]

[7]

IFNA2

[17] array · 8 items

[0]

[1]

SRF

[2]

[3]

IL18RAP

[4]

Down

[5]

MEF2A

[6]

[7]

CTSS

[18] array · 8 items

[0]

[1]

GATA3

[2]

[3]

CX3CR1

[4]

Down

[5]

NFYA

[6]

[7]

GPI

[19] array · 8 items

[0]

[1]

PRDM1

[2]

[3]

GNLY

[4]

Down

[5]

TEAD1

[6]

[7]

LTA

[20] array · 8 items

[0]

[1]

POU2F2

[2]

[3]

SLAMF7

[4]

Down

[5]

HOXA5

[6]

[7]

PPBP

[21] array · 8 items

[0]

[1]

USF1

[2]

[3]

ATG5

[4]

Down

[5]

MAX

[6]

[7]

IL12B

[22] array · 8 items

[0]

[1]

FOS

[2]

[3]

CCL5

[4]

Down

[5]

SREBF2

[6]

[7]

CD80

[23] array · 8 items

[0]

[1]

TEAD1

[2]

[3]

CCR1

[4]

Down

[5]

SREBF1

[6]

[7]

DEFB4A

[24] array · 8 items

[0]

[1]

TFAP2C

[2]

[3]

CEACAM1

[4]

Down

[5]

JUND

[6]

[7]

HLA-DPB1

[25] array · 8 items

[0]

[1]

ELK4

[2]

[3]

GBP1

[4]

Down

[5]

TFAP2C

[6]

[7]

HLA-DQA1

[26] array · 8 items

[0]

[1]

HOXA5

[2]

[3]

GZMB

[4]

Down

[5]

RUNX2

[6]

[7]

C1R

[27] array · 8 items

[0]

[1]

E2F6

[2]

[3]

HRAS

[4]

Down

[5]

ARID3A

[6]

[7]

SKI

[28] array · 8 items

[0]

[1]

HNF4A

[2]

[3]

IFNAR2

[4]

Down

[5]

HNF4A

[6]

[7]

CR2

[29] array · 8 items

[0]

[1]

RUNX2

[2]

[3]

KLRK1

[4]

Down

[5]

ZNF354C

[6]

[7]

C8A

[30] array · 8 items

[0]

[1]

NFYA

[2]

[3]

ATG10

[4]

Down

[5]

NR3C1

[6]

[7]

FCGR2B

[31] array · 8 items

[0]

[1]

SREBF2

[2]

[3]

C1QBP

[4]

Down

[5]

IRF2

[6]

[7]

XCR1

[32] array · 8 items

[0]

[1]

MAX

[2]

[3]

CCRL2

[4]

Down

[5]

PRDM1

[6]

[7]

IL13

[33] array · 8 items

[0]

[1]

CEBPB

[2]

[3]

CD247

[4]

Down

[5]

FOS

[6]

[7]

CCL15

[34] array · 8 items

[0]

[1]

PRRX2

[2]

[3]

CTNNB1

[4]

Down

[5]

USF1

[6]

[7]

IRAK4

[35] array · 8 items

[0]

[1]

ZNF354C

[2]

[3]

GFI1

[4]

Down

[5]

FOXA1

[6]

[7]

ITLN1

[36] array · 8 items

[0]

[1]

MEF2A

[2]

[3]

IL18R1

[4]

Down

[5]

PRRX2

[6]

[7]

TLR9

[37] array · 8 items

[0]

[1]

ARID3A

[2]

[3]

ABL1

[4]

Down

[5]

STAT1

[6]

[7]

LCK

[38] array · 8 items

[0]

[1]

ESR1

[2]

[3]

[4]

Down

[5]

SP1

[6]

[7]

CD82

[39] array · 8 items

[0]

[1]

PDX1

[2]

[3]

HLA-A

[4]

Down

[5]

ELK4

[6]

[7]

PAX5

[40] array · 8 items

[0]

[1]

NR3C1

[2]

[3]

ITGAL

[4]

Down

[5]

NKX3-2

[6]

[7]

PLA2G2E

[41] array · 8 items

[0]

[1]

KLF5

[2]

[3]

ITGB2

[4]

Down

[5]

KLF5

[6]

[7]

ICOSLG

[42] array · 8 items

[0]

[1]

ELK1

[2]

[3]

JAK2

[4]

Down

[5]

ELK1

[6]

[7]

IDO1

[43] array · 8 items

[0]

[1]

SP1

[2]

[3]

MAP4K2

[4]

Down

[5]

BRCA1

[6]

[7]

LGALS3

[44] array · 8 items

[0]

[1]

EGR1

[2]

[3]

MX1

[4]

Down

[5]

ESR1

[6]

[7]

MASP2

[45] array · 8 items

[0]

[1]

EN1

[2]

[3]

SMAD5

[4]

Down

[5]

TP63

[6]

[7]

CD19

[46] array · 8 items

[0]

[1]

IRF2

[2]

[3]

RUNX1

[4]

Down

[5]

PAX2

[6]

[7]

CD48

[47] array · 8 items

[0]

[1]

PAX2

[2]

[3]

STAT5B

[4]

Down

[5]

NR2F1

[6]

[7]

CEBPB

[48] array · 8 items

[0]

[1]

NR2F1

[2]

[3]

CUL9

[4]

Down

[5]

E2F6

[6]

[7]

CD8A

[49] array · 8 items

[0]

[1]

FOXF2

[2]

[3]

IKBKE

[4]

Down

[5]

EN1

[6]

[7]

IL22

[50] array · 8 items

[0]

[1]

TP63

[2]

[3]

IKZF3

[4]

Down

[5]

SPIB

[6]

[7]

PTAFR

[51] array · 8 items

[0]

[1]

FOXA1

[2]

[3]

IL2RG

[4]

Down

[5]

FOXF2

[6]

[7]

SELE

[52] array · 8 items

[0]

[1]

NRF1

[2]

[3]

MAP4K1

[4]

Down

[5]

SOX10

[6]

[7]

POU2F2

[53] array · 8 items

[0]

[1]

JUND

[2]

[3]

NLRP3

[4]

Down

[5]

SRY

[6]

[7]

EDNRB

[54] array · 8 items

[0]

[1]

SPIB

[2]

[3]

ZBTB16

[4]

Down

[5]

NRF1

[6]

[7]

IFNAR1

[55] array · 8 items

[0]

[1]

REL

[2]

[3]

IKZF3

[4]

Down

[5]

SOX17

[6]

[7]

TNFRSF14

[56] array · 8 items

[0]

[1]

NKX3-1

[2]

[3]

IRF5

[4]

Down

[5]

SOX5

[6]

[7]

BTK

[57] array · 8 items

[0]

[1]

SOX5

[2]

[3]

KLRD1

[4]

Down

[5]

NKX2-5

[6]

[7]

PIGR

[58] array · 8 items

[0]

[1]

SOX10

[2]

[3]

STAT3

[4]

Down

[5]

ELF5

[6]

[7]

BATF3

[59] array · 8 items

[0]

[1]

MYB

[2]

[3]

JAK2

[4]

Down

[5]

NFATC2

[6]

[7]

IL4

[60] array · 8 items

[0]

[1]

SRY

[2]

[3]

KLRK1

[4]

Down

[5]

PDX1

[6]

[7]

ITGAE

[61] array · 8 items

[0]

[1]

ELF5

[2]

[3]

TLR2

[4]

Down

[5]

NFYB

[6]

[7]

PTPN6

[62] array · 8 items

[0]

[1]

NFIL3

[2]

[3]

CX3CR1

[4]

Down

[5]

ZFX

[6]

[7]

THY1

[63] array · 8 items

[0]

[1]

NR4A2

[2]

[3]

[4]

Down

[5]

NR4A2

[6]

[7]

CSF2

[64] array · 8 items

[0]

[1]

FEV

[2]

[3]

ATG5

[4]

Down

[5]

FEV

[6]

[7]

IL23A

[65] array · 8 items

[0]

[1]

FOXI1

[2]

[3]

CCL5

[4]

Down

[5]

MYB

[6]

[7]

MIF

[66] array · 8 items

[0]

[1]

NKX3-2

[2]

[3]

GZMB

[4]

Down

[5]

HNF1B

[6]

[7]

SPP1

[67] array · 8 items

[0]

[1]

E2F4

[2]

[3]

IKZF1

[4]

Down

[5]

REL

[6]

[7]

STAT6

[68] array · 8 items

[0]

[1]

TFCP2L1

[2]

[3]

LCP2

[4]

Down

[5]

ESR2

[6]

[7]

CCL22

[69] array · 8 items

[0]

[1]

NR2E3

[2]

[3]

HLA-A

[4]

Down

[5]

FOXI1

[6]

[7]

CD209

[70] array · 8 items

[0]

[1]

GATA1

[2]

[3]

HLA-A

[4]

Down

[5]

FOXD1

[6]

[7]

HLA-DOB

[71] array · 8 items

[0]

[1]

HNF1B

[2]

[3]

IL18R1

[4]

Down

[5]

ESRRB

[6]

[7]

ICAM2

[72] array · 8 items

[0]

[1]

SOX17

[2]

[3]

LILRA6

[4]

Down

[5]

NR2E3

[6]

[7]

IL2

[73] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

E2F4

[6]

[7]

S1PR1

[74] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

GATA1

[6]

[7]

PDGFB

row_count

column_count

numeric_cells

183

header_rows

locator

section[17]/table-wrap[1]#Tab8

[10] object · 16 fields

asset:table:pmid:33251083:9

role

table

format

jats-table

media_type

application/vnd.jats.table+json

uri

null

sha256

sha256:ab2eb6a7044b00eb51c3c4e6fc432d9d6c9edd8c43fbcf05a2e22a783d99f064

bytes

32962

access

open

state

verified

reader

read_table

reader_status

available

identifier

section[12]/table-wrap[1]#Tab1

version

null

note

The statistical metrics for key differentially expressed genes (DEGs)

structure object · 5 fields

pmcid

PMC7679428

section_index

section_title

Identification of DEGs

row_count

325

column_count

table object · 8 fields

label

Table 1

caption

The statistical metrics for key differentially expressed genes (DEGs)

rows array · 325 items

[0] array · 7 items

[0]

Gene Symbol

[1]

logFC

[2]

pValue

[3]

adj.P.Val

[4]

t value

[5]

Regulation

[6]

Gene Name

[1] array · 7 items

[0]

JAK1

[1]

0.641818

[2]

1.84E − 11

[3]

1.84E − 11

[4]

9.973193

[5]

[6]

Janus kinase 1

[2] array · 7 items

[0]

ZAP70

[1]

0.810545

[2]

2.91E − 10

[3]

2.91E − 10

[4]

8.897328

[5]

[6]

Zeta chain of T cell receptor associated protein kinase 70

[3] array · 7 items

[0]

CCR5

[1]

1.239182

[2]

3.04E − 10

[3]

3.04E − 10

[4]

8.880753

[5]

[6]

C–C motif chemokine receptor 5 (gene/pseudogene)

[4] array · 7 items

[0]

CTNNB1

[1]

0.633545

[2]

4.11E − 10

[3]

4.11E − 10

[4]

8.766907

[5]

[6]

Catenin beta 1

[5] array · 7 items

[0]

TRAF6

[1]

0.644773

[2]

7.11E − 10

[3]

7.11E − 10

[4]

8.561082

[5]

[6]

TNF receptor associated factor 6

[6] array · 7 items

[0]

FYN

[1]

0.536182

[2]

1.96E − 08

[3]

1.96E − 08

[4]

7.357891

[5]

[6]

FYN proto-oncogene, Src family tyrosine kinase

[7] array · 7 items

[0]

HRAS

[1]

0.668773

[2]

2.14E − 08

[3]

2.14E − 08

[4]

7.325507

[5]

[6]

HRas proto-oncogene, GTPase

[8] array · 7 items

[0]

ITGB2

[1]

0.805182

[2]

2.8E − 06

[3]

2.8E − 06

[4]

5.644273

[5]

[6]

Integrin subunit beta 2

[9] array · 7 items

[0]

ZBTB16

[1]

1.099955

[2]

3.88E − 06

[3]

3.88E − 06

[4]

5.53388

[5]

[6]

Zinc finger and BTB domain containing 16

[10] array · 7 items

[0]

ABL1

[1]

0.468091

[2]

4.46E − 06

[3]

4.46E − 06

[4]

5.486138

[5]

[6]

ABL proto-oncogene 1, non-receptor tyrosine kinase

[11] array · 7 items

[0]

CX3CR1

[1]

0.834227

[2]

6.3E − 06

[3]

6.3E − 06

[4]

5.369313

[5]

[6]

C-X3-C motif chemokine receptor 1

[12] array · 7 items

[0]

PDCD1

[1]

0.880955

[2]

7.79E − 06

[3]

7.79E − 06

[4]

5.297093

[5]

[6]

Programmed cell death 1

[13] array · 7 items

[0]

IRF5

[1]

0.884364

[2]

1.56E − 05

[3]

1.56E − 05

[4]

5.062275

[5]

[6]

Interferon regulatory factor 5

[14] array · 7 items

[0]

IL2RG

[1]

0.590818

[2]

1.7E − 05

[3]

1.7E − 05

[4]

5.032467

[5]

[6]

Interleukin 2 receptor subunit gamma

[15] array · 7 items

[0]

IKZF3

[1]

0.467273

[2]

1.78E − 0E − 05

[3]

1.78E − 05

[4]

5.016592

[5]

[6]

IKAROS family zinc finger 3

[16] array · 7 items

[0]

CCR1

[1]

1.613727

[2]

2.3E − 05

[3]

2.3E − 05

[4]

4.929543

[5]

[6]

C–C motif chemokine receptor 1

[17] array · 7 items

[0]

CD99

[1]

0.398773

[2]

4.76E − 05

[3]

4.76E − 05

[4]

4.681138

[5]

[6]

CD99 molecule (Xg blood group)

[18] array · 7 items

[0]

SMAD5

[1]

0.349818

[2]

5.02E − 05

[3]

5.02E − 05

[4]

4.662446

[5]

[6]

SMAD family member 5

[19] array · 7 items

[0]

CD247

[1]

0.51

[2]

5.34E − 05

[3]

5.34E − 05

[4]

4.641555

[5]

[6]

CD247 molecule

[20] array · 7 items

[0]

TP53

[1]

0.372273

[2]

5.85E − 05

[3]

5.85E − 05

[4]

4.609909

[5]

[6]

Tumor protein p53

[21] array · 7 items

[0]

LAG3

[1]

0.988591

[2]

6.64E − 05

[3]

6.64E − 05

[4]

4.566916

[5]

[6]

Lymphocyte activating 3

[22] array · 7 items

[0]

LCP2

[1]

0.432682

[2]

6.74E − 05

[3]

6.74E − 05

[4]

4.561553

[5]

[6]

Lymphocyte cytosolic protein 2

[23] array · 7 items

[0]

SLAMF7

[1]

0.577409

[2]

8.58E − 05

[3]

8.58E − 05

[4]

4.478485

[5]

[6]

SLAM family member 7

[24] array · 7 items

[0]

TMEM173

[1]

0.377318

[2]

0.000103

[3]

0.000103

[4]

4.416144

[5]

[6]

Transmembrane protein 173

[25] array · 7 items

[0]

CUL9

[1]

0.4155

[2]

0.000119

[3]

0.000119

[4]

4.366647

[5]

[6]

Cullin 9

[26] array · 7 items

[0]

[1]

1.280182

[2]

0.000153

[3]

0.000153

[4]

4.279415

[5]

[6]

Complement C2

[27] array · 7 items

[0]

GNLY

[1]

1.067364

[2]

0.000167

[3]

0.000167

[4]

4.248083

[5]

[6]

Granulysin

[28] array · 7 items

[0]

ATG10

[1]

0.490955

[2]

0.000234

[3]

0.000234

[4]

4.130655

[5]

[6]

Autophagy related 10

[29] array · 7 items

[0]

IKZF1

[1]

0.321682

[2]

0.000285

[3]

0.000285

[4]

4.061503

[5]

[6]

IKAROS family zinc finger 1

[30] array · 7 items

[0]

KIR_Activating_Subgroup_2

[1]

1.279318

[2]

0.00043

[3]

0.00043

[4]

3.915229

[5]

[6]

Killer-cell immunoglobulin-like receptorSubgroup 2

[31] array · 7 items

[0]

ITGAL

[1]

0.370273

[2]

0.000461

[3]

0.000461

[4]

3.890576

[5]

[6]

Integrin subunit alpha L

[32] array · 7 items

[0]

SERPING1

[1]

1.992773

[2]

0.00057

[3]

0.00057

[4]

3.815201

[5]

[6]

Serpin family G member 1

[33] array · 7 items

[0]

STAT1

[1]

1.066864

[2]

0.000762

[3]

0.000762

[4]

3.711251

[5]

[6]

signal transducer and activator of transcription 1

[34] array · 7 items

[0]

CCRL2

[1]

0.621773

[2]

0.000844

[3]

0.000844

[4]

3.674266

[5]

[6]

C–C motif chemokine receptor like 2

[35] array · 7 items

[0]

RUNX1

[1]

0.392409

[2]

0.001035

[3]

0.001035

[4]

3.600334

[5]

[6]

RUNX family transcription factor 1

[36] array · 7 items

[0]

KIR_Activating_Subgroup_1

[1]

1.243455

[2]

0.001444

[3]

0.001444

[4]

3.478418

[5]

[6]

Killer-cell immunoglobulin-like receptor Subgroup 1

[37] array · 7 items

[0]

IFIH1

[1]

1.189

[2]

0.001492

[3]

0.001492

[4]

3.466339

[5]

[6]

Interferon induced with helicase C domain 1

[38] array · 7 items

[0]

GP1BB

[1]

1.252364

[2]

0.001517

[3]

0.001517

[4]

3.460324

[5]

[6]

Glycoprotein Ib platelet subunit beta

[39] array · 7 items

[0]

TBX21

[1]

0.557591

[2]

0.001716

[3]

0.001716

[4]

3.414736

[5]

[6]

T-box transcription factor 21

[40] array · 7 items

[0]

BST2

[1]

0.825727

[2]

0.00183

[3]

0.00183

[4]

3.390875

[5]

[6]

Bone marrow stromal cell antigen 2

[41] array · 7 items

[0]

JAK2

[1]

0.436727

[2]

0.001927

[3]

0.001927

[4]

3.371677

[5]

[6]

Janus kinase 2

[42] array · 7 items

[0]

PSMB9

[1]

0.490864

[2]

0.001928

[3]

0.001928

[4]

3.371431

[5]

[6]

Proteasome 20S subunit beta 9

[43] array · 7 items

[0]

XBP1

[1]

0.485455

[2]

0.002051

[3]

0.002051

[4]

3.348399

[5]

[6]

X-box binding protein 1

[44] array · 7 items

[0]

GBP1

[1]

0.999545

[2]

0.003627

[3]

0.003627

[4]

3.133218

[5]

[6]

Guanylate binding protein 1

[45] array · 7 items

[0]

STAT4

[1]

0.295591

[2]

0.003667

[3]

0.003667

[4]

3.129061

[5]

[6]

Signal transducer and activator of transcription 4

[46] array · 7 items

[0]

MAP4K1

[1]

0.2385

[2]

0.003959

[3]

0.003959

[4]

3.099644

[5]

[6]

Mitogen-activated protein kinase kinasekinasekinase 1

[47] array · 7 items

[0]

CCND3

[1]

0.326591

[2]

0.004076

[3]

0.004076

[4]

3.08846

[5]

[6]

cyclin D3

[48] array · 7 items

[0]

LILRA6

[1]

0.817091

[2]

0.004839

[3]

0.004839

[4]

3.022071

[5]

[6]

Leukocyte immunoglobulin like receptor A6

[49] array · 7 items

[0]

GFI1

[1]

0.495591

[2]

0.005741

[3]

0.005741

[4]

2.955427

[5]

[6]

Growth factor independent 1 transcriptional repressor

[50] array · 7 items

[0]

HLA-A

[1]

0.385909

[2]

0.005824

[3]

0.005824

[4]

2.949825

[5]

[6]

Major histocompatibility complex, class I, A

[51] array · 7 items

[0]

IL18RAP

[1]

0.982227

[2]

0.006135

[3]

0.006135

[4]

2.929331

[5]

[6]

Interleukin 18 receptor accessory protein

[52] array · 7 items

[0]

C1QBP

[1]

0.264182

[2]

0.006145

[3]

0.006145

[4]

2.928686

[5]

[6]

Complement C1q binding protein

[53] array · 7 items

[0]

CCL5

[1]

0.3105

[2]

0.006563

[3]

0.006563

[4]

2.902767

[5]

[6]

C–C motif chemokine ligand 5

[54] array · 7 items

[0]

SOCS1

[1]

0.704318

[2]

0.007115

[3]

0.007115

[4]

2.870801

[5]

[6]

Suppressor of cytokine signaling 1

[55] array · 7 items

[0]

STAT3

[1]

0.370545

[2]

0.010179

[3]

0.010179

[4]

2.72698

[5]

[6]

Signal transducer and activator of transcription 3

[56] array · 7 items

[0]

CEACAM1

[1]

0.784909

[2]

0.011682

[3]

0.011682

[4]

2.670737

[5]

[6]

CEA cell adhesion molecule 1

[57] array · 7 items

[0]

TLR2

[1]

0.589773

[2]

0.013287

[3]

0.013287

[4]

2.617647

[5]

[6]

toll like receptor 2

[58] array · 7 items

[0]

KLRK1

[1]

0.358136

[2]

0.014239

[3]

0.014239

[4]

2.588898

[5]

[6]

killer cell lectin like receptor K1

[59] array · 7 items

[0]

MAP4K2

[1]

0.221227

[2]

0.018828

[3]

0.018828

[4]

2.471244

[5]

[6]

Mitogen-activated protein kinase kinasekinasekinase 2

[60] array · 7 items

[0]

KLRC1

[1]

0.7945

[2]

0.019896

[3]

0.019896

[4]

2.4477

[5]

[6]

Killer cell lectin like receptor C1

[61] array · 7 items

[0]

ATG5

[1]

0.327

[2]

0.020137

[3]

0.020137

[4]

2.44253

[5]

[6]

Autophagy related 5

[62] array · 7 items

[0]

IL18R1

[1]

0.713136

[2]

0.020905

[3]

0.020905

[4]

2.426467

[5]

[6]

Interleukin 18 receptor 1

[63] array · 7 items

[0]

IKBKB

[1]

0.1695

[2]

0.027641

[3]

0.027641

[4]

2.304841

[5]

[6]

Inhibitor of nuclear factor kappa B kinase subunit beta

[64] array · 7 items

[0]

STAT5B

[1]

0.2575

[2]

0.032278

[3]

0.032278

[4]

2.235871

[5]

[6]

Signal transducer and activator of transcription 5B

[65] array · 7 items

[0]

MX1

[1]

1.111727

[2]

0.032817

[3]

0.032817

[4]

2.228441

[5]

[6]

MX dynamin like GTPase 1

[66] array · 7 items

[0]

IRF7

[1]

0.898909

[2]

0.033248

[3]

0.033248

[4]

2.222589

[5]

[6]

Interferon regulatory factor 7

[67] array · 7 items

[0]

TRAF2

[1]

0.171955

[2]

0.034273

[3]

0.034273

[4]

2.208908

[5]

[6]

TNF receptor associated factor 2

[68] array · 7 items

[0]

IFI35

[1]

0.725909

[2]

0.035093

[3]

0.035093

[4]

2.198229

[5]

[6]

Interferon induced protein 35

[69] array · 7 items

[0]

IKBKE

[1]

0.236545

[2]

0.035149

[3]

0.035149

[4]

2.197514

[5]

[6]

Inhibitor of nuclear factor kappa B kinase subunit epsilon

[70] array · 7 items

[0]

CLEC7A

[1]

0.421227

[2]

0.037828

[3]

0.037828

[4]

2.164155

[5]

[6]

C-type lectin domain containing 7A

[71] array · 7 items

[0]

LTB4R

[1]

0.465227

[2]

0.03902

[3]

0.03902

[4]

2.149988

[5]

[6]

Leukotriene B4 receptor

[72] array · 7 items

[0]

GZMB

[1]

0.437364

[2]

0.040654

[3]

0.040654

[4]

2.131179

[5]

[6]

Granzyme B

[73] array · 7 items

[0]

NLRP3

[1]

0.290364

[2]

0.04286

[3]

0.04286

[4]

2.106829

[5]

[6]

NLR family pyrin domain containing 3

[74] array · 7 items

[0]

LILRB2

[1]

0.299364

[2]

0.042931

[3]

0.042931

[4]

2.106059

[5]

[6]

Leukocyte immunoglobulin like receptor B2

[75] array · 7 items

[0]

IFNAR2

[1]

0.184136

[2]

0.048633

[3]

0.048633

[4]

2.047965

[5]

[6]

Interferon alpha and beta receptor subunit 2

[76] array · 7 items

[0]

KLRD1

[1]

0.4455

[2]

0.049759

[3]

0.049759

[4]

2.037205

[5]

[6]

Killer cell lectin like receptor D1

[77] array · 7 items

[0]

CD19

[1]

− 1.7175

[2]

5.18E − 16

[3]

5.18E − 16

[4]

− 14.7177

[5]

Down

[6]

CD19 molecule

[78] array · 7 items

[0]

CD22

[1]

− 1.757

[2]

4.93E − 15

[3]

4.93E − 15

[4]

− 13.592

[5]

Down

[6]

CD22 molecule

[79] array · 7 items

[0]

MS4A1

[1]

− 1.67741

[2]

1.67E − 14

[3]

1.67E − 14

[4]

− 13.0082

[5]

Down

[6]

Membrane spanning 4-domains A1

[80] array · 7 items

[0]

CD45RB

[1]

− 0.94709

[2]

4.17E − 14

[3]

4.17E − 14

[4]

− 12.5832

[5]

Down

[6]

Receptor-Type Tyrosine-Protein Phosphatase C

[81] array · 7 items

[0]

IL6R

[1]

− 2.0375

[2]

1.05E − 13

[3]

1.05E − 13

[4]

− 12.164

[5]

Down

[6]

interleukin 6 receptor

[82] array · 7 items

[0]

TNFRSF13C

[1]

− 1.46186

[2]

2.18E − 13

[3]

2.18E − 13

[4]

− 11.8375

[5]

Down

[6]

TNF receptor superfamily member 13C

[83] array · 7 items

[0]

PAX5

[1]

− 1.37636

[2]

2.92E − 13

[3]

2.92E − 13

[4]

− 11.7085

[5]

Down

[6]

Paired box 5

[84] array · 7 items

[0]

CD79A

[1]

− 1.29577

[2]

2.53E − 12

[3]

2.53E − 12

[4]

− 10.7841

[5]

Down

[6]

CD79a molecule

[85] array · 7 items

[0]

ARHGDIB

[1]

− 0.65064

[2]

3.68E − 12

[3]

3.68E − 12

[4]

− 10.6278

[5]

Down

[6]

Rho GDP dissociation inhibitor beta

[86] array · 7 items

[0]

HLA-DQB1

[1]

− 4.88305

[2]

5.18E − 12

[3]

5.18E − 12

[4]

− 10.4865

[5]

Down

[6]

Major histocompatibility complex, class II, DQ beta 1

[87] array · 7 items

[0]

HLA-DQA1

[1]

− 6.1155

[2]

1.8E − 11

[3]

1.8E − 11

[4]

− 9.98021

[5]

Down

[6]

Major histocompatibility complex, class II, DQ alpha 1

[88] array · 7 items

[0]

MAPKAPK2

[1]

− 0.99755

[2]

5.49E − 11

[3]

5.49E − 11

[4]

− 9.53915

[5]

Down

[6]

MAPK activated protein kinase 2

[89] array · 7 items

[0]

SLAMF6

[1]

− 0.87414

[2]

2.16E − 10

[3]

2.16E − 10

[4]

− 9.01008

[5]

Down

[6]

SLAM family member 6

[90] array · 7 items

[0]

PTGER4

[1]

− 0.76932

[2]

2.43E − 10

[3]

2.43E − 10

[4]

− 8.96519

[5]

Down

[6]

Prostaglandin E receptor 4

[91] array · 7 items

[0]

CD79B

[1]

− 0.84082

[2]

2.75E − 10

[3]

2.75E − 10

[4]

− 8.91788

[5]

Down

[6]

CD79b molecule

[92] array · 7 items

[0]

CD97

[1]

− 1.1985

[2]

3.22E − 10

[3]

3.22E − 10

[4]

− 8.85915

[5]

Down

[6]

Leukocyte antigen CD97

[93] array · 7 items

[0]

IL1RL2

[1]

− 1.04873

[2]

3.57E − 10

[3]

3.57E − 10

[4]

− 8.81964

[5]

Down

[6]

Interleukin 1 receptor like 2

[94] array · 7 items

[0]

CD1A

[1]

− 1.07114

[2]

3.6E − 10

[3]

3.6E − 10

[4]

− 8.81626

[5]

Down

[6]

CD1a molecule

[95] array · 7 items

[0]

IL1RAP

[1]

− 1.43418

[2]

8.92E − 10

[3]

8.92E − 10

[4]

− 8.47672

[5]

Down

[6]

Interleukin 1 receptor accessory protein

[96] array · 7 items

[0]

TNFSF12

[1]

− 0.53718

[2]

2.42E − 09

[3]

2.42E − 09

[4]

− 8.10915

[5]

Down

[6]

TNF superfamily member 12

[97] array · 7 items

[0]

AICDA

[1]

− 0.94759

[2]

2.89E − 09

[3]

2.89E − 09

[4]

− 8.04473

[5]

Down

[6]

Activation induced cytidinedeaminase

[98] array · 7 items

[0]

MBP

[1]

− 0.77614

[2]

4.02E − 09

[3]

4.02E − 09

[4]

− 7.92468

[5]

Down

[6]

myelin basic protein

[99] array · 7 items

[0]

TRAF4

[1]

− 0.67777

[2]

5.69E − 09

[3]

5.69E − 09

[4]

− 7.79888

[5]

Down

[6]

TNF receptor associated factor 4

[100] array · 7 items

[0]

MIF

[1]

− 0.59309

[2]

5.94E − 09

[3]

5.94E − 09

[4]

− 7.78344

[5]

Down

[6]

Macrophage migration inhibitory factor

[101] array · 7 items

[0]

CCBP2

[1]

− 1.34027

[2]

6.31E − 09

[3]

6.31E − 09

[4]

− 7.76207

[5]

Down

[6]

Chemokine-binding protein 2

[102] array · 7 items

[0]

CCL22

[1]

− 0.68986

[2]

8.3E − 09

[3]

8.3E − 09

[4]

− 7.66358

[5]

Down

[6]

C–C motif chemokine ligand 22

[103] array · 7 items

[0]

HLA-DRA

[1]

− 1.87223

[2]

9.28E − 09

[3]

9.28E − 09

[4]

− 7.62328

[5]

Down

[6]

Major histocompatibility complex, class II, DR alpha

[104] array · 7 items

[0]

FCER1A

[1]

− 2.15768

[2]

9.79E − 09

[3]

9.79E − 09

[4]

− 7.60411

[5]

Down

[6]

Fc fragment of IgE receptor Ia

[105] array · 7 items

[0]

LILRB5

[1]

− 0.76595

[2]

1.11E − 08

[3]

1.11E − 08

[4]

− 7.55809

[5]

Down

[6]

Leukocyte immunoglobulin like receptor B5

[106] array · 7 items

[0]

CCL15

[1]

− 0.7105

[2]

1.48E − 08

[3]

1.48E − 08

[4]

− 7.4567

[5]

Down

[6]

C–C motif chemokine ligand 15

[107] array · 7 items

[0]

IL12B

[1]

− 0.99886

[2]

1.5E − 08

[3]

1.5E − 08

[4]

− 7.45174

[5]

Down

[6]

Interleukin 12B

[108] array · 7 items

[0]

TFRC

[1]

− 1.07782

[2]

1.61E − 08

[3]

1.61E − 08

[4]

− 7.42698

[5]

Down

[6]

Transferrin receptor

[109] array · 7 items

[0]

EBI3

[1]

− 0.72195

[2]

1.86E − 08

[3]

1.86E − 08

[4]

− 7.37653

[5]

Down

[6]

Epstein-Barr virus induced 3

[110] array · 7 items

[0]

IL4

[1]

− 0.69941

[2]

2.72E − 08

[3]

2.72E − 08

[4]

− 7.24189

[5]

Down

[6]

Interleukin 4

[111] array · 7 items

[0]

ICAM2

[1]

− 0.74745

[2]

2.86E − 08

[3]

2.86E − 08

[4]

− 7.22422

[5]

Down

[6]

Intercellular adhesion molecule 2

[112] array · 7 items

[0]

KLRAP1

[1]

− 1.0865

[2]

3.09E − 08

[3]

3.09E − 08

[4]

− 7.19683

[5]

Down

[6]

Killer cell lectin-like receptor subfamily A pseudogene 1

[113] array · 7 items

[0]

CD40

[1]

− 0.79436

[2]

3.29E − 08

[3]

3.29E − 08

[4]

− 7.17439

[5]

Down

[6]

CD40 molecule

[114] array · 7 items

[0]

IL22RA2

[1]

− 0.6365

[2]

4.34E − 08

[3]

4.34E − 08

[4]

− 7.07766

[5]

Down

[6]

Interleukin 22 receptor subunit alpha 2

[115] array · 7 items

[0]

IL2

[1]

− 0.64395

[2]

4.65E − 08

[3]

4.65E − 08

[4]

− 7.05298

[5]

Down

[6]

Interleukin 2

[116] array · 7 items

[0]

IL29

[1]

− 0.64395

[2]

4.65E − 08

[3]

4.65E − 08

[4]

− 7.05298

[5]

Down

[6]

Interleukin 29

[117] array · 7 items

[0]

CD3E

[1]

− 0.73018

[2]

5.24E − 08

[3]

5.24E − 08

[4]

− 7.01159

[5]

Down

[6]

CD3e molecule

[118] array · 7 items

[0]

CD55

[1]

− 0.92114

[2]

5.29E − 08

[3]

5.29E − 08

[4]

− 7.00828

[5]

Down

[6]

CD55 molecule (Cromer blood group)

[119] array · 7 items

[0]

IL19

[1]

− 0.6555

[2]

5.33E − 08

[3]

5.33E − 08

[4]

− 7.00515

[5]

Down

[6]

Interleukin 19

[120] array · 7 items

[0]

NOS2

[1]

− 0.81432

[2]

5.6E − 08

[3]

5.6E − 08

[4]

− 6.98829

[5]

Down

[6]

Nitric oxide synthase 2

[121] array · 7 items

[0]

C4BPA

[1]

− 1.83359

[2]

5.78E − 08

[3]

5.78E − 08

[4]

− 6.97697

[5]

Down

[6]

Complement component 4 binding protein alpha

[122] array · 7 items

[0]

CCL26

[1]

− 0.57677

[2]

6.5E − 08

[3]

6.5E − 08

[4]

− 6.93596

[5]

Down

[6]

C–C motif chemokine ligand 26

[123] array · 7 items

[0]

CDH5

[1]

− 0.60586

[2]

7.09E − 08

[3]

7.09E − 08

[4]

− 6.90577

[5]

Down

[6]

Cadherin 5

[124] array · 7 items

[0]

IL9

[1]

− 0.60586

[2]

7.09E − 08

[3]

7.09E − 08

[4]

− 6.90577

[5]

Down

[6]

Interleukin 9

[125] array · 7 items

[0]

FCGRT

[1]

− 0.75709

[2]

8.18E − 08

[3]

8.18E − 08

[4]

− 6.85603

[5]

Down

[6]

Fc fragment of IgG receptor and transporter

[126] array · 7 items

[0]

C8B

[1]

− 0.6555

[2]

1.1E − 07

[3]

1.1E − 07

[4]

− 6.75159

[5]

Down

[6]

Complement C8 beta chain

[127] array · 7 items

[0]

IL5

[1]

− 0.64086

[2]

1.16E − 07

[3]

1.16E − 07

[4]

− 6.7344

[5]

Down

[6]

Interleukin 5

[128] array · 7 items

[0]

PIGR

[1]

− 0.66695

[2]

1.33E − 07

[3]

1.33E − 07

[4]

− 6.68821

[5]

Down

[6]

Polymeric immunoglobulin receptor

[129] array · 7 items

[0]

XCL1

[1]

− 1.06423

[2]

1.98E − 07

[3]

1.98E − 07

[4]

− 6.54928

[5]

Down

[6]

X-C motif chemokine ligand 1

[130] array · 7 items

[0]

AIRE

[1]

− 0.78032

[2]

2.01E − 07

[3]

2.01E − 07

[4]

− 6.5441

[5]

Down

[6]

Autoimmune regulator

[131] array · 7 items

[0]

IL3

[1]

− 0.60723

[2]

2.08E − 07

[3]

2.08E − 07

[4]

− 6.53283

[5]

Down

[6]

Interleukin 3

[132] array · 7 items

[0]

CCL16

[1]

− 0.6195

[2]

2.31E − 07

[3]

2.31E − 07

[4]

− 6.4973

[5]

Down

[6]

C–C motif chemokine ligand 16

[133] array · 7 items

[0]

CCL7

[1]

− 0.6195

[2]

2.31E − 07

[3]

2.31E − 07

[4]

− 6.4973

[5]

Down

[6]

C–C motif chemokine ligand 7

[134] array · 7 items

[0]

CSF2

[1]

− 0.6195

[2]

2.31E − 07

[3]

2.31E − 07

[4]

− 6.4973

[5]

Down

[6]

Colony stimulating factor 2

[135] array · 7 items

[0]

ITLN2

[1]

− 0.6195

[2]

2.31E − 07

[3]

2.31E − 07

[4]

− 6.4973

[5]

Down

[6]

Intelectin 2

[136] array · 7 items

[0]

THY1

[1]

− 0.6195

[2]

2.31E − 07

[3]

2.31E − 07

[4]

− 6.4973

[5]

Down

[6]

Thy-1 cell surface antigen

[137] array · 7 items

[0]

IL21

[1]

− 0.70245

[2]

3.28E − 07

[3]

3.28E − 07

[4]

− 6.37574

[5]

Down

[6]

Interleukin 21

[138] array · 7 items

[0]

BCL2

[1]

− 0.7385

[2]

4.11E − 07

[3]

4.11E − 07

[4]

− 6.29854

[5]

Down

[6]

BCL2 apoptosis regulator

[139] array · 7 items

[0]

EDNRB

[1]

− 0.60541

[2]

4.11E − 07

[3]

4.11E − 07

[4]

− 6.29833

[5]

Down

[6]

Endothelin receptor type B

[140] array · 7 items

[0]

CCR6

[1]

− 0.88205

[2]

4.78E − 07

[3]

4.78E − 07

[4]

− 6.24666

[5]

Down

[6]

C–C motif chemokine receptor 6

[141] array · 7 items

[0]

TIRAP

[1]

− 0.70182

[2]

5.91E − 07

[3]

5.91E − 07

[4]

− 6.17398

[5]

Down

[6]

TIR domain containing adaptor protein

[142] array · 7 items

[0]

STAT6

[1]

− 0.52186

[2]

6.37E − 07

[3]

6.37E − 07

[4]

− 6.14848

[5]

Down

[6]

Signal transducer and activator of transcription 6

[143] array · 7 items

[0]

PSMB10

[1]

− 0.43945

[2]

6.43E − 07

[3]

6.43E − 07

[4]

− 6.14519

[5]

Down

[6]

Proteasome 20S subunit beta 10

[144] array · 7 items

[0]

SKI

[1]

− 0.52182

[2]

7.16E − 07

[3]

7.16E − 07

[4]

− 6.10886

[5]

Down

[6]

SKI proto-oncogene

[145] array · 7 items

[0]

RAG2

[1]

− 0.56723

[2]

8.47E − 07

[3]

8.47E − 07

[4]

− 6.05149

[5]

Down

[6]

Recombination activating 2

[146] array · 7 items

[0]

CD209

[1]

− 0.7285

[2]

8.56E − 07

[3]

8.56E − 07

[4]

− 6.04758

[5]

Down

[6]

CD209 molecule

[147] array · 7 items

[0]

VTN

[1]

− 0.68305

[2]

9.43E − 07

[3]

9.43E − 07

[4]

− 6.01488

[5]

Down

[6]

Vitronectin

[148] array · 7 items

[0]

IFNB1

[1]

− 0.57768

[2]

9.97E − 07

[3]

9.97E − 07

[4]

− 5.99573

[5]

Down

[6]

Interferon beta 1

[149] array · 7 items

[0]

EOMES

[1]

− 0.77505

[2]

1.47E − 06

[3]

1.47E − 06

[4]

− 5.8643

[5]

Down

[6]

Eomesodermin

[150] array · 7 items

[0]

CD74

[1]

− 0.69905

[2]

1.52E − 06

[3]

1.52E − 06

[4]

− 5.85145

[5]

Down

[6]

CD74 molecule

[151] array · 7 items

[0]

CCR10

[1]

− 0.60368

[2]

1.7E − 06

[3]

1.7E − 06

[4]

− 5.81503

[5]

Down

[6]

C–C motif chemokine receptor 10

[152] array · 7 items

[0]

LGALS3

[1]

− 1.12309

[2]

1.85E − 06

[3]

1.85E − 06

[4]

− 5.78563

[5]

Down

[6]

Galectin 3

[153] array · 7 items

[0]

PDGFB

[1]

− 0.64241

[2]

1.86E − 06

[3]

1.86E − 06

[4]

− 5.78395

[5]

Down

[6]

Platelet derived growth factor subunit B

[154] array · 7 items

[0]

ICAM4

[1]

− 0.96814

[2]

1.96E − 06

[3]

1.96E − 06

[4]

− 5.76557

[5]

Down

[6]

Intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)

[155] array · 7 items

[0]

ICOSLG

[1]

− 0.74791

[2]

2.07E − 06

[3]

2.07E − 06

[4]

− 5.74698

[5]

Down

[6]

Inducible T cell costimulator ligand

[156] array · 7 items

[0]

[1]

− 0.52132

[2]

2.66E − 06

[3]

2.66E − 06

[4]

− 5.66169

[5]

Down

[6]

Complement C9

[157] array · 7 items

[0]

IL16

[1]

− 0.45973

[2]

2.88E − 06

[3]

2.88E − 06

[4]

− 5.63467

[5]

Down

[6]

Interleukin 16

[158] array · 7 items

[0]

RELA

[1]

− 0.47205

[2]

3.09E − 06

[3]

3.09E − 06

[4]

− 5.61097

[5]

Down

[6]

RELA proto-oncogene, NF-kB subunit

[159] array · 7 items

[0]

DEFB1

[1]

− 0.8105

[2]

3.38E − 06

[3]

3.38E − 06

[4]

− 5.58051

[5]

Down

[6]

Defensin beta 1

[160] array · 7 items

[0]

IL13RA1

[1]

− 0.90159

[2]

3.41E − 06

[3]

3.41E − 06

[4]

− 5.57755

[5]

Down

[6]

Interleukin 13 receptor subunit alpha 1

[161] array · 7 items

[0]

HLA-DOB

[1]

− 1.24595

[2]

3.65E − 06

[3]

3.65E − 06

[4]

− 5.55493

[5]

Down

[6]

Major histocompatibility complex, class II, DO beta

[162] array · 7 items

[0]

KIR3DL3

[1]

− 0.56905

[2]

3.78E − 06

[3]

3.78E − 06

[4]

− 5.54244

[5]

Down

[6]

Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3

[163] array · 7 items

[0]

HLA-C

[1]

− 0.93941

[2]

3.97E − 06

[3]

3.97E − 06

[4]

− 5.52568

[5]

Down

[6]

Major histocompatibility complex, class I, C

[164] array · 7 items

[0]

KLRB1

[1]

− 1.79632

[2]

5.31E − 06

[3]

5.31E − 06

[4]

− 5.42732

[5]

Down

[6]

Killer cell lectin like receptor B1

[165] array · 7 items

[0]

HLA-DMB

[1]

− 0.85005

[2]

5.86E − 06

[3]

5.86E − 06

[4]

− 5.39367

[5]

Down

[6]

Major histocompatibility complex, class II, DM beta

[166] array · 7 items

[0]

KLRF2

[1]

− 0.53859

[2]

6E − 06

[3]

6E − 06

[4]

− 5.3857

[5]

Down

[6]

Killer cell lectin like receptor F2

[167] array · 7 items

[0]

ICAM3

[1]

− 0.66718

[2]

6.38E − 06

[3]

6.38E − 06

[4]

− 5.36481

[5]

Down

[6]

Intercellular adhesion molecule 3

[168] array · 7 items

[0]

IL28A

[1]

− 0.55718

[2]

7.03E − 06

[3]

7.03E − 06

[4]

− 5.33194

[5]

Down

[6]

Interleukin 28A

[169] array · 7 items

[0]

SIGIRR

[1]

− 0.41545

[2]

7.52E − 06

[3]

7.52E − 06

[4]

− 5.30925

[5]

Down

[6]

Single Ig and TIR domain containing

[170] array · 7 items

[0]

MASP2

[1]

− 0.68927

[2]

7.93E − 06

[3]

7.93E − 06

[4]

− 5.29109

[5]

Down

[6]

Mannan binding lectin serine peptidase 2

[171] array · 7 items

[0]

CSF2RB

[1]

− 1.12332

[2]

8.36E − 06

[3]

8.36E − 06

[4]

− 5.27318

[5]

Down

[6]

Colony stimulating factor 2 receptor beta common subunit

[172] array · 7 items

[0]

CD46

[1]

− 0.59905

[2]

9.11E − 06

[3]

9.11E − 06

[4]

− 5.24408

[5]

Down

[6]

CD46 molecule

[173] array · 7 items

[0]

S1PR1

[1]

− 0.60436

[2]

9.23E − 06

[3]

9.23E − 06

[4]

− 5.23966

[5]

Down

[6]

Sphingosine − 1-phosphate receptor 1

[174] array · 7 items

[0]

TLR9

[1]

− 0.56841

[2]

1.05E − 05

[3]

1.05E − 05

[4]

− 5.19438

[5]

Down

[6]

Toll like receptor 9

[175] array · 7 items

[0]

HLA-DPB1

[1]

− 0.70064

[2]

1.07E − 05

[3]

1.07E − 05

[4]

− 5.19046

[5]

Down

[6]

Major histocompatibility complex, class II, DP beta 1

[176] array · 7 items

[0]

CCL13

[1]

− 0.57018

[2]

1.16E − 05

[3]

1.16E − 05

[4]

− 5.16161

[5]

Down

[6]

C–C motif chemokine ligand 13

[177] array · 7 items

[0]

PLA2G2E

[1]

− 0.67155

[2]

1.19E − 05

[3]

1.19E − 05

[4]

-5.15362

[5]

Down

[6]

Phospholipase A2 group IIE

[178] array · 7 items

[0]

IL20

[1]

− 0.67032

[2]

1.29E − 05

[3]

1.29E − 05

[4]

-5.12687

[5]

Down

[6]

Interleukin 20

[179] array · 7 items

[0]

PTAFR

[1]

− 0.91373

[2]

1.37E − 05

[3]

1.37E − 05

[4]

-5.10671

[5]

Down

[6]

Platelet activating factor receptor

[180] array · 7 items

[0]

TGFBI

[1]

− 0.59209

[2]

1.44E − 05

[3]

1.44E − 05

[4]

-5.08943

[5]

Down

[6]

Transforming growth factor beta induced

[181] array · 7 items

[0]

IL26

[1]

− 0.50514

[2]

1.52E − 05

[3]

1.52E − 05

[4]

-5.07029

[5]

Down

[6]

Interleukin 26

[182] array · 7 items

[0]

IFNAR1

[1]

− 0.78755

[2]

2.03E − 05

[3]

2.03E − 05

[4]

− 4.97214

[5]

Down

[6]

Interferon alpha and beta receptor subunit 1

[183] array · 7 items

[0]

LTA

[1]

− 0.56282

[2]

2.17E − 05

[3]

2.17E − 05

[4]

− 4.94915

[5]

Down

[6]

Lymphotoxin alpha

[184] array · 7 items

[0]

FCGR2B

[1]

− 0.85355

[2]

2.4E − 05

[3]

2.4E − 05

[4]

− 4.91443

[5]

Down

[6]

Fc fragment of IgG receptor IIb

[185] array · 7 items

[0]

EGR1

[1]

− 0.63082

[2]

2.41E − 05

[3]

2.41E − 05

[4]

− 4.9133

[5]

Down

[6]

Early growth response 1

[186] array · 7 items

[0]

CD86

[1]

− 0.76691

[2]

2.54E − 05

[3]

2.54E − 05

[4]

− 4.89525

[5]

Down

[6]

CD86 molecule

[187] array · 7 items

[0]

CD82

[1]

− 0.99568

[2]

2.76E − 05

[3]

2.76E − 05

[4]

− 4.86674

[5]

Down

[6]

CD82 molecule

[188] array · 7 items

[0]

CD34

[1]

− 0.56045

[2]

2.79E − 05

[3]

2.79E − 05

[4]

− 4.86293

[5]

Down

[6]

CD34 molecule

[189] array · 7 items

[0]

TRAF3

[1]

− 0.46214

[2]

2.87E − 05

[3]

2.87E − 05

[4]

− 4.85429

[5]

Down

[6]

TNF receptor associated factor 3

[190] array · 7 items

[0]

CTLA4

[1]

− 0.53577

[2]

3E − 05

[3]

3E − 05

[4]

− 4.83886

[5]

Down

[6]

Cytotoxic T-Lymphocyte Associated Protein 4

[191] array · 7 items

[0]

HAMP

[1]

− 0.61205

[2]

3E − 05

[3]

3E − 05

[4]

− 4.83856

[5]

Down

[6]

Hepcidin antimicrobial peptide

[192] array · 7 items

[0]

EGR2

[1]

− 0.78873

[2]

3.15E − 05

[3]

3.15E − 05

[4]

− 4.82228

[5]

Down

[6]

Early growth response 2

[193] array · 7 items

[0]

ICAM5

[1]

− 0.53214

[2]

3.22E − 05

[3]

3.22E − 05

[4]

− 4.81493

[5]

Down

[6]

Intercellular adhesion molecule 5

[194] array · 7 items

[0]

CSF1R

[1]

− 0.70273

[2]

3.45E − 05

[3]

3.45E − 05

[4]

− 4.79056

[5]

Down

[6]

Colony stimulating factor 1 receptor

[195] array · 7 items

[0]

NT5E

[1]

− 0.85836

[2]

3.68E − 05

[3]

3.68E − 05

[4]

− 4.76884

[5]

Down

[6]

5′-nucleotidase ecto

[196] array · 7 items

[0]

IL7

[1]

− 0.74464

[2]

4.3E − 05

[3]

4.3E − 05

[4]

− 4.71548

[5]

Down

[6]

Interleukin 7

[197] array · 7 items

[0]

CTSS

[1]

− 0.62991

[2]

4.34E − 05

[3]

4.34E − 05

[4]

− 4.71277

[5]

Down

[6]

Cathepsin S

[198] array · 7 items

[0]

IL17B

[1]

− 0.55268

[2]

4.82E − 05

[3]

4.82E − 05

[4]

− 4.6769

[5]

Down

[6]

Interleukin 17B

[199] array · 7 items

[0]

CR2

[1]

− 1.00786

[2]

4.86E − 05

[3]

4.86E − 05

[4]

− 4.67369

[5]

Down

[6]

Complement C3d receptor 2

[200] array · 7 items

[0]

CD44

[1]

− 0.35164

[2]

5.25E − 05

[3]

5.25E − 05

[4]

− 4.64701

[5]

Down

[6]

CD44 molecule (Indian blood group)

[201] array · 7 items

[0]

PLA2G2A

[1]

− 0.53655

[2]

5.77E − 05

[3]

5.77E − 05

[4]

− 4.61492

[5]

Down

[6]

Phospholipase A2 group IIA

[202] array · 7 items

[0]

BTK

[1]

− 0.45495

[2]

5.87E − 05

[3]

5.87E − 05

[4]

− 4.60896

[5]

Down

[6]

Bruton tyrosine kinase

[203] array · 7 items

[0]

[1]

− 0.65964

[2]

5.95E − 05

[3]

5.95E − 05

[4]

− 4.60439

[5]

Down

[6]

Complement C6

[204] array · 7 items

[0]

IRGM

[1]

− 0.62291

[2]

6.21E − 05

[3]

6.21E − 05

[4]

− 4.58953

[5]

Down

[6]

Immunity related GTPase M

[205] array · 7 items

[0]

IL22

[1]

− 0.65314

[2]

7.15E − 05

[3]

7.15E − 05

[4]

− 4.54121

[5]

Down

[6]

Interleukin 22

[206] array · 7 items

[0]

CEBPB

[1]

− 0.88709

[2]

7.69E − 05

[3]

7.69E − 05

[4]

− 4.51625

[5]

Down

[6]

CCAAT enhancer binding protein beta

[207] array · 7 items

[0]

IL6

[1]

− 0.69105

[2]

7.91E − 05

[3]

7.91E − 05

[4]

− 4.50639

[5]

Down

[6]

Interleukin 6

[208] array · 7 items

[0]

IFNA2

[1]

− 0.77586

[2]

8.23E − 05

[3]

8.23E − 05

[4]

− 4.49296

[5]

Down

[6]

Interferon alpha 2

[209] array · 7 items

[0]

TGFBR1

[1]

− 0.40336

[2]

8.66E − 05

[3]

8.66E − 05

[4]

− 4.47511

[5]

Down

[6]

Transforming growth factor beta receptor 1

[210] array · 7 items

[0]

IL17F

[1]

− 0.54009

[2]

8.83E − 05

[3]

8.83E − 05

[4]

− 4.4686

[5]

Down

[6]

Interleukin 17F

[211] array · 7 items

[0]

IL28A/B

[1]

− 0.55282

[2]

0.000163

[3]

0.000163

[4]

− 4.25674

[5]

Down

[6]

Interleukin 28A/B

[212] array · 7 items

[0]

IL17A

[1]

− 0.53723

[2]

0.00018

[3]

0.00018

[4]

− 4.22236

[5]

Down

[6]

Interleukin 17A

[213] array · 7 items

[0]

LILRA2

[1]

− 0.68495

[2]

0.000195

[3]

0.000195

[4]

− 4.194

[5]

Down

[6]

Leukocyte immunoglobulin like receptor A2

[214] array · 7 items

[0]

LILRA3

[1]

− 2.33691

[2]

0.000203

[3]

0.000203

[4]

− 4.18055

[5]

Down

[6]

Leukocyte immunoglobulin like receptor A3

[215] array · 7 items

[0]

VCAM1

[1]

− 0.60605

[2]

0.000219

[3]

0.000219

[4]

− 4.15259

[5]

Down

[6]

Vascular cell adhesion molecule 1

[216] array · 7 items

[0]

SPP1

[1]

− 0.6555

[2]

0.000221

[3]

0.000221

[4]

− 4.1496

[5]

Down

[6]

Secreted phosphoprotein 1

[217] array · 7 items

[0]

CARD9

[1]

− 0.55227

[2]

0.000269

[3]

0.000269

[4]

− 4.0818

[5]

Down

[6]

Caspase recruitment domain family member 9

[218] array · 7 items

[0]

LCK

[1]

− 0.40364

[2]

0.000299

[3]

0.000299

[4]

− 4.04398

[5]

Down

[6]

LCK proto-oncogene, Src family tyrosine kinase

[219] array · 7 items

[0]

SELE

[1]

− 0.52332

[2]

0.000306

[3]

0.000306

[4]

− 4.03551

[5]

Down

[6]

selectin E

[220] array · 7 items

[0]

SLC2A1

[1]

− 0.44118

[2]

0.00036

[3]

0.00036

[4]

− 3.97865

[5]

Down

[6]

solute carrier family 2 member 1

[221] array · 7 items

[0]

LIF

[1]

− 0.50555

[2]

0.000368

[3]

0.000368

[4]

− 3.97037

[5]

Down

[6]

LIF interleukin 6 family cytokine

[222] array · 7 items

[0]

IDO1

[1]

− 0.95541

[2]

0.000417

[3]

0.000417

[4]

− 3.92685

[5]

Down

[6]

Indoleamine 2,3-dioxygenase 1

[223] array · 7 items

[0]

TNFRSF10C

[1]

− 0.88564

[2]

0.000471

[3]

0.000471

[4]

− 3.88294

[5]

Down

[6]

TNF receptor superfamily member 10c

[224] array · 7 items

[0]

IL23A

[1]

− 0.87541

[2]

0.000557

[3]

0.000557

[4]

− 3.82374

[5]

Down

[6]

interleukin 23 subunit alpha

[225] array · 7 items

[0]

CD80

[1]

− 0.58964

[2]

0.000567

[3]

0.000567

[4]

− 3.81702

[5]

Down

[6]

CD80 molecule

[226] array · 7 items

[0]

GPR183

[1]

− 1.088

[2]

0.00057

[3]

0.00057

[4]

− 3.81527

[5]

Down

[6]

G protein-coupled receptor 183

[227] array · 7 items

[0]

C1R

[1]

− 0.41727

[2]

0.000592

[3]

0.000592

[4]

− 3.8018

[5]

Down

[6]

Complement C1r

[228] array · 7 items

[0]

CCL11

[1]

− 0.55055

[2]

0.000611

[3]

0.000611

[4]

− 3.79064

[5]

Down

[6]

C–C motif chemokine ligand 11

[229] array · 7 items

[0]

HLA-DPA1

[1]

− 0.6385

[2]

0.000637

[3]

0.000637

[4]

− 3.77577

[5]

Down

[6]

major histocompatibility complex, class II, DP alpha 1

[230] array · 7 items

[0]

IFNG

[1]

− 0.877

[2]

0.00073

[3]

0.00073

[4]

− 3.72658

[5]

Down

[6]

Interferon gamma

[231] array · 7 items

[0]

DUSP4

[1]

− 0.70741

[2]

0.000789

[3]

0.000789

[4]

− 3.69861

[5]

Down

[6]

Dual specificity phosphatase 4

[232] array · 7 items

[0]

IL27

[1]

− 0.44905

[2]

0.000852

[3]

0.000852

[4]

− 3.67089

[5]

Down

[6]

Interleukin 27

[233] array · 7 items

[0]

CD48

[1]

− 1.15805

[2]

0.000953

[3]

0.000953

[4]

− 3.6304

[5]

Down

[6]

CD48 molecule

[234] array · 7 items

[0]

FN1

[1]

− 0.56177

[2]

0.001005

[3]

0.001005

[4]

− 3.61111

[5]

Down

[6]

fibronectin 1

[235] array · 7 items

[0]

CD244

[1]

− 0.39427

[2]

0.001018

[3]

0.001018

[4]

− 3.60646

[5]

Down

[6]

CD244 molecule

[236] array · 7 items

[0]

PPBP

[1]

− 1.35464

[2]

0.001091

[3]

0.001091

[4]

− 3.58105

[5]

Down

[6]

pro-platelet basic protein

[237] array · 7 items

[0]

IL13

[1]

− 0.599

[2]

0.001204

[3]

0.001204

[4]

− 3.54515

[5]

Down

[6]

interleukin 13

[238] array · 7 items

[0]

CCL24

[1]

− 0.45395

[2]

0.001221

[3]

0.001221

[4]

− 3.53987

[5]

Down

[6]

C–C motif chemokine ligand 24

[239] array · 7 items

[0]

GATA3

[1]

− 0.55041

[2]

0.001228

[3]

0.001228

[4]

− 3.53797

[5]

Down

[6]

GATA binding protein 3

[240] array · 7 items

[0]

BID

[1]

− 0.46636

[2]

0.001281

[3]

0.001281

[4]

− 3.52243

[5]

Down

[6]

BH3 interacting domain death agonist

[241] array · 7 items

[0]

BCL2L11

[1]

− 0.40091

[2]

0.001565

[3]

0.001565

[4]

− 3.44881

[5]

Down

[6]

BCL2 like 11

[242] array · 7 items

[0]

KIT

[1]

− 0.52868

[2]

0.001589

[3]

0.001589

[4]

− 3.44316

[5]

Down

[6]

KIT proto-oncogene, receptor tyrosine kinase

[243] array · 7 items

[0]

MME

[1]

− 1.00591

[2]

0.001596

[3]

0.001596

[4]

− 3.44151

[5]

Down

[6]

Membrane metalloendopeptidase

[244] array · 7 items

[0]

ZEB1

[1]

− 0.38082

[2]

0.001667

[3]

0.001667

[4]

− 3.42548

[5]

Down

[6]

Zinc finger E-box binding homeobox 1

[245] array · 7 items

[0]

C4A/B

[1]

− 0.62314

[2]

0.001738

[3]

0.001738

[4]

− 3.40994

[5]

Down

[6]

Complement C4A/B

[246] array · 7 items

[0]

FCAR

[1]

− 0.50423

[2]

0.00198

[3]

0.00198

[4]

− 3.36169

[5]

Down

[6]

Fc fragment of IgA receptor

[247] array · 7 items

[0]

BTLA

[1]

− 0.45623

[2]

0.002033

[3]

0.002033

[4]

− 3.35183

[5]

Down

[6]

B and T lymphocyte associated

[248] array · 7 items

[0]

TAGAP

[1]

− 0.38886

[2]

0.002261

[3]

0.002261

[4]

− 3.31206

[5]

Down

[6]

T cell activation RhoGTPase activating protein

[249] array · 7 items

[0]

CD83

[1]

− 0.39914

[2]

0.002292

[3]

0.002292

[4]

− 3.307

[5]

Down

[6]

CD83 molecule

[250] array · 7 items

[0]

SELPLG

[1]

− 0.37564

[2]

0.002362

[3]

0.002362

[4]

-3.29575

[5]

Down

[6]

Selectin P ligand

[251] array · 7 items

[0]

B3GAT1

[1]

− 0.66791

[2]

0.002423

[3]

0.002423

[4]

− 3.28614

[5]

Down

[6]

Beta-1,3-glucuronyltransferase 1

[252] array · 7 items

[0]

CCRL1

[1]

− 0.39195

[2]

0.002543

[3]

0.002543

[4]

− 3.26788

[5]

Down

[6]

C–C chemokine receptor type 11

[253] array · 7 items

[0]

TNFRSF14

[1]

− 0.29986

[2]

0.002557

[3]

0.002557

[4]

− 3.26588

[5]

Down

[6]

TNF receptor superfamily member 14

[254] array · 7 items

[0]

CSF3R

[1]

− 0.65318

[2]

0.003003

[3]

0.003003

[4]

− 3.20507

[5]

Down

[6]

Colony stimulating factor 3 receptor

[255] array · 7 items

[0]

CD9

[1]

− 0.87091

[2]

0.003004

[3]

0.003004

[4]

− 3.20497

[5]

Down

[6]

CD9 molecule

[256] array · 7 items

[0]

C1S

[1]

− 0.52059

[2]

0.003211

[3]

0.003211

[4]

− 3.17969

[5]

Down

[6]

complement C1s

[257] array · 7 items

[0]

PECAM1

[1]

− 0.30873

[2]

0.003251

[3]

0.003251

[4]

− 3.17496

[5]

Down

[6]

platelet and endothelial cell adhesion molecule 1

[258] array · 7 items

[0]

DEFB103B

[1]

− 0.4315

[2]

0.003466

[3]

0.003466

[4]

− 3.15055

[5]

Down

[6]

Defensin beta 103B

[259] array · 7 items

[0]

ITLN1

[1]

− 1.17682

[2]

0.003488

[3]

0.003488

[4]

− 3.14815

[5]

Down

[6]

Intelectin 1

[260] array · 7 items

[0]

CXCL13

[1]

− 0.46586

[2]

0.003554

[3]

0.003554

[4]

− 3.14101

[5]

Down

[6]

C-X-C motif chemokine ligand 13

[261] array · 7 items

[0]

RAG1

[1]

− 0.47836

[2]

0.003917

[3]

0.003917

[4]

− 3.10376

[5]

Down

[6]

Recombination activating 1

[262] array · 7 items

[0]

TNFRSF4

[1]

− 0.55123

[2]

0.004154

[3]

0.004154

[4]

− 3.08112

[5]

Down

[6]

TNF receptor superfamily member 4

[263] array · 7 items

[0]

C14orf166

[1]

− 0.35727

[2]

0.004255

[3]

0.004255

[4]

− 3.07189

[5]

Down

[6]

Chromosome 14 open reading frame 166

[264] array · 7 items

[0]

IL10RA

[1]

− 0.26059

[2]

0.004423

[3]

0.004423

[4]

− 3.0569

[5]

Down

[6]

Interleukin 10 receptor subunit alpha

[265] array · 7 items

[0]

POU2F2

[1]

− 0.292

[2]

0.004614

[3]

0.004614

[4]

− 3.04059

[5]

Down

[6]

POU class 2 homeobox 2

[266] array · 7 items

[0]

[1]

− 0.41223

[2]

0.004688

[3]

0.004688

[4]

− 3.03441

[5]

Down

[6]

complement C7

[267] array · 7 items

[0]

RORC

[1]

− 0.52768

[2]

0.005006

[3]

0.005006

[4]

− 3.00891

[5]

Down

[6]

RAR related orphan receptor C

[268] array · 7 items

[0]

CXCL11

[1]

− 0.83891

[2]

0.005151

[3]

0.005151

[4]

− 2.99784

[5]

Down

[6]

C-X-C motif chemokine ligand 11

[269] array · 7 items

[0]

MASP1

[1]

− 0.50677

[2]

0.005182

[3]

0.005182

[4]

− 2.99543

[5]

Down

[6]

Mannan binding lectin serine peptidase 1

[270] array · 7 items

[0]

MAP4K4

[1]

− 0.37777

[2]

0.005449

[3]

0.005449

[4]

− 2.97583

[5]

Down

[6]

Mitogen-activated protein kinase kinasekinasekinase 4

[271] array · 7 items

[0]

CX3CL1

[1]

− 0.50445

[2]

0.005597

[3]

0.005597

[4]

− 2.96535

[5]

Down

[6]

C-X3-C motif chemokine ligand 1

[272] array · 7 items

[0]

BATF3

[1]

− 0.62586

[2]

0.005862

[3]

0.005862

[4]

− 2.94725

[5]

Down

[6]

Basic leucine zipper ATF-like transcription factor 3

[273] array · 7 items

[0]

CCR8

[1]

− 0.51627

[2]

0.005946

[3]

0.005946

[4]

− 2.94164

[5]

Down

[6]

C–C motif chemokine receptor 8

[274] array · 7 items

[0]

TAL1

[1]

− 1.01455

[2]

0.006016

[3]

0.006016

[4]

− 2.93707

[5]

Down

[6]

TAL bHLH transcription factor 1, erythroid differentiation factor

[275] array · 7 items

[0]

NFIL3

[1]

− 0.723

[2]

0.007

[3]

0.007

[4]

− 2.87725

[5]

Down

[6]

Nuclear factor, interleukin 3 regulated

[276] array · 7 items

[0]

CD8A

[1]

− 0.50595

[2]

0.007337

[3]

0.007337

[4]

− 2.85858

[5]

Down

[6]

CD8a molecule

[277] array · 7 items

[0]

CLEC6A

[1]

− 0.62323

[2]

0.007445

[3]

0.007445

[4]

− 2.85274

[5]

Down

[6]

C-type lectin domain containing 6A

[278] array · 7 items

[0]

TCF4

[1]

− 0.37827

[2]

0.007904

[3]

0.007904

[4]

− 2.8289

[5]

Down

[6]

Transcription factor 4

[279] array · 7 items

[0]

FCGR2A

[1]

− 0.664

[2]

0.009089

[3]

0.009089

[4]

− 2.77283

[5]

Down

[6]

Fc fragment of IgG receptor IIa

[280] array · 7 items

[0]

HLA-B

[1]

− 0.31677

[2]

0.00918

[3]

0.00918

[4]

− 2.76877

[5]

Down

[6]

major histocompatibility complex, class I, B

[281] array · 7 items

[0]

IRF8

[1]

− 0.39477

[2]

0.009346

[3]

0.009346

[4]

− 2.76157

[5]

Down

[6]

Interferon regulatory factor 8

[282] array · 7 items

[0]

MAPK11

[1]

− 0.60427

[2]

0.010152

[3]

0.010152

[4]

− 2.72804

[5]

Down

[6]

Mitogen-activated protein kinase 11

[283] array · 7 items

[0]

ILF3

[1]

− 0.17055

[2]

0.010366

[3]

0.010366

[4]

− 2.71958

[5]

Down

[6]

Interleukin enhancer binding factor 3

[284] array · 7 items

[0]

XCR1

[1]

− 0.34541

[2]

0.01065

[3]

0.01065

[4]

− 2.70856

[5]

Down

[6]

X–C motif chemokine receptor 1

[285] array · 7 items

[0]

ITGAE

[1]

− 0.33509

[2]

0.011424

[3]

0.011424

[4]

− 2.67988

[5]

Down

[6]

Integrin subunit alpha E

[286] array · 7 items

[0]

IL4R

[1]

− 0.69064

[2]

0.012538

[3]

0.012538

[4]

− 2.64162

[5]

Down

[6]

Interleukin 4 receptor

[287] array · 7 items

[0]

CTSC

[1]

− 0.16718

[2]

0.012619

[3]

0.012619

[4]

− 2.63897

[5]

Down

[6]

Cathepsin C

[288] array · 7 items

[0]

ETS1

[1]

− 0.39405

[2]

0.013255

[3]

0.013255

[4]

− 2.61865

[5]

Down

[6]

ETS proto-oncogene 1, transcription factor

[289] array · 7 items

[0]

CFI

[1]

− 0.30082

[2]

0.013335

[3]

0.013335

[4]

− 2.61614

[5]

Down

[6]

Complement factor I

[290] array · 7 items

[0]

STAT5A

[1]

− 0.27168

[2]

0.014802

[3]

0.014802

[4]

− 2.57273

[5]

Down

[6]

Signal transducer and activator of transcription 5A

[291] array · 7 items

[0]

C8A

[1]

− 0.37964

[2]

0.016204

[3]

0.016204

[4]

− 2.53478

[5]

Down

[6]

Complement C8 alpha chain

[292] array · 7 items

[0]

DEFB4A

[1]

− 0.36691

[2]

0.017835

[3]

0.017835

[4]

− 2.49428

[5]

Down

[6]

Defensin beta 4A

[293] array · 7 items

[0]

RELB

[1]

− 0.45095

[2]

0.019351

[3]

0.019351

[4]

− 2.45958

[5]

Down

[6]

RELB proto-oncogene, NF-kB subunit

[294] array · 7 items

[0]

ATG7

[1]

− 0.32859

[2]

0.01984

[3]

0.01984

[4]

− 2.4489

[5]

Down

[6]

Autophagy related 7

[295] array · 7 items

[0]

DPP4

[1]

− 0.38823

[2]

0.01999

[3]

0.01999

[4]

− 2.44568

[5]

Down

[6]

Dipeptidyl peptidase 4

[296] array · 7 items

[0]

GPI

[1]

− 0.21382

[2]

0.020424

[3]

0.020424

[4]

− 2.43646

[5]

Down

[6]

Glucose-6-phosphate isomerase

[297] array · 7 items

[0]

CD59

[1]

− 0.24032

[2]

0.020561

[3]

0.020561

[4]

− 2.43359

[5]

Down

[6]

CD59 molecule (CD59 blood group)

[298] array · 7 items

[0]

CASP3

[1]

− 0.40573

[2]

0.025629

[3]

0.025629

[4]

− 2.33807

[5]

Down

[6]

Caspase 3

[299] array · 7 items

[0]

TIGIT

[1]

− 0.3615

[2]

0.025963

[3]

0.025963

[4]

− 2.33239

[5]

Down

[6]

T cell immunoreceptor with Ig and ITIM domains

[300] array · 7 items

[0]

CFD

[1]

− 0.36627

[2]

0.026073

[3]

0.026073

[4]

− 2.33053

[5]

Down

[6]

Complement factor D

[301] array · 7 items

[0]

CCL18

[1]

− 0.42077

[2]

0.026944

[3]

0.026944

[4]

− 2.3161

[5]

Down

[6]

C–C motif chemokine ligand 18

[302] array · 7 items

[0]

PLAU

[1]

− 0.34086

[2]

0.028132

[3]

0.028132

[4]

− 2.29706

[5]

Down

[6]

Plasminogen activator, urokinase

[303] array · 7 items

[0]

PTPN22

[1]

− 0.20086

[2]

0.028829

[3]

0.028829

[4]

− 2.28623

[5]

Down

[6]

Protein tyrosine phosphatase non-receptor type 22

[304] array · 7 items

[0]

TOLLIP

[1]

− 0.27377

[2]

0.028911

[3]

0.028911

[4]

− 2.28497

[5]

Down

[6]

Toll interacting protein

[305] array · 7 items

[0]

CXCR2

[1]

− 0.49195

[2]

0.029438

[3]

0.029438

[4]

− 2.27696

[5]

Down

[6]

C-X-C motif chemokine receptor 2

[306] array · 7 items

[0]

CCL20

[1]

− 0.34555

[2]

0.029871

[3]

0.029871

[4]

− 2.27048

[5]

Down

[6]

C–C motif chemokine ligand 20

[307] array · 7 items

[0]

IL12A

[1]

− 0.40759

[2]

0.03046

[3]

0.03046

[4]

− 2.26179

[5]

Down

[6]

Interleukin 12A

[308] array · 7 items

[0]

IL10

[1]

− 0.33555

[2]

0.03205

[3]

0.03205

[4]

− 2.23904

[5]

Down

[6]

Interleukin 10

[309] array · 7 items

[0]

LILRA1

[1]

− 0.26991

[2]

0.033542

[3]

0.033542

[4]

− 2.21862

[5]

Down

[6]

leukocyte immunoglobulin like receptor A1

[310] array · 7 items

[0]

PTPN6

[1]

− 0.16109

[2]

0.034722

[3]

0.034722

[4]

− 2.20304

[5]

Down

[6]

protein tyrosine phosphatase non-receptor type 6

[311] array · 7 items

[0]

CCL19

[1]

− 0.37718

[2]

0.035605

[3]

0.035605

[4]

− 2.19168

[5]

Down

[6]

C–C motif chemokine ligand 19

[312] array · 7 items

[0]

IKBKAP

[1]

− 0.15505

[2]

0.035624

[3]

0.035624

[4]

− 2.19144

[5]

Down

[6]

IκB kinase complex-associated protein

[313] array · 7 items

[0]

TNFRSF9

[1]

− 0.50786

[2]

0.036235

[3]

0.036235

[4]

− 2.18372

[5]

Down

[6]

TNF receptor superfamily member 9

[314] array · 7 items

[0]

TCF7

[1]

− 0.60091

[2]

0.036564

[3]

0.036564

[4]

− 2.17963

[5]

Down

[6]

Transcription factor 7

[315] array · 7 items

[0]

HLA-DMA

[1]

− 0.30777

[2]

0.036925

[3]

0.036925

[4]

− 2.17516

[5]

Down

[6]

Major histocompatibility complex, class II, DM alpha

[316] array · 7 items

[0]

CXCL12

[1]

− 0.69291

[2]

0.037168

[3]

0.037168

[4]

− 2.17218

[5]

Down

[6]

C-X-C motif chemokine ligand 12

[317] array · 7 items

[0]

MBL2

[1]

− 0.37009

[2]

0.037623

[3]

0.037623

[4]

− 2.16664

[5]

Down

[6]

Mannose binding lectin 2

[318] array · 7 items

[0]

IKZF2

[1]

− 0.46655

[2]

0.039489

[3]

0.039489

[4]

− 2.14452

[5]

Down

[6]

IKAROS family zinc finger 2

[319] array · 7 items

[0]

BCAP31

[1]

− 0.10632

[2]

0.04075

[3]

0.04075

[4]

− 2.13009

[5]

Down

[6]

B cell receptor associated protein 31

[320] array · 7 items

[0]

HLA-DRB1

[1]

− 1.39495

[2]

0.041403

[3]

0.041403

[4]

− 2.12278

[5]

Down

[6]

Major histocompatibility complex, class II, DR beta 1

[321] array · 7 items

[0]

IRAK4

[1]

− 0.23727

[2]

0.041428

[3]

0.041428

[4]

− 2.12251

[5]

Down

[6]

Interleukin 1 receptor associated kinase 4

[322] array · 7 items

[0]

CXCR1

[1]

− 0.49741

[2]

0.041833

[3]

0.041833

[4]

− 2.11802

[5]

Down

[6]

C-X-C motif chemokine receptor 1

[323] array · 7 items

[0]

PTK2

[1]

− 0.33609

[2]

0.043242

[3]

0.043242

[4]

− 2.10272

[5]

Down

[6]

Protein tyrosine kinase 2

[324] array · 7 items

[0]

CD45R0

[1]

− 0.46514

[2]

0.043373

[3]

0.043373

[4]

− 2.10132

[5]

Down

[6]

A member of leucocyte common antigen family

row_count

325

column_count

numeric_cells

1605

header_rows

locator

section[12]/table-wrap[1]#Tab1

[11] object · 16 fields

asset:table:pmid:33251083:10

role

table

format

jats-table

media_type

application/vnd.jats.table+json

uri

null

sha256

sha256:b7239eaa56eb9da9deefd70f1c000d77539072c6a251173f715314d5547a318e

bytes

10374

access

open

state

verified

reader

read_table

reader_status

available

identifier

section[13]/table-wrap[1]#Tab2

version

null

note

The enriched pathway terms of the up regulated differentially expressed genes

structure object · 5 fields

pmcid

PMC7679428

section_index

section_title

Pathway enrichment analysis for DEGs

row_count

column_count

table object · 8 fields

label

Table 2

caption

The enriched pathway terms of the up regulated differentially expressed genes

rows array · 73 items

[0] array · 1 item

[0]

KEGG

[1] array · 8 items

[0]

Pathway ID

[1]

Pathway Name

[2]

P-value

[3]

FDR B&H

[4]

FDR B&Y

[5]

Bonferroni

[6]

Gene Count

[7]

Gene

[2] array · 8 items

[0]

213306

[1]

Measles

[2]

3.21E − 17

[3]

4.46E − 15

[4]

2.46E − 14

[5]

4.46E − 15

[6]

[7]

CCND3, JAK1, JAK2, IFIH1, TRAF6, IKBKE, TLR2, IRF7, FYN, IL2RG, STAT1, TP53, STAT3, MX1, STAT5B, IFNAR2

[3] array · 8 items

[0]

377873

[1]

Herpes simplex infection

[2]

1.19E − 13

[3]

8.24E − 12

[4]

4.54E − 11

[5]

1.65E − 11

[6]

[7]

JAK1, JAK2, IFIH1, TRAF2, TRAF6, HLA-A, IKBKE, TLR2, C1QBP, CCL5, IRF7, IKBKB, STAT1, TP53, IFNAR2

[4] array · 8 items

[0]

83079

[1]

Natural killer cell mediated cytotoxicity

[2]

5.40E − 13

[3]

2.50E − 11

[4]

1.38E − 10

[5]

7.51E − 11

[6]

[7]

KLRK1, CD247, HLA-A, GZMB, HRAS, LCP2, ITGAL, FYN, ITGB2, KLRC1, ZAP70, KLRD1, IFNAR2

[5] array · 8 items

[0]

193147

[1]

Osteoclast differentiation

[2]

1.85E − 10

[3]

3.32E − 09

[4]

1.83E − 08

[5]

2.57E − 08

[6]

[7]

JAK1, TRAF2, TRAF6, LILRB2, LILRA6, SOCS1, IKBKB, LCP2, FYN, STAT1, IFNAR2

[6] array · 8 items

[0]

83077

[1]

Jak-STAT signaling pathway

[2]

1.31E − 09

[3]

1.83E − 08

[4]

1.01E − 07

[5]

1.83E − 07

[6]

[7]

CCND3, JAK1, JAK2, HRAS, SOCS1, IL2RG, STAT1, STAT3, STAT4, STAT5B, IFNAR2

[7] array · 8 items

[0]

217173

[1]

Influenza A

[2]

3.94E − 09

[3]

4.56E − 08

[4]

2.51E − 07

[5]

5.47E − 07

[6]

[7]

JAK1, JAK2, IFIH1, IKBKE, CCL5, IRF7, IKBKB, STAT1, NLRP3, MX1, IFNAR2

[8] array · 8 items

[0]

373901

[1]

HTLV-I infection

[2]

2.27E − 08

[3]

2.11E − 07

[4]

1.16E − 06

[5]

3.16E − 06

[6]

[7]

CCND3, JAK1, HLA-A, HRAS, XBP1, CTNNB1, IKBKB, ITGAL, ITGB2, IL2RG, TP53, STAT5B

[9] array · 8 items

[0]

658418

[1]

Viral carcinogenesis

[2]

2.16E − 07

[3]

1.67E − 06

[4]

9.20E − 06

[5]

3.00E − 05

[6]

[7]

CCND3, JAK1, TRAF2, HLA-A, HRAS, IRF7, CCR5, TP53, STAT3, STAT5B

[10] array · 8 items

[0]

83080

[1]

T cell receptor signaling pathway

[2]

2.05E − 06

[3]

1.36E − 05

[4]

7.47E − 05

[5]

2.85E − 04

[6]

[7]

PDCD1, CD247, HRAS, IKBKB, LCP2, FYN, ZAP70

[11] array · 8 items

[0]

125138

[1]

Viral myocarditis

[2]

2.21E − 05

[3]

1.18E − 04

[4]

6.51E − 04

[5]

3.07E − 03

[6]

[7]

ABL1, HLA-A, ITGAL, FYN, ITGB2

[12] array · 8 items

[0]

213780

[1]

Tuberculosis

[2]

7.57E − 05

[3]

3.63E − 04

[4]

2.00E − 03

[5]

1.05E − 02

[6]

[7]

JAK1, JAK2, TRAF6, TLR2, CLEC7A, ITGB2, STAT1

[13] array · 8 items

[0]

83051

[1]

Cytokine-cytokine receptor interaction

[2]

1.59E − 04

[3]

6.69E − 04

[4]

3.69E − 03

[5]

2.21E − 02

[6]

[7]

CCR1, CCL5, CCR5, IL18RAP, IL2RG, IL18R1, CX3CR1, IFNAR2

[14] array · 8 items

[0]

152665

[1]

Malaria

[2]

1.79E − 04

[3]

7.32E − 04

[4]

4.04E − 03

[5]

2.49E − 02

[6]

[7]

KLRK1, TLR2, ITGAL, ITGB2

[15] array · 1 item

[0]

Pathway interaction database

[16] array · 8 items

[0]

137922

[1]

IL12-mediated signaling events

[2]

1.37E − 17

[3]

1.56E − 15

[4]

8.29E − 15

[5]

1.56E − 15

[6]

[7]

JAK2, CD247, HLA-A, TBX21, GZMB, SOCS1, CCR5, IL18RAP, IL2RG, IL18R1, STAT1, STAT3, STAT4

[17] array · 8 items

[0]

137976

[1]

IL2-mediated signaling events

[2]

5.15E − 10

[3]

2.94E − 08

[4]

1.56E − 07

[5]

5.88E − 08

[6]

[7]

JAK1, IKZF3, SOCS1, FYN, IL2RG, STAT1, STAT3, STAT5B

[18] array · 8 items

[0]

138055

[1]

TCR signaling in naive CD8 + T cells

[2]

9.79E − 09

[3]

2.35E − 07

[4]

1.25E − 06

[5]

1.12E − 06

[6]

[7]

TRAF6, CD247, HLA-A, IKBKB, LCP2, FYN, ZAP70

[19] array · 8 items

[0]

138071

[1]

PDGFR-beta signaling pathway

[2]

6.28E − 07

[3]

7.16E − 06

[4]

3.81E − 05

[5]

7.16E − 05

[6]

[7]

ABL1, HRAS, FYN, STAT1, STAT3, STAT5B

[20] array · 8 items

[0]

137988

[1]

IL2 signaling events mediated by STAT5

[2]

2.52E − 05

[3]

2.21E − 04

[4]

1.17E − 03

[5]

2.87E − 03

[6]

[7]

CCND3, JAK1, IL2RG, STAT5B

[21] array · 8 items

[0]

138019

[1]

p75(NTR)-mediated signaling

[2]

5.25E − 03

[3]

2.32E − 02

[4]

1.23E − 01

[5]

5.99E − 01

[6]

[7]

TRAF6, IKBKB, TP53

[22] array · 8 items

[0]

138021

[1]

Paxillin-dependent events mediated by a4b1

[2]

5.29E − 03

[3]

2.32E − 02

[4]

1.23E − 01

[5]

6.03E − 01

[6]

[7]

ITGAL, ITGB2

[23] array · 8 items

[0]

137940

[1]

Signaling events mediated by VEGFR1 and VEGFR2

[2]

5.75E − 03

[3]

2.43E − 02

[4]

1.29E − 01

[5]

6.55E − 01

[6]

[7]

HRAS, CTNNB1, FYN

[24] array · 8 items

[0]

137983

[1]

ALK2 signaling events

[2]

6.18E − 02

[3]

1.22E − 01

[4]

6.47E − 01

[5]

1.00E + 00

[6]

[7]

SMAD5

[25] array · 8 items

[0]

138046

[1]

Syndecan-1-mediated signaling events

[2]

9.40E − 02

[3]

1.70E − 01

[4]

9.04E − 01

[5]

1.00E + 00

[6]

[7]

CCL5

[26] array · 1 item

[0]

REACTOME

[27] array · 8 items

[0]

1269310

[1]

Cytokine Signaling in Immune system

[2]

3.94E − 16

[3]

2.05E − 13

[4]

1.40E − 12

[5]

2.05E − 13

[6]

[7]

JAK1, JAK2, TRAF2, TRAF6, HLA-A, BST2, HRAS, PSMB9, GBP1, SOCS1, CCR1, IRF5, CCL5, IRF7, CCR5, IKBKB, FYN, IFI35, IL18RAP, ITGB2, IL2RG, IL18R1, STAT1, TP53, STAT3, MX1, STAT5B, IFNAR2

[28] array · 8 items

[0]

1269203

[1]

Innate Immune System

[2]

1.61E − 13

[3]

4.19E − 11

[4]

2.86E − 10

[5]

8.38E − 11

[6]

[7]

[29] array · 8 items

[0]

1269318

[1]

Signaling by Interleukins

[2]

9.69E − 11

[3]

1.06E − 08

[4]

7.24E − 08

[5]

5.04E − 08

[6]

[7]

JAK1, JAK2, TRAF6, HRAS, PSMB9, SOCS1, CCR1, CCL5, CCR5, IKBKB, FYN, IL18RAP, ITGB2, IL2RG, IL18R1, STAT1, TP53, STAT3, STAT5B

[30] array · 8 items

[0]

1269171

[1]

Adaptive Immune System

[2]

1.02E − 10

[3]

1.06E − 08

[4]

7.24E − 08

[5]

5.30E − 08

[6]

[7]

KLRK1, PDCD1, TRAF6, CD247, ZBTB16, HLA-A, LILRB2, TLR2, LAG3, HRAS, LILRA6, PSMB9, SOCS1, SLAMF7, IKBKB, LCP2, ITGAL, FYN, ITGB2, KLRC1, ZAP70, KLRD1, TP53

[31] array · 8 items

[0]

1269340

[1]

Hemostasis

[2]

5.49E − 07

[3]

2.20E − 05

[4]

1.50E − 04

[5]

2.86E − 04

[6]

[7]

JAK1, JAK2, ABL1, CD99, HRAS, C1QBP, SERPING1, IRF7, LCP2, ITGAL, FYN, ITGB2, IL2RG, TP53, CEACAM1, GP1BB

[32] array · 8 items

[0]

1269260

[1]

TRAF3-dependent IRF activation pathway

[2]

9.84E − 05

[3]

1.55E − 03

[4]

1.06E − 02

[5]

5.12E − 02

[6]

[7]

IFIH1, IKBKE, IRF7

[33] array · 8 items

[0]

1268854

[1]

Disease

[2]

1.26E − 03

[3]

1.24E − 02

[4]

8.44E − 02

[5]

6.55E − 01

[6]

[7]

JAK2, CD247, HLA-A, TLR2, HRAS, PSMB9, CCR5, CTNNB1, IKBKB, FYN, STAT1, STAT3, STAT5B

[34] array · 8 items

[0]

1268855

[1]

Diseases of signal transduction

[2]

1.35E − 03

[3]

1.30E − 02

[4]

8.90E − 02

[5]

7.03E − 01

[6]

[7]

JAK2, HRAS, PSMB9, CTNNB1, FYN, STAT1, STAT3, STAT5B

[35] array · 8 items

[0]

1269562

[1]

Leukotriene receptors

[2]

2.86E − 02

[3]

8.96E − 02

[4]

6.12E − 01

[5]

1.00E + 00

[6]

[7]

LTB4R

[36] array · 8 items

[0]

1269248

[1]

Activation of C3 and C5

[2]

3.98E − 02

[3]

1.18E − 01

[4]

8.08E − 01

[5]

1.00E + 00

[6]

[7]

[37] array · 1 item

[0]

MSigDB C2 BIOCARTA (v6.0)

[38] array · 8 items

[0]

M8066

[1]

IL22 Soluble Receptor Signaling Pathway

[2]

2.31E − 10

[3]

3.56E − 08

[4]

2.00E − 07

[5]

3.56E − 08

[6]

[7]

JAK1, JAK2, STAT1, STAT3, STAT4, STAT5B

[39] array · 8 items

[0]

M13494

[1]

Bioactive Peptide Induced Signaling Pathway

[2]

4.38E − 09

[3]

3.38E − 07

[4]

1.90E − 06

[5]

6.75E − 07

[6]

[7]

JAK2, HRAS, FYN, STAT1, STAT3, STAT4, STAT5B

[40] array · 8 items

[0]

M1462

[1]

CTL mediated immune response against target cells

[2]

1.61E − 08

[3]

7.50E − 07

[4]

4.21E − 06

[5]

2.48E − 06

[6]

[7]

CD247, HLA-A, GZMB, ITGAL, ITGB2

[41] array · 8 items

[0]

M6231

[1]

NO2-dependent IL 12 Pathway in NK cells

[2]

2.31E − 06

[3]

3.24E − 05

[4]

1.82E − 04

[5]

3.56E − 04

[6]

[7]

JAK2, CD247, CCR5, STAT4

[42] array · 8 items

[0]

M13863

[1]

MAPKinaseSignaling Pathway

[2]

1.06E − 05

[3]

1.08E − 04

[4]

6.09E − 04

[5]

1.63E − 03

[6]

[7]

TRAF2, MAP4K1, HRAS, IKBKB, MAP4K2, STAT1

[43] array · 8 items

[0]

M6427

[1]

T Helper Cell Surface Molecules

[2]

6.45E − 05

[3]

4.73E − 04

[4]

2.66E − 03

[5]

9.93E − 03

[6]

[7]

CD247, ITGAL, ITGB2

[44] array · 8 items

[0]

M4047

[1]

Selective expression of chemokine receptors during T-cell polarization

[2]

6.08E − 04

[3]

3.12E − 03

[4]

1.75E − 02

[5]

9.37E − 02

[6]

[7]

CCR1, CCR5, IL18R1

[45] array · 8 items

[0]

M11358

[1]

Tumor Suppressor Arf Inhibits Ribosomal Biogenesis

[2]

4.24E − 03

[3]

1.28E − 02

[4]

7.19E − 02

[5]

6.53E − 01

[6]

[7]

ABL1, TP53

[46] array · 8 items

[0]

M17400

[1]

ALK in cardiac myocytes

[2]

1.93E − 02

[3]

4.37E − 02

[4]

2.45E − 01

[5]

1.00E + 00

[6]

[7]

CTNNB1, SMAD5

[47] array · 8 items

[0]

M5885

[1]

Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors

[2]

8.19E − 01

[3]

8.30E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

CLEC7A, SERPING1, CCL5

[48] array · 1 item

[0]

Panther DB

[49] array · 8 items

[0]

P00038

[1]

JAK/STAT signaling pathway

[2]

1.76E − 12

[3]

5.64E − 11

[4]

2.29E − 10

[5]

5.64E − 11

[6]

[7]

JAK1, JAK2, SOCS1, STAT1, STAT3, STAT4, STAT5B

[50] array · 8 items

[0]

P00031

[1]

Inflammation mediated by chemokine and cytokine signaling pathway

[2]

1.44E − 06

[3]

2.31E − 05

[4]

9.37E − 05

[5]

4.62E − 05

[6]

[7]

JAK2, CCRL2, CCR1, CCL5, CCR5, IKBKB, ITGAL, CX3CR1, STAT3

[51] array · 8 items

[0]

P00054

[1]

Toll receptor signaling pathway

[2]

1.94E − 04

[3]

1.03E − 03

[4]

4.19E − 03

[5]

6.20E − 03

[6]

[7]

TRAF6, IKBKE, TLR2, IKBKB

[52] array · 8 items

[0]

P00006

[1]

Apoptosis signaling pathway

[2]

3.03E − 04

[3]

1.39E − 03

[4]

5.62E − 03

[5]

9.69E − 03

[6]

[7]

TRAF2, GZMB, IKBKB, MAP4K2, TP53

[53] array · 8 items

[0]

P00010

[1]

B cell activation

[2]

4.43E − 02

[3]

9.45E − 02

[4]

3.83E − 01

[5]

1.00E + 00

[6]

[7]

HRAS, IKBKB

[54] array · 8 items

[0]

P00052

[1]

TGF-beta signaling pathway

[2]

9.73E − 02

[3]

1.67E − 01

[4]

6.78E − 01

[5]

1.00E + 00

[6]

[7]

HRAS, SMAD5

[55] array · 8 items

[0]

P00011

[1]

Blood coagulation

[2]

2.07E − 01

[3]

2.89E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

GP1BB

[56] array · 8 items

[0]

P00012

[1]

Cadherin signaling pathway

[2]

2.34E − 01

[3]

3.00E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

CTNNB1, FYN

[57] array · 8 items

[0]

P00057

[1]

Wntsignaling pathway

[2]

2.59E − 01

[3]

3.07E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

CTNNB1, TP53, SMAD5

[58] array · 8 items

[0]

P00056

[1]

VEGF signaling pathway

[2]

2.86E − 01

[3]

3.27E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

HRAS

[59] array · 1 item

[0]

Pathway Ontology

[60] array · 8 items

[0]

PW:0000125

[1]

G protein signaling

[2]

5.82E − 03

[3]

3.10E − 02

[4]

1.26E − 01

[5]

1.86E − 01

[6]

[7]

LTB4R

[61] array · 8 items

[0]

PW:0000297

[1]

platelet-derived growth factor signaling

[2]

5.82E − 03

[3]

3.10E − 02

[4]

1.26E − 01

[5]

1.86E − 01

[6]

[7]

JAK2

[62] array · 8 items

[0]

PW:0000143

[1]

insulin signaling

[2]

1.05E − 02

[3]

3.36E − 02

[4]

1.36E − 01

[5]

3.37E − 01

[6]

[7]

SOCS1, STAT5B

[63] array · 8 items

[0]

PW:0000330

[1]

Bone morphogenetic proteins signaling

[2]

2.86E − 02

[3]

6.53E − 02

[4]

2.65E − 01

[5]

9.15E − 01

[6]

[7]

SMAD5

[64] array · 8 items

[0]

PW:0000599

[1]

altered canonical Wntsignaling

[2]

2.86E − 02

[3]

6.53E − 02

[4]

2.65E − 01

[5]

9.15E − 01

[6]

[7]

CTNNB1

[65] array · 8 items

[0]

PW:0000508

[1]

platelet aggregation

[2]

3.42E − 02

[3]

6.84E − 02

[4]

2.78E − 01

[5]

1.00E + 00

[6]

[7]

GP1BB

[66] array · 8 items

[0]

PW:0000234

[1]

innate immune response

[2]

6.18E − 02

[3]

1.10E − 01

[4]

4.46E − 01

[5]

1.00E + 00

[6]

[7]

TLR2

[67] array · 8 items

[0]

PW:0000278

[1]

autophagy

[2]

1.04E − 01

[3]

1.39E − 01

[4]

5.65E − 01

[5]

1.00E + 00

[6]

[7]

ATG10

[68] array · 8 items

[0]

PW:0000243

[1]

vascular endothelial growth factor signaling

[2]

1.30E − 01

[3]

1.49E − 01

[4]

6.03E − 01

[5]

1.00E + 00

[6]

[7]

FYN

[69] array · 8 items

[0]

PW:0000490

[1]

transforming growth factor-beta Smad dependent signaling

[2]

1.40E − 01

[3]

1.55E − 01

[4]

6.28E − 01

[5]

1.00E + 00

[6]

[7]

RUNX1

[70] array · 1 item

[0]

SMPDB

[71] array · 8 items

[0]

SMP00320

[1]

Intracellular Signalling Through Adenosine Receptor A2a and Adenosine

[2]

1.55E − 02

[3]

2.46E − 02

[4]

4.52E − 02

[5]

4.65E − 02

[6]

[7]

HRAS, IKBKB

[72] array · 8 items

[0]

SMP00391

[1]

Insulin Signalling

[2]

1.89E − 01

[3]

1.89E − 01

[4]

3.46E − 01

[5]

5.66E − 01

[6]

[7]

HRAS

row_count

column_count

numeric_cells

420

header_rows

locator

section[13]/table-wrap[1]#Tab2

[12] object · 16 fields

asset:table:pmid:33251083:11

role

table

format

jats-table

media_type

application/vnd.jats.table+json

uri

null

sha256

sha256:307d19ecb0dfe452f834715a6c814a8c922a41eba5ff771952acf5734e1660b5

bytes

17321

access

open

state

verified

reader

read_table

reader_status

available

identifier

section[13]/table-wrap[2]#Tab3

version

null

note

The enriched pathway terms of the down regulated differentially expressed genes

structure object · 5 fields

pmcid

PMC7679428

section_index

section_title

Pathway enrichment analysis for DEGs

row_count

column_count

table object · 8 fields

label

Table 3

caption

The enriched pathway terms of the down regulated differentially expressed genes

rows array · 91 items

[0] array · 8 items

[0]

BIOCYC

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[1] array · 8 items

[0]

Pathway ID

[1]

Pathway Name

[2]

P-value

[3]

FDR B&H

[4]

FDR B&Y

[5]

Bonferroni

[6]

Gene Count

[7]

Gene

[2] array · 8 items

[0]

703092

[1]

Citrulline-nitric oxide cycle

[2]

8.83E − 02

[3]

2.53E − 01

[4]

8.24E − 01

[5]

1.00E + 00

[6]

[7]

NOS2

[3] array · 8 items

[0]

142419

[1]

Phospholipases

[2]

9.82E − 02

[3]

2.53E − 01

[4]

8.24E − 01

[5]

1.00E + 00

[6]

[7]

PLA2G2E, PLA2G2A

[4] array · 8 items

[0]

545273

[1]

Glycoaminoglycan-protein linkage region biosynthesis

[2]

1.05E − 01

[3]

2.53E − 01

[4]

8.24E − 01

[5]

1.00E + 00

[6]

[7]

B3GAT1

[5] array · 8 items

[0]

545323

[1]

Urate biosynthesis/inosine 5′-phosphate degradation

[2]

1.05E − 01

[3]

2.53E − 01

[4]

8.24E − 01

[5]

1.00E + 00

[6]

[7]

NT5E

[6] array · 8 items

[0]

142383

[1]

Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde

[2]

1.21E − 01

[3]

2.53E − 01

[4]

8.24E − 01

[5]

1.00E + 00

[6]

[7]

IDO1

[7] array · 8 items

[0]

KEGG

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8] array · 8 items

[0]

83051

[1]

Cytokine-cytokine receptor interaction

[2]

3.05E − 61

[3]

5.54E − 59

[4]

3.21E − 58

[5]

5.54E − 59

[6]

[7]

[9] array · 8 items

[0]

83078

[1]

Hematopoietic cell lineage

[2]

4.22E − 35

[3]

3.84E − 33

[4]

2.22E − 32

[5]

7.67E − 33

[6]

[7]

[10] array · 8 items

[0]

842771

[1]

Inflammatory bowel disease (IBD)

[2]

4.58E − 32

[3]

2.78E − 30

[4]

1.61E − 29

[5]

8.34E − 30

[6]

[7]

[11] array · 8 items

[0]

83077

[1]

Jak-STAT signaling pathway

[2]

4.56E − 26

[3]

1.19E − 24

[4]

6.86E − 24

[5]

8.30E − 24

[6]

[7]

[12] array · 8 items

[0]

213780

[1]

Tuberculosis

[2]

3.41E − 25

[3]

6.89E − 24

[4]

3.99E − 23

[5]

6.20E − 23

[6]

[7]

[13] array · 8 items

[0]

83120

[1]

Asthma

[2]

4.56E − 24

[3]

8.30E − 23

[4]

4.80E − 22

[5]

8.30E − 22

[6]

[7]

IL10, IL13, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, FCER1A, CCL11, CD40, IL3, IL4, IL5, IL9

[14] array · 8 items

[0]

125138

[1]

Viral myocarditis

[2]

2.26E − 16

[3]

2.06E − 15

[4]

1.19E − 14

[5]

4.12E − 14

[6]

[7]

HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, CD55, BID, CASP3, CD80, CD86, CD40

[15] array · 8 items

[0]

373901

[1]

HTLV-I infection

[2]

2.85E − 15

[3]

2.35E − 14

[4]

1.36E − 13

[5]

5.18E − 13

[6]

[7]

[16] array · 8 items

[0]

213306

[1]

Measles

[2]

4.04E − 12

[3]

2.53E − 11

[4]

1.47E − 10

[5]

7.35E − 10

[6]

[7]

IL12A, IL12B, IL13, CD46, TNFRSF10C, CD209, STAT5A, FCGR2B, RELA, TLR9, IFNA2, IFNAR1, IFNB1, IFNG, CD3E, IRAK4, IL2, IL4, IL6

[17] array · 8 items

[0]

83074

[1]

Antigen processing and presentation

[2]

7.12E − 12

[3]

4.32E − 11

[4]

2.50E − 10

[5]

1.30E − 09

[6]

[7]

HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, IFNG, CD8A, CD74, CTSS

[18] array · 8 items

[0]

217173

[1]

Influenza A

[2]

4.98E − 11

[3]

2.75E − 10

[4]

1.59E − 09

[5]

9.07E − 09

[6]

[7]

IL12A, IL12B, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1,HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, TNFRSF10C, RELA, IFNA2, IFNAR1, IFNB1, IFNG, IRAK4, MAPK11, IL6

[19] array · 8 items

[0]

Pathway interaction database

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[20] array · 8 items

[0]

137933

[1]

IL4-mediated signaling events

[2]

7.74E − 16

[3]

8.36E − 14

[4]

4.40E − 13

[5]

8.36E − 14

[6]

[7]

IL10, IL13RA1, CEBPB, AICDA, ETS1, CCL26, STAT5A, STAT6, PTPN6, PIGR, CCL11, THY1, EGR2, LTA, IL4, IL4R, IL5

[21] array · 8 items

[0]

137922

[1]

IL12-mediated signaling events

[2]

9.23E − 15

[3]

4.99E − 13

[4]

2.62E − 12

[5]

9.97E − 13

[6]

[7]

IL12A, IL12B, HLA-DRA, HLA-DRB1, STAT5A, STAT6, EOMES, NOS2, RELA, RELB, LCK, IFNG, CD3E, CD8A, IL2, IL4

[22] array · 8 items

[0]

138000

[1]

IL23-mediated signaling events

[2]

1.32E − 12

[3]

4.75E − 11

[4]

2.50E − 10

[5]

1.42E − 10

[6]

[7]

IL12B, IL17A, IL17F, STAT5A, NOS2, IL19, RELA, IL23A, IFNG, CD3E, IL2, IL6

[23] array · 8 items

[0]

137929

[1]

IL27-mediated signaling events

[2]

1.43E − 11

[3]

3.87E − 10

[4]

2.04E − 09

[5]

1.55E − 09

[6]

[7]

IL12A, IL12B, IL17A, GATA3, STAT5A, IFNG, EBI3, IL2, IL6, IL27

[24] array · 8 items

[0]

138058

[1]

BCR signaling pathway

[2]

3.00E − 07

[3]

4.05E − 06

[4]

2.13E − 05

[5]

3.24E − 05

[6]

[7]

ETS1, PTPN6, FCGR2B, BTK, POU2F2, RELA, CD19, CD22, CD79A, CD79B

[25] array · 8 items

[0]

138055

[1]

TCR signaling in naive CD8 + T cells

[2]

2.28E − 04

[3]

1.30E − 03

[4]

6.82E − 03

[5]

2.46E − 02

[6]

[7]

PTPN6, LCK, CD3E, CD8A, CD80, CD86

[26] array · 8 items

[0]

137939

[1]

Direct p53 effectors

[2]

2.95E − 03

[3]

1.33E − 02

[4]

7.00E − 02

[5]

3.18E − 01

[6]

[7]

SPP1, BCL2, TNFRSF10C, BID, CD82, MAP4K4, CX3CL1, LIF

[27] array · 8 items

[0]

138081

[1]

FAS (CD95) signaling pathway

[2]

3.67E − 03

[3]

1.42E − 02

[4]

7.46E − 02

[5]

3.97E − 01

[6]

[7]

BID, BTK, CASP3, MAPK11

[28] array · 8 items

[0]

137995

[1]

HIV-1 Nef: Negative effector of Fas and TNF-alpha

[2]

3.67E − 03

[3]

1.42E − 02

[4]

7.46E − 02

[5]

3.97E − 01

[6]

[7]

BCL2, BID, CASP3, RELA

[29] array · 8 items

[0]

137944

[1]

IL1-mediated signaling events

[2]

2.58E − 02

[3]

6.45E − 02

[4]

3.40E − 01

[5]

1.00E + 00

[6]

[7]

TOLLIP, RELA, IRAK4

[30] array · 8 items

[0]

REACTOME

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[31] array · 8 items

[0]

1269310

[1]

Cytokine Signaling in Immune system

[2]

3.81E − 46

[3]

2.02E − 43

[4]

1.39E − 42

[5]

2.02E − 43

[6]

[7]

[32] array · 8 items

[0]

1269318

[1]

Signaling by Interleukins

[2]

2.98E − 33

[3]

7.91E − 31

[4]

5.42E − 30

[5]

1.58E − 30

[6]

[7]

[33] array · 8 items

[0]

1269203

[1]

Innate Immune System

[2]

4.93E − 25

[3]

8.72E − 23

[4]

5.98E − 22

[5]

2.62E − 22

[6]

[7]

[34] array · 8 items

[0]

1269171

[1]

Adaptive Immune System

[2]

1.51E − 15

[3]

1.15E − 13

[4]

7.86E − 13

[5]

8.03E − 13

[6]

[7]

[35] array · 8 items

[0]

1269201

[1]

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

[2]

5.01E − 14

[3]

2.66E − 12

[4]

1.82E − 11

[5]

2.66E − 11

[6]

[7]

HLA-B, HLA-C, SLAMF6, FCGR2B, KLRB1, LILRB5, VCAM1, LILRA1, LILRA3, LILRA2, ICAM2, ICAM3, ICAM4, CD1A, CD3E, CD8A, CD19, CD22, ICAM5, CD34, CD40

[36] array · 8 items

[0]

1269546

[1]

Peptide ligand-binding receptors

[2]

6.17E − 08

[3]

1.82E − 06

[4]

1.25E − 05

[5]

3.27E − 05

[6]

[7]

CCR6, CCL13, CCR8, CCL16, CCL19, CCL20, CXCL11, XCL1, CX3CL1, CXCL12, CCR10, XCR1, CXCL13, PPBP, EDNRB, CXCR1, CXCR2

[37] array · 8 items

[0]

1269545

[1]

Class A/1 (Rhodopsin-like receptors)

[2]

4.71E − 07

[3]

1.14E − 05

[4]

7.79E − 05

[5]

2.50E − 04

[6]

[7]

PTAFR, PTGER4, CCR6, CCL13,CCR8,CCL16, CCL19, CCL20, CXCL11, XCL1, CX3CL1, CXCL12, CCR10, XCR1, CXCL13, GPR183, PPBP, S1PR1, EDNRB, CXCR1, CXCR2

[38] array · 8 items

[0]

1269340

[1]

Hemostasis

[2]

1.15E − 04

[3]

1.47E − 03

[4]

1.01E − 02

[5]

6.09E − 02

[6]

[7]

CD244, PDGFB, PECAM1, GATA3, PTK2, CFD, PTPN6, MIF, PLAU, NOS2, SELE, SELPLG, FN1, LCK, PPBP, IFNA2, IFNB1, CSF2, CSF2RB, CD9, CD44, CD48, CD74, IL2, IL3, IL5

[39] array · 8 items

[0]

1269501

[1]

MAPK family signaling cascades

[2]

3.27E − 04

[3]

3.40E − 03

[4]

2.33E − 02

[5]

1.74E − 01

[6]

[7]

PDGFB, PSMB10, PTK2, KIT, RAG1, RAG2, FN1, DUSP4, CSF2, CSF2RB, IL2, IL3, IL5, IL6, IL6R

[40] array · 8 items

[0]

1269240

[1]

Toll Like Receptor TLR6:TLR2 Cascade

[2]

3.46E − 04

[3]

3.40E − 03

[4]

2.33E − 02

[5]

1.84E − 01

[6]

[7]

MAPKAPK2, BTK, DUSP4, RELA, SIGIRR, TIRAP, IRAK4, MAPK11

[41] array · 8 items

[0]

Gen MAPP

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[42] array · 8 items

[0]

MAP00400

[1]

Phenylalanine tyrosine and tryptophan biosynthesis

[2]

1.38E − 01

[3]

5.02E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

BID

[43] array · 8 items

[0]

MAP_kinase_activity

[1]

MAP kinase activity

[2]

1.38E − 01

[3]

5.02E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

MAPK11

[44] array · 8 items

[0]

MAP00010

[1]

Glycolysis Gluconeogenesis

[2]

2.47E − 01

[3]

5.02E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

BID, GPI

[45] array · 8 items

[0]

MAP00030

[1]

Pentose phosphate

[2]

2.70E − 01

[3]

5.02E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

GPI

[46] array · 8 items

[0]

MAP00590

[1]

Prostaglandin and leukotriene metabolism

[2]

2.96E − 01

[3]

5.02E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

PLA2G2A

[47] array · 8 items

[0]

MAP00500

[1]

Starch and sucrose metabolism

[2]

3.34E − 01

[3]

5.02E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

GPI

[48] array · 8 items

[0]

MAP00330

[1]

Arginine and proline metabolism

[2]

5.05E − 01

[3]

5.81E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

NOS2

[49] array · 8 items

[0]

MAP00380

[1]

Tryptophan metabolism

[2]

5.73E − 01

[3]

5.81E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

IDO1

[50] array · 8 items

[0]

MAP00561

[1]

Glycerolipid metabolism

[2]

5.81E − 01

[3]

5.81E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

PLA2G2A

[51] array · 8 items

[0]

MSigDB C2 BIOCARTA (v6.0)

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[52] array · 8 items

[0]

M5883

[1]

Genes encoding secreted soluble factors

[2]

4.86E − 27

[3]

7.82E − 25

[4]

4.43E − 24

[5]

7.82E − 25

[6]

[7]

[53] array · 8 items

[0]

M17406

[1]

Cytokine Network

[2]

2.71E − 22

[3]

2.18E − 20

[4]

1.24E − 19

[5]

4.36E − 20

[6]

[7]

IL10, IL12A, IL12B, IL13, IL16, IL17A, IFNB1, IFNG, LTA, IL2, IL3, IL4, IL5, IL6, IL9

[54] array · 8 items

[0]

M6910

[1]

Cytokines and Inflammatory Response

[2]

5.19E − 21

[3]

2.78E − 19

[4]

1.58E − 18

[5]

8.35E − 19

[6]

[7]

IL10, IL12A, IL12B, IL13, HLA-DRA, HLA-DRB1, IFNB1, IFNG, CSF2, LTA, IL2, IL3, IL4, IL5, IL6, IL7

[55] array · 8 items

[0]

M5885

[1]

Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors

[2]

7.80E − 21

[3]

3.14E − 19

[4]

1.78E − 18

[5]

1.26E − 18

[6]

[7]

[56] array · 8 items

[0]

M5889

[1]

Ensemble of genes encoding extracellular matrix and extracellular matrix-associated proteins

[2]

4.62E − 17

[3]

1.49E − 15

[4]

8.43E − 15

[5]

7.44E − 15

[6]

[7]

[57] array · 8 items

[0]

M1467

[1]

The Co-Stimulatory Signal During T-cell Activation

[2]

4.81E − 11

[3]

7.03E − 10

[4]

3.98E − 09

[5]

7.74E − 09

[6]

[7]

HLA-DRA, HLA-DRB1, ICOSLG, LCK, CD3E, CD80, CD86, CTLA4, IL2

[58] array · 8 items

[0]

M3952

[1]

Cells and Molecules involved in local acute inflammatory response

[2]

1.02E − 05

[3]

7.46E − 05

[4]

4.22E − 04

[5]

1.64E − 03

[6]

[7]

C6, C7, VCAM1, SELPLG,IL6

[59] array · 8 items

[0]

M18215

[1]

Role of Tob in T-cell activation

[2]

3.16E − 05

[3]

2.21E − 04

[4]

1.25E − 03

[5]

5.08E − 03

[6]

[7]

IFNG, TGFBR1, CD3E, IL2, IL4

[60] array · 8 items

[0]

M13968

[1]

HIV-I Nef: negative effector of Fas and TNF

[2]

6.46E − 04

[3]

3.15E − 03

[4]

1.78E − 02

[5]

1.04E − 01

[6]

[7]

BCL2,PTK2, BID, CASP3, RELA, ARHGDIB

[61] array · 8 items

[0]

M13247

[1]

T Cytotoxic Cell Surface Molecules

[2]

1.90E − 03

[3]

6.80E − 03

[4]

3.85E − 02

[5]

3.06E − 01

[6]

[7]

CD3E, CD8A, THY1

[62] array · 8 items

[0]

Panther DB

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[63] array · 8 items

[0]

P00036

[1]

Interleukin signaling pathway

[2]

6.51E − 19

[3]

2.47E − 17

[4]

1.05E − 16

[5]

2.47E − 17

[6]

[7]

IL10,IL10RA, IL12A,IL13, IL13RA1, IL17A, MAPKAPK2, IL17F, STAT5A, STAT6, IL21, IL23A, IL2, IL4, IL4R, IL5, IL6, IL6R, IL7, CXCR1, IL9, CXCR2

[64] array · 8 items

[0]

P00031

[1]

Inflammation mediated by chemokine and cytokine signaling pathway

[2]

4.36E − 07

[3]

8.28E − 06

[4]

3.50E − 05

[5]

1.66E − 05

[6]

[7]

CCL26, CCL7, CCR6, CCL11, CCL13, CCR8, CCL18, CCL20, CCL22, CX3CL1, CCR10, XCR1, IFNAR1, IFNG, CXCR1, CXCR2

[65] array · 8 items

[0]

P00053

[1]

T cell activation

[2]

7.23E − 05

[3]

8.13E − 04

[4]

3.44E − 03

[5]

2.75E − 03

[6]

[7]

HLA-DPA1, HLA-DQA1, HLA-DRA, LCK, CD3E, CD80, CD86, CD74

[66] array · 8 items

[0]

P00010

[1]

B cell activation

[2]

8.56E − 05

[3]

8.13E − 04

[4]

3.44E − 03

[5]

3.25E − 03

[6]

[7]

PTPN6, BTK, CD19, CD22, CD79A, CD79B, MAPK11

[67] array · 8 items

[0]

P00054

[1]

Toll receptor signaling pathway

[2]

2.14E − 03

[3]

1.62E − 02

[4]

6.86E − 02

[5]

8.12E − 02

[6]

[7]

TOLLIP, RELA, TLR9, IFNB1, IRAK4

[68] array · 8 items

[0]

P00006

[1]

Apoptosis signaling pathway

[2]

2.67E − 03

[3]

1.69E − 02

[4]

7.14E − 02

[5]

1.01E − 01

[6]

[7]

BCL2, BID, BCL2L11, CASP3, RELA, RELB, LTA

[69] array · 8 items

[0]

P00035

[1]

Interferon-gamma signalingpathway

[2]

1.42E − 02

[3]

7.69E − 02

[4]

3.25E − 01

[5]

5.39E − 01

[6]

[7]

PTPN6, IFNG, MAPK11

[70] array · 8 items

[0]

P00046

[1]

Oxidative stress response

[2]

5.17E − 02

[3]

1.86E − 01

[4]

7.88E − 01

[5]

1.00E + 00

[6]

[7]

BCL2, DUSP4, MAPK11

[71] array · 8 items

[0]

P00047

[1]

PDGF signaling pathway

[2]

8.39E − 02

[3]

2.44E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

PDGFB, MAPKAPK2, ETS1, STAT5A, STAT6

[72] array · 8 items

[0]

P00034

[1]

Integrin signalling pathway

[2]

5.94E − 01

[3]

7.28E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

ITGAE, PTK2, FN1

[73] array · 8 items

[0]

Pathway Ontology

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[74] array · 8 items

[0]

PW:0000104

[1]

intrinsic apoptotic

[2]

1.82E − 03

[3]

7.63E − 02

[4]

3.30E − 01

[5]

7.63E − 02

[6]

[7]

BCL2, BID, BCL2L11, CASP3

[75] array · 8 items

[0]

PW:0000515

[1]

Interleukin-10 signaling

[2]

7.84E − 01

[3]

1.57E − 01

[4]

6.78E − 01

[5]

6.78E − 01

[6]

[7]

IL10

[76] array · 8 items

[0]

PW:0000516

[1]

Interleukin-6 signaling

[2]

7.84E − 01

[3]

1.57E − 01

[4]

6.78E − 01

[5]

6.78E − 01

[6]

[7]

IL6

[77] array · 8 items

[0]

PW:0000499

[1]

Nuclear Factor Kappa B signaling

[2]

9.58E − 01

[3]

1.60E − 01

[4]

6.91E − 01

[5]

6.91E − 01

[6]

[7]

RELA, RELB

[78] array · 8 items

[0]

PW:0000009

[1]

programmed cell death

[2]

1.00E + 00

[3]

1.80E − 01

[4]

7.78E − 01

[5]

7.78E − 01

[6]

[7]

BCL2, CASP3

[79] array · 8 items

[0]

PW:0000102

[1]

The extracellular signal-regulated RAF/MEK/ERK signaling

[2]

8.14E − 02

[3]

2.18E − 01

[4]

9.44E − 01

[5]

1.00E + 00

[6]

[7]

SPP1, S1PR1

[80] array · 8 items

[0]

PW:0000529

[1]

angiotensin (1-7) signaling

[2]

8.83E − 02

[3]

2.18E − 01

[4]

9.44E − 01

[5]

1.00E + 00

[6]

[7]

MME

[81] array · 8 items

[0]

PW:0000106

[1]

extrinsic apoptotic

[2]

1.05E − 01

[3]

2.45E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

CASP3

[82] array · 8 items

[0]

PW:0000559

[1]

hexosamine biosynthetic

[2]

1.21E − 01

[3]

2.55E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

GPI

[83] array · 8 items

[0]

PW:0000228

[1]

G protein signaling via Galphai family

[2]

1.53E − 01

[3]

2.80E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

S1PR1

[84] array · 8 items

[0]

SMPDB

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[85] array · 8 items

[0]

SMP00094

[1]

Sulindac Pathway

[2]

1.21E − 01

[3]

4.52E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

PLA2G2A

[86] array · 8 items

[0]

SMP00040

[1]

Glycolysis

[2]

2.14E − 01

[3]

4.52E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

GPI

[87] array · 8 items

[0]

SMP00063

[1]

Tryptophan Metabolism

[2]

2.70E − 01

[3]

4.52E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

IDO1

[88] array · 8 items

[0]

SMP00379

[1]

NifedipinePathway

[2]

2.83E − 01

[3]

4.52E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

EDNRB

[89] array · 8 items

[0]

SMP00006

[1]

Tyrosine Metabolism

[2]

3.59E − 01

[3]

4.84E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

MIF

[90] array · 8 items

[0]

SMP00320

[1]

Intracellular Signalling Through Adenosine Receptor A2a and Adenosine

[2]

4.57E − 01

[3]

4.84E − 01

[4]

1.00E + 00

[5]

1.00E + 00

[6]

[7]

MAPK11

row_count

column_count

numeric_cells

544

header_rows

locator

section[13]/table-wrap[2]#Tab3

[13] object · 16 fields

asset:table:pmid:33251083:12

role

table

format

jats-table

media_type

application/vnd.jats.table+json

uri

null

sha256

sha256:3d0cc2025b76ce360a2ebcd6f7a40ea02ca2add666d309680d150a2f033eabd0

bytes

8645

access

open

state

verified

reader

read_table

reader_status

available

identifier

section[14]/table-wrap[1]#Tab4

version

null

note

The enriched GO terms of the up regulated differentially expressed genes

structure object · 5 fields

pmcid

PMC7679428

section_index

section_title

Gene ontology (GO) enrichment analysis for DEGs

row_count

column_count

table object · 8 fields

label

Table 4

caption

The enriched GO terms of the up regulated differentially expressed genes

rows array · 31 items

[0] array · 9 items

[0]

GO ID

[1]

Category

[2]

GO Name

[3]

P Value

[4]

FDR B&H

[5]

FDR B&Y

[6]

Bonferroni

[7]

Gene Count

[8]

Gene

[1] array · 9 items

[0]

GO:0002682

[1]

[2]

Regulation of immune system process

[3]

1.87E − 103

[4]

9.66E − 100

[5]

8.82E − 99

[6]

9.66E − 100

[7]

153

[8]

[2] array · 9 items

[0]

GO:0019221

[1]

[2]

Cytokine-mediated signaling pathway

[3]

1.05E − 84

[4]

1.35E − 81

[5]

1.23E − 80

[6]

5.40E − 81

[7]

131

[8]

[3] array · 9 items

[0]

GO:0009607

[1]

[2]

RESPONSE to biotic stimulus

[3]

7.42E − 81

[4]

7.65E − 78

[5]

6.99E − 77

[6]

3.83E − 77

[7]

120

[8]

[4] array · 9 items

[0]

GO:0009607

[1]

[2]

Response to biotic stimulus

[3]

7.42E − 81

[4]

7.65E − 78

[5]

6.99E − 77

[6]

3.83E − 77

[7]

131

[8]

[5] array · 9 items

[0]

GO:0034097

[1]

[2]

Response to cytokine

[3]

3.04E − 80

[4]

2.61E − 77

[5]

2.39E − 76

[6]

1.57E − 76

[7]

120

[8]

IL10, IL10RA, IL12A, IL12B, IL13, IL13RA1, IRGM, IL16, TRAF3, TNFRSF9, IL17A, CEBPB, HLA-B, PDGFB, HLA-C, TNFSF12, SPP1, HLA-DPA1, HLA-DPB1, HLA-DQA1, MAPKAPK2, HLA-DQB1, HLA-DRA, HLA-DRB1, TNFRSF14, GATA3, ETS1, PSMB10, BCL2, PTAFR, IL1RL2, CCL26, IL17F, STAT5A, STAT6, TNFRSF4, PTPN6, IL22RA2, NFIL3, BTK, MIF, IL21, TOLLIP, CCL7, CCR6, CCL11, CCL13, CCR8, CCL15, MME, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, KIT, CX3CL1, NOS2, CXCL12, VCAM1, IL19, SELE, SELPLG, CCR10, XCR1, TCF7, ZEB1, FN1, IRF8, CXCL13, CASP3, RELA, RELB, PPBP, IL23A, S1PR1, IFNA2, TFRC, IFNAR1, IFNB1, IFNG, LIF, CSF1R, CSF2, CSF2RB, CSF3R, EBI3, EGR1, SIGIRR, IL20, CD80, CD86, TIRAP, IL22, CD40, IRAK4, CD44, TNFRSF13C, CD74, LTA, RORC, HAMP, MAPK11, IL1RAP, IL2, IL3, IL4, IL4R, IL5, IL6, IL6R, IL7, IL26, IL27, CXCR1, IL9, CXCR2

[6] array · 9 items

[0]

GO:0042110

[1]

[2]

T cell activation

[3]

8.30E − 63

[4]

2.25E − 60

[5]

2.06E − 59

[6]

4.28E − 59

[7]

[8]

[7] array · 9 items

[0]

GO:0001816

[1]

[2]

Cytokine production

[3]

8.07E − 58

[4]

1.81E − 55

[5]

1.65E − 54

[6]

4.16E − 54

[7]

[8]

[8] array · 9 items

[0]

GO:0002694

[1]

[2]

Regulation of leukocyte activation

[3]

7.07E − 57

[4]

1.52E − 54

[5]

1.39E − 53

[6]

3.65E − 53

[7]

[8]

[9] array · 9 items

[0]

GO:0006954

[1]

[2]

Inflammatory response

[3]

5.64E − 55

[4]

1.12E − 52

[5]

1.02E − 51

[6]

2.91E − 51

[7]

[8]

[10] array · 9 items

[0]

GO:0007155

[1]

[2]

Cell adhesion

[3]

3.87E − 42

[4]

3.50E − 40

[5]

3.20E − 39

[6]

2.00E − 38

[7]

[8]

[11] array · 9 items

[0]

GO:0009986

[1]

[2]

Cell surface

[3]

8.40E − 48

[4]

1.04E − 45

[5]

6.72E − 45

[6]

3.09E − 45

[7]

[8]

[12] array · 9 items

[0]

GO:0097478

[1]

[2]

Leaflet of membrane bilayer

[3]

8.80E − 48

[4]

1.04E − 45

[5]

6.72E − 45

[6]

3.24E − 45

[7]

[8]

[13] array · 9 items

[0]

GO:0031226

[1]

[2]

Intrinsic component of plasma membrane

[3]

4.10E − 24

[4]

3.01E − 22

[5]

1.96E − 21

[6]

1.51E − 21

[7]

[8]

[14] array · 9 items

[0]

GO:0098589

[1]

[2]

Membrane region

[3]

7.35E − 11

[4]

1.93E − 09

[5]

1.25E − 08

[6]

2.70E − 08

[7]

[8]

PECAM1, CD55, CD46, STAT6, FCER1A, BTK, MME, SELE, SELPLG, DPP4, ITLN1, CASP3, LCK, S1PR1, SLC2A1, EDNRB, TGFBR1, CD1A, CD8A, THY1, CD19, MS4A1, CD48, CD79A

[15] array · 9 items

[0]

GO:0043235

[1]

[2]

Receptor complex

[3]

3.10E − 10

[4]

6.71E − 09

[5]

4.35E − 08

[6]

1.14E − 07

[7]

[8]

IL12B, IL13RA1, TRAF3, ITGAE, PTPN6, PIGR, TOLLIP, KIT, ITLN1, CR2, TFRC, TGFBR1, CD3E, CSF1R, CD8A, CSF2RB, CSF3R, EBI3, CD40, CD44, CD74, CD79A, CD79B, IL4R, IL6, IL6R

[16] array · 9 items

[0]

GO:0030141

[1]

[2]

Secretory granule

[3]

3.67E − 07

[4]

5.20E − 06

[5]

3.37E − 05

[6]

1.35E − 04

[7]

[8]

PDGFB, CTSC, PECAM1, CD55, CD46, PTAFR, CFD, PTPN6, FCAR, PIGR, FCGR2A, MIF, PLA2G2A, TOLLIP, PLAU, MME, KIT, GPI, LILRA3, FN1, ATG7, PPBP, LGALS3, CD9, CD44, CD59, CTSS, CXCR1, CXCR2

[17] array · 9 items

[0]

GO:0005764

[1]

[2]

Lysosome

[3]

1.31E − 06

[4]

1.49E − 05

[5]

9.69E − 05

[6]

4.81E − 04

[7]

[8]

IL13, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, CTSC, HLA-DRB1, FCER1A, PIGR, BTK, TOLLIP,KIT, DPP4, TLR9, IFNAR1, CD34, CD74, IL4, IL4R, CTSS, CXCR2

[18] array · 9 items

[0]

GO:0005794

[1]

[2]

Golgi apparatus

[3]

4.18E − 03

[4]

2.00E − 02

[5]

1.30E − 01

[6]

1.00E + 00

[7]

[8]

[19] array · 9 items

[0]

GO:0048471

[1]

[2]

Perinuclear region of cytoplasm

[3]

2.87E − 02

[4]

8.46E − 02

[5]

5.49E − 01

[6]

1.00E + 00

[7]

[8]

TNFSF12, SPP1, PTPN22, BCL2, BTK, PLA2G2A, TOLLIP, CX3CL1, NOS2, SELE, ATG7,TFRC, TRAF4, BCAP31, CD34, CTLA4

[20] array · 9 items

[0]

GO:0044297

[1]

[2]

Cell body

[3]

9.03E − 02

[4]

2.08E − 01

[5]

1.00E + 00

[6]

1.00E + 00

[7]

[8]

PDGFB, MBP, PTGER4, FCGR2B, C4A, MME, CX3CL1, CASP3,IFNG, CD3E, THY1, CD22, CD40, IL6R

[21] array · 9 items

[0]

GO:0030054

[1]

[2]

Cell junction

[3]

9.70E − 02

[4]

2.20E − 01

[5]

1.00E + 00

[6]

1.00E + 00

[7]

[8]

PECAM1, CD46, PTK2, PTPN6, C4A, PLAU, MME, KIT, MAP4K4, DPP4, LCK, SLC2A1, TGFBR1, TRAF4, CD3E, THY1, CD9, CD44,CD59, HAMP, CDH5

[22] array · 9 items

[0]

GO:0005126

[1]

[2]

Cytokine receptor binding

[3]

8.37E − 54

[4]

6.01E − 51

[5]

4.30E − 50

[6]

6.01E − 51

[7]

[8]

[23] array · 9 items

[0]

GO:0005102

[1]

[2]

Signaling receptor binding

[3]

3.78E − 49

[4]

9.05E − 47

[5]

6.48E − 46

[6]

2.72E − 46

[7]

108

[8]

[24] array · 9 items

[0]

GO:0030545

[1]

[2]

Chemokine receptor binding

[3]

2.63E − 22

[4]

2.36E − 20

[5]

1.69E − 19

[6]

1.89E − 19

[7]

[8]

DEFB103B, CCL26, DEFB1, DEFB4A, CCL7, CCL11,CCL13, CCL15, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, CX3CL1, CXCL12, CXCL13, PPBP

[25] array · 9 items

[0]

GO:0098772

[1]

[2]

Molecular function regulator

[3]

1.42E − 18

[4]

6.80E − 17

[5]

4.86E − 16

[6]

1.02E − 15

[7]

[8]

[26] array · 9 items

[0]

GO:0004888

[1]

[2]

Transmembranesignaling receptor activity

[3]

2.09E − 12

[4]

8.81E − 11

[5]

6.31E − 10

[6]

1.50E − 09

[7]

[8]

[27] array · 9 items

[0]

GO:0001664

[1]

[2]

G protein-coupled receptor binding

[3]

3.80E − 12

[4]

1.52E − 10

[5]

1.08E − 09

[6]

2.73E − 09

[7]

[8]

DEFB103B, CCL26, DEFB1, DEFB4A, CCL7, CCL11, CCL13, CCL15, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, CX3CL1, CXCL12, CXCL13, PPBP, S1PR1, EDNRB, IL2

[28] array · 9 items

[0]

GO:0044877

[1]

[2]

Protein-containing complex binding

[3]

1.24E − 11

[4]

4.46E − 10

[5]

3.19E − 09

[6]

8.92E − 09

[7]

[8]

[29] array · 9 items

[0]

GO:0042802

[1]

[2]

IDENTICAL protein binding

[3]

1.81E − 07

[4]

3.93E − 06

[5]

2.81E − 05

[6]

1.30E − 04

[7]

[8]

[30] array · 9 items

[0]

GO:0046983

[1]

[2]

Protein dimerization activity

[3]

6.79E − 07

[4]

1.19E − 05

[5]

8.51E − 05

[6]

4.88E − 04

[7]

[8]

[31] array · 9 items

[0]

GO:0016301

[1]

[2]

Kinase activity

[3]

1.16E − 05

[4]

1.54E − 04

[5]

1.10E − 03

[6]

8.29E − 03

[7]

[8]

row_count

column_count

numeric_cells

217

header_rows

locator

section[14]/table-wrap[2]#Tab5

[15] object · 16 fields

asset:table:pmid:33251083:14

role

table

format

jats-table

media_type

application/vnd.jats.table+json

uri

null

sha256

sha256:72eaeba363b965fe7e952d91d5d134b882754beaa91740a8a3be9d2804db13fb

bytes

16979

access

open

state

verified

reader

read_table

reader_status

available

identifier

section[15]/table-wrap[1]#Tab6

version

null

note

Topology table for up and down regulated genes

structure object · 5 fields

pmcid

PMC7679428

section_index

section_title

PPI network construction and module analysis

row_count

277

column_count

table object · 8 fields

label

Table 6

caption

Topology table for up and down regulated genes

rows array · 277 items

[0] array · 7 items

[0]

Regulation

[1]

Node

[2]

Degree

[3]

Betweenness

[4]

Stress

[5]

Closeness

[6]

Clustering Coefficient

[1] array · 7 items

[0]

[1]

TP53

[2]

682

[3]

0.308256

[4]

69419762

[5]

0.44613

[6]

0.001042

[2] array · 7 items

[0]

[1]

HRAS

[2]

543

[3]

0.243425

[4]

36147274

[5]

0.454702

[6]

0.003568

[3] array · 7 items

[0]

[1]

CTNNB1

[2]

454

[3]

0.17049

[4]

60805652

[5]

0.403018

[6]

0.002042

[4] array · 7 items

[0]

[1]

FYN

[2]

396

[3]

0.117564

[4]

12570856

[5]

0.436236

[6]

0.010907

[5] array · 7 items

[0]

[1]

ABL1

[2]

362

[3]

0.118179

[4]

7631538

[5]

0.470883

[6]

0.015228

[6] array · 7 items

[0]

[1]

JAK2

[2]

258

[3]

0.054758

[4]

7164820

[5]

0.434802

[6]

0.021748

[7] array · 7 items

[0]

[1]

STAT3

[2]

253

[3]

0.05294

[4]

16470742

[5]

0.398767

[6]

0.02108

[8] array · 7 items

[0]

[1]

JAK1

[2]

223

[3]

0.032981

[4]

6336566

[5]

0.40235

[6]

0.019876

[9] array · 7 items

[0]

[1]

TRAF6

[2]

216

[3]

0.074546

[4]

12176648

[5]

0.395301

[6]

0.010207

[10] array · 7 items

[0]

[1]

STAT1

[2]

213

[3]

0.045072

[4]

12845532

[5]

0.387307

[6]

0.023031

[11] array · 7 items

[0]

[1]

TRAF2

[2]

171

[3]

0.047572

[4]

11238720

[5]

0.357837

[6]

0.007981

[12] array · 7 items

[0]

[1]

ZAP70

[2]

153

[3]

0.018814

[4]

3346658

[5]

0.375226

[6]

0.028294

[13] array · 7 items

[0]

[1]

IKBKB

[2]

140

[3]

0.040639

[4]

5153454

[5]

0.403521

[6]

0.017575

[14] array · 7 items

[0]

[1]

MX1

[2]

125

[3]

0.057134

[4]

6475242

[5]

0.352549

[6]

0.002194

[15] array · 7 items

[0]

[1]

STAT5B

[2]

118

[3]

0.012758

[4]

2934924

[5]

0.377415

[6]

0.057801

[16] array · 7 items

[0]

[1]

ZBTB16

[2]

105

[3]

0.029011

[4]

4339392

[5]

0.371064

[6]

0.00696

[17] array · 7 items

[0]

[1]

GP1BB

[2]

104

[3]

0.024662

[4]

2308816

[5]

0.350596

[6]

0.009335

[18] array · 7 items

[0]

[1]

RUNX1

[2]

[3]

0.021204

[4]

3579930

[5]

0.370309

[6]

0.010526

[19] array · 7 items

[0]

[1]

C1QBP

[2]

[3]

0.043687

[4]

7011558

[5]

0.334675

[6]

[20] array · 7 items

[0]

[1]

TLR2

[2]

[3]

0.019615

[4]

2401022

[5]

0.374839

[6]

0.034734

[21] array · 7 items

[0]

[1]

SOCS1

[2]

[3]

0.019595

[4]

1846156

[5]

0.398713

[6]

0.072829

[22] array · 7 items

[0]

[1]

SMAD5

[2]

[3]

0.024208

[4]

4462604

[5]

0.336687

[6]

0.003011

[23] array · 7 items

[0]

[1]

ITGB2

[2]

[3]

0.025976

[4]

3349086

[5]

0.351061

[6]

0.008607

[24] array · 7 items

[0]

[1]

IKZF1

[2]

[3]

0.011714

[4]

1722502

[5]

0.373157

[6]

0.034038

[25] array · 7 items

[0]

[1]

CCND3

[2]

[3]

0.025956

[4]

2361424

[5]

0.357661

[6]

0.008048

[26] array · 7 items

[0]

[1]

ATG5

[2]

[3]

0.020131

[4]

2294688

[5]

0.333219

[6]

0.00678

[27] array · 7 items

[0]

[1]

IFIH1

[2]

[3]

0.023459

[4]

2059722

[5]

0.333945

[6]

0.001753

[28] array · 7 items

[0]

[1]

STAT4

[2]

[3]

0.002561

[4]

797810

[5]

0.366902

[6]

0.082275

[29] array · 7 items

[0]

[1]

PSMB9

[2]

[3]

0.0248

[4]

2740768

[5]

0.310739

[6]

[30] array · 7 items

[0]

[1]

IKZF3

[2]

[3]

0.005026

[4]

756292

[5]

0.361346

[6]

0.053654

[31] array · 7 items

[0]

[1]

GFI1

[2]

[3]

0.007563

[4]

811180

[5]

0.357266

[6]

0.013527

[32] array · 7 items

[0]

[1]

IRF7

[2]

[3]

0.010411

[4]

1198488

[5]

0.338804

[6]

0.008457

[33] array · 7 items

[0]

[1]

MAP4K1

[2]

[3]

0.006432

[4]

851692

[5]

0.348957

[6]

0.046512

[34] array · 7 items

[0]

[1]

CD247

[2]

[3]

0.00724

[4]

710792

[5]

0.349292

[6]

0.058693

[35] array · 7 items

[0]

[1]

LCP2

[2]

[3]

0.003353

[4]

442356

[5]

0.338331

[6]

0.07439

[36] array · 7 items

[0]

[1]

CCR5

[2]

[3]

0.010719

[4]

942222

[5]

0.343359

[6]

0.043185

[37] array · 7 items

[0]

[1]

IRF5

[2]

[3]

0.006222

[4]

736764

[5]

0.339277

[6]

0.012478

[38] array · 7 items

[0]

[1]

GZMB

[2]

[3]

0.01009

[4]

1297184

[5]

0.313584

[6]

[39] array · 7 items

[0]

[1]

IL2RG

[2]

[3]

0.005284

[4]

347620

[5]

0.3463

[6]

0.071225

[40] array · 7 items

[0]

[1]

TBX21

[2]

[3]

0.003781

[4]

493896

[5]

0.328704

[6]

0.023715

[41] array · 7 items

[0]

[1]

XBP1

[2]

[3]

0.004344

[4]

440004

[5]

0.329933

[6]

[42] array · 7 items

[0]

[1]

HLA-A

[2]

[3]

0.007447

[4]

822622

[5]

0.311637

[6]

[43] array · 7 items

[0]

[1]

MAP4K2

[2]

[3]

0.002038

[4]

190802

[5]

0.334636

[6]

0.045752

[44] array · 7 items

[0]

[1]

CCR1

[2]

[3]

0.004542

[4]

722956

[5]

0.323912

[6]

0.019608

[45] array · 7 items

[0]

[1]

IFNAR2

[2]

[3]

0.003686

[4]

214358

[5]

0.335872

[6]

0.169118

[46] array · 7 items

[0]

[1]

ITGAL

[2]

[3]

0.004258

[4]

302784

[5]

0.285588

[6]

0.058824

[47] array · 7 items

[0]

[1]

ATG10

[2]

[3]

0.00303

[4]

204222

[5]

0.278618

[6]

0.075

[48] array · 7 items

[0]

[1]

CEACAM1

[2]

[3]

0.003567

[4]

815206

[5]

0.308991

[6]

[49] array · 7 items

[0]

[1]

CLEC7A

[2]

[3]

0.006223

[4]

422114

[5]

0.302253

[6]

[50] array · 7 items

[0]

[1]

CUL9

[2]

[3]

0.001917

[4]

66468

[5]

0.352806

[6]

0.111111

[51] array · 7 items

[0]

[1]

SERPING1

[2]

[3]

0.004857

[4]

805696

[5]

0.203225

[6]

[52] array · 7 items

[0]

[1]

NLRP3

[2]

[3]

0.002325

[4]

208526

[5]

0.304371

[6]

[53] array · 7 items

[0]

[1]

LTB4R

[2]

[3]

0.002812

[4]

970594

[5]

0.242059

[6]

[54] array · 7 items

[0]

[1]

GBP1

[2]

[3]

0.001571

[4]

66852

[5]

0.307489

[6]

[55] array · 7 items

[0]

[1]

LILRB2

[2]

[3]

0.004803

[4]

191694

[5]

0.287677

[6]

[56] array · 7 items

[0]

[1]

CD99

[2]

[3]

0.002792

[4]

99752

[5]

0.324129

[6]

[57] array · 7 items

[0]

[1]

KLRK1

[2]

[3]

0.003445

[4]

544176

[5]

0.26256

[6]

[58] array · 7 items

[0]

[1]

BST2

[2]

[3]

1.93E − 04

[4]

36836

[5]

0.324273

[6]

[59] array · 7 items

[0]

[1]

KLRD1

[2]

[3]

0.001389

[4]

97132

[5]

0.22517

[6]

0.047619

[60] array · 7 items

[0]

[1]

KLRC1

[2]

[3]

0.003221

[4]

307724

[5]

0.286234

[6]

0.1

[61] array · 7 items

[0]

[1]

IL18R1

[2]

[3]

0.00118

[4]

348338

[5]

0.245924

[6]

[62] array · 7 items

[0]

[1]

PDCD1

[2]

[3]

0.001374

[4]

55018

[5]

0.303894

[6]

0.166667

[63] array · 7 items

[0]

[1]

SLAMF7

[2]

[3]

0.00206

[4]

191070

[5]

0.233272

[6]

[64] array · 7 items

[0]

[1]

[2]

[3]

0.001446

[4]

96444

[5]

0.245447

[6]

[65] array · 7 items

[0]

[1]

IFI35

[2]

[3]

6.93E − 04

[4]

23710

[5]

0.323301

[6]

[66] array · 7 items

[0]

[1]

LAG3

[2]

[3]

4.23E − 06

[4]

1074

[5]

0.245695

[6]

[67] array · 7 items

[0]

[1]

IL18RAP

[2]

[3]

1.95E − 04

[4]

52194

[5]

0.233609

[6]

[68] array · 7 items

[0]

Down

[1]

MAPK11

[2]

421

[3]

0.179413

[4]

26118522

[5]

0.388195

[6]

0.003744

[69] array · 7 items

[0]

Down

[1]

RELA

[2]

285

[3]

0.126824

[4]

20931198

[5]

0.37804

[6]

0.004645

[70] array · 7 items

[0]

Down

[1]

LCK

[2]

267

[3]

0.108492

[4]

11305268

[5]

0.405534

[6]

0.014108

[71] array · 7 items

[0]

Down

[1]

KIT

[2]

221

[3]

0.051071

[4]

10158794

[5]

0.36783

[6]

0.015014

[72] array · 7 items

[0]

Down

[1]

EGR1

[2]

195

[3]

0.060886

[4]

6334914

[5]

0.384414

[6]

0.016178

[73] array · 7 items

[0]

Down

[1]

ILF3

[2]

179

[3]

0.093546

[4]

7805892

[5]

0.330116

[6]

3.14E − 04

[74] array · 7 items

[0]

Down

[1]

CASP3

[2]

175

[3]

0.070326

[4]

10842834

[5]

0.355181

[6]

0.005123

[75] array · 7 items

[0]

Down

[1]

PTK2

[2]

153

[3]

0.049652

[4]

8738870

[5]

0.356704

[6]

0.005246

[76] array · 7 items

[0]

Down

[1]

PTPN6

[2]

150

[3]

0.044684

[4]

5323296

[5]

0.365645

[6]

0.021477

[77] array · 7 items

[0]

Down

[1]

BCL2

[2]

150

[3]

0.062256

[4]

5772430

[5]

0.365862

[6]

0.009128

[78] array · 7 items

[0]

Down

[1]

BTK

[2]

137

[3]

0.022999

[4]

3449618

[5]

0.35359

[6]

0.019429

[79] array · 7 items

[0]

Down

[1]

STAT5A

[2]

126

[3]

0.024378

[4]

5096524

[5]

0.35745

[6]

0.027429

[80] array · 7 items

[0]

Down

[1]

TGFBR1

[2]

123

[3]

0.048955

[4]

6050368

[5]

0.349257

[6]

0.007464

[81] array · 7 items

[0]

Down

[1]

CSF1R

[2]

117

[3]

0.01327

[4]

3411424

[5]

0.344835

[6]

0.005894

[82] array · 7 items

[0]

Down

[1]

FN1

[2]

116

[3]

0.052141

[4]

5201654

[5]

0.335331

[6]

0.003148

[83] array · 7 items

[0]

Down

[1]

TCF4

[2]

115

[3]

0.044569

[4]

5794596

[5]

0.333586

[6]

0.005492

[84] array · 7 items

[0]

Down

[1]

TRAF3

[2]

113

[3]

0.038869

[4]

4088284

[5]

0.341886

[6]

0.010588

[85] array · 7 items

[0]

Down

[1]

STAT6

[2]

102

[3]

0.026319

[4]

3212830

[5]

0.363486

[6]

0.039216

[86] array · 7 items

[0]

Down

[1]

GATA3

[2]

[3]

0.03064

[4]

3006348

[5]

0.350689

[6]

0.018471

[87] array · 7 items

[0]

Down

[1]

IRAK4

[2]

[3]

0.015953

[4]

2526624

[5]

0.344064

[6]

0.010986

[88] array · 7 items

[0]

Down

[1]

TCF7

[2]

[3]

0.029254

[4]

4190222

[5]

0.323796

[6]

9.99E − 04

[89] array · 7 items

[0]

Down

[1]

ATG7

[2]

[3]

0.032475

[4]

4557368

[5]

0.323761

[6]

[90] array · 7 items

[0]

Down

[1]

PSMB10

[2]

[3]

0.037084

[4]

3948650

[5]

0.316536

[6]

[91] array · 7 items

[0]

Down

[1]

EGR2

[2]

[3]

0.014472

[4]

2942228

[5]

0.323966

[6]

0.002331

[92] array · 7 items

[0]

Down

[1]

CEBPB

[2]

[3]

0.01563

[4]

2080316

[5]

0.347208

[6]

0.028708

[93] array · 7 items

[0]

Down

[1]

TLR9

[2]

[3]

0.01613

[4]

2504516

[5]

0.335623

[6]

0.017658

[94] array · 7 items

[0]

Down

[1]

ETS1

[2]

[3]

0.015119

[4]

2229504

[5]

0.345493

[6]

0.023695

[95] array · 7 items

[0]

Down

[1]

MBP

[2]

[3]

0.02034

[4]

1946892

[5]

0.33211

[6]

0.008099

[96] array · 7 items

[0]

Down

[1]

CD40

[2]

[3]

0.012367

[4]

1565636

[5]

0.343144

[6]

0.030722

[97] array · 7 items

[0]

Down

[1]

PTPN22

[2]

[3]

0.005103

[4]

648768

[5]

0.333009

[6]

0.039939

[98] array · 7 items

[0]

Down

[1]

CXCL13

[2]

[3]

0.033409

[4]

4616616

[5]

0.255924

[6]

0.002644

[99] array · 7 items

[0]

Down

[1]

CD44

[2]

[3]

0.027234

[4]

2621678

[5]

0.352941

[6]

0.016393

[100] array · 7 items

[0]

Down

[1]

DUSP4

[2]

[3]

0.005964

[4]

877004

[5]

0.343106

[6]

0.046753

[101] array · 7 items

[0]

Down

[1]

TOLLIP

[2]

[3]

0.020841

[4]

1681614

[5]

0.32948

[6]

0.011448

[102] array · 7 items

[0]

Down

[1]

TRAF4

[2]

[3]

0.017367

[4]

1322968

[5]

0.327447

[6]

0.012579

[103] array · 7 items

[0]

Down

[1]

TFRC

[2]

[3]

0.020865

[4]

2030850

[5]

0.323932

[6]

7.84E − 04

[104] array · 7 items

[0]

Down

[1]

TAL1

[2]

[3]

0.012074

[4]

1294452

[5]

0.327273

[6]

0.02551

[105] array · 7 items

[0]

Down

[1]

BATF3

[2]

[3]

0.009925

[4]

1237560

[5]

0.309471

[6]

0.011525

[106] array · 7 items

[0]

Down

[1]

SKI

[2]

[3]

0.009912

[4]

1441494

[5]

0.325026

[6]

0.010176

[107] array · 7 items

[0]

Down

[1]

MAP4K4

[2]

[3]

0.00723

[4]

923942

[5]

0.334966

[6]

0.025121

[108] array · 7 items

[0]

Down

[1]

ARHGDIB

[2]

[3]

0.008007

[4]

998356

[5]

0.325267

[6]

0.00443

[109] array · 7 items

[0]

Down

[1]

BID

[2]

[3]

0.007734

[4]

665116

[5]

0.336026

[6]

0.046154

[110] array · 7 items

[0]

Down

[1]

BCL2L11

[2]

[3]

0.006742

[4]

718322

[5]

0.327935

[6]

0.032389

[111] array · 7 items

[0]

Down

[1]

NOS2

[2]

[3]

0.012743

[4]

915032

[5]

0.332218

[6]

0.010796

[112] array · 7 items

[0]

Down

[1]

AICDA

[2]

[3]

0.016444

[4]

2864544

[5]

0.288094

[6]

[113] array · 7 items

[0]

Down

[1]

GPI

[2]

[3]

0.009895

[4]

1400722

[5]

0.322202

[6]

[114] array · 7 items

[0]

Down

[1]

CSF2RB

[2]

[3]

0.005071

[4]

681430

[5]

0.345571

[6]

0.100601

[115] array · 7 items

[0]

Down

[1]

TIRAP

[2]

[3]

0.009595

[4]

1070880

[5]

0.324

[6]

0.033033

[116] array · 7 items

[0]

Down

[1]

CD9

[2]

[3]

0.01001

[4]

838100

[5]

0.302685

[6]

0.019048

[117] array · 7 items

[0]

Down

[1]

CDH5

[2]

[3]

0.00845

[4]

737334

[5]

0.306177

[6]

0.013445

[118] array · 7 items

[0]

Down

[1]

AIRE

[2]

[3]

0.010893

[4]

2140272

[5]

0.292753

[6]

[119] array · 7 items

[0]

Down

[1]

CD82

[2]

[3]

0.008605

[4]

911074

[5]

0.323659

[6]

0.020161

[120] array · 7 items

[0]

Down

[1]

IFNAR1

[2]

[3]

0.006943

[4]

536824

[5]

0.340902

[6]

0.062366

[121] array · 7 items

[0]

Down

[1]

CD3E

[2]

[3]

0.006779

[4]

602042

[5]

0.338614

[6]

0.078161

[122] array · 7 items

[0]

Down

[1]

LGALS3

[2]

[3]

0.009645

[4]

633882

[5]

0.302536

[6]

[123] array · 7 items

[0]

Down

[1]

VTN

[2]

[3]

0.009755

[4]

750034

[5]

0.299445

[6]

0.006897

[124] array · 7 items

[0]

Down

[1]

CD8A

[2]

[3]

0.008368

[4]

709958

[5]

0.334638

[6]

0.029557

[125] array · 7 items

[0]

Down

[1]

CSF3R

[2]

[3]

0.008229

[4]

711320

[5]

0.334093

[6]

0.029101

[126] array · 7 items

[0]

Down

[1]

EOMES

[2]

[3]

0.005201

[4]

513270

[5]

0.277597

[6]

0.018519

[127] array · 7 items

[0]

Down

[1]

VCAM1

[2]

[3]

0.008841

[4]

718322

[5]

0.31732

[6]

0.010582

[128] array · 7 items

[0]

Down

[1]

ZEB1

[2]

[3]

0.006122

[4]

1257304

[5]

0.288851

[6]

[129] array · 7 items

[0]

Down

[1]

MME

[2]

[3]

0.009061

[4]

1835908

[5]

0.290624

[6]

0.014245

[130] array · 7 items

[0]

Down

[1]

MIF

[2]

[3]

0.00826

[4]

611016

[5]

0.321596

[6]

0.005698

[131] array · 7 items

[0]

Down

[1]

IKZF2

[2]

[3]

0.003358

[4]

390862

[5]

0.3129

[6]

[132] array · 7 items

[0]

Down

[1]

MAPKAPK2

[2]

[3]

0.004801

[4]

451358

[5]

0.310909

[6]

0.024615

[133] array · 7 items

[0]

Down

[1]

PLAU

[2]

[3]

0.008975

[4]

593824

[5]

0.317844

[6]

0.01

[134] array · 7 items

[0]

Down

[1]

DPP4

[2]

[3]

0.010538

[4]

1418468

[5]

0.265231

[6]

0.006667

[135] array · 7 items

[0]

Down

[1]

RORC

[2]

[3]

0.00722

[4]

1661398

[5]

0.278729

[6]

0.013333

[136] array · 7 items

[0]

Down

[1]

CD55

[2]

[3]

0.010279

[4]

705586

[5]

0.303102

[6]

[137] array · 7 items

[0]

Down

[1]

IL4R

[2]

[3]

0.00238

[4]

270352

[5]

0.331181

[6]

0.083333

[138] array · 7 items

[0]

Down

[1]

CD19

[2]

[3]

0.001702

[4]

211728

[5]

0.304301

[6]

0.090909

[139] array · 7 items

[0]

Down

[1]

IRF8

[2]

[3]

0.005195

[4]

372574

[5]

0.329904

[6]

0.019763

[140] array · 7 items

[0]

Down

[1]

IL4

[2]

[3]

0.004905

[4]

441962

[5]

0.296246

[6]

0.019763

[141] array · 7 items

[0]

Down

[1]

RELB

[2]

[3]

0.003464

[4]

286340

[5]

0.326336

[6]

0.055336

[142] array · 7 items

[0]

Down

[1]

PAX5

[2]

[3]

0.002896

[4]

300204

[5]

0.291726

[6]

0.021645

[143] array · 7 items

[0]

Down

[1]

CXCR2

[2]

[3]

0.006344

[4]

1097670

[5]

0.26098

[6]

0.047619

[144] array · 7 items

[0]

Down

[1]

IL16

[2]

[3]

0.008141

[4]

455702

[5]

0.300821

[6]

[145] array · 7 items

[0]

Down

[1]

SPP1

[2]

[3]

0.005095

[4]

320668

[5]

0.307124

[6]

0.014286

[146] array · 7 items

[0]

Down

[1]

THY1

[2]

[3]

0.008614

[4]

468640

[5]

0.309285

[6]

0.004762

[147] array · 7 items

[0]

Down

[1]

SLC2A1

[2]

[3]

0.00547

[4]

544898

[5]

0.316244

[6]

[148] array · 7 items

[0]

Down

[1]

EDNRB

[2]

[3]

0.006473

[4]

488214

[5]

0.313729

[6]

[149] array · 7 items

[0]

Down

[1]

SELE

[2]

[3]

0.005852

[4]

411150

[5]

0.300615

[6]

0.031579

[150] array · 7 items

[0]

Down

[1]

HLA-DRA

[2]

[3]

0.004735

[4]

398954

[5]

0.319992

[6]

0.052288

[151] array · 7 items

[0]

Down

[1]

CD79A

[2]

[3]

0.00478

[4]

297512

[5]

0.338726

[6]

0.176471

[152] array · 7 items

[0]

Down

[1]

HLA-B

[2]

[3]

0.006176

[4]

428434

[5]

0.315111

[6]

0.022059

[153] array · 7 items

[0]

Down

[1]

BCAP31

[2]

[3]

0.005172

[4]

568664

[5]

0.289476

[6]

0.058824

[154] array · 7 items

[0]

Down

[1]

IL1RAP

[2]

[3]

0.003059

[4]

257852

[5]

0.322101

[6]

0.088235

[155] array · 7 items

[0]

Down

[1]

PDGFB

[2]

[3]

0.003308

[4]

533330

[5]

0.27399

[6]

[156] array · 7 items

[0]

Down

[1]

S1PR1

[2]

[3]

0.002256

[4]

404754

[5]

0.320025

[6]

[157] array · 7 items

[0]

Down

[1]

CD46

[2]

[3]

0.004006

[4]

360234

[5]

0.31814

[6]

0.047619

[158] array · 7 items

[0]

Down

[1]

RAG1

[2]

[3]

0.002698

[4]

229148

[5]

0.267304

[6]

0.019048

[159] array · 7 items

[0]

Down

[1]

CD22

[2]

[3]

0.003395

[4]

414458

[5]

0.289123

[6]

0.07619

[160] array · 7 items

[0]

Down

[1]

POU2F2

[2]

[3]

0.00252

[4]

256428

[5]

0.313506

[6]

[161] array · 7 items

[0]

Down

[1]

TNFRSF14

[2]

[3]

0.002863

[4]

205148

[5]

0.290131

[6]

0.054945

[162] array · 7 items

[0]

Down

[1]

FCGR2B

[2]

[3]

0.001419

[4]

233096

[5]

0.299854

[6]

0.087912

[163] array · 7 items

[0]

Down

[1]

CSF2

[2]

[3]

0.001964

[4]

189924

[5]

0.271764

[6]

0.076923

[164] array · 7 items

[0]

Down

[1]

SELPLG

[2]

[3]

0.004641

[4]

618406

[5]

0.266933

[6]

0.010989

[165] array · 7 items

[0]

Down

[1]

IL10

[2]

[3]

0.001286

[4]

131502

[5]

0.275387

[6]

0.025641

[166] array · 7 items

[0]

Down

[1]

CCL7

[2]

[3]

0.002891

[4]

346838

[5]

0.240789

[6]

[167] array · 7 items

[0]

Down

[1]

CD79B

[2]

[3]

3.06E − 04

[4]

78608

[5]

0.337796

[6]

0.423077

[168] array · 7 items

[0]

Down

[1]

HLA-C

[2]

[3]

0.003625

[4]

407006

[5]

0.310407

[6]

0.025641

[169] array · 7 items

[0]

Down

[1]

IL6R

[2]

[3]

0.004275

[4]

289876

[5]

0.288689

[6]

0.051282

[170] array · 7 items

[0]

Down

[1]

IL17A

[2]

[3]

0.002334

[4]

388710

[5]

0.280328

[6]

0.025641

[171] array · 7 items

[0]

Down

[1]

FCGR2A

[2]

[3]

0.002143

[4]

252800

[5]

0.318403

[6]

[172] array · 7 items

[0]

Down

[1]

LTA

[2]

[3]

0.002886

[4]

476206

[5]

0.257315

[6]

[173] array · 7 items

[0]

Down

[1]

CXCL12

[2]

[3]

0.005496

[4]

372448

[5]

0.27655

[6]

0.030303

[174] array · 7 items

[0]

Down

[1]

CTSS

[2]

[3]

0.00407

[4]

451030

[5]

0.260472

[6]

[175] array · 7 items

[0]

Down

[1]

CD59

[2]

[3]

0.004363

[4]

207460

[5]

0.290405

[6]

0.030303

[176] array · 7 items

[0]

Down

[1]

CXCR1

[2]

[3]

8.07E − 04

[4]

176404

[5]

0.242095

[6]

0.166667

[177] array · 7 items

[0]

Down

[1]

IL2

[2]

[3]

0.002493

[4]

217616

[5]

0.290487

[6]

0.030303

[178] array · 7 items

[0]

Down

[1]

[2]

[3]

9.26E − 04

[4]

133246

[5]

0.24911

[6]

[179] array · 7 items

[0]

Down

[1]

CD74

[2]

[3]

0.003192

[4]

267306

[5]

0.315369

[6]

0.121212

[180] array · 7 items

[0]

Down

[1]

CR2

[2]

[3]

0.001319

[4]

143504

[5]

0.267072

[6]

0.036364

[181] array · 7 items

[0]

Down

[1]

CCR10

[2]

[3]

0.003702

[4]

303034

[5]

0.222963

[6]

0.072727

[182] array · 7 items

[0]

Down

[1]

CTSC

[2]

[3]

0.004925

[4]

257558

[5]

0.302268

[6]

[183] array · 7 items

[0]

Down

[1]

TGFBI

[2]

[3]

7.77E − 04

[4]

51700

[5]

0.253167

[6]

0.155556

[184] array · 7 items

[0]

Down

[1]

CD209

[2]

[3]

4.47E − 04

[4]

37928

[5]

0.243628

[6]

0.044444

[185] array · 7 items

[0]

Down

[1]

NT5E

[2]

[3]

0.003249

[4]

169846

[5]

0.314627

[6]

0.022222

[186] array · 7 items

[0]

Down

[1]

IL10RA

[2]

[3]

0.001722

[4]

123836

[5]

0.32116

[6]

0.155556

[187] array · 7 items

[0]

Down

[1]

MBL2

[2]

[3]

0.002733

[4]

247190

[5]

0.248106

[6]

0.027778

[188] array · 7 items

[0]

Down

[1]

TNFRSF9

[2]

[3]

0.001065

[4]

77604

[5]

0.309005

[6]

0.305556

[189] array · 7 items

[0]

Down

[1]

HLA-DQA1

[2]

[3]

8.50E − 04

[4]

84902

[5]

0.306147

[6]

0.194444

[190] array · 7 items

[0]

Down

[1]

NFIL3

[2]

[3]

0.002148

[4]

269802

[5]

0.253063

[6]

[191] array · 7 items

[0]

Down

[1]

MS4A1

[2]

[3]

6.53E − 04

[4]

54246

[5]

0.308664

[6]

0.083333

[192] array · 7 items

[0]

Down

[1]

PTAFR

[2]

[3]

0.001839

[4]

146258

[5]

0.315401

[6]

0.055556

[193] array · 7 items

[0]

Down

[1]

MASP1

[2]

[3]

0.002137

[4]

326806

[5]

0.225528

[6]

0.083333

[194] array · 7 items

[0]

Down

[1]

PLA2G2A

[2]

[3]

0.002039

[4]

625578

[5]

0.228338

[6]

[195] array · 7 items

[0]

Down

[1]

TNFRSF4

[2]

[3]

7.20E − 04

[4]

87330

[5]

0.26198

[6]

0.321429

[196] array · 7 items

[0]

Down

[1]

IL13RA1

[2]

[3]

6.92E − 04

[4]

54632

[5]

0.3129

[6]

0.214286

[197] array · 7 items

[0]

Down

[1]

CD48

[2]

[3]

0.001004

[4]

75166

[5]

0.297881

[6]

0.142857

[198] array · 7 items

[0]

Down

[1]

CD244

[2]

[3]

0.001314

[4]

270208

[5]

0.265574

[6]

0.071429

[199] array · 7 items

[0]

Down

[1]

HLA-DRB1

[2]

[3]

0.001343

[4]

119046

[5]

0.273066

[6]

0.142857

[200] array · 7 items

[0]

Down

[1]

IL12A

[2]

[3]

0.003272

[4]

296440

[5]

0.241412

[6]

0.071429

[201] array · 7 items

[0]

Down

[1]

ICAM3

[2]

[3]

6.74E − 04

[4]

94610

[5]

0.255118

[6]

0.035714

[202] array · 7 items

[0]

Down

[1]

ICAM2

[2]

[3]

7.74E − 04

[4]

115578

[5]

0.242687

[6]

0.047619

[203] array · 7 items

[0]

Down

[1]

CD86

[2]

[3]

0.00143

[4]

76566

[5]

0.302417

[6]

0.190476

[204] array · 7 items

[0]

Down

[1]

IL6

[2]

[3]

0.001988

[4]

115352

[5]

0.260582

[6]

0.095238

[205] array · 7 items

[0]

Down

[1]

CD80

[2]

[3]

0.001335

[4]

74000

[5]

0.254317

[6]

0.190476

[206] array · 7 items

[0]

Down

[1]

CCL13

[2]

[3]

3.79E − 04

[4]

117758

[5]

0.239347

[6]

[207] array · 7 items

[0]

Down

[1]

CARD9

[2]

[3]

0.001358

[4]

152030

[5]

0.262583

[6]

[208] array · 7 items

[0]

Down

[1]

MASP2

[2]

[3]

8.34E − 04

[4]

73116

[5]

0.210649

[6]

0.2

[209] array · 7 items

[0]

Down

[1]

HLA-DMA

[2]

[3]

0.001965

[4]

186844

[5]

0.252792

[6]

0.2

[210] array · 7 items

[0]

Down

[1]

FCER1A

[2]

[3]

0.001958

[4]

462984

[5]

0.26283

[6]

[211] array · 7 items

[0]

Down

[1]

IL13

[2]

[3]

9.18E − 04

[4]

81904

[5]

0.260164

[6]

0.2

[212] array · 7 items

[0]

Down

[1]

PIGR

[2]

[3]

0.001383

[4]

46460

[5]

0.267211

[6]

[213] array · 7 items

[0]

Down

[1]

ICAM4

[2]

[3]

7.08E − 04

[4]

122662

[5]

0.244131

[6]

[214] array · 7 items

[0]

Down

[1]

CCL11

[2]

[3]

4.36E − 04

[4]

106892

[5]

0.239682

[6]

[215] array · 7 items

[0]

Down

[1]

FCAR

[2]

[3]

0.001325

[4]

60556

[5]

0.281404

[6]

0.066667

[216] array · 7 items

[0]

Down

[1]

PTGER4

[2]

[3]

0.001594

[4]

111600

[5]

0.311981

[6]

[217] array · 7 items

[0]

Down

[1]

RAG2

[2]

[3]

0.002235

[4]

108180

[5]

0.302893

[6]

0.133333

[218] array · 7 items

[0]

Down

[1]

PPBP

[2]

[3]

0.00149

[4]

101978

[5]

0.25057

[6]

0.066667

[219] array · 7 items

[0]

Down

[1]

IL3

[2]

[3]

1.42E − 05

[4]

4398

[5]

0.276848

[6]

0.133333

[220] array · 7 items

[0]

Down

[1]

HLA-DQB1

[2]

[3]

1.37E − 04

[4]

32052

[5]

0.304361

[6]

0.5

[221] array · 7 items

[0]

Down

[1]

IDO1

[2]

[3]

0.002598

[4]

124836

[5]

0.300263

[6]

[222] array · 7 items

[0]

Down

[1]

TNFRSF10C

[2]

[3]

6.74E − 04

[4]

112660

[5]

0.252006

[6]

[223] array · 7 items

[0]

Down

[1]

TNFRSF13C

[2]

[3]

6.50E − 04

[4]

58590

[5]

0.256308

[6]

0.3

[224] array · 7 items

[0]

Down

[1]

IL17F

[2]

[3]

2.32E − 04

[4]

81308

[5]

0.256031

[6]

0.2

[225] array · 7 items

[0]

Down

[1]

CFD

[2]

[3]

0.001535

[4]

135276

[5]

0.301765

[6]

[226] array · 7 items

[0]

Down

[1]

CCL19

[2]

[3]

8.76E − 05

[4]

9268

[5]

0.219387

[6]

0.4

[227] array · 7 items

[0]

Down

[1]

CD34

[2]

[3]

0.001329

[4]

226272

[5]

0.243224

[6]

[228] array · 7 items

[0]

Down

[1]

IFNG

[2]

[3]

0.001405

[4]

110736

[5]

0.270285

[6]

[229] array · 7 items

[0]

Down

[1]

IL23A

[2]

[3]

0.00132

[4]

310874

[5]

0.180846

[6]

0.1

[230] array · 7 items

[0]

Down

[1]

EBI3

[2]

[3]

0.001288

[4]

90012

[5]

0.222769

[6]

0.1

[231] array · 7 items

[0]

Down

[1]

C8B

[2]

[3]

2.59E − 04

[4]

21386

[5]

0.208212

[6]

0.166667

[232] array · 7 items

[0]

Down

[1]

CCL20

[2]

[3]

0.001697

[4]

215266

[5]

0.242974

[6]

[233] array · 7 items

[0]

Down

[1]

C4BPA

[2]

[3]

0.001305

[4]

202342

[5]

0.207217

[6]

[234] array · 7 items

[0]

Down

[1]

C8A

[2]

[3]

5.17E − 04

[4]

27442

[5]

0.225528

[6]

0.333333

[235] array · 7 items

[0]

Down

[1]

SLAMF6

[2]

[3]

6.38E − 06

[4]

766

[5]

0.274209

[6]

0.333333

[236] array · 7 items

[0]

Down

[1]

CCR6

[2]

[3]

0.001956

[4]

273648

[5]

0.209231

[6]

[237] array · 7 items

[0]

Down

[1]

BTLA

[2]

[3]

6.84E − 04

[4]

61880

[5]

0.275584

[6]

0.333333

[238] array · 7 items

[0]

Down

[1]

CCR8

[2]

[3]

6.64E − 04

[4]

48144

[5]

0.196954

[6]

[239] array · 7 items

[0]

Down

[1]

CXCL11

[2]

[3]

8.55E − 05

[4]

11782

[5]

0.220629

[6]

[240] array · 7 items

[0]

Down

[1]

SIGIRR

[2]

[3]

3.08E − 06

[4]

666

[5]

0.277147

[6]

0.333333

[241] array · 7 items

[0]

Down

[1]

ITLN1

[2]

[3]

0.001313

[4]

85710

[5]

0.272679

[6]

[242] array · 7 items

[0]

Down

[1]

ICAM5

[2]

[3]

3.97E − 05

[4]

5052

[5]

0.242936

[6]

[243] array · 7 items

[0]

Down

[1]

FCGRT

[2]

[3]

0.001307

[4]

236680

[5]

0.210779

[6]

[244] array · 7 items

[0]

Down

[1]

CCL22

[2]

[3]

5.04E − 04

[4]

43848

[5]

0.247169

[6]

[245] array · 7 items

[0]

Down

[1]

IL12B

[2]

[3]

1.64E − 04

[4]

39054

[5]

0.194859

[6]

0.5

[246] array · 7 items

[0]

Down

[1]

IL27

[2]

[3]

2.87E − 04

[4]

26194

[5]

0.215697

[6]

0.333333

[247] array · 7 items

[0]

Down

[1]

IL22

[2]

[3]

6.54E − 04

[4]

37474

[5]

0.199417

[6]

[248] array · 7 items

[0]

Down

[1]

[2]

[3]

1.54E − 04

[4]

29126

[5]

0.226657

[6]

[249] array · 7 items

[0]

Down

[1]

TIGIT

[2]

[3]

0.001299

[4]

79710

[5]

0.18742

[6]

[250] array · 7 items

[0]

Down

[1]

DEFB4A

[2]

[3]

0.002265

[4]

309432

[5]

0.250917

[6]

[251] array · 7 items

[0]

Down

[1]

IL22RA2

[2]

[3]

8.49E − 04

[4]

82918

[5]

0.216806

[6]

[252] array · 7 items

[0]

Down

[1]

IL21

[2]

[3]

2.06E − 05

[4]

882

[5]

0.21301

[6]

[253] array · 7 items

[0]

Down

[1]

[2]

[3]

1.97E − 05

[4]

976

[5]

0.229359

[6]

0.333333

[254] array · 7 items

[0]

Down

[1]

LIF

[2]

[3]

1.35E − 05

[4]

994

[5]

0.252689

[6]

[255] array · 7 items

[0]

Down

[1]

ITGAE

[2]

[3]

6.54E − 04

[4]

122018

[5]

0.226607

[6]

[256] array · 7 items

[0]

Down

[1]

IL5

[2]

[3]

2.60E − 05

[4]

1936

[5]

0.26283

[6]

0.333333

[257] array · 7 items

[0]

Down

[1]

HLA-DPB1

[2]

[3]

[4]

[5]

0.240356

[6]

[258] array · 7 items

[0]

Down

[1]

CFI

[2]

[3]

6.50E − 04

[4]

65960

[5]

0.196527

[6]

[259] array · 7 items

[0]

Down

[1]

IFNB1

[2]

[3]

[4]

[5]

0.254275

[6]

[260] array · 7 items

[0]

Down

[1]

IFNA2

[2]

[3]

[4]

[5]

0.254275

[6]

[261] array · 7 items

[0]

Down

[1]

XCL1

[2]

[3]

0.001299

[4]

97076

[5]

0.208706

[6]

[262] array · 7 items

[0]

Down

[1]

CD1A

[2]

[3]

6.50E − 04

[4]

79654

[5]

0.20475

[6]

[263] array · 7 items

[0]

Down

[1]

XCR1

[2]

[3]

6.50E − 04

[4]

48540

[5]

0.172698

[6]

[264] array · 7 items

[0]

Down

[1]

DEFB103B

[2]

[3]

6.50E − 04

[4]

91060

[5]

0.173057

[6]

[265] array · 7 items

[0]

Down

[1]

IL7

[2]

[3]

6.20E − 07

[4]

[5]

0.219497

[6]

[266] array · 7 items

[0]

Down

[1]

KLRB1

[2]

[3]

6.50E − 04

[4]

58078

[5]

0.267815

[6]

[267] array · 7 items

[0]

Down

[1]

IL20

[2]

[3]

0.666667

[4]

[5]

0.75

[6]

[268] array · 7 items

[0]

Down

[1]

HLA-DMB

[2]

[3]

[4]

[5]

0.201796

[6]

[269] array · 7 items

[0]

Down

[1]

HLA-DOB

[2]

[3]

[4]

[5]

0.16794

[6]

[270] array · 7 items

[0]

Down

[1]

ICOSLG

[2]

[3]

[4]

[5]

0.200469

[6]

[271] array · 7 items

[0]

Down

[1]

CD83

[2]

[3]

[4]

[5]

0.300029

[6]

[272] array · 7 items

[0]

Down

[1]

GPR183

[2]

[3]

[4]

[5]

0.300029

[6]

[273] array · 7 items

[0]

Down

[1]

IKBKAP

[2]

[3]

[4]

[5]

0.250938

[6]

[274] array · 7 items

[0]

Down

[1]

DEFB1

[2]

[3]

[4]

[5]

0.173038

[6]

[275] array · 7 items

[0]

Down

[1]

IL1RL2

[2]

[3]

[4]

[5]

0.20772

[6]

[276] array · 7 items

[0]

Down

[1]

IL19

[2]

[3]

[4]

[5]

0.5

[6]

row_count

277

column_count

numeric_cells

1443

header_rows

locator

section[15]/table-wrap[1]#Tab6

[16] object · 16 fields

asset:table:pmid:33251083:15

role

table

format

jats-table

media_type

application/vnd.jats.table+json

uri

null

sha256

sha256:9f3e4a1eac95f4caba623fab38d02663f148640b1982a308e2735b6d1ad0a952

bytes

10788

access

open

state

verified

reader

read_table

reader_status

available

identifier

section[16]/table-wrap[1]#Tab7

version

null

note

miRNA - target gene interaction table

structure object · 5 fields

pmcid

PMC7679428

section_index

section_title

Construction of target gene–miRNA regulatory network

row_count

185

column_count

table object · 8 fields

label

Table 7

caption

miRNA - target gene interaction table

rows array · 185 items

[0] array · 8 items

[0]

Regulation

[1]

Target Genes

[2]

Degree

[3]

MicroRNA

[4]

Regulation

[5]

Target Genes

[6]

Degree

[7]

MicroRNA

[1] array · 8 items

[0]

[1]

IKZF3

[2]

134

[3]

hsa-mir-6860

[4]

Down

[5]

SKI

[6]

210

[7]

hsa-mir-5100

[2] array · 8 items

[0]

[1]

TP53

[2]

130

[3]

hsa-mir-5703

[4]

Down

[5]

TNFRSF13C

[6]

136

[7]

hsa-mir-3197

[3] array · 8 items

[0]

[1]

IFNAR2

[2]

109

[3]

hsa-mir − 4510

[4]

Down

[5]

BCL2L11

[6]

122

[7]

hsa-mir-8064

[4] array · 8 items

[0]

[1]

SMAD5

[2]

[3]

hsa-mir-6086

[4]

Down

[5]

ICOSLG

[6]

119

[7]

hsa-mir-3672

[5] array · 8 items

[0]

[1]

STAT3

[2]

[3]

hsa-mir − 4270

[4]

Down

[5]

IL6R

[6]

[7]

hsa-mir-7641

[6] array · 8 items

[0]

[1]

TRAF6

[2]

[3]

hsa-mir-6745

[4]

Down

[5]

VCAM1

[6]

[7]

hsa-mir − 4270

[7] array · 8 items

[0]

[1]

RUNX1

[2]

[3]

hsa-mir − 4467

[4]

Down

[5]

LILRA2

[6]

[7]

hsa-mir − 4780

[8] array · 8 items

[0]

[1]

ABL1

[2]

[3]

hsa-mir − 4511

[4]

Down

[5]

IRAK4

[6]

[7]

hsa-mir-520e

[9] array · 8 items

[0]

[1]

KLRD1

[2]

[3]

hsa-mir-5094

[4]

Down

[5]

BTLA

[6]

[7]

hsa-mir-3133

[10] array · 8 items

[0]

[1]

CCL5

[2]

[3]

hsa-mir − 4775

[4]

Down

[5]

CD55

[6]

[7]

hsa-mir-6124

[11] array · 8 items

[0]

[1]

CTNNB1

[2]

[3]

hsa-mir − 4255

[4]

Down

[5]

CCL22

[6]

[7]

hsa-mir-5190

[12] array · 8 items

[0]

[1]

MAP4K2

[2]

[3]

hsa-mir-6131

[4]

Down

[5]

CD44

[6]

[7]

hsa-mir-5696

[13] array · 8 items

[0]

[1]

PSMB9

[2]

[3]

hsa-mir-3658

[4]

Down

[5]

PDGFB

[6]

[7]

hsa-mir-6132

[14] array · 8 items

[0]

[1]

ZBTB16

[2]

[3]

hsa-mir − 4287

[4]

Down

[5]

BCL2

[6]

[7]

hsa-mir-184

[15] array · 8 items

[0]

[1]

SOCS1

[2]

[3]

hsa-mir − 4495

[4]

Down

[5]

TFRC

[6]

[7]

hsa-mir-6070

[16] array · 8 items

[0]

[1]

HLA-A

[2]

[3]

hsa-mir-6129

[4]

Down

[5]

PIGR

[6]

[7]

hsa-mir − 4486

[17] array · 8 items

[0]

[1]

SERPING1

[2]

[3]

hsa-mir-1262

[4]

Down

[5]

CCL16

[6]

[7]

hsa-mir-7703

[18] array · 8 items

[0]

[1]

CCR5

[2]

[3]

hsa-mir-3183

[4]

Down

[5]

IFNAR1

[6]

[7]

hsa-mir − 4430

[19] array · 8 items

[0]

[1]

CLEC7A

[2]

[3]

hsa-mir − 4792

[4]

Down

[5]

TIRAP

[6]

[7]

hsa-mir − 4325

[20] array · 8 items

[0]

[1]

CD99

[2]

[3]

hsa-mir-3199

[4]

Down

[5]

ETS1

[6]

[7]

hsa-mir-3972

[21] array · 8 items

[0]

[1]

LILRB2

[2]

[3]

hsa-mir-3941

[4]

Down

[5]

CD59

[6]

[7]

hsa-mir-3919

[22] array · 8 items

[0]

[1]

ATG10

[2]

[3]

hsa-mir − 4309

[4]

Down

[5]

IKZF2

[6]

[7]

hsa-mir-5096

[23] array · 8 items

[0]

[1]

CCND3

[2]

[3]

hsa-mir-1321

[4]

Down

[5]

CEBPB

[6]

[7]

hsa-mir − 4510

[24] array · 8 items

[0]

[1]

STAT5B

[2]

[3]

hsa-mir-8485

[4]

Down

[5]

CD209

[6]

[7]

hsa-mir-3188

[25] array · 8 items

[0]

[1]

TRAF2

[2]

[3]

hsa-mir-6165

[4]

Down

[5]

HLA-C

[6]

[7]

hsa-mir − 4660

[26] array · 8 items

[0]

[1]

HRAS

[2]

[3]

hsa-mir-1268a

[4]

Down

[5]

DUSP4

[6]

[7]

hsa-mir-6089

[27] array · 8 items

[0]

[1]

STAT1

[2]

[3]

hsa-mir-1183

[4]

Down

[5]

CCR6

[6]

[7]

hsa-mir − 4539

[28] array · 8 items

[0]

[1]

JAK1

[2]

[3]

hsa-mir-107

[4]

Down

[5]

TGFBR1

[6]

[7]

hsa-mir-8083

[29] array · 8 items

[0]

[1]

CCRL2

[2]

[3]

hsa-mir − 4469

[4]

Down

[5]

MAPKAPK2

[6]

[7]

hsa-mir − 4468

[30] array · 8 items

[0]

[1]

ITGAL

[2]

[3]

hsa-mir-764

[4]

Down

[5]

SLC2A1

[6]

[7]

hsa-mir − 4448

[31] array · 8 items

[0]

[1]

FYN

[2]

[3]

hsa-mir-3924

[4]

Down

[5]

POU2F2

[6]

[7]

hsa-mir − 4307

[32] array · 8 items

[0]

[1]

JAK2

[2]

[3]

hsa-mir-5692a

[4]

Down

[5]

LIF

[6]

[7]

hsa-mir-3655

[33] array · 8 items

[0]

[1]

PDCD1

[2]

[3]

hsa-mir-922

[4]

Down

[5]

MBL2

[6]

[7]

hsa-mir-3689c

[34] array · 8 items

[0]

[1]

C1QBP

[2]

[3]

hsa-mir − 484

[4]

Down

[5]

HLA-B

[6]

[7]

hsa-mir-5047

[35] array · 8 items

[0]

[1]

IKBKB

[2]

[3]

hsa-mir − 451a

[4]

Down

[5]

ZEB1

[6]

[7]

hsa-mir-2113

[36] array · 8 items

[0]

[1]

TLR2

[2]

[3]

hsa-mir-105-5p

[4]

Down

[5]

RELA

[6]

[7]

hsa-mir-7515

[37] array · 8 items

[0]

[1]

XBP1

[2]

[3]

hsa-mir-320c

[4]

Down

[5]

CD46

[6]

[7]

hsa-mir − 4780

[38] array · 8 items

[0]

[1]

TMEM173

[2]

[3]

hsa-mir-5093

[4]

Down

[5]

PAX5

[6]

[7]

hsa-mir-6127

[39] array · 8 items

[0]

[1]

ATG5

[2]

[3]

hsa-mir-299-5p

[4]

Down

[5]

CASP3

[6]

[7]

hsa-mir − 4666b

[40] array · 8 items

[0]

[1]

ZAP70

[2]

[3]

hsa-mir-631

[4]

Down

[5]

STAT5A

[6]

[7]

hsa-mir − 4457

[41] array · 8 items

[0]

[1]

IFIH1

[2]

[3]

hsa-mir − 424-5p

[4]

Down

[5]

PTAFR

[6]

[7]

hsa-mir − 4301

[42] array · 8 items

[0]

[1]

KLRC1

[2]

[3]

hsa-mir-9-5p

[4]

Down

[5]

THY1

[6]

[7]

hsa-mir − 4269

[43] array · 8 items

[0]

[1]

IKZF1

[2]

[3]

hsa-mir-19a-3p

[4]

Down

[5]

ATG7

[6]

[7]

hsa-mir − 4518

[44] array · 8 items

[0]

[1]

KLRK1

[2]

[3]

hsa-mir-148b-3p

[4]

Down

[5]

S1PR1

[6]

[7]

hsa-mir-7977

[45] array · 8 items

[0]

[1]

IKBKE

[2]

[3]

hsa-mir-296-5p

[4]

Down

[5]

C8A

[6]

[7]

hsa-mir-1299

[46] array · 8 items

[0]

[1]

GFI1

[2]

[3]

hsa-mir-142-3p

[4]

Down

[5]

CDH5

[6]

[7]

hsa-mir-544a

[47] array · 8 items

[0]

[1]

NLRP3

[2]

[3]

hsa-mir-223-3p

[4]

Down

[5]

GPI

[6]

[7]

hsa-mir-760

[48] array · 8 items

[0]

[1]

ITGB2

[2]

[3]

hsa-mir-146a-5p

[4]

Down

[5]

ILF3

[6]

[7]

hsa-mir − 4314

[49] array · 8 items

[0]

[1]

IL18RAP

[2]

[3]

hsa-mir − 4677-3p

[4]

Down

[5]

KIT

[6]

[7]

hsa-mir − 4490

[50] array · 8 items

[0]

[1]

IRF7

[2]

[3]

hsa-mir-762

[4]

Down

[5]

GPR183

[6]

[7]

hsa-mir-1303

[51] array · 8 items

[0]

[1]

[2]

[3]

hsa-mir-335-5p

[4]

Down

[5]

TRAF3

[6]

[7]

hsa-mir-8085

[52] array · 8 items

[0]

[1]

MX1

[2]

[3]

hsa-mir-211-5p

[4]

Down

[5]

PTPN6

[6]

[7]

hsa-mir − 4525

[53] array · 8 items

[0]

[1]

CCR1

[2]

[3]

hsa-mir-181d-3p

[4]

Down

[5]

SELPLG

[6]

[7]

hsa-mir-1470

[54] array · 8 items

[0]

[1]

CUL9

[2]

[3]

hsa-mir-335-5p

[4]

Down

[5]

RAG1

[6]

[7]

hsa-mir-3666

[55] array · 8 items

[0]

[1]

IL18R1

[2]

[3]

hsa-mir-124-3p

[4]

Down

[5]

HLA-DRB1

[6]

[7]

hsa-mir-3978

[56] array · 8 items

[0]

[1]

GBP1

[2]

[3]

hsa-mir-124-3p

[4]

Down

[5]

TAL1

[6]

[7]

hsa-mir − 4719

[57] array · 8 items

[0]

[1]

TBX21

[2]

[3]

hsa-mir-29b-3p

[4]

Down

[5]

CCL11

[6]

[7]

hsa-mir-6077

[58] array · 8 items

[0]

[1]

GP1BB

[2]

[3]

hsa-mir-26b-5p

[4]

Down

[5]

IL6

[6]

[7]

hsa-mir − 451a

[59] array · 8 items

[0]

[1]

IRF5

[2]

[3]

hsa-mir-22-3p

[4]

Down

[5]

TGFBI

[6]

[7]

hsa-mir-1322

[60] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CTSS

[6]

[7]

hsa-mir-8066

[61] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CXCL12

[6]

[7]

hsa-mir-886-3p

[62] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

BID

[6]

[7]

hsa-mir-623

[63] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

TOLLIP

[6]

[7]

hsa-mir-6078

[64] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CD86

[6]

[7]

hsa-mir-8056

[65] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

TIGIT

[6]

[7]

hsa-mir-3941

[66] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CD3E

[6]

[7]

hsa-mir − 4510

[67] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

TNFRSF9

[6]

[7]

hsa-mir-1305

[68] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CXCR2

[6]

[7]

hsa-mir-588

[69] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

[6]

[7]

hsa-mir − 4310

[70] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL5

[6]

[7]

hsa-mir-604

[71] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

EBI3

[6]

[7]

hsa-mir-6069

[72] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

TCF4

[6]

[7]

hsa-let-7e-5p

[73] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

BCAP31

[6]

[7]

hsa-mir − 4514

[74] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CD82

[6]

[7]

hsa-mir-1470

[75] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

FCAR

[6]

[7]

hsa-mir-1976

[76] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

SELE

[6]

[7]

hsa-mir-630

[77] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

HLA-DRA

[6]

[7]

hsa-mir-3915

[78] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IFNB1

[6]

[7]

hsa-mir-6080

[79] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CD9

[6]

[7]

hsa-mir-5688

[80] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL10RA

[6]

[7]

hsa-mir-8064

[81] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL1RL2

[6]

[7]

hsa-mir − 4301

[82] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL1RAP

[6]

[7]

hsa-mir − 4635

[83] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL7

[6]

[7]

hsa-mir-203a-3p

[84] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CD19

[6]

[7]

hsa-mir − 466

[85] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IFNG

[6]

[7]

hsa-mir-15b-5p

[86] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

EGR2

[6]

[7]

hsa-mir-100-5p

[87] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

PTGER4

[6]

[7]

hsa-mir-101-3p

[88] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

C1S

[6]

[7]

hsa-mir-548 s

[89] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CX3CL1

[6]

[7]

hsa-mir-5093

[90] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CD244

[6]

[7]

hsa-mir-5702

[91] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

[6]

[7]

hsa-mir-1827

[92] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

PTK2

[6]

[7]

hsa-mir-543

[93] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

MS4A1

[6]

[7]

hsa-mir-644a

[94] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

AIRE

[6]

[7]

hsa-mir − 4770

[95] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

HLA-DOB

[6]

[7]

hsa-mir-1260a

[96] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

MAP4K4

[6]

[7]

hsa-mir-520e

[97] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

TRAF4

[6]

[7]

hsa-mir − 4284

[98] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

FN1

[6]

[7]

hsa-mir-200b-3p

[99] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

STAT6

[6]

[7]

hsa-mir-361-5p

[100] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CXCL11

[6]

[7]

hsa-mir − 4511

[101] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

EGR1

[6]

[7]

hsa-mir-377-3p

[102] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

C1R

[6]

[7]

hsa-mir-326

[103] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL10

[6]

[7]

hsa-mir-106a-5p

[104] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL12B

[6]

[7]

hsa-mir-103b

[105] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

PLAU

[6]

[7]

hsa-mir-23b-3p

[106] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

GATA3

[6]

[7]

hsa-mir-10b-5p

[107] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

FCGR2A

[6]

[7]

hsa-mir − 4275

[108] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

AICDA

[6]

[7]

hsa-mir-6873-3p

[109] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

NT5E

[6]

[7]

hsa-mir − 422a

[110] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CTLA4

[6]

[7]

hsa-mir-3924

[111] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

SPP1

[6]

[7]

hsa-mir-299-5p

[112] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

BTK

[6]

[7]

hsa-mir-1253

[113] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

MIF

[6]

[7]

hsa-mir-320a

[114] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL13

[6]

[7]

hsa-let-7i-5p

[115] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CD34

[6]

[7]

hsa-mir-106b-5p

[116] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL4

[6]

[7]

hsa-mir − 429

[117] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

RORC

[6]

[7]

hsa-mir-148b-3p

[118] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CTSC

[6]

[7]

hsa-mir-199a-5p

[119] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CD40

[6]

[7]

hsa-mir-503-5p

[120] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL2

[6]

[7]

hsa-mir-181c-5p

[121] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

TCF7

[6]

[7]

hsa-mir-22-3p

[122] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

ICAM5

[6]

[7]

hsa-mir − 4707-5p

[123] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CD83

[6]

[7]

hsa-mir-122-5p

[124] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

HLA-DQA1

[6]

[7]

hsa-mir − 4673

[125] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL4R

[6]

[7]

hsa-mir-331-3p

[126] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

MAPK11

[6]

[7]

hsa-let-7a-5p

[127] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

TNFSF12

[6]

[7]

hsa-mir-17-5p

[128] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CCL7

[6]

[7]

hsa-mir-135b-3p

[129] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL12A

[6]

[7]

hsa-mir-10a-5p

[130] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CSF1R

[6]

[7]

hsa-mir-155-5p

[131] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CFI

[6]

[7]

hsa-mir-181a-5p

[132] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL3

[6]

[7]

hsa-mir − 452-5p

[133] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

NFIL3

[6]

[7]

hsa-mir-183-5p

[134] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

ICAM3

[6]

[7]

hsa-mir-3943

[135] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

EOMES

[6]

[7]

hsa-mir-7855-5p

[136] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

PTPN22

[6]

[7]

hsa-mir-624-3p

[137] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

LGALS3

[6]

[7]

hsa-mir-744-5p

[138] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CCL19

[6]

[7]

hsa-mir-148b-3p

[139] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL17A

[6]

[7]

hsa-mir-16-1-3p

[140] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CD22

[6]

[7]

hsa-mir-19a-3p

[141] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CCL20

[6]

[7]

hsa-mir-21-5p

[142] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CCL26

[6]

[7]

hsa-mir-25-3p

[143] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

DEFB4A

[6]

[7]

hsa-mir-26b-5p

[144] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CXCR1

[6]

[7]

hsa-mir-335-5p

[145] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

MME

[6]

[7]

hsa-mir-1-3p

[146] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

VTN

[6]

[7]

hsa-mir-26b-5p

[147] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

LILRB5

[6]

[7]

hsa-mir-128-3p

[148] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL13RA1

[6]

[7]

hsa-mir-143-3p

[149] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

SIGIRR

[6]

[7]

hsa-mir-149-5p

[150] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

C14orf166

[6]

[7]

hsa-mir-331-3p

[151] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CD8A

[6]

[7]

hsa-mir-196b-5p

[152] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IRF8

[6]

[7]

hsa-mir-646

[153] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

FCGR2B

[6]

[7]

hsa-mir-18a-5p

[154] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

NOS2

[6]

[7]

hsa-mir-26a-5p

[155] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

RELB

[6]

[7]

hsa-mir-26b-5p

[156] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CXCL13

[6]

[7]

hsa-mir-26b-5p

[157] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

BATF3

[6]

[7]

hsa-mir-26b-5p

[158] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

ICAM4

[6]

[7]

hsa-mir-93-5p

[159] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL23A

[6]

[7]

hsa-mir-10a-5p

[160] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

ARHGDIB

[6]

[7]

hsa-mir-34a-5p

[161] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

LTA

[6]

[7]

hsa-mir-34a-5p

[162] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

ICAM2

[6]

[7]

hsa-mir-125b-5p

[163] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CR2

[6]

[7]

hsa-mir-132-3p

[164] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

B3GAT1

[6]

[7]

hsa-mir-132-3p

[165] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IDO1

[6]

[7]

hsa-mir-153-3p

[166] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

MASP1

[6]

[7]

hsa-mir-153-3p

[167] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CD80

[6]

[7]

hsa-mir-146a-5p

[168] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

HLA-DPA1

[6]

[7]

hsa-mir-155-5p

[169] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

TAGAP

[6]

[7]

hsa-mir-374a-5p

[170] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CD79A

[6]

[7]

hsa-mir-335-5p

[171] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

FCGRT

[6]

[7]

hsa-mir-335-5p

[172] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

HLA-DMA

[6]

[7]

hsa-mir-335-5p

[173] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

KLRB1

[6]

[7]

hsa-mir-335-5p

[174] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

LCK

[6]

[7]

hsa-mir-335-5p

[175] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

PPBP

[6]

[7]

hsa-mir-335-5p

[176] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CCL15

[6]

[7]

hsa-mir-335-5p

[177] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

CCL24

[6]

[7]

hsa-mir-335-5p

[178] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

LILRA1

[6]

[7]

hsa-mir-335-5p

[179] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

LILRA3

[6]

[7]

hsa-mir-335-5p

[180] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

PLA2G2E

[6]

[7]

hsa-mir-335-5p

[181] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL22

[6]

[7]

hsa-mir-335-5p

[182] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL27

[6]

[7]

hsa-mir-335-5p

[183] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

MBP

[6]

[7]

hsa-mir-127-5p

[184] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

IL20

[6]

[7]

hsa-mir-624-3p

row_count

185

column_count

numeric_cells

540

header_rows

locator

section[16]/table-wrap[1]#Tab7

[17] object · 16 fields

asset:table:pmid:33251083:16

role

table

format

jats-table

media_type

application/vnd.jats.table+json

uri

null

sha256

sha256:fc7eead614710882690059e1d793e3977d8f342b2ee037055408615b89dca16d

bytes

4208

access

open

state

verified

reader

read_table

reader_status

available

identifier

section[17]/table-wrap[1]#Tab8

version

null

note

TF—target gene interaction table

structure object · 5 fields

pmcid

PMC7679428

section_index

section_title

Construction of target gene–TF regulatory network

row_count

column_count

table object · 8 fields

label

Table 8

caption

TF—target gene interaction table

rows array · 75 items

[0] array · 8 items

[0]

Regulation

[1]

[2]

Degree

[3]

Target Gene

[4]

Regulation

[5]

[6]

Degree

[7]

Target Gene

[1] array · 8 items

[0]

[1]

FOXC1

[2]

[3]

JAK1

[4]

Down

[5]

FOXC1

[6]

127

[7]

KLRF2

[2] array · 8 items

[0]

[1]

GATA2

[2]

[3]

TRAF6

[4]

Down

[5]

GATA2

[6]

102

[7]

CD1A

[3] array · 8 items

[0]

[1]

YY1

[2]

[3]

CLEC7A

[4]

Down

[5]

YY1

[6]

[7]

TNFRSF4

[4] array · 8 items

[0]

[1]

CREB1

[2]

[3]

STAT1

[4]

Down

[5]

FOXL1

[6]

[7]

MME

[5] array · 8 items

[0]

[1]

TFAP2A

[2]

[3]

IKZF1

[4]

Down

[5]

NFKB1

[6]

[7]

CXCL12

[6] array · 8 items

[0]

[1]

PPARG

[2]

[3]

IRF7

[4]

Down

[5]

USF2

[6]

[7]

DEFB1

[7] array · 8 items

[0]

[1]

NFKB1

[2]

[3]

TRAF2

[4]

Down

[5]

SRF

[6]

[7]

STAT5A

[8] array · 8 items

[0]

[1]

E2F1

[2]

[3]

PSMB9

[4]

Down

[5]

CREB1

[6]

[7]

TNFRSF10C

[9] array · 8 items

[0]

[1]

RELA

[2]

[3]

IFI35

[4]

Down

[5]

TP53

[6]

[7]

C1S

[10] array · 8 items

[0]

[1]

USF2

[2]

[3]

LTB4R

[4]

Down

[5]

STAT3

[6]

[7]

IL26

[11] array · 8 items

[0]

[1]

SREBF1

[2]

[3]

CCND3

[4]

Down

[5]

PPARG

[6]

[7]

ICAM4

[12] array · 8 items

[0]

[1]

HINFP

[2]

[3]

GP1BB

[4]

Down

[5]

JUN

[6]

[7]

FCGRT

[13] array · 8 items

[0]

[1]

JUN

[2]

[3]

TLR2

[4]

Down

[5]

E2F1

[6]

[7]

GATA3

[14] array · 8 items

[0]

[1]

FOXL1

[2]

[3]

LCP2

[4]

Down

[5]

HINFP

[6]

[7]

BCL2L11

[15] array · 8 items

[0]

[1]

BRCA1

[2]

[3]

CD99

[4]

Down

[5]

TFAP2A

[6]

[7]

EOMES

[16] array · 8 items

[0]

[1]

NFIC

[2]

[3]

FYN

[4]

Down

[5]

NFIC

[6]

[7]

IFNA2

[17] array · 8 items

[0]

[1]

SRF

[2]

[3]

IL18RAP

[4]

Down

[5]

MEF2A

[6]

[7]

CTSS

[18] array · 8 items

[0]

[1]

GATA3

[2]

[3]

CX3CR1

[4]

Down

[5]

NFYA

[6]

[7]

GPI

[19] array · 8 items

[0]

[1]

PRDM1

[2]

[3]

GNLY

[4]

Down

[5]

TEAD1

[6]

[7]

LTA

[20] array · 8 items

[0]

[1]

POU2F2

[2]

[3]

SLAMF7

[4]

Down

[5]

HOXA5

[6]

[7]

PPBP

[21] array · 8 items

[0]

[1]

USF1

[2]

[3]

ATG5

[4]

Down

[5]

MAX

[6]

[7]

IL12B

[22] array · 8 items

[0]

[1]

FOS

[2]

[3]

CCL5

[4]

Down

[5]

SREBF2

[6]

[7]

CD80

[23] array · 8 items

[0]

[1]

TEAD1

[2]

[3]

CCR1

[4]

Down

[5]

SREBF1

[6]

[7]

DEFB4A

[24] array · 8 items

[0]

[1]

TFAP2C

[2]

[3]

CEACAM1

[4]

Down

[5]

JUND

[6]

[7]

HLA-DPB1

[25] array · 8 items

[0]

[1]

ELK4

[2]

[3]

GBP1

[4]

Down

[5]

TFAP2C

[6]

[7]

HLA-DQA1

[26] array · 8 items

[0]

[1]

HOXA5

[2]

[3]

GZMB

[4]

Down

[5]

RUNX2

[6]

[7]

C1R

[27] array · 8 items

[0]

[1]

E2F6

[2]

[3]

HRAS

[4]

Down

[5]

ARID3A

[6]

[7]

SKI

[28] array · 8 items

[0]

[1]

HNF4A

[2]

[3]

IFNAR2

[4]

Down

[5]

HNF4A

[6]

[7]

CR2

[29] array · 8 items

[0]

[1]

RUNX2

[2]

[3]

KLRK1

[4]

Down

[5]

ZNF354C

[6]

[7]

C8A

[30] array · 8 items

[0]

[1]

NFYA

[2]

[3]

ATG10

[4]

Down

[5]

NR3C1

[6]

[7]

FCGR2B

[31] array · 8 items

[0]

[1]

SREBF2

[2]

[3]

C1QBP

[4]

Down

[5]

IRF2

[6]

[7]

XCR1

[32] array · 8 items

[0]

[1]

MAX

[2]

[3]

CCRL2

[4]

Down

[5]

PRDM1

[6]

[7]

IL13

[33] array · 8 items

[0]

[1]

CEBPB

[2]

[3]

CD247

[4]

Down

[5]

FOS

[6]

[7]

CCL15

[34] array · 8 items

[0]

[1]

PRRX2

[2]

[3]

CTNNB1

[4]

Down

[5]

USF1

[6]

[7]

IRAK4

[35] array · 8 items

[0]

[1]

ZNF354C

[2]

[3]

GFI1

[4]

Down

[5]

FOXA1

[6]

[7]

ITLN1

[36] array · 8 items

[0]

[1]

MEF2A

[2]

[3]

IL18R1

[4]

Down

[5]

PRRX2

[6]

[7]

TLR9

[37] array · 8 items

[0]

[1]

ARID3A

[2]

[3]

ABL1

[4]

Down

[5]

STAT1

[6]

[7]

LCK

[38] array · 8 items

[0]

[1]

ESR1

[2]

[3]

[4]

Down

[5]

SP1

[6]

[7]

CD82

[39] array · 8 items

[0]

[1]

PDX1

[2]

[3]

HLA-A

[4]

Down

[5]

ELK4

[6]

[7]

PAX5

[40] array · 8 items

[0]

[1]

NR3C1

[2]

[3]

ITGAL

[4]

Down

[5]

NKX3-2

[6]

[7]

PLA2G2E

[41] array · 8 items

[0]

[1]

KLF5

[2]

[3]

ITGB2

[4]

Down

[5]

KLF5

[6]

[7]

ICOSLG

[42] array · 8 items

[0]

[1]

ELK1

[2]

[3]

JAK2

[4]

Down

[5]

ELK1

[6]

[7]

IDO1

[43] array · 8 items

[0]

[1]

SP1

[2]

[3]

MAP4K2

[4]

Down

[5]

BRCA1

[6]

[7]

LGALS3

[44] array · 8 items

[0]

[1]

EGR1

[2]

[3]

MX1

[4]

Down

[5]

ESR1

[6]

[7]

MASP2

[45] array · 8 items

[0]

[1]

EN1

[2]

[3]

SMAD5

[4]

Down

[5]

TP63

[6]

[7]

CD19

[46] array · 8 items

[0]

[1]

IRF2

[2]

[3]

RUNX1

[4]

Down

[5]

PAX2

[6]

[7]

CD48

[47] array · 8 items

[0]

[1]

PAX2

[2]

[3]

STAT5B

[4]

Down

[5]

NR2F1

[6]

[7]

CEBPB

[48] array · 8 items

[0]

[1]

NR2F1

[2]

[3]

CUL9

[4]

Down

[5]

E2F6

[6]

[7]

CD8A

[49] array · 8 items

[0]

[1]

FOXF2

[2]

[3]

IKBKE

[4]

Down

[5]

EN1

[6]

[7]

IL22

[50] array · 8 items

[0]

[1]

TP63

[2]

[3]

IKZF3

[4]

Down

[5]

SPIB

[6]

[7]

PTAFR

[51] array · 8 items

[0]

[1]

FOXA1

[2]

[3]

IL2RG

[4]

Down

[5]

FOXF2

[6]

[7]

SELE

[52] array · 8 items

[0]

[1]

NRF1

[2]

[3]

MAP4K1

[4]

Down

[5]

SOX10

[6]

[7]

POU2F2

[53] array · 8 items

[0]

[1]

JUND

[2]

[3]

NLRP3

[4]

Down

[5]

SRY

[6]

[7]

EDNRB

[54] array · 8 items

[0]

[1]

SPIB

[2]

[3]

ZBTB16

[4]

Down

[5]

NRF1

[6]

[7]

IFNAR1

[55] array · 8 items

[0]

[1]

REL

[2]

[3]

IKZF3

[4]

Down

[5]

SOX17

[6]

[7]

TNFRSF14

[56] array · 8 items

[0]

[1]

NKX3-1

[2]

[3]

IRF5

[4]

Down

[5]

SOX5

[6]

[7]

BTK

[57] array · 8 items

[0]

[1]

SOX5

[2]

[3]

KLRD1

[4]

Down

[5]

NKX2-5

[6]

[7]

PIGR

[58] array · 8 items

[0]

[1]

SOX10

[2]

[3]

STAT3

[4]

Down

[5]

ELF5

[6]

[7]

BATF3

[59] array · 8 items

[0]

[1]

MYB

[2]

[3]

JAK2

[4]

Down

[5]

NFATC2

[6]

[7]

IL4

[60] array · 8 items

[0]

[1]

SRY

[2]

[3]

KLRK1

[4]

Down

[5]

PDX1

[6]

[7]

ITGAE

[61] array · 8 items

[0]

[1]

ELF5

[2]

[3]

TLR2

[4]

Down

[5]

NFYB

[6]

[7]

PTPN6

[62] array · 8 items

[0]

[1]

NFIL3

[2]

[3]

CX3CR1

[4]

Down

[5]

ZFX

[6]

[7]

THY1

[63] array · 8 items

[0]

[1]

NR4A2

[2]

[3]

[4]

Down

[5]

NR4A2

[6]

[7]

CSF2

[64] array · 8 items

[0]

[1]

FEV

[2]

[3]

ATG5

[4]

Down

[5]

FEV

[6]

[7]

IL23A

[65] array · 8 items

[0]

[1]

FOXI1

[2]

[3]

CCL5

[4]

Down

[5]

MYB

[6]

[7]

MIF

[66] array · 8 items

[0]

[1]

NKX3-2

[2]

[3]

GZMB

[4]

Down

[5]

HNF1B

[6]

[7]

SPP1

[67] array · 8 items

[0]

[1]

E2F4

[2]

[3]

IKZF1

[4]

Down

[5]

REL

[6]

[7]

STAT6

[68] array · 8 items

[0]

[1]

TFCP2L1

[2]

[3]

LCP2

[4]

Down

[5]

ESR2

[6]

[7]

CCL22

[69] array · 8 items

[0]

[1]

NR2E3

[2]

[3]

HLA-A

[4]

Down

[5]

FOXI1

[6]

[7]

CD209

[70] array · 8 items

[0]

[1]

GATA1

[2]

[3]

HLA-A

[4]

Down

[5]

FOXD1

[6]

[7]

HLA-DOB

[71] array · 8 items

[0]

[1]

HNF1B

[2]

[3]

IL18R1

[4]

Down

[5]

ESRRB

[6]

[7]

ICAM2

[72] array · 8 items

[0]

[1]

SOX17

[2]

[3]

LILRA6

[4]

Down

[5]

NR2E3

[6]

[7]

IL2

[73] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

E2F4

[6]

[7]

S1PR1

[74] array · 8 items

[0]

[1]

[2]

[3]

[4]

Down

[5]

GATA1

[6]

[7]

PDGFB

row_count

column_count

numeric_cells

183

header_rows

locator

section[17]/table-wrap[1]#Tab8

gaps array · 2 items

[0]

asset:data:geo:E-MTAB-8871 not downloaded

[1]

asset:data:geo:E-MTAB-8871 licence not read

analysis object · 4 fields

state

complete

methods array · 2 items

[0] object · 10 fields

method-1

family

differential_expression

specific

limma_voom

label

Differential expression analysis

dsl_operations array · 3 items

[0]

normalise_counts

[1]

differential_expression_fit

[2]

fdr_bh

missing_operations array · 0 items

expressible

true

parameters object · 0 fields

data_shapes array · 1 item

[0]

count_matrix_with_condition

evidence object · 3 fields

score

band

verbatim

quote

The limma package in R Software was used for background correction, quantile normalization and probe summarization, and limma package was also applied for DEGs identification (Ritchie et al. 2015).

[1] object · 10 fields

method-2

family

network_analysis

specific

ppi_network

label

Network / pathway analysis

dsl_operations array · 3 items

[0]

build_graph

[1]

centrality_scores

[2]

pathway_enrich

missing_operations array · 0 items

expressible

true

parameters object · 0 fields

data_shapes array · 1 item

[0]

edge_list

evidence object · 3 fields

score

0.7

band

medium

quote

protein-protein interaction

targets array · 0 items

gaps array · 0 items

capability object · 3 fields

state

complete

requirements array · 1 item

[0] object · 6 fields

capability_id

capability:computational_analysis

label

Computational analysis platform

assay_families array · 9 items

[0]

meta_analysis

[1]

machine_learning

[2]

survival_analysis

[3]

statistical_regression

[4]

pca

[5]

molecular_docking

[6]

network_analysis

[7]

differential_expression

[8]

gwas

availability_state

owned

tier_unlocked

candidate

Automated Assays Laravel application and simulated adapters

gaps array · 0 items

readiness object · 8 fields

state

complete

tier

blocking_axis

none

blocked_on

nothing:replicable_now

axes object · 3 fields

method object · 5 fields

tier

expressible

true

required_operations array · 3 items

[0]

normalise_counts

[1]

differential_expression_fit

[2]

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s 2 (COVID-19) diagnosis and treatment using microarray dataset and bioinformatics methods.

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mechanisms of infection with SARS-CoV-2. The microarray data of the dataset E-MTAB-8871 were retriev

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Complete file

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The microarray data of the dataset E-MTAB-8871 were retrieved from the ArrayExpress database. Pathway and Gene Ontology (GO) enrichment study, protein-protein interaction (PPI) network, modules, target gene-miRNA regulatory network, and target gene-TF regulatory network have been performed. Subsequently, the key genes were validated using an analysis of the receiver operating characteristic (ROC) curve. In SARS-CoV-2 infection, a total of 324 DEGs (76 up- and 248 down-regulated genes) were identified and enriched in a number of associated SARS-CoV-2 infection pathways and GO terms. Hub and target genes such as TP53, HRAS, MAPK11, RELA, IKZF3, IFNAR2, SKI, TNFRSF13C, JAK1, TRAF6, KLRF2, CD1A were identified from PPI network, target gene-miRNA regulatory network, and target gene-TF regulatory network. Study of the ROC showed that ten genes (CCL5, IFNAR2, JAK2, MX1, STAT1, BID, CD55, CD80, HAL-B, and HLA-DMA) were substantially involved in SARS-CoV-2 patients. 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cell adhesion molecule 1"], ["TLR2", "0.589773", "0.013287", "0.013287", "2.617647", "Up", "toll like receptor 2"], ["KLRK1", "0.358136", "0.014239", "0.014239", "2.588898", "Up", "killer cell lectin like receptor K1"], ["MAP4K2", "0.221227", "0.018828", "0.018828", "2.471244", "Up", "Mitogen-activated protein kinase kinasekinasekinase 2"], ["KLRC1", "0.7945", "0.019896", "0.019896", "2.4477", "Up", "Killer cell lectin like receptor C1"], ["ATG5", "0.327", "0.020137", "0.020137", "2.44253", "Up", "Autophagy related 5"], ["IL18R1", "0.713136", "0.020905", "0.020905", "2.426467", "Up", "Interleukin 18 receptor 1"], ["IKBKB", "0.1695", "0.027641", "0.027641", "2.304841", "Up", "Inhibitor of nuclear factor kappa B kinase subunit beta"], ["STAT5B", "0.2575", "0.032278", "0.032278", "2.235871", "Up", "Signal transducer and activator of transcription 5B"], ["MX1", "1.111727", "0.032817", "0.032817", "2.228441", "Up", "MX dynamin like GTPase 1"], ["IRF7", "0.898909", "0.033248", "0.033248", "2.222589", "Up", "Interferon regulatory factor 7"], ["TRAF2", "0.171955", "0.034273", "0.034273", "2.208908", "Up", "TNF receptor associated factor 2"], ["IFI35", "0.725909", "0.035093", "0.035093", "2.198229", "Up", "Interferon induced protein 35"], ["IKBKE", "0.236545", "0.035149", "0.035149", "2.197514", "Up", "Inhibitor of nuclear factor kappa B kinase subunit epsilon"], ["CLEC7A", "0.421227", "0.037828", "0.037828", "2.164155", "Up", "C-type lectin domain containing 7A"], ["LTB4R", "0.465227", "0.03902", "0.03902", "2.149988", "Up", "Leukotriene B4 receptor"], ["GZMB", "0.437364", "0.040654", "0.040654", "2.131179", "Up", "Granzyme B"], ["NLRP3", "0.290364", "0.04286", "0.04286", "2.106829", "Up", "NLR family pyrin domain containing 3"], ["LILRB2", "0.299364", "0.042931", "0.042931", "2.106059", "Up", "Leukocyte immunoglobulin like receptor B2"], ["IFNAR2", "0.184136", "0.048633", "0.048633", "2.047965", "Up", "Interferon alpha and beta receptor subunit 2"], ["KLRD1", "0.4455", "0.049759", "0.049759", "2.037205", "Up", "Killer cell lectin like receptor D1"], ["CD19", "− 1.7175", "5.18E − 16", "5.18E − 16", "− 14.7177", "Down", "CD19 molecule"], ["CD22", "− 1.757", "4.93E − 15", "4.93E − 15", "− 13.592", "Down", "CD22 molecule"], ["MS4A1", "− 1.67741", "1.67E − 14", "1.67E − 14", "− 13.0082", "Down", "Membrane spanning 4-domains A1"], ["CD45RB", "− 0.94709", "4.17E − 14", "4.17E − 14", "− 12.5832", "Down", "Receptor-Type Tyrosine-Protein Phosphatase C"], ["IL6R", "− 2.0375", "1.05E − 13", "1.05E − 13", "− 12.164", "Down", "interleukin 6 receptor"], ["TNFRSF13C", "− 1.46186", "2.18E − 13", "2.18E − 13", "− 11.8375", "Down", "TNF receptor superfamily member 13C"], ["PAX5", "− 1.37636", "2.92E − 13", "2.92E − 13", "− 11.7085", "Down", "Paired box 5"], ["CD79A", "− 1.29577", "2.53E − 12", "2.53E − 12", "− 10.7841", "Down", "CD79a molecule"], ["ARHGDIB", "− 0.65064", "3.68E − 12", "3.68E − 12", "− 10.6278", "Down", "Rho GDP dissociation inhibitor beta"], ["HLA-DQB1", "− 4.88305", "5.18E − 12", "5.18E − 12", "− 10.4865", "Down", "Major histocompatibility complex, class II, DQ beta 1"], ["HLA-DQA1", "− 6.1155", "1.8E − 11", "1.8E − 11", "− 9.98021", "Down", "Major histocompatibility complex, class II, DQ alpha 1"], ["MAPKAPK2", "− 0.99755", "5.49E − 11", "5.49E − 11", "− 9.53915", "Down", "MAPK activated protein kinase 2"], ["SLAMF6", "− 0.87414", "2.16E − 10", "2.16E − 10", "− 9.01008", "Down", "SLAM family member 6"], ["PTGER4", "− 0.76932", "2.43E − 10", "2.43E − 10", "− 8.96519", "Down", "Prostaglandin E receptor 4"], ["CD79B", "− 0.84082", "2.75E − 10", "2.75E − 10", "− 8.91788", "Down", "CD79b molecule"], ["CD97", "− 1.1985", "3.22E − 10", "3.22E − 10", "− 8.85915", "Down", "Leukocyte antigen CD97"], ["IL1RL2", "− 1.04873", "3.57E − 10", "3.57E − 10", "− 8.81964", "Down", "Interleukin 1 receptor like 2"], ["CD1A", "− 1.07114", "3.6E − 10", "3.6E − 10", "− 8.81626", "Down", "CD1a molecule"], ["IL1RAP", "− 1.43418", "8.92E − 10", "8.92E − 10", "− 8.47672", "Down", "Interleukin 1 receptor accessory protein"], ["TNFSF12", "− 0.53718", "2.42E − 09", "2.42E − 09", "− 8.10915", "Down", "TNF superfamily member 12"], ["AICDA", "− 0.94759", "2.89E − 09", "2.89E − 09", "− 8.04473", "Down", "Activation induced cytidinedeaminase"], ["MBP", "− 0.77614", "4.02E − 09", "4.02E − 09", "− 7.92468", "Down", "myelin basic protein"], ["TRAF4", "− 0.67777", "5.69E − 09", "5.69E − 09", "− 7.79888", "Down", "TNF receptor associated factor 4"], ["MIF", "− 0.59309", "5.94E − 09", "5.94E − 09", "− 7.78344", "Down", "Macrophage migration inhibitory factor"], ["CCBP2", "− 1.34027", "6.31E − 09", "6.31E − 09", "− 7.76207", "Down", "Chemokine-binding protein 2"], ["CCL22", "− 0.68986", "8.3E − 09", "8.3E − 09", "− 7.66358", "Down", "C–C motif chemokine ligand 22"], ["HLA-DRA", "− 1.87223", "9.28E − 09", "9.28E − 09", "− 7.62328", "Down", "Major histocompatibility complex, class II, DR alpha"], ["FCER1A", "− 2.15768", "9.79E − 09", "9.79E − 09", "− 7.60411", "Down", "Fc fragment of IgE receptor Ia"], ["LILRB5", "− 0.76595", "1.11E − 08", "1.11E − 08", "− 7.55809", "Down", "Leukocyte immunoglobulin like receptor B5"], ["CCL15", "− 0.7105", "1.48E − 08", "1.48E − 08", "− 7.4567", "Down", "C–C motif chemokine ligand 15"], ["IL12B", "− 0.99886", "1.5E − 08", "1.5E − 08", "− 7.45174", "Down", "Interleukin 12B"], ["TFRC", "− 1.07782", "1.61E − 08", "1.61E − 08", "− 7.42698", "Down", "Transferrin receptor"], ["EBI3", "− 0.72195", "1.86E − 08", "1.86E − 08", "− 7.37653", "Down", "Epstein-Barr virus induced 3"], ["IL4", "− 0.69941", "2.72E − 08", "2.72E − 08", "− 7.24189", "Down", "Interleukin 4"], ["ICAM2", "− 0.74745", "2.86E − 08", "2.86E − 08", "− 7.22422", "Down", "Intercellular adhesion molecule 2"], ["KLRAP1", "− 1.0865", "3.09E − 08", "3.09E − 08", "− 7.19683", "Down", "Killer cell lectin-like receptor subfamily A pseudogene 1"], ["CD40", "− 0.79436", "3.29E − 08", "3.29E − 08", "− 7.17439", "Down", "CD40 molecule"], ["IL22RA2", "− 0.6365", "4.34E − 08", "4.34E − 08", "− 7.07766", "Down", "Interleukin 22 receptor subunit alpha 2"], ["IL2", "− 0.64395", "4.65E − 08", "4.65E − 08", "− 7.05298", "Down", "Interleukin 2"], ["IL29", "− 0.64395", "4.65E − 08", "4.65E − 08", "− 7.05298", "Down", "Interleukin 29"], ["CD3E", "− 0.73018", "5.24E − 08", "5.24E − 08", "− 7.01159", "Down", "CD3e molecule"], ["CD55", "− 0.92114", "5.29E − 08", "5.29E − 08", "− 7.00828", "Down", "CD55 molecule (Cromer blood group)"], ["IL19", "− 0.6555", "5.33E − 08", "5.33E − 08", "− 7.00515", "Down", "Interleukin 19"], ["NOS2", "− 0.81432", "5.6E − 08", "5.6E − 08", "− 6.98829", "Down", "Nitric oxide synthase 2"], ["C4BPA", "− 1.83359", "5.78E − 08", "5.78E − 08", "− 6.97697", "Down", "Complement component 4 binding protein alpha"], ["CCL26", "− 0.57677", "6.5E − 08", "6.5E − 08", "− 6.93596", "Down", "C–C motif chemokine ligand 26"], ["CDH5", "− 0.60586", "7.09E − 08", "7.09E − 08", "− 6.90577", "Down", "Cadherin 5"], ["IL9", "− 0.60586", "7.09E − 08", "7.09E − 08", "− 6.90577", "Down", "Interleukin 9"], ["FCGRT", "− 0.75709", "8.18E − 08", "8.18E − 08", "− 6.85603", "Down", "Fc fragment of IgG receptor and transporter"], ["C8B", "− 0.6555", "1.1E − 07", "1.1E − 07", "− 6.75159", "Down", "Complement C8 beta chain"], ["IL5", "− 0.64086", "1.16E − 07", "1.16E − 07", "− 6.7344", "Down", "Interleukin 5"], ["PIGR", "− 0.66695", "1.33E − 07", "1.33E − 07", "− 6.68821", "Down", "Polymeric immunoglobulin receptor"], ["XCL1", "− 1.06423", "1.98E − 07", "1.98E − 07", "− 6.54928", "Down", "X-C motif chemokine ligand 1"], ["AIRE", "− 0.78032", "2.01E − 07", "2.01E − 07", "− 6.5441", "Down", "Autoimmune regulator"], ["IL3", "− 0.60723", "2.08E − 07", "2.08E − 07", "− 6.53283", "Down", "Interleukin 3"], ["CCL16", "− 0.6195", "2.31E − 07", "2.31E − 07", "− 6.4973", "Down", "C–C motif chemokine ligand 16"], ["CCL7", "− 0.6195", "2.31E − 07", "2.31E − 07", "− 6.4973", "Down", "C–C motif chemokine ligand 7"], ["CSF2", "− 0.6195", "2.31E − 07", "2.31E − 07", "− 6.4973", "Down", "Colony stimulating factor 2"], ["ITLN2", "− 0.6195", "2.31E − 07", "2.31E − 07", "− 6.4973", "Down", "Intelectin 2"], ["THY1", "− 0.6195", "2.31E − 07", "2.31E − 07", "− 6.4973", "Down", "Thy-1 cell surface antigen"], ["IL21", "− 0.70245", "3.28E − 07", "3.28E − 07", "− 6.37574", "Down", "Interleukin 21"], ["BCL2", "− 0.7385", "4.11E − 07", "4.11E − 07", "− 6.29854", "Down", "BCL2 apoptosis regulator"], ["EDNRB", "− 0.60541", "4.11E − 07", "4.11E − 07", "− 6.29833", "Down", "Endothelin receptor type B"], ["CCR6", "− 0.88205", "4.78E − 07", "4.78E − 07", "− 6.24666", "Down", "C–C motif chemokine receptor 6"], ["TIRAP", "− 0.70182", "5.91E − 07", "5.91E − 07", "− 6.17398", "Down", "TIR domain containing adaptor protein"], ["STAT6", "− 0.52186", "6.37E − 07", "6.37E − 07", "− 6.14848", "Down", "Signal transducer and activator of transcription 6"], ["PSMB10", "− 0.43945", "6.43E − 07", "6.43E − 07", "− 6.14519", "Down", "Proteasome 20S subunit beta 10"], ["SKI", "− 0.52182", "7.16E − 07", "7.16E − 07", "− 6.10886", "Down", "SKI proto-oncogene"], ["RAG2", "− 0.56723", "8.47E − 07", "8.47E − 07", "− 6.05149", "Down", "Recombination activating 2"], ["CD209", "− 0.7285", "8.56E − 07", "8.56E − 07", "− 6.04758", "Down", "CD209 molecule"], ["VTN", "− 0.68305", "9.43E − 07", "9.43E − 07", "− 6.01488", "Down", "Vitronectin"], ["IFNB1", "− 0.57768", "9.97E − 07", "9.97E − 07", "− 5.99573", "Down", "Interferon beta 1"], ["EOMES", "− 0.77505", "1.47E − 06", "1.47E − 06", "− 5.8643", "Down", "Eomesodermin"], ["CD74", "− 0.69905", "1.52E − 06", "1.52E − 06", "− 5.85145", "Down", "CD74 molecule"], ["CCR10", "− 0.60368", "1.7E − 06", "1.7E − 06", "− 5.81503", "Down", "C–C motif chemokine receptor 10"], ["LGALS3", "− 1.12309", "1.85E − 06", "1.85E − 06", "− 5.78563", "Down", "Galectin 3"], ["PDGFB", "− 0.64241", "1.86E − 06", "1.86E − 06", "− 5.78395", "Down", "Platelet derived growth factor subunit B"], ["ICAM4", "− 0.96814", "1.96E − 06", "1.96E − 06", "− 5.76557", "Down", "Intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)"], ["ICOSLG", "− 0.74791", "2.07E − 06", "2.07E − 06", "− 5.74698", "Down", "Inducible T cell costimulator ligand"], ["C9", "− 0.52132", "2.66E − 06", "2.66E − 06", "− 5.66169", "Down", "Complement C9"], ["IL16", "− 0.45973", "2.88E − 06", "2.88E − 06", "− 5.63467", "Down", "Interleukin 16"], ["RELA", "− 0.47205", "3.09E − 06", "3.09E − 06", "− 5.61097", "Down", "RELA proto-oncogene, NF-kB subunit"], ["DEFB1", "− 0.8105", "3.38E − 06", "3.38E − 06", "− 5.58051", "Down", "Defensin beta 1"], ["IL13RA1", "− 0.90159", "3.41E − 06", "3.41E − 06", "− 5.57755", "Down", "Interleukin 13 receptor subunit alpha 1"], ["HLA-DOB", "− 1.24595", "3.65E − 06", "3.65E − 06", "− 5.55493", "Down", "Major histocompatibility complex, class II, DO beta"], ["KIR3DL3", "− 0.56905", "3.78E − 06", "3.78E − 06", "− 5.54244", "Down", "Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3"], ["HLA-C", "− 0.93941", "3.97E − 06", "3.97E − 06", "− 5.52568", "Down", "Major histocompatibility complex, class I, C"], ["KLRB1", "− 1.79632", "5.31E − 06", "5.31E − 06", "− 5.42732", "Down", "Killer cell lectin like receptor B1"], ["HLA-DMB", "− 0.85005", "5.86E − 06", "5.86E − 06", "− 5.39367", "Down", "Major histocompatibility complex, class II, DM beta"], ["KLRF2", "− 0.53859", "6E − 06", "6E − 06", "− 5.3857", "Down", "Killer cell lectin like receptor F2"], ["ICAM3", "− 0.66718", "6.38E − 06", "6.38E − 06", "− 5.36481", "Down", "Intercellular adhesion molecule 3"], ["IL28A", "− 0.55718", "7.03E − 06", "7.03E − 06", "− 5.33194", "Down", "Interleukin 28A"], ["SIGIRR", "− 0.41545", "7.52E − 06", "7.52E − 06", "− 5.30925", "Down", "Single Ig and TIR domain containing"], ["MASP2", "− 0.68927", "7.93E − 06", "7.93E − 06", "− 5.29109", "Down", "Mannan binding lectin serine peptidase 2"], ["CSF2RB", "− 1.12332", "8.36E − 06", "8.36E − 06", "− 5.27318", "Down", "Colony stimulating factor 2 receptor beta common subunit"], ["CD46", "− 0.59905", "9.11E − 06", "9.11E − 06", "− 5.24408", "Down", "CD46 molecule"], ["S1PR1", "− 0.60436", "9.23E − 06", "9.23E − 06", "− 5.23966", "Down", "Sphingosine − 1-phosphate receptor 1"], ["TLR9", "− 0.56841", "1.05E − 05", "1.05E − 05", "− 5.19438", "Down", "Toll like receptor 9"], ["HLA-DPB1", "− 0.70064", "1.07E − 05", "1.07E − 05", "− 5.19046", "Down", "Major histocompatibility complex, class II, DP beta 1"], ["CCL13", "− 0.57018", "1.16E − 05", "1.16E − 05", "− 5.16161", "Down", "C–C motif chemokine ligand 13"], ["PLA2G2E", "− 0.67155", "1.19E − 05", "1.19E − 05", "-5.15362", "Down", "Phospholipase A2 group IIE"], ["IL20", "− 0.67032", "1.29E − 05", "1.29E − 05", "-5.12687", "Down", "Interleukin 20"], ["PTAFR", "− 0.91373", "1.37E − 05", "1.37E − 05", "-5.10671", "Down", "Platelet activating factor receptor"], ["TGFBI", "− 0.59209", "1.44E − 05", "1.44E − 05", "-5.08943", "Down", "Transforming growth factor beta induced"], ["IL26", "− 0.50514", "1.52E − 05", "1.52E − 05", "-5.07029", "Down", "Interleukin 26"], ["IFNAR1", "− 0.78755", "2.03E − 05", "2.03E − 05", "− 4.97214", "Down", "Interferon alpha and beta receptor subunit 1"], ["LTA", "− 0.56282", "2.17E − 05", "2.17E − 05", "− 4.94915", "Down", "Lymphotoxin alpha"], ["FCGR2B", "− 0.85355", "2.4E − 05", "2.4E − 05", "− 4.91443", "Down", "Fc fragment of IgG receptor IIb"], ["EGR1", "− 0.63082", "2.41E − 05", "2.41E − 05", "− 4.9133", "Down", "Early growth response 1"], ["CD86", "− 0.76691", "2.54E − 05", "2.54E − 05", "− 4.89525", "Down", "CD86 molecule"], ["CD82", "− 0.99568", "2.76E − 05", "2.76E − 05", "− 4.86674", "Down", "CD82 molecule"], ["CD34", "− 0.56045", "2.79E − 05", "2.79E − 05", "− 4.86293", "Down", "CD34 molecule"], ["TRAF3", "− 0.46214", "2.87E − 05", "2.87E − 05", "− 4.85429", "Down", "TNF receptor associated factor 3"], ["CTLA4", "− 0.53577", "3E − 05", "3E − 05", "− 4.83886", "Down", "Cytotoxic T-Lymphocyte Associated Protein 4"], ["HAMP", "− 0.61205", "3E − 05", "3E − 05", "− 4.83856", "Down", "Hepcidin antimicrobial peptide"], ["EGR2", "− 0.78873", "3.15E − 05", "3.15E − 05", "− 4.82228", "Down", "Early growth response 2"], ["ICAM5", "− 0.53214", "3.22E − 05", "3.22E − 05", "− 4.81493", "Down", "Intercellular adhesion molecule 5"], ["CSF1R", "− 0.70273", "3.45E − 05", "3.45E − 05", "− 4.79056", "Down", "Colony stimulating factor 1 receptor"], ["NT5E", "− 0.85836", "3.68E − 05", "3.68E − 05", "− 4.76884", "Down", "5′-nucleotidase ecto"], ["IL7", "− 0.74464", "4.3E − 05", "4.3E − 05", "− 4.71548", "Down", "Interleukin 7"], ["CTSS", "− 0.62991", "4.34E − 05", "4.34E − 05", "− 4.71277", "Down", "Cathepsin S"], ["IL17B", "− 0.55268", "4.82E − 05", "4.82E − 05", "− 4.6769", "Down", "Interleukin 17B"], ["CR2", "− 1.00786", "4.86E − 05", "4.86E − 05", "− 4.67369", "Down", "Complement C3d receptor 2"], ["CD44", "− 0.35164", "5.25E − 05", "5.25E − 05", "− 4.64701", "Down", "CD44 molecule (Indian blood group)"], ["PLA2G2A", "− 0.53655", "5.77E − 05", "5.77E − 05", "− 4.61492", "Down", "Phospholipase A2 group IIA"], ["BTK", "− 0.45495", "5.87E − 05", "5.87E − 05", "− 4.60896", "Down", "Bruton tyrosine kinase"], ["C6", "− 0.65964", "5.95E − 05", "5.95E − 05", "− 4.60439", "Down", "Complement C6"], ["IRGM", "− 0.62291", "6.21E − 05", "6.21E − 05", "− 4.58953", "Down", "Immunity related GTPase M"], ["IL22", "− 0.65314", "7.15E − 05", "7.15E − 05", "− 4.54121", "Down", "Interleukin 22"], ["CEBPB", "− 0.88709", "7.69E − 05", "7.69E − 05", "− 4.51625", "Down", "CCAAT enhancer binding protein beta"], ["IL6", "− 0.69105", "7.91E − 05", "7.91E − 05", "− 4.50639", "Down", "Interleukin 6"], ["IFNA2", "− 0.77586", "8.23E − 05", "8.23E − 05", "− 4.49296", "Down", "Interferon alpha 2"], ["TGFBR1", "− 0.40336", "8.66E − 05", "8.66E − 05", "− 4.47511", "Down", "Transforming growth factor beta receptor 1"], ["IL17F", "− 0.54009", "8.83E − 05", "8.83E − 05", "− 4.4686", "Down", "Interleukin 17F"], ["IL28A/B", "− 0.55282", "0.000163", "0.000163", "− 4.25674", "Down", "Interleukin 28A/B"], ["IL17A", "− 0.53723", "0.00018", "0.00018", "− 4.22236", "Down", "Interleukin 17A"], ["LILRA2", "− 0.68495", "0.000195", "0.000195", "− 4.194", "Down", "Leukocyte immunoglobulin like receptor A2"], ["LILRA3", "− 2.33691", "0.000203", "0.000203", "− 4.18055", "Down", "Leukocyte immunoglobulin like receptor A3"], ["VCAM1", "− 0.60605", "0.000219", "0.000219", "− 4.15259", "Down", "Vascular cell adhesion molecule 1"], ["SPP1", "− 0.6555", "0.000221", "0.000221", "− 4.1496", "Down", "Secreted phosphoprotein 1"], ["CARD9", "− 0.55227", "0.000269", "0.000269", "− 4.0818", "Down", "Caspase recruitment domain family member 9"], ["LCK", "− 0.40364", "0.000299", "0.000299", "− 4.04398", "Down", "LCK proto-oncogene, Src family tyrosine kinase"], ["SELE", "− 0.52332", "0.000306", "0.000306", "− 4.03551", "Down", "selectin E"], ["SLC2A1", "− 0.44118", "0.00036", "0.00036", "− 3.97865", "Down", "solute carrier family 2 member 1"], ["LIF", "− 0.50555", "0.000368", "0.000368", "− 3.97037", "Down", "LIF interleukin 6 family cytokine"], ["IDO1", "− 0.95541", "0.000417", "0.000417", "− 3.92685", "Down", "Indoleamine 2,3-dioxygenase 1"], ["TNFRSF10C", "− 0.88564", "0.000471", "0.000471", "− 3.88294", "Down", "TNF receptor superfamily member 10c"], ["IL23A", "− 0.87541", "0.000557", "0.000557", "− 3.82374", "Down", "interleukin 23 subunit alpha"], ["CD80", "− 0.58964", "0.000567", "0.000567", "− 3.81702", "Down", "CD80 molecule"], ["GPR183", "− 1.088", "0.00057", "0.00057", "− 3.81527", "Down", "G protein-coupled receptor 183"], ["C1R", "− 0.41727", "0.000592", "0.000592", "− 3.8018", "Down", "Complement C1r"], ["CCL11", "− 0.55055", "0.000611", "0.000611", "− 3.79064", "Down", "C–C motif chemokine ligand 11"], ["HLA-DPA1", "− 0.6385", "0.000637", "0.000637", "− 3.77577", "Down", "major histocompatibility complex, class II, DP alpha 1"], ["IFNG", "− 0.877", "0.00073", "0.00073", "− 3.72658", "Down", "Interferon gamma"], ["DUSP4", "− 0.70741", "0.000789", "0.000789", "− 3.69861", "Down", "Dual specificity phosphatase 4"], ["IL27", "− 0.44905", "0.000852", "0.000852", "− 3.67089", "Down", "Interleukin 27"], ["CD48", "− 1.15805", "0.000953", "0.000953", "− 3.6304", "Down", "CD48 molecule"], ["FN1", "− 0.56177", "0.001005", "0.001005", "− 3.61111", "Down", "fibronectin 1"], ["CD244", "− 0.39427", "0.001018", "0.001018", "− 3.60646", "Down", "CD244 molecule"], ["PPBP", "− 1.35464", "0.001091", "0.001091", "− 3.58105", "Down", "pro-platelet basic protein"], ["IL13", "− 0.599", "0.001204", "0.001204", "− 3.54515", "Down", "interleukin 13"], ["CCL24", "− 0.45395", "0.001221", "0.001221", "− 3.53987", "Down", "C–C motif chemokine ligand 24"], ["GATA3", "− 0.55041", "0.001228", "0.001228", "− 3.53797", "Down", "GATA binding protein 3"], ["BID", "− 0.46636", "0.001281", "0.001281", "− 3.52243", "Down", "BH3 interacting domain death agonist"], ["BCL2L11", "− 0.40091", "0.001565", "0.001565", "− 3.44881", "Down", "BCL2 like 11"], ["KIT", "− 0.52868", "0.001589", "0.001589", "− 3.44316", "Down", "KIT proto-oncogene, receptor tyrosine kinase"], ["MME", "− 1.00591", "0.001596", "0.001596", "− 3.44151", "Down", "Membrane metalloendopeptidase"], ["ZEB1", "− 0.38082", "0.001667", "0.001667", "− 3.42548", "Down", "Zinc finger E-box binding homeobox 1"], ["C4A/B", "− 0.62314", "0.001738", "0.001738", "− 3.40994", "Down", "Complement C4A/B"], ["FCAR", "− 0.50423", "0.00198", "0.00198", "− 3.36169", "Down", "Fc fragment of IgA receptor"], ["BTLA", "− 0.45623", "0.002033", "0.002033", "− 3.35183", "Down", "B and T lymphocyte associated"], ["TAGAP", "− 0.38886", "0.002261", "0.002261", "− 3.31206", "Down", "T cell activation RhoGTPase activating protein"], ["CD83", "− 0.39914", "0.002292", "0.002292", "− 3.307", "Down", "CD83 molecule"], ["SELPLG", "− 0.37564", "0.002362", "0.002362", "-3.29575", "Down", "Selectin P ligand"], ["B3GAT1", "− 0.66791", "0.002423", "0.002423", "− 3.28614", "Down", "Beta-1,3-glucuronyltransferase 1"], ["CCRL1", "− 0.39195", "0.002543", "0.002543", "− 3.26788", "Down", "C–C chemokine receptor type 11"], ["TNFRSF14", "− 0.29986", "0.002557", "0.002557", "− 3.26588", "Down", "TNF receptor superfamily member 14"], ["CSF3R", "− 0.65318", "0.003003", "0.003003", "− 3.20507", "Down", "Colony stimulating factor 3 receptor"], ["CD9", "− 0.87091", "0.003004", "0.003004", "− 3.20497", "Down", "CD9 molecule"], ["C1S", "− 0.52059", "0.003211", "0.003211", "− 3.17969", "Down", "complement C1s"], ["PECAM1", "− 0.30873", "0.003251", "0.003251", "− 3.17496", "Down", "platelet and endothelial cell adhesion molecule 1"], ["DEFB103B", "− 0.4315", "0.003466", "0.003466", "− 3.15055", "Down", "Defensin beta 103B"], ["ITLN1", "− 1.17682", "0.003488", "0.003488", "− 3.14815", "Down", "Intelectin 1"], ["CXCL13", "− 0.46586", "0.003554", "0.003554", "− 3.14101", "Down", "C-X-C motif chemokine ligand 13"], ["RAG1", "− 0.47836", "0.003917", "0.003917", "− 3.10376", "Down", "Recombination activating 1"], ["TNFRSF4", "− 0.55123", "0.004154", "0.004154", "− 3.08112", "Down", "TNF receptor superfamily member 4"], ["C14orf166", "− 0.35727", "0.004255", "0.004255", "− 3.07189", "Down", "Chromosome 14 open reading frame 166"], ["IL10RA", "− 0.26059", "0.004423", "0.004423", "− 3.0569", "Down", "Interleukin 10 receptor subunit alpha"], ["POU2F2", "− 0.292", "0.004614", "0.004614", "− 3.04059", "Down", "POU class 2 homeobox 2"], ["C7", "− 0.41223", "0.004688", "0.004688", "− 3.03441", "Down", "complement C7"], ["RORC", "− 0.52768", "0.005006", "0.005006", "− 3.00891", "Down", "RAR related orphan receptor C"], ["CXCL11", "− 0.83891", "0.005151", "0.005151", "− 2.99784", "Down", "C-X-C motif chemokine ligand 11"], ["MASP1", "− 0.50677", "0.005182", "0.005182", "− 2.99543", "Down", "Mannan binding lectin serine peptidase 1"], ["MAP4K4", "− 0.37777", "0.005449", "0.005449", "− 2.97583", "Down", "Mitogen-activated protein kinase kinasekinasekinase 4"], ["CX3CL1", "− 0.50445", "0.005597", "0.005597", "− 2.96535", "Down", "C-X3-C motif chemokine ligand 1"], ["BATF3", "− 0.62586", "0.005862", "0.005862", "− 2.94725", "Down", "Basic leucine zipper ATF-like transcription factor 3"], ["CCR8", "− 0.51627", "0.005946", "0.005946", "− 2.94164", "Down", "C–C motif chemokine receptor 8"], ["TAL1", "− 1.01455", "0.006016", "0.006016", "− 2.93707", "Down", "TAL bHLH transcription factor 1, erythroid differentiation factor"], ["NFIL3", "− 0.723", "0.007", "0.007", "− 2.87725", "Down", "Nuclear factor, interleukin 3 regulated"], ["CD8A", "− 0.50595", "0.007337", "0.007337", "− 2.85858", "Down", "CD8a molecule"], ["CLEC6A", "− 0.62323", "0.007445", "0.007445", "− 2.85274", "Down", "C-type lectin domain containing 6A"], ["TCF4", "− 0.37827", "0.007904", "0.007904", "− 2.8289", "Down", "Transcription factor 4"], ["FCGR2A", "− 0.664", "0.009089", "0.009089", "− 2.77283", "Down", "Fc fragment of IgG receptor IIa"], ["HLA-B", "− 0.31677", "0.00918", "0.00918", "− 2.76877", "Down", "major histocompatibility complex, class I, B"], ["IRF8", "− 0.39477", "0.009346", "0.009346", "− 2.76157", "Down", "Interferon regulatory factor 8"], ["MAPK11", "− 0.60427", "0.010152", "0.010152", "− 2.72804", "Down", "Mitogen-activated protein kinase 11"], ["ILF3", "− 0.17055", "0.010366", "0.010366", "− 2.71958", "Down", "Interleukin enhancer binding factor 3"], ["XCR1", "− 0.34541", "0.01065", "0.01065", "− 2.70856", "Down", "X–C motif chemokine receptor 1"], ["ITGAE", "− 0.33509", "0.011424", "0.011424", "− 2.67988", "Down", "Integrin subunit alpha E"], ["IL4R", "− 0.69064", "0.012538", "0.012538", "− 2.64162", "Down", "Interleukin 4 receptor"], ["CTSC", "− 0.16718", "0.012619", "0.012619", "− 2.63897", "Down", "Cathepsin C"], ["ETS1", "− 0.39405", "0.013255", "0.013255", "− 2.61865", "Down", "ETS proto-oncogene 1, transcription factor"], ["CFI", "− 0.30082", "0.013335", "0.013335", "− 2.61614", "Down", "Complement factor I"], ["STAT5A", "− 0.27168", "0.014802", "0.014802", "− 2.57273", "Down", "Signal transducer and activator of transcription 5A"], ["C8A", "− 0.37964", "0.016204", "0.016204", "− 2.53478", "Down", "Complement C8 alpha chain"], ["DEFB4A", "− 0.36691", "0.017835", "0.017835", "− 2.49428", "Down", "Defensin beta 4A"], ["RELB", "− 0.45095", "0.019351", "0.019351", "− 2.45958", "Down", "RELB proto-oncogene, NF-kB subunit"], ["ATG7", "− 0.32859", "0.01984", "0.01984", "− 2.4489", "Down", "Autophagy related 7"], ["DPP4", "− 0.38823", "0.01999", "0.01999", "− 2.44568", "Down", "Dipeptidyl peptidase 4"], ["GPI", "− 0.21382", "0.020424", "0.020424", "− 2.43646", "Down", "Glucose-6-phosphate isomerase"], ["CD59", "− 0.24032", "0.020561", "0.020561", "− 2.43359", "Down", "CD59 molecule (CD59 blood group)"], ["CASP3", "− 0.40573", "0.025629", "0.025629", "− 2.33807", "Down", "Caspase 3"], ["TIGIT", "− 0.3615", "0.025963", "0.025963", "− 2.33239", "Down", "T cell immunoreceptor with Ig and ITIM domains"], ["CFD", "− 0.36627", "0.026073", "0.026073", "− 2.33053", "Down", "Complement factor D"], ["CCL18", "− 0.42077", "0.026944", "0.026944", "− 2.3161", "Down", "C–C motif chemokine ligand 18"], ["PLAU", "− 0.34086", "0.028132", "0.028132", "− 2.29706", "Down", "Plasminogen activator, urokinase"], ["PTPN22", "− 0.20086", "0.028829", "0.028829", "− 2.28623", "Down", "Protein tyrosine phosphatase non-receptor type 22"], ["TOLLIP", "− 0.27377", "0.028911", "0.028911", "− 2.28497", "Down", "Toll interacting protein"], ["CXCR2", "− 0.49195", "0.029438", "0.029438", "− 2.27696", "Down", "C-X-C motif chemokine receptor 2"], ["CCL20", "− 0.34555", "0.029871", "0.029871", "− 2.27048", "Down", "C–C motif chemokine ligand 20"], ["IL12A", "− 0.40759", "0.03046", "0.03046", "− 2.26179", "Down", "Interleukin 12A"], ["IL10", "− 0.33555", "0.03205", "0.03205", "− 2.23904", "Down", "Interleukin 10"], ["LILRA1", "− 0.26991", "0.033542", "0.033542", "− 2.21862", "Down", "leukocyte immunoglobulin like receptor A1"], ["PTPN6", "− 0.16109", "0.034722", "0.034722", "− 2.20304", "Down", "protein tyrosine phosphatase non-receptor type 6"], ["CCL19", "− 0.37718", "0.035605", "0.035605", "− 2.19168", "Down", "C–C motif chemokine ligand 19"], ["IKBKAP", "− 0.15505", "0.035624", "0.035624", "− 2.19144", "Down", "IκB kinase complex-associated protein"], ["TNFRSF9", "− 0.50786", "0.036235", "0.036235", "− 2.18372", "Down", "TNF receptor superfamily member 9"], ["TCF7", "− 0.60091", "0.036564", "0.036564", "− 2.17963", "Down", "Transcription factor 7"], ["HLA-DMA", "− 0.30777", "0.036925", "0.036925", "− 2.17516", "Down", "Major histocompatibility complex, class II, DM alpha"], ["CXCL12", "− 0.69291", "0.037168", "0.037168", "− 2.17218", "Down", "C-X-C motif chemokine ligand 12"], ["MBL2", "− 0.37009", "0.037623", "0.037623", "− 2.16664", "Down", "Mannose binding lectin 2"], ["IKZF2", "− 0.46655", "0.039489", "0.039489", "− 2.14452", "Down", "IKAROS family zinc finger 2"], ["BCAP31", "− 0.10632", "0.04075", "0.04075", "− 2.13009", "Down", "B cell receptor associated protein 31"], ["HLA-DRB1", "− 1.39495", "0.041403", "0.041403", "− 2.12278", "Down", "Major histocompatibility complex, class II, DR beta 1"], ["IRAK4", "− 0.23727", "0.041428", "0.041428", "− 2.12251", "Down", "Interleukin 1 receptor associated kinase 4"], ["CXCR1", "− 0.49741", "0.041833", "0.041833", "− 2.11802", "Down", "C-X-C motif chemokine receptor 1"], ["PTK2", "− 0.33609", "0.043242", "0.043242", "− 2.10272", "Down", "Protein tyrosine kinase 2"], ["CD45R0", "− 0.46514", "0.043373", "0.043373", "− 2.10132", "Down", "A member of leucocyte common antigen family"]], "row_count": 325, "column_count": 7, "numeric_cells": 1605, "header_rows": 1, "locator": "section[12]/table-wrap[1]#Tab1"}}, {"id": "asset:table:pmid:33251083:2", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:b7239eaa56eb9da9deefd70f1c000d77539072c6a251173f715314d5547a318e", "bytes": 10374, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[13]/table-wrap[1]#Tab2", "version": null, "note": "The enriched pathway terms of the up regulated differentially expressed genes", "structure": {"pmcid": "PMC7679428", "section_index": 5, "section_title": "Pathway enrichment analysis for DEGs", "row_count": 73, "column_count": 8}, "table": {"label": "Table 2", "caption": "The enriched pathway terms of the up regulated differentially expressed genes", "rows": [["KEGG"], ["Pathway ID", "Pathway Name", "P-value", "FDR B&H", "FDR B&Y", "Bonferroni", "Gene Count", "Gene"], ["213306", "Measles", "3.21E − 17", "4.46E − 15", "2.46E − 14", "4.46E − 15", "16", "CCND3, JAK1, JAK2, IFIH1, TRAF6, IKBKE, TLR2, IRF7, FYN, IL2RG, STAT1, TP53, STAT3, MX1, STAT5B, IFNAR2"], ["377873", "Herpes simplex infection", "1.19E − 13", "8.24E − 12", "4.54E − 11", "1.65E − 11", "15", "JAK1, JAK2, IFIH1, TRAF2, TRAF6, HLA-A, IKBKE, TLR2, C1QBP, CCL5, IRF7, IKBKB, STAT1, TP53, IFNAR2"], ["83079", "Natural killer cell mediated cytotoxicity", "5.40E − 13", "2.50E − 11", "1.38E − 10", "7.51E − 11", "13", "KLRK1, CD247, HLA-A, GZMB, HRAS, LCP2, ITGAL, FYN, ITGB2, KLRC1, ZAP70, KLRD1, IFNAR2"], ["193147", "Osteoclast differentiation", "1.85E − 10", "3.32E − 09", "1.83E − 08", "2.57E − 08", "11", "JAK1, TRAF2, TRAF6, LILRB2, LILRA6, SOCS1, IKBKB, LCP2, FYN, STAT1, IFNAR2"], ["83077", "Jak-STAT signaling pathway", "1.31E − 09", "1.83E − 08", "1.01E − 07", "1.83E − 07", "11", "CCND3, JAK1, JAK2, HRAS, SOCS1, IL2RG, STAT1, STAT3, STAT4, STAT5B, IFNAR2"], ["217173", "Influenza A", "3.94E − 09", "4.56E − 08", "2.51E − 07", "5.47E − 07", "11", "JAK1, JAK2, IFIH1, IKBKE, CCL5, IRF7, IKBKB, STAT1, NLRP3, MX1, IFNAR2"], ["373901", "HTLV-I infection", "2.27E − 08", "2.11E − 07", "1.16E − 06", "3.16E − 06", "12", "CCND3, JAK1, HLA-A, HRAS, XBP1, CTNNB1, IKBKB, ITGAL, ITGB2, IL2RG, TP53, STAT5B"], ["658418", "Viral carcinogenesis", "2.16E − 07", "1.67E − 06", "9.20E − 06", "3.00E − 05", "10", "CCND3, JAK1, TRAF2, HLA-A, HRAS, IRF7, CCR5, TP53, STAT3, STAT5B"], ["83080", "T cell receptor signaling pathway", "2.05E − 06", "1.36E − 05", "7.47E − 05", "2.85E − 04", "7", "PDCD1, CD247, HRAS, IKBKB, LCP2, FYN, ZAP70"], ["125138", "Viral myocarditis", "2.21E − 05", "1.18E − 04", "6.51E − 04", "3.07E − 03", "5", "ABL1, HLA-A, ITGAL, FYN, ITGB2"], ["213780", "Tuberculosis", "7.57E − 05", "3.63E − 04", "2.00E − 03", "1.05E − 02", "7", "JAK1, JAK2, TRAF6, TLR2, CLEC7A, ITGB2, STAT1"], ["83051", "Cytokine-cytokine receptor interaction", "1.59E − 04", "6.69E − 04", "3.69E − 03", "2.21E − 02", "8", "CCR1, CCL5, CCR5, IL18RAP, IL2RG, IL18R1, CX3CR1, IFNAR2"], ["152665", "Malaria", "1.79E − 04", "7.32E − 04", "4.04E − 03", "2.49E − 02", "4", "KLRK1, TLR2, ITGAL, ITGB2"], ["Pathway interaction database"], ["137922", "IL12-mediated signaling events", "1.37E − 17", "1.56E − 15", "8.29E − 15", "1.56E − 15", "13", "JAK2, CD247, HLA-A, TBX21, GZMB, SOCS1, CCR5, IL18RAP, IL2RG, IL18R1, STAT1, STAT3, STAT4"], ["137976", "IL2-mediated signaling events", "5.15E − 10", "2.94E − 08", "1.56E − 07", "5.88E − 08", "8", "JAK1, IKZF3, SOCS1, FYN, IL2RG, STAT1, STAT3, STAT5B"], ["138055", "TCR signaling in naive CD8 + T cells", "9.79E − 09", "2.35E − 07", "1.25E − 06", "1.12E − 06", "7", "TRAF6, CD247, HLA-A, IKBKB, LCP2, FYN, ZAP70"], ["138071", "PDGFR-beta signaling pathway", "6.28E − 07", "7.16E − 06", "3.81E − 05", "7.16E − 05", "6", "ABL1, HRAS, FYN, STAT1, STAT3, STAT5B"], ["137988", "IL2 signaling events mediated by STAT5", "2.52E − 05", "2.21E − 04", "1.17E − 03", "2.87E − 03", "4", "CCND3, JAK1, IL2RG, STAT5B"], ["138019", "p75(NTR)-mediated signaling", "5.25E − 03", "2.32E − 02", "1.23E − 01", "5.99E − 01", "3", "TRAF6, IKBKB, TP53"], ["138021", "Paxillin-dependent events mediated by a4b1", "5.29E − 03", "2.32E − 02", "1.23E − 01", "6.03E − 01", "2", "ITGAL, ITGB2"], ["137940", "Signaling events mediated by VEGFR1 and VEGFR2", "5.75E − 03", "2.43E − 02", "1.29E − 01", "6.55E − 01", "3", "HRAS, CTNNB1, FYN"], ["137983", "ALK2 signaling events", "6.18E − 02", "1.22E − 01", "6.47E − 01", "1.00E + 00", "1", "SMAD5"], ["138046", "Syndecan-1-mediated signaling events", "9.40E − 02", "1.70E − 01", "9.04E − 01", "1.00E + 00", "1", "CCL5"], ["REACTOME"], ["1269310", "Cytokine Signaling in Immune system", "3.94E − 16", "2.05E − 13", "1.40E − 12", "2.05E − 13", "28", "JAK1, JAK2, TRAF2, TRAF6, HLA-A, BST2, HRAS, PSMB9, GBP1, SOCS1, CCR1, IRF5, CCL5, IRF7, CCR5, IKBKB, FYN, IFI35, IL18RAP, ITGB2, IL2RG, IL18R1, STAT1, TP53, STAT3, MX1, STAT5B, IFNAR2"], ["1269203", "Innate Immune System", "1.61E − 13", "4.19E − 11", "2.86E − 10", "8.38E − 11", "32", "KLRK1, ATG5, JAK1, JAK2, IFIH1, TRAF2, TRAF6, CD247, ABL1, HLA-A, IKBKE, BST2, LILRB2, TLR2, HRAS, PSMB9, CLEC7A, SOCS1, C2, IRF7, GNLY, CTNNB1, IKBKB, LCP2, ITGAL, FYN, ITGB2, IL2RG, KLRD1, TP53, NLRP3, CEACAM1"], ["1269318", "Signaling by Interleukins", "9.69E − 11", "1.06E − 08", "7.24E − 08", "5.04E − 08", "19", "JAK1, JAK2, TRAF6, HRAS, PSMB9, SOCS1, CCR1, CCL5, CCR5, IKBKB, FYN, IL18RAP, ITGB2, IL2RG, IL18R1, STAT1, TP53, STAT3, STAT5B"], ["1269171", "Adaptive Immune System", "1.02E − 10", "1.06E − 08", "7.24E − 08", "5.30E − 08", "23", "KLRK1, PDCD1, TRAF6, CD247, ZBTB16, HLA-A, LILRB2, TLR2, LAG3, HRAS, LILRA6, PSMB9, SOCS1, SLAMF7, IKBKB, LCP2, ITGAL, FYN, ITGB2, KLRC1, ZAP70, KLRD1, TP53"], ["1269340", "Hemostasis", "5.49E − 07", "2.20E − 05", "1.50E − 04", "2.86E − 04", "16", "JAK1, JAK2, ABL1, CD99, HRAS, C1QBP, SERPING1, IRF7, LCP2, ITGAL, FYN, ITGB2, IL2RG, TP53, CEACAM1, GP1BB"], ["1269260", "TRAF3-dependent IRF activation pathway", "9.84E − 05", "1.55E − 03", "1.06E − 02", "5.12E − 02", "3", "IFIH1, IKBKE, IRF7"], ["1268854", "Disease", "1.26E − 03", "1.24E − 02", "8.44E − 02", "6.55E − 01", "13", "JAK2, CD247, HLA-A, TLR2, HRAS, PSMB9, CCR5, CTNNB1, IKBKB, FYN, STAT1, STAT3, STAT5B"], ["1268855", "Diseases of signal transduction", "1.35E − 03", "1.30E − 02", "8.90E − 02", "7.03E − 01", "8", "JAK2, HRAS, PSMB9, CTNNB1, FYN, STAT1, STAT3, STAT5B"], ["1269562", "Leukotriene receptors", "2.86E − 02", "8.96E − 02", "6.12E − 01", "1.00E + 00", "1", "LTB4R"], ["1269248", "Activation of C3 and C5", "3.98E − 02", "1.18E − 01", "8.08E − 01", "1.00E + 00", "1", "C2"], ["MSigDB C2 BIOCARTA (v6.0)"], ["M8066", "IL22 Soluble Receptor Signaling Pathway", "2.31E − 10", "3.56E − 08", "2.00E − 07", "3.56E − 08", "6", "JAK1, JAK2, STAT1, STAT3, STAT4, STAT5B"], ["M13494", "Bioactive Peptide Induced Signaling Pathway", "4.38E − 09", "3.38E − 07", "1.90E − 06", "6.75E − 07", "7", "JAK2, HRAS, FYN, STAT1, STAT3, STAT4, STAT5B"], ["M1462", "CTL mediated immune response against target cells", "1.61E − 08", "7.50E − 07", "4.21E − 06", "2.48E − 06", "5", "CD247, HLA-A, GZMB, ITGAL, ITGB2"], ["M6231", "NO2-dependent IL 12 Pathway in NK cells", "2.31E − 06", "3.24E − 05", "1.82E − 04", "3.56E − 04", "4", "JAK2, CD247, CCR5, STAT4"], ["M13863", "MAPKinaseSignaling Pathway", "1.06E − 05", "1.08E − 04", "6.09E − 04", "1.63E − 03", "6", "TRAF2, MAP4K1, HRAS, IKBKB, MAP4K2, STAT1"], ["M6427", "T Helper Cell Surface Molecules", "6.45E − 05", "4.73E − 04", "2.66E − 03", "9.93E − 03", "3", "CD247, ITGAL, ITGB2"], ["M4047", "Selective expression of chemokine receptors during T-cell polarization", "6.08E − 04", "3.12E − 03", "1.75E − 02", "9.37E − 02", "3", "CCR1, CCR5, IL18R1"], ["M11358", "Tumor Suppressor Arf Inhibits Ribosomal Biogenesis", "4.24E − 03", "1.28E − 02", "7.19E − 02", "6.53E − 01", "2", "ABL1, TP53"], ["M17400", "ALK in cardiac myocytes", "1.93E − 02", "4.37E − 02", "2.45E − 01", "1.00E + 00", "2", "CTNNB1, SMAD5"], ["M5885", "Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors", "8.19E − 01", "8.30E − 01", "1.00E + 00", "1.00E + 00", "3", "CLEC7A, SERPING1, CCL5"], ["Panther DB"], ["P00038", "JAK/STAT signaling pathway", "1.76E − 12", "5.64E − 11", "2.29E − 10", "5.64E − 11", "7", "JAK1, JAK2, SOCS1, STAT1, STAT3, STAT4, STAT5B"], ["P00031", "Inflammation mediated by chemokine and cytokine signaling pathway", "1.44E − 06", "2.31E − 05", "9.37E − 05", "4.62E − 05", "9", "JAK2, CCRL2, CCR1, CCL5, CCR5, IKBKB, ITGAL, CX3CR1, STAT3"], ["P00054", "Toll receptor signaling pathway", "1.94E − 04", "1.03E − 03", "4.19E − 03", "6.20E − 03", "4", "TRAF6, IKBKE, TLR2, IKBKB"], ["P00006", "Apoptosis signaling pathway", "3.03E − 04", "1.39E − 03", "5.62E − 03", "9.69E − 03", "5", "TRAF2, GZMB, IKBKB, MAP4K2, TP53"], ["P00010", "B cell activation", "4.43E − 02", "9.45E − 02", "3.83E − 01", "1.00E + 00", "2", "HRAS, IKBKB"], ["P00052", "TGF-beta signaling pathway", "9.73E − 02", "1.67E − 01", "6.78E − 01", "1.00E + 00", "2", "HRAS, SMAD5"], ["P00011", "Blood coagulation", "2.07E − 01", "2.89E − 01", "1.00E + 00", "1.00E + 00", "1", "GP1BB"], ["P00012", "Cadherin signaling pathway", "2.34E − 01", "3.00E − 01", "1.00E + 00", "1.00E + 00", "2", "CTNNB1, FYN"], ["P00057", "Wntsignaling pathway", "2.59E − 01", "3.07E − 01", "1.00E + 00", "1.00E + 00", "3", "CTNNB1, TP53, SMAD5"], ["P00056", "VEGF signaling pathway", "2.86E − 01", "3.27E − 01", "1.00E + 00", "1.00E + 00", "1", "HRAS"], ["Pathway Ontology"], ["PW:0000125", "G protein signaling", "5.82E − 03", "3.10E − 02", "1.26E − 01", "1.86E − 01", "1", "LTB4R"], ["PW:0000297", "platelet-derived growth factor signaling", "5.82E − 03", "3.10E − 02", "1.26E − 01", "1.86E − 01", "1", "JAK2"], ["PW:0000143", "insulin signaling", "1.05E − 02", "3.36E − 02", "1.36E − 01", "3.37E − 01", "2", "SOCS1, STAT5B"], ["PW:0000330", "Bone morphogenetic proteins signaling", "2.86E − 02", "6.53E − 02", "2.65E − 01", "9.15E − 01", "1", "SMAD5"], ["PW:0000599", "altered canonical Wntsignaling", "2.86E − 02", "6.53E − 02", "2.65E − 01", "9.15E − 01", "1", "CTNNB1"], ["PW:0000508", "platelet aggregation", "3.42E − 02", "6.84E − 02", "2.78E − 01", "1.00E + 00", "1", "GP1BB"], ["PW:0000234", "innate immune response", "6.18E − 02", "1.10E − 01", "4.46E − 01", "1.00E + 00", "1", "TLR2"], ["PW:0000278", "autophagy", "1.04E − 01", "1.39E − 01", "5.65E − 01", "1.00E + 00", "1", "ATG10"], ["PW:0000243", "vascular endothelial growth factor signaling", "1.30E − 01", "1.49E − 01", "6.03E − 01", "1.00E + 00", "1", "FYN"], ["PW:0000490", "transforming growth factor-beta Smad dependent signaling", "1.40E − 01", "1.55E − 01", "6.28E − 01", "1.00E + 00", "1", "RUNX1"], ["SMPDB"], ["SMP00320", "Intracellular Signalling Through Adenosine Receptor A2a and Adenosine", "1.55E − 02", "2.46E − 02", "4.52E − 02", "4.65E − 02", "2", "HRAS, IKBKB"], ["SMP00391", "Insulin Signalling", "1.89E − 01", "1.89E − 01", "3.46E − 01", "5.66E − 01", "1", "HRAS"]], "row_count": 73, "column_count": 8, "numeric_cells": 420, "header_rows": 2, "locator": "section[13]/table-wrap[1]#Tab2"}}, {"id": "asset:table:pmid:33251083:3", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:307d19ecb0dfe452f834715a6c814a8c922a41eba5ff771952acf5734e1660b5", "bytes": 17321, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[13]/table-wrap[2]#Tab3", "version": null, "note": "The enriched pathway terms of the down regulated differentially expressed genes", "structure": {"pmcid": "PMC7679428", "section_index": 5, "section_title": "Pathway enrichment analysis for DEGs", "row_count": 91, "column_count": 8}, "table": {"label": "Table 3", "caption": "The enriched pathway terms of the down regulated differentially expressed genes", "rows": [["BIOCYC", "", "", "", "", "", "", ""], ["Pathway ID", "Pathway Name", "P-value", "FDR B&H", "FDR B&Y", "Bonferroni", "Gene Count", "Gene"], ["703092", "Citrulline-nitric oxide cycle", "8.83E − 02", "2.53E − 01", "8.24E − 01", "1.00E + 00", "1", "NOS2"], ["142419", "Phospholipases", "9.82E − 02", "2.53E − 01", "8.24E − 01", "1.00E + 00", "1", "PLA2G2E, PLA2G2A"], ["545273", "Glycoaminoglycan-protein linkage region biosynthesis", "1.05E − 01", "2.53E − 01", "8.24E − 01", "1.00E + 00", "1", "B3GAT1"], ["545323", "Urate biosynthesis/inosine 5′-phosphate degradation", "1.05E − 01", "2.53E − 01", "8.24E − 01", "1.00E + 00", "1", "NT5E"], ["142383", "Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde", "1.21E − 01", "2.53E − 01", "8.24E − 01", "1.00E + 00", "1", "IDO1"], ["KEGG", "", "", "", "", "", "", ""], ["83051", "Cytokine-cytokine receptor interaction", "3.05E − 61", "5.54E − 59", "3.21E − 58", "5.54E − 59", "69", "IL10, IL10RA, IL12A, IL12B, IL13, IL13RA1, TNFRSF9, IL17A, PDGFB, TNFSF12, IL17B, TNFRSF14, TNFRSF10C, CCL26,IL17F, TNFRSF4, IL22RA2, IL21, CCL7, CCR6, CCL11, CCL13, CCR8, CCL15, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, KIT, CX3CL1, CXCL12, IL19, CCR10, XCR1, CXCL13, PPBP, IL23A, IFNA2, IFNAR1, IFNB1, IFNG, TGFBR1, LIF, CSF1R, CSF2, CSF2RB, CSF3R, IL20, IL22,, CD40, TNFRSF13C, LTA, IL1RAP, IL2, IL3, IL4, IL4R, IL5, IL6, IL6R, IL7, IL26, CXCR1, IL9, CXCR2"], ["83078", "Hematopoietic cell lineage", "4.22E − 35", "3.84E − 33", "2.22E − 32", "7.67E − 33", "34", "HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, CD55, MME, KIT, CR2, TFRC, CD1A, CD3E, CSF1R, CSF2, CD8A, CD9, CSF3R, CD19, MS4A1, CD22, CD34, CD44, CD59, IL3, IL4, IL4R, IL5, IL6, IL6R, IL7"], ["842771", "Inflammatory bowel disease (IBD)", "4.58E − 32", "2.78E − 30", "1.61E − 29", "8.34E − 30", "28", "IL10, IL12A, IL12B, IL13, IL17A, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, GATA3, IL17F, STAT6, IL21, RELA, IL23A, IFNG, IL22, RORC, IL2, IL4, IL4R, IL5, IL6"], ["83077", "Jak-STAT signaling pathway", "4.56E − 26", "1.19E − 24", "6.86E − 24", "8.30E − 24", "33", "IL10, IL10RA, IL12A, IL12B, IL13, IL13RA1, BCL2, STAT5A, STAT6, PTPN6, IL22RA2, IL21, IL19, IL23A, IFNA2, IFNAR1, IFNB1, IFNG, LIF, CSF2, CSF2RB, CSF3R, IL20, IL22, IL2, IL3, IL4, IL4R, IL5, IL6, IL6R, IL7, IL9"], ["213780", "Tuberculosis", "3.41E − 25", "6.89E − 24", "3.99E − 23", "6.20E − 23", "34", "IL10, IL10RA, IL12A, IL12B, CEBPB, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, BCL2, CD209, BID, FCGR2A, FCGR2B, CARD9, NOS2, CASP3, RELA, TLR9, IL23A, IFNA2, IFNB1, IFNG, TIRAP, IRAK4, CD74, MAPK11, CTSS, IL6"], ["83120", "Asthma", "4.56E − 24", "8.30E − 23", "4.80E − 22", "8.30E − 22", "18", "IL10, IL13, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, FCER1A, CCL11, CD40, IL3, IL4, IL5, IL9"], ["125138", "Viral myocarditis", "2.26E − 16", "2.06E − 15", "1.19E − 14", "4.12E − 14", "17", "HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, CD55, BID, CASP3, CD80, CD86, CD40"], ["373901", "HTLV-I infection", "2.85E − 15", "2.35E − 14", "1.36E − 13", "5.18E − 13", "29", "HLA-B, PDGFB, HLA-C, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, ETS1, STAT5A, VCAM1, RELA, RELB, LCK, SLC2A1, TGFBR1, CD3E, CSF2, EGR1, EGR2, CD40, TNFRSF13C, LTA, IL2, IL6"], ["213306", "Measles", "4.04E − 12", "2.53E − 11", "1.47E − 10", "7.35E − 10", "19", "IL12A, IL12B, IL13, CD46, TNFRSF10C, CD209, STAT5A, FCGR2B, RELA, TLR9, IFNA2, IFNAR1, IFNB1, IFNG, CD3E, IRAK4, IL2, IL4, IL6"], ["83074", "Antigen processing and presentation", "7.12E − 12", "4.32E − 11", "2.50E − 10", "1.30E − 09", "15", "HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, IFNG, CD8A, CD74, CTSS"], ["217173", "Influenza A", "4.98E − 11", "2.75E − 10", "1.59E − 09", "9.07E − 09", "20", "IL12A, IL12B, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1,HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, TNFRSF10C, RELA, IFNA2, IFNAR1, IFNB1, IFNG, IRAK4, MAPK11, IL6"], ["Pathway interaction database", "", "", "", "", "", "", ""], ["137933", "IL4-mediated signaling events", "7.74E − 16", "8.36E − 14", "4.40E − 13", "8.36E − 14", "17", "IL10, IL13RA1, CEBPB, AICDA, ETS1, CCL26, STAT5A, STAT6, PTPN6, PIGR, CCL11, THY1, EGR2, LTA, IL4, IL4R, IL5"], ["137922", "IL12-mediated signaling events", "9.23E − 15", "4.99E − 13", "2.62E − 12", "9.97E − 13", "16", "IL12A, IL12B, HLA-DRA, HLA-DRB1, STAT5A, STAT6, EOMES, NOS2, RELA, RELB, LCK, IFNG, CD3E, CD8A, IL2, IL4"], ["138000", "IL23-mediated signaling events", "1.32E − 12", "4.75E − 11", "2.50E − 10", "1.42E − 10", "12", "IL12B, IL17A, IL17F, STAT5A, NOS2, IL19, RELA, IL23A, IFNG, CD3E, IL2, IL6"], ["137929", "IL27-mediated signaling events", "1.43E − 11", "3.87E − 10", "2.04E − 09", "1.55E − 09", "10", "IL12A, IL12B, IL17A, GATA3, STAT5A, IFNG, EBI3, IL2, IL6, IL27"], ["138058", "BCR signaling pathway", "3.00E − 07", "4.05E − 06", "2.13E − 05", "3.24E − 05", "10", "ETS1, PTPN6, FCGR2B, BTK, POU2F2, RELA, CD19, CD22, CD79A, CD79B"], ["138055", "TCR signaling in naive CD8 + T cells", "2.28E − 04", "1.30E − 03", "6.82E − 03", "2.46E − 02", "6", "PTPN6, LCK, CD3E, CD8A, CD80, CD86"], ["137939", "Direct p53 effectors", "2.95E − 03", "1.33E − 02", "7.00E − 02", "3.18E − 01", "8", "SPP1, BCL2, TNFRSF10C, BID, CD82, MAP4K4, CX3CL1, LIF"], ["138081", "FAS (CD95) signaling pathway", "3.67E − 03", "1.42E − 02", "7.46E − 02", "3.97E − 01", "4", "BID, BTK, CASP3, MAPK11"], ["137995", "HIV-1 Nef: Negative effector of Fas and TNF-alpha", "3.67E − 03", "1.42E − 02", "7.46E − 02", "3.97E − 01", "4", "BCL2, BID, CASP3, RELA"], ["137944", "IL1-mediated signaling events", "2.58E − 02", "6.45E − 02", "3.40E − 01", "1.00E + 00", "3", "TOLLIP, RELA, IRAK4"], ["REACTOME", "", "", "", "", "", "", ""], ["1269310", "Cytokine Signaling in Immune system", "3.81E − 46", "2.02E − 43", "1.39E − 42", "2.02E − 43", "86", "IL10, IL10RA, IL12A, IL12B, IL13, IL13RA1, IL16, TRAF3, TNFRSF9, IL17A, HLA-B, PDGFB, HLA-C, TNFSF12, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, TNFRSF14, GATA3, PSMB10, BCL2, PTAFR, IL1RL2, IL17F, PTK2, STAT5A, STAT6, TNFRSF4, PTPN6, IL22RA2, TOLLIP, CCL11, CCL19, CCL20, CCL22, KIT, NOS2, VCAM1, IL19, RAG1, RAG2, ZEB1, FN1, DUSP4, IRF8, CASP3, RELA, RELB, LCK, IL23A, S1PR1, IFNA2, IFNAR1, IFNB1, IFNG, LIF, CSF1R, CSF2, CSF2RB, CSF3R, EBI3, EGR1, IL20, CD80, CD86, IL22, CD40, IRAK4, CD44, TNFRSF13C, LTA, RORC, IL1RAP, IL2, IL3, IL4, IL4R, IL5, IL6, IL6R, IL7, IL27, IL9"], ["1269318", "Signaling by Interleukins", "2.98E − 33", "7.91E − 31", "5.42E − 30", "1.58E − 30", "62", "IL10, IL10RA, IL12A, IL12B, IL13, IL13RA1, IL16, IL17A, PDGFB, GATA3, PSMB10, BCL2, PTAFR, IL1RL2, IL17F, PTK2, STAT5A, STAT6, PTPN6, IL22RA2, TOLLIP, CCL11, CCL19, CCL20, CCL22, KIT,NOS2, VCAM1, IL19, RAG1, RAG2, ZEB1, FN1, DUSP4, CASP3, RELA, LCK, IL23A, S1PR1, LIF, CSF1R, CSF2, CSF2RB, CSF3R, EBI3, IL20, CD80, CD86, IL22, IRAK4, RORC, IL1RAP, IL2, IL3, IL4, IL4R, IL5, IL6, IL6R,IL7, IL27, IL9"], ["1269203", "Innate Immune System", "4.93E − 25", "8.72E − 23", "5.98E − 22", "2.62E − 22", "82", "MASP1, TRAF3, HLA-B, PDGFB, HLA-C, MAPKAPK2, CTSC, PECAM1, MBL2, PSMB10, CD55, CD46, BCL2, DEFB103B, PTAFR, CD209, PTK2, STAT6, DEFB1, DEFB4A, CFD, PTPN6, FCAR, FCER1A, PIGR, FCGR2A, CARD9, BTK, MIF, PLA2G2A, TOLLIP, C1R, C1S, C4A, PLAU, C4BPA, CCR6, MME, C6, C7, C8A, C8B, C9, KIT, NOS2, GPI, LILRA3, VTN, CLEC6A, FN1, ATG7, ITLN1, DUSP4, ICAM2, ICAM3, RELA, RELB, TLR9, LCK, PPBP, CFI, IFNA2, LGALS3, IFNB1, CSF2, CSF2RB, CD19, SIGIRR, CD80, CD86, TIRAP, IRAK4, CD44, CD59, MAPK11, IL2, IL3, IL5, CTSS, CXCR1, MASP2, CXCR2"], ["1269171", "Adaptive Immune System", "1.51E − 15", "1.15E − 13", "7.86E − 13", "8.03E − 13", "52", "HLA-B, PDGFB, HLA-C, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, CTSC, HLA-DRB1, TNFRSF14, PSMB10, PTPN22, CD209, PTPN6, SLAMF6, FCGR2B, BTK, KIT, KLRB1, LILRB5, VCAM1, ICOSLG, LILRA1, LILRA3, LILRA2, ATG7, ICAM2, ICAM3, ICAM4, RELA, BTLA, LCK, CD1A, CD3E, CD8A, CD19, CD22, CD80, CD86, ICAM5, TIRAP, CD34, CD40, CD74, CD79A, CD79B, CTLA4, CTSS"], ["1269201", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "5.01E − 14", "2.66E − 12", "1.82E − 11", "2.66E − 11", "21", "HLA-B, HLA-C, SLAMF6, FCGR2B, KLRB1, LILRB5, VCAM1, LILRA1, LILRA3, LILRA2, ICAM2, ICAM3, ICAM4, CD1A, CD3E, CD8A, CD19, CD22, ICAM5, CD34, CD40"], ["1269546", "Peptide ligand-binding receptors", "6.17E − 08", "1.82E − 06", "1.25E − 05", "3.27E − 05", "17", "CCR6, CCL13, CCR8, CCL16, CCL19, CCL20, CXCL11, XCL1, CX3CL1, CXCL12, CCR10, XCR1, CXCL13, PPBP, EDNRB, CXCR1, CXCR2"], ["1269545", "Class A/1 (Rhodopsin-like receptors)", "4.71E − 07", "1.14E − 05", "7.79E − 05", "2.50E − 04", "21", "PTAFR, PTGER4, CCR6, CCL13,CCR8,CCL16, CCL19, CCL20, CXCL11, XCL1, CX3CL1, CXCL12, CCR10, XCR1, CXCL13, GPR183, PPBP, S1PR1, EDNRB, CXCR1, CXCR2"], ["1269340", "Hemostasis", "1.15E − 04", "1.47E − 03", "1.01E − 02", "6.09E − 02", "26", "CD244, PDGFB, PECAM1, GATA3, PTK2, CFD, PTPN6, MIF, PLAU, NOS2, SELE, SELPLG, FN1, LCK, PPBP, IFNA2, IFNB1, CSF2, CSF2RB, CD9, CD44, CD48, CD74, IL2, IL3, IL5"], ["1269501", "MAPK family signaling cascades", "3.27E − 04", "3.40E − 03", "2.33E − 02", "1.74E − 01", "15", "PDGFB, PSMB10, PTK2, KIT, RAG1, RAG2, FN1, DUSP4, CSF2, CSF2RB, IL2, IL3, IL5, IL6, IL6R"], ["1269240", "Toll Like Receptor TLR6:TLR2 Cascade", "3.46E − 04", "3.40E − 03", "2.33E − 02", "1.84E − 01", "8", "MAPKAPK2, BTK, DUSP4, RELA, SIGIRR, TIRAP, IRAK4, MAPK11"], ["Gen MAPP", "", "", "", "", "", "", ""], ["MAP00400", "Phenylalanine tyrosine and tryptophan biosynthesis", "1.38E − 01", "5.02E − 01", "1.00E + 00", "1.00E + 00", "1", "BID"], ["MAP_kinase_activity", "MAP kinase activity", "1.38E − 01", "5.02E − 01", "1.00E + 00", "1.00E + 00", "1", "MAPK11"], ["MAP00010", "Glycolysis Gluconeogenesis", "2.47E − 01", "5.02E − 01", "1.00E + 00", "1.00E + 00", "2", "BID, GPI"], ["MAP00030", "Pentose phosphate", "2.70E − 01", "5.02E − 01", "1.00E + 00", "1.00E + 00", "1", "GPI"], ["MAP00590", "Prostaglandin and leukotriene metabolism", "2.96E − 01", "5.02E − 01", "1.00E + 00", "1.00E + 00", "1", "PLA2G2A"], ["MAP00500", "Starch and sucrose metabolism", "3.34E − 01", "5.02E − 01", "1.00E + 00", "1.00E + 00", "1", "GPI"], ["MAP00330", "Arginine and proline metabolism", "5.05E − 01", "5.81E − 01", "1.00E + 00", "1.00E + 00", "1", "NOS2"], ["MAP00380", "Tryptophan metabolism", "5.73E − 01", "5.81E − 01", "1.00E + 00", "1.00E + 00", "1", "IDO1"], ["MAP00561", "Glycerolipid metabolism", "5.81E − 01", "5.81E − 01", "1.00E + 00", "1.00E + 00", "1", "PLA2G2A"], ["MSigDB C2 BIOCARTA (v6.0)", "", "", "", "", "", "", ""], ["M5883", "Genes encoding secreted soluble factors", "4.86E − 27", "7.82E − 25", "4.43E − 24", "7.82E − 25", "46", "IL10, IL12A, IL12B, IL13, IL16, IL17A, PDGFB, TNFSF12, IL17B, CCL26, IL17F, CCL7, CCL11, CCL13, CCL15, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, CX3CL1, CXCL12, IL19, CXCL13, PPBP, IL23A, IFNA2, IFNB1, IFNG, LIF, CSF2, EBI3, IL20, IL22, LTA, IL2, IL3, IL4, IL5, IL6, IL7, IL26, IL9"], ["M17406", "Cytokine Network", "2.71E − 22", "2.18E − 20", "1.24E − 19", "4.36E − 20", "15", "IL10, IL12A, IL12B, IL13, IL16, IL17A, IFNB1, IFNG, LTA, IL2, IL3, IL4, IL5, IL6, IL9"], ["M6910", "Cytokines and Inflammatory Response", "5.19E − 21", "2.78E − 19", "1.58E − 18", "8.35E − 19", "16", "IL10, IL12A, IL12B, IL13, HLA-DRA, HLA-DRB1, IFNB1, IFNG, CSF2, LTA, IL2, IL3, IL4, IL5, IL6, IL7"], ["M5885", "Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors", "7.80E − 21", "3.14E − 19", "1.78E − 18", "1.26E − 18", "57", "IL10, IL12A, IL12B, IL13, MASP1, IL16, IL17A, PDGFB, TNFSF12, CTSC, IL17B, MBL2, CCL26, IL17F, CD209, PLAU, CCL7, CCL11, CCL13, CCL15, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, CX3CL1, CXCL12, IL19, CLEC6A, ITLN1, CXCL13, ITLN2, PPBP, IL23A, IFNA2, LGALS3, IFNB1, IFNG, LIF, CSF2, EBI3, IL20, IL22, LTA, IL2, IL3, IL4, IL5, CTSS, IL6, IL7, IL26, IL9, MASP2"], ["M5889", "Ensemble of genes encoding extracellular matrix and extracellular matrix-associated proteins", "4.62E − 17", "1.49E − 15", "8.43E − 15", "7.44E − 15", "61", "IL10, IL12A, IL12B, IL13, MASP1, IL16, IL17A, PDGFB, TNFSF12, SPP1, CTSC,IL17B, MBL2, CCL26, IL17F, CD209, PLAU, CCL7,CCL11, CCL13, CCL15,CCL16, CCL18, CCL19, CCL20,CCL22, CCL24, CXCL11,XCL1, CX3CL1, CXCL12, IL19, VTN,CLEC6A, FN1, ITLN1, CXCL13,ITLN2, PPBP, IL23A,IFNA2, LGALS3, IFNB1, IFNG, TGFBI, LIF, CSF2, EBI3, IL20, IL22, LTA, IL2, IL3, IL4, IL5, CTSS, IL6, IL7, IL26, IL9, MASP2"], ["M1467", "The Co-Stimulatory Signal During T-cell Activation", "4.81E − 11", "7.03E − 10", "3.98E − 09", "7.74E − 09", "9", "HLA-DRA, HLA-DRB1, ICOSLG, LCK, CD3E, CD80, CD86, CTLA4, IL2"], ["M3952", "Cells and Molecules involved in local acute inflammatory response", "1.02E − 05", "7.46E − 05", "4.22E − 04", "1.64E − 03", "5", "C6, C7, VCAM1, SELPLG,IL6"], ["M18215", "Role of Tob in T-cell activation", "3.16E − 05", "2.21E − 04", "1.25E − 03", "5.08E − 03", "5", "IFNG, TGFBR1, CD3E, IL2, IL4"], ["M13968", "HIV-I Nef: negative effector of Fas and TNF", "6.46E − 04", "3.15E − 03", "1.78E − 02", "1.04E − 01", "6", "BCL2,PTK2, BID, CASP3, RELA, ARHGDIB"], ["M13247", "T Cytotoxic Cell Surface Molecules", "1.90E − 03", "6.80E − 03", "3.85E − 02", "3.06E − 01", "3", "CD3E, CD8A, THY1"], ["Panther DB", "", "", "", "", "", "", ""], ["P00036", "Interleukin signaling pathway", "6.51E − 19", "2.47E − 17", "1.05E − 16", "2.47E − 17", "22", "IL10,IL10RA, IL12A,IL13, IL13RA1, IL17A, MAPKAPK2, IL17F, STAT5A, STAT6, IL21, IL23A, IL2, IL4, IL4R, IL5, IL6, IL6R, IL7, CXCR1, IL9, CXCR2"], ["P00031", "Inflammation mediated by chemokine and cytokine signaling pathway", "4.36E − 07", "8.28E − 06", "3.50E − 05", "1.66E − 05", "16", "CCL26, CCL7, CCR6, CCL11, CCL13, CCR8, CCL18, CCL20, CCL22, CX3CL1, CCR10, XCR1, IFNAR1, IFNG, CXCR1, CXCR2"], ["P00053", "T cell activation", "7.23E − 05", "8.13E − 04", "3.44E − 03", "2.75E − 03", "8", "HLA-DPA1, HLA-DQA1, HLA-DRA, LCK, CD3E, CD80, CD86, CD74"], ["P00010", "B cell activation", "8.56E − 05", "8.13E − 04", "3.44E − 03", "3.25E − 03", "7", "PTPN6, BTK, CD19, CD22, CD79A, CD79B, MAPK11"], ["P00054", "Toll receptor signaling pathway", "2.14E − 03", "1.62E − 02", "6.86E − 02", "8.12E − 02", "5", "TOLLIP, RELA, TLR9, IFNB1, IRAK4"], ["P00006", "Apoptosis signaling pathway", "2.67E − 03", "1.69E − 02", "7.14E − 02", "1.01E − 01", "7", "BCL2, BID, BCL2L11, CASP3, RELA, RELB, LTA"], ["P00035", "Interferon-gamma signalingpathway", "1.42E − 02", "7.69E − 02", "3.25E − 01", "5.39E − 01", "3", "PTPN6, IFNG, MAPK11"], ["P00046", "Oxidative stress response", "5.17E − 02", "1.86E − 01", "7.88E − 01", "1.00E + 00", "3", "BCL2, DUSP4, MAPK11"], ["P00047", "PDGF signaling pathway", "8.39E − 02", "2.44E − 01", "1.00E + 00", "1.00E + 00", "5", "PDGFB, MAPKAPK2, ETS1, STAT5A, STAT6"], ["P00034", "Integrin signalling pathway", "5.94E − 01", "7.28E − 01", "1.00E + 00", "1.00E + 00", "3", "ITGAE, PTK2, FN1"], ["Pathway Ontology", "", "", "", "", "", "", ""], ["PW:0000104", "intrinsic apoptotic", "1.82E − 03", "7.63E − 02", "3.30E − 01", "7.63E − 02", "4", "BCL2, BID, BCL2L11, CASP3"], ["PW:0000515", "Interleukin-10 signaling", "7.84E − 01", "1.57E − 01", "6.78E − 01", "6.78E − 01", "1", "IL10"], ["PW:0000516", "Interleukin-6 signaling", "7.84E − 01", "1.57E − 01", "6.78E − 01", "6.78E − 01", "1", "IL6"], ["PW:0000499", "Nuclear Factor Kappa B signaling", "9.58E − 01", "1.60E − 01", "6.91E − 01", "6.91E − 01", "2", "RELA, RELB"], ["PW:0000009", "programmed cell death", "1.00E + 00", "1.80E − 01", "7.78E − 01", "7.78E − 01", "2", "BCL2, CASP3"], ["PW:0000102", "The extracellular signal-regulated RAF/MEK/ERK signaling", "8.14E − 02", "2.18E − 01", "9.44E − 01", "1.00E + 00", "2", "SPP1, S1PR1"], ["PW:0000529", "angiotensin (1-7) signaling", "8.83E − 02", "2.18E − 01", "9.44E − 01", "1.00E + 00", "1", "MME"], ["PW:0000106", "extrinsic apoptotic", "1.05E − 01", "2.45E − 01", "1.00E + 00", "1.00E + 00", "1", "CASP3"], ["PW:0000559", "hexosamine biosynthetic", "1.21E − 01", "2.55E − 01", "1.00E + 00", "1.00E + 00", "1", "GPI"], ["PW:0000228", "G protein signaling via Galphai family", "1.53E − 01", "2.80E − 01", "1.00E + 00", "1.00E + 00", "1", "S1PR1"], ["SMPDB", "", "", "", "", "", "", ""], ["SMP00094", "Sulindac Pathway", "1.21E − 01", "4.52E − 01", "1.00E + 00", "1.00E + 00", "1", "PLA2G2A"], ["SMP00040", "Glycolysis", "2.14E − 01", "4.52E − 01", "1.00E + 00", "1.00E + 00", "1", "GPI"], ["SMP00063", "Tryptophan Metabolism", "2.70E − 01", "4.52E − 01", "1.00E + 00", "1.00E + 00", "1", "IDO1"], ["SMP00379", "NifedipinePathway", "2.83E − 01", "4.52E − 01", "1.00E + 00", "1.00E + 00", "1", "EDNRB"], ["SMP00006", "Tyrosine Metabolism", "3.59E − 01", "4.84E − 01", "1.00E + 00", "1.00E + 00", "1", "MIF"], ["SMP00320", "Intracellular Signalling Through Adenosine Receptor A2a and Adenosine", "4.57E − 01", "4.84E − 01", "1.00E + 00", "1.00E + 00", "1", "MAPK11"]], "row_count": 91, "column_count": 8, "numeric_cells": 544, "header_rows": 2, "locator": "section[13]/table-wrap[2]#Tab3"}}, {"id": "asset:table:pmid:33251083:4", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:3d0cc2025b76ce360a2ebcd6f7a40ea02ca2add666d309680d150a2f033eabd0", "bytes": 8645, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[14]/table-wrap[1]#Tab4", "version": null, "note": "The enriched GO terms of the up regulated differentially expressed genes", "structure": {"pmcid": "PMC7679428", "section_index": 6, "section_title": "Gene ontology (GO) enrichment analysis for DEGs", "row_count": 31, "column_count": 9}, "table": {"label": "Table 4", "caption": "The enriched GO terms of the up regulated differentially expressed genes", "rows": [["GO ID", "CATEGORY", "GO Name", "P Value", "FDR B&H", "FDR B&Y", "Bonferroni", "Gene Count", "Gene"], ["GO:0002682", "BP", "Regulation of immune system process", "1.53E − 44", "5.68E − 41", "5.00E − 40", "5.68E − 41", "56", "KLRK1, ATG5, JAK1, JAK2, IFIH1, PDCD1, TRAF2, TRAF6, IKZF3, CD247, ZBTB16, ABL1, HLA-A, IKBKE, CD99, BST2, LILRB2, TBX21, TLR2, LAG3, HRAS, PSMB9, C1QBP, CLEC7A, SERPING1, XBP1, GBP1, SOCS1, C2, CCR1, IKZF1, CCL5, IRF7, CTNNB1, RUNX1, SLAMF7, IKBKB, LCP2, ITGAL, FYN, IL18RAP, ITGB2, IL2RG, IL18R1, KLRC1, ZAP70, GFI1, KLRD1, CX3CR1, STAT1, TP53, NLRP3, STAT3, STAT5B, CEACAM1, IFNAR2"], ["GO:0009607", "BP", "Response to biotic stimulus", "6.86E − 35", "6.36E − 32", "5.59E − 31", "2.54E − 31", "48", "KLRK1, ATG5, JAK1, JAK2, IFIH1, TRAF6, IKZF3, ATG10, ABL1, HLA-A, IKBKE, BST2, LILRB2, TBX21, TLR2, GZMB, LAG3, HRAS, PSMB9, C1QBP, CLEC7A, SERPING1, XBP1, GBP1, SOCS1, C2, IRF5, CCL5, IRF7, CCR5, GNLY, SLAMF7, IKBKB, FYN, IFI35, IL18RAP, ITGB2, MAP4K2, GFI1, KLRD1, CX3CR1, STAT1, TP53, NLRP3, MX1, STAT5B, CEACAM1, IFNAR2"], ["GO:0006952", "BP", "Defense response", "1.12E − 33", "5.92E − 31", "5.21E − 30", "4.14E − 30", "49", "KLRK1, JAK1, JAK2, IFIH1, TRAF6, HLA-A, IKBKE, BST2, LILRB2, TLR2, GZMB, LAG3, HRAS, PSMB9, C1QBP, CLEC7A, SERPING1, GBP1, CCRL2, SOCS1, C2, CCR1, IRF5, CCL5, IRF7, CCR5, GNLY, LTB4R, SLAMF7, IKBKB, ITGAL, FYN, IFI35, IL18RAP, ITGB2, IL18R1, MAP4K2, GFI1, KLRD1, CX3CR1, STAT1, TP53, NLRP3, STAT3, STAT4, MX1, STAT5B, CEACAM1, IFNAR2"], ["GO:0001816", "BP", "Cytokine production", "3.84E − 27", "1.29E − 24", "1.14E − 23", "1.42E − 23", "34", "KLRK1, ATG5, JAK2, IFIH1, TRAF2, TRAF6, CD247, ABL1, IKBKE, BST2, LILRB2, TBX21, TLR2, LAG3, HRAS, C1QBP, CLEC7A, XBP1, GBP1, SOCS1, IRF5, CCL5, IRF7, CTNNB1, RUNX1, LCP2, IL18RAP, IL18R1, CX3CR1, STAT1, NLRP3, STAT3, STAT5B, CEACAM1"], ["GO:0034097", "BP", "Response to cytokine", "2.23E − 26", "6.90E − 24", "6.07E − 23", "8.28E − 23", "38", "JAK1, JAK2, IFIH1, TRAF2, TRAF6, HLA-A, IKBKE, BST2, TLR2, PSMB9, XBP1, GBP1, CCRL2, SOCS1, CCR1, IRF5, CCL5, IRF7, CCR5, CTNNB1, RUNX1, IKBKB, FYN, IFI35, IL18RAP, ITGB2, IL2RG, IL18R1, GFI1, CX3CR1, STAT1, TP53, STAT3, STAT4, MX1, STAT5B, CEACAM1, IFNAR2"], ["GO:0042110", "BP", "T cell activation", "1.68E − 25", "4.43E − 23", "3.90E − 22", "6.21E − 22", "28", "CCND3, KLRK1, ATG5, PDCD1, TRAF6, ZBTB16, ABL1, LILRB2, TBX21, LAG3, CLEC7A, XBP1, SOCS1, IKZF1, CCL5, CTNNB1, RUNX1, ITGAL, FYN, ITGB2, IL2RG, IL18R1, ZAP70, TP53, NLRP3, STAT3, STAT5B, CEACAM1"], ["GO:0045321", "BP", "Leukocyte activation", "6.65E − 23", "1.30E − 20", "1.14E − 19", "2.47E − 19", "36", "CCND3, KLRK1, ATG5, JAK2, PDCD1, TRAF6, IKZF3, ZBTB16, ABL1, BST2, LILRB2, TBX21, TLR2, LAG3, CLEC7A, XBP1, SOCS1, IKZF1, CCL5, CTNNB1, RUNX1, SLAMF7, LCP2, ITGAL, FYN, IL18RAP, ITGB2, IL2RG, IL18R1,ZAP70, CX3CR1,TP53, NLRP3, STAT3, STAT5B, CEACAM1"], ["GO:0001775", "BP", "Cell activation", "2.83E − 22", "5.00E − 20", "4.40E − 19", "1.05E − 18", "37", "CCND3, KLRK1, ATG5, JAK2, PDCD1, TRAF6, IKZF3, ZBTB16, ABL1, BST2, LILRB2, TBX21, TLR2, LAG3, CLEC7A, XBP1, SOCS1, IKZF1, CCL5, CTNNB1, RUNX1, SLAMF7, LCP2, ITGAL, FYN, IL18RAP, ITGB2, IL2RG, IL18R1, ZAP70, CX3CR1, TP53, NLRP3, STAT3, STAT5B, CEACAM1, GP1BB"], ["GO:0080134", "BP", "Regulation of response to stress", "3.88E − 18", "3.59E − 16", "3.16E − 15", "1.44E − 14", "34", "KLRK1, JAK1, JAK2, IFIH1, TRAF2, TRAF6, ABL1, IKBKE, MAP4K1, TLR2, LAG3, HRAS, PSMB9, C1QBP, CLEC7A, SERPING1, XBP1, SOCS1, CCL5, IRF7, CTNNB1, IKBKB, FYN, IL18RAP, ITGB2, MAP4K2, GFI1, CX3CR1, STAT1, TP53, NLRP3, STAT5B, CEACAM1, IFNAR2"], ["GO:0051094", "BP", "Positive regulation of developmental process", "1.52E − 15", "1.00E − 13", "8.79E − 13", "5.64E − 12", "31", "JAK1, JAK2, TRAF6, ZBTB16, ABL1, LILRB2, TBX21, TLR2, C1QBP, CLEC7A, XBP1, SOCS1, CCR1, IKZF1, CCL5, CTNNB1, RUNX1, IKBKB, FYN, ITGB2, IL2RG, ZAP70, GFI1, CX3CR1, STAT1, TP53, NLRP3, STAT3, STAT5B, SMAD5, CEACAM1"], ["GO:0098552", "CC", "Side of membrane", "1.17E − 11", "1.54E − 09", "9.47E − 09", "3.08E − 09", "18", "KLRK1, PDCD1, TRAF2, TRAF6, HLA-A, TLR2, LAG3, CCRL2, CCR1, CCR5, SLAMF7, IKBKB, ITGAL, FYN, ITGB2, IL2RG, KLRD1, CX3CR1"], ["GO:0043235", "CC", "Receptor complex", "3.20E − 10", "2.81E − 08", "1.73E − 07", "8.44E − 08", "15", "TRAF2, TRAF6, CD247, TLR2, IKBKB, LCP2, ITGAL, IL18RAP, ITGB2, IL2RG, IL18R1, KLRC1, ZAP70, KLRD1, CEACAM1"], ["GO:0009986", "CC", "Cell surface", "2.20E − 09", "9.68E − 08", "5.96E − 07", "5.81E − 07", "19", "KLRK1, PDCD1, HLA-A, BST2, LILRB2, TLR2, LAG3, C1QBP, CLEC7A, CCRL2, CCR1, CCR5, SLAMF7, ITGAL, ITGB2, IL2RG, KLRD1, CX3CR1, CEACAM1"], ["GO:0005887", "CC", "Integral component of plasma membrane", "2.88E − 07", "6.90E − 06", "4.25E − 05", "7.59E − 05", "21", "KLRK1, TRAF2, TRAF6, CD99, LILRB2, TLR2, CCRL2, CCR1, CCR5, LTB4R, IKBKB, ITGAL, IL18RAP, ITGB2, IL2RG, IL18R1, KLRC1, CX3CR1, CEACAM1, GP1BB, IFNAR2"], ["GO:0098805", "CC", "Whole membrane", "8.24E − 06", "1.55E − 04", "9.56E − 04", "2.18E − 03", "19", "ATG5, JAK2, TRAF2, TRAF6, HLA-A, IKBKE, BST2, LILRB2, TLR2, IRF7, LTB4R, CTNNB1, IKBKB, LCP2, ITGAL, FYN, ITGB2, ZAP70, CEACAM1"], ["GO:0044194", "CC", "cytolytic granule", "1.84E − 04", "2.70E − 03", "1.66E − 02", "4.87E − 02", "2", "GZMB, GNLY"], ["GO:0000790", "CC", "Nuclear chromatin", "9.72E − 04", "1.17E − 02", "7.18E − 02", "2.57E − 01", "16", "IKZF3, ZBTB16, TBX21, XBP1, IRF5, IKZF1, IRF7, CTNNB1, RUNX1, GFI1, STAT1, TP53, STAT3, STAT4, STAT5B, SMAD5"], ["GO:0090575", "CC", "RNA polymerase II transcription factor complex", "5.30E − 03", "4.21E − 02", "2.59E − 01", "1.00E + 00", "4", "CTNNB1, RUNX1, TP53, STAT3"], ["GO:0005667", "CC", "Transcription factor complex", "5.46E − 03", "4.21E − 02", "2.59E − 01", "1.00E + 00", "6", "IKZF1, CTNNB1, RUNX1, TP53, STAT3, SMAD5"], ["GO:0048471", "CC", "Perinuclear region of cytoplasm", "8.69E − 03", "4.78E − 02", "2.94E − 01", "1.00E + 00", "8", "TRAF6, ABL1, HRAS, CTNNB1, FYN, CX3CR1, STAT1, MX1"], ["GO:0019900", "MF", "Kinase binding", "6.20E − 10", "1.90E − 07", "1.27E − 06", "2.82E − 07", "19", "CCND3, KLRK1, JAK2, TRAF2, TRAF6, CD247, ABL1, C1QBP, XBP1, SOCS1, CCL5, CTNNB1, IKBKB, ITGB2, MAP4K2, TP53, STAT3, CEACAM1, IFNAR2"], ["GO:0005102", "MF", "Signaling receptor binding", "7.06E − 08", "3.57E − 06", "2.39E − 05", "3.21E − 05", "23", "KLRK1, JAK1, JAK2, TRAF2, TRAF6, ABL1, HLA-A, LILRB2, TLR2, LAG3, C1QBP, CLEC7A, CCRL2, SOCS1, CCL5, CTNNB1, FYN, ITGB2, KLRD1, STAT1, TP53, STAT3, STAT5B"], ["GO:0044212", "MF", "Transcription regulatory region DNA binding", "1.45E − 07", "5.42E − 06", "3.63E − 05", "6.57E − 05", "17", "TRAF6, IKZF3, ZBTB16, TBX21, XBP1, IRF5, IKZF1, IRF7, CTNNB1, RUNX1, GFI1, STAT1, TP53, STAT3, STAT4, STAT5B, SMAD5"], ["GO:0038023", "MF", "Signaling receptor activity", "3.46E − 07", "1.13E − 05", "7.54E − 05", "1.58E − 04", "21", "KLRK1, CD247, LILRB2, TLR2, LAG3, CLEC7A, CCRL2, CCR1, CCL5, CCR5, LTB4R, ITGAL, IL18RAP, ITGB2, IL2RG, IL18R1, KLRC1, KLRD1, CX3CR1, GP1BB, IFNAR2"], ["GO:0043565", "MF", "Sequence-specific double-stranded DNA binding", "5.76E − 06", "9.35E − 05", "6.27E − 04", "2.62E − 03", "16", "IKZF3, ZBTB16, ABL1, TBX21, XBP1, IRF5, IKZF1, IRF7, RUNX1, STAT1, TP53, NLRP3, STAT3, STAT4, STAT5B, SMAD5"], ["GO:0016772", "MF", "Transferase activity, transferring phosphorus-containing groups", "8.11E − 06", "1.19E − 04", "7.98E − 04", "3.69E − 03", "20", "CCND3, JAK1, JAK2, TRAF2, TRAF6, ABL1, IKBKE, MAP4K1, HRAS, SOCS1, CCL5, CTNNB1, IKBKB, LCP2, FYN, ZAP70, MAP4K2, TP53, STAT3, CEACAM1"], ["GO:0070011", "MF", "Peptidase activity, acting on L-amino acid peptides", "1.03E − 05", "1.38E − 04", "9.27E − 04", "4.66E − 03", "16", "ATG5, JAK2, IFIH1, TRAF2, TRAF6, BST2, GZMB, PSMB9, CLEC7A, SERPING1, C2, FYN, STAT1, TP53, NLRP3, STAT3"], ["GO:0000977", "MF", "RNA polymerase II regulatory region sequence-specific DNA binding", "1.25E − 05", "1.58E − 04", "1.06E − 03", "5.67E − 03", "13", "IKZF3, ZBTB16, TBX21, XBP1, IKZF1, IRF7, RUNX1, STAT1, TP53, STAT3, STAT4, STAT5B, SMAD5"], ["GO:0035639", "MF", "Purine ribonucleoside triphosphate binding", "3.00E − 04", "1.75E − 03", "1.17E − 02", "1.37E − 01", "17", "JAK1, JAK2, IFIH1, ABL1, IKBKE, MAP4K1, HRAS, CUL9, GBP1, RUNX1, IKBKB, FYN, ZAP70, MAP4K2, TP53, NLRP3, MX1"], ["GO:0032559", "MF", "Adenylribonucleotide binding", "1.44E − 03", "6.51E − 03", "4.36E − 02", "6.57E − 01", "14", "JAK1, JAK2, IFIH1, ABL1, IKBKE, MAP4K1, CUL9, RUNX1, IKBKB, FYN, ZAP70, MAP4K2, TP53, NLRP3"]], "row_count": 31, "column_count": 9, "numeric_cells": 206, "header_rows": 1, "locator": "section[14]/table-wrap[1]#Tab4"}}, {"id": "asset:table:pmid:33251083:5", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:9ea3fe1ecbcc8d1365fe22b90c78b557792dba52572caca21621e8b502cab796", "bytes": 17310, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[14]/table-wrap[2]#Tab5", "version": null, "note": "The enriched GO terms of the down regulated differentially expressed genes", "structure": {"pmcid": "PMC7679428", "section_index": 6, "section_title": "Gene ontology (GO) enrichment analysis for DEGs", "row_count": 32, "column_count": 9}, "table": {"label": "Table 5", "caption": "The enriched GO terms of the down regulated differentially expressed genes", "rows": [["GO ID", "Category", "GO Name", "P Value", "FDR B&H", "FDR B&Y", "Bonferroni", "Gene Count", "Gene"], ["GO:0002682", "BP", "Regulation of immune system process", "1.87E − 103", "9.66E − 100", "8.82E − 99", "9.66E − 100", "153", "IL10, IL12A, IL12B, IL13, IRGM, MASP1, TRAF3, IL17A, CEBPB, CD244, HLA-B, HLA-C, IDO1, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, MAPKAPK2, HLA-DQB1, HLA-DRA, CTSC, HLA-DRB1, PECAM1, MBL2, TNFRSF14, GATA3, ETS1, PSMB10, CD55, PTPN22, CD46, BCL2, PTAFR, CD83, PTGER4, IL1RL2, CD209, PTK2, STAT5A, STAT6, TNFRSF4, CFD, PTPN6, SLAMF6, FCER1A, PIGR, FCGR2A, FCGR2B, CARD9, BTK, MIF, IL21, C1R, C1S, C4A, C4BPA, CCL7, CCR6, C6, C7, C8A, CCL19, C8B, CCL20, C9, CCL24, TAL1, XCL1, KIT, CX3CL1, KLRB1, CXCL12, VCAM1, SELE, GPI, RAG1, DPP4, ICOSLG, LILRA1, LILRA2, ZEB1, VTN, CLEC6A, ATG7, ICAM2, ICAM3, ICAM4, CXCL13, CASP3, AIRE, RELA, BTLA, RELB, GPR183, TLR9, LCK, CFI, CR2, IL23A, IFNA2, LGALS3, TFRC,IFNB1, IFNG, LIF, CD1A, CD3E, CSF1R, CSF2, CD8A, THY1, CD9, CSF3R, CD19, TIGIT, MS4A1, EBI3, CD22, IL20, CD80, CD86, ICAM5, TIRAP, CD34, CD40, IRAK4, CD44, CD48, TNFRSF13C, CD59, CD74, CD79A, CD79B, LTA, RORC, CTLA4, PAX5, HAMP, MAPK11, IL2, IL3, IL4, IL4R, IL5, CTSS, IL6, IL6R, IL7, IL27, MASP2, CXCR2"], ["GO:0019221", "BP", "Cytokine-mediated signaling pathway", "1.05E − 84", "1.35E − 81", "1.23E − 80", "5.40E − 81", "131", "IL10, IL10RA, IL12A, IL12B, IL13, IRGM, MASP1, TRAF3, IL17A, ILF3, CEBPB, CD244, HLA-B, AICDA, HLA-C, IDO1, TAGAP, HLA-DPA1, HLA-DPB1, HLA-DQA1, MAPKAPK2, HLA-DQB1, HLA-DRA, HLA-DRB1, MBL2, TNFRSF14, GATA3, PSMB10, CD55, PTPN22, CD46, BCL2, DEFB103B, PTAFR, PTGER4, IL1RL2, CCL26, CD209, STAT5A, BID, DEFB1, DEFB4A, CFD, PTPN6, SLAMF6, FCGR2B, CARD9, BTK, KLRF2, MIF, IL21, PLA2G2A, TOLLIP, C1R, C1S, C4A, C4BPA, CCL7, CCL11, CCL13, BATF3, CCL15, CCL16, C6, C7, CCL18, C8A, CCL19, C8B, CCL20, CCL22, C9, CCL24, CXCL11, XCL1, CX3CL1, NOS2, CXCL12, VCAM1, SELE, RAG2, LILRA2, CLEC6A, BCL2L11, ATG7, ITLN1, ICAM2, ICAM3, IRF8, CXCL13, CASP3, RELA, RELB, TLR9, PPBP, CFI, CR2, IL23A, IFNA2, EDNRB, LGALS3, IFNAR1, IFNB1, IFNG, CSF1R, CSF2, CD8A, CSF2RB, MS4A1, EGR1, SIGIRR, CD80, CD86, TIRAP, CD40, IRAK4, CD44, CD74, CD79B, LTA, HAMP, MAPK11, IL1RAP, IL2, IL4, IL4R, CTSS, IL6, IL6R, IL27, MASP2"], ["GO:0009607", "BP", "RESPONSE to biotic stimulus", "7.42E − 81", "7.65E − 78", "6.99E − 77", "3.83E − 77", "120", "IL10, IL10RA, IL12A, IL12B, IL13, IL13RA1, IRGM, IL16, TRAF3, TNFRSF9, IL17A, CEBPB, HLA-B, PDGFB, HLA-C, TNFSF12, SPP1, HLA-DPA1, HLA-DPB1, HLA-DQA1, MAPKAPK2, HLA-DQB1, HLA-DRA, HLA-DRB1, TNFRSF14, GATA3, ETS1, PSMB10, BCL2, PTAFR, IL1RL2, CCL26, IL17F,STAT5A, STAT6, TNFRSF4, PTPN6, IL22RA2, NFIL3, BTK, MIF, IL21, TOLLIP, CCL7, CCR6, CCL11, CCL13, CCR8, CCL15, MME, CCL16, CCL18, CCL19, CCL20, CCL22,CCL24, CXCL11, XCL1, KIT, CX3CL1, NOS2, CXCL12, VCAM1, IL19, SELE, SELPLG, CCR10, XCR1, TCF7, ZEB1, FN1, IRF8, CXCL13, CASP3, RELA, RELB, PPBP, IL23A, S1PR1, IFNA2, TFRC, IFNAR1, IFNB1, IFNG, LIF, CSF1R, CSF2, CSF2RB, CSF3R, EBI3, EGR1, SIGIRR, IL20, CD80, CD86, TIRAP, IL22, CD40, IRAK4, CD44, TNFRSF13C, CD74, LTA, RORC, HAMP, MAPK11, IL1RAP, IL2, IL3, IL4, IL4R, IL5, IL6, IL6R, IL7, IL26, IL27, CXCR1, IL9, CXCR2"], ["GO:0009607", "BP", "Response to biotic stimulus", "7.42E − 81", "7.65E − 78", "6.99E − 77", "3.83E − 77", "131", "IL10, IL10RA, IL12A, IL12B, IL13, IRGM, MASP1, TRAF3, IL17A, ILF3, CEBPB, CD244, HLA-B, AICDA, HLA-C, IDO1, TAGAP, HLA-DPA1, HLA-DPB1, HLA-DQA1, MAPKAPK2, HLA-DQB1, HLA-DRA, HLA-DRB1, MBL2, TNFRSF14, GATA3, PSMB10, CD55, PTPN22, CD46, BCL2, DEFB103B, PTAFR, PTGER4, IL1RL2, CCL26, CD209, STAT5A, BID, DEFB1, DEFB4A, CFD, PTPN6, SLAMF6, FCGR2B, CARD9, BTK, KLRF2, MIF, IL21, PLA2G2A, TOLLIP, C1R, C1S, C4A, C4BPA, CCL7, CCL11, CCL13, BATF3, CCL15, CCL16, C6, C7, CCL18, C8A, CCL19, C8B, CCL20, CCL22, C9, CCL24, CXCL11, XCL1, CX3CL1, NOS2, CXCL12, VCAM1, SELE, RAG2, LILRA2, CLEC6A, BCL2L11, ATG7, ITLN1, ICAM2, ICAM3, IRF8, CXCL13, CASP3, RELA, RELB, TLR9, PPBP, CFI, CR2, IL23A, IFNA2, EDNRB, LGALS3, IFNAR1, IFNB1, IFNG, CSF1R, CSF2, CD8A, CSF2RB, MS4A1, EGR1, SIGIRR, CD80, CD86, TIRAP, CD40, IRAK4, CD44, CD74, CD79B, LTA, HAMP, MAPK11, IL1RAP, IL2, IL4, IL4R, CTSS, IL6, IL6R, IL27, MASP2"], ["GO:0034097", "BP", "Response to cytokine", "3.04E − 80", "2.61E − 77", "2.39E − 76", "1.57E − 76", "120", "IL10, IL10RA, IL12A, IL12B, IL13, IL13RA1, IRGM, IL16, TRAF3, TNFRSF9, IL17A, CEBPB, HLA-B, PDGFB, HLA-C, TNFSF12, SPP1, HLA-DPA1, HLA-DPB1, HLA-DQA1, MAPKAPK2, HLA-DQB1, HLA-DRA, HLA-DRB1, TNFRSF14, GATA3, ETS1, PSMB10, BCL2, PTAFR, IL1RL2, CCL26, IL17F, STAT5A, STAT6, TNFRSF4, PTPN6, IL22RA2, NFIL3, BTK, MIF, IL21, TOLLIP, CCL7, CCR6, CCL11, CCL13, CCR8, CCL15, MME, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, KIT, CX3CL1, NOS2, CXCL12, VCAM1, IL19, SELE, SELPLG, CCR10, XCR1, TCF7, ZEB1, FN1, IRF8, CXCL13, CASP3, RELA, RELB, PPBP, IL23A, S1PR1, IFNA2, TFRC, IFNAR1, IFNB1, IFNG, LIF, CSF1R, CSF2, CSF2RB, CSF3R, EBI3, EGR1, SIGIRR, IL20, CD80, CD86, TIRAP, IL22, CD40, IRAK4, CD44, TNFRSF13C, CD74, LTA, RORC, HAMP, MAPK11, IL1RAP, IL2, IL3, IL4, IL4R, IL5, IL6, IL6R, IL7, IL26, IL27, CXCR1, IL9, CXCR2"], ["GO:0042110", "BP", "T cell activation", "8.30E − 63", "2.25E − 60", "2.06E − 59", "4.28E − 59", "77", "IL10, IL12A, IL12B, CEBPB, CD244, IDO1, HLA-DMA, HLA-DMB, HLA-DPA1, HLA-DPB1, HLA-DQA1, TNFRSF14, GATA3, PSMB10, CD55, PTPN22, CD46, BCL2, CD83, PTGER4, IL1RL2, CD209, STAT5A, STAT6, TNFRSF4, EOMES, PTPN6, SLAMF6, FCGR2B, IL21, CCR6, CCL19, CCL20, XCL1, KIT, CXCL12, VCAM1, RAG1, RAG2, DPP4, ICOSLG, TCF7, ZEB1, CASP3, AIRE, BTLA, RELB, GPR183, LCK, IL23A, IFNA2, LGALS3, TFRC, IFNAR1, IFNB1, IFNG, CD3E, CD8A, THY1, TIGIT, EBI3, EGR1, CD80, CD86, CD44, CD48, TNFRSF13C, CD74, RORC, CTLA4, IL2, IL4, IL4R, IL6, IL6R, IL7, IL27"], ["GO:0001816", "BP", "Cytokine production", "8.07E − 58", "1.81E − 55", "1.65E − 54", "4.16E − 54", "87", "IL10, IL12A, IL12B, IL13, TRAF3, TNFRSF9, IL17A, CEBPB, CD244, IDO1, HLA-DPA1, HLA-DPB1, MAPKAPK2, IL17B, MBP, TNFRSF14, GATA3, CD55, PTPN22, CD46, PTAFR, CD83, PTGER4, IL1RL2, IL17F, STAT5A, STAT6, TNFRSF4, EOMES, PTPN6, SLAMF6, FCER1A, FCGR2B, CARD9, BTK, KLRF2, MIF, IL21, CCL19, CCL20, XCL1, KIT, CX3CL1, NOS2, IL19, ICOSLG, LILRA2, CLEC6A, FN1, IRF8, AIRE, RELA, RELB, TLR9, IL23A, IFNA2, IFNAR1, IFNB1, IFNG, CD3E, CSF1R, CSF2, TIGIT, EBI3, EGR1,SIGIRR, CD80, CD86, TIRAP, CD34, CD40, IRAK4, TNFRSF13C, CD74,LTA, RORC, MAPK11, IL1RAP, IL2, IL4, IL4R, IL6, IL6R, IL7, IL26, IL27, IL9"], ["GO:0002694", "BP", "Regulation of leukocyte activation", "7.07E − 57", "1.52E − 54", "1.39E − 53", "3.65E − 53", "77", "IL10, IL12A, IL12B, IL13, CEBPB, CD244, IDO1, HLA-DMA, HLA-DMB, HLA-DPA1, HLA-DPB1, HLA-DQA1, CTSC, TNFRSF14, GATA3, CD55, PTPN22, CD46, BCL2, PTAFR, CD83, IL1RL2, CD209, STAT5A, STAT6, TNFRSF4, PTPN6, FCER1A, FCGR2B, BTK, MIF, IL21, CCR6, CCL19, CCL20, XCL1, CX3CL1, VCAM1, RAG1, DPP4, ICOSLG, ZEB1, CASP3, BTLA, GPR183, TLR9, LCK, IL23A, IFNA2, LGALS3, TFRC, IFNB1, IFNG, CD3E, THY1, CD19, TIGIT, EBI3, CD22, CD80, CD86, TIRAP, CD40, CD44, TNFRSF13C, CD74, RORC, CTLA4, HAMP, IL2, IL4, IL4R, IL5, IL6, IL6R, IL7, IL27"], ["GO:0006954", "BP", "Inflammatory response", "5.64E − 55", "1.12E − 52", "1.02E − 51", "2.91E − 51", "82", "IL10, IL12B, IL13, IRGM, IL17A, CEBPB, IDO1, SPP1, MAPKAPK2, CTSC, IL17B, MBL2, GATA3, ETS1, PTAFR, PLA2G2E, PTGER4, IL1RL2, CCL26, IL17F, STAT5A, TNFRSF4, IL22RA2, FCER1A, FCGR2B, BTK,MIF, IL21, PLA2G2A, TOLLIP, C4A, CCL7, CCR6,CCL11, CCL13, CCL15, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, KIT, CX3CL1, NOS2, VCAM1, SELE, XCR1, FN1, NT5E, CXCL13, RELA, RELB, TLR9, PPBP, IL23A, IFNA2, EDNRB, IFNG, CSF1R, SIGIRR, IL20, TIRAP, IL22, CD40, CD44, LTA, HAMP, IL1RAP, IL2, CDH5, IL4, IL4R, IL5, CTSS, IL6, IL6R, IL27, IL9, CXCR2"], ["GO:0007155", "BP", "Cell adhesion", "3.87E − 42", "3.50E − 40", "3.20E − 39", "2.00E − 38", "91", "IL10, IL12A, IL12B, CEBPB,CD244, IDO1, HLA-DMA, HLA-DMB, SPP1, HLA-DPA1, HLA-DPB1, HLA-DQA1, PECAM1, MBP, TNFRSF14, GATA3, ETS1, CD55, PTPN22, CD46, BCL2, PTAFR, CD83, ITGAE, PTGER4, IL1RL2, CD209, PTK2, STAT5A, PTPN6, FCGR2B, IL21, PLAU, CCL11, CCR8, CCL19, XCL1, KIT, MAP4K4, CX3CL1, CXCL12, VCAM1, SELE, SELPLG, RAG1, DPP4, ICOSLG, VTN, FN1, BCL2L11, NT5E, ICAM2, ICAM3, ICAM4, CXCL13, CASP3, RELA, BTLA, LCK, IL23A, S1PR1, IFNA2, LGALS3, TFRC, IFNB1, IFNG, TGFBI, ARHGDIB, CD3E, THY1, CD9, CSF3R, TIGIT, EBI3, CD22, CD80, CD86, ICAM5, CD34, CD44, TNFRSF13C, CD74, CTLA4,IL1RAP, IL2, CDH5, IL4, IL4R, IL6, IL6R, IL7"], ["GO:0009986", "CC", "Cell surface", "8.40E − 48", "1.04E − 45", "6.72E − 45", "3.09E − 45", "83", "IL12A, IL12B, IL13, IL13RA1, TNFRSF9, IL17A, CD244, HLA-B, PDGFB, HLA-C, HLA-DMA, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DRA, HLA-DRB1, PECAM1, MBL2, MBP, TNFRSF14, CD55, CD46, TNFRSF10C, CD83, ITGAE, CD209, TNFRSF4, FCER1A, FCGR2B, FCGRT, MIF, PLAU, CCR6, CCR8, MME, KIT, CX3CL1, CXCL12, VCAM1, CCR10, DPP4, ICOSLG, XCR1, NT5E, BTLA, CR2, S1PR1, LGALS3, TFRC, IFNG, TGFBR1, CD1A, CD3E, CSF1R, CD8A, THY1, CD9, CSF3R, CD19, TIGIT, MS4A1, EBI3, CD22, CD80, CD86, CD34, CD40, CD44, CD48, TNFRSF13C, CD59, CD74, CD79A, CD79B, RORC, CTLA4, CDH5, IL4, CTSS, IL6, IL6R, CXCR1, CXCR2"], ["GO:0097478", "CC", "Leaflet of membrane bilayer", "8.80E − 48", "1.04E − 45", "6.72E − 45", "3.24E − 45", "70", "IL12B, IL13, IL13RA1, TRAF3, TNFRSF9, IL17A, CD244, HLA-B, HLA-C, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, PECAM1, TNFRSF14, PTPN22, CD83, ITGAE, CD209, TNFRSF4, FCER1A, FCGR2B, FCGRT, CCR6, CCR8, KIT, CXCL12, VCAM1, CCR10, ICOSLG, XCR1, BTLA, LCK, CR2, S1PR1, LGALS3, TFRC, IFNG, CD1A, CD3E, BCAP31, CD8A, THY1, CD9, CSF3R, CD19, MS4A1, EBI3, CD22, CD80, CD86, CD34,CD40, CD44, CD48, TNFRSF13C, CD59,CD74, CD79A, CD79B, RORC, CTLA4, CDH5, IL4, IL6, IL6R, CXCR1, CXCR2"], ["GO:0031226", "CC", "Intrinsic component of plasma membrane", "4.10E − 24", "3.01E − 22", "1.96E − 21", "1.51E − 21", "75", "IL13RA1, TRAF3, TNFRSF9,TNFSF12, HLA-DPA1, HLA-DQA1, HLA-DRA, CD46,PTAFR, CD83, ITGAE, IL1RL2, TNFRSF4, CD82, SLAMF6,FCAR, FCER1A, PIGR, FCGR2B, KLRF2, TOLLIP, CCR6, CCR8, MME, C6, C7, C8A, C8B, C9, KIT, VCAM1, SELE, SELPLG, CCR10, ICOSLG, XCR1, LILRA2, ICAM2, ICAM3, ICAM4, BTLA, GPR183, S1PR1, SLC2A1, EDNRB, TFRC, IFNAR1, TGFBR1,CD1A, CD3E, BCAP31, CSF1R, CD8A, THY1, CSF2RB, CD9, CSF3R, CD19, MS4A1, EBI3, CD22, ICAM5, CD34, CD40, CD44, CD48, CD59, CD74, CD79B, CTLA4, IL1RAP, IL4R, IL6, IL6R, CXCR2"], ["GO:0098589", "CC", "Membrane region", "7.35E − 11", "1.93E − 09", "1.25E − 08", "2.70E − 08", "24", "PECAM1, CD55, CD46, STAT6, FCER1A, BTK, MME, SELE, SELPLG, DPP4, ITLN1, CASP3, LCK, S1PR1, SLC2A1, EDNRB, TGFBR1, CD1A, CD8A, THY1, CD19, MS4A1, CD48, CD79A"], ["GO:0043235", "CC", "Receptor complex", "3.10E − 10", "6.71E − 09", "4.35E − 08", "1.14E − 07", "26", "IL12B, IL13RA1, TRAF3, ITGAE, PTPN6, PIGR, TOLLIP, KIT, ITLN1, CR2, TFRC, TGFBR1, CD3E, CSF1R, CD8A, CSF2RB, CSF3R, EBI3, CD40, CD44, CD74, CD79A, CD79B, IL4R, IL6, IL6R"], ["GO:0030141", "CC", "Secretory granule", "3.67E − 07", "5.20E − 06", "3.37E − 05", "1.35E − 04", "29", "PDGFB, CTSC, PECAM1, CD55, CD46, PTAFR, CFD, PTPN6, FCAR, PIGR, FCGR2A, MIF, PLA2G2A, TOLLIP, PLAU, MME, KIT, GPI, LILRA3, FN1, ATG7, PPBP, LGALS3, CD9, CD44, CD59, CTSS, CXCR1, CXCR2"], ["GO:0005764", "CC", "Lysosome", "1.31E − 06", "1.49E − 05", "9.69E − 05", "4.81E − 04", "25", "IL13, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, CTSC, HLA-DRB1, FCER1A, PIGR, BTK, TOLLIP,KIT, DPP4, TLR9, IFNAR1, CD34, CD74, IL4, IL4R, CTSS, CXCR2"], ["GO:0005794", "CC", "Golgi apparatus", "4.18E − 03", "2.00E − 02", "1.30E − 01", "1.00E + 00", "31", "IRGM, HLA-B, PDGFB, HLA-C,SPP1, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, CTSC, HLA-DRB1, CD55, CD46, DEFB103B, DEFB1,DEFB4A, MME, VCAM1, DPP4, VTN, TLR9, SLC2A1, TGFBI, BCAP31, CD44, CD59, CD74, CD79B, B3GAT1, CTLA4"], ["GO:0048471", "CC", "Perinuclear region of cytoplasm", "2.87E − 02", "8.46E − 02", "5.49E − 01", "1.00E + 00", "16", "TNFSF12, SPP1, PTPN22, BCL2, BTK, PLA2G2A, TOLLIP, CX3CL1, NOS2, SELE, ATG7,TFRC, TRAF4, BCAP31, CD34, CTLA4"], ["GO:0044297", "CC", "Cell body", "9.03E − 02", "2.08E − 01", "1.00E + 00", "1.00E + 00", "14", "PDGFB, MBP, PTGER4, FCGR2B, C4A, MME, CX3CL1, CASP3,IFNG, CD3E, THY1, CD22, CD40, IL6R"], ["GO:0030054", "CC", "Cell junction", "9.70E − 02", "2.20E − 01", "1.00E + 00", "1.00E + 00", "21", "PECAM1, CD46, PTK2, PTPN6, C4A, PLAU, MME, KIT, MAP4K4, DPP4, LCK, SLC2A1, TGFBR1, TRAF4, CD3E, THY1, CD9, CD44,CD59, HAMP, CDH5"], ["GO:0005126", "MF", "Cytokine receptor binding", "8.37E − 54", "6.01E − 51", "4.30E − 50", "6.01E − 51", "59", "IL10, IL12A, IL12B, IL13, TRAF3, TNFSF12, GATA3, DEFB103B, CCL26, IL17F, BID, DEFB1, DEFB4A, MIF, IL21, TOLLIP, CCL7, CCL11, CCL13, CCL15, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, CX3CL1, CXCL12, CXCL13, CASP3, TLR9, PPBP, IL23A, IFNA2, IFNB1, IFNG, TGFBR1, LIF, TRAF4, CSF2, EBI3, IL20, IL22,IRAK4, CD44, LTA, IL1RAP, IL2,IL3, CDH5,IL4, IL5, IL6, IL6R, IL7, IL27, IL9"], ["GO:0005102", "MF", "Signaling receptor binding", "3.78E − 49", "9.05E − 47", "6.48E − 46", "2.72E − 46", "108", "IL10, IL12A, IL12B, IL13, IL16, TRAF3, IL17A, CEBPB, CD244, HLA-B, PDGFB, HLA-C, TNFSF12, HLA-DOB, SPP1, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, IL17B, MBL2, GATA3, DEFB103B, CCL26, IL17F, PTK2, BID, DEFB1, DEFB4A, PTPN6, PIGR, MIF, IL21, TOLLIP, CCL7, CCL11, CCL13, CCL15, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, CX3CL1, CXCL12, VCAM1, IL19, SELPLG, GPI, DPP4, ICOSLG, VTN, FN1, ATG7, ICAM2, ICAM3, ICAM4, CXCL13, CASP3, TLR9, LCK, PPBP, IL23A, S1PR1, IFNA2, EDNRB, LGALS3, IFNB1, IFNG, TGFBI, TGFBR1, LIF, TRAF4, CD3E,BCAP31, CSF2, CD8A, THY1, CD9, TIGIT, MS4A1, EBI3, CD22, IL20, CD86, ICAM5, TIRAP, IL22, IRAK4, CD44, CD74, LTA, HAMP, IL1RAP, IL2, IL3, CDH5, IL4, IL5, IL6, IL6R, IL7, IL26, IL27, IL9"], ["GO:0030545", "MF", "Chemokine receptor binding", "2.63E − 22", "2.36E − 20", "1.69E − 19", "1.89E − 19", "20", "DEFB103B, CCL26, DEFB1, DEFB4A, CCL7, CCL11,CCL13, CCL15, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, CX3CL1, CXCL12, CXCL13, PPBP"], ["GO:0098772", "MF", "Molecular function regulator", "1.42E − 18", "6.80E − 17", "4.86E − 16", "1.02E − 15", "71", "IL10, IL12A, IL12B, IL13, IRGM, IL16, IL17A, PDGFB, TNFSF12, SPP1, TAGAP, CTSC, IL17B, CD46, BCL2, DEFB103B, CCL26, IL17F, EOMES, DEFB4A, MIF, IL21, C4A, CCL7, CCL11, CCL13, CCL15, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, CX3CL1, NOS2, CXCL12, IL19, GPI, FN1, CXCL13, CASP3, SKI, PPBP, IL23A, IFNA2, LGALS3, IFNB1, IFNG, LIF, ARHGDIB, TRAF4, CSF2, THY1, EBI3, IL20, TIRAP, IL22, LTA, HAMP, IL2, IL3, IL4, IL5, IL6, IL6R, IL7, IL26,IL27, IL9"], ["GO:0004888", "MF", "Transmembranesignaling receptor activity", "2.09E − 12", "8.81E − 11", "6.31E − 10", "1.50E − 09", "50", "IL10RA, IL12B, IL13RA1, HLA-DOB, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, TNFRSF14, TNFRSF10C, PTAFR, PTGER4, IL1RL2, TNFRSF4, PTPN6, IL22RA2, FCER1A, PIGR, FCGR2B, CCR6, CCR8, KIT, KLRB1, LILRB5, SELE, CCR10, XCR1, LILRA1, GPR183, TLR9, CR2, S1PR1, EDNRB, IFNAR1, IFNG, TGFBR1, CD3E, CSF1R, CSF2RB, CSF3R, EBI3, CD44, CD74, CD79A, CD79B, IL1RAP, IL4R, IL6R, CXCR1, CXCR2"], ["GO:0001664", "MF", "G protein-coupled receptor binding", "3.80E − 12", "1.52E − 10", "1.08E − 09", "2.73E − 09", "23", "DEFB103B, CCL26, DEFB1, DEFB4A, CCL7, CCL11, CCL13, CCL15, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, CX3CL1, CXCL12, CXCL13, PPBP, S1PR1, EDNRB, IL2"], ["GO:0044877", "MF", "Protein-containing complex binding", "1.24E − 11", "4.46E − 10", "3.19E − 09", "8.92E − 09", "48", "PDGFB, HLA-DMA, HLA-DMB, HLA-DOB, SPP1, HLA-DRA, HLA-DRB1, PTK2, FCAR, FCER1A, PIGR, FCGR2A, FCGR2B, FCGRT, MIF, C8A, C8B, CX3CL1, CXCL12, VCAM1, DPP4, LILRA2, VTN, FN1, BCL2L11, ICAM2, ICAM3, ICAM4, CASP3, RELA, LCK, IFNA2, LGALS3, IFNB1, TGFBI, TGFBR1, CD3E, BCAP31, CD8A, THY1, CD9, MS4A1, CD22, ICAM5, CD44, CD74, CDH5, CTSS"], ["GO:0042802", "MF", "IDENTICAL protein binding", "1.81E − 07", "3.93E − 06", "2.81E − 05", "1.30E − 04", "51", "IL12B, MASP1, CEBPB, AICDA, PDGFB, CTSC, PECAM1, ETS1, BCL2, IL17F, PTK2, STAT6, DEFB1, CARD9, BTK, KLRF2, MIF, C1S, MME, XCL1, KIT, NOS2, RAG1, DPP4, ICOSLG, TCF4, IKZF2, VTN, FN1, ATG7, ITLN1, AIRE, RELA, RELB, TLR9, LCK, CR2, SLC2A1, LGALS3, TFRC, TRAF4, CD3E, CSF1R, CD8A, TIGIT, TIRAP, CD74, CD79A, CD79B, CDH5, IL6R"], ["GO:0046983", "MF", "Protein dimerization activity", "6.79E − 07", "1.19E − 05", "8.51E − 05", "4.88E − 04", "42", "IL10, IL12A, IL12B, MASP1, CEBPB, PDGFB, HLA-DQA1, PECAM1, GATA3, BCL2, IL17F, BID, CARD9, KLRF2, CCL11, MME, TAL1, XCL1, KIT, NOS2, RAG1, DPP4, TCF4, IKZF2, BCL2L11, ATG7, CXCL13, RELA, TLR9, CR2, LGALS3, TFRC, TGFBR1, TRAF4, CD3E, CSF1R, CD8A, TIRAP, CD79A, CD79B, CDH5, IL6R"], ["GO:0016301", "MF", "Kinase activity", "1.16E − 05", "1.54E − 04", "1.10E − 03", "8.29E − 03", "40", "IL12B, IRGM, PDGFB, MAPKAPK2, PTPN22, PTK2, TNFRSF4, PTPN6, FCER1A, BTK, MIF, CCL19, TAL1, KIT, MAP4K4, NOS2, GPI, DUSP4, CASP3, TLR9, LCK, IL23A, IFNG, TGFBR1, TRAF4, CSF1R, THY1, CD19, EGR1, TIRAP, CD40, IRAK4, CD44, CD74, MAPK11, IL2, IL3, IL4, IL6, IL6R"]], "row_count": 32, "column_count": 9, "numeric_cells": 217, "header_rows": 1, "locator": "section[14]/table-wrap[2]#Tab5"}}, {"id": "asset:table:pmid:33251083:6", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:72eaeba363b965fe7e952d91d5d134b882754beaa91740a8a3be9d2804db13fb", "bytes": 16979, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[15]/table-wrap[1]#Tab6", "version": null, "note": "Topology table for up and down regulated genes", "structure": {"pmcid": "PMC7679428", "section_index": 7, "section_title": "PPI network construction and module analysis", "row_count": 277, "column_count": 7}, "table": {"label": "Table 6", "caption": "Topology table for up and down regulated genes", "rows": [["Regulation", "Node", "Degree", "Betweenness", "Stress", "Closeness", "Clustering Coefficient"], ["Up", "TP53", "682", "0.308256", "69419762", "0.44613", "0.001042"], ["Up", "HRAS", "543", "0.243425", "36147274", "0.454702", "0.003568"], ["Up", "CTNNB1", "454", "0.17049", "60805652", "0.403018", "0.002042"], ["Up", "FYN", "396", "0.117564", "12570856", "0.436236", "0.010907"], ["Up", "ABL1", "362", "0.118179", "7631538", "0.470883", "0.015228"], ["Up", "JAK2", "258", "0.054758", "7164820", "0.434802", "0.021748"], ["Up", "STAT3", "253", "0.05294", "16470742", "0.398767", "0.02108"], ["Up", "JAK1", "223", "0.032981", "6336566", "0.40235", "0.019876"], ["Up", "TRAF6", "216", "0.074546", "12176648", "0.395301", "0.010207"], ["Up", "STAT1", "213", "0.045072", "12845532", "0.387307", "0.023031"], ["Up", "TRAF2", "171", "0.047572", "11238720", "0.357837", "0.007981"], ["Up", "ZAP70", "153", "0.018814", "3346658", "0.375226", "0.028294"], ["Up", "IKBKB", "140", "0.040639", "5153454", "0.403521", "0.017575"], ["Up", "MX1", "125", "0.057134", "6475242", "0.352549", "0.002194"], ["Up", "STAT5B", "118", "0.012758", "2934924", "0.377415", "0.057801"], ["Up", "ZBTB16", "105", "0.029011", "4339392", "0.371064", "0.00696"], ["Up", "GP1BB", "104", "0.024662", "2308816", "0.350596", "0.009335"], ["Up", "RUNX1", "95", "0.021204", "3579930", "0.370309", "0.010526"], ["Up", "C1QBP", "89", "0.043687", "7011558", "0.334675", "0"], ["Up", "TLR2", "85", "0.019615", "2401022", "0.374839", "0.034734"], ["Up", "SOCS1", "85", "0.019595", "1846156", "0.398713", "0.072829"], ["Up", "SMAD5", "82", "0.024208", "4462604", "0.336687", "0.003011"], ["Up", "ITGB2", "72", "0.025976", "3349086", "0.351061", "0.008607"], ["Up", "IKZF1", "72", "0.011714", "1722502", "0.373157", "0.034038"], ["Up", "CCND3", "71", "0.025956", "2361424", "0.357661", "0.008048"], ["Up", "ATG5", "60", "0.020131", "2294688", "0.333219", "0.00678"], ["Up", "IFIH1", "59", "0.023459", "2059722", "0.333945", "0.001753"], ["Up", "STAT4", "58", "0.002561", "797810", "0.366902", "0.082275"], ["Up", "PSMB9", "55", "0.0248", "2740768", "0.310739", "0"], ["Up", "IKZF3", "47", "0.005026", "756292", "0.361346", "0.053654"], ["Up", "GFI1", "46", "0.007563", "811180", "0.357266", "0.013527"], ["Up", "IRF7", "44", "0.010411", "1198488", "0.338804", "0.008457"], ["Up", "MAP4K1", "44", "0.006432", "851692", "0.348957", "0.046512"], ["Up", "CD247", "43", "0.00724", "710792", "0.349292", "0.058693"], ["Up", "LCP2", "41", "0.003353", "442356", "0.338331", "0.07439"], ["Up", "CCR5", "39", "0.010719", "942222", "0.343359", "0.043185"], ["Up", 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540, "header_rows": 1, "locator": "section[16]/table-wrap[1]#Tab7"}}, {"id": "asset:table:pmid:33251083:8", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:fc7eead614710882690059e1d793e3977d8f342b2ee037055408615b89dca16d", "bytes": 4208, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[17]/table-wrap[1]#Tab8", "version": null, "note": "TF—target gene interaction table", "structure": {"pmcid": "PMC7679428", "section_index": 9, "section_title": "Construction of target gene–TF regulatory network", "row_count": 75, "column_count": 8}, "table": {"label": "Table 8", "caption": "TF—target gene interaction table", "rows": [["Regulation", "TF", "Degree", "Target Gene", "Regulation", "TF", "Degree", "Target Gene"], ["Up", "FOXC1", "46", "JAK1", "Down", "FOXC1", "127", "KLRF2"], ["Up", "GATA2", "31", "TRAF6", "Down", "GATA2", "102", "CD1A"], ["Up", "YY1", "25", "CLEC7A", "Down", "YY1", "75", "TNFRSF4"], ["Up", "CREB1", "22", "STAT1", "Down", "FOXL1", "63", "MME"], ["Up", "TFAP2A", "21", "IKZF1", "Down", "NFKB1", "61", "CXCL12"], ["Up", "PPARG", "20", "IRF7", "Down", "USF2", "48", "DEFB1"], ["Up", "NFKB1", "20", "TRAF2", "Down", "SRF", "48", "STAT5A"], ["Up", "E2F1", "19", "PSMB9", "Down", "CREB1", "46", "TNFRSF10C"], ["Up", "RELA", "18", "IFI35", "Down", "TP53", "45", "C1S"], ["Up", "USF2", "17", "LTB4R", "Down", "STAT3", "45", "IL26"], ["Up", "SREBF1", "16", "CCND3", "Down", "PPARG", "43", "ICAM4"], ["Up", "HINFP", "15", "GP1BB", "Down", "JUN", "42", "FCGRT"], ["Up", "JUN", "15", "TLR2", "Down", "E2F1", "42", "GATA3"], ["Up", "FOXL1", "12", "LCP2", "Down", "HINFP", "40", "BCL2L11"], ["Up", "BRCA1", "11", "CD99", "Down", "TFAP2A", "38", "EOMES"], ["Up", "NFIC", "11", "FYN", "Down", "NFIC", "38", "IFNA2"], ["Up", "SRF", "11", "IL18RAP", "Down", "MEF2A", "31", "CTSS"], ["Up", "GATA3", "9", "CX3CR1", "Down", "NFYA", "29", "GPI"], ["Up", "PRDM1", "9", "GNLY", "Down", "TEAD1", "28", "LTA"], ["Up", "POU2F2", "9", "SLAMF7", "Down", "HOXA5", "28", "PPBP"], ["Up", "USF1", "8", "ATG5", "Down", "MAX", "27", "IL12B"], ["Up", "FOS", "8", "CCL5", "Down", "SREBF2", "26", "CD80"], ["Up", "TEAD1", "8", "CCR1", "Down", "SREBF1", "26", "DEFB4A"], ["Up", "TFAP2C", "8", "CEACAM1", "Down", "JUND", "26", "HLA-DPB1"], ["Up", "ELK4", "8", "GBP1", "Down", "TFAP2C", "26", "HLA-DQA1"], ["Up", "HOXA5", "8", "GZMB", "Down", "RUNX2", "25", "C1R"], ["Up", "E2F6", "8", "HRAS", "Down", "ARID3A", "24", "SKI"], ["Up", "HNF4A", "8", "IFNAR2", "Down", "HNF4A", "23", "CR2"], ["Up", "RUNX2", "8", "KLRK1", "Down", "ZNF354C", "22", "C8A"], ["Up", "NFYA", "7", "ATG10", "Down", "NR3C1", "22", "FCGR2B"], ["Up", "SREBF2", "7", "C1QBP", "Down", "IRF2", "22", "XCR1"], ["Up", "MAX", "7", "CCRL2", "Down", "PRDM1", "21", "IL13"], ["Up", "CEBPB", "7", "CD247", "Down", "FOS", "20", "CCL15"], ["Up", "PRRX2", "7", "CTNNB1", "Down", "USF1", "20", "IRAK4"], ["Up", "ZNF354C", "7", "GFI1", "Down", "FOXA1", "19", "ITLN1"], ["Up", "MEF2A", "7", "IL18R1", "Down", "PRRX2", "19", "TLR9"], ["Up", "ARID3A", "6", "ABL1", "Down", "STAT1", "18", "LCK"], ["Up", "ESR1", "6", "C2", "Down", "SP1", "16", "CD82"], ["Up", "PDX1", "6", "HLA-A", "Down", "ELK4", "16", "PAX5"], ["Up", "NR3C1", "6", "ITGAL", "Down", "NKX3-2", "16", "PLA2G2E"], ["Up", "KLF5", "6", "ITGB2", "Down", "KLF5", "15", "ICOSLG"], ["Up", "ELK1", "6", "JAK2", "Down", "ELK1", "15", "IDO1"], ["Up", "SP1", "6", "MAP4K2", "Down", "BRCA1", "15", "LGALS3"], ["Up", "EGR1", "6", "MX1", "Down", "ESR1", "15", "MASP2"], ["Up", "EN1", "6", "SMAD5", "Down", "TP63", "12", "CD19"], ["Up", "IRF2", "5", "RUNX1", "Down", "PAX2", "12", "CD48"], ["Up", "PAX2", "5", "STAT5B", "Down", "NR2F1", "12", "CEBPB"], ["Up", "NR2F1", "4", "CUL9", "Down", "E2F6", "11", "CD8A"], ["Up", "FOXF2", "4", "IKBKE", "Down", "EN1", "11", "IL22"], ["Up", "TP63", "4", "IKZF3", "Down", "SPIB", "11", "PTAFR"], ["Up", "FOXA1", "4", "IL2RG", "Down", "FOXF2", "10", "SELE"], ["Up", "NRF1", "4", "MAP4K1", "Down", "SOX10", "9", "POU2F2"], ["Up", "JUND", "4", "NLRP3", "Down", "SRY", "8", "EDNRB"], ["Up", "SPIB", "4", "ZBTB16", "Down", "NRF1", "8", "IFNAR1"], ["Up", "REL", "3", "IKZF3", "Down", "SOX17", "7", "TNFRSF14"], ["Up", "NKX3-1", "3", "IRF5", "Down", "SOX5", "6", "BTK"], ["Up", "SOX5", "3", "KLRD1", "Down", "NKX2-5", "6", "PIGR"], ["Up", "SOX10", "3", "STAT3", "Down", "ELF5", "5", "BATF3"], ["Up", "MYB", "3", "JAK2", "Down", "NFATC2", "5", "IL4"], ["Up", "SRY", "2", "KLRK1", "Down", "PDX1", "5", "ITGAE"], ["Up", "ELF5", "2", "TLR2", "Down", "NFYB", "3", "PTPN6"], ["Up", "NFIL3", "1", "CX3CR1", "Down", "ZFX", "3", "THY1"], ["Up", "NR4A2", "1", "C2", "Down", "NR4A2", "2", "CSF2"], ["Up", "FEV", "1", "ATG5", "Down", "FEV", "2", "IL23A"], ["Up", "FOXI1", "1", "CCL5", "Down", "MYB", "2", "MIF"], ["Up", "NKX3-2", "1", "GZMB", "Down", "HNF1B", "2", "SPP1"], ["Up", "E2F4", "1", "IKZF1", "Down", "REL", "2", "STAT6"], ["Up", "TFCP2L1", "1", "LCP2", "Down", "ESR2", "1", "CCL22"], ["Up", "NR2E3", "1", "HLA-A", "Down", "FOXI1", "1", "CD209"], ["Up", "GATA1", "1", "HLA-A", "Down", "FOXD1", "1", "HLA-DOB"], ["Up", "HNF1B", "1", "IL18R1", "Down", "ESRRB", "1", "ICAM2"], ["Up", "SOX17", "1", "LILRA6", "Down", "NR2E3", "1", "IL2"], ["", "", "", "", "Down", "E2F4", "1", "S1PR1"], ["", "", "", "", "Down", "GATA1", "1", "PDGFB"]], "row_count": 75, "column_count": 8, "numeric_cells": 183, "header_rows": 1, "locator": "section[17]/table-wrap[1]#Tab8"}}, {"id": "asset:table:pmid:33251083:9", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:ab2eb6a7044b00eb51c3c4e6fc432d9d6c9edd8c43fbcf05a2e22a783d99f064", "bytes": 32962, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[12]/table-wrap[1]#Tab1", "version": null, "note": "The statistical metrics for key differentially expressed genes (DEGs)", "structure": {"pmcid": "PMC7679428", "section_index": 12, "section_title": "Identification of DEGs", "row_count": 325, "column_count": 7}, "table": {"label": "Table 1", "caption": "The statistical metrics for key differentially expressed genes (DEGs)", "rows": [["Gene Symbol", "logFC", "pValue", "adj.P.Val", "t value", "Regulation", "Gene Name"], ["JAK1", "0.641818", "1.84E − 11", "1.84E − 11", "9.973193", "Up", "Janus kinase 1"], ["ZAP70", "0.810545", "2.91E − 10", "2.91E − 10", "8.897328", "Up", "Zeta chain of T cell receptor associated protein kinase 70"], ["CCR5", "1.239182", "3.04E − 10", "3.04E − 10", "8.880753", "Up", "C–C motif chemokine receptor 5 (gene/pseudogene)"], ["CTNNB1", "0.633545", "4.11E − 10", "4.11E − 10", "8.766907", "Up", "Catenin beta 1"], ["TRAF6", "0.644773", "7.11E − 10", "7.11E − 10", "8.561082", "Up", "TNF receptor associated factor 6"], ["FYN", "0.536182", "1.96E − 08", "1.96E − 08", "7.357891", "Up", "FYN proto-oncogene, Src family tyrosine kinase"], ["HRAS", "0.668773", "2.14E − 08", "2.14E − 08", "7.325507", "Up", "HRas proto-oncogene, GTPase"], ["ITGB2", "0.805182", "2.8E − 06", "2.8E − 06", "5.644273", "Up", "Integrin subunit beta 2"], ["ZBTB16", "1.099955", "3.88E − 06", "3.88E − 06", "5.53388", "Up", "Zinc finger and BTB domain containing 16"], ["ABL1", "0.468091", "4.46E − 06", "4.46E − 06", "5.486138", "Up", "ABL proto-oncogene 1, non-receptor tyrosine kinase"], ["CX3CR1", "0.834227", "6.3E − 06", "6.3E − 06", "5.369313", "Up", "C-X3-C motif chemokine receptor 1"], ["PDCD1", "0.880955", "7.79E − 06", "7.79E − 06", "5.297093", "Up", "Programmed cell death 1"], ["IRF5", "0.884364", "1.56E − 05", "1.56E − 05", "5.062275", "Up", "Interferon regulatory factor 5"], ["IL2RG", "0.590818", "1.7E − 05", "1.7E − 05", "5.032467", "Up", "Interleukin 2 receptor subunit gamma"], ["IKZF3", "0.467273", "1.78E − 0E − 05", "1.78E − 05", "5.016592", "Up", "IKAROS family zinc finger 3"], ["CCR1", "1.613727", "2.3E − 05", "2.3E − 05", "4.929543", "Up", "C–C motif chemokine receptor 1"], ["CD99", "0.398773", "4.76E − 05", "4.76E − 05", "4.681138", "Up", "CD99 molecule (Xg blood group)"], ["SMAD5", "0.349818", "5.02E − 05", "5.02E − 05", "4.662446", "Up", "SMAD family member 5"], ["CD247", "0.51", "5.34E − 05", "5.34E − 05", "4.641555", "Up", "CD247 molecule"], ["TP53", "0.372273", "5.85E − 05", "5.85E − 05", "4.609909", "Up", "Tumor protein p53"], ["LAG3", "0.988591", "6.64E − 05", "6.64E − 05", "4.566916", "Up", "Lymphocyte activating 3"], ["LCP2", "0.432682", "6.74E − 05", "6.74E − 05", "4.561553", "Up", "Lymphocyte cytosolic protein 2"], ["SLAMF7", "0.577409", "8.58E − 05", "8.58E − 05", "4.478485", "Up", "SLAM family member 7"], ["TMEM173", "0.377318", "0.000103", "0.000103", "4.416144", "Up", "Transmembrane protein 173"], ["CUL9", "0.4155", "0.000119", "0.000119", "4.366647", "Up", "Cullin 9"], ["C2", "1.280182", "0.000153", "0.000153", "4.279415", "Up", "Complement C2"], ["GNLY", "1.067364", "0.000167", "0.000167", "4.248083", "Up", "Granulysin"], ["ATG10", "0.490955", "0.000234", "0.000234", "4.130655", "Up", "Autophagy related 10"], ["IKZF1", "0.321682", "0.000285", "0.000285", "4.061503", "Up", "IKAROS family zinc finger 1"], ["KIR_Activating_Subgroup_2", "1.279318", "0.00043", "0.00043", "3.915229", "Up", "Killer-cell immunoglobulin-like receptorSubgroup 2"], ["ITGAL", "0.370273", "0.000461", "0.000461", "3.890576", "Up", "Integrin subunit alpha L"], ["SERPING1", "1.992773", "0.00057", "0.00057", "3.815201", "Up", "Serpin family G member 1"], ["STAT1", "1.066864", "0.000762", "0.000762", "3.711251", "Up", "signal transducer and activator of transcription 1"], ["CCRL2", "0.621773", "0.000844", "0.000844", "3.674266", "Up", "C–C motif chemokine receptor like 2"], ["RUNX1", "0.392409", "0.001035", "0.001035", "3.600334", "Up", "RUNX family transcription factor 1"], ["KIR_Activating_Subgroup_1", "1.243455", "0.001444", "0.001444", "3.478418", "Up", "Killer-cell immunoglobulin-like receptor Subgroup 1"], ["IFIH1", "1.189", "0.001492", "0.001492", "3.466339", "Up", "Interferon induced with helicase C domain 1"], ["GP1BB", "1.252364", "0.001517", "0.001517", "3.460324", "Up", "Glycoprotein Ib platelet subunit beta"], ["TBX21", "0.557591", "0.001716", "0.001716", "3.414736", "Up", "T-box transcription factor 21"], ["BST2", "0.825727", "0.00183", "0.00183", "3.390875", "Up", "Bone marrow stromal cell antigen 2"], ["JAK2", "0.436727", "0.001927", "0.001927", "3.371677", "Up", "Janus kinase 2"], ["PSMB9", "0.490864", "0.001928", "0.001928", "3.371431", "Up", "Proteasome 20S subunit beta 9"], ["XBP1", "0.485455", "0.002051", "0.002051", "3.348399", "Up", "X-box binding protein 1"], ["GBP1", "0.999545", "0.003627", "0.003627", "3.133218", "Up", "Guanylate binding protein 1"], ["STAT4", "0.295591", "0.003667", "0.003667", "3.129061", "Up", "Signal transducer and activator of transcription 4"], ["MAP4K1", "0.2385", "0.003959", "0.003959", "3.099644", "Up", "Mitogen-activated protein kinase kinasekinasekinase 1"], ["CCND3", "0.326591", "0.004076", "0.004076", "3.08846", "Up", "cyclin D3"], ["LILRA6", "0.817091", "0.004839", "0.004839", "3.022071", "Up", "Leukocyte immunoglobulin like receptor A6"], ["GFI1", "0.495591", "0.005741", "0.005741", "2.955427", "Up", "Growth factor independent 1 transcriptional repressor"], ["HLA-A", "0.385909", "0.005824", "0.005824", "2.949825", "Up", "Major histocompatibility complex, class I, A"], ["IL18RAP", "0.982227", "0.006135", "0.006135", "2.929331", "Up", "Interleukin 18 receptor accessory protein"], ["C1QBP", "0.264182", "0.006145", "0.006145", "2.928686", "Up", "Complement C1q binding protein"], ["CCL5", "0.3105", "0.006563", "0.006563", "2.902767", "Up", "C–C motif chemokine ligand 5"], ["SOCS1", "0.704318", "0.007115", "0.007115", "2.870801", "Up", "Suppressor of cytokine signaling 1"], ["STAT3", "0.370545", "0.010179", "0.010179", "2.72698", "Up", "Signal transducer and activator of transcription 3"], ["CEACAM1", "0.784909", "0.011682", "0.011682", "2.670737", "Up", "CEA cell adhesion molecule 1"], ["TLR2", "0.589773", "0.013287", "0.013287", "2.617647", "Up", "toll like receptor 2"], ["KLRK1", "0.358136", "0.014239", "0.014239", "2.588898", "Up", "killer cell lectin like receptor K1"], ["MAP4K2", "0.221227", "0.018828", "0.018828", "2.471244", "Up", "Mitogen-activated protein kinase kinasekinasekinase 2"], ["KLRC1", "0.7945", "0.019896", "0.019896", "2.4477", "Up", "Killer cell lectin like receptor C1"], ["ATG5", "0.327", "0.020137", "0.020137", "2.44253", "Up", "Autophagy related 5"], ["IL18R1", "0.713136", "0.020905", "0.020905", "2.426467", "Up", "Interleukin 18 receptor 1"], ["IKBKB", "0.1695", "0.027641", "0.027641", "2.304841", "Up", "Inhibitor of nuclear factor kappa B kinase subunit beta"], ["STAT5B", "0.2575", "0.032278", "0.032278", "2.235871", "Up", "Signal transducer and activator of transcription 5B"], ["MX1", "1.111727", "0.032817", "0.032817", "2.228441", "Up", "MX dynamin like GTPase 1"], ["IRF7", "0.898909", "0.033248", "0.033248", "2.222589", "Up", "Interferon regulatory factor 7"], ["TRAF2", "0.171955", "0.034273", "0.034273", "2.208908", "Up", "TNF receptor associated factor 2"], ["IFI35", "0.725909", "0.035093", "0.035093", "2.198229", "Up", "Interferon induced protein 35"], ["IKBKE", "0.236545", "0.035149", "0.035149", "2.197514", "Up", "Inhibitor of nuclear factor kappa B kinase subunit epsilon"], ["CLEC7A", "0.421227", "0.037828", "0.037828", "2.164155", "Up", "C-type lectin domain containing 7A"], ["LTB4R", "0.465227", "0.03902", "0.03902", "2.149988", "Up", "Leukotriene B4 receptor"], ["GZMB", "0.437364", "0.040654", "0.040654", "2.131179", "Up", "Granzyme B"], ["NLRP3", "0.290364", "0.04286", "0.04286", "2.106829", "Up", "NLR family pyrin domain containing 3"], ["LILRB2", "0.299364", "0.042931", "0.042931", "2.106059", "Up", "Leukocyte immunoglobulin like receptor B2"], ["IFNAR2", "0.184136", "0.048633", "0.048633", "2.047965", "Up", "Interferon alpha and beta receptor subunit 2"], ["KLRD1", "0.4455", "0.049759", "0.049759", "2.037205", "Up", "Killer cell lectin like receptor D1"], ["CD19", "− 1.7175", "5.18E − 16", "5.18E − 16", "− 14.7177", "Down", "CD19 molecule"], ["CD22", "− 1.757", "4.93E − 15", "4.93E − 15", "− 13.592", "Down", "CD22 molecule"], ["MS4A1", "− 1.67741", "1.67E − 14", "1.67E − 14", "− 13.0082", "Down", "Membrane spanning 4-domains A1"], ["CD45RB", "− 0.94709", "4.17E − 14", "4.17E − 14", "− 12.5832", "Down", "Receptor-Type Tyrosine-Protein Phosphatase C"], ["IL6R", "− 2.0375", "1.05E − 13", "1.05E − 13", "− 12.164", "Down", "interleukin 6 receptor"], ["TNFRSF13C", "− 1.46186", "2.18E − 13", "2.18E − 13", "− 11.8375", "Down", "TNF receptor superfamily member 13C"], ["PAX5", "− 1.37636", "2.92E − 13", "2.92E − 13", "− 11.7085", "Down", "Paired box 5"], ["CD79A", "− 1.29577", "2.53E − 12", "2.53E − 12", "− 10.7841", "Down", "CD79a molecule"], ["ARHGDIB", "− 0.65064", "3.68E − 12", "3.68E − 12", "− 10.6278", "Down", "Rho GDP dissociation inhibitor beta"], ["HLA-DQB1", "− 4.88305", "5.18E − 12", "5.18E − 12", "− 10.4865", "Down", "Major histocompatibility complex, class II, DQ beta 1"], ["HLA-DQA1", "− 6.1155", "1.8E − 11", "1.8E − 11", "− 9.98021", "Down", "Major histocompatibility complex, class II, DQ alpha 1"], ["MAPKAPK2", "− 0.99755", "5.49E − 11", "5.49E − 11", "− 9.53915", "Down", "MAPK activated protein kinase 2"], ["SLAMF6", "− 0.87414", "2.16E − 10", "2.16E − 10", "− 9.01008", "Down", "SLAM family member 6"], ["PTGER4", "− 0.76932", "2.43E − 10", "2.43E − 10", "− 8.96519", "Down", "Prostaglandin E receptor 4"], ["CD79B", "− 0.84082", "2.75E − 10", "2.75E − 10", "− 8.91788", "Down", "CD79b molecule"], ["CD97", "− 1.1985", "3.22E − 10", "3.22E − 10", "− 8.85915", "Down", "Leukocyte antigen CD97"], ["IL1RL2", "− 1.04873", "3.57E − 10", "3.57E − 10", "− 8.81964", "Down", "Interleukin 1 receptor like 2"], ["CD1A", "− 1.07114", "3.6E − 10", "3.6E − 10", "− 8.81626", "Down", "CD1a molecule"], ["IL1RAP", "− 1.43418", "8.92E − 10", "8.92E − 10", "− 8.47672", "Down", "Interleukin 1 receptor accessory protein"], ["TNFSF12", "− 0.53718", "2.42E − 09", "2.42E − 09", "− 8.10915", "Down", "TNF superfamily member 12"], ["AICDA", "− 0.94759", "2.89E − 09", "2.89E − 09", "− 8.04473", "Down", "Activation induced cytidinedeaminase"], ["MBP", "− 0.77614", "4.02E − 09", "4.02E − 09", "− 7.92468", "Down", "myelin basic protein"], ["TRAF4", "− 0.67777", "5.69E − 09", "5.69E − 09", "− 7.79888", "Down", "TNF receptor associated factor 4"], ["MIF", "− 0.59309", "5.94E − 09", "5.94E − 09", "− 7.78344", "Down", "Macrophage migration inhibitory factor"], ["CCBP2", "− 1.34027", "6.31E − 09", "6.31E − 09", "− 7.76207", "Down", "Chemokine-binding protein 2"], ["CCL22", "− 0.68986", "8.3E − 09", "8.3E − 09", "− 7.66358", "Down", "C–C motif chemokine ligand 22"], ["HLA-DRA", "− 1.87223", "9.28E − 09", "9.28E − 09", "− 7.62328", "Down", "Major histocompatibility complex, class II, DR alpha"], ["FCER1A", "− 2.15768", "9.79E − 09", "9.79E − 09", "− 7.60411", "Down", "Fc fragment of IgE receptor Ia"], ["LILRB5", "− 0.76595", "1.11E − 08", "1.11E − 08", "− 7.55809", "Down", "Leukocyte immunoglobulin like receptor B5"], ["CCL15", "− 0.7105", "1.48E − 08", "1.48E − 08", "− 7.4567", "Down", "C–C motif chemokine ligand 15"], ["IL12B", "− 0.99886", "1.5E − 08", "1.5E − 08", "− 7.45174", "Down", "Interleukin 12B"], ["TFRC", "− 1.07782", "1.61E − 08", "1.61E − 08", "− 7.42698", "Down", "Transferrin receptor"], ["EBI3", "− 0.72195", "1.86E − 08", "1.86E − 08", "− 7.37653", "Down", "Epstein-Barr virus induced 3"], ["IL4", "− 0.69941", "2.72E − 08", "2.72E − 08", "− 7.24189", "Down", "Interleukin 4"], ["ICAM2", "− 0.74745", "2.86E − 08", "2.86E − 08", "− 7.22422", "Down", "Intercellular adhesion molecule 2"], ["KLRAP1", "− 1.0865", "3.09E − 08", "3.09E − 08", "− 7.19683", "Down", "Killer cell lectin-like receptor subfamily A pseudogene 1"], ["CD40", "− 0.79436", "3.29E − 08", "3.29E − 08", "− 7.17439", "Down", "CD40 molecule"], ["IL22RA2", "− 0.6365", "4.34E − 08", "4.34E − 08", "− 7.07766", "Down", "Interleukin 22 receptor subunit alpha 2"], ["IL2", "− 0.64395", "4.65E − 08", "4.65E − 08", "− 7.05298", "Down", "Interleukin 2"], ["IL29", "− 0.64395", "4.65E − 08", "4.65E − 08", "− 7.05298", "Down", "Interleukin 29"], ["CD3E", "− 0.73018", "5.24E − 08", "5.24E − 08", "− 7.01159", "Down", "CD3e molecule"], ["CD55", "− 0.92114", "5.29E − 08", "5.29E − 08", "− 7.00828", "Down", "CD55 molecule (Cromer blood group)"], ["IL19", "− 0.6555", "5.33E − 08", "5.33E − 08", "− 7.00515", "Down", "Interleukin 19"], ["NOS2", "− 0.81432", "5.6E − 08", "5.6E − 08", "− 6.98829", "Down", "Nitric oxide synthase 2"], ["C4BPA", "− 1.83359", "5.78E − 08", "5.78E − 08", "− 6.97697", "Down", "Complement component 4 binding protein alpha"], ["CCL26", "− 0.57677", "6.5E − 08", "6.5E − 08", "− 6.93596", "Down", "C–C motif chemokine ligand 26"], ["CDH5", "− 0.60586", "7.09E − 08", "7.09E − 08", "− 6.90577", "Down", "Cadherin 5"], ["IL9", "− 0.60586", "7.09E − 08", "7.09E − 08", "− 6.90577", "Down", "Interleukin 9"], ["FCGRT", "− 0.75709", "8.18E − 08", "8.18E − 08", "− 6.85603", "Down", "Fc fragment of IgG receptor and transporter"], ["C8B", "− 0.6555", "1.1E − 07", "1.1E − 07", "− 6.75159", "Down", "Complement C8 beta chain"], ["IL5", "− 0.64086", "1.16E − 07", "1.16E − 07", "− 6.7344", "Down", "Interleukin 5"], ["PIGR", "− 0.66695", "1.33E − 07", "1.33E − 07", "− 6.68821", "Down", "Polymeric immunoglobulin receptor"], ["XCL1", "− 1.06423", "1.98E − 07", "1.98E − 07", "− 6.54928", "Down", "X-C motif chemokine ligand 1"], ["AIRE", "− 0.78032", "2.01E − 07", "2.01E − 07", "− 6.5441", "Down", "Autoimmune regulator"], ["IL3", "− 0.60723", "2.08E − 07", "2.08E − 07", "− 6.53283", "Down", "Interleukin 3"], ["CCL16", "− 0.6195", "2.31E − 07", "2.31E − 07", "− 6.4973", "Down", "C–C motif chemokine ligand 16"], ["CCL7", "− 0.6195", "2.31E − 07", "2.31E − 07", "− 6.4973", "Down", "C–C motif chemokine ligand 7"], ["CSF2", "− 0.6195", "2.31E − 07", "2.31E − 07", "− 6.4973", "Down", "Colony stimulating factor 2"], ["ITLN2", "− 0.6195", "2.31E − 07", "2.31E − 07", "− 6.4973", "Down", "Intelectin 2"], ["THY1", "− 0.6195", "2.31E − 07", "2.31E − 07", "− 6.4973", "Down", "Thy-1 cell surface antigen"], ["IL21", "− 0.70245", "3.28E − 07", "3.28E − 07", "− 6.37574", "Down", "Interleukin 21"], ["BCL2", "− 0.7385", "4.11E − 07", "4.11E − 07", "− 6.29854", "Down", "BCL2 apoptosis regulator"], ["EDNRB", "− 0.60541", "4.11E − 07", "4.11E − 07", "− 6.29833", "Down", "Endothelin receptor type B"], ["CCR6", "− 0.88205", "4.78E − 07", "4.78E − 07", "− 6.24666", "Down", "C–C motif chemokine receptor 6"], ["TIRAP", "− 0.70182", "5.91E − 07", "5.91E − 07", "− 6.17398", "Down", "TIR domain containing adaptor protein"], ["STAT6", "− 0.52186", "6.37E − 07", "6.37E − 07", "− 6.14848", "Down", "Signal transducer and activator of transcription 6"], ["PSMB10", "− 0.43945", "6.43E − 07", "6.43E − 07", "− 6.14519", "Down", "Proteasome 20S subunit beta 10"], ["SKI", "− 0.52182", "7.16E − 07", "7.16E − 07", "− 6.10886", "Down", "SKI proto-oncogene"], ["RAG2", "− 0.56723", "8.47E − 07", "8.47E − 07", "− 6.05149", "Down", "Recombination activating 2"], ["CD209", "− 0.7285", "8.56E − 07", "8.56E − 07", "− 6.04758", "Down", "CD209 molecule"], ["VTN", "− 0.68305", "9.43E − 07", "9.43E − 07", "− 6.01488", "Down", "Vitronectin"], ["IFNB1", "− 0.57768", "9.97E − 07", "9.97E − 07", "− 5.99573", "Down", "Interferon beta 1"], ["EOMES", "− 0.77505", "1.47E − 06", "1.47E − 06", "− 5.8643", "Down", "Eomesodermin"], ["CD74", "− 0.69905", "1.52E − 06", "1.52E − 06", "− 5.85145", "Down", "CD74 molecule"], ["CCR10", "− 0.60368", "1.7E − 06", "1.7E − 06", "− 5.81503", "Down", "C–C motif chemokine receptor 10"], ["LGALS3", "− 1.12309", "1.85E − 06", "1.85E − 06", "− 5.78563", "Down", "Galectin 3"], ["PDGFB", "− 0.64241", "1.86E − 06", "1.86E − 06", "− 5.78395", "Down", "Platelet derived growth factor subunit B"], ["ICAM4", "− 0.96814", "1.96E − 06", "1.96E − 06", "− 5.76557", "Down", "Intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)"], ["ICOSLG", "− 0.74791", "2.07E − 06", "2.07E − 06", "− 5.74698", "Down", "Inducible T cell costimulator ligand"], ["C9", "− 0.52132", "2.66E − 06", "2.66E − 06", "− 5.66169", "Down", "Complement C9"], ["IL16", "− 0.45973", "2.88E − 06", "2.88E − 06", "− 5.63467", "Down", "Interleukin 16"], ["RELA", "− 0.47205", "3.09E − 06", "3.09E − 06", "− 5.61097", "Down", "RELA proto-oncogene, NF-kB subunit"], ["DEFB1", "− 0.8105", "3.38E − 06", "3.38E − 06", "− 5.58051", "Down", "Defensin beta 1"], ["IL13RA1", "− 0.90159", "3.41E − 06", "3.41E − 06", "− 5.57755", "Down", "Interleukin 13 receptor subunit alpha 1"], ["HLA-DOB", "− 1.24595", "3.65E − 06", "3.65E − 06", "− 5.55493", "Down", "Major histocompatibility complex, class II, DO beta"], ["KIR3DL3", "− 0.56905", "3.78E − 06", "3.78E − 06", "− 5.54244", "Down", "Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3"], ["HLA-C", "− 0.93941", "3.97E − 06", "3.97E − 06", "− 5.52568", "Down", "Major histocompatibility complex, class I, C"], ["KLRB1", "− 1.79632", "5.31E − 06", "5.31E − 06", "− 5.42732", "Down", "Killer cell lectin like receptor B1"], ["HLA-DMB", "− 0.85005", "5.86E − 06", "5.86E − 06", "− 5.39367", "Down", "Major histocompatibility complex, class II, DM beta"], ["KLRF2", "− 0.53859", "6E − 06", "6E − 06", "− 5.3857", "Down", "Killer cell lectin like receptor F2"], ["ICAM3", "− 0.66718", "6.38E − 06", "6.38E − 06", "− 5.36481", "Down", "Intercellular adhesion molecule 3"], ["IL28A", "− 0.55718", "7.03E − 06", "7.03E − 06", "− 5.33194", "Down", "Interleukin 28A"], ["SIGIRR", "− 0.41545", "7.52E − 06", "7.52E − 06", "− 5.30925", "Down", "Single Ig and TIR domain containing"], ["MASP2", "− 0.68927", "7.93E − 06", "7.93E − 06", "− 5.29109", "Down", "Mannan binding lectin serine peptidase 2"], ["CSF2RB", "− 1.12332", "8.36E − 06", "8.36E − 06", "− 5.27318", "Down", "Colony stimulating factor 2 receptor beta common subunit"], ["CD46", "− 0.59905", "9.11E − 06", "9.11E − 06", "− 5.24408", "Down", "CD46 molecule"], ["S1PR1", "− 0.60436", "9.23E − 06", "9.23E − 06", "− 5.23966", "Down", "Sphingosine − 1-phosphate receptor 1"], ["TLR9", "− 0.56841", "1.05E − 05", "1.05E − 05", "− 5.19438", "Down", "Toll like receptor 9"], ["HLA-DPB1", "− 0.70064", "1.07E − 05", "1.07E − 05", "− 5.19046", "Down", "Major histocompatibility complex, class II, DP beta 1"], ["CCL13", "− 0.57018", "1.16E − 05", "1.16E − 05", "− 5.16161", "Down", "C–C motif chemokine ligand 13"], ["PLA2G2E", "− 0.67155", "1.19E − 05", "1.19E − 05", "-5.15362", "Down", "Phospholipase A2 group IIE"], ["IL20", "− 0.67032", "1.29E − 05", "1.29E − 05", "-5.12687", "Down", "Interleukin 20"], ["PTAFR", "− 0.91373", "1.37E − 05", "1.37E − 05", "-5.10671", "Down", "Platelet activating factor receptor"], ["TGFBI", "− 0.59209", "1.44E − 05", "1.44E − 05", "-5.08943", "Down", "Transforming growth factor beta induced"], ["IL26", "− 0.50514", "1.52E − 05", "1.52E − 05", "-5.07029", "Down", "Interleukin 26"], ["IFNAR1", "− 0.78755", "2.03E − 05", "2.03E − 05", "− 4.97214", "Down", "Interferon alpha and beta receptor subunit 1"], ["LTA", "− 0.56282", "2.17E − 05", "2.17E − 05", "− 4.94915", "Down", "Lymphotoxin alpha"], ["FCGR2B", "− 0.85355", "2.4E − 05", "2.4E − 05", "− 4.91443", "Down", "Fc fragment of IgG receptor IIb"], ["EGR1", "− 0.63082", "2.41E − 05", "2.41E − 05", "− 4.9133", "Down", "Early growth response 1"], ["CD86", "− 0.76691", "2.54E − 05", "2.54E − 05", "− 4.89525", "Down", "CD86 molecule"], ["CD82", "− 0.99568", "2.76E − 05", "2.76E − 05", "− 4.86674", "Down", "CD82 molecule"], ["CD34", "− 0.56045", "2.79E − 05", "2.79E − 05", "− 4.86293", "Down", "CD34 molecule"], ["TRAF3", "− 0.46214", "2.87E − 05", "2.87E − 05", "− 4.85429", "Down", "TNF receptor associated factor 3"], ["CTLA4", "− 0.53577", "3E − 05", "3E − 05", "− 4.83886", "Down", "Cytotoxic T-Lymphocyte Associated Protein 4"], ["HAMP", "− 0.61205", "3E − 05", "3E − 05", "− 4.83856", "Down", "Hepcidin antimicrobial peptide"], ["EGR2", "− 0.78873", "3.15E − 05", "3.15E − 05", "− 4.82228", "Down", "Early growth response 2"], ["ICAM5", "− 0.53214", "3.22E − 05", "3.22E − 05", "− 4.81493", "Down", "Intercellular adhesion molecule 5"], ["CSF1R", "− 0.70273", "3.45E − 05", "3.45E − 05", "− 4.79056", "Down", "Colony stimulating factor 1 receptor"], ["NT5E", "− 0.85836", "3.68E − 05", "3.68E − 05", "− 4.76884", "Down", "5′-nucleotidase ecto"], ["IL7", "− 0.74464", "4.3E − 05", "4.3E − 05", "− 4.71548", "Down", "Interleukin 7"], ["CTSS", "− 0.62991", "4.34E − 05", "4.34E − 05", "− 4.71277", "Down", "Cathepsin S"], ["IL17B", "− 0.55268", "4.82E − 05", "4.82E − 05", "− 4.6769", "Down", "Interleukin 17B"], ["CR2", "− 1.00786", "4.86E − 05", "4.86E − 05", "− 4.67369", "Down", "Complement C3d receptor 2"], ["CD44", "− 0.35164", "5.25E − 05", "5.25E − 05", "− 4.64701", "Down", "CD44 molecule (Indian blood group)"], ["PLA2G2A", "− 0.53655", "5.77E − 05", "5.77E − 05", "− 4.61492", "Down", "Phospholipase A2 group IIA"], ["BTK", "− 0.45495", "5.87E − 05", "5.87E − 05", "− 4.60896", "Down", "Bruton tyrosine kinase"], ["C6", "− 0.65964", "5.95E − 05", "5.95E − 05", "− 4.60439", "Down", "Complement C6"], ["IRGM", "− 0.62291", "6.21E − 05", "6.21E − 05", "− 4.58953", "Down", "Immunity related GTPase M"], ["IL22", "− 0.65314", "7.15E − 05", "7.15E − 05", "− 4.54121", "Down", "Interleukin 22"], ["CEBPB", "− 0.88709", "7.69E − 05", "7.69E − 05", "− 4.51625", "Down", "CCAAT enhancer binding protein beta"], ["IL6", "− 0.69105", "7.91E − 05", "7.91E − 05", "− 4.50639", "Down", "Interleukin 6"], ["IFNA2", "− 0.77586", "8.23E − 05", "8.23E − 05", "− 4.49296", "Down", "Interferon alpha 2"], ["TGFBR1", "− 0.40336", "8.66E − 05", "8.66E − 05", "− 4.47511", "Down", "Transforming growth factor beta receptor 1"], ["IL17F", "− 0.54009", "8.83E − 05", "8.83E − 05", "− 4.4686", "Down", "Interleukin 17F"], ["IL28A/B", "− 0.55282", "0.000163", "0.000163", "− 4.25674", "Down", "Interleukin 28A/B"], ["IL17A", "− 0.53723", "0.00018", "0.00018", "− 4.22236", "Down", "Interleukin 17A"], ["LILRA2", "− 0.68495", "0.000195", "0.000195", "− 4.194", "Down", "Leukocyte immunoglobulin like receptor A2"], ["LILRA3", "− 2.33691", "0.000203", "0.000203", "− 4.18055", "Down", "Leukocyte immunoglobulin like receptor A3"], ["VCAM1", "− 0.60605", "0.000219", "0.000219", "− 4.15259", "Down", "Vascular cell adhesion molecule 1"], ["SPP1", "− 0.6555", "0.000221", "0.000221", "− 4.1496", "Down", "Secreted phosphoprotein 1"], ["CARD9", "− 0.55227", "0.000269", "0.000269", "− 4.0818", "Down", "Caspase recruitment domain family member 9"], ["LCK", "− 0.40364", "0.000299", "0.000299", "− 4.04398", "Down", "LCK proto-oncogene, Src family tyrosine kinase"], ["SELE", "− 0.52332", "0.000306", "0.000306", "− 4.03551", "Down", "selectin E"], ["SLC2A1", "− 0.44118", "0.00036", "0.00036", "− 3.97865", "Down", "solute carrier family 2 member 1"], ["LIF", "− 0.50555", "0.000368", "0.000368", "− 3.97037", "Down", "LIF interleukin 6 family cytokine"], ["IDO1", "− 0.95541", "0.000417", "0.000417", "− 3.92685", "Down", "Indoleamine 2,3-dioxygenase 1"], ["TNFRSF10C", "− 0.88564", "0.000471", "0.000471", "− 3.88294", "Down", "TNF receptor superfamily member 10c"], ["IL23A", "− 0.87541", "0.000557", "0.000557", "− 3.82374", "Down", "interleukin 23 subunit alpha"], ["CD80", "− 0.58964", "0.000567", "0.000567", "− 3.81702", "Down", "CD80 molecule"], ["GPR183", "− 1.088", "0.00057", "0.00057", "− 3.81527", "Down", "G protein-coupled receptor 183"], ["C1R", "− 0.41727", "0.000592", "0.000592", "− 3.8018", "Down", "Complement C1r"], ["CCL11", "− 0.55055", "0.000611", "0.000611", "− 3.79064", "Down", "C–C motif chemokine ligand 11"], ["HLA-DPA1", "− 0.6385", "0.000637", "0.000637", "− 3.77577", "Down", "major histocompatibility complex, class II, DP alpha 1"], ["IFNG", "− 0.877", "0.00073", "0.00073", "− 3.72658", "Down", "Interferon gamma"], ["DUSP4", "− 0.70741", "0.000789", "0.000789", "− 3.69861", "Down", "Dual specificity phosphatase 4"], ["IL27", "− 0.44905", "0.000852", "0.000852", "− 3.67089", "Down", "Interleukin 27"], ["CD48", "− 1.15805", "0.000953", "0.000953", "− 3.6304", "Down", "CD48 molecule"], ["FN1", "− 0.56177", "0.001005", "0.001005", "− 3.61111", "Down", "fibronectin 1"], ["CD244", "− 0.39427", "0.001018", "0.001018", "− 3.60646", "Down", "CD244 molecule"], ["PPBP", "− 1.35464", "0.001091", "0.001091", "− 3.58105", "Down", "pro-platelet basic protein"], ["IL13", "− 0.599", "0.001204", "0.001204", "− 3.54515", "Down", "interleukin 13"], ["CCL24", "− 0.45395", "0.001221", "0.001221", "− 3.53987", "Down", "C–C motif chemokine ligand 24"], ["GATA3", "− 0.55041", "0.001228", "0.001228", "− 3.53797", "Down", "GATA binding protein 3"], ["BID", "− 0.46636", "0.001281", "0.001281", "− 3.52243", "Down", "BH3 interacting domain death agonist"], ["BCL2L11", "− 0.40091", "0.001565", "0.001565", "− 3.44881", "Down", "BCL2 like 11"], ["KIT", "− 0.52868", "0.001589", "0.001589", "− 3.44316", "Down", "KIT proto-oncogene, receptor tyrosine kinase"], ["MME", "− 1.00591", "0.001596", "0.001596", "− 3.44151", "Down", "Membrane metalloendopeptidase"], ["ZEB1", "− 0.38082", "0.001667", "0.001667", "− 3.42548", "Down", "Zinc finger E-box binding homeobox 1"], ["C4A/B", "− 0.62314", "0.001738", "0.001738", "− 3.40994", "Down", "Complement C4A/B"], ["FCAR", "− 0.50423", "0.00198", "0.00198", "− 3.36169", "Down", "Fc fragment of IgA receptor"], ["BTLA", "− 0.45623", "0.002033", "0.002033", "− 3.35183", "Down", "B and T lymphocyte associated"], ["TAGAP", "− 0.38886", "0.002261", "0.002261", "− 3.31206", "Down", "T cell activation RhoGTPase activating protein"], ["CD83", "− 0.39914", "0.002292", "0.002292", "− 3.307", "Down", "CD83 molecule"], ["SELPLG", "− 0.37564", "0.002362", "0.002362", "-3.29575", "Down", "Selectin P ligand"], ["B3GAT1", "− 0.66791", "0.002423", "0.002423", "− 3.28614", "Down", "Beta-1,3-glucuronyltransferase 1"], ["CCRL1", "− 0.39195", "0.002543", "0.002543", "− 3.26788", "Down", "C–C chemokine receptor type 11"], ["TNFRSF14", "− 0.29986", "0.002557", "0.002557", "− 3.26588", "Down", "TNF receptor superfamily member 14"], ["CSF3R", "− 0.65318", "0.003003", "0.003003", "− 3.20507", "Down", "Colony stimulating factor 3 receptor"], ["CD9", "− 0.87091", "0.003004", "0.003004", "− 3.20497", "Down", "CD9 molecule"], ["C1S", "− 0.52059", "0.003211", "0.003211", "− 3.17969", "Down", "complement C1s"], ["PECAM1", "− 0.30873", "0.003251", "0.003251", "− 3.17496", "Down", "platelet and endothelial cell adhesion molecule 1"], ["DEFB103B", "− 0.4315", "0.003466", "0.003466", "− 3.15055", "Down", "Defensin beta 103B"], ["ITLN1", "− 1.17682", "0.003488", "0.003488", "− 3.14815", "Down", "Intelectin 1"], ["CXCL13", "− 0.46586", "0.003554", "0.003554", "− 3.14101", "Down", "C-X-C motif chemokine ligand 13"], ["RAG1", "− 0.47836", "0.003917", "0.003917", "− 3.10376", "Down", "Recombination activating 1"], ["TNFRSF4", "− 0.55123", "0.004154", "0.004154", "− 3.08112", "Down", "TNF receptor superfamily member 4"], ["C14orf166", "− 0.35727", "0.004255", "0.004255", "− 3.07189", "Down", "Chromosome 14 open reading frame 166"], ["IL10RA", "− 0.26059", "0.004423", "0.004423", "− 3.0569", "Down", "Interleukin 10 receptor subunit alpha"], ["POU2F2", "− 0.292", "0.004614", "0.004614", "− 3.04059", "Down", "POU class 2 homeobox 2"], ["C7", "− 0.41223", "0.004688", "0.004688", "− 3.03441", "Down", "complement C7"], ["RORC", "− 0.52768", "0.005006", "0.005006", "− 3.00891", "Down", "RAR related orphan receptor C"], ["CXCL11", "− 0.83891", "0.005151", "0.005151", "− 2.99784", "Down", "C-X-C motif chemokine ligand 11"], ["MASP1", "− 0.50677", "0.005182", "0.005182", "− 2.99543", "Down", "Mannan binding lectin serine peptidase 1"], ["MAP4K4", "− 0.37777", "0.005449", "0.005449", "− 2.97583", "Down", "Mitogen-activated protein kinase kinasekinasekinase 4"], ["CX3CL1", "− 0.50445", "0.005597", "0.005597", "− 2.96535", "Down", "C-X3-C motif chemokine ligand 1"], ["BATF3", "− 0.62586", "0.005862", "0.005862", "− 2.94725", "Down", "Basic leucine zipper ATF-like transcription factor 3"], ["CCR8", "− 0.51627", "0.005946", "0.005946", "− 2.94164", "Down", "C–C motif chemokine receptor 8"], ["TAL1", "− 1.01455", "0.006016", "0.006016", "− 2.93707", "Down", "TAL bHLH transcription factor 1, erythroid differentiation factor"], ["NFIL3", "− 0.723", "0.007", "0.007", "− 2.87725", "Down", "Nuclear factor, interleukin 3 regulated"], ["CD8A", "− 0.50595", "0.007337", "0.007337", "− 2.85858", "Down", "CD8a molecule"], ["CLEC6A", "− 0.62323", "0.007445", "0.007445", "− 2.85274", "Down", "C-type lectin domain containing 6A"], ["TCF4", "− 0.37827", "0.007904", "0.007904", "− 2.8289", "Down", "Transcription factor 4"], ["FCGR2A", "− 0.664", "0.009089", "0.009089", "− 2.77283", "Down", "Fc fragment of IgG receptor IIa"], ["HLA-B", "− 0.31677", "0.00918", "0.00918", "− 2.76877", "Down", "major histocompatibility complex, class I, B"], ["IRF8", "− 0.39477", "0.009346", "0.009346", "− 2.76157", "Down", "Interferon regulatory factor 8"], ["MAPK11", "− 0.60427", "0.010152", "0.010152", "− 2.72804", "Down", "Mitogen-activated protein kinase 11"], ["ILF3", "− 0.17055", "0.010366", "0.010366", "− 2.71958", "Down", "Interleukin enhancer binding factor 3"], ["XCR1", "− 0.34541", "0.01065", "0.01065", "− 2.70856", "Down", "X–C motif chemokine receptor 1"], ["ITGAE", "− 0.33509", "0.011424", "0.011424", "− 2.67988", "Down", "Integrin subunit alpha E"], ["IL4R", "− 0.69064", "0.012538", "0.012538", "− 2.64162", "Down", "Interleukin 4 receptor"], ["CTSC", "− 0.16718", "0.012619", "0.012619", "− 2.63897", "Down", "Cathepsin C"], ["ETS1", "− 0.39405", "0.013255", "0.013255", "− 2.61865", "Down", "ETS proto-oncogene 1, transcription factor"], ["CFI", "− 0.30082", "0.013335", "0.013335", "− 2.61614", "Down", "Complement factor I"], ["STAT5A", "− 0.27168", "0.014802", "0.014802", "− 2.57273", "Down", "Signal transducer and activator of transcription 5A"], ["C8A", "− 0.37964", "0.016204", "0.016204", "− 2.53478", "Down", "Complement C8 alpha chain"], ["DEFB4A", "− 0.36691", "0.017835", "0.017835", "− 2.49428", "Down", "Defensin beta 4A"], ["RELB", "− 0.45095", "0.019351", "0.019351", "− 2.45958", "Down", "RELB proto-oncogene, NF-kB subunit"], ["ATG7", "− 0.32859", "0.01984", "0.01984", "− 2.4489", "Down", "Autophagy related 7"], ["DPP4", "− 0.38823", "0.01999", "0.01999", "− 2.44568", "Down", "Dipeptidyl peptidase 4"], ["GPI", "− 0.21382", "0.020424", "0.020424", "− 2.43646", "Down", "Glucose-6-phosphate isomerase"], ["CD59", "− 0.24032", "0.020561", "0.020561", "− 2.43359", "Down", "CD59 molecule (CD59 blood group)"], ["CASP3", "− 0.40573", "0.025629", "0.025629", "− 2.33807", "Down", "Caspase 3"], ["TIGIT", "− 0.3615", "0.025963", "0.025963", "− 2.33239", "Down", "T cell immunoreceptor with Ig and ITIM domains"], ["CFD", "− 0.36627", "0.026073", "0.026073", "− 2.33053", "Down", "Complement factor D"], ["CCL18", "− 0.42077", "0.026944", "0.026944", "− 2.3161", "Down", "C–C motif chemokine ligand 18"], ["PLAU", "− 0.34086", "0.028132", "0.028132", "− 2.29706", "Down", "Plasminogen activator, urokinase"], ["PTPN22", "− 0.20086", "0.028829", "0.028829", "− 2.28623", "Down", "Protein tyrosine phosphatase non-receptor type 22"], ["TOLLIP", "− 0.27377", "0.028911", "0.028911", "− 2.28497", "Down", "Toll interacting protein"], ["CXCR2", "− 0.49195", "0.029438", "0.029438", "− 2.27696", "Down", "C-X-C motif chemokine receptor 2"], ["CCL20", "− 0.34555", "0.029871", "0.029871", "− 2.27048", "Down", "C–C motif chemokine ligand 20"], ["IL12A", "− 0.40759", "0.03046", "0.03046", "− 2.26179", "Down", "Interleukin 12A"], ["IL10", "− 0.33555", "0.03205", "0.03205", "− 2.23904", "Down", "Interleukin 10"], ["LILRA1", "− 0.26991", "0.033542", "0.033542", "− 2.21862", "Down", "leukocyte immunoglobulin like receptor A1"], ["PTPN6", "− 0.16109", "0.034722", "0.034722", "− 2.20304", "Down", "protein tyrosine phosphatase non-receptor type 6"], ["CCL19", "− 0.37718", "0.035605", "0.035605", "− 2.19168", "Down", "C–C motif chemokine ligand 19"], ["IKBKAP", "− 0.15505", "0.035624", "0.035624", "− 2.19144", "Down", "IκB kinase complex-associated protein"], ["TNFRSF9", "− 0.50786", "0.036235", "0.036235", "− 2.18372", "Down", "TNF receptor superfamily member 9"], ["TCF7", "− 0.60091", "0.036564", "0.036564", "− 2.17963", "Down", "Transcription factor 7"], ["HLA-DMA", "− 0.30777", "0.036925", "0.036925", "− 2.17516", "Down", "Major histocompatibility complex, class II, DM alpha"], ["CXCL12", "− 0.69291", "0.037168", "0.037168", "− 2.17218", "Down", "C-X-C motif chemokine ligand 12"], ["MBL2", "− 0.37009", "0.037623", "0.037623", "− 2.16664", "Down", "Mannose binding lectin 2"], ["IKZF2", "− 0.46655", "0.039489", "0.039489", "− 2.14452", "Down", "IKAROS family zinc finger 2"], ["BCAP31", "− 0.10632", "0.04075", "0.04075", "− 2.13009", "Down", "B cell receptor associated protein 31"], ["HLA-DRB1", "− 1.39495", "0.041403", "0.041403", "− 2.12278", "Down", "Major histocompatibility complex, class II, DR beta 1"], ["IRAK4", "− 0.23727", "0.041428", "0.041428", "− 2.12251", "Down", "Interleukin 1 receptor associated kinase 4"], ["CXCR1", "− 0.49741", "0.041833", "0.041833", "− 2.11802", "Down", "C-X-C motif chemokine receptor 1"], ["PTK2", "− 0.33609", "0.043242", "0.043242", "− 2.10272", "Down", "Protein tyrosine kinase 2"], ["CD45R0", "− 0.46514", "0.043373", "0.043373", "− 2.10132", "Down", "A member of leucocyte common antigen family"]], "row_count": 325, "column_count": 7, "numeric_cells": 1605, "header_rows": 1, "locator": "section[12]/table-wrap[1]#Tab1"}}, {"id": "asset:table:pmid:33251083:10", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:b7239eaa56eb9da9deefd70f1c000d77539072c6a251173f715314d5547a318e", "bytes": 10374, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[13]/table-wrap[1]#Tab2", "version": null, "note": "The enriched pathway terms of the up regulated differentially expressed genes", "structure": {"pmcid": "PMC7679428", "section_index": 13, "section_title": "Pathway enrichment analysis for DEGs", "row_count": 73, "column_count": 8}, "table": {"label": "Table 2", "caption": "The enriched pathway terms of the up regulated differentially expressed genes", "rows": [["KEGG"], ["Pathway ID", "Pathway Name", "P-value", "FDR B&H", "FDR B&Y", "Bonferroni", "Gene Count", "Gene"], ["213306", "Measles", "3.21E − 17", "4.46E − 15", "2.46E − 14", "4.46E − 15", "16", "CCND3, JAK1, JAK2, IFIH1, TRAF6, IKBKE, TLR2, IRF7, FYN, IL2RG, STAT1, TP53, STAT3, MX1, STAT5B, IFNAR2"], ["377873", "Herpes simplex infection", "1.19E − 13", "8.24E − 12", "4.54E − 11", "1.65E − 11", "15", "JAK1, JAK2, IFIH1, TRAF2, TRAF6, HLA-A, IKBKE, TLR2, C1QBP, CCL5, IRF7, IKBKB, STAT1, TP53, IFNAR2"], ["83079", "Natural killer cell mediated cytotoxicity", "5.40E − 13", "2.50E − 11", "1.38E − 10", "7.51E − 11", "13", "KLRK1, CD247, HLA-A, GZMB, HRAS, LCP2, ITGAL, FYN, ITGB2, KLRC1, ZAP70, KLRD1, IFNAR2"], ["193147", "Osteoclast differentiation", "1.85E − 10", "3.32E − 09", "1.83E − 08", "2.57E − 08", "11", "JAK1, TRAF2, TRAF6, LILRB2, LILRA6, SOCS1, IKBKB, LCP2, FYN, STAT1, IFNAR2"], ["83077", "Jak-STAT signaling pathway", "1.31E − 09", "1.83E − 08", "1.01E − 07", "1.83E − 07", "11", "CCND3, JAK1, JAK2, HRAS, SOCS1, IL2RG, STAT1, STAT3, STAT4, STAT5B, IFNAR2"], ["217173", "Influenza A", "3.94E − 09", "4.56E − 08", "2.51E − 07", "5.47E − 07", "11", "JAK1, JAK2, IFIH1, IKBKE, CCL5, IRF7, IKBKB, STAT1, NLRP3, MX1, IFNAR2"], ["373901", "HTLV-I infection", "2.27E − 08", "2.11E − 07", "1.16E − 06", "3.16E − 06", "12", "CCND3, JAK1, HLA-A, HRAS, XBP1, CTNNB1, IKBKB, ITGAL, ITGB2, IL2RG, TP53, STAT5B"], ["658418", "Viral carcinogenesis", "2.16E − 07", "1.67E − 06", "9.20E − 06", "3.00E − 05", "10", "CCND3, JAK1, TRAF2, HLA-A, HRAS, IRF7, CCR5, TP53, STAT3, STAT5B"], ["83080", "T cell receptor signaling pathway", "2.05E − 06", "1.36E − 05", "7.47E − 05", "2.85E − 04", "7", "PDCD1, CD247, HRAS, IKBKB, LCP2, FYN, ZAP70"], ["125138", "Viral myocarditis", "2.21E − 05", "1.18E − 04", "6.51E − 04", "3.07E − 03", "5", "ABL1, HLA-A, ITGAL, FYN, ITGB2"], ["213780", "Tuberculosis", "7.57E − 05", "3.63E − 04", "2.00E − 03", "1.05E − 02", "7", "JAK1, JAK2, TRAF6, TLR2, CLEC7A, ITGB2, STAT1"], ["83051", "Cytokine-cytokine receptor interaction", "1.59E − 04", "6.69E − 04", "3.69E − 03", "2.21E − 02", "8", "CCR1, CCL5, CCR5, IL18RAP, IL2RG, IL18R1, CX3CR1, IFNAR2"], ["152665", "Malaria", "1.79E − 04", "7.32E − 04", "4.04E − 03", "2.49E − 02", "4", "KLRK1, TLR2, ITGAL, ITGB2"], ["Pathway interaction database"], ["137922", "IL12-mediated signaling events", "1.37E − 17", "1.56E − 15", "8.29E − 15", "1.56E − 15", "13", "JAK2, CD247, HLA-A, TBX21, GZMB, SOCS1, CCR5, IL18RAP, IL2RG, IL18R1, STAT1, STAT3, STAT4"], ["137976", "IL2-mediated signaling events", "5.15E − 10", "2.94E − 08", "1.56E − 07", "5.88E − 08", "8", "JAK1, IKZF3, SOCS1, FYN, IL2RG, STAT1, STAT3, STAT5B"], ["138055", "TCR signaling in naive CD8 + T cells", "9.79E − 09", "2.35E − 07", "1.25E − 06", "1.12E − 06", "7", "TRAF6, CD247, HLA-A, IKBKB, LCP2, FYN, ZAP70"], ["138071", "PDGFR-beta signaling pathway", "6.28E − 07", "7.16E − 06", "3.81E − 05", "7.16E − 05", "6", "ABL1, HRAS, FYN, STAT1, STAT3, STAT5B"], ["137988", "IL2 signaling events mediated by STAT5", "2.52E − 05", "2.21E − 04", "1.17E − 03", "2.87E − 03", "4", "CCND3, JAK1, IL2RG, STAT5B"], ["138019", "p75(NTR)-mediated signaling", "5.25E − 03", "2.32E − 02", "1.23E − 01", "5.99E − 01", "3", "TRAF6, IKBKB, TP53"], ["138021", "Paxillin-dependent events mediated by a4b1", "5.29E − 03", "2.32E − 02", "1.23E − 01", "6.03E − 01", "2", "ITGAL, ITGB2"], ["137940", "Signaling events mediated by VEGFR1 and VEGFR2", "5.75E − 03", "2.43E − 02", "1.29E − 01", "6.55E − 01", "3", "HRAS, CTNNB1, FYN"], ["137983", "ALK2 signaling events", "6.18E − 02", "1.22E − 01", "6.47E − 01", "1.00E + 00", "1", "SMAD5"], ["138046", "Syndecan-1-mediated signaling events", "9.40E − 02", "1.70E − 01", "9.04E − 01", "1.00E + 00", "1", "CCL5"], ["REACTOME"], ["1269310", "Cytokine Signaling in Immune system", "3.94E − 16", "2.05E − 13", "1.40E − 12", "2.05E − 13", "28", "JAK1, JAK2, TRAF2, TRAF6, HLA-A, BST2, HRAS, PSMB9, GBP1, SOCS1, CCR1, IRF5, CCL5, IRF7, CCR5, IKBKB, FYN, IFI35, IL18RAP, ITGB2, IL2RG, IL18R1, STAT1, TP53, STAT3, MX1, STAT5B, IFNAR2"], ["1269203", "Innate Immune System", "1.61E − 13", "4.19E − 11", "2.86E − 10", "8.38E − 11", "32", "KLRK1, ATG5, JAK1, JAK2, IFIH1, TRAF2, TRAF6, CD247, ABL1, HLA-A, IKBKE, BST2, LILRB2, TLR2, HRAS, PSMB9, CLEC7A, SOCS1, C2, IRF7, GNLY, CTNNB1, IKBKB, LCP2, ITGAL, FYN, ITGB2, IL2RG, KLRD1, TP53, NLRP3, CEACAM1"], ["1269318", "Signaling by Interleukins", "9.69E − 11", "1.06E − 08", "7.24E − 08", "5.04E − 08", "19", "JAK1, JAK2, TRAF6, HRAS, PSMB9, SOCS1, CCR1, CCL5, CCR5, IKBKB, FYN, IL18RAP, ITGB2, IL2RG, IL18R1, STAT1, TP53, STAT3, STAT5B"], ["1269171", "Adaptive Immune System", "1.02E − 10", "1.06E − 08", "7.24E − 08", "5.30E − 08", "23", "KLRK1, PDCD1, TRAF6, CD247, ZBTB16, HLA-A, LILRB2, TLR2, LAG3, HRAS, LILRA6, PSMB9, SOCS1, SLAMF7, IKBKB, LCP2, ITGAL, FYN, ITGB2, KLRC1, ZAP70, KLRD1, TP53"], ["1269340", "Hemostasis", "5.49E − 07", "2.20E − 05", "1.50E − 04", "2.86E − 04", "16", "JAK1, JAK2, ABL1, CD99, HRAS, C1QBP, SERPING1, IRF7, LCP2, ITGAL, FYN, ITGB2, IL2RG, TP53, CEACAM1, GP1BB"], ["1269260", "TRAF3-dependent IRF activation pathway", "9.84E − 05", "1.55E − 03", "1.06E − 02", "5.12E − 02", "3", "IFIH1, IKBKE, IRF7"], ["1268854", "Disease", "1.26E − 03", "1.24E − 02", "8.44E − 02", "6.55E − 01", "13", "JAK2, CD247, HLA-A, TLR2, HRAS, PSMB9, CCR5, CTNNB1, IKBKB, FYN, STAT1, STAT3, STAT5B"], ["1268855", "Diseases of signal transduction", "1.35E − 03", "1.30E − 02", "8.90E − 02", "7.03E − 01", "8", "JAK2, HRAS, PSMB9, CTNNB1, FYN, STAT1, STAT3, STAT5B"], ["1269562", "Leukotriene receptors", "2.86E − 02", "8.96E − 02", "6.12E − 01", "1.00E + 00", "1", "LTB4R"], ["1269248", "Activation of C3 and C5", "3.98E − 02", "1.18E − 01", "8.08E − 01", "1.00E + 00", "1", "C2"], ["MSigDB C2 BIOCARTA (v6.0)"], ["M8066", "IL22 Soluble Receptor Signaling Pathway", "2.31E − 10", "3.56E − 08", "2.00E − 07", "3.56E − 08", "6", "JAK1, JAK2, STAT1, STAT3, STAT4, STAT5B"], ["M13494", "Bioactive Peptide Induced Signaling Pathway", "4.38E − 09", "3.38E − 07", "1.90E − 06", "6.75E − 07", "7", "JAK2, HRAS, FYN, STAT1, STAT3, STAT4, STAT5B"], ["M1462", "CTL mediated immune response against target cells", "1.61E − 08", "7.50E − 07", "4.21E − 06", "2.48E − 06", "5", "CD247, HLA-A, GZMB, ITGAL, ITGB2"], ["M6231", "NO2-dependent IL 12 Pathway in NK cells", "2.31E − 06", "3.24E − 05", "1.82E − 04", "3.56E − 04", "4", "JAK2, CD247, CCR5, STAT4"], ["M13863", "MAPKinaseSignaling Pathway", "1.06E − 05", "1.08E − 04", "6.09E − 04", "1.63E − 03", "6", "TRAF2, MAP4K1, HRAS, IKBKB, MAP4K2, STAT1"], ["M6427", "T Helper Cell Surface Molecules", "6.45E − 05", "4.73E − 04", "2.66E − 03", "9.93E − 03", "3", "CD247, ITGAL, ITGB2"], ["M4047", "Selective expression of chemokine receptors during T-cell polarization", "6.08E − 04", "3.12E − 03", "1.75E − 02", "9.37E − 02", "3", "CCR1, CCR5, IL18R1"], ["M11358", "Tumor Suppressor Arf Inhibits Ribosomal Biogenesis", "4.24E − 03", "1.28E − 02", "7.19E − 02", "6.53E − 01", "2", "ABL1, TP53"], ["M17400", "ALK in cardiac myocytes", "1.93E − 02", "4.37E − 02", "2.45E − 01", "1.00E + 00", "2", "CTNNB1, SMAD5"], ["M5885", "Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors", "8.19E − 01", "8.30E − 01", "1.00E + 00", "1.00E + 00", "3", "CLEC7A, SERPING1, CCL5"], ["Panther DB"], ["P00038", "JAK/STAT signaling pathway", "1.76E − 12", "5.64E − 11", "2.29E − 10", "5.64E − 11", "7", "JAK1, JAK2, SOCS1, STAT1, STAT3, STAT4, STAT5B"], ["P00031", "Inflammation mediated by chemokine and cytokine signaling pathway", "1.44E − 06", "2.31E − 05", "9.37E − 05", "4.62E − 05", "9", "JAK2, CCRL2, CCR1, CCL5, CCR5, IKBKB, ITGAL, CX3CR1, STAT3"], ["P00054", "Toll receptor signaling pathway", "1.94E − 04", "1.03E − 03", "4.19E − 03", "6.20E − 03", "4", "TRAF6, IKBKE, TLR2, IKBKB"], ["P00006", "Apoptosis signaling pathway", "3.03E − 04", "1.39E − 03", "5.62E − 03", "9.69E − 03", "5", "TRAF2, GZMB, IKBKB, MAP4K2, TP53"], ["P00010", "B cell activation", "4.43E − 02", "9.45E − 02", "3.83E − 01", "1.00E + 00", "2", "HRAS, IKBKB"], ["P00052", "TGF-beta signaling pathway", "9.73E − 02", "1.67E − 01", "6.78E − 01", "1.00E + 00", "2", "HRAS, SMAD5"], ["P00011", "Blood coagulation", "2.07E − 01", "2.89E − 01", "1.00E + 00", "1.00E + 00", "1", "GP1BB"], ["P00012", "Cadherin signaling pathway", "2.34E − 01", "3.00E − 01", "1.00E + 00", "1.00E + 00", "2", "CTNNB1, FYN"], ["P00057", "Wntsignaling pathway", "2.59E − 01", "3.07E − 01", "1.00E + 00", "1.00E + 00", "3", "CTNNB1, TP53, SMAD5"], ["P00056", "VEGF signaling pathway", "2.86E − 01", "3.27E − 01", "1.00E + 00", "1.00E + 00", "1", "HRAS"], ["Pathway Ontology"], ["PW:0000125", "G protein signaling", "5.82E − 03", "3.10E − 02", "1.26E − 01", "1.86E − 01", "1", "LTB4R"], ["PW:0000297", "platelet-derived growth factor signaling", "5.82E − 03", "3.10E − 02", "1.26E − 01", "1.86E − 01", "1", "JAK2"], ["PW:0000143", "insulin signaling", "1.05E − 02", "3.36E − 02", "1.36E − 01", "3.37E − 01", "2", "SOCS1, STAT5B"], ["PW:0000330", "Bone morphogenetic proteins signaling", "2.86E − 02", "6.53E − 02", "2.65E − 01", "9.15E − 01", "1", "SMAD5"], ["PW:0000599", "altered canonical Wntsignaling", "2.86E − 02", "6.53E − 02", "2.65E − 01", "9.15E − 01", "1", "CTNNB1"], ["PW:0000508", "platelet aggregation", "3.42E − 02", "6.84E − 02", "2.78E − 01", "1.00E + 00", "1", "GP1BB"], ["PW:0000234", "innate immune response", "6.18E − 02", "1.10E − 01", "4.46E − 01", "1.00E + 00", "1", "TLR2"], ["PW:0000278", "autophagy", "1.04E − 01", "1.39E − 01", "5.65E − 01", "1.00E + 00", "1", "ATG10"], ["PW:0000243", "vascular endothelial growth factor signaling", "1.30E − 01", "1.49E − 01", "6.03E − 01", "1.00E + 00", "1", "FYN"], ["PW:0000490", "transforming growth factor-beta Smad dependent signaling", "1.40E − 01", "1.55E − 01", "6.28E − 01", "1.00E + 00", "1", "RUNX1"], ["SMPDB"], ["SMP00320", "Intracellular Signalling Through Adenosine Receptor A2a and Adenosine", "1.55E − 02", "2.46E − 02", "4.52E − 02", "4.65E − 02", "2", "HRAS, IKBKB"], ["SMP00391", "Insulin Signalling", "1.89E − 01", "1.89E − 01", "3.46E − 01", "5.66E − 01", "1", "HRAS"]], "row_count": 73, "column_count": 8, "numeric_cells": 420, "header_rows": 2, "locator": "section[13]/table-wrap[1]#Tab2"}}, {"id": "asset:table:pmid:33251083:11", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:307d19ecb0dfe452f834715a6c814a8c922a41eba5ff771952acf5734e1660b5", "bytes": 17321, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[13]/table-wrap[2]#Tab3", "version": null, "note": "The enriched pathway terms of the down regulated differentially expressed genes", "structure": {"pmcid": "PMC7679428", "section_index": 13, "section_title": "Pathway enrichment analysis for DEGs", "row_count": 91, "column_count": 8}, "table": {"label": "Table 3", "caption": "The enriched pathway terms of the down regulated differentially expressed genes", "rows": [["BIOCYC", "", "", "", "", "", "", ""], ["Pathway ID", "Pathway Name", "P-value", "FDR B&H", "FDR B&Y", "Bonferroni", "Gene Count", "Gene"], ["703092", "Citrulline-nitric oxide cycle", "8.83E − 02", "2.53E − 01", "8.24E − 01", "1.00E + 00", "1", "NOS2"], ["142419", "Phospholipases", "9.82E − 02", "2.53E − 01", "8.24E − 01", "1.00E + 00", "1", "PLA2G2E, PLA2G2A"], ["545273", "Glycoaminoglycan-protein linkage region biosynthesis", "1.05E − 01", "2.53E − 01", "8.24E − 01", "1.00E + 00", "1", "B3GAT1"], ["545323", "Urate biosynthesis/inosine 5′-phosphate degradation", "1.05E − 01", "2.53E − 01", "8.24E − 01", "1.00E + 00", "1", "NT5E"], ["142383", "Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde", "1.21E − 01", "2.53E − 01", "8.24E − 01", "1.00E + 00", "1", "IDO1"], ["KEGG", "", "", "", "", "", "", ""], ["83051", "Cytokine-cytokine receptor interaction", "3.05E − 61", "5.54E − 59", "3.21E − 58", "5.54E − 59", "69", "IL10, IL10RA, IL12A, IL12B, IL13, IL13RA1, TNFRSF9, IL17A, PDGFB, TNFSF12, IL17B, TNFRSF14, TNFRSF10C, CCL26,IL17F, TNFRSF4, IL22RA2, IL21, CCL7, CCR6, CCL11, CCL13, CCR8, CCL15, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, KIT, CX3CL1, CXCL12, IL19, CCR10, XCR1, CXCL13, PPBP, IL23A, IFNA2, IFNAR1, IFNB1, IFNG, TGFBR1, LIF, CSF1R, CSF2, CSF2RB, CSF3R, IL20, IL22,, CD40, TNFRSF13C, LTA, IL1RAP, IL2, IL3, IL4, IL4R, IL5, IL6, IL6R, IL7, IL26, CXCR1, IL9, CXCR2"], ["83078", "Hematopoietic cell lineage", "4.22E − 35", "3.84E − 33", "2.22E − 32", "7.67E − 33", "34", "HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, CD55, MME, KIT, CR2, TFRC, CD1A, CD3E, CSF1R, CSF2, CD8A, CD9, CSF3R, CD19, MS4A1, CD22, CD34, CD44, CD59, IL3, IL4, IL4R, IL5, IL6, IL6R, IL7"], ["842771", "Inflammatory bowel disease (IBD)", "4.58E − 32", "2.78E − 30", "1.61E − 29", "8.34E − 30", "28", "IL10, IL12A, IL12B, IL13, IL17A, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, GATA3, IL17F, STAT6, IL21, RELA, IL23A, IFNG, IL22, RORC, IL2, IL4, IL4R, IL5, IL6"], ["83077", "Jak-STAT signaling pathway", "4.56E − 26", "1.19E − 24", "6.86E − 24", "8.30E − 24", "33", "IL10, IL10RA, IL12A, IL12B, IL13, IL13RA1, BCL2, STAT5A, STAT6, PTPN6, IL22RA2, IL21, IL19, IL23A, IFNA2, IFNAR1, IFNB1, IFNG, LIF, CSF2, CSF2RB, CSF3R, IL20, IL22, IL2, IL3, IL4, IL4R, IL5, IL6, IL6R, IL7, IL9"], ["213780", "Tuberculosis", "3.41E − 25", "6.89E − 24", "3.99E − 23", "6.20E − 23", "34", "IL10, IL10RA, IL12A, IL12B, CEBPB, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, BCL2, CD209, BID, FCGR2A, FCGR2B, CARD9, NOS2, CASP3, RELA, TLR9, IL23A, IFNA2, IFNB1, IFNG, TIRAP, IRAK4, CD74, MAPK11, CTSS, IL6"], ["83120", "Asthma", "4.56E − 24", "8.30E − 23", "4.80E − 22", "8.30E − 22", "18", "IL10, IL13, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, FCER1A, CCL11, CD40, IL3, IL4, IL5, IL9"], ["125138", "Viral myocarditis", "2.26E − 16", "2.06E − 15", "1.19E − 14", "4.12E − 14", "17", "HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, CD55, BID, CASP3, CD80, CD86, CD40"], ["373901", "HTLV-I infection", "2.85E − 15", "2.35E − 14", "1.36E − 13", "5.18E − 13", "29", "HLA-B, PDGFB, HLA-C, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, ETS1, STAT5A, VCAM1, RELA, RELB, LCK, SLC2A1, TGFBR1, CD3E, CSF2, EGR1, EGR2, CD40, TNFRSF13C, LTA, IL2, IL6"], ["213306", "Measles", "4.04E − 12", "2.53E − 11", "1.47E − 10", "7.35E − 10", "19", "IL12A, IL12B, IL13, CD46, TNFRSF10C, CD209, STAT5A, FCGR2B, RELA, TLR9, IFNA2, IFNAR1, IFNB1, IFNG, CD3E, IRAK4, IL2, IL4, IL6"], ["83074", "Antigen processing and presentation", "7.12E − 12", "4.32E − 11", "2.50E − 10", "1.30E − 09", "15", "HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, IFNG, CD8A, CD74, CTSS"], ["217173", "Influenza A", "4.98E − 11", "2.75E − 10", "1.59E − 09", "9.07E − 09", "20", "IL12A, IL12B, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1,HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, TNFRSF10C, RELA, IFNA2, IFNAR1, IFNB1, IFNG, IRAK4, MAPK11, IL6"], ["Pathway interaction database", "", "", "", "", "", "", ""], ["137933", "IL4-mediated signaling events", "7.74E − 16", "8.36E − 14", "4.40E − 13", "8.36E − 14", "17", "IL10, IL13RA1, CEBPB, AICDA, ETS1, CCL26, STAT5A, STAT6, PTPN6, PIGR, CCL11, THY1, EGR2, LTA, IL4, IL4R, IL5"], ["137922", "IL12-mediated signaling events", "9.23E − 15", "4.99E − 13", "2.62E − 12", "9.97E − 13", "16", "IL12A, IL12B, HLA-DRA, HLA-DRB1, STAT5A, STAT6, EOMES, NOS2, RELA, RELB, LCK, IFNG, CD3E, CD8A, IL2, IL4"], ["138000", "IL23-mediated signaling events", "1.32E − 12", "4.75E − 11", "2.50E − 10", "1.42E − 10", "12", "IL12B, IL17A, IL17F, STAT5A, NOS2, IL19, RELA, IL23A, IFNG, CD3E, IL2, IL6"], ["137929", "IL27-mediated signaling events", "1.43E − 11", "3.87E − 10", "2.04E − 09", "1.55E − 09", "10", "IL12A, IL12B, IL17A, GATA3, STAT5A, IFNG, EBI3, IL2, IL6, IL27"], ["138058", "BCR signaling pathway", "3.00E − 07", "4.05E − 06", "2.13E − 05", "3.24E − 05", "10", "ETS1, PTPN6, FCGR2B, BTK, POU2F2, RELA, CD19, CD22, CD79A, CD79B"], ["138055", "TCR signaling in naive CD8 + T cells", "2.28E − 04", "1.30E − 03", "6.82E − 03", "2.46E − 02", "6", "PTPN6, LCK, CD3E, CD8A, CD80, CD86"], ["137939", "Direct p53 effectors", "2.95E − 03", "1.33E − 02", "7.00E − 02", "3.18E − 01", "8", "SPP1, BCL2, TNFRSF10C, BID, CD82, MAP4K4, CX3CL1, LIF"], ["138081", "FAS (CD95) signaling pathway", "3.67E − 03", "1.42E − 02", "7.46E − 02", "3.97E − 01", "4", "BID, BTK, CASP3, MAPK11"], ["137995", "HIV-1 Nef: Negative effector of Fas and TNF-alpha", "3.67E − 03", "1.42E − 02", "7.46E − 02", "3.97E − 01", "4", "BCL2, BID, CASP3, RELA"], ["137944", "IL1-mediated signaling events", "2.58E − 02", "6.45E − 02", "3.40E − 01", "1.00E + 00", "3", "TOLLIP, RELA, IRAK4"], ["REACTOME", "", "", "", "", "", "", ""], ["1269310", "Cytokine Signaling in Immune system", "3.81E − 46", "2.02E − 43", "1.39E − 42", "2.02E − 43", "86", "IL10, IL10RA, IL12A, IL12B, IL13, IL13RA1, IL16, TRAF3, TNFRSF9, IL17A, HLA-B, PDGFB, HLA-C, TNFSF12, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, TNFRSF14, GATA3, PSMB10, BCL2, PTAFR, IL1RL2, IL17F, PTK2, STAT5A, STAT6, TNFRSF4, PTPN6, IL22RA2, TOLLIP, CCL11, CCL19, CCL20, CCL22, KIT, NOS2, VCAM1, IL19, RAG1, RAG2, ZEB1, FN1, DUSP4, IRF8, CASP3, RELA, RELB, LCK, IL23A, S1PR1, IFNA2, IFNAR1, IFNB1, IFNG, LIF, CSF1R, CSF2, CSF2RB, CSF3R, EBI3, EGR1, IL20, CD80, CD86, IL22, CD40, IRAK4, CD44, TNFRSF13C, LTA, RORC, IL1RAP, IL2, IL3, IL4, IL4R, IL5, IL6, IL6R, IL7, IL27, IL9"], ["1269318", "Signaling by Interleukins", "2.98E − 33", "7.91E − 31", "5.42E − 30", "1.58E − 30", "62", "IL10, IL10RA, IL12A, IL12B, IL13, IL13RA1, IL16, IL17A, PDGFB, GATA3, PSMB10, BCL2, PTAFR, IL1RL2, IL17F, PTK2, STAT5A, STAT6, PTPN6, IL22RA2, TOLLIP, CCL11, CCL19, CCL20, CCL22, KIT,NOS2, VCAM1, IL19, RAG1, RAG2, ZEB1, FN1, DUSP4, CASP3, RELA, LCK, IL23A, S1PR1, LIF, CSF1R, CSF2, CSF2RB, CSF3R, EBI3, IL20, CD80, CD86, IL22, IRAK4, RORC, IL1RAP, IL2, IL3, IL4, IL4R, IL5, IL6, IL6R,IL7, IL27, IL9"], ["1269203", "Innate Immune System", "4.93E − 25", "8.72E − 23", "5.98E − 22", "2.62E − 22", "82", "MASP1, TRAF3, HLA-B, PDGFB, HLA-C, MAPKAPK2, CTSC, PECAM1, MBL2, PSMB10, CD55, CD46, BCL2, DEFB103B, PTAFR, CD209, PTK2, STAT6, DEFB1, DEFB4A, CFD, PTPN6, FCAR, FCER1A, PIGR, FCGR2A, CARD9, BTK, MIF, PLA2G2A, TOLLIP, C1R, C1S, C4A, PLAU, C4BPA, CCR6, MME, C6, C7, C8A, C8B, C9, KIT, NOS2, GPI, LILRA3, VTN, CLEC6A, FN1, ATG7, ITLN1, DUSP4, ICAM2, ICAM3, RELA, RELB, TLR9, LCK, PPBP, CFI, IFNA2, LGALS3, IFNB1, CSF2, CSF2RB, CD19, SIGIRR, CD80, CD86, TIRAP, IRAK4, CD44, CD59, MAPK11, IL2, IL3, IL5, CTSS, CXCR1, MASP2, CXCR2"], ["1269171", "Adaptive Immune System", "1.51E − 15", "1.15E − 13", "7.86E − 13", "8.03E − 13", "52", "HLA-B, PDGFB, HLA-C, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, CTSC, HLA-DRB1, TNFRSF14, PSMB10, PTPN22, CD209, PTPN6, SLAMF6, FCGR2B, BTK, KIT, KLRB1, LILRB5, VCAM1, ICOSLG, LILRA1, LILRA3, LILRA2, ATG7, ICAM2, ICAM3, ICAM4, RELA, BTLA, LCK, CD1A, CD3E, CD8A, CD19, CD22, CD80, CD86, ICAM5, TIRAP, CD34, CD40, CD74, CD79A, CD79B, CTLA4, CTSS"], ["1269201", "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "5.01E − 14", "2.66E − 12", "1.82E − 11", "2.66E − 11", "21", "HLA-B, HLA-C, SLAMF6, FCGR2B, KLRB1, LILRB5, VCAM1, LILRA1, LILRA3, LILRA2, ICAM2, ICAM3, ICAM4, CD1A, CD3E, CD8A, CD19, CD22, ICAM5, CD34, CD40"], ["1269546", "Peptide ligand-binding receptors", "6.17E − 08", "1.82E − 06", "1.25E − 05", "3.27E − 05", "17", "CCR6, CCL13, CCR8, CCL16, CCL19, CCL20, CXCL11, XCL1, CX3CL1, CXCL12, CCR10, XCR1, CXCL13, PPBP, EDNRB, CXCR1, CXCR2"], ["1269545", "Class A/1 (Rhodopsin-like receptors)", "4.71E − 07", "1.14E − 05", "7.79E − 05", "2.50E − 04", "21", "PTAFR, PTGER4, CCR6, CCL13,CCR8,CCL16, CCL19, CCL20, CXCL11, XCL1, CX3CL1, CXCL12, CCR10, XCR1, CXCL13, GPR183, PPBP, S1PR1, EDNRB, CXCR1, CXCR2"], ["1269340", "Hemostasis", "1.15E − 04", "1.47E − 03", "1.01E − 02", "6.09E − 02", "26", "CD244, PDGFB, PECAM1, GATA3, PTK2, CFD, PTPN6, MIF, PLAU, NOS2, SELE, SELPLG, FN1, LCK, PPBP, IFNA2, IFNB1, CSF2, CSF2RB, CD9, CD44, CD48, CD74, IL2, IL3, IL5"], ["1269501", "MAPK family signaling cascades", "3.27E − 04", "3.40E − 03", "2.33E − 02", "1.74E − 01", "15", "PDGFB, PSMB10, PTK2, KIT, RAG1, RAG2, FN1, DUSP4, CSF2, CSF2RB, IL2, IL3, IL5, IL6, IL6R"], ["1269240", "Toll Like Receptor TLR6:TLR2 Cascade", "3.46E − 04", "3.40E − 03", "2.33E − 02", "1.84E − 01", "8", "MAPKAPK2, BTK, DUSP4, RELA, SIGIRR, TIRAP, IRAK4, MAPK11"], ["Gen MAPP", "", "", "", "", "", "", ""], ["MAP00400", "Phenylalanine tyrosine and tryptophan biosynthesis", "1.38E − 01", "5.02E − 01", "1.00E + 00", "1.00E + 00", "1", "BID"], ["MAP_kinase_activity", "MAP kinase activity", "1.38E − 01", "5.02E − 01", "1.00E + 00", "1.00E + 00", "1", "MAPK11"], ["MAP00010", "Glycolysis Gluconeogenesis", "2.47E − 01", "5.02E − 01", "1.00E + 00", "1.00E + 00", "2", "BID, GPI"], ["MAP00030", "Pentose phosphate", "2.70E − 01", "5.02E − 01", "1.00E + 00", "1.00E + 00", "1", "GPI"], ["MAP00590", "Prostaglandin and leukotriene metabolism", "2.96E − 01", "5.02E − 01", "1.00E + 00", "1.00E + 00", "1", "PLA2G2A"], ["MAP00500", "Starch and sucrose metabolism", "3.34E − 01", "5.02E − 01", "1.00E + 00", "1.00E + 00", "1", "GPI"], ["MAP00330", "Arginine and proline metabolism", "5.05E − 01", "5.81E − 01", "1.00E + 00", "1.00E + 00", "1", "NOS2"], ["MAP00380", "Tryptophan metabolism", "5.73E − 01", "5.81E − 01", "1.00E + 00", "1.00E + 00", "1", "IDO1"], ["MAP00561", "Glycerolipid metabolism", "5.81E − 01", "5.81E − 01", "1.00E + 00", "1.00E + 00", "1", "PLA2G2A"], ["MSigDB C2 BIOCARTA (v6.0)", "", "", "", "", "", "", ""], ["M5883", "Genes encoding secreted soluble factors", "4.86E − 27", "7.82E − 25", "4.43E − 24", "7.82E − 25", "46", "IL10, IL12A, IL12B, IL13, IL16, IL17A, PDGFB, TNFSF12, IL17B, CCL26, IL17F, CCL7, CCL11, CCL13, CCL15, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, CX3CL1, CXCL12, IL19, CXCL13, PPBP, IL23A, IFNA2, IFNB1, IFNG, LIF, CSF2, EBI3, IL20, IL22, LTA, IL2, IL3, IL4, IL5, IL6, IL7, IL26, IL9"], ["M17406", "Cytokine Network", "2.71E − 22", "2.18E − 20", "1.24E − 19", "4.36E − 20", "15", "IL10, IL12A, IL12B, IL13, IL16, IL17A, IFNB1, IFNG, LTA, IL2, IL3, IL4, IL5, IL6, IL9"], ["M6910", "Cytokines and Inflammatory Response", "5.19E − 21", "2.78E − 19", "1.58E − 18", "8.35E − 19", "16", "IL10, IL12A, IL12B, IL13, HLA-DRA, HLA-DRB1, IFNB1, IFNG, CSF2, LTA, IL2, IL3, IL4, IL5, IL6, IL7"], ["M5885", "Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors", "7.80E − 21", "3.14E − 19", "1.78E − 18", "1.26E − 18", "57", "IL10, IL12A, IL12B, IL13, MASP1, IL16, IL17A, PDGFB, TNFSF12, CTSC, IL17B, MBL2, CCL26, IL17F, CD209, PLAU, CCL7, CCL11, CCL13, CCL15, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, CX3CL1, CXCL12, IL19, CLEC6A, ITLN1, CXCL13, ITLN2, PPBP, IL23A, IFNA2, LGALS3, IFNB1, IFNG, LIF, CSF2, EBI3, IL20, IL22, LTA, IL2, IL3, IL4, IL5, CTSS, IL6, IL7, IL26, IL9, MASP2"], ["M5889", "Ensemble of genes encoding extracellular matrix and extracellular matrix-associated proteins", "4.62E − 17", "1.49E − 15", "8.43E − 15", "7.44E − 15", "61", "IL10, IL12A, IL12B, IL13, MASP1, IL16, IL17A, PDGFB, TNFSF12, SPP1, CTSC,IL17B, MBL2, CCL26, IL17F, CD209, PLAU, CCL7,CCL11, CCL13, CCL15,CCL16, CCL18, CCL19, CCL20,CCL22, CCL24, CXCL11,XCL1, CX3CL1, CXCL12, IL19, VTN,CLEC6A, FN1, ITLN1, CXCL13,ITLN2, PPBP, IL23A,IFNA2, LGALS3, IFNB1, IFNG, TGFBI, LIF, CSF2, EBI3, IL20, IL22, LTA, IL2, IL3, IL4, IL5, CTSS, IL6, IL7, IL26, IL9, MASP2"], ["M1467", "The Co-Stimulatory Signal During T-cell Activation", "4.81E − 11", "7.03E − 10", "3.98E − 09", "7.74E − 09", "9", "HLA-DRA, HLA-DRB1, ICOSLG, LCK, CD3E, CD80, CD86, CTLA4, IL2"], ["M3952", "Cells and Molecules involved in local acute inflammatory response", "1.02E − 05", "7.46E − 05", "4.22E − 04", "1.64E − 03", "5", "C6, C7, VCAM1, SELPLG,IL6"], ["M18215", "Role of Tob in T-cell activation", "3.16E − 05", "2.21E − 04", "1.25E − 03", "5.08E − 03", "5", "IFNG, TGFBR1, CD3E, IL2, IL4"], ["M13968", "HIV-I Nef: negative effector of Fas and TNF", "6.46E − 04", "3.15E − 03", "1.78E − 02", "1.04E − 01", "6", "BCL2,PTK2, BID, CASP3, RELA, ARHGDIB"], ["M13247", "T Cytotoxic Cell Surface Molecules", "1.90E − 03", "6.80E − 03", "3.85E − 02", "3.06E − 01", "3", "CD3E, CD8A, THY1"], ["Panther DB", "", "", "", "", "", "", ""], ["P00036", "Interleukin signaling pathway", "6.51E − 19", "2.47E − 17", "1.05E − 16", "2.47E − 17", "22", "IL10,IL10RA, IL12A,IL13, IL13RA1, IL17A, MAPKAPK2, IL17F, STAT5A, STAT6, IL21, IL23A, IL2, IL4, IL4R, IL5, IL6, IL6R, IL7, CXCR1, IL9, CXCR2"], ["P00031", "Inflammation mediated by chemokine and cytokine signaling pathway", "4.36E − 07", "8.28E − 06", "3.50E − 05", "1.66E − 05", "16", "CCL26, CCL7, CCR6, CCL11, CCL13, CCR8, CCL18, CCL20, CCL22, CX3CL1, CCR10, XCR1, IFNAR1, IFNG, CXCR1, CXCR2"], ["P00053", "T cell activation", "7.23E − 05", "8.13E − 04", "3.44E − 03", "2.75E − 03", "8", "HLA-DPA1, HLA-DQA1, HLA-DRA, LCK, CD3E, CD80, CD86, CD74"], ["P00010", "B cell activation", "8.56E − 05", "8.13E − 04", "3.44E − 03", "3.25E − 03", "7", "PTPN6, BTK, CD19, CD22, CD79A, CD79B, MAPK11"], ["P00054", "Toll receptor signaling pathway", "2.14E − 03", "1.62E − 02", "6.86E − 02", "8.12E − 02", "5", "TOLLIP, RELA, TLR9, IFNB1, IRAK4"], ["P00006", "Apoptosis signaling pathway", "2.67E − 03", "1.69E − 02", "7.14E − 02", "1.01E − 01", "7", "BCL2, BID, BCL2L11, CASP3, RELA, RELB, LTA"], ["P00035", "Interferon-gamma signalingpathway", "1.42E − 02", "7.69E − 02", "3.25E − 01", "5.39E − 01", "3", "PTPN6, IFNG, MAPK11"], ["P00046", "Oxidative stress response", "5.17E − 02", "1.86E − 01", "7.88E − 01", "1.00E + 00", "3", "BCL2, DUSP4, MAPK11"], ["P00047", "PDGF signaling pathway", "8.39E − 02", "2.44E − 01", "1.00E + 00", "1.00E + 00", "5", "PDGFB, MAPKAPK2, ETS1, STAT5A, STAT6"], ["P00034", "Integrin signalling pathway", "5.94E − 01", "7.28E − 01", "1.00E + 00", "1.00E + 00", "3", "ITGAE, PTK2, FN1"], ["Pathway Ontology", "", "", "", "", "", "", ""], ["PW:0000104", "intrinsic apoptotic", "1.82E − 03", "7.63E − 02", "3.30E − 01", "7.63E − 02", "4", "BCL2, BID, BCL2L11, CASP3"], ["PW:0000515", "Interleukin-10 signaling", "7.84E − 01", "1.57E − 01", "6.78E − 01", "6.78E − 01", "1", "IL10"], ["PW:0000516", "Interleukin-6 signaling", "7.84E − 01", "1.57E − 01", "6.78E − 01", "6.78E − 01", "1", "IL6"], ["PW:0000499", "Nuclear Factor Kappa B signaling", "9.58E − 01", "1.60E − 01", "6.91E − 01", "6.91E − 01", "2", "RELA, RELB"], ["PW:0000009", "programmed cell death", "1.00E + 00", "1.80E − 01", "7.78E − 01", "7.78E − 01", "2", "BCL2, CASP3"], ["PW:0000102", "The extracellular signal-regulated RAF/MEK/ERK signaling", "8.14E − 02", "2.18E − 01", "9.44E − 01", "1.00E + 00", "2", "SPP1, S1PR1"], ["PW:0000529", "angiotensin (1-7) signaling", "8.83E − 02", "2.18E − 01", "9.44E − 01", "1.00E + 00", "1", "MME"], ["PW:0000106", "extrinsic apoptotic", "1.05E − 01", "2.45E − 01", "1.00E + 00", "1.00E + 00", "1", "CASP3"], ["PW:0000559", "hexosamine biosynthetic", "1.21E − 01", "2.55E − 01", "1.00E + 00", "1.00E + 00", "1", "GPI"], ["PW:0000228", "G protein signaling via Galphai family", "1.53E − 01", "2.80E − 01", "1.00E + 00", "1.00E + 00", "1", "S1PR1"], ["SMPDB", "", "", "", "", "", "", ""], ["SMP00094", "Sulindac Pathway", "1.21E − 01", "4.52E − 01", "1.00E + 00", "1.00E + 00", "1", "PLA2G2A"], ["SMP00040", "Glycolysis", "2.14E − 01", "4.52E − 01", "1.00E + 00", "1.00E + 00", "1", "GPI"], ["SMP00063", "Tryptophan Metabolism", "2.70E − 01", "4.52E − 01", "1.00E + 00", "1.00E + 00", "1", "IDO1"], ["SMP00379", "NifedipinePathway", "2.83E − 01", "4.52E − 01", "1.00E + 00", "1.00E + 00", "1", "EDNRB"], ["SMP00006", "Tyrosine Metabolism", "3.59E − 01", "4.84E − 01", "1.00E + 00", "1.00E + 00", "1", "MIF"], ["SMP00320", "Intracellular Signalling Through Adenosine Receptor A2a and Adenosine", "4.57E − 01", "4.84E − 01", "1.00E + 00", "1.00E + 00", "1", "MAPK11"]], "row_count": 91, "column_count": 8, "numeric_cells": 544, "header_rows": 2, "locator": "section[13]/table-wrap[2]#Tab3"}}, {"id": "asset:table:pmid:33251083:12", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:3d0cc2025b76ce360a2ebcd6f7a40ea02ca2add666d309680d150a2f033eabd0", "bytes": 8645, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[14]/table-wrap[1]#Tab4", "version": null, "note": "The enriched GO terms of the up regulated differentially expressed genes", "structure": {"pmcid": "PMC7679428", "section_index": 14, "section_title": "Gene ontology (GO) enrichment analysis for DEGs", "row_count": 31, "column_count": 9}, "table": {"label": "Table 4", "caption": "The enriched GO terms of the up regulated differentially expressed genes", "rows": [["GO ID", "CATEGORY", "GO Name", "P Value", "FDR B&H", "FDR B&Y", "Bonferroni", "Gene Count", "Gene"], ["GO:0002682", "BP", "Regulation of immune system process", "1.53E − 44", "5.68E − 41", "5.00E − 40", "5.68E − 41", "56", "KLRK1, ATG5, JAK1, JAK2, IFIH1, PDCD1, TRAF2, TRAF6, IKZF3, CD247, ZBTB16, ABL1, HLA-A, IKBKE, CD99, BST2, LILRB2, TBX21, TLR2, LAG3, HRAS, PSMB9, C1QBP, CLEC7A, SERPING1, XBP1, GBP1, SOCS1, C2, CCR1, IKZF1, CCL5, IRF7, CTNNB1, RUNX1, SLAMF7, IKBKB, LCP2, ITGAL, FYN, IL18RAP, ITGB2, IL2RG, IL18R1, KLRC1, ZAP70, GFI1, KLRD1, CX3CR1, STAT1, TP53, NLRP3, STAT3, STAT5B, CEACAM1, IFNAR2"], ["GO:0009607", "BP", "Response to biotic stimulus", "6.86E − 35", "6.36E − 32", "5.59E − 31", "2.54E − 31", "48", "KLRK1, ATG5, JAK1, JAK2, IFIH1, TRAF6, IKZF3, ATG10, ABL1, HLA-A, IKBKE, BST2, LILRB2, TBX21, TLR2, GZMB, LAG3, HRAS, PSMB9, C1QBP, CLEC7A, SERPING1, XBP1, GBP1, SOCS1, C2, IRF5, CCL5, IRF7, CCR5, GNLY, SLAMF7, IKBKB, FYN, IFI35, IL18RAP, ITGB2, MAP4K2, GFI1, KLRD1, CX3CR1, STAT1, TP53, NLRP3, MX1, STAT5B, CEACAM1, IFNAR2"], ["GO:0006952", "BP", "Defense response", "1.12E − 33", "5.92E − 31", "5.21E − 30", "4.14E − 30", "49", "KLRK1, JAK1, JAK2, IFIH1, TRAF6, HLA-A, IKBKE, BST2, LILRB2, TLR2, GZMB, LAG3, HRAS, PSMB9, C1QBP, CLEC7A, SERPING1, GBP1, CCRL2, SOCS1, C2, CCR1, IRF5, CCL5, IRF7, CCR5, GNLY, LTB4R, SLAMF7, IKBKB, ITGAL, FYN, IFI35, IL18RAP, ITGB2, IL18R1, MAP4K2, GFI1, KLRD1, CX3CR1, STAT1, TP53, NLRP3, STAT3, STAT4, MX1, STAT5B, CEACAM1, IFNAR2"], ["GO:0001816", "BP", "Cytokine production", "3.84E − 27", "1.29E − 24", "1.14E − 23", "1.42E − 23", "34", "KLRK1, ATG5, JAK2, IFIH1, TRAF2, TRAF6, CD247, ABL1, IKBKE, BST2, LILRB2, TBX21, TLR2, LAG3, HRAS, C1QBP, CLEC7A, XBP1, GBP1, SOCS1, IRF5, CCL5, IRF7, CTNNB1, RUNX1, LCP2, IL18RAP, IL18R1, CX3CR1, STAT1, NLRP3, STAT3, STAT5B, CEACAM1"], ["GO:0034097", "BP", "Response to cytokine", "2.23E − 26", "6.90E − 24", "6.07E − 23", "8.28E − 23", "38", "JAK1, JAK2, IFIH1, TRAF2, TRAF6, HLA-A, IKBKE, BST2, TLR2, PSMB9, XBP1, GBP1, CCRL2, SOCS1, CCR1, IRF5, CCL5, IRF7, CCR5, CTNNB1, RUNX1, IKBKB, FYN, IFI35, IL18RAP, ITGB2, IL2RG, IL18R1, GFI1, CX3CR1, STAT1, TP53, STAT3, STAT4, MX1, STAT5B, CEACAM1, IFNAR2"], ["GO:0042110", "BP", "T cell activation", "1.68E − 25", "4.43E − 23", "3.90E − 22", "6.21E − 22", "28", "CCND3, KLRK1, ATG5, PDCD1, TRAF6, ZBTB16, ABL1, LILRB2, TBX21, LAG3, CLEC7A, XBP1, SOCS1, IKZF1, CCL5, CTNNB1, RUNX1, ITGAL, FYN, ITGB2, IL2RG, IL18R1, ZAP70, TP53, NLRP3, STAT3, STAT5B, CEACAM1"], ["GO:0045321", "BP", "Leukocyte activation", "6.65E − 23", "1.30E − 20", "1.14E − 19", "2.47E − 19", "36", "CCND3, KLRK1, ATG5, JAK2, PDCD1, TRAF6, IKZF3, ZBTB16, ABL1, BST2, LILRB2, TBX21, TLR2, LAG3, CLEC7A, XBP1, SOCS1, IKZF1, CCL5, CTNNB1, RUNX1, SLAMF7, LCP2, ITGAL, FYN, IL18RAP, ITGB2, IL2RG, IL18R1,ZAP70, CX3CR1,TP53, NLRP3, STAT3, STAT5B, CEACAM1"], ["GO:0001775", "BP", "Cell activation", "2.83E − 22", "5.00E − 20", "4.40E − 19", "1.05E − 18", "37", "CCND3, KLRK1, ATG5, JAK2, PDCD1, TRAF6, IKZF3, ZBTB16, ABL1, BST2, LILRB2, TBX21, TLR2, LAG3, CLEC7A, XBP1, SOCS1, IKZF1, CCL5, CTNNB1, RUNX1, SLAMF7, LCP2, ITGAL, FYN, IL18RAP, ITGB2, IL2RG, IL18R1, ZAP70, CX3CR1, TP53, NLRP3, STAT3, STAT5B, CEACAM1, GP1BB"], ["GO:0080134", "BP", "Regulation of response to stress", "3.88E − 18", "3.59E − 16", "3.16E − 15", "1.44E − 14", "34", "KLRK1, JAK1, JAK2, IFIH1, TRAF2, TRAF6, ABL1, IKBKE, MAP4K1, TLR2, LAG3, HRAS, PSMB9, C1QBP, CLEC7A, SERPING1, XBP1, SOCS1, CCL5, IRF7, CTNNB1, IKBKB, FYN, IL18RAP, ITGB2, MAP4K2, GFI1, CX3CR1, STAT1, TP53, NLRP3, STAT5B, CEACAM1, IFNAR2"], ["GO:0051094", "BP", "Positive regulation of developmental process", "1.52E − 15", "1.00E − 13", "8.79E − 13", "5.64E − 12", "31", "JAK1, JAK2, TRAF6, ZBTB16, ABL1, LILRB2, TBX21, TLR2, C1QBP, CLEC7A, XBP1, SOCS1, CCR1, IKZF1, CCL5, CTNNB1, RUNX1, IKBKB, FYN, ITGB2, IL2RG, ZAP70, GFI1, CX3CR1, STAT1, TP53, NLRP3, STAT3, STAT5B, SMAD5, CEACAM1"], ["GO:0098552", "CC", "Side of membrane", "1.17E − 11", "1.54E − 09", "9.47E − 09", "3.08E − 09", "18", "KLRK1, PDCD1, TRAF2, TRAF6, HLA-A, TLR2, LAG3, CCRL2, CCR1, CCR5, SLAMF7, IKBKB, ITGAL, FYN, ITGB2, IL2RG, KLRD1, CX3CR1"], ["GO:0043235", "CC", "Receptor complex", "3.20E − 10", "2.81E − 08", "1.73E − 07", "8.44E − 08", "15", "TRAF2, TRAF6, CD247, TLR2, IKBKB, LCP2, ITGAL, IL18RAP, ITGB2, IL2RG, IL18R1, KLRC1, ZAP70, KLRD1, CEACAM1"], ["GO:0009986", "CC", "Cell surface", "2.20E − 09", "9.68E − 08", "5.96E − 07", "5.81E − 07", "19", "KLRK1, PDCD1, HLA-A, BST2, LILRB2, TLR2, LAG3, C1QBP, CLEC7A, CCRL2, CCR1, CCR5, SLAMF7, ITGAL, ITGB2, IL2RG, KLRD1, CX3CR1, CEACAM1"], ["GO:0005887", "CC", "Integral component of plasma membrane", "2.88E − 07", "6.90E − 06", "4.25E − 05", "7.59E − 05", "21", "KLRK1, TRAF2, TRAF6, CD99, LILRB2, TLR2, CCRL2, CCR1, CCR5, LTB4R, IKBKB, ITGAL, IL18RAP, ITGB2, IL2RG, IL18R1, KLRC1, CX3CR1, CEACAM1, GP1BB, IFNAR2"], ["GO:0098805", "CC", "Whole membrane", "8.24E − 06", "1.55E − 04", "9.56E − 04", "2.18E − 03", "19", "ATG5, JAK2, TRAF2, TRAF6, HLA-A, IKBKE, BST2, LILRB2, TLR2, IRF7, LTB4R, CTNNB1, IKBKB, LCP2, ITGAL, FYN, ITGB2, ZAP70, CEACAM1"], ["GO:0044194", "CC", "cytolytic granule", "1.84E − 04", "2.70E − 03", "1.66E − 02", "4.87E − 02", "2", "GZMB, GNLY"], ["GO:0000790", "CC", "Nuclear chromatin", "9.72E − 04", "1.17E − 02", "7.18E − 02", "2.57E − 01", "16", "IKZF3, ZBTB16, TBX21, XBP1, IRF5, IKZF1, IRF7, CTNNB1, RUNX1, GFI1, STAT1, TP53, STAT3, STAT4, STAT5B, SMAD5"], ["GO:0090575", "CC", "RNA polymerase II transcription factor complex", "5.30E − 03", "4.21E − 02", "2.59E − 01", "1.00E + 00", "4", "CTNNB1, RUNX1, TP53, STAT3"], ["GO:0005667", "CC", "Transcription factor complex", "5.46E − 03", "4.21E − 02", "2.59E − 01", "1.00E + 00", "6", "IKZF1, CTNNB1, RUNX1, TP53, STAT3, SMAD5"], ["GO:0048471", "CC", "Perinuclear region of cytoplasm", "8.69E − 03", "4.78E − 02", "2.94E − 01", "1.00E + 00", "8", "TRAF6, ABL1, HRAS, CTNNB1, FYN, CX3CR1, STAT1, MX1"], ["GO:0019900", "MF", "Kinase binding", "6.20E − 10", "1.90E − 07", "1.27E − 06", "2.82E − 07", "19", "CCND3, KLRK1, JAK2, TRAF2, TRAF6, CD247, ABL1, C1QBP, XBP1, SOCS1, CCL5, CTNNB1, IKBKB, ITGB2, MAP4K2, TP53, STAT3, CEACAM1, IFNAR2"], ["GO:0005102", "MF", "Signaling receptor binding", "7.06E − 08", "3.57E − 06", "2.39E − 05", "3.21E − 05", "23", "KLRK1, JAK1, JAK2, TRAF2, TRAF6, ABL1, HLA-A, LILRB2, TLR2, LAG3, C1QBP, CLEC7A, CCRL2, SOCS1, CCL5, CTNNB1, FYN, ITGB2, KLRD1, STAT1, TP53, STAT3, STAT5B"], ["GO:0044212", "MF", "Transcription regulatory region DNA binding", "1.45E − 07", "5.42E − 06", "3.63E − 05", "6.57E − 05", "17", "TRAF6, IKZF3, ZBTB16, TBX21, XBP1, IRF5, IKZF1, IRF7, CTNNB1, RUNX1, GFI1, STAT1, TP53, STAT3, STAT4, STAT5B, SMAD5"], ["GO:0038023", "MF", "Signaling receptor activity", "3.46E − 07", "1.13E − 05", "7.54E − 05", "1.58E − 04", "21", "KLRK1, CD247, LILRB2, TLR2, LAG3, CLEC7A, CCRL2, CCR1, CCL5, CCR5, LTB4R, ITGAL, IL18RAP, ITGB2, IL2RG, IL18R1, KLRC1, KLRD1, CX3CR1, GP1BB, IFNAR2"], ["GO:0043565", "MF", "Sequence-specific double-stranded DNA binding", "5.76E − 06", "9.35E − 05", "6.27E − 04", "2.62E − 03", "16", "IKZF3, ZBTB16, ABL1, TBX21, XBP1, IRF5, IKZF1, IRF7, RUNX1, STAT1, TP53, NLRP3, STAT3, STAT4, STAT5B, SMAD5"], ["GO:0016772", "MF", "Transferase activity, transferring phosphorus-containing groups", "8.11E − 06", "1.19E − 04", "7.98E − 04", "3.69E − 03", "20", "CCND3, JAK1, JAK2, TRAF2, TRAF6, ABL1, IKBKE, MAP4K1, HRAS, SOCS1, CCL5, CTNNB1, IKBKB, LCP2, FYN, ZAP70, MAP4K2, TP53, STAT3, CEACAM1"], ["GO:0070011", "MF", "Peptidase activity, acting on L-amino acid peptides", "1.03E − 05", "1.38E − 04", "9.27E − 04", "4.66E − 03", "16", "ATG5, JAK2, IFIH1, TRAF2, TRAF6, BST2, GZMB, PSMB9, CLEC7A, SERPING1, C2, FYN, STAT1, TP53, NLRP3, STAT3"], ["GO:0000977", "MF", "RNA polymerase II regulatory region sequence-specific DNA binding", "1.25E − 05", "1.58E − 04", "1.06E − 03", "5.67E − 03", "13", "IKZF3, ZBTB16, TBX21, XBP1, IKZF1, IRF7, RUNX1, STAT1, TP53, STAT3, STAT4, STAT5B, SMAD5"], ["GO:0035639", "MF", "Purine ribonucleoside triphosphate binding", "3.00E − 04", "1.75E − 03", "1.17E − 02", "1.37E − 01", "17", "JAK1, JAK2, IFIH1, ABL1, IKBKE, MAP4K1, HRAS, CUL9, GBP1, RUNX1, IKBKB, FYN, ZAP70, MAP4K2, TP53, NLRP3, MX1"], ["GO:0032559", "MF", "Adenylribonucleotide binding", "1.44E − 03", "6.51E − 03", "4.36E − 02", "6.57E − 01", "14", "JAK1, JAK2, IFIH1, ABL1, IKBKE, MAP4K1, CUL9, RUNX1, IKBKB, FYN, ZAP70, MAP4K2, TP53, NLRP3"]], "row_count": 31, "column_count": 9, "numeric_cells": 206, "header_rows": 1, "locator": "section[14]/table-wrap[1]#Tab4"}}, {"id": "asset:table:pmid:33251083:13", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:9ea3fe1ecbcc8d1365fe22b90c78b557792dba52572caca21621e8b502cab796", "bytes": 17310, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[14]/table-wrap[2]#Tab5", "version": null, "note": "The enriched GO terms of the down regulated differentially expressed genes", "structure": {"pmcid": "PMC7679428", "section_index": 14, "section_title": "Gene ontology (GO) enrichment analysis for DEGs", "row_count": 32, "column_count": 9}, "table": {"label": "Table 5", "caption": "The enriched GO terms of the down regulated differentially expressed genes", "rows": [["GO ID", "Category", "GO Name", "P Value", "FDR B&H", "FDR B&Y", "Bonferroni", "Gene Count", "Gene"], ["GO:0002682", "BP", "Regulation of immune system process", "1.87E − 103", "9.66E − 100", "8.82E − 99", "9.66E − 100", "153", "IL10, IL12A, IL12B, IL13, IRGM, MASP1, TRAF3, IL17A, CEBPB, CD244, HLA-B, HLA-C, IDO1, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, MAPKAPK2, HLA-DQB1, HLA-DRA, CTSC, HLA-DRB1, PECAM1, MBL2, TNFRSF14, GATA3, ETS1, PSMB10, CD55, PTPN22, CD46, BCL2, PTAFR, CD83, PTGER4, IL1RL2, CD209, PTK2, STAT5A, STAT6, TNFRSF4, CFD, PTPN6, SLAMF6, FCER1A, PIGR, FCGR2A, FCGR2B, CARD9, BTK, MIF, IL21, C1R, C1S, C4A, C4BPA, CCL7, CCR6, C6, C7, C8A, CCL19, C8B, CCL20, C9, CCL24, TAL1, XCL1, KIT, CX3CL1, KLRB1, CXCL12, VCAM1, SELE, GPI, RAG1, DPP4, ICOSLG, LILRA1, LILRA2, ZEB1, VTN, CLEC6A, ATG7, ICAM2, ICAM3, ICAM4, CXCL13, CASP3, AIRE, RELA, BTLA, RELB, GPR183, TLR9, LCK, CFI, CR2, IL23A, IFNA2, LGALS3, TFRC,IFNB1, IFNG, LIF, CD1A, CD3E, CSF1R, CSF2, CD8A, THY1, CD9, CSF3R, CD19, TIGIT, MS4A1, EBI3, CD22, IL20, CD80, CD86, ICAM5, TIRAP, CD34, CD40, IRAK4, CD44, CD48, TNFRSF13C, CD59, CD74, CD79A, CD79B, LTA, RORC, CTLA4, PAX5, HAMP, MAPK11, IL2, IL3, IL4, IL4R, IL5, CTSS, IL6, IL6R, IL7, IL27, MASP2, CXCR2"], ["GO:0019221", "BP", "Cytokine-mediated signaling pathway", "1.05E − 84", "1.35E − 81", "1.23E − 80", "5.40E − 81", "131", "IL10, IL10RA, IL12A, IL12B, IL13, IRGM, MASP1, TRAF3, IL17A, ILF3, CEBPB, CD244, HLA-B, AICDA, HLA-C, IDO1, TAGAP, HLA-DPA1, HLA-DPB1, HLA-DQA1, MAPKAPK2, HLA-DQB1, HLA-DRA, HLA-DRB1, MBL2, TNFRSF14, GATA3, PSMB10, CD55, PTPN22, CD46, BCL2, DEFB103B, PTAFR, PTGER4, IL1RL2, CCL26, CD209, STAT5A, BID, DEFB1, DEFB4A, CFD, PTPN6, SLAMF6, FCGR2B, CARD9, BTK, KLRF2, MIF, IL21, PLA2G2A, TOLLIP, C1R, C1S, C4A, C4BPA, CCL7, CCL11, CCL13, BATF3, CCL15, CCL16, C6, C7, CCL18, C8A, CCL19, C8B, CCL20, CCL22, C9, CCL24, CXCL11, XCL1, CX3CL1, NOS2, CXCL12, VCAM1, SELE, RAG2, LILRA2, CLEC6A, BCL2L11, ATG7, ITLN1, ICAM2, ICAM3, IRF8, CXCL13, CASP3, RELA, RELB, TLR9, PPBP, CFI, CR2, IL23A, IFNA2, EDNRB, LGALS3, IFNAR1, IFNB1, IFNG, CSF1R, CSF2, CD8A, CSF2RB, MS4A1, EGR1, SIGIRR, CD80, CD86, TIRAP, CD40, IRAK4, CD44, CD74, CD79B, LTA, HAMP, MAPK11, IL1RAP, IL2, IL4, IL4R, CTSS, IL6, IL6R, IL27, MASP2"], ["GO:0009607", "BP", "RESPONSE to biotic stimulus", "7.42E − 81", "7.65E − 78", "6.99E − 77", "3.83E − 77", "120", "IL10, IL10RA, IL12A, IL12B, IL13, IL13RA1, IRGM, IL16, TRAF3, TNFRSF9, IL17A, CEBPB, HLA-B, PDGFB, HLA-C, TNFSF12, SPP1, HLA-DPA1, HLA-DPB1, HLA-DQA1, MAPKAPK2, HLA-DQB1, HLA-DRA, HLA-DRB1, TNFRSF14, GATA3, ETS1, PSMB10, BCL2, PTAFR, IL1RL2, CCL26, IL17F,STAT5A, STAT6, TNFRSF4, PTPN6, IL22RA2, NFIL3, BTK, MIF, IL21, TOLLIP, CCL7, CCR6, CCL11, CCL13, CCR8, CCL15, MME, CCL16, CCL18, CCL19, CCL20, CCL22,CCL24, CXCL11, XCL1, KIT, CX3CL1, NOS2, CXCL12, VCAM1, IL19, SELE, SELPLG, CCR10, XCR1, TCF7, ZEB1, FN1, IRF8, CXCL13, CASP3, RELA, RELB, PPBP, IL23A, S1PR1, IFNA2, TFRC, IFNAR1, IFNB1, IFNG, LIF, CSF1R, CSF2, CSF2RB, CSF3R, EBI3, EGR1, SIGIRR, IL20, CD80, CD86, TIRAP, IL22, CD40, IRAK4, CD44, TNFRSF13C, CD74, LTA, RORC, HAMP, MAPK11, IL1RAP, IL2, IL3, IL4, IL4R, IL5, IL6, IL6R, IL7, IL26, IL27, CXCR1, IL9, CXCR2"], ["GO:0009607", "BP", "Response to biotic stimulus", "7.42E − 81", "7.65E − 78", "6.99E − 77", "3.83E − 77", "131", "IL10, IL10RA, IL12A, IL12B, IL13, IRGM, MASP1, TRAF3, IL17A, ILF3, CEBPB, CD244, HLA-B, AICDA, HLA-C, IDO1, TAGAP, HLA-DPA1, HLA-DPB1, HLA-DQA1, MAPKAPK2, HLA-DQB1, HLA-DRA, HLA-DRB1, MBL2, TNFRSF14, GATA3, PSMB10, CD55, PTPN22, CD46, BCL2, DEFB103B, PTAFR, PTGER4, IL1RL2, CCL26, CD209, STAT5A, BID, DEFB1, DEFB4A, CFD, PTPN6, SLAMF6, FCGR2B, CARD9, BTK, KLRF2, MIF, IL21, PLA2G2A, TOLLIP, C1R, C1S, C4A, C4BPA, CCL7, CCL11, CCL13, BATF3, CCL15, CCL16, C6, C7, CCL18, C8A, CCL19, C8B, CCL20, CCL22, C9, CCL24, CXCL11, XCL1, CX3CL1, NOS2, CXCL12, VCAM1, SELE, RAG2, LILRA2, CLEC6A, BCL2L11, ATG7, ITLN1, ICAM2, ICAM3, IRF8, CXCL13, CASP3, RELA, RELB, TLR9, PPBP, CFI, CR2, IL23A, IFNA2, EDNRB, LGALS3, IFNAR1, IFNB1, IFNG, CSF1R, CSF2, CD8A, CSF2RB, MS4A1, EGR1, SIGIRR, CD80, CD86, TIRAP, CD40, IRAK4, CD44, CD74, CD79B, LTA, HAMP, MAPK11, IL1RAP, IL2, IL4, IL4R, CTSS, IL6, IL6R, IL27, MASP2"], ["GO:0034097", "BP", "Response to cytokine", "3.04E − 80", "2.61E − 77", "2.39E − 76", "1.57E − 76", "120", "IL10, IL10RA, IL12A, IL12B, IL13, IL13RA1, IRGM, IL16, TRAF3, TNFRSF9, IL17A, CEBPB, HLA-B, PDGFB, HLA-C, TNFSF12, SPP1, HLA-DPA1, HLA-DPB1, HLA-DQA1, MAPKAPK2, HLA-DQB1, HLA-DRA, HLA-DRB1, TNFRSF14, GATA3, ETS1, PSMB10, BCL2, PTAFR, IL1RL2, CCL26, IL17F, STAT5A, STAT6, TNFRSF4, PTPN6, IL22RA2, NFIL3, BTK, MIF, IL21, TOLLIP, CCL7, CCR6, CCL11, CCL13, CCR8, CCL15, MME, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, KIT, CX3CL1, NOS2, CXCL12, VCAM1, IL19, SELE, SELPLG, CCR10, XCR1, TCF7, ZEB1, FN1, IRF8, CXCL13, CASP3, RELA, RELB, PPBP, IL23A, S1PR1, IFNA2, TFRC, IFNAR1, IFNB1, IFNG, LIF, CSF1R, CSF2, CSF2RB, CSF3R, EBI3, EGR1, SIGIRR, IL20, CD80, CD86, TIRAP, IL22, CD40, IRAK4, CD44, TNFRSF13C, CD74, LTA, RORC, HAMP, MAPK11, IL1RAP, IL2, IL3, IL4, IL4R, IL5, IL6, IL6R, IL7, IL26, IL27, CXCR1, IL9, CXCR2"], ["GO:0042110", "BP", "T cell activation", "8.30E − 63", "2.25E − 60", "2.06E − 59", "4.28E − 59", "77", "IL10, IL12A, IL12B, CEBPB, CD244, IDO1, HLA-DMA, HLA-DMB, HLA-DPA1, HLA-DPB1, HLA-DQA1, TNFRSF14, GATA3, PSMB10, CD55, PTPN22, CD46, BCL2, CD83, PTGER4, IL1RL2, CD209, STAT5A, STAT6, TNFRSF4, EOMES, PTPN6, SLAMF6, FCGR2B, IL21, CCR6, CCL19, CCL20, XCL1, KIT, CXCL12, VCAM1, RAG1, RAG2, DPP4, ICOSLG, TCF7, ZEB1, CASP3, AIRE, BTLA, RELB, GPR183, LCK, IL23A, IFNA2, LGALS3, TFRC, IFNAR1, IFNB1, IFNG, CD3E, CD8A, THY1, TIGIT, EBI3, EGR1, CD80, CD86, CD44, CD48, TNFRSF13C, CD74, RORC, CTLA4, IL2, IL4, IL4R, IL6, IL6R, IL7, IL27"], ["GO:0001816", "BP", "Cytokine production", "8.07E − 58", "1.81E − 55", "1.65E − 54", "4.16E − 54", "87", "IL10, IL12A, IL12B, IL13, TRAF3, TNFRSF9, IL17A, CEBPB, CD244, IDO1, HLA-DPA1, HLA-DPB1, MAPKAPK2, IL17B, MBP, TNFRSF14, GATA3, CD55, PTPN22, CD46, PTAFR, CD83, PTGER4, IL1RL2, IL17F, STAT5A, STAT6, TNFRSF4, EOMES, PTPN6, SLAMF6, FCER1A, FCGR2B, CARD9, BTK, KLRF2, MIF, IL21, CCL19, CCL20, XCL1, KIT, CX3CL1, NOS2, IL19, ICOSLG, LILRA2, CLEC6A, FN1, IRF8, AIRE, RELA, RELB, TLR9, IL23A, IFNA2, IFNAR1, IFNB1, IFNG, CD3E, CSF1R, CSF2, TIGIT, EBI3, EGR1,SIGIRR, CD80, CD86, TIRAP, CD34, CD40, IRAK4, TNFRSF13C, CD74,LTA, RORC, MAPK11, IL1RAP, IL2, IL4, IL4R, IL6, IL6R, IL7, IL26, IL27, IL9"], ["GO:0002694", "BP", "Regulation of leukocyte activation", "7.07E − 57", "1.52E − 54", "1.39E − 53", "3.65E − 53", "77", "IL10, IL12A, IL12B, IL13, CEBPB, CD244, IDO1, HLA-DMA, HLA-DMB, HLA-DPA1, HLA-DPB1, HLA-DQA1, CTSC, TNFRSF14, GATA3, CD55, PTPN22, CD46, BCL2, PTAFR, CD83, IL1RL2, CD209, STAT5A, STAT6, TNFRSF4, PTPN6, FCER1A, FCGR2B, BTK, MIF, IL21, CCR6, CCL19, CCL20, XCL1, CX3CL1, VCAM1, RAG1, DPP4, ICOSLG, ZEB1, CASP3, BTLA, GPR183, TLR9, LCK, IL23A, IFNA2, LGALS3, TFRC, IFNB1, IFNG, CD3E, THY1, CD19, TIGIT, EBI3, CD22, CD80, CD86, TIRAP, CD40, CD44, TNFRSF13C, CD74, RORC, CTLA4, HAMP, IL2, IL4, IL4R, IL5, IL6, IL6R, IL7, IL27"], ["GO:0006954", "BP", "Inflammatory response", "5.64E − 55", "1.12E − 52", "1.02E − 51", "2.91E − 51", "82", "IL10, IL12B, IL13, IRGM, IL17A, CEBPB, IDO1, SPP1, MAPKAPK2, CTSC, IL17B, MBL2, GATA3, ETS1, PTAFR, PLA2G2E, PTGER4, IL1RL2, CCL26, IL17F, STAT5A, TNFRSF4, IL22RA2, FCER1A, FCGR2B, BTK,MIF, IL21, PLA2G2A, TOLLIP, C4A, CCL7, CCR6,CCL11, CCL13, CCL15, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, KIT, CX3CL1, NOS2, VCAM1, SELE, XCR1, FN1, NT5E, CXCL13, RELA, RELB, TLR9, PPBP, IL23A, IFNA2, EDNRB, IFNG, CSF1R, SIGIRR, IL20, TIRAP, IL22, CD40, CD44, LTA, HAMP, IL1RAP, IL2, CDH5, IL4, IL4R, IL5, CTSS, IL6, IL6R, IL27, IL9, CXCR2"], ["GO:0007155", "BP", "Cell adhesion", "3.87E − 42", "3.50E − 40", "3.20E − 39", "2.00E − 38", "91", "IL10, IL12A, IL12B, CEBPB,CD244, IDO1, HLA-DMA, HLA-DMB, SPP1, HLA-DPA1, HLA-DPB1, HLA-DQA1, PECAM1, MBP, TNFRSF14, GATA3, ETS1, CD55, PTPN22, CD46, BCL2, PTAFR, CD83, ITGAE, PTGER4, IL1RL2, CD209, PTK2, STAT5A, PTPN6, FCGR2B, IL21, PLAU, CCL11, CCR8, CCL19, XCL1, KIT, MAP4K4, CX3CL1, CXCL12, VCAM1, SELE, SELPLG, RAG1, DPP4, ICOSLG, VTN, FN1, BCL2L11, NT5E, ICAM2, ICAM3, ICAM4, CXCL13, CASP3, RELA, BTLA, LCK, IL23A, S1PR1, IFNA2, LGALS3, TFRC, IFNB1, IFNG, TGFBI, ARHGDIB, CD3E, THY1, CD9, CSF3R, TIGIT, EBI3, CD22, CD80, CD86, ICAM5, CD34, CD44, TNFRSF13C, CD74, CTLA4,IL1RAP, IL2, CDH5, IL4, IL4R, IL6, IL6R, IL7"], ["GO:0009986", "CC", "Cell surface", "8.40E − 48", "1.04E − 45", "6.72E − 45", "3.09E − 45", "83", "IL12A, IL12B, IL13, IL13RA1, TNFRSF9, IL17A, CD244, HLA-B, PDGFB, HLA-C, HLA-DMA, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DRA, HLA-DRB1, PECAM1, MBL2, MBP, TNFRSF14, CD55, CD46, TNFRSF10C, CD83, ITGAE, CD209, TNFRSF4, FCER1A, FCGR2B, FCGRT, MIF, PLAU, CCR6, CCR8, MME, KIT, CX3CL1, CXCL12, VCAM1, CCR10, DPP4, ICOSLG, XCR1, NT5E, BTLA, CR2, S1PR1, LGALS3, TFRC, IFNG, TGFBR1, CD1A, CD3E, CSF1R, CD8A, THY1, CD9, CSF3R, CD19, TIGIT, MS4A1, EBI3, CD22, CD80, CD86, CD34, CD40, CD44, CD48, TNFRSF13C, CD59, CD74, CD79A, CD79B, RORC, CTLA4, CDH5, IL4, CTSS, IL6, IL6R, CXCR1, CXCR2"], ["GO:0097478", "CC", "Leaflet of membrane bilayer", "8.80E − 48", "1.04E − 45", "6.72E − 45", "3.24E − 45", "70", "IL12B, IL13, IL13RA1, TRAF3, TNFRSF9, IL17A, CD244, HLA-B, HLA-C, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, PECAM1, TNFRSF14, PTPN22, CD83, ITGAE, CD209, TNFRSF4, FCER1A, FCGR2B, FCGRT, CCR6, CCR8, KIT, CXCL12, VCAM1, CCR10, ICOSLG, XCR1, BTLA, LCK, CR2, S1PR1, LGALS3, TFRC, IFNG, CD1A, CD3E, BCAP31, CD8A, THY1, CD9, CSF3R, CD19, MS4A1, EBI3, CD22, CD80, CD86, CD34,CD40, CD44, CD48, TNFRSF13C, CD59,CD74, CD79A, CD79B, RORC, CTLA4, CDH5, IL4, IL6, IL6R, CXCR1, CXCR2"], ["GO:0031226", "CC", "Intrinsic component of plasma membrane", "4.10E − 24", "3.01E − 22", "1.96E − 21", "1.51E − 21", "75", "IL13RA1, TRAF3, TNFRSF9,TNFSF12, HLA-DPA1, HLA-DQA1, HLA-DRA, CD46,PTAFR, CD83, ITGAE, IL1RL2, TNFRSF4, CD82, SLAMF6,FCAR, FCER1A, PIGR, FCGR2B, KLRF2, TOLLIP, CCR6, CCR8, MME, C6, C7, C8A, C8B, C9, KIT, VCAM1, SELE, SELPLG, CCR10, ICOSLG, XCR1, LILRA2, ICAM2, ICAM3, ICAM4, BTLA, GPR183, S1PR1, SLC2A1, EDNRB, TFRC, IFNAR1, TGFBR1,CD1A, CD3E, BCAP31, CSF1R, CD8A, THY1, CSF2RB, CD9, CSF3R, CD19, MS4A1, EBI3, CD22, ICAM5, CD34, CD40, CD44, CD48, CD59, CD74, CD79B, CTLA4, IL1RAP, IL4R, IL6, IL6R, CXCR2"], ["GO:0098589", "CC", "Membrane region", "7.35E − 11", "1.93E − 09", "1.25E − 08", "2.70E − 08", "24", "PECAM1, CD55, CD46, STAT6, FCER1A, BTK, MME, SELE, SELPLG, DPP4, ITLN1, CASP3, LCK, S1PR1, SLC2A1, EDNRB, TGFBR1, CD1A, CD8A, THY1, CD19, MS4A1, CD48, CD79A"], ["GO:0043235", "CC", "Receptor complex", "3.10E − 10", "6.71E − 09", "4.35E − 08", "1.14E − 07", "26", "IL12B, IL13RA1, TRAF3, ITGAE, PTPN6, PIGR, TOLLIP, KIT, ITLN1, CR2, TFRC, TGFBR1, CD3E, CSF1R, CD8A, CSF2RB, CSF3R, EBI3, CD40, CD44, CD74, CD79A, CD79B, IL4R, IL6, IL6R"], ["GO:0030141", "CC", "Secretory granule", "3.67E − 07", "5.20E − 06", "3.37E − 05", "1.35E − 04", "29", "PDGFB, CTSC, PECAM1, CD55, CD46, PTAFR, CFD, PTPN6, FCAR, PIGR, FCGR2A, MIF, PLA2G2A, TOLLIP, PLAU, MME, KIT, GPI, LILRA3, FN1, ATG7, PPBP, LGALS3, CD9, CD44, CD59, CTSS, CXCR1, CXCR2"], ["GO:0005764", "CC", "Lysosome", "1.31E − 06", "1.49E − 05", "9.69E − 05", "4.81E − 04", "25", "IL13, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, CTSC, HLA-DRB1, FCER1A, PIGR, BTK, TOLLIP,KIT, DPP4, TLR9, IFNAR1, CD34, CD74, IL4, IL4R, CTSS, CXCR2"], ["GO:0005794", "CC", "Golgi apparatus", "4.18E − 03", "2.00E − 02", "1.30E − 01", "1.00E + 00", "31", "IRGM, HLA-B, PDGFB, HLA-C,SPP1, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, CTSC, HLA-DRB1, CD55, CD46, DEFB103B, DEFB1,DEFB4A, MME, VCAM1, DPP4, VTN, TLR9, SLC2A1, TGFBI, BCAP31, CD44, CD59, CD74, CD79B, B3GAT1, CTLA4"], ["GO:0048471", "CC", "Perinuclear region of cytoplasm", "2.87E − 02", "8.46E − 02", "5.49E − 01", "1.00E + 00", "16", "TNFSF12, SPP1, PTPN22, BCL2, BTK, PLA2G2A, TOLLIP, CX3CL1, NOS2, SELE, ATG7,TFRC, TRAF4, BCAP31, CD34, CTLA4"], ["GO:0044297", "CC", "Cell body", "9.03E − 02", "2.08E − 01", "1.00E + 00", "1.00E + 00", "14", "PDGFB, MBP, PTGER4, FCGR2B, C4A, MME, CX3CL1, CASP3,IFNG, CD3E, THY1, CD22, CD40, IL6R"], ["GO:0030054", "CC", "Cell junction", "9.70E − 02", "2.20E − 01", "1.00E + 00", "1.00E + 00", "21", "PECAM1, CD46, PTK2, PTPN6, C4A, PLAU, MME, KIT, MAP4K4, DPP4, LCK, SLC2A1, TGFBR1, TRAF4, CD3E, THY1, CD9, CD44,CD59, HAMP, CDH5"], ["GO:0005126", "MF", "Cytokine receptor binding", "8.37E − 54", "6.01E − 51", "4.30E − 50", "6.01E − 51", "59", "IL10, IL12A, IL12B, IL13, TRAF3, TNFSF12, GATA3, DEFB103B, CCL26, IL17F, BID, DEFB1, DEFB4A, MIF, IL21, TOLLIP, CCL7, CCL11, CCL13, CCL15, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, CX3CL1, CXCL12, CXCL13, CASP3, TLR9, PPBP, IL23A, IFNA2, IFNB1, IFNG, TGFBR1, LIF, TRAF4, CSF2, EBI3, IL20, IL22,IRAK4, CD44, LTA, IL1RAP, IL2,IL3, CDH5,IL4, IL5, IL6, IL6R, IL7, IL27, IL9"], ["GO:0005102", "MF", "Signaling receptor binding", "3.78E − 49", "9.05E − 47", "6.48E − 46", "2.72E − 46", "108", "IL10, IL12A, IL12B, IL13, IL16, TRAF3, IL17A, CEBPB, CD244, HLA-B, PDGFB, HLA-C, TNFSF12, HLA-DOB, SPP1, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, IL17B, MBL2, GATA3, DEFB103B, CCL26, IL17F, PTK2, BID, DEFB1, DEFB4A, PTPN6, PIGR, MIF, IL21, TOLLIP, CCL7, CCL11, CCL13, CCL15, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, CX3CL1, CXCL12, VCAM1, IL19, SELPLG, GPI, DPP4, ICOSLG, VTN, FN1, ATG7, ICAM2, ICAM3, ICAM4, CXCL13, CASP3, TLR9, LCK, PPBP, IL23A, S1PR1, IFNA2, EDNRB, LGALS3, IFNB1, IFNG, TGFBI, TGFBR1, LIF, TRAF4, CD3E,BCAP31, CSF2, CD8A, THY1, CD9, TIGIT, MS4A1, EBI3, CD22, IL20, CD86, ICAM5, TIRAP, IL22, IRAK4, CD44, CD74, LTA, HAMP, IL1RAP, IL2, IL3, CDH5, IL4, IL5, IL6, IL6R, IL7, IL26, IL27, IL9"], ["GO:0030545", "MF", "Chemokine receptor binding", "2.63E − 22", "2.36E − 20", "1.69E − 19", "1.89E − 19", "20", "DEFB103B, CCL26, DEFB1, DEFB4A, CCL7, CCL11,CCL13, CCL15, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, CX3CL1, CXCL12, CXCL13, PPBP"], ["GO:0098772", "MF", "Molecular function regulator", "1.42E − 18", "6.80E − 17", "4.86E − 16", "1.02E − 15", "71", "IL10, IL12A, IL12B, IL13, IRGM, IL16, IL17A, PDGFB, TNFSF12, SPP1, TAGAP, CTSC, IL17B, CD46, BCL2, DEFB103B, CCL26, IL17F, EOMES, DEFB4A, MIF, IL21, C4A, CCL7, CCL11, CCL13, CCL15, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, CX3CL1, NOS2, CXCL12, IL19, GPI, FN1, CXCL13, CASP3, SKI, PPBP, IL23A, IFNA2, LGALS3, IFNB1, IFNG, LIF, ARHGDIB, TRAF4, CSF2, THY1, EBI3, IL20, TIRAP, IL22, LTA, HAMP, IL2, IL3, IL4, IL5, IL6, IL6R, IL7, IL26,IL27, IL9"], ["GO:0004888", "MF", "Transmembranesignaling receptor activity", "2.09E − 12", "8.81E − 11", "6.31E − 10", "1.50E − 09", "50", "IL10RA, IL12B, IL13RA1, HLA-DOB, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRA, TNFRSF14, TNFRSF10C, PTAFR, PTGER4, IL1RL2, TNFRSF4, PTPN6, IL22RA2, FCER1A, PIGR, FCGR2B, CCR6, CCR8, KIT, KLRB1, LILRB5, SELE, CCR10, XCR1, LILRA1, GPR183, TLR9, CR2, S1PR1, EDNRB, IFNAR1, IFNG, TGFBR1, CD3E, CSF1R, CSF2RB, CSF3R, EBI3, CD44, CD74, CD79A, CD79B, IL1RAP, IL4R, IL6R, CXCR1, CXCR2"], ["GO:0001664", "MF", "G protein-coupled receptor binding", "3.80E − 12", "1.52E − 10", "1.08E − 09", "2.73E − 09", "23", "DEFB103B, CCL26, DEFB1, DEFB4A, CCL7, CCL11, CCL13, CCL15, CCL16, CCL18, CCL19, CCL20, CCL22, CCL24, CXCL11, XCL1, CX3CL1, CXCL12, CXCL13, PPBP, S1PR1, EDNRB, IL2"], ["GO:0044877", "MF", "Protein-containing complex binding", "1.24E − 11", "4.46E − 10", "3.19E − 09", "8.92E − 09", "48", "PDGFB, HLA-DMA, HLA-DMB, HLA-DOB, SPP1, HLA-DRA, HLA-DRB1, PTK2, FCAR, FCER1A, PIGR, FCGR2A, FCGR2B, FCGRT, MIF, C8A, C8B, CX3CL1, CXCL12, VCAM1, DPP4, LILRA2, VTN, FN1, BCL2L11, ICAM2, ICAM3, ICAM4, CASP3, RELA, LCK, IFNA2, LGALS3, IFNB1, TGFBI, TGFBR1, CD3E, BCAP31, CD8A, THY1, CD9, MS4A1, CD22, ICAM5, CD44, CD74, CDH5, CTSS"], ["GO:0042802", "MF", "IDENTICAL protein binding", "1.81E − 07", "3.93E − 06", "2.81E − 05", "1.30E − 04", "51", "IL12B, MASP1, CEBPB, AICDA, PDGFB, CTSC, PECAM1, ETS1, BCL2, IL17F, PTK2, STAT6, DEFB1, CARD9, BTK, KLRF2, MIF, C1S, MME, XCL1, KIT, NOS2, RAG1, DPP4, ICOSLG, TCF4, IKZF2, VTN, FN1, ATG7, ITLN1, AIRE, RELA, RELB, TLR9, LCK, CR2, SLC2A1, LGALS3, TFRC, TRAF4, CD3E, CSF1R, CD8A, TIGIT, TIRAP, CD74, CD79A, CD79B, CDH5, IL6R"], ["GO:0046983", "MF", "Protein dimerization activity", "6.79E − 07", "1.19E − 05", "8.51E − 05", "4.88E − 04", "42", "IL10, IL12A, IL12B, MASP1, CEBPB, PDGFB, HLA-DQA1, PECAM1, GATA3, BCL2, IL17F, BID, CARD9, KLRF2, CCL11, MME, TAL1, XCL1, KIT, NOS2, RAG1, DPP4, TCF4, IKZF2, BCL2L11, ATG7, CXCL13, RELA, TLR9, CR2, LGALS3, TFRC, TGFBR1, TRAF4, CD3E, CSF1R, CD8A, TIRAP, CD79A, CD79B, CDH5, IL6R"], ["GO:0016301", "MF", "Kinase activity", "1.16E − 05", "1.54E − 04", "1.10E − 03", "8.29E − 03", "40", "IL12B, IRGM, PDGFB, MAPKAPK2, PTPN22, PTK2, TNFRSF4, PTPN6, FCER1A, BTK, MIF, CCL19, TAL1, KIT, MAP4K4, NOS2, GPI, DUSP4, CASP3, TLR9, LCK, IL23A, IFNG, TGFBR1, TRAF4, CSF1R, THY1, CD19, EGR1, TIRAP, CD40, IRAK4, CD44, CD74, MAPK11, IL2, IL3, IL4, IL6, IL6R"]], "row_count": 32, "column_count": 9, "numeric_cells": 217, "header_rows": 1, "locator": "section[14]/table-wrap[2]#Tab5"}}, {"id": "asset:table:pmid:33251083:14", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:72eaeba363b965fe7e952d91d5d134b882754beaa91740a8a3be9d2804db13fb", "bytes": 16979, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[15]/table-wrap[1]#Tab6", "version": null, "note": "Topology table for up and down regulated genes", "structure": {"pmcid": "PMC7679428", "section_index": 15, "section_title": "PPI network construction and module analysis", "row_count": 277, "column_count": 7}, "table": {"label": "Table 6", "caption": "Topology table for up and down regulated genes", "rows": [["Regulation", "Node", "Degree", "Betweenness", "Stress", "Closeness", "Clustering Coefficient"], ["Up", "TP53", "682", "0.308256", "69419762", "0.44613", "0.001042"], ["Up", "HRAS", "543", "0.243425", "36147274", "0.454702", "0.003568"], ["Up", "CTNNB1", "454", "0.17049", "60805652", "0.403018", "0.002042"], ["Up", "FYN", "396", "0.117564", "12570856", "0.436236", "0.010907"], ["Up", "ABL1", "362", "0.118179", "7631538", "0.470883", "0.015228"], ["Up", "JAK2", "258", "0.054758", "7164820", "0.434802", "0.021748"], ["Up", "STAT3", "253", "0.05294", "16470742", "0.398767", "0.02108"], ["Up", "JAK1", "223", "0.032981", "6336566", "0.40235", "0.019876"], ["Up", "TRAF6", "216", "0.074546", "12176648", "0.395301", "0.010207"], ["Up", "STAT1", "213", "0.045072", "12845532", "0.387307", "0.023031"], ["Up", "TRAF2", "171", "0.047572", "11238720", "0.357837", "0.007981"], ["Up", "ZAP70", "153", "0.018814", "3346658", "0.375226", "0.028294"], ["Up", "IKBKB", "140", "0.040639", "5153454", "0.403521", "0.017575"], ["Up", "MX1", "125", "0.057134", "6475242", "0.352549", "0.002194"], ["Up", "STAT5B", "118", "0.012758", "2934924", "0.377415", "0.057801"], ["Up", "ZBTB16", "105", "0.029011", "4339392", "0.371064", "0.00696"], ["Up", "GP1BB", "104", "0.024662", "2308816", "0.350596", "0.009335"], ["Up", "RUNX1", "95", "0.021204", "3579930", "0.370309", "0.010526"], ["Up", "C1QBP", "89", "0.043687", "7011558", "0.334675", "0"], ["Up", "TLR2", "85", "0.019615", "2401022", "0.374839", "0.034734"], ["Up", "SOCS1", "85", "0.019595", "1846156", "0.398713", "0.072829"], ["Up", "SMAD5", "82", "0.024208", "4462604", "0.336687", "0.003011"], ["Up", "ITGB2", "72", "0.025976", "3349086", "0.351061", "0.008607"], ["Up", "IKZF1", "72", "0.011714", "1722502", "0.373157", "0.034038"], ["Up", "CCND3", "71", "0.025956", "2361424", "0.357661", "0.008048"], ["Up", "ATG5", "60", "0.020131", "2294688", "0.333219", "0.00678"], ["Up", "IFIH1", "59", "0.023459", "2059722", "0.333945", "0.001753"], ["Up", "STAT4", "58", "0.002561", "797810", "0.366902", "0.082275"], ["Up", "PSMB9", "55", "0.0248", "2740768", "0.310739", "0"], ["Up", "IKZF3", "47", "0.005026", "756292", "0.361346", "0.053654"], ["Up", "GFI1", "46", "0.007563", "811180", "0.357266", "0.013527"], ["Up", "IRF7", "44", "0.010411", "1198488", "0.338804", "0.008457"], ["Up", "MAP4K1", "44", "0.006432", "851692", "0.348957", "0.046512"], ["Up", "CD247", "43", "0.00724", "710792", "0.349292", "0.058693"], ["Up", "LCP2", "41", "0.003353", "442356", "0.338331", "0.07439"], ["Up", "CCR5", "39", "0.010719", "942222", "0.343359", "0.043185"], ["Up", "IRF5", "34", "0.006222", "736764", "0.339277", "0.012478"], ["Up", "GZMB", "29", "0.01009", "1297184", "0.313584", "0"], ["Up", "IL2RG", "27", "0.005284", "347620", "0.3463", "0.071225"], ["Up", "TBX21", "23", "0.003781", "493896", "0.328704", "0.023715"], ["Up", "XBP1", "21", "0.004344", "440004", "0.329933", "0"], ["Up", "HLA-A", "19", "0.007447", "822622", "0.311637", "0"], ["Up", "MAP4K2", "18", "0.002038", "190802", "0.334636", "0.045752"], ["Up", "CCR1", "18", "0.004542", "722956", "0.323912", "0.019608"], ["Up", "IFNAR2", "17", "0.003686", "214358", "0.335872", "0.169118"], ["Up", "ITGAL", "17", "0.004258", "302784", "0.285588", "0.058824"], ["Up", "ATG10", "16", "0.00303", "204222", "0.278618", "0.075"], ["Up", "CEACAM1", "15", "0.003567", "815206", "0.308991", "0"], ["Up", "CLEC7A", "13", "0.006223", "422114", "0.302253", "0"], ["Up", "CUL9", "10", "0.001917", "66468", "0.352806", "0.111111"], ["Up", "SERPING1", "10", "0.004857", "805696", "0.203225", "0"], ["Up", "NLRP3", "10", "0.002325", "208526", "0.304371", "0"], ["Up", "LTB4R", "9", "0.002812", "970594", "0.242059", "0"], ["Up", "GBP1", "9", "0.001571", "66852", "0.307489", "0"], ["Up", "LILRB2", "9", "0.004803", "191694", "0.287677", "0"], ["Up", "CD99", "8", "0.002792", "99752", "0.324129", "0"], ["Up", "KLRK1", "7", "0.003445", "544176", "0.26256", "0"], ["Up", "BST2", "7", "1.93E − 04", "36836", "0.324273", "0"], ["Up", "KLRD1", "7", "0.001389", "97132", "0.22517", "0.047619"], ["Up", "KLRC1", "5", "0.003221", "307724", "0.286234", "0.1"], ["Up", "IL18R1", "4", "0.00118", "348338", "0.245924", "0"], ["Up", "PDCD1", "4", "0.001374", "55018", "0.303894", "0.166667"], ["Up", "SLAMF7", "4", "0.00206", "191070", "0.233272", "0"], ["Up", "C2", "4", "0.001446", "96444", "0.245447", "0"], ["Up", "IFI35", "3", "6.93E − 04", "23710", "0.323301", "0"], ["Up", "LAG3", "2", "4.23E − 06", "1074", "0.245695", "0"], ["Up", "IL18RAP", "2", "1.95E − 04", "52194", "0.233609", "0"], ["Down", "MAPK11", "421", "0.179413", "26118522", "0.388195", "0.003744"], ["Down", "RELA", "285", "0.126824", "20931198", "0.37804", "0.004645"], ["Down", "LCK", "267", "0.108492", "11305268", "0.405534", "0.014108"], ["Down", "KIT", "221", "0.051071", "10158794", "0.36783", "0.015014"], ["Down", "EGR1", "195", "0.060886", "6334914", "0.384414", "0.016178"], ["Down", "ILF3", "179", "0.093546", "7805892", "0.330116", "3.14E − 04"], ["Down", "CASP3", "175", "0.070326", "10842834", "0.355181", "0.005123"], ["Down", "PTK2", "153", "0.049652", "8738870", "0.356704", "0.005246"], ["Down", "PTPN6", "150", "0.044684", "5323296", "0.365645", "0.021477"], ["Down", "BCL2", "150", "0.062256", "5772430", "0.365862", "0.009128"], ["Down", "BTK", "137", "0.022999", "3449618", "0.35359", "0.019429"], ["Down", "STAT5A", "126", "0.024378", "5096524", "0.35745", "0.027429"], ["Down", "TGFBR1", "123", "0.048955", "6050368", "0.349257", "0.007464"], ["Down", "CSF1R", "117", "0.01327", "3411424", "0.344835", "0.005894"], ["Down", "FN1", "116", "0.052141", "5201654", "0.335331", "0.003148"], ["Down", "TCF4", "115", "0.044569", "5794596", "0.333586", "0.005492"], ["Down", "TRAF3", "113", "0.038869", "4088284", "0.341886", "0.010588"], ["Down", "STAT6", "102", "0.026319", "3212830", "0.363486", "0.039216"], ["Down", "GATA3", "97", "0.03064", "3006348", "0.350689", "0.018471"], ["Down", "IRAK4", "90", "0.015953", "2526624", "0.344064", "0.010986"], ["Down", "TCF7", "90", "0.029254", "4190222", "0.323796", "9.99E − 04"], ["Down", "ATG7", "88", "0.032475", "4557368", "0.323761", "0"], ["Down", "PSMB10", "86", "0.037084", "3948650", "0.316536", "0"], ["Down", "EGR2", "78", "0.014472", "2942228", "0.323966", "0.002331"], ["Down", "CEBPB", "77", "0.01563", "2080316", "0.347208", "0.028708"], ["Down", "TLR9", "75", "0.01613", "2504516", "0.335623", "0.017658"], ["Down", "ETS1", "74", "0.015119", "2229504", "0.345493", "0.023695"], ["Down", "MBP", "69", "0.02034", "1946892", "0.33211", "0.008099"], ["Down", "CD40", "63", 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["Down", "TGFBI", "10", "7.77E − 04", "51700", "0.253167", "0.155556"], ["Down", "CD209", "10", "4.47E − 04", "37928", "0.243628", "0.044444"], ["Down", "NT5E", "10", "0.003249", "169846", "0.314627", "0.022222"], ["Down", "IL10RA", "10", "0.001722", "123836", "0.32116", "0.155556"], ["Down", "MBL2", "9", "0.002733", "247190", "0.248106", "0.027778"], ["Down", "TNFRSF9", "9", "0.001065", "77604", "0.309005", "0.305556"], ["Down", "HLA-DQA1", "9", "8.50E − 04", "84902", "0.306147", "0.194444"], ["Down", "NFIL3", "9", "0.002148", "269802", "0.253063", "0"], ["Down", "MS4A1", "9", "6.53E − 04", "54246", "0.308664", "0.083333"], ["Down", "PTAFR", "9", "0.001839", "146258", "0.315401", "0.055556"], ["Down", "MASP1", "9", "0.002137", "326806", "0.225528", "0.083333"], ["Down", "PLA2G2A", "8", "0.002039", "625578", "0.228338", "0"], ["Down", "TNFRSF4", "8", "7.20E − 04", "87330", "0.26198", "0.321429"], ["Down", "IL13RA1", "8", "6.92E − 04", "54632", "0.3129", "0.214286"], ["Down", "CD48", 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"CD34", "5", "0.001329", "226272", "0.243224", "0"], ["Down", "IFNG", "5", "0.001405", "110736", "0.270285", "0"], ["Down", "IL23A", "5", "0.00132", "310874", "0.180846", "0.1"], ["Down", "EBI3", "5", "0.001288", "90012", "0.222769", "0.1"], ["Down", "C8B", "4", "2.59E − 04", "21386", "0.208212", "0.166667"], ["Down", "CCL20", "4", "0.001697", "215266", "0.242974", "0"], ["Down", "C4BPA", "4", "0.001305", "202342", "0.207217", "0"], ["Down", "C8A", "4", "5.17E − 04", "27442", "0.225528", "0.333333"], ["Down", "SLAMF6", "4", "6.38E − 06", "766", "0.274209", "0.333333"], ["Down", "CCR6", "4", "0.001956", "273648", "0.209231", "0"], ["Down", "BTLA", "4", "6.84E − 04", "61880", "0.275584", "0.333333"], ["Down", "CCR8", "4", "6.64E − 04", "48144", "0.196954", "0"], ["Down", "CXCL11", "4", "8.55E − 05", "11782", "0.220629", "0"], ["Down", "SIGIRR", "4", "3.08E − 06", "666", "0.277147", "0.333333"], ["Down", "ITLN1", "4", "0.001313", "85710", "0.272679", "0"], ["Down", "ICAM5", "4", "3.97E − 05", "5052", "0.242936", "0"], ["Down", "FCGRT", "4", "0.001307", "236680", "0.210779", "0"], ["Down", "CCL22", "4", "5.04E − 04", "43848", "0.247169", "0"], ["Down", "IL12B", "4", "1.64E − 04", "39054", "0.194859", "0.5"], ["Down", "IL27", "3", "2.87E − 04", "26194", "0.215697", "0.333333"], ["Down", "IL22", "3", "6.54E − 04", "37474", "0.199417", "0"], ["Down", "C7", "3", "1.54E − 04", "29126", "0.226657", "0"], ["Down", "TIGIT", "3", "0.001299", "79710", "0.18742", "0"], ["Down", "DEFB4A", "3", "0.002265", "309432", "0.250917", "0"], ["Down", "IL22RA2", "3", "8.49E − 04", "82918", "0.216806", "0"], ["Down", "IL21", "3", "2.06E − 05", "882", "0.21301", "0"], ["Down", "C9", "3", "1.97E − 05", "976", "0.229359", "0.333333"], ["Down", "LIF", "3", "1.35E − 05", "994", "0.252689", "0"], ["Down", "ITGAE", "3", "6.54E − 04", "122018", "0.226607", "0"], ["Down", "IL5", "3", "2.60E − 05", "1936", "0.26283", "0.333333"], ["Down", "HLA-DPB1", "2", "0", "0", "0.240356", "1"], ["Down", "CFI", "2", "6.50E − 04", "65960", "0.196527", "0"], ["Down", "IFNB1", "2", "0", "0", "0.254275", "1"], ["Down", "IFNA2", "2", "0", "0", "0.254275", "1"], ["Down", "XCL1", "2", "0.001299", "97076", "0.208706", "0"], ["Down", "CD1A", "2", "6.50E − 04", "79654", "0.20475", "0"], ["Down", "XCR1", "2", "6.50E − 04", "48540", "0.172698", "0"], ["Down", "DEFB103B", "2", "6.50E − 04", "91060", "0.173057", "0"], ["Down", "IL7", "2", "6.20E − 07", "68", "0.219497", "0"], ["Down", "KLRB1", "2", "6.50E − 04", "58078", "0.267815", "0"], ["Down", "IL20", "2", "0.666667", "4", "0.75", "0"], ["Down", "HLA-DMB", "1", "0", "0", "0.201796", "0"], ["Down", "HLA-DOB", "1", "0", "0", "0.16794", "0"], ["Down", "ICOSLG", "1", "0", "0", "0.200469", "0"], ["Down", "CD83", "1", "0", "0", "0.300029", "0"], ["Down", "GPR183", "1", "0", "0", "0.300029", "0"], ["Down", "IKBKAP", "1", "0", "0", "0.250938", "0"], ["Down", "DEFB1", "1", "0", "0", "0.173038", "0"], ["Down", "IL1RL2", "1", "0", "0", "0.20772", "0"], ["Down", "IL19", "1", "0", "0", "0.5", "0"]], "row_count": 277, "column_count": 7, "numeric_cells": 1443, "header_rows": 1, "locator": "section[15]/table-wrap[1]#Tab6"}}, {"id": "asset:table:pmid:33251083:15", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:9f3e4a1eac95f4caba623fab38d02663f148640b1982a308e2735b6d1ad0a952", "bytes": 10788, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[16]/table-wrap[1]#Tab7", "version": null, "note": "miRNA - target gene interaction table", "structure": {"pmcid": "PMC7679428", "section_index": 16, "section_title": "Construction of target gene–miRNA regulatory network", "row_count": 185, "column_count": 8}, "table": {"label": "Table 7", "caption": "miRNA - target gene interaction table", "rows": [["Regulation", "Target Genes", "Degree", "MicroRNA", "Regulation", "Target Genes", "Degree", "MicroRNA"], ["Up", "IKZF3", "134", "hsa-mir-6860", "Down", "SKI", "210", "hsa-mir-5100"], ["Up", "TP53", "130", "hsa-mir-5703", "Down", "TNFRSF13C", "136", "hsa-mir-3197"], ["Up", "IFNAR2", "109", "hsa-mir − 4510", "Down", "BCL2L11", "122", "hsa-mir-8064"], ["Up", "SMAD5", "83", "hsa-mir-6086", "Down", "ICOSLG", "119", "hsa-mir-3672"], ["Up", "STAT3", "80", "hsa-mir − 4270", "Down", "IL6R", "94", "hsa-mir-7641"], ["Up", "TRAF6", "71", "hsa-mir-6745", "Down", "VCAM1", "86", "hsa-mir − 4270"], ["Up", "RUNX1", "67", "hsa-mir − 4467", "Down", "LILRA2", "83", "hsa-mir − 4780"], ["Up", "ABL1", "64", "hsa-mir − 4511", "Down", "IRAK4", "78", "hsa-mir-520e"], ["Up", "KLRD1", "60", "hsa-mir-5094", "Down", "BTLA", "72", "hsa-mir-3133"], ["Up", "CCL5", "49", "hsa-mir − 4775", "Down", "CD55", "71", "hsa-mir-6124"], ["Up", "CTNNB1", "48", "hsa-mir − 4255", "Down", "CCL22", "71", "hsa-mir-5190"], ["Up", "MAP4K2", "47", "hsa-mir-6131", "Down", "CD44", "70", "hsa-mir-5696"], ["Up", "PSMB9", "44", "hsa-mir-3658", "Down", "PDGFB", "69", 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