SLC39A1 contribute to malignant progression and have clinical prognostic impact in gliomas.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:33292262", "kind": "science-record", "revision": 7, "content_hash": "sha256:80534db3a4a45909b62f962b644f0111e22c752b05274d94b48b1a05e5d5bd99", "created_at": "2026-11-01T15:41:18Z", "updated_at": "2026-11-01T22:02:41Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "SLC39A1 contribute to malignant progression and have clinical prognostic impact in gliomas.", "doi": "10.1186/s12935-020-01675-0", "pmid": "33292262", "authors": ["Peng Wang", "Jingjing Zhang", "Shuai He", "Boan Xiao", "Xiaobin Peng"], "journal": "Cancer cell international", "year": 2020, "abstract": "BACKGROUND: Gliomas are one of the most common primary tumors of the central nervous system, and have an unfavorable prognosis. SLC39A1 is a zinc ion transport protein which inhibits the progression of prostate cancer. By studying the role and mechanism of SLC39A1 in the progression of gliomas, perhaps a new therapeutic target can be provided for their treatment.\nMETHOD: The TCGA, CCGA, GSE16011, GSE44971 and GSE11260 data sets were employed to evaluate the expression level of SLC39A1 in paracancerous and glioma tissues. In addition, Kaplan-Meier analysis, Cox analysis, and the ESTIMATE and CIBERSORT algorithms were used to analyze its prognostic value and immune infiltration correlation. A CCK-8 and flow cytometer were used to measure the effects of SLC39A1 on U87 cell proliferation or apoptosis; RT-qPCR and western blot were used to detect its effects on the expression of MMP2\\MMP9.\nRESULTS: SLC39A1 has up-regulated expression in glioma tissues. High SLC39A1 expression predicted significantly worse survival. Univariate and multivariate analysis show that SLC39A1 independently indicated poor prognosis in patients with gliomas. The expression of SLC39A1 is significantly correlated with clinical pathological parameters such as Grade, IDH mutation status, and 1p19q codeletion status. In vitro experimental results show that SLC39A1 promotes proliferation of glioma cells, inhibits their apoptosis, and promotes expression of MMP2\\MMP9. In addition, it may affect infiltration of immune cells into the glioma microenvironment.\nCONCLUSION: SLC39A1 may serve as a new prognostic biomarker and potential target for treatment of gliomas.", "claims": [{"id": "claim-method", "statement": "Kaplan–Meier survival analysis was used to assess The prognostic value of SLC39A1.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:33292262", "locator": "sections[12] \"Statistical analysis\" paragraph 2", "quote": "Kaplan–Meier survival analysis was used to assess The prognostic value of SLC39A1."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:33292262", "locator": "sections[30] \"notes\" paragraph 1", "quote": "The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "partial", "objective": null, "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:33292262"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "blocked", "blocked_on": "data:accession_absent", "description": "The GEO series accession resolves and its sample accessions are listed. 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the checksum covers the rendered section body, not the original XML bytes.", "structure": {"pmcid": "PMC7694905", "source": "europe_pmc_fulltext", "coverage": "whole_body_without_references", "text_hash_scope": "rendered_section_body"}}, {"id": "asset:table:pmid:33292262:1", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:7929a9eda725051e7a2f737e4f3f34966459a1f5652c109c2581f9c975cf1f8e", "bytes": 1150, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[22]/table-wrap[1]#Tab1", "version": null, "note": "Correlation between SLC39A1 and 22 subtypes of immune cell in glioma samples", "structure": {"pmcid": "PMC7694905", "section_index": 22, "section_title": "SLC39A1 is associated with immune infiltration of gliomas", "row_count": 23, "column_count": 3}, "table": {"label": "Table 1", "caption": "Correlation between SLC39A1 and 22 subtypes of immune cell in glioma samples", "rows": [["Inmune cells", "Cor", "P"], ["Macrophages M2", "0.336", "< 0.001"], ["Macrophages M0", "0.309", "< 0.001"], ["Eosinophils", "0.261", "< 0.001"], ["T cells regulatory (Tregs)", "0.195", "< 0.001"], ["T cells gamma delta", "0.18", "< 0.001"], ["Macrophages M1", "0.093", "0.013"], ["T cells CD4 memory activated", "0.081", "0.032"], ["Dendritic cells activated", "0.067", "0.076"], ["NK cells resting", "0.053", "0.16"], ["T cells CD4 memory resting", "0.051", "0.18"], ["Neutrophils", "0.022", "0.564"], ["T cells CD8", "−0.033", "0.384"], ["Plasma cells", "−0.039", "0.305"], ["Dendritic cells resting", "−0.049", "0.192"], ["B cells naive", "−0.094", "0.012"], ["B cells memory", "−0.101", "0.007"], ["Mast cells resting", "−0.18", "< 0.001"], ["T cells follicular helper", "−0.181", "< 0.001"], ["Monocytes", "−0.193", "< 0.001"], ["Mast cells activated", "−0.211", "< 0.001"], ["T cells CD4 naive", "−0.24", "< 0.001"], ["NK cells activated", "−0.268", "< 0.001"]], "row_count": 23, "column_count": 3, "numeric_cells": 44, "header_rows": 1, "locator": "section[22]/table-wrap[1]#Tab1"}}], "gaps": []}, "analysis": {"state": "partial", "methods": [{"id": "method-1", "family": "group_comparison", "specific": "anova", "label": "Group comparison", "dsl_operations": ["group_summary", "welch_t", "bootstrap_mean_difference", "group_comparison_anova"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["two_or_more_groups_continuous"], "evidence": {"score": 0.8, "band": "high", "quote": "ANOVA"}}, {"id": "method-2", "family": "survival_analysis", "specific": "kaplan_meier", "label": "Survival analysis", "dsl_operations": ["survival_km"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["time_to_event_with_censoring"], "evidence": {"score": 0.7, "band": "medium", "quote": "Kaplan-Meier"}}, {"id": "method-3", "family": "survival_analysis", "specific": "cox_proportional_hazards", "label": "Survival analysis", "dsl_operations": ["cox_ph"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["time_to_event_with_censoring"], "evidence": {"score": 0.8, "band": "high", "quote": "Cox regression"}}, {"id": "method-4", "family": null, "specific": null, "label": "Kaplan–Meier survival analysis", "dsl_operations": [], "missing_operations": [], "expressible": null, "parameters": {}, "data_shapes": [], "evidence": {"score": 1.0, "band": "verbatim", "quote": "Kaplan–Meier survival analysis was used to assess The prognostic value of SLC39A1."}}], "targets": [], "gaps": ["method.reader_named_unmapped"]}, "capability": {"state": "complete", "requirements": [{"capability_id": "capability:computational_analysis", "label": "Computational analysis platform", "assay_families": ["meta_analysis", "machine_learning", "survival_analysis", "statistical_regression", "pca", "molecular_docking", "network_analysis", "differential_expression", "gwas"], "availability_state": "owned", "tier_unlocked": "R1", "candidate": "Automated Assays Laravel application and simulated adapters"}], "gaps": []}, "readiness": {"state": "blocked", "tier": "R4", "blocking_axis": "data", "blocked_on": "data:accession_absent", "axes": {"method": {"tier": "R1", "expressible": true, "required_operations": ["group_summary", "welch_t", "bootstrap_mean_difference", "group_comparison_anova"], "missing_operations": [], "basis": "The paper names the method it used and the corpus's method extractor maps it onto the DSL catalogue: anova."}, "capability": {"tier": "R1", "capability_id": "capability:computational_analysis", "availability_state": "owned", "basis": "The computational analysis is owned. 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