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pmid:33436002
Genomic instability-derived plasma extracellular vesicle-microRNA signature as a minimally invasive predictor of risk and unfavorable prognosis in breast cancer.
Siqi Bao · Ting Hu · Jiaqi Liu · Jianzhong Su · Jie Sun · Yue Ming · Jiaxin Li · Nan Wu · Hongyan Chen · Meng Zhou
Journal of nanobiotechnology · 2021 doi:10.1186/s12951-020-00767-3
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Complete file
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Recent studies have indicated that microRNA (miRNA) regulation in genomic instability (GI) is associated with disease risk and clinical outcome. Herein, we aimed to identify the GI-derived miRNA signature in extracellular vesicles (EVs) as a minimally invasive biomarker for early diagnosis and prognostic risk stratification.\nEXPERIMENTAL DESIGN: Integrative analysis of miRNA expression and somatic mutation profiles was performed to identify GI-associated miRNAs. Then, we constructed a discovery and validation study with multicenter prospective cohorts. The GI-derived miRNA signature (miGISig) was developed in the TCGA discovery cohort (n = 261), and was subsequently independently validated in internal TCGA validation (n = 261) and GSE22220 (n = 210) cohorts for prognosis prediction, and in GSE73002 (n = 3966), GSE41922 (n = 54), and in-house clinical exosome (n = 30) cohorts for diagnostic performance.\nRESULTS: We identified a GI-derived three miRNA signature (MIR421, MIR128-1 and MIR128-2) in the serum extracellular vesicles of BC patients, which was significantly associated with poor prognosis in all the cohorts tested and remained as an independent prognostic factor using multivariate analyses. When integrated with the clinical characteristics, the composite miRNA-clinical prognostic indicator showed improved prognostic performance. The miGISig also showed high accuracy in differentiating BC from healthy controls with the area under the receiver operating characteristics curve (ROC) with 0.915, 0.794 and 0.772 in GSE73002, GSE41922 and TCGA cohorts, respectively. 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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE73002, https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE41922).", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM1876422", "GSM1876423", "GSM1876424", "GSM1876425", "GSM1876426", "GSM1876427", "GSM1876428", "GSM1876429", "GSM1876430", "GSM1876431", "GSM1876432", "GSM1876433", "GSM1876434", "GSM1876435", "GSM1876436", "GSM1876437", "GSM1876438", "GSM1876439", "GSM1876440", "GSM1876441", "GSM1876442", "GSM1876443", "GSM1876444", "GSM1876445", "GSM1876446", "GSM1876447", "GSM1876448", "GSM1876449", "GSM1876450", "GSM1876451", "GSM1876452", "GSM1876453", "GSM1876454", "GSM1876455", "GSM1876456", "GSM1876457", "GSM1876458", "GSM1876459", "GSM1876460", "GSM1876461", "GSM1876462", "GSM1876463", "GSM1876464", "GSM1876465", "GSM1876466", "GSM1876467", "GSM1876468", "GSM1876469", "GSM1876470", "GSM1876471", "GSM1876472", "GSM1876473", "GSM1876474", "GSM1876475", "GSM1876476", "GSM1876477", "GSM1876478", 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"GSM1877402", "GSM1877403", "GSM1877404", "GSM1877405", "GSM1877406", "GSM1877407", "GSM1877408", "GSM1877409", "GSM1877410", "GSM1877411", "GSM1877412", "GSM1877413", "GSM1877414", "GSM1877415", "GSM1877416", "GSM1877417", "GSM1877418", "GSM1877419", "GSM1877420", "GSM1877421", "GSM1877422", "GSM1877423", "GSM1877424", "GSM1877425", "GSM1877426", "GSM1877427", "GSM1877428", "GSM1877429", "GSM1877430", "GSM1877431", "GSM1877432", "GSM1877433", "GSM1877434", "GSM1877435", "GSM1877436", "GSM1877437", "GSM1877438", "GSM1877439", "GSM1877440", "GSM1877441", "GSM1877442", "GSM1877443", "GSM1877444", "GSM1877445", "GSM1877446", "GSM1877447", "GSM1877448", "GSM1877449", "GSM1877450", "GSM1877451", "GSM1877452", "GSM1877453", "GSM1877454", "GSM1877455", "GSM1877456", "GSM1877457", "GSM1877458", "GSM1877459", "GSM1877460", "GSM1877461", "GSM1877462", "GSM1877463", "GSM1877464", "GSM1877465", "GSM1877466", "GSM1877467", "GSM1877468", "GSM1877469", "GSM1877470", "GSM1877471", "GSM1877472", "GSM1877473", "GSM1877474", "GSM1877475", "GSM1877476", "GSM1877477", "GSM1877478", "GSM1877479", "GSM1877480", "GSM1877481", "GSM1877482", "GSM1877483", "GSM1877484", "GSM1877485", "GSM1877486", "GSM1877487", "GSM1877488", "GSM1877489", "GSM1877490", "GSM1877491", "GSM1877492", "GSM1877493", "GSM1877494", "GSM1877495", "GSM1877496", "GSM1877497", "GSM1877498", "GSM1877499", "GSM1877500", "GSM1877501", "GSM1877502", "GSM1877503", "GSM1877504", "GSM1877505", "GSM1877506", "GSM1877507", "GSM1877508", "GSM1877509", "GSM1877510", "GSM1877511", "GSM1877512", "GSM1877513", "GSM1877514", "GSM1877515", "GSM1877516", "GSM1877517", "GSM1877518", "GSM1877519", "GSM1877520", "GSM1877521", "GSM1877522", "GSM1877523", "GSM1877524", "GSM1877525", "GSM1877526", "GSM1877527", "GSM1877528", "GSM1877529", "GSM1877530", "GSM1877531", "GSM1877532", "GSM1877533", "GSM1877534", "GSM1877535", "GSM1877536", "GSM1877537", "GSM1877538", "GSM1877539", "GSM1877540", "GSM1877541", "GSM1877542", "GSM1877543", "GSM1877544", "GSM1877545", "GSM1877546", "GSM1877547", "GSM1877548", "GSM1877549", "GSM1877550", "GSM1877551", "GSM1877552", "GSM1877553", "GSM1877554", "GSM1877555", "GSM1877556", "GSM1877557", "GSM1877558", "GSM1877559", "GSM1877560", "GSM1877561", "GSM1877562", "GSM1877563", "GSM1877564", "GSM1877565", "GSM1877566", "GSM1877567", "GSM1877568", "GSM1877569", "GSM1877570", "GSM1877571", "GSM1877572", "GSM1877573", "GSM1877574", "GSM1877575", "GSM1877576", "GSM1877577", "GSM1877578", "GSM1877579", "GSM1877580", "GSM1877581", "GSM1877582", "GSM1877583", "GSM1877584", "GSM1877585", "GSM1877586", "GSM1877587", "GSM1877588", "GSM1877589", "GSM1877590", "GSM1877591", "GSM1877592", "GSM1877593", "GSM1877594", "GSM1877595", "GSM1877596", "GSM1877597", "GSM1877598", "GSM1877599", "GSM1877600", "GSM1877601", "GSM1877602", "GSM1877603", "GSM1877604", "GSM1877605", "GSM1877606", "GSM1877607", "GSM1877608", "GSM1877609", "GSM1877610", "GSM1877611", "GSM1877612", "GSM1877613", "GSM1877614", "GSM1877615", "GSM1877616", "GSM1877617", "GSM1877618", "GSM1877619", "GSM1877620", "GSM1877621", "GSM1877622", "GSM1877623", "GSM1877624", "GSM1877625", "GSM1877626", "GSM1877627", "GSM1877628", "GSM1877629", "GSM1877630", "GSM1877631", "GSM1877632", "GSM1877633", "GSM1877634", "GSM1877635", "GSM1877636", "GSM1877637", "GSM1877638", "GSM1877639", "GSM1877640", "GSM1877641", "GSM1877642", "GSM1877643", "GSM1877644", "GSM1877645", "GSM1877646", "GSM1877647", "GSM1877648", "GSM1877649", "GSM1877650", "GSM1877651", "GSM1877652", "GSM1877653", "GSM1877654", "GSM1877655", "GSM1877656", "GSM1877657", "GSM1877658", "GSM1877659", "GSM1877660", "GSM1877661", "GSM1877662", "GSM1877663", "GSM1877664", "GSM1877665", "GSM1877666", "GSM1877667", "GSM1877668", "GSM1877669", "GSM1877670", "GSM1877671", "GSM1877672", "GSM1877673", "GSM1877674", "GSM1877675", "GSM1877676", "GSM1877677", "GSM1877678", "GSM1877679", "GSM1877680", "GSM1877681", "GSM1877682", "GSM1877683", "GSM1877684", "GSM1877685", "GSM1877686", "GSM1877687", "GSM1877688", "GSM1877689", "GSM1877690", "GSM1877691", "GSM1877692", "GSM1877693", "GSM1877694", "GSM1877695", "GSM1877696", "GSM1877697", "GSM1877698", "GSM1877699", "GSM1877700", "GSM1877701", "GSM1877702", "GSM1877703", "GSM1877704", "GSM1877705", "GSM1877706", "GSM1877707", "GSM1877708", "GSM1877709", "GSM1877710", "GSM1877711", "GSM1877712", "GSM1877713", "GSM1877714", "GSM1877715", "GSM1877716", "GSM1877717", "GSM1877718", "GSM1877719", "GSM1877720", "GSM1877721", "GSM1877722", "GSM1877723", "GSM1877724", "GSM1877725", "GSM1877726", "GSM1877727", "GSM1877728", "GSM1877729", "GSM1877730", "GSM1877731", "GSM1877732", "GSM1877733", "GSM1877734", "GSM1877735", "GSM1877736", "GSM1877737", "GSM1877738", "GSM1877739", "GSM1877740", "GSM1877741", "GSM1877742", "GSM1877743", "GSM1877744", "GSM1877745", "GSM1877746", "GSM1877747", "GSM1877748", "GSM1877749", "GSM1877750", "GSM1877751", "GSM1877752", "GSM1877753", "GSM1877754", "GSM1877755", "GSM1877756", "GSM1877757", "GSM1877758", "GSM1877759", "GSM1877760", "GSM1877761", "GSM1877762", "GSM1877763", "GSM1877764", "GSM1877765", "GSM1877766", "GSM1877767", "GSM1877768", "GSM1877769", "GSM1877770", "GSM1877771", "GSM1877772", "GSM1877773", "GSM1877774", "GSM1877775", "GSM1877776", "GSM1877777", "GSM1877778", "GSM1877779", "GSM1877780", "GSM1877781", "GSM1877782", "GSM1877783", "GSM1877784", "GSM1877785", "GSM1877786", "GSM1877787", "GSM1877788", "GSM1877789", "GSM1877790", "GSM1877791", "GSM1877792", "GSM1877793", "GSM1877794", "GSM1877795", "GSM1877796", "GSM1877797", "GSM1877798", "GSM1877799", "GSM1877800", "GSM1877801", "GSM1877802", "GSM1877803", "GSM1877804", "GSM1877805", "GSM1877806", "GSM1877807", "GSM1877808", "GSM1877809", "GSM1877810", "GSM1877811", "GSM1877812", "GSM1877813", "GSM1877814", "GSM1877815", "GSM1877816", "GSM1877817", "GSM1877818", "GSM1877819", "GSM1877820", "GSM1877821", "GSM1877822", "GSM1877823", "GSM1877824", "GSM1877825", "GSM1877826", "GSM1877827", "GSM1877828", "GSM1877829", "GSM1877830", "GSM1877831", "GSM1877832", "GSM1877833", "GSM1877834", "GSM1877835", "GSM1877836", "GSM1877837", "GSM1877838", "GSM1877839", "GSM1877840", "GSM1877841", "GSM1877842", "GSM1877843", "GSM1877844", "GSM1877845", "GSM1877846", "GSM1877847", "GSM1877848", "GSM1877849", "GSM1877850", "GSM1877851", "GSM1877852", "GSM1877853", "GSM1877854", "GSM1877855", "GSM1877856", "GSM1877857", "GSM1877858", "GSM1877859", "GSM1877860", "GSM1877861", "GSM1877862", "GSM1877863", "GSM1877864", "GSM1877865", "GSM1877866", "GSM1877867", "GSM1877868", "GSM1877869", "GSM1877870", "GSM1877871", "GSM1877872", "GSM1877873", "GSM1877874", "GSM1877875", "GSM1877876", "GSM1877877", "GSM1877878", "GSM1877879", "GSM1877880", "GSM1877881", "GSM1877882", "GSM1877883", "GSM1877884", "GSM1877885", "GSM1877886", "GSM1877887", "GSM1877888", "GSM1877889", "GSM1877890", "GSM1877891", "GSM1877892", "GSM1877893", "GSM1877894", "GSM1877895", "GSM1877896", "GSM1877897", "GSM1877898", "GSM1877899", "GSM1877900", "GSM1877901", "GSM1877902", "GSM1877903", "GSM1877904", "GSM1877905", "GSM1877906", "GSM1877907", "GSM1877908", "GSM1877909", "GSM1877910", "GSM1877911", "GSM1877912", "GSM1877913", "GSM1877914", "GSM1877915", "GSM1877916", "GSM1877917", "GSM1877918", "GSM1877919", "GSM1877920", "GSM1877921", "GSM1877922", "GSM1877923", "GSM1877924", "GSM1877925", "GSM1877926", "GSM1877927", "GSM1877928", "GSM1877929", "GSM1877930", "GSM1877931", "GSM1877932", "GSM1877933", "GSM1877934", "GSM1877935", "GSM1877936", "GSM1877937", "GSM1877938", "GSM1877939", "GSM1877940", "GSM1877941", "GSM1877942", "GSM1877943", "GSM1877944", "GSM1877945", "GSM1877946", "GSM1877947", "GSM1877948", "GSM1877949", "GSM1877950", "GSM1877951", "GSM1877952", "GSM1877953", "GSM1877954", "GSM1877955", "GSM1877956", "GSM1877957", "GSM1877958", "GSM1877959", "GSM1877960", "GSM1877961", "GSM1877962", "GSM1877963", "GSM1877964", "GSM1877965", "GSM1877966", "GSM1877967", "GSM1877968", "GSM1877969", "GSM1877970", "GSM1877971", "GSM1877972", "GSM1877973", "GSM1877974", "GSM1877975", "GSM1877976", "GSM1877977", "GSM1877978", "GSM1877979", "GSM1877980", "GSM1877981", "GSM1877982", "GSM1877983", "GSM1877984", "GSM1877985", "GSM1877986", "GSM1877987", "GSM1877988", "GSM1877989", "GSM1877990", "GSM1877991", "GSM1877992", "GSM1877993", "GSM1877994", "GSM1877995", "GSM1877996", "GSM1877997", "GSM1877998", "GSM1877999", "GSM1878000", "GSM1878001", "GSM1878002", "GSM1878003", "GSM1878004", "GSM1878005", "GSM1878006", "GSM1878007", "GSM1878008", "GSM1878009", "GSM1878010", "GSM1878011", "GSM1878012", "GSM1878013", "GSM1878014", "GSM1878015", "GSM1878016", "GSM1878017", "GSM1878018", "GSM1878019", "GSM1878020", "GSM1878021", "GSM1878022", "GSM1878023", "GSM1878024", "GSM1878025", "GSM1878026", "GSM1878027", "GSM1878028", "GSM1878029", "GSM1878030", "GSM1878031", "GSM1878032", "GSM1878033", "GSM1878034", "GSM1878035", "GSM1878036", "GSM1878037", "GSM1878038", "GSM1878039", "GSM1878040", "GSM1878041", "GSM1878042", "GSM1878043", "GSM1878044", "GSM1878045", "GSM1878046", "GSM1878047", "GSM1878048", "GSM1878049", "GSM1878050", "GSM1878051", "GSM1878052", "GSM1878053", "GSM1878054", "GSM1878055", "GSM1878056", "GSM1878057", "GSM1878058", "GSM1878059", "GSM1878060", "GSM1878061", "GSM1878062", "GSM1878063", "GSM1878064", "GSM1878065", "GSM1878066", "GSM1878067", "GSM1878068", "GSM1878069", "GSM1878070", "GSM1878071", "GSM1878072", "GSM1878073", "GSM1878074", "GSM1878075", "GSM1878076", "GSM1878077", "GSM1878078", "GSM1878079", "GSM1878080", "GSM1878081", "GSM1878082", "GSM1878083", "GSM1878084", "GSM1878085", "GSM1878086", "GSM1878087", "GSM1878088", "GSM1878089", "GSM1878090", "GSM1878091", "GSM1878092", "GSM1878093", "GSM1878094", "GSM1878095", "GSM1878096", "GSM1878097", "GSM1878098", "GSM1878099", "GSM1878100", "GSM1878101", "GSM1878102", "GSM1878103", "GSM1878104", "GSM1878105", "GSM1878106", "GSM1878107", "GSM1878108", "GSM1878109", "GSM1878110", "GSM1878111", "GSM1878112", "GSM1878113", "GSM1878114", "GSM1878115", "GSM1878116", "GSM1878117", "GSM1878118", "GSM1878119", "GSM1878120", "GSM1878121", "GSM1878122", "GSM1878123", "GSM1878124", "GSM1878125", "GSM1878126", "GSM1878127", "GSM1878128", "GSM1878129", "GSM1878130", "GSM1878131", "GSM1878132", "GSM1878133", "GSM1878134", "GSM1878135", "GSM1878136", "GSM1878137", "GSM1878138", "GSM1878139", "GSM1878140", "GSM1878141", "GSM1878142", "GSM1878143", "GSM1878144", "GSM1878145", "GSM1878146", "GSM1878147", "GSM1878148", "GSM1878149", "GSM1878150", "GSM1878151", "GSM1878152", "GSM1878153", "GSM1878154", "GSM1878155", "GSM1878156", "GSM1878157", "GSM1878158", "GSM1878159", "GSM1878160", "GSM1878161", "GSM1878162", "GSM1878163", "GSM1878164", "GSM1878165", "GSM1878166", "GSM1878167", "GSM1878168", "GSM1878169", "GSM1878170", "GSM1878171", "GSM1878172", "GSM1878173", "GSM1878174", "GSM1878175", "GSM1878176", "GSM1878177", "GSM1878178", "GSM1878179", "GSM1878180", "GSM1878181", "GSM1878182", "GSM1878183", "GSM1878184", "GSM1878185", "GSM1878186", "GSM1878187", "GSM1878188", "GSM1878189", "GSM1878190", "GSM1878191", "GSM1878192", "GSM1878193", "GSM1878194", "GSM1878195", "GSM1878196", "GSM1878197", "GSM1878198", "GSM1878199", "GSM1878200", "GSM1878201", "GSM1878202", "GSM1878203", "GSM1878204", "GSM1878205", "GSM1878206", "GSM1878207", "GSM1878208", "GSM1878209", "GSM1878210", "GSM1878211", "GSM1878212", "GSM1878213", "GSM1878214", "GSM1878215", "GSM1878216", "GSM1878217", "GSM1878218", "GSM1878219", "GSM1878220", "GSM1878221", "GSM1878222", "GSM1878223", "GSM1878224", "GSM1878225", "GSM1878226", "GSM1878227", "GSM1878228", "GSM1878229", "GSM1878230", "GSM1878231", "GSM1878232", "GSM1878233", "GSM1878234", "GSM1878235", "GSM1878236", "GSM1878237", "GSM1878238", "GSM1878239", "GSM1878240", "GSM1878241", "GSM1878242", "GSM1878243", "GSM1878244", "GSM1878245", "GSM1878246", "GSM1878247", "GSM1878248", "GSM1878249", "GSM1878250", "GSM1878251", "GSM1878252", "GSM1878253", "GSM1878254", "GSM1878255", "GSM1878256", "GSM1878257", "GSM1878258", "GSM1878259", "GSM1878260", "GSM1878261", "GSM1878262", "GSM1878263", "GSM1878264", "GSM1878265", "GSM1878266", "GSM1878267", "GSM1878268", "GSM1878269", "GSM1878270", "GSM1878271", "GSM1878272", "GSM1878273", "GSM1878274", "GSM1878275", "GSM1878276", "GSM1878277", "GSM1878278", "GSM1878279", "GSM1878280", "GSM1878281", "GSM1878282", "GSM1878283", "GSM1878284", "GSM1878285", "GSM1878286", "GSM1878287", "GSM1878288", "GSM1878289", "GSM1878290", "GSM1878291", "GSM1878292", "GSM1878293", "GSM1878294", "GSM1878295", "GSM1878296", "GSM1878297", "GSM1878298", "GSM1878299", "GSM1878300", "GSM1878301", "GSM1878302", "GSM1878303", "GSM1878304", "GSM1878305", "GSM1878306", "GSM1878307", "GSM1878308", "GSM1878309", "GSM1878310", "GSM1878311", "GSM1878312", "GSM1878313", "GSM1878314", "GSM1878315", "GSM1878316", "GSM1878317", "GSM1878318", "GSM1878319", "GSM1878320", "GSM1878321", "GSM1878322", "GSM1878323", "GSM1878324", "GSM1878325", "GSM1878326", "GSM1878327", "GSM1878328", "GSM1878329", "GSM1878330", "GSM1878331", "GSM1878332", "GSM1878333", "GSM1878334", "GSM1878335", "GSM1878336", "GSM1878337", "GSM1878338", "GSM1878339", "GSM1878340", "GSM1878341", "GSM1878342", "GSM1878343", "GSM1878344", "GSM1878345", "GSM1878346", "GSM1878347", "GSM1878348", "GSM1878349", "GSM1878350", "GSM1878351", "GSM1878352", "GSM1878353", "GSM1878354", "GSM1878355", "GSM1878356", "GSM1878357", "GSM1878358", "GSM1878359", "GSM1878360", "GSM1878361", "GSM1878362", "GSM1878363", "GSM1878364", "GSM1878365", "GSM1878366", "GSM1878367", "GSM1878368", "GSM1878369", "GSM1878370", "GSM1878371", "GSM1878372", "GSM1878373", "GSM1878374", "GSM1878375", "GSM1878376", "GSM1878377", "GSM1878378", "GSM1878379", "GSM1878380", "GSM1878381", "GSM1878382", "GSM1878383", "GSM1878384", "GSM1878385", "GSM1878386", "GSM1878387", "GSM1878388", "GSM1878389", "GSM1878390", "GSM1878391", "GSM1878392", "GSM1878393", "GSM1878394", "GSM1878395", 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"GSM1879177", "GSM1879178", "GSM1879179", "GSM1879180", "GSM1879181", "GSM1879182", "GSM1879183", "GSM1879184", "GSM1879185", "GSM1879186", "GSM1879187", "GSM1879188", "GSM1879189", "GSM1879190", "GSM1879191", "GSM1879192", "GSM1879193", "GSM1879194", "GSM1879195", "GSM1879196", "GSM1879197", "GSM1879198", "GSM1879199", "GSM1879200", "GSM1879201", "GSM1879202", "GSM1879203", "GSM1879204", "GSM1879205", "GSM1879206", "GSM1879207", "GSM1879208", "GSM1879209", "GSM1879210", "GSM1879211", "GSM1879212", "GSM1879213", "GSM1879214", "GSM1879215", "GSM1879216", "GSM1879217", "GSM1879218", "GSM1879219", "GSM1879220", "GSM1879221", "GSM1879222", "GSM1879223", "GSM1879224", "GSM1879225", "GSM1879226", "GSM1879227", "GSM1879228", "GSM1879229", "GSM1879230", "GSM1879231", "GSM1879232", "GSM1879233", "GSM1879234", "GSM1879235", "GSM1879236", "GSM1879237", "GSM1879238", "GSM1879239", "GSM1879240", "GSM1879241", "GSM1879242", "GSM1879243", "GSM1879244", "GSM1879245", "GSM1879246", "GSM1879247", "GSM1879248", "GSM1879249", "GSM1879250", "GSM1879251", "GSM1879252", "GSM1879253", "GSM1879254", "GSM1879255", "GSM1879256", "GSM1879257", "GSM1879258", "GSM1879259", "GSM1879260", "GSM1879261", "GSM1879262", "GSM1879263", "GSM1879264", "GSM1879265", "GSM1879266", "GSM1879267", "GSM1879268", "GSM1879269", "GSM1879270", "GSM1879271", "GSM1879272", "GSM1879273", "GSM1879274", "GSM1879275", "GSM1879276", "GSM1879277", "GSM1879278", "GSM1879279", "GSM1879280", "GSM1879281", "GSM1879282", "GSM1879283", "GSM1879284", "GSM1879285", "GSM1879286", "GSM1879287", "GSM1879288", "GSM1879289", "GSM1879290", "GSM1879291", "GSM1879292", "GSM1879293", "GSM1879294", "GSM1879295", "GSM1879296", "GSM1879297", "GSM1879298", "GSM1879299", "GSM1879300", "GSM1879301", "GSM1879302", "GSM1879303", "GSM1879304", "GSM1879305", "GSM1879306", "GSM1879307", "GSM1879308", "GSM1879309", "GSM1879310", "GSM1879311", "GSM1879312", "GSM1879313", "GSM1879314", "GSM1879315", "GSM1879316", "GSM1879317", "GSM1879318", "GSM1879319", "GSM1879320", "GSM1879321", "GSM1879322", "GSM1879323", "GSM1879324", "GSM1879325", "GSM1879326", "GSM1879327", "GSM1879328", "GSM1879329", "GSM1879330", "GSM1879331", "GSM1879332", "GSM1879333", "GSM1879334", "GSM1879335", "GSM1879336", "GSM1879337", "GSM1879338", "GSM1879339", "GSM1879340", "GSM1879341", "GSM1879342", "GSM1879343", "GSM1879344", "GSM1879345", "GSM1879346", "GSM1879347", "GSM1879348", "GSM1879349", "GSM1879350", "GSM1879351", "GSM1879352", "GSM1879353", "GSM1879354", "GSM1879355", "GSM1879356", "GSM1879357", "GSM1879358", "GSM1879359", "GSM1879360", "GSM1879361", "GSM1879362", "GSM1879363", "GSM1879364", "GSM1879365", "GSM1879366", "GSM1879367", "GSM1879368", "GSM1879369", "GSM1879370", "GSM1879371", "GSM1879372", "GSM1879373", "GSM1879374", "GSM1879375", "GSM1879376", "GSM1879377", "GSM1879378", "GSM1879379", "GSM1879380", "GSM1879381", "GSM1879382", "GSM1879383", "GSM1879384", "GSM1879385", "GSM1879386", "GSM1879387", "GSM1879388", "GSM1879389", "GSM1879390", "GSM1879391", "GSM1879392", "GSM1879393", "GSM1879394", "GSM1879395", "GSM1879396", "GSM1879397", "GSM1879398", "GSM1879399", "GSM1879400", "GSM1879401", "GSM1879402", "GSM1879403", "GSM1879404", "GSM1879405", "GSM1879406", "GSM1879407", "GSM1879408", "GSM1879409", "GSM1879410", "GSM1879411", "GSM1879412", "GSM1879413", "GSM1879414", "GSM1879415", "GSM1879416", "GSM1879417", "GSM1879418", "GSM1879419", "GSM1879420", "GSM1879421", "GSM1879422", "GSM1879423", "GSM1879424", "GSM1879425", "GSM1879426", "GSM1879427", "GSM1879428", "GSM1879429", "GSM1879430", "GSM1879431", "GSM1879432", "GSM1879433", "GSM1879434", "GSM1879435", "GSM1879436", "GSM1879437", "GSM1879438", "GSM1879439", "GSM1879440", "GSM1879441", "GSM1879442", "GSM1879443", "GSM1879444", "GSM1879445", "GSM1879446", "GSM1879447", "GSM1879448", "GSM1879449", "GSM1879450", "GSM1879451", "GSM1879452", "GSM1879453", "GSM1879454", "GSM1879455", "GSM1879456", "GSM1879457", "GSM1879458", "GSM1879459", "GSM1879460", "GSM1879461", "GSM1879462", "GSM1879463", "GSM1879464", "GSM1879465", "GSM1879466", "GSM1879467", "GSM1879468", "GSM1879469", "GSM1879470", "GSM1879471", "GSM1879472", "GSM1879473", "GSM1879474", "GSM1879475", "GSM1879476", "GSM1879477", "GSM1879478", "GSM1879479", "GSM1879480", "GSM1879481", "GSM1879482", "GSM1879483", "GSM1879484", "GSM1879485", "GSM1879486", "GSM1879487", "GSM1879488", "GSM1879489", "GSM1879490", "GSM1879491", "GSM1879492", "GSM1879493", "GSM1879494", "GSM1879495", "GSM1879496", "GSM1879497", "GSM1879498", "GSM1879499", "GSM1879500", "GSM1879501", "GSM1879502", "GSM1879503", "GSM1879504", "GSM1879505", "GSM1879506", "GSM1879507", "GSM1879508", "GSM1879509", "GSM1879510", "GSM1879511", "GSM1879512", "GSM1879513", "GSM1879514", "GSM1879515", "GSM1879516", "GSM1879517", "GSM1879518", "GSM1879519", "GSM1879520", "GSM1879521", "GSM1879522", "GSM1879523", "GSM1879524", "GSM1879525", "GSM1879526", "GSM1879527", "GSM1879528", "GSM1879529", "GSM1879530", "GSM1879531", "GSM1879532", "GSM1879533", "GSM1879534", "GSM1879535", "GSM1879536", "GSM1879537", "GSM1879538", "GSM1879539", "GSM1879540", "GSM1879541", "GSM1879542", "GSM1879543", "GSM1879544", "GSM1879545", "GSM1879546", "GSM1879547", "GSM1879548", "GSM1879549", "GSM1879550", "GSM1879551", "GSM1879552", "GSM1879553", "GSM1879554", "GSM1879555", "GSM1879556", "GSM1879557", "GSM1879558", "GSM1879559", "GSM1879560", "GSM1879561", "GSM1879562", "GSM1879563", "GSM1879564", "GSM1879565", "GSM1879566", "GSM1879567", "GSM1879568", "GSM1879569", "GSM1879570", "GSM1879571", "GSM1879572", "GSM1879573", "GSM1879574", "GSM1879575", "GSM1879576", "GSM1879577", "GSM1879578", "GSM1879579", "GSM1879580", "GSM1879581", "GSM1879582", "GSM1879583", "GSM1879584", "GSM1879585", "GSM1879586", "GSM1879587", "GSM1879588", "GSM1879589", "GSM1879590", "GSM1879591", "GSM1879592", "GSM1879593", "GSM1879594", "GSM1879595", "GSM1879596", "GSM1879597", "GSM1879598", "GSM1879599", "GSM1879600", "GSM1879601", "GSM1879602", "GSM1879603", "GSM1879604", "GSM1879605", "GSM1879606", "GSM1879607", "GSM1879608", "GSM1879609", "GSM1879610", "GSM1879611", "GSM1879612", "GSM1879613", "GSM1879614", "GSM1879615", "GSM1879616", "GSM1879617", "GSM1879618", "GSM1879619", "GSM1879620", "GSM1879621", "GSM1879622", "GSM1879623", "GSM1879624", "GSM1879625", "GSM1879626", "GSM1879627", "GSM1879628", "GSM1879629", "GSM1879630", "GSM1879631", "GSM1879632", "GSM1879633", "GSM1879634", "GSM1879635", "GSM1879636", "GSM1879637", "GSM1879638", "GSM1879639", "GSM1879640", "GSM1879641", "GSM1879642", "GSM1879643", "GSM1879644", "GSM1879645", "GSM1879646", "GSM1879647", "GSM1879648", "GSM1879649", "GSM1879650", "GSM1879651", "GSM1879652", "GSM1879653", "GSM1879654", "GSM1879655", "GSM1879656", "GSM1879657", "GSM1879658", "GSM1879659", "GSM1879660", "GSM1879661", "GSM1879662", "GSM1879663", "GSM1879664", "GSM1879665", "GSM1879666", "GSM1879667", "GSM1879668", "GSM1879669", "GSM1879670", "GSM1879671", "GSM1879672", "GSM1879673", "GSM1879674", "GSM1879675", "GSM1879676", "GSM1879677", "GSM1879678", "GSM1879679", "GSM1879680", "GSM1879681", "GSM1879682", "GSM1879683", "GSM1879684", "GSM1879685", "GSM1879686", "GSM1879687", "GSM1879688", "GSM1879689", "GSM1879690", "GSM1879691", "GSM1879692", "GSM1879693", "GSM1879694", "GSM1879695", "GSM1879696", "GSM1879697", "GSM1879698", "GSM1879699", "GSM1879700", "GSM1879701", "GSM1879702", "GSM1879703", "GSM1879704", "GSM1879705", "GSM1879706", "GSM1879707", "GSM1879708", "GSM1879709", "GSM1879710", "GSM1879711", "GSM1879712", "GSM1879713", "GSM1879714", "GSM1879715", "GSM1879716", "GSM1879717", "GSM1879718", "GSM1879719", "GSM1879720", "GSM1879721", "GSM1879722", "GSM1879723", "GSM1879724", "GSM1879725", "GSM1879726", "GSM1879727", "GSM1879728", "GSM1879729", "GSM1879730", "GSM1879731", "GSM1879732", "GSM1879733", "GSM1879734", "GSM1879735", "GSM1879736", "GSM1879737", "GSM1879738", "GSM1879739", "GSM1879740", "GSM1879741", "GSM1879742", "GSM1879743", "GSM1879744", "GSM1879745", "GSM1879746", "GSM1879747", "GSM1879748", "GSM1879749", "GSM1879750", "GSM1879751", "GSM1879752", "GSM1879753", "GSM1879754", "GSM1879755", "GSM1879756", "GSM1879757", "GSM1879758", "GSM1879759", "GSM1879760", "GSM1879761", "GSM1879762", "GSM1879763", "GSM1879764", "GSM1879765", "GSM1879766", "GSM1879767", "GSM1879768", "GSM1879769", "GSM1879770", "GSM1879771", "GSM1879772", "GSM1879773", "GSM1879774", "GSM1879775", "GSM1879776", "GSM1879777", "GSM1879778", "GSM1879779", "GSM1879780", "GSM1879781", "GSM1879782", "GSM1879783", "GSM1879784", "GSM1879785", "GSM1879786", "GSM1879787", "GSM1879788", "GSM1879789", "GSM1879790", "GSM1879791", "GSM1879792", "GSM1879793", "GSM1879794", "GSM1879795", "GSM1879796", "GSM1879797", "GSM1879798", "GSM1879799", "GSM1879800", "GSM1879801", "GSM1879802", "GSM1879803", "GSM1879804", "GSM1879805", "GSM1879806", "GSM1879807", "GSM1879808", "GSM1879809", "GSM1879810", "GSM1879811", "GSM1879812", "GSM1879813", "GSM1879814", "GSM1879815", "GSM1879816", "GSM1879817", "GSM1879818", "GSM1879819", "GSM1879820", "GSM1879821", "GSM1879822", "GSM1879823", "GSM1879824", "GSM1879825", "GSM1879826", "GSM1879827", "GSM1879828", "GSM1879829", "GSM1879830", "GSM1879831", "GSM1879832", "GSM1879833", "GSM1879834", "GSM1879835", "GSM1879836", "GSM1879837", "GSM1879838", "GSM1879839", "GSM1879840", "GSM1879841", "GSM1879842", "GSM1879843", "GSM1879844", "GSM1879845", "GSM1879846", "GSM1879847", "GSM1879848", "GSM1879849", "GSM1879850", "GSM1879851", "GSM1879852", "GSM1879853", "GSM1879854", "GSM1879855", "GSM1879856", "GSM1879857", "GSM1879858", "GSM1879859", "GSM1879860", "GSM1879861", "GSM1879862", "GSM1879863", "GSM1879864", "GSM1879865", "GSM1879866", "GSM1879867", "GSM1879868", "GSM1879869", "GSM1879870", "GSM1879871", "GSM1879872", "GSM1879873", "GSM1879874", "GSM1879875", "GSM1879876", "GSM1879877", "GSM1879878", "GSM1879879", "GSM1879880", "GSM1879881", "GSM1879882", "GSM1879883", "GSM1879884", "GSM1879885", "GSM1879886", "GSM1879887", "GSM1879888", "GSM1879889", "GSM1879890", "GSM1879891", "GSM1879892", "GSM1879893", "GSM1879894", "GSM1879895", "GSM1879896", "GSM1879897", "GSM1879898", "GSM1879899", "GSM1879900", "GSM1879901", "GSM1879902", "GSM1879903", "GSM1879904", "GSM1879905", "GSM1879906", "GSM1879907", "GSM1879908", "GSM1879909", "GSM1879910", "GSM1879911", "GSM1879912", "GSM1879913", "GSM1879914", "GSM1879915", "GSM1879916", "GSM1879917", "GSM1879918", "GSM1879919", "GSM1879920", "GSM1879921", "GSM1879922", "GSM1879923", "GSM1879924", "GSM1879925", "GSM1879926", "GSM1879927", "GSM1879928", "GSM1879929", "GSM1879930", "GSM1879931", "GSM1879932", "GSM1879933", "GSM1879934", "GSM1879935", "GSM1879936", "GSM1879937", "GSM1879938", "GSM1879939", "GSM1879940", "GSM1879941", "GSM1879942", "GSM1879943", "GSM1879944", "GSM1879945", "GSM1879946", "GSM1879947", "GSM1879948", "GSM1879949", "GSM1879950", "GSM1879951", "GSM1879952", "GSM1879953", "GSM1879954", "GSM1879955", "GSM1879956", "GSM1879957", "GSM1879958", "GSM1879959", "GSM1879960", "GSM1879961", "GSM1879962", "GSM1879963", "GSM1879964", "GSM1879965", "GSM1879966", "GSM1879967", "GSM1879968", "GSM1879969", "GSM1879970", "GSM1879971", "GSM1879972", "GSM1879973", "GSM1879974", "GSM1879975", "GSM1879976", "GSM1879977", "GSM1879978", "GSM1879979", "GSM1879980", "GSM1879981", "GSM1879982", "GSM1879983", "GSM1879984", "GSM1879985", "GSM1879986", "GSM1879987", "GSM1879988", "GSM1879989", "GSM1879990", "GSM1879991", "GSM1879992", "GSM1879993", "GSM1879994", "GSM1879995", "GSM1879996", "GSM1879997", "GSM1879998", "GSM1879999", "GSM1880000", "GSM1880001", "GSM1880002", "GSM1880003", "GSM1880004", "GSM1880005", "GSM1880006", "GSM1880007", "GSM1880008", "GSM1880009", "GSM1880010", "GSM1880011", "GSM1880012", "GSM1880013", "GSM1880014", "GSM1880015", "GSM1880016", "GSM1880017", "GSM1880018", "GSM1880019", "GSM1880020", "GSM1880021", "GSM1880022", "GSM1880023", "GSM1880024", "GSM1880025", "GSM1880026", "GSM1880027", "GSM1880028", "GSM1880029", "GSM1880030", "GSM1880031", "GSM1880032", "GSM1880033", "GSM1880034", "GSM1880035", "GSM1880036", "GSM1880037", "GSM1880038", "GSM1880039", "GSM1880040", "GSM1880041", "GSM1880042", "GSM1880043", "GSM1880044", "GSM1880045", "GSM1880046", "GSM1880047", "GSM1880048", "GSM1880049", "GSM1880050", "GSM1880051", "GSM1880052", "GSM1880053", "GSM1880054", "GSM1880055", "GSM1880056", "GSM1880057", "GSM1880058", "GSM1880059", "GSM1880060", "GSM1880061", "GSM1880062", "GSM1880063", "GSM1880064", "GSM1880065", "GSM1880066", "GSM1880067", "GSM1880068", "GSM1880069", "GSM1880070", "GSM1880071", "GSM1880072", "GSM1880073", "GSM1880074", "GSM1880075", "GSM1880076", "GSM1880077", "GSM1880078", "GSM1880079", "GSM1880080", "GSM1880081", "GSM1880082", "GSM1880083", "GSM1880084", "GSM1880085", "GSM1880086", "GSM1880087", "GSM1880088", "GSM1880089", "GSM1880090", "GSM1880091", "GSM1880092", "GSM1880093", "GSM1880094", "GSM1880095", "GSM1880096", "GSM1880097", "GSM1880098", "GSM1880099", "GSM1880100", "GSM1880101", "GSM1880102", "GSM1880103", "GSM1880104", "GSM1880105", "GSM1880106", "GSM1880107", "GSM1880108", "GSM1880109", "GSM1880110", "GSM1880111", "GSM1880112", "GSM1880113", "GSM1880114", "GSM1880115", "GSM1880116", "GSM1880117", "GSM1880118", "GSM1880119", "GSM1880120", "GSM1880121", "GSM1880122", "GSM1880123", "GSM1880124", "GSM1880125", "GSM1880126", "GSM1880127", "GSM1880128", "GSM1880129", "GSM1880130", "GSM1880131", "GSM1880132", "GSM1880133", "GSM1880134", "GSM1880135", "GSM1880136", "GSM1880137", "GSM1880138", "GSM1880139", "GSM1880140", "GSM1880141", "GSM1880142", "GSM1880143", "GSM1880144", "GSM1880145", "GSM1880146", "GSM1880147", "GSM1880148", "GSM1880149", "GSM1880150", "GSM1880151", "GSM1880152", "GSM1880153", "GSM1880154", "GSM1880155", "GSM1880156", "GSM1880157", "GSM1880158", "GSM1880159", "GSM1880160", "GSM1880161", "GSM1880162", "GSM1880163", "GSM1880164", "GSM1880165", "GSM1880166", "GSM1880167", "GSM1880168", "GSM1880169", "GSM1880170", "GSM1880171", "GSM1880172", "GSM1880173", "GSM1880174", "GSM1880175", "GSM1880176", "GSM1880177", "GSM1880178", "GSM1880179", "GSM1880180", "GSM1880181", "GSM1880182", "GSM1880183", "GSM1880184", "GSM1880185", "GSM1880186", "GSM1880187", "GSM1880188", "GSM1880189", "GSM1880190", "GSM1880191", "GSM1880192", "GSM1880193", "GSM1880194", "GSM1880195", "GSM1880196", "GSM1880197", "GSM1880198", "GSM1880199", "GSM1880200", "GSM1880201", "GSM1880202", "GSM1880203", "GSM1880204", "GSM1880205", "GSM1880206", "GSM1880207", "GSM1880208", "GSM1880209", "GSM1880210", "GSM1880211", "GSM1880212", "GSM1880213", "GSM1880214", "GSM1880215", "GSM1880216", "GSM1880217", "GSM1880218", "GSM1880219", "GSM1880220", "GSM1880221", "GSM1880222", "GSM1880223", "GSM1880224", "GSM1880225", "GSM1880226", "GSM1880227", "GSM1880228", "GSM1880229", "GSM1880230", "GSM1880231", "GSM1880232", "GSM1880233", "GSM1880234", "GSM1880235", "GSM1880236", "GSM1880237", "GSM1880238", "GSM1880239", "GSM1880240", "GSM1880241", 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