In Silico Identification of Contradictory Role of ADAMTS5 in Hepatocellular Carcinoma.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:33522433", "kind": "science-record", "revision": 4, "content_hash": "sha256:d54bbb21bdb5800865450feaa82d13362e4517d165e2835a51777d896eb3e1ec", "created_at": "2026-11-01T15:41:24Z", "updated_at": "2026-11-01T21:24:35Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "In Silico Identification of Contradictory Role of ADAMTS5 in Hepatocellular Carcinoma.", "doi": "10.1177/1533033820986826", "pmid": "33522433", "authors": ["Zhipeng Zhu", "Jiuhua Xu", "Xiaofang Wu", "Sihao Lin", "Lulu Li", "Weipeng Ye", "Zhengjie Huang"], "journal": "Technology in cancer research & treatment", "year": 2021, "abstract": "BACKGROUND: ADAMTS5 has different roles in multiple types of cancers and participates in various molecular mechanisms. However, the prognostic value of ADAMTS5 in patients with hepatocellular carcinoma (HCC) still remains unclear. We carried the study to evaluate the prognostic value and identified underlying molecular mechanisms in HCC.\nMETHODS: Firstly, the association of ADAMTS5 expression and clinicopathological parameters was evaluated by in GSE14520. Next, ADAMTS5 expression in HCC was performed using GSE14520, GSE36376, GSE76427 and The Cancer Genome Atlas (TCGA) profile. Furthermore, Kaplan-Meier analysis, Univariate and Multivariate Cox regression analysis, subgroup analysis was performed to evaluate the prognostic value of ADAMTS5 in HCC. Finally, GO enrichment analysis, gene set enrichment analysis (GSEA) and weighted gene co-expression network analysis (WGCNA) were performed to revealed underlying molecular mechanisms.\nRESULT: The expression of ADAMTS5 was positively correlated with the development of HCC. Next, high ADAMTS5 expression was significantly associated with poorer survival (all P < 0.05) and the impact of ADAMTS5 on all overall survival (OS), disease-free survival (DFS), relapse-free survival (RFS), disease specific survival (DSS) and progression free interval (PFI) was specific for HCC among other 29 cancer types. Subgroup analysis showed that ADAMTS5 overexpression was significantly associated with poorer OS in patients with HCC. Finally, ADAMTS5 might participate in the status conversion from metabolic-dominant to extracellular matrix-dominant, and the activation of ECM-related biological process might contribute to high higher mortality risk for patients with HCC.\nCONCLUSION: ADAMTS5 may play an important role in the progression of HCC, and may be considered as a novel and effective biomarker for predicting prognosis for patients with HCC.", "claims": [{"id": "claim-data-access", "statement": "GEO and TCGA databases is publicly available and open-access, and do not involve animal experiments and human specimens, ethical approval was not necessary.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:33522433", "locator": "sections[12] \"fn-group\" paragraph 1", "quote": "GEO and TCGA databases is publicly available and open-access, and do not involve animal experiments and human specimens, ethical approval was not necessary."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": null, "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:33522433"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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