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pmid:33649342
Development of a poor-prognostic-mutations derived immune prognostic model for acute myeloid leukemia.
Feng-Ting Dao · Jun Wang · Lu Yang · Ya-Zhen Qin
Scientific reports · 2021 doi:10.1038/s41598-021-84190-0
Paper
complete
Experiment
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Data
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Analysis
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Execution
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Complete file
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In addition, since the immune microenvironment might influence prognosis and somatic mutations have been demonstrated to modulate the immune microenvironment in AML, there is need for developing and evaluating an immune prognostic model (IPM) derived from mutations associated with poor prognosis. Based on AML cases with intermediate and adverse-cytogenetic risk in the Cancer Genome Atlas (TCGA) database, 64 immune-related differentially expressed genes (DEGs) among patients with RUNX1, TP53, or ASXL1 mutations and patients without these mutations were identified. After Cox proportional hazards analysis, an IPM composed of PYCARD and PEAR1 genes was constructed. IPM defined high-risk (IPM-HR) independently predicted lower 2-year overall survival (OS) rates in both patients with intermediate and adverse-cytogenetic risks and non-M3 patients in the TCGA AML cohort. 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null, "group_sizes_basis": null, "platform": "570;96;97", "taxon": "Homo sapiens", "title": "Prognostic gene signature for AML", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE71014", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE71014", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE71014", "version": null, "note": "The somatic mutation status (workflow type: VarScan2 Variant Aggregation and Masking), transcriptional profiles, and the corresponding clinical and overall survival (OS) data of 173 AML patients were downloaded from The Cancer Genome Atlas (TCGA) database (https://portal.gdc.cancer.gov/).", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The somatic mutation status (workflow type: VarScan2 Variant Aggregation and Masking), transcriptional profiles, and the corresponding clinical and overall survival (OS) data of 173 AML patients were downloaded from The Cancer Genome Atlas (TCGA) database (https://portal.gdc.cancer.gov/).", "access_statement_kind": "repository_route_statement", "sample_accessions": ["GSM1825455", "GSM1825456", "GSM1825457", "GSM1825458", "GSM1825459", "GSM1825460", "GSM1825461", "GSM1825462", "GSM1825463", "GSM1825464", "GSM1825465", "GSM1825466", "GSM1825467", "GSM1825468", "GSM1825469", "GSM1825470", "GSM1825471", "GSM1825472", "GSM1825473", "GSM1825474", "GSM1825475", "GSM1825476", "GSM1825477", "GSM1825478", "GSM1825479", "GSM1825480", "GSM1825481", "GSM1825482", "GSM1825483", "GSM1825484", "GSM1825485", "GSM1825486", "GSM1825487", "GSM1825488", "GSM1825489", "GSM1825490", "GSM1825491", "GSM1825492", "GSM1825493", "GSM1825494", 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"Homo sapiens", "title": "An mRNA Expression Signature for Prognostication in De Novo Acute Myeloid Leukemia Patients with Normal Karyotype", "resolution_checked_at": "2026-11-01T15:39:55Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "asset:table:pmid:33649342:1", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:801f57dc005af3a454e0be38f6fbe1f9f6a5f81a878ab9525a2ab3d04625a022", "bytes": 1130, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[7]/table-wrap[1]#Tab1", "version": null, "note": "Independent prognostic factors for OS of AML patients in TCGA cohort.", "structure": {"pmcid": "PMC7921432", "section_index": 7, "section_title": "IPM-defined risk independently predicted poor outcomes in the TCGA cohort", "row_count": 17, "column_count": 7}, "table": {"label": "Table 1", "caption": "Independent prognostic factors for OS of AML patients in TCGA cohort.", "rows": [["", "AML patients with intermediate and adverse-cytogenetic risk", "Non-M3 AML patients"], ["No. of patients", "HR(95%CI)", "P value", "No. of patients", "HR(95%CI)", "P value"], ["IPM", "", "", "", "", "", ""], ["IPM-LR", "87", "1.00", "< 0.0001", "104", "1.00", "< 0.0001"], ["IPM-HR", "20", "3.22 (1.71–6.05)", "22", "3.40 (1.84–6.27)"], ["Age", "", "", "", "", "", ""], ["Age < 60y", "52", "1.00", "0.040", "60", "1.00", "0.030"], ["Age ≥ 60y", "55", "1.71 (1.03–2.85)", "66", "1.72 (1.06–2.81)"], ["TP53", "", "", "", "", "", ""], ["Wild type", "97", "1.00", "0.001", "114", "1.00", "< 0.0001"], ["Mutation", "10", "4.05 (1.82–9.0)", "10", "4.26 (2.0–9.06)"], ["FLT3-ITD", "", "", "", "", "", ""], ["( −)", "86", "1.00", "0.033", "99", "1.00", "0.027"], ["( +)", "21", "1.94 (1.06–3.58)", "25", "1.95 (1.08–3.52)"], ["DNMT3A", "", "", "", "", "", ""], ["Wild type", "74", "1.00", "0.006", 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