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pmid:33717423

Identification and validation of a prognostic signature and combination drug therapy for immunotherapy of head and neck squamous cell carcinoma

Computational and Structural Biotechnology Journal · 2021 doi:10.1016/j.csbj.2021.01.046

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Record details sci_version · id · kind · revision · content_hash · schema · created_at · updated_at · generator
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pmid:33717423
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science-record
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title
Identification and validation of a prognostic signature and combination drug therapy for immunotherapy of head and neck squamous cell carcinoma
doi
10.1016/j.csbj.2021.01.046
pmid
33717423
authors
null
journal
Computational and Structural Biotechnology Journal
year
2021
abstract
null
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the hazard ratio for survival associated with the prognostic signature in head and neck squamous cell carcinoma
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the hazard ratio for survival associated with the prognostic signature in head and neck squamous cell carcinoma
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Univariate and multivariate Cox regression analyses of IRGPI and other clinicopathological factors for OS in entire TCGA cohort and GSE65858 cohort.
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Relationship between IRGPI and patient prognosis
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Table 1
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Univariate and multivariate Cox regression analyses of IRGPI and other clinicopathological factors for OS in entire TCGA cohort and GSE65858 cohort.
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Overall survival
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1.011
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0.993–1.028
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0.228
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1.011
[5]
0.992–1.030
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0.259
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0.185
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0.705
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0.463–1.074
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0.103
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6.242–13.947
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[5]
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0.695–1.299
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0.801–2.001
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0.002
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0.954
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0.721–1.262
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0.740
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0.275
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[3]
0.002
[4]
2.254
[5]
0.907–5.599
[6]
0.080
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1.739
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1.186–2.552
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0.005
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1.815
[5]
1.219–2.702
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Potential targeted therapeutic drugs for IRGPI based on CMap analysis.
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Screening of small-molecule drugs
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Potential targeted therapeutic drugs for IRGPI based on CMap analysis.
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100
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0.02233
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0.0236
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80
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0.01239
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0.0191
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75
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0.03032
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0.1754
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0.00638
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0.0051
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83
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0.02637
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0.0423
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80
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[3]
−0.631
[4]
0.04518
[5]
0.0148
[6]
75
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Dihydroergocristine
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−0.449
[2]
4
[3]
−0.74
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0.00897
[5]
0.0308
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75
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Vorinostat
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12
[3]
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0.00068
[5]
0.3097
[6]
66
[16] array · 7 items
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4
[3]
−0.688
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0.02039
[5]
0.0921
[6]
75
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Levonorgestrel
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[2]
6
[3]
−0.525
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0.04676
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0.1913
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66
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4
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−0.651
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0.03503
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0.057
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75
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4
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0.02103
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0.1304
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75
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5
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0.03507
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0.0622
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80
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5
[3]
−0.614
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0.02357
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0.0263
[6]
60
[22] array · 7 items
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22
[3]
−0.342
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0.00826
[5]
0.1397
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50
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18
[3]
−0.321
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0.04013
[5]
0.3758
[6]
50
[24] array · 7 items
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Trichostatin A
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−0.264
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182
[3]
−0.441
[4]
0
[5]
0.2772
[6]
51
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Etilefrine
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4
[3]
−0.653
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0.03428
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0.0426
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50
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Cyanocobalamin
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4
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0.03945
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0.0432
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50
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4
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−0.657
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0.03191
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0.0986
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50
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The results of molecular docking.
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Molecular docking
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The results of molecular docking.
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Pubchem CID
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Glide gscore
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1
[1]
31703
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Doxorubicin
[3]
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Daunorubicin
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Etilefrine
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Dihydroergocristine
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6047
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Levodopa
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Norfloxacin
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Doxycycline
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Camptothecin
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4855
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Piromidic Acid
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10
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5311498
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Cyanocobalamin
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137349240
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quote
Among these DEIRGs, the prognosis-related IRGs were identified and subjected to subsequent analysis. Firstly, the univariate Cox proportional hazard regression model was used to analyze the correlation between DEIRGs and overall survival (OS) in the training set, followed by the Least Absolute Shrinkage and Selection Operator (LASSO) penalized Cox proportional hazards regression for selecting the optimal subset of prognosis-related IRGs [17]. The risk score was then calculated using expression data multiplied by the regression coefficient from the LASSO regression model. The formula was as follows: risk score = [Expression level of Gene 1 * coefficient] + [Expression level of Gene 2 * coefficient] + … + [Expression level of Gene n * coefficient]. Patients were additionally separated into high- and low- risk groups according to the median value of risk score.
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source:pmid:33717423
[1]
asset:table:pmid:33717423:1
[2]
asset:table:pmid:33717423:2
[3]
asset:table:pmid:33717423:3
steps array · 1 item
[0]
read_published_estimate
must_build object · 5 fields
dsl_operations array · 0 items
converters array · 0 items
readers array · 2 items
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unknown
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xml
capabilities array · 0 items
data_gaps array · 4 items
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source:pmid:33717423
[1]
materials:the source data behind pmid:33717423, which the paper says are available from the authors on request
[2]
materials:the analysis programme that recomputes the published estimate
[3]
data:availability
gaps array · 1 item
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method:not_determinable
review object · 5 fields
state
partial
machine_critique object · 7 fields
status
blocked
providers array · 1 item
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minimax-m3-1-flash
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prompt_version
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raw_response_chars
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target_providers array · 2 items
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provider
minimax-m3-1-flash
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prompt_version
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prompt_hash
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raw_response
{"parent_value":0,"unit":"","evidence":"","target_result":"The text states that IRGPI was significantly associated with overall survival and could be used as an independent prognostic predictor, but it does not state a numerical hazard ratio for the registered target.","number_stated":false}
reading object · 6 fields
parent_value
0
unit
evidence
target_result
The text states that IRGPI was significantly associated with overall survival and could be used as an independent prognostic predictor, but it does not state a numerical hazard ratio for the registered target.
number_stated
false
source_locator
null
recorded_at
2026-10-31T14:34:53.970226+00:00
[1] object · 8 fields
provider
minimax-m3
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prompt_hash
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source_hash
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raw_response
{"parent_value":0,"unit":"","evidence":"","target_result":"The supplied text states that IRGPI was significantly associated with overall survival in univariate and multivariate analyses in the entire TCGA cohort and the GSE65858 cohort, and could be used as an independent prognostic predictor. Although hazard ratios are reported in Table 1, no numerical hazard ratio for IRGPI is included in the supplied text.","number_stated":false}
reading object · 6 fields
parent_value
0
unit
evidence
target_result
The supplied text states that IRGPI was significantly associated with overall survival in univariate and multivariate analyses in the entire TCGA cohort and the GSE65858 cohort, and could be used as an independent prognostic predictor. Although hazard ratios are reported in Table 1, no numerical hazard ratio for IRGPI is included in the supplied text.
number_stated
false
source_locator
null
recorded_at
2026-10-31T14:35:11.533984+00:00
agreement
false
disagreements array · 0 items
agreement_basis object · 3 fields
policy
decisive_fields
decisive_fields array · 4 items
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number_stated
[1]
parent_value
[2]
unit
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work_type
advisory_fields array · 0 items
blinded
true
human_critique object · 5 fields
status
not_run
reviewer
null
signed_at
null
conflict_checked
false
commentary
null
stages array · 7 items
[0] object · 4 fields
key
target_materials
status
pending
reason
null
evidence
null
[1] object · 4 fields
key
independent_readings
status
blocked
reason
The reading stage and the target extraction did not both return two readings, so the package claims no agreement.
evidence object · 1 field
provider_errors array · 1 item
[0] object · 3 fields
provider
minimax-m3
model
MiniMax-M3
reason
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[2] object · 4 fields
key
source_resolution
status
pending
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null
evidence
null
[3] object · 4 fields
key
protocol_reconstruction
status
pending
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null
evidence
null
[4] object · 4 fields
key
control_execution
status
pending
reason
null
evidence
null
[5] object · 4 fields
key
control_comparison
status
pending
reason
null
evidence
null
[6] object · 4 fields
key
publication
status
pending
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null
evidence
null
gaps array · 2 items
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review.human_critique
[1]
review.machine_critique.blocked
execution object · 5 fields
state
absent
status
not_run
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runs array · 0 items
gaps array · 1 item
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execution.not_run
provenance object · 7 fields
entities array · 1 item
[0] object · 3 fields
id
package:814c93eae493214cdd0d25599dcd743fe00cc008e22daba8633027010b343b3a
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sep_package
label
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activities array · 1 item
[0] object · 4 fields
id
activity:conversion:pmid:33717423
type
conversion
used array · 1 item
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package:814c93eae493214cdd0d25599dcd743fe00cc008e22daba8633027010b343b3a
agent
agent:corpus-assay-engine
agents array · 2 items
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id
agent:minimax-m3-1-flash
type
model
label
minimax-m3-1-flash
[1] object · 3 fields
id
agent:corpus-assay-engine
type
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source_run_id
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dsl_catalogue_fingerprint
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capability_table_fingerprint
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snapshot_id
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lineage object · 4 fields
parent_id
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gaps array · 15 items
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asset:data:availability not verified
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asset:materials:the analysis programme that recomputes the published estimate not verified
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review.human_critique
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review.machine_critique.blocked
[12]
step:obtain_source_data blocked on data:accession_absent
[13]
step:run_analysis blocked on method:differential_expression_limma_voom
[14]
targets
Complete file
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