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pmid:33732694
Clinical Significance of a Novel Tumor Progression-Associated Immune Signature in Colorectal Adenocarcinoma.
Rui Mao · Fan Yang · Zheng Wang · Chenxin Xu · Qian Liu · Yanjun Liu · Tongtong Zhang
Frontiers in cell and developmental biology · 2021 doi:10.3389/fcell.2021.625212
Paper
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Experiment
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Data
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Analysis
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Execution
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Complete file
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There is an urgent need for efficient screening criteria to identify patients who tend to relapse in order to treat them earlier and more systematically.\nMETHODS: We identified two groups of patients with significantly different outcomes by unsupervised cluster analysis of GSE39582 based on 101 significantly differentially expressed immune genes. To develop an accurate and specific signature based on immune-related genes to predict the recurrence of CRC, a multivariate Cox risk regression model was constructed with a training cohort composed of 519 CRC samples. The model was then validated using 129, 292, and 446 samples in the real-time quantitative reverse transcription PCR (qRT-PCR), test, and validation cohorts, respectively.\nRESULTS: This classification system can also be used to predict the prognosis in clinical subgroups and patients with different mutation states. Four independent datasets, including qRT-PCR and The Cancer Genome Atlas (TCGA), demonstrated that they can also be used to accurately predict the overall survival of CRC patients. Further analysis suggested that high-risk patients were characterized by worse effects of chemotherapy and immunotherapy, as well as lower immune scores. 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multivariable Cox regression analysis of IGBRS and characteristics with RFS and OS in GSE39582.", "rows": [["Variable", "Relapse-free survival", "Overall survival"], ["", "Univariate cox", "Multivariate cox", "Univariate cox", "Multivariate cox"], ["", "p-value", "HR", "95% CI", "p-value", "HR", "95% CI", "p-value", "HR", "95% CI", "p-value", "HR", "95% CI"], ["Age", "", "", "", "", "", "", "", "", "", "", "", ""], [">65 Vs. ≤65 (reference)", "0.9150", "1.0180", "0.7296–1.4210", "0.4706", "1.5273", "0.8056–1.6270", "0.0138", "1.4620", "1.0800–1.9780", "<0.0001", "1.7394", "1.2626–2.3960"], ["Sex", "", "", "", "", "", "", "", "", "", "", "", ""], ["Male Vs. female (reference)", "0.1410", "1.2840", "0.9206–1.7900", "0.0968", "0.9815", "0.9482–1.9160", "0.0684", "1.3100", "0.9799–1.7500", "0.0758", "1.3111", "0.9722–1.7680"], ["TNM stage", "", "", "", "", "", "", "", "", "", "", "", ""], ["I (reference)", "", "", "", "", "", "", "", "", "", "", "", ""], ["II", "0.0393", "7.9980", "1.1070–57.7800", "0.0814", "5.8670", "0.7998–42.6740", "0.2980", "1.5550", "0.6772–3.5700", "0.4615", "1.3804", "0.5853–3.2560"], ["III", "0.0054", "16.3930", "2.2810–117.8100", "0.0239", "10.1700", "1.3776–73.1500", "0.1280", "1.9130", "0.8299–4.4120", "0.2490", "1.6627", "0.7005–3.9460"], ["IV", "0.0091", "15.3930", "1.9900–127.5000", "0.0178", "12.7800", "1.5563–103.7330", "<0.0001", "7.8110", "3.3021–18.4750", "<0.0001", "7.1807", "2.9121–17.060"], ["Location", "", "", "", "", "", "", "", "", "", "", "", ""], ["Proximal vs. distal (reference)", "0.8416", "0.3200", "0.5993–1.1820", "0.2340", "0.7871", "0.5333–1.1690", "0.6510", "1.0700", "0.7988–1.4320", "0.9041", "1.0206", "0.7323–1.4230"], ["MMR status", "", "", "", "", "", "", "", "", "", "", "", ""], ["dMMR Vs. pMMR (reference)", "0.0112", "0.4345", "0.2282–0.8272", "0.6168", "0.8076", "0.3498–1.8600", "0.3038", "0.7739", "0.4748–1.2610", "0.6928", "1.1328", "0.6103–2.1020"], ["CIMP", "", "", "", "", "", "", "", "", "", "", "", ""], ["Positive vs. negative (reference)", "0.4220", "0.8092", "0.4827–1.3570", "0.7896", "0.9077", "0.4454–1.8470", "0.7860", "1.0570", "0.7077–1.5790", "0.4663", "1.2375", "0.6975–2.1960"], ["CIN", "", "", "", "", "", "", "", "", "", "", "", ""], ["Positive vs. negative (reference)", "0.3020", "1.3170", "0.7808–2.2220", "0.6872", "0.8826", "1.0516–4.6260", "0.1880", "0.7767", "0.5331–1.1320", "0.3441", "0.8138", "0.5310–1.2470"], ["TP53 status", "", "", "", "", "", "", "", "", "", "", "", ""], ["MUT vs. WT (reference)", "0.1570", "1.3223", "0.8984–1.9460", "0.5764", "1.1240", "0.7455–1.6930", "0.3140", "1.1960", "0.8439–1.6960", "0.4809", "1.1417", "0.7898–1.6510"], ["KRAS status", "", "", "", "", "", "", "", "", "", "", "", ""], ["MUT vs. WT (reference)", "0.0774", "1.3550", "0.9672–1.8980", "0.0245", "1.5410", "1.0567–2.2450", "0.0377", "1.3597", "1.0176–1.8170", "0.1583", "1.2646", "0.9127–1.7520"], ["BRAF status", "", "", "", "", "", "", "", "", "", "", "", ""], ["MUT Vs. 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