CXCL11 Correlates With Antitumor Immunity and an Improved Prognosis in Colon Cancer.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:33777950", "kind": "science-record", "revision": 6, "content_hash": "sha256:b071d21f98bf5e0f11a1f0f0679397337d4fa2493a25a31fc6b7798e510820e7", "created_at": "2026-11-01T15:41:30Z", "updated_at": "2026-11-01T21:25:01Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "CXCL11 Correlates With Antitumor Immunity and an Improved Prognosis in Colon Cancer.", "doi": "10.3389/fcell.2021.646252", "pmid": "33777950", "authors": ["Yingying Cao", "Nanlin Jiao", "Tiantian Sun", "Yanru Ma", "Xinyu Zhang", "Haoyan Chen", "Jie Hong", "Youwei Zhang"], "journal": "Frontiers in cell and developmental biology", "year": 2021, "abstract": "The chemokine ligand C-X-C motif chemokine ligand 11 (CXCL11) is involved in the progression of various cancers, but its biological roles in colorectal cancer (CRC) remain confused. Therefore, the prognostic value and underlying mechanism of CXCL11 in CRC were preliminarily evaluated. Three independent datasets were used for mRNA-related analysis: one dataset from the Cancer Genome Atlas (TCGA, n = 451) and two single-cell RNA sequencing (scRNA-seq) datasets from Gene Expression Omnibus (GEO): GSE146771 and GSE132465. In addition, a colon adenocarcinoma (COAD) patient cohort (the Yijishan Hospital cohort, YJSHC, n = 108) was utilized for analysis of cell infiltration by immunohistochemistry. We determined the distribution of CXCL11 in tumor tissue across all TCGA cancers and found that CXCL11 expression was significantly upregulated in both COAD and rectal adenocarcinoma (READ). However, the upregulation of CXCL11 mRNA was associated with a better prognosis in COAD, but not in READ. Within the YJSHC, the patients with a high abundance of intratumoral CXCL11+ cells had prolonged survival (p = 0.001). Furthermore, we found that the high CXCL11 expression group had a higher proportion of antitumor immune cells, and a lower proportion of protumor immune cells. Additionally, we discovered the changes of gene expression and enriched immune pathway network mediated by CXCL11. Interestingly, both cytotoxic genes (IFNG, GZMA, GZMB, GZMK, GZMM, and PRF1) and immunosuppressive molecules, including PD-L1, were positively correlated with CXCL11 expression. CXCL11, which promoted antitumor immunity to benefit survival, was identified as an independent prognostic biomarker in patients with COAD.", "claims": [{"id": "claim-method", "statement": "Additionally, multiple Cox regression analysis was used to verify that the prognostic value of intratumoral CXCL11+ cell infiltration kept significant after adjusting for confounders (HR = 0.35; 95% CI 0.17–0.72; P = 0.004; Figure 4D).", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:33777950", "locator": "sections[14] \"Differential Expression and Prognostic Value of CXCL11+ Cells in YJSHC\" paragraph 2", "quote": "Additionally, multiple Cox regression analysis was used to verify that the prognostic value of intratumoral CXCL11+ cell infiltration kept significant after adjusting for confounders (HR = 0.35; 95% CI 0.17–0.72; P = 0.004; Figure 4D)."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The datasets generated for this study can be found in the online repositories. 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