Analysis of MCM Proteins' Role as a Potential Target of Statins in Patients with Acute Type A Aortic Dissection through Bioinformatics.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:33803192", "kind": "science-record", "revision": 8, "content_hash": "sha256:17120cec9bcae5d9f8a44b9c84202a10627b26b21542ed20563bc6a2b422ddc5", "created_at": "2026-11-01T15:41:31Z", "updated_at": "2026-11-01T22:46:26Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Analysis of MCM Proteins' Role as a Potential Target of Statins in Patients with Acute Type A Aortic Dissection through Bioinformatics.", "doi": "10.3390/genes12030387", "pmid": "33803192", "authors": ["Zheyong Liang", "Yongjian Zhang", "Qiang Chen", "Junjun Hao", "Haichen Wang", "Yongxin Li", "Yang Yan"], "journal": "Genes", "year": 2021, "abstract": "Acute aortic dissection is one of the most severe vascular diseases. The molecular mechanisms of aortic expansion and dissection are unclear. Clinical studies have found that statins play a protective role in aortic dissection development and therapy; however, the mechanism of statins' effects on the aorta is unknown. The Gene Expression Omnibus (GEO) dataset GSE52093, GSE2450and GSE8686 were analyzed, and genes expressed differentially between aortic dissection samples and normal samples were determined using the Networkanalyst and iDEP tools. Weight gene correlation network analysis (WGCNA), functional annotation, pathway enrichment analysis, and the analysis of the regional variations of genomic features were then performed. We found that the minichromosome maintenance proteins (MCMs), a family of proteins targeted by statins, were upregulated in dissected aortic wall tissues and play a central role in cell-cycle and mitosis regulation in aortic dissection patients. 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Identification of DEGs and the Expression of MCM Proteins", "row_count": 8, "column_count": 3}, "table": {"label": "Table 1", "caption": "MCM expression in aortic dissections vs. normal controls.", "rows": [["Gene", "logFC", "adj-P-Val"], ["MCM2", "2.62753", "0.00817"], ["MCM3", "0.66044", "0.08468"], ["MCM4", "2.37032", "0.00656"], ["MCM5", "1.52354", "0.03502"], ["MCM6", "0.86740", "0.01988"], ["MCM7", "0.78220", "0.06388"], ["MCM10", "3.21558", "0.00684"]], "row_count": 8, "column_count": 3, "numeric_cells": 15, "header_rows": 1, "locator": "section[10]/table-wrap[1]#genes-12-00387-t001"}}, {"id": "asset:table:pmid:33803192:2", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:22edc390ef60962749663aaf332f0eb12102b0ca99af6460fbdaa8d11e257962", "bytes": 976, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[12]/table-wrap[1]#genes-12-00387-t002", "version": null, "note": "The regional variations of genomic features of aortic dissection.", "structure": {"pmcid": "PMC7998850", "section_index": 12, "section_title": "3.4. 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