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pmid:33911900
C8B in Complement and Coagulation Cascades Signaling Pathway is a predictor for Survival in HBV-Related Hepatocellular Carcinoma Patients.
Yuan Zhang · Xiaorong Chen · Yajuan Cao · Zongguo Yang
Cancer management and research · 2021 doi:10.2147/CMAR.S302917
Paper
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Experiment
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Complete file
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This study aimed to investigate the associations between enriched differentially expressed genes (DEGs) in this pathway and hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) patients.\nMATERIALS AND METHODS: Clinical and gene expression data of the Gene Expression Omnibus (GEO) series profile GSE14520 were downloaded. The \"Limma\" package was used to screen the DEGs and the \"clusterProfiler\" package was used to identify the complement and coagulation cascades pathway and enriched significant genes. Cox regression analysis, the Kaplan-Meier method, and the nomogram model were used to address the correlations between significantly enriched DEGs in the complement and coagulation cascades pathway and HCC survival.\nRESULTS: A total of 220 HBV-related HCC patients were enrolled in this study. The complement and coagulation cascades pathway was significantly enriched by 37 DEGs (p-value < 0.05 and adjusted p-value < 0.05). Complement 8 beta chain (C8B) expression levels had protective effects on overall survival (OS) and recurrence-free survival (RFS) in HBV-related HCC patients. High levels of C8B contributed to favorable OS and RFS in this population (both p < 0.01), even after adjustment of clinicopathological characteristics including tumor node metastasis (TNM) staging, Barcelona Clinic liver cancer (BCLC) staging, gender, and fibrinogen beta chain (FGB) expression (all p < 0.05).\nCONCLUSION: C8B in the complement and coagulation cascades signaling pathway serves as a predictive candidate for survival in HBV-related HCC patients.", "claims": [{"id": "claim-data-access", "statement": "Datasets of the current study are available from the NCBI Gene Expression Omnibus (https://www.ncbi.nlm.nih.gov/geo/, GSE14520). 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(%)", "80 (36.5)"], ["AFP > 300 ng/mL, n (%)", "99 (45.6)"], ["BCLC staging, n (%)", ""], ["0-A", "170 (77.3)"], ["B", "22 (10.0)"], ["C", "28 (12.7)"], ["TNM staging, n (%)", ""], ["I", "95 (43.2)"], ["II", "77 (35.0)"], ["III", "48 (21.8)"], ["CLIP staging, n (%)", ""], ["0", "100 (45.5)"], ["1", "74 (33.6)"], ["2", "33 (15.0)"], ["3–5", "13 (5.9)"]], "row_count": 24, "column_count": 2, "numeric_cells": 28, "header_rows": 1, "locator": "section[11]/table-wrap[1]#t0001"}}, {"id": "asset:table:pmid:33911900:2", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:6e05840bf91a5db0fb238123ae3f340b1f57996a89b801d1d41210d57555617e", "bytes": 4017, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[13]/table-wrap[1]#t0002", "version": null, "note": "Univariate and Multivariate Cox Regression Models for Screening Parameters Correlated with OS and RFS in HCC Patients", "structure": {"pmcid": "PMC8075182", "section_index": 13, "section_title": "Parameters Correlated with OS in HCC Patients", "row_count": 35, "column_count": 9}, "table": {"label": "Table 2", "caption": "Univariate and Multivariate Cox Regression Models for Screening Parameters Correlated with OS and RFS in HCC Patients", "rows": [["Variables#", "OS", "RFS"], ["Univariate", "Multivariate", "Univariate", "Multivariate"], ["HR (95% CI)", "p", "HR (95% CI)", "p", "HR (95% CI)", "p", "HR (95% CI)", "p"], ["Gender, male vs female", "ns", "ns", "ns", "ns", "2.15 (1.12–4.11)", "0.021", "2.05 (1.03–4.06)", "0.04"], ["Tumor size > 5 cm, yes vs no", "1.97 (1.28–3.03)", "0.002", "1.2 (0.67–2.17)", "0.541", "1.41 (0.98–2.04)", "0.066", "1.09 (0.68–1.73)", "0.723"], ["Cirrhosis, yes vs no", "4.58 (1.13–18.61)", "0.034", "4.17 (0.96–18.1)", "0.057", "2.17 (0.95–4.93)", "0.065", "1.82 (0.77–4.33)", "0.173"], ["BCLC staging", "", "", "", "", "", "", "", ""], ["0-A", "Reference", "1.0", "Reference", "1.0", "Reference", "1.0", "Reference", "1.0"], ["B", "2.40 (1.28–4.53)", "0.007", "1.03 (0.4–2.63)", "0.948", "2.08 (1.19–3.64)", "0.01", "1.83 (0.87–3.85)", "0.111"], ["C", "4.60 (2.72–7.76)", "< 0.001", "2.22 (0.75–6.6)", "0.15", "3.26 (2.02–5.25)", "< 0.001", "4.43 (1.73–11.37)", "0.002"], ["TNM staging", "", "", "", "", "", "", "", ""], ["I", "Reference", "1.0", "Reference", "1.0", "Reference", "1.0", "Reference", "1.0"], ["II", "2.08 (1.21–3.59)", "0.008", "1.83 (1.01–3.33)", "0.047", "1.97 (1.29–3.02)", "0.002", "1.59 (1.001–2.53)", "0.049"], ["III", "4.93 (2.82–8.6)", "< 0.001", "2.03 (0.74–5.57)", "0.171", "3.06 (1.91–4.9)", "< 0.001", "0.97 (0.42–2.22)", "0.941"], ["CLIP staging", "", "", "", "", "", "", "", ""], ["0", "Reference", "1.0", "Reference", "1.0", "Reference", "1.0", "Reference", "1.0"], ["1", "1.42 (0.83–2.42)", "0.198", "1.42 (0.67–3.0)", "0.357", "1.23 (0.81–1.88)", "0.333", "1.09 (0.68–1.75)", "0.711"], ["2", "2.95 (1.66–5.25)", "< 0.001", "1.42 (0.46–4.34)", "0.538", "1.94 (1.17–3.22)", "0.01", "0.88 (0.45–1.7)", "0.695"], ["3–5", "6.24 (3.01–12.93)", "< 0.001", "1.94 (0.43–8.7)", "0.385", "3.07 (1.55–6.07)", "0.001", "0.74 (0.27–2.02)", "0.558"], ["AFP > 300 ng/mL, yes vs no", "1.60 (1.04–2.45)", "0.032", "0.93 (0.41–2.09)", "0.86", "ns", "ns", "ns", "ns"], ["C8B, high vs low", "0.49 (0.32–0.77)", "0.002", "0.51 (0.29–0.92)", "0.024", "0.55 (0.38–0.79)", "0.001", "0.61 (0.4–0.96)", "0.031"], ["PLG, high vs low", "0.61 (0.39–0.94)", "0.025", "1.13 (0.64–2.0)", "0.684", "0.66 (0.46–0.94)", "0.023", "1.01 (0.61–1.69)", "0.958"], ["SERPINC1, high vs low", "0.48 (0.31–0.75)", "0.001", "0.99 (0.5–1.94)", "0.968", "0.59 (0.41–0.84)", "0.004", "0.9 (0.51–1.59)", "0.724"], ["MASP2, high vs low", "0.49 (0.31–0.76)", "0.001", "0.88 (0.47–1.64)", "0.687", "0.63 (0.44–0.9)", "0.011", "0.99 (0.59–1.67)", "0.983"], ["CPB2, high vs low", "0.55 (0.35–0.85)", "0.007", "0.8 (0.46–1.4)", "0.443", "0.68 (0.48–0.98)", "0.038", "0.99 (0.62–1.57)", "0.96"], ["KLKB1, high vs low", "0.5 (0.32–0.78)", "0.002", "0.68 (0.36–1.3)", "0.243", "0.72 (0.5–1.03)", "0.074", "1.04 (0.63–1.71)", "0.883"], ["F12, high vs low", "0.44 (0.28–0.68)", "< 0.001", "0.72 (0.4–1.28)", "0.26", "0.55 (0.39–0.8)", "0.001", "0.97 (0.61–1.56)", "0.915"], ["CFB, high vs low", "0.64 (0.41–0.98)", "0.04", "1.12 (0.64–1.97)", "0.698", "ns", "ns", "ns", "ns"], ["KNG1, high vs low", "0.53 (0.34–0.83)", "0.005", "0.97 (0.55–1.73)", "0.925", "0.58 (0.4–0.83)", "0.003", "0.72 (0.45–1.14)", "0.159"], ["SERPING1, high vs low", "0.63 (0.41–0.98)", "0.038", "1.52 (0.83–2.76)", "0.173", "ns", "ns", "ns", "ns"], ["VTN, high vs low", "0.62 (0.40–0.96)", "0.032", "0.85 (0.5–1.47)", "0.568", "0.7 (0.49–1.01)", "0.055", "1.05 (0.65–1.69)", "0.836"], ["F2, high vs low", "0.63 (0.41–0.98)", "0.04", "1.27 (0.74–2.19)", "0.384", "ns", "ns", "ns", "ns"], ["F11, high vs low", "0.57 (0.37–0.88)", "0.011", "1.06 (0.57–1.96)", "0.865", "0.7 (0.49–1.01)", "0.056", "1.0 (0.63–1.57)", "0.98"], ["FGB, high vs low", "ns", "ns", "ns", "ns", "1.54 (1.07–2.22)", "0.02", "1.98 (1.32–2.97)", "0.001"], ["SERPINA5, high vs low", "ns", "ns", "ns", "Ns", "0.66 (0.46–0.94)", "0.022", "0.99 (0.63–1.57)", "0.98"]], "row_count": 35, "column_count": 9, "numeric_cells": 205, "header_rows": 3, "locator": "section[13]/table-wrap[1]#t0002"}}], "gaps": ["asset:data:geo:GSE14520 not downloaded", "asset:data:geo:GSE14520 licence not read"]}, "analysis": {"state": "complete", "methods": [{"id": "method-1", "family": "survival_analysis", "specific": "cox_proportional_hazards", "label": "Survival analysis", "dsl_operations": ["cox_ph"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["time_to_event_with_censoring"], "evidence": {"score": 1.0, "band": "reordered", "quote": "“Parameters associated with the outcomes were assessed by univariate analysis and multivariate analysis using Cox regression.”"}}, {"id": "method-2", "family": "survival_analysis", 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The physical bench the paper used is not, so a physical validation cannot be run here."}, "data": {"tier": "R1", "reachable": true, "accessions": ["GSE14520"], "resolved_accessions": ["GSE14520"], "statements": ["Datasets of the current study are available from the NCBI Gene Expression Omnibus (https://www.ncbi.nlm.nih.gov/geo/, GSE14520). All the datasets are available from the corresponding author (Z.Y) in response to a reasonable request."], "basis": "The paper names GSE14520 in Gene Expression Omnibus (GEO) and the accession resolves in the repository. 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