← All .science files
pmid:34026630
Prognostic Value and Related Regulatory Networks of MRPL15 in Non-Small-Cell Lung Cancer.
Yangyang Zeng · Yingying Shi · Lu Xu · Yulan Zeng · Xiao Cui · Yuan Wang · Ningning Yang · Fuxiang Zhou · Yunfeng Zhou
Frontiers in oncology · 2021 doi:10.3389/fonc.2021.656172
Paper
complete
Experiment
complete
Data
partial
Analysis
complete
Execution
absent
Execution evidence has not yet been added to this .science file. Explore its methods, data and open questions to plan the next step.
Record details sci_version · id · kind · revision · content_hash · schema · created_at · updated_at · generator
paper object · 10 fields
authors array · 9 items
claims array · 1 item
gaps array · 0 items
experiment object · 8 fields
steps array · 3 items
[0] object · 13 fields
parameters object · 0 fields
inputs array · 1 item
outputs array · 1 item
instruments array · 0 items
reagents array · 0 items
[1] object · 13 fields
parameters object · 0 fields
inputs array · 1 item
outputs array · 1 item
instruments array · 0 items
reagents array · 0 items
[2] object · 13 fields
parameters object · 0 fields
inputs array · 1 item
outputs array · 1 item
instruments array · 0 items
reagents array · 0 items
materials array · 0 items
instruments array · 0 items
reagents array · 0 items
conditions object · 0 fields
gaps array · 0 items
data object · 3 fields
assets array · 16 items
[0] object · 15 fields
structure object · 4 fields
[1] object · 15 fields
structure object · 15 fields
sample_accessions array · 66 items
[2] object · 15 fields
structure object · 15 fields
sample_accessions array · 117 items
[3] object · 15 fields
structure object · 15 fields
sample_accessions array · 91 items
[4] object · 15 fields
structure object · 15 fields
sample_accessions array · 156 items
[5] object · 15 fields
structure object · 15 fields
sample_accessions array · 120 items
[6] object · 15 fields
structure object · 15 fields
sample_accessions array · 42 items
[7] object · 15 fields
structure object · 15 fields
sample_accessions array · 50 items
[8] object · 15 fields
structure object · 15 fields
sample_accessions array · 246 items
[9] object · 15 fields
structure object · 15 fields
sample_accessions array · 100 items
[10] object · 15 fields
structure object · 15 fields
sample_accessions array · 75 items
[11] object · 15 fields
structure object · 15 fields
sample_accessions array · 138 items
[12] object · 16 fields
structure object · 5 fields
table object · 8 fields
rows array · 9 items
[0] array · 5 items
[1] array · 5 items
[2] array · 5 items
[3] array · 5 items
[4] array · 5 items
[5] array · 5 items
[6] array · 5 items
[7] array · 5 items
[8] array · 5 items
[13] object · 16 fields
structure object · 5 fields
table object · 8 fields
rows array · 20 items
[0] array · 3 items
[1] array · 7 items
[2] array · 7 items
[3] array · 7 items
[4] array · 7 items
[5] array · 7 items
[6] array · 7 items
[7] array · 7 items
[8] array · 7 items
[9] array · 7 items
[10] array · 7 items
[11] array · 7 items
[12] array · 7 items
[13] array · 7 items
[14] array · 7 items
[15] array · 7 items
[16] array · 7 items
[17] array · 7 items
[18] array · 7 items
[19] array · 7 items
[14] object · 16 fields
structure object · 5 fields
table object · 8 fields
rows array · 25 items
[0] array · 5 items
[1] array · 4 items
[2] array · 4 items
[3] array · 6 items
[4] array · 6 items
[5] array · 4 items
[6] array · 6 items
[7] array · 6 items
[8] array · 4 items
[9] array · 6 items
[10] array · 6 items
[11] array · 4 items
[12] array · 4 items
[13] array · 6 items
[14] array · 6 items
[15] array · 4 items
[16] array · 6 items
[17] array · 6 items
[18] array · 4 items
[19] array · 6 items
[20] array · 6 items
[21] array · 4 items
[22] array · 6 items
[23] array · 6 items
[24] array · 4 items
[15] object · 16 fields
structure object · 5 fields
table object · 8 fields
rows array · 18 items
[0] array · 3 items
[1] array · 6 items
[2] array · 7 items
[3] array · 7 items
[4] array · 7 items
[5] array · 7 items
[6] array · 7 items
[7] array · 7 items
[8] array · 7 items
[9] array · 7 items
[10] array · 7 items
[11] array · 7 items
[12] array · 7 items
[13] array · 7 items
[14] array · 7 items
[15] array · 7 items
[16] array · 7 items
[17] array · 7 items
gaps array · 22 items
analysis object · 4 fields
methods array · 5 items
[0] object · 10 fields
dsl_operations array · 1 item
missing_operations array · 0 items
parameters object · 0 fields
data_shapes array · 1 item
[1] object · 10 fields
dsl_operations array · 1 item
missing_operations array · 0 items
parameters object · 0 fields
data_shapes array · 1 item
[2] object · 10 fields
dsl_operations array · 1 item
missing_operations array · 0 items
parameters object · 0 fields
data_shapes array · 1 item
[3] object · 10 fields
dsl_operations array · 3 items
missing_operations array · 0 items
parameters object · 0 fields
data_shapes array · 1 item
[4] object · 10 fields
dsl_operations array · 1 item
missing_operations array · 0 items
parameters object · 0 fields
data_shapes array · 1 item
targets array · 0 items
gaps array · 0 items
capability object · 3 fields
requirements array · 1 item
[0] object · 6 fields
assay_families array · 9 items
gaps array · 0 items
readiness object · 8 fields
axes object · 3 fields
method object · 5 fields
required_operations array · 1 item
missing_operations array · 0 items
capability object · 4 fields
data object · 6 fields
accessions array · 11 items
resolved_accessions array · 11 items
statements array · 1 item
can_run object · 3 fields
dsl_operations array · 1 item
assets array · 6 items
steps array · 1 item
must_build object · 5 fields
dsl_operations array · 0 items
converters array · 0 items
readers array · 0 items
capabilities array · 0 items
data_gaps array · 1 item
gaps array · 0 items
review object · 5 fields
machine_critique object · 5 fields
reader object · 5 fields
evidence_check object · 2 fields
usage object · 3 fields
stages array · 1 item
[0] object · 4 fields
gaps array · 3 items
provenance object · 7 fields
entities array · 3 items
activities array · 3 items
[0] object · 4 fields
used array · 3 items
[0] object · 3 fields
[1] object · 3 fields
[2] object · 3 fields
[1] object · 4 fields
agents array · 2 items
lineage object · 4 fields
gaps array · 26 items
assays array · 2 items
[0] object · 11 fields
required_operations array · 0 items
source_hashes object · 1 field
evidence array · 4 items
[1] object · 11 fields
required_operations array · 1 item
source_hashes object · 1 field
evidence array · 1 item
Complete file
{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:34026630", "kind": "science-record", "revision": 7, "content_hash": "sha256:ad97a4a5eb3a32b2818ec1ad7dae44b672f48bc2e0d04dec9ab761fcabc6e98a", "created_at": "2026-11-01T15:41:36Z", "updated_at": "2026-11-01T22:03:49Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Prognostic Value and Related Regulatory Networks of MRPL15 in Non-Small-Cell Lung Cancer.", "doi": "10.3389/fonc.2021.656172", "pmid": "34026630", "authors": ["Yangyang Zeng", "Yingying Shi", "Lu Xu", "Yulan Zeng", "Xiao Cui", "Yuan Wang", "Ningning Yang", "Fuxiang Zhou", "Yunfeng Zhou"], "journal": "Frontiers in oncology", "year": 2021, "abstract": "BACKGROUND: Mitochondrial ribosomal protein L15 (MRPL15), a member of mitochondrial ribosomal proteins whose abnormal expression is related to tumorigenesis. However, the prognostic value and regulatory mechanisms of MRPL15 in non-small-cell lung cancer (NSCLC) remain unclear.\nMETHODS: GEPIA, ONCOMINE, Gene Expression Omnibus (GEO), UALCAN, Kaplan-Meier plotter, PrognoScan, LinkedOmics and GeneMANIA database were utilized to explore the expression and prognostic value of MRPL15 in NSCLC. Additionally, immune infiltration patterns were evaluated via ESTIMATE algorithm and TISIDB database. Furthermore, the expression and prognostic value of MRPL15 in lung cancer were validated via immunohistochemistry (IHC) assays.\nRESULTS: In NSCLC, multiple cohorts including GEPIA, ONCOMINE and 8 GEO series (GSE8569, GSE101929, GSE33532, GSE27262, GSE21933, GSE19804, GSE19188, GSE18842) described that MRPL15 was up-regulated. Moreover, MRPL15 was notably linked to gender, clinical stage, lymph node status and the TP53 mutation status. And patients with high MRPL15 expression showed poor overall survival (OS), progression-free survival (PFS), disease-free survival (DFS) and relapse-free survival (RFS) in NSCLC. Then, functional network analysis suggested that MRPL15 participated in metabolism-related pathways, DNA replication and cell cycle signaling via pathways involving several kinases, miRNAs and transcription factors. Additionally, it was found that MRPL15 expression was negatively related to immune infiltration, including immune scores, stromal scores and several tumor-infiltrating lymphocytes (TILs). Furthermore, IHC results further confirmed the high MRPL15 expression and its prognostic potential in lung cancer.\nCONCLUSIONS: These findings demonstrate that high MRPL15 expression indicates poor prognosis in NSCLC and reveal potential regulatory networks as well as the negative relationship with immune infiltration. Thus, MRPL15 may be an attractive predictor and therapeutic strategy for NSCLC.", "claims": [{"id": "claim-data-access", "statement": "The original contributions presented in the study are included in the article/ Supplementary Material . Further inquiries can be directed to the corresponding authors.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:34026630", "locator": "sections[22] \"Data Availability Statement\" paragraph 2", "quote": "The original contributions presented in the study are included in the article/ Supplementary Material . Further inquiries can be directed to the corresponding authors."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": null, "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:34026630"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. This lane did not download the dataset or read its licence.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE101929"], "outputs": ["the source data with its repository provenance"], "instruments": [], "reagents": []}, {"id": "run_analysis", "order": 3, "name": "Run the published analysis", "kind": "analysis", "state": "complete", "blocked_on": null, "description": "Apply the paper's statistical method to the resolved series and compare the result with the published target.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE101929"], "outputs": ["the replicated result and its comparison"], "instruments": [], "reagents": []}], "materials": [], "instruments": [], "reagents": [], "conditions": {}, "gaps": []}, "data": {"state": "partial", "assets": [{"id": "source:pmid:34026630", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.3389/fonc.2021.656172", "sha256": "sha256:d03c7ed82f4ad668712424c2d7e56e276f7ceb2c8bed027924ec946aa1460594", "bytes": 31436, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "10.3389/fonc.2021.656172", "version": null, "note": "Full article fetched from PMC; the checksum covers the rendered section body, not the original XML bytes.", "structure": {"pmcid": "PMC8138120", "source": "europe_pmc_fulltext", "coverage": "whole_body_without_references", "text_hash_scope": "rendered_section_body"}}, {"id": "data:geo:GSE101929", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE101929", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE101929", "version": null, "note": "The original contributions presented in the study are included in the article/ Supplementary Material . Further inquiries can be directed to the corresponding authors.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The original contributions presented in the study are included in the article/ Supplementary Material . Further inquiries can be directed to the corresponding authors.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM2718949", "GSM2718950", "GSM2718951", "GSM2718952", "GSM2718953", "GSM2718954", "GSM2718955", "GSM2718956", "GSM2718957", "GSM2718958", "GSM2718959", "GSM2718960", "GSM2718961", "GSM2718962", "GSM2718963", "GSM2718964", "GSM2718965", "GSM2718966", "GSM2718967", "GSM2718968", "GSM2718969", "GSM2718970", "GSM2718971", "GSM2718972", "GSM2718973", "GSM2718974", "GSM2718975", "GSM2718976", "GSM2718977", "GSM2718978", "GSM2718979", "GSM2718980", "GSM2718981", "GSM2718982", "GSM2718983", "GSM2718984", "GSM2718985", "GSM2718986", "GSM2718987", "GSM2718988", "GSM2718989", "GSM2718990", "GSM2718991", "GSM2718992", "GSM2718993", "GSM2718994", "GSM2718995", "GSM2718996", "GSM2718997", "GSM2718998", "GSM2718999", "GSM2719000", "GSM2719001", "GSM2719002", "GSM2719003", "GSM2719004", "GSM2719005", "GSM2719006", "GSM2719007", "GSM2719008", "GSM2719009", "GSM2719010", "GSM2719011", "GSM2719012", "GSM2719013", "GSM2719014"], "sample_count": 66, "group_sizes": null, "group_sizes_basis": null, "platform": "570", "taxon": "Homo sapiens", "title": "Gene expression data from African Americans and European Americans with non-small cell lung cancer", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE13213", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE13213", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE13213", "version": null, "note": "The original contributions presented in the study are included in the article/ Supplementary Material . Further inquiries can be directed to the corresponding authors.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The original contributions presented in the study are included in the article/ Supplementary Material . Further inquiries can be directed to the corresponding authors.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM333673", "GSM333674", "GSM333675", "GSM333676", "GSM333677", "GSM333678", "GSM333679", "GSM333680", "GSM333681", "GSM333682", "GSM333683", "GSM333684", "GSM333685", "GSM333686", "GSM333687", "GSM333688", "GSM333689", "GSM333690", "GSM333691", "GSM333692", "GSM333693", "GSM333694", "GSM333695", "GSM333696", "GSM333697", "GSM333698", "GSM333699", "GSM333700", "GSM333701", "GSM333702", "GSM333703", "GSM333704", "GSM333705", "GSM333706", "GSM333707", "GSM333708", "GSM333709", "GSM333710", "GSM333711", "GSM333712", "GSM333713", "GSM333714", "GSM333715", "GSM333716", "GSM333717", "GSM333718", "GSM333719", "GSM333720", "GSM333721", "GSM333722", "GSM333723", "GSM333724", "GSM333725", "GSM333726", "GSM333727", "GSM333728", "GSM333729", "GSM333730", "GSM333731", "GSM333732", "GSM333733", "GSM333734", "GSM333735", "GSM333736", "GSM333737", "GSM333738", "GSM333739", "GSM333740", "GSM333741", "GSM333742", "GSM333743", "GSM333744", "GSM333745", "GSM333746", "GSM333747", "GSM333748", "GSM333749", "GSM333750", "GSM333751", "GSM333752", "GSM333753", "GSM333754", "GSM333755", "GSM333756", "GSM333757", "GSM333758", "GSM333759", "GSM333760", "GSM333761", "GSM333762", "GSM333763", "GSM333764", "GSM333765", "GSM333766", "GSM333767", "GSM333768", "GSM333769", "GSM333770", "GSM333771", "GSM333772", "GSM333773", "GSM333774", "GSM333775", "GSM333776", "GSM333777", "GSM333778", "GSM333779", "GSM333780", "GSM333781", "GSM333782", "GSM333783", "GSM333784", "GSM333785", "GSM333786", "GSM333787", "GSM333788", "GSM333789"], "sample_count": 117, "group_sizes": null, "group_sizes_basis": null, "platform": "6480", "taxon": "Homo sapiens", "title": "Relapse-related molecular signature in lung adenocarcinomas identifies patients with dismal prognosis", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE18842", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE18842", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE18842", "version": null, "note": "The original contributions presented in the study are included in the article/ Supplementary Material . Further inquiries can be directed to the corresponding authors.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The original contributions presented in the study are included in the article/ Supplementary Material . Further inquiries can be directed to the corresponding authors.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM466947", "GSM466948", "GSM466949", "GSM466950", "GSM466951", "GSM466952", "GSM466953", "GSM466954", "GSM466955", "GSM466956", "GSM466957", "GSM466958", "GSM466959", "GSM466960", "GSM466961", "GSM466962", "GSM466963", "GSM466964", "GSM466965", "GSM466966", "GSM466967", "GSM466968", "GSM466969", "GSM466970", "GSM466971", "GSM466972", "GSM466973", "GSM466974", "GSM466975", "GSM466976", "GSM466977", "GSM466978", "GSM466979", "GSM466980", "GSM466981", "GSM466982", "GSM466983", "GSM466984", "GSM466985", "GSM466986", "GSM466987", "GSM466988", "GSM466989", "GSM466990", "GSM466991", "GSM466992", "GSM466993", "GSM466994", "GSM466995", "GSM466996", "GSM466997", "GSM466998", "GSM466999", "GSM467000", "GSM467001", "GSM467002", "GSM467003", "GSM467004", "GSM467005", "GSM467006", "GSM467007", "GSM467008", "GSM467009", "GSM467010", "GSM467011", "GSM467012", "GSM467013", "GSM467014", "GSM467015", "GSM467016", "GSM467017", "GSM467018", "GSM467019", "GSM467020", "GSM467021", "GSM467022", "GSM467023", "GSM467024", "GSM467025", "GSM467026", "GSM467027", "GSM467028", "GSM467029", "GSM467030", "GSM467031", "GSM467032", "GSM467033", "GSM467034", "GSM467035", "GSM467036", "GSM467037"], "sample_count": 91, "group_sizes": null, "group_sizes_basis": null, "platform": "570", "taxon": "Homo sapiens", "title": "Gene expression analysis of human lung cancer and control samples", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE19188", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE19188", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE19188", "version": null, "note": "The original contributions presented in the study are included in the article/ Supplementary Material . Further inquiries can be directed to the corresponding authors.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The original contributions presented in the study are included in the article/ Supplementary Material . Further inquiries can be directed to the corresponding authors.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM475656", "GSM475657", "GSM475658", "GSM475659", "GSM475660", "GSM475661", "GSM475662", "GSM475663", "GSM475664", "GSM475665", "GSM475666", "GSM475667", "GSM475668", "GSM475669", "GSM475670", "GSM475671", "GSM475672", "GSM475673", "GSM475674", "GSM475675", "GSM475676", "GSM475677", "GSM475678", "GSM475679", "GSM475680", "GSM475681", "GSM475682", "GSM475683", "GSM475684", "GSM475685", "GSM475686", "GSM475687", "GSM475688", "GSM475689", "GSM475690", "GSM475691", "GSM475692", "GSM475693", "GSM475694", "GSM475695", "GSM475696", "GSM475697", "GSM475698", "GSM475699", "GSM475700", "GSM475701", "GSM475702", "GSM475703", "GSM475704", "GSM475705", "GSM475706", "GSM475707", "GSM475708", "GSM475709", "GSM475710", "GSM475711", "GSM475712", "GSM475713", "GSM475714", "GSM475715", "GSM475716", "GSM475717", "GSM475718", "GSM475719", "GSM475720", "GSM475721", "GSM475722", "GSM475723", "GSM475724", "GSM475725", "GSM475726", "GSM475727", "GSM475728", "GSM475729", "GSM475730", "GSM475731", "GSM475732", "GSM475733", "GSM475734", "GSM475735", "GSM475736", "GSM475737", "GSM475738", "GSM475739", "GSM475740", "GSM475741", "GSM475742", "GSM475743", "GSM475744", "GSM475745", "GSM475746", "GSM475747", "GSM475748", "GSM475749", "GSM475750", "GSM475751", "GSM475752", "GSM475753", "GSM475754", "GSM475755", "GSM475756", "GSM475757", "GSM475758", "GSM475759", "GSM475760", "GSM475761", "GSM475762", "GSM475763", "GSM475764", "GSM475765", "GSM475766", "GSM475767", "GSM475768", "GSM475769", "GSM475770", "GSM475771", "GSM475772", "GSM475773", "GSM475774", "GSM475775", "GSM475776", "GSM475777", "GSM475778", "GSM475779", "GSM475780", "GSM475781", "GSM475782", "GSM475783", "GSM475784", "GSM475785", "GSM475786", "GSM475787", "GSM475788", "GSM475789", "GSM475790", "GSM475791", "GSM475792", "GSM475793", "GSM475794", "GSM475795", "GSM475796", "GSM475797", "GSM475798", "GSM475799", "GSM475800", "GSM475801", "GSM475802", "GSM475803", "GSM475804", "GSM475805", "GSM475806", "GSM475807", "GSM475808", "GSM475809", "GSM475810", "GSM475811"], "sample_count": 156, "group_sizes": null, "group_sizes_basis": null, "platform": "570", "taxon": "Homo sapiens", "title": "Expression data for early stage NSCLC", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE19804", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE19804", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE19804", "version": null, "note": "The original contributions presented in the study are included in the article/ Supplementary Material . Further inquiries can be directed to the corresponding authors.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The original contributions presented in the study are included in the article/ Supplementary Material . Further inquiries can be directed to the corresponding authors.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM494556", "GSM494557", "GSM494558", "GSM494559", "GSM494560", "GSM494561", "GSM494562", "GSM494563", "GSM494564", "GSM494565", "GSM494566", "GSM494567", "GSM494568", "GSM494569", "GSM494570", "GSM494571", "GSM494572", "GSM494573", "GSM494574", "GSM494575", "GSM494576", "GSM494577", "GSM494578", "GSM494579", "GSM494580", "GSM494581", "GSM494582", "GSM494583", "GSM494584", "GSM494585", "GSM494586", "GSM494587", "GSM494588", "GSM494589", "GSM494590", "GSM494591", "GSM494592", "GSM494593", "GSM494594", "GSM494595", "GSM494596", "GSM494597", "GSM494598", "GSM494599", "GSM494600", "GSM494601", "GSM494602", "GSM494603", "GSM494604", "GSM494605", "GSM494606", "GSM494607", "GSM494608", "GSM494609", "GSM494610", "GSM494611", "GSM494612", "GSM494613", "GSM494614", "GSM494615", "GSM494616", "GSM494617", "GSM494618", "GSM494619", "GSM494620", "GSM494621", "GSM494622", "GSM494623", "GSM494624", "GSM494625", "GSM494626", "GSM494627", "GSM494628", "GSM494629", "GSM494630", "GSM494631", "GSM494632", "GSM494633", "GSM494634", "GSM494635", "GSM494636", "GSM494637", "GSM494638", "GSM494639", "GSM494640", "GSM494641", "GSM494642", "GSM494643", "GSM494644", "GSM494645", "GSM494646", "GSM494647", "GSM494648", "GSM494649", "GSM494650", "GSM494651", "GSM494652", "GSM494653", "GSM494654", "GSM494655", "GSM494656", "GSM494657", "GSM494658", "GSM494659", "GSM494660", "GSM494661", "GSM494662", "GSM494663", "GSM494664", "GSM494665", "GSM494666", "GSM494667", "GSM494668", "GSM494669", "GSM494670", "GSM494671", "GSM494672", "GSM494673", "GSM494674", "GSM494675"], "sample_count": 120, "group_sizes": null, "group_sizes_basis": null, "platform": "570", "taxon": "Homo sapiens", "title": "Genome-wide screening of transcriptional modulation in non-smoking female lung cancer in Taiwan", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE21933", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE21933", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE21933", "version": null, "note": "The original contributions presented in the study are included in the article/ Supplementary Material . Further inquiries can be directed to the corresponding authors.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The original contributions presented in the study are included in the article/ Supplementary Material . Further inquiries can be directed to the corresponding authors.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM545615", "GSM545616", "GSM545617", "GSM545618", "GSM545619", "GSM545620", "GSM545621", "GSM545622", "GSM545623", "GSM545624", "GSM545625", "GSM545626", "GSM545627", "GSM545628", "GSM545629", "GSM545630", "GSM545631", "GSM545632", "GSM545633", "GSM545634", "GSM545635", "GSM545636", "GSM545637", "GSM545638", "GSM545639", "GSM545640", "GSM545641", "GSM545642", "GSM545643", "GSM545644", "GSM545645", "GSM545646", "GSM545647", "GSM545648", "GSM545649", "GSM545650", "GSM545651", "GSM545652", "GSM545653", "GSM545654", "GSM545655", "GSM545656"], "sample_count": 42, "group_sizes": null, "group_sizes_basis": null, "platform": "6254", "taxon": "Homo sapiens", "title": "Gene expression profiles of tumor and paired normal lung tissues from primary non-small cell lung cancer (NSCLC) patients in Taiwan.", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE27262", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE27262", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE27262", "version": null, "note": "The original contributions presented in the study are included in the article/ Supplementary Material . Further inquiries can be directed to the corresponding authors.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The original contributions presented in the study are included in the article/ Supplementary Material . Further inquiries can be directed to the corresponding authors.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM673870", "GSM673871", "GSM673872", "GSM673873", "GSM673874", "GSM673875", "GSM673876", "GSM673877", "GSM673878", "GSM673879", "GSM673880", "GSM673881", "GSM673882", "GSM673883", "GSM673884", "GSM673885", "GSM673886", "GSM673887", "GSM673888", "GSM673889", "GSM673890", "GSM673891", "GSM673892", "GSM673893", "GSM673894", "GSM673895", "GSM673896", "GSM673897", "GSM673898", "GSM673899", "GSM673900", "GSM673901", "GSM673902", "GSM673903", "GSM673904", "GSM673905", "GSM673906", "GSM673907", "GSM673908", "GSM673909", "GSM673910", "GSM673911", "GSM673912", "GSM673913", "GSM673914", "GSM673915", "GSM673916", "GSM673917", "GSM673918", "GSM673919"], "sample_count": 50, "group_sizes": null, "group_sizes_basis": null, "platform": "570", "taxon": "Homo sapiens", "title": "Gene expression profiling of Non-small cell lung cancer in Taiwan", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE31210", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE31210", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE31210", "version": null, "note": "The original contributions presented in the study are included in the article/ Supplementary Material . Further inquiries can be directed to the corresponding authors.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The original contributions presented in the study are included in the article/ Supplementary Material . Further inquiries can be directed to the corresponding authors.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM773540", "GSM773541", "GSM773542", "GSM773543", "GSM773544", "GSM773545", "GSM773546", "GSM773547", "GSM773548", "GSM773549", "GSM773550", "GSM773551", "GSM773552", "GSM773553", "GSM773554", "GSM773555", "GSM773556", "GSM773557", "GSM773558", "GSM773559", "GSM773560", "GSM773561", "GSM773562", "GSM773563", "GSM773564", "GSM773565", "GSM773566", "GSM773567", "GSM773568", "GSM773569", "GSM773570", "GSM773571", "GSM773572", "GSM773573", "GSM773574", "GSM773575", "GSM773576", "GSM773577", "GSM773578", "GSM773579", "GSM773580", "GSM773581", "GSM773582", "GSM773583", "GSM773584", "GSM773585", "GSM773586", "GSM773587", "GSM773588", "GSM773589", "GSM773590", "GSM773591", "GSM773592", "GSM773593", "GSM773594", "GSM773595", "GSM773596", "GSM773597", "GSM773598", "GSM773599", "GSM773600", "GSM773601", "GSM773602", "GSM773603", "GSM773604", "GSM773605", "GSM773606", "GSM773607", "GSM773608", "GSM773609", "GSM773610", "GSM773611", "GSM773612", "GSM773613", "GSM773614", "GSM773615", "GSM773616", "GSM773617", "GSM773618", "GSM773619", "GSM773620", "GSM773621", "GSM773622", "GSM773623", "GSM773624", "GSM773625", "GSM773626", "GSM773627", "GSM773628", "GSM773629", "GSM773630", "GSM773631", "GSM773632", "GSM773633", "GSM773634", "GSM773635", "GSM773636", "GSM773637", "GSM773638", "GSM773639", "GSM773640", "GSM773641", "GSM773642", "GSM773643", "GSM773644", "GSM773645", "GSM773646", "GSM773647", "GSM773648", "GSM773649", "GSM773650", "GSM773651", "GSM773652", "GSM773653", "GSM773654", "GSM773655", "GSM773656", "GSM773657", "GSM773658", "GSM773659", "GSM773660", "GSM773661", "GSM773662", "GSM773663", "GSM773664", "GSM773665", "GSM773666", "GSM773667", "GSM773668", "GSM773669", "GSM773670", "GSM773671", "GSM773672", "GSM773673", "GSM773674", "GSM773675", "GSM773676", "GSM773677", "GSM773678", "GSM773679", "GSM773680", "GSM773681", "GSM773682", "GSM773683", "GSM773684", "GSM773685", "GSM773686", "GSM773687", "GSM773688", "GSM773689", "GSM773690", "GSM773691", "GSM773692", "GSM773693", "GSM773694", "GSM773695", "GSM773696", "GSM773697", "GSM773698", "GSM773699", "GSM773700", "GSM773701", "GSM773702", "GSM773703", "GSM773704", "GSM773705", "GSM773706", "GSM773707", "GSM773708", "GSM773709", "GSM773710", "GSM773711", "GSM773712", "GSM773713", "GSM773714", "GSM773715", "GSM773716", "GSM773717", "GSM773718", "GSM773719", "GSM773720", "GSM773721", "GSM773722", "GSM773723", "GSM773724", "GSM773725", "GSM773726", "GSM773727", "GSM773728", "GSM773729", "GSM773730", "GSM773731", "GSM773732", "GSM773733", "GSM773734", "GSM773735", "GSM773736", "GSM773737", "GSM773738", "GSM773739", "GSM773740", "GSM773741", "GSM773742", "GSM773743", "GSM773744", "GSM773745", "GSM773746", "GSM773747", "GSM773748", "GSM773749", "GSM773750", "GSM773751", "GSM773752", "GSM773753", "GSM773754", "GSM773755", "GSM773756", "GSM773757", "GSM773758", "GSM773759", "GSM773760", "GSM773761", "GSM773762", "GSM773763", "GSM773764", "GSM773765", "GSM773766", "GSM773767", "GSM773768", "GSM773769", "GSM773770", "GSM773771", "GSM773772", "GSM773773", "GSM773774", "GSM773775", "GSM773776", "GSM773777", "GSM773778", "GSM773779", "GSM773780", "GSM773781", "GSM773782", "GSM773783", "GSM773784", "GSM773785"], "sample_count": 246, "group_sizes": null, "group_sizes_basis": null, "platform": "570", "taxon": "Homo sapiens", "title": "Gene expression data for pathological stage I-II lung adenocarcinomas", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE33532", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE33532", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE33532", "version": null, "note": "The original contributions presented in the study are included in the article/ Supplementary Material . Further inquiries can be directed to the corresponding authors.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The original contributions presented in the study are included in the article/ Supplementary Material . Further inquiries can be directed to the corresponding authors.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM835268", "GSM835269", "GSM835270", "GSM835271", "GSM835272", "GSM835273", "GSM835274", "GSM835275", "GSM835276", "GSM835277", "GSM835278", "GSM835279", "GSM835280", "GSM835281", "GSM835282", "GSM835283", "GSM835284", "GSM835285", "GSM835286", "GSM835287", "GSM835288", "GSM835289", "GSM835290", "GSM835291", "GSM835292", "GSM835293", "GSM835294", "GSM835295", "GSM835296", "GSM835297", "GSM835298", "GSM835299", "GSM835300", "GSM835301", "GSM835302", "GSM835303", "GSM835304", "GSM835305", "GSM835306", "GSM835307", "GSM835308", "GSM835309", "GSM835310", "GSM835311", "GSM835312", "GSM835313", "GSM835314", "GSM835315", "GSM835316", "GSM835317", "GSM835318", "GSM835319", "GSM835320", "GSM835321", "GSM835322", "GSM835323", "GSM835324", "GSM835325", "GSM835326", "GSM835327", "GSM835328", "GSM835329", "GSM835330", "GSM835331", "GSM835332", "GSM835333", "GSM835334", "GSM835335", "GSM835336", "GSM835337", "GSM835338", "GSM835339", "GSM835340", "GSM835341", "GSM835342", "GSM835343", "GSM835344", "GSM835345", "GSM835346", "GSM835347", "GSM835348", "GSM835349", "GSM835350", "GSM835351", "GSM835352", "GSM835353", "GSM835354", "GSM835355", "GSM835356", "GSM835357", "GSM835358", "GSM835359", "GSM835360", "GSM835361", "GSM835362", "GSM835363", "GSM835364", "GSM835365", "GSM835366", "GSM835367"], "sample_count": 100, "group_sizes": null, "group_sizes_basis": null, "platform": "570", "taxon": "Homo sapiens", "title": "Intratumor heterogeneity of gene expression profiles in early stage non-small cell lung cancer (NSCLC)", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE8569", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE8569", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE8569", "version": null, "note": "The original contributions presented in the study are included in the article/ Supplementary Material . Further inquiries can be directed to the corresponding authors.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The original contributions presented in the study are included in the article/ Supplementary Material . Further inquiries can be directed to the corresponding authors.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM212693", "GSM212694", "GSM212695", "GSM212696", "GSM212697", "GSM212698", "GSM212699", "GSM212700", "GSM212701", "GSM212702", "GSM212703", "GSM212704", "GSM212705", "GSM212706", "GSM212707", "GSM212708", "GSM212709", "GSM212710", "GSM212711", "GSM212712", "GSM212713", "GSM212714", "GSM212715", "GSM212716", "GSM212717", "GSM212718", "GSM212719", "GSM212720", "GSM212721", "GSM212722", "GSM212723", "GSM212724", "GSM212725", "GSM212726", "GSM212727", "GSM212728", "GSM212729", "GSM212730", "GSM212731", "GSM212732", "GSM212733", "GSM212734", "GSM212735", "GSM212736", "GSM212737", "GSM212738", "GSM212739", "GSM212740", "GSM212741", "GSM212742", "GSM212743", "GSM212744", "GSM212745", "GSM212746", "GSM212747", "GSM212748", "GSM212749", "GSM212750", "GSM212751", "GSM212752", "GSM212753", "GSM212754", "GSM212755", "GSM212756", "GSM212757", "GSM212758", "GSM212759", "GSM212760", "GSM212761", "GSM212762", "GSM212763", "GSM212764", "GSM212765", "GSM212766", "GSM212767"], "sample_count": 75, "group_sizes": null, "group_sizes_basis": null, "platform": "5645", "taxon": "Homo sapiens", "title": "Gene expression and lung tumors: screening for markers that discriminate tumor histology and genetic background.", "resolution_checked_at": "2026-11-01T15:39:55Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE8894", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE8894", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE8894", "version": null, "note": "The original contributions presented in the study are included in the article/ Supplementary Material . Further inquiries can be directed to the corresponding authors.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The original contributions presented in the study are included in the article/ Supplementary Material . Further inquiries can be directed to the corresponding authors.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM225465", "GSM225530", "GSM225544", "GSM225547", "GSM225552", "GSM225553", "GSM225556", "GSM225558", "GSM225563", "GSM225565", "GSM225568", "GSM225572", "GSM225574", "GSM225575", "GSM225578", "GSM225582", "GSM225584", "GSM225585", "GSM225586", "GSM225587", "GSM225589", "GSM225590", "GSM225591", "GSM225593", "GSM225594", "GSM225595", "GSM225596", "GSM225598", "GSM225599", "GSM225601", "GSM225603", "GSM225604", "GSM225765", "GSM225766", "GSM225767", "GSM225768", "GSM225769", "GSM225770", "GSM225771", "GSM225772", "GSM225773", "GSM225774", "GSM225775", "GSM225776", "GSM225777", "GSM225778", "GSM225779", "GSM225780", "GSM225781", "GSM225782", "GSM225783", "GSM225784", "GSM225785", "GSM225786", "GSM225787", "GSM225788", "GSM225789", "GSM225790", "GSM225791", "GSM225792", "GSM225793", "GSM225794", "GSM225795", "GSM225796", "GSM225797", "GSM225798", "GSM225799", "GSM225800", "GSM225801", "GSM225802", "GSM225803", "GSM225804", "GSM225805", "GSM225806", "GSM225807", "GSM225808", "GSM225809", "GSM225810", "GSM225811", "GSM225812", "GSM225813", "GSM225814", "GSM225815", "GSM225816", "GSM225817", "GSM225818", "GSM225819", "GSM225820", "GSM225821", "GSM225823", "GSM225824", "GSM225825", "GSM225827", "GSM225828", "GSM225829", "GSM225831", "GSM225832", "GSM225833", "GSM225835", "GSM225836", "GSM225844", "GSM225846", "GSM225848", "GSM225849", "GSM225851", "GSM225852", "GSM225854", "GSM225855", "GSM225857", "GSM225859", "GSM225861", "GSM225863", "GSM225864", "GSM225866", "GSM225868", "GSM225873", "GSM225874", "GSM225876", "GSM225877", "GSM225879", "GSM225880", "GSM225882", "GSM225883", "GSM225884", "GSM225886", "GSM225888", "GSM225889", "GSM225890", "GSM225893", "GSM225894", "GSM225895", "GSM225896", "GSM225897", "GSM225898", "GSM225899", "GSM225900", "GSM225901", "GSM225902"], "sample_count": 138, "group_sizes": null, "group_sizes_basis": null, "platform": "570", "taxon": "Homo sapiens", "title": "Prediction of Recurrence-Free Survival in Postoperative NSCLC Patients—a Useful Prospective Clinical Practice", "resolution_checked_at": "2026-11-01T15:39:55Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "asset:table:pmid:34026630:1", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:fb0832383c0a41ce60ec3e55b93aed548dbf056b641a07f7d2abe8ad43495629", "bytes": 938, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[5]/table-wrap[1]#T1", "version": null, "note": "Information of GEO series included in this analysis.", "structure": {"pmcid": "PMC8138120", "section_index": 5, "section_title": "Data Collection", "row_count": 9, "column_count": 5}, "table": {"label": "Table 1", "caption": "Information of GEO series included in this analysis.", "rows": [["GEO series", "Contributor(s)", "Tumor", "Normal", "Platform"], ["GSE8569", "Angulo et al., 2007", "69", "6", "CNIO Human Oncochip 2.0"], ["GSE101929", "Mitchell et al., 2017", "32", "34", "Affymetrix Human Genome U133 Plus 2.0 Array"], ["GSE33532", "Meister et al., 2011", "80", "20", "Affymetrix Human Genome U133 Plus 2.0 Array"], ["GSE27262", "Li-Jen et al., 2011", "25", "25", "Affymetrix Human Genome U133 Plus 2.0 Array"], ["GSE21933", "Chang et al., 2010", "21", "21", "Phalanx Human OneArray"], ["GSE19804", "Lu et al., 2010", "60", "60", "Affymetrix Human Genome U133 Plus 2.0 Array"], ["GSE19188", "Philipsen, 2009", "91", "65", "Affymetrix Human Genome U133 Plus 2.0 Array"], ["GSE18842", "Ramos et al., 2019", "46", "45", "Affymetrix Human Genome U133 Plus 2.0 Array"]], "row_count": 9, "column_count": 5, "numeric_cells": 39, "header_rows": 1, "locator": "section[5]/table-wrap[1]#T1"}}, {"id": "asset:table:pmid:34026630:2", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:5bb2661bb89ee69dac299324168f24bcb3b43ae517985a41eda81192cad3504a", "bytes": 1732, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[18]/table-wrap[1]#T2", "version": null, "note": "The Kinase, miRNA and transcription factor-target networks of MRPL15 in NSCLC (LinkedOmics).", "structure": {"pmcid": "PMC8138120", "section_index": 18, "section_title": "Regulators of MRPL15 Networks in NSCLC", "row_count": 20, "column_count": 7}, "table": {"label": "Table 2", "caption": "The Kinase, miRNA and transcription factor-target networks of MRPL15 in NSCLC (LinkedOmics).", "rows": [["Enriched Category", "LUAD", "LUSC"], ["", "Geneset", "LeadingEdgeNum", "FDR", "Geneset", "LeadingEdgeNum", "FDR"], ["Kinase Target", "Kinase_HCK", "14", "0", "Kinase_MAPK7", "17", "0.026220"], ["", "Kinase_PLK1", "33", "0.001544", "Kinase_HCK", "13", "0.026220"], ["", "Kinase_AURKB", "35", "0.006952", "Kinase_PRKAA2", "11", "0.030590"], ["", "Kinase_PLK3", "10", "0.011844", "Kinase_MAPK10", "9", "0.030590"], ["", "Kinase_CDK1", "85", "0.018153", "Kinase_MAPK3", "67", "0.031561"], ["miRNA Target", "ATGTACA,MIR-493", "115", "0", "TTTGCAC,MIR-19A,MIR-19B", "178", "0"], ["", "GTGCAAA,MIR-507", "51", "0", "GTGCAAA,MIR-507", "49", "0"], ["", "TTTGCAC,MIR-19A,MIR-19B", "162", "0", "TTGCACT,MIR-130A,MIR-301,MIR-130B", "144", "0"], ["", "GCACCTT,MIR-18A,MIR-18B", "53", "0", "TGCACTT,MIR-519C,MIR-519B,MIR-519A", "149", "0"], ["", "TGCACTT,MIR-519C,MIR-519B,MIR-519A", "124", "0", "GCACCTT,MIR-18A,MIR-18B", "52", "0"], ["", "GCACTTT,MIR-17-5P,MIR-20A,MIR-106A,MIR-106B,MIR-20B,MIR-519D", "185", "0", "GCACTTT,MIR-17-5P,MIR-20A,MIR-106A,MIR-106B,MIR-20B,MIR-519D", "202", "0"], ["", "GAGCCTG,MIR-484", "45", "0", "GAGCCTG,MIR-484", "60", "0"], ["", "TTGCACT,MIR-130A,MIR-301,MIR-130B", "124", "0", "ATGTACA,MIR-493", "121", "0"], ["Transcription Factor Target", "V$ELK1_02", "72", "0", "GGAANCGGAANY_UNKNOWN", "39", "0"], ["", "SCGGAAGY_V$ELK1_02", "348", "0", "SCGGAAGY_V$ELK1_02", "316", "2.82E-04"], ["", "GGAANCGGAANY_UNKNOWN", "39", "0", "TMTCGCGANR_UNKNOWN", "55", "8.47E-04"], ["", "TMTCGCGANR_UNKNOWN", "44", "0", "V$ELK1_02", "75", "9.42E-04"], ["", "V$DBP_Q6", "68", "0", "AAAYWAACM_V$HFH4_01", "77", "0.001939"]], "row_count": 20, "column_count": 7, "numeric_cells": 94, "header_rows": 2, "locator": "section[18]/table-wrap[1]#T2"}}, {"id": "asset:table:pmid:34026630:3", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:21ed767a4d028a3a773ff898b279ae45e24741869c74bd5ceb11a1e995d478da", "bytes": 1485, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[20]/table-wrap[1]#T3", "version": null, "note": "Correlation between MRPL15 expression and clinicopathological characteristics in lung cancer patients.", "structure": {"pmcid": "PMC8138120", "section_index": 20, "section_title": "The Prognostic Value of MRPL15 Expression in Lung Cancer Patients", "row_count": 25, "column_count": 6}, "table": {"label": "Table 3", "caption": "Correlation between MRPL15 expression and clinicopathological characteristics in lung cancer patients.", "rows": [["Characteristics", "total", "MRPL15 expression", "Chi-square", "P"], ["Patient", "91", "low", "high"], ["48", "43", "", ""], ["Age", "", "", "", "", "0.104"], ["<60", "33 (36.3%)", "14 (29.2%)", "19 (44.2%)", "2.21", "0.137"], ["≥60", "58 (63.7%)", "34 (70.8%)", "24 (55.8%)"], ["Gender", "", "", "", "", ""], ["Male", "51 (44%)", "30 (37.5%)", "21 (51.2%)", "1.719", "0.19"], ["Female", "40 (56%)", "18 (62.5%)", "22 (48.8%)"], ["Pathological type", "", "", "", "", ""], ["Adenocarcinoma", "67 (73.6%)", "31 (64.6%)", "36 (83.7%)", "4.33", "0.115"], ["Bronchioloalveolar Carcinoma", "6 (6.6%)", "4 (8.3%)", "2 (4.7%)"], ["Adenocarcinoma with other tissue", "18 (19.8%)", "13 (27.1%)", "5 (11.6%)"], ["Clinical stage", "", "", "", "", ""], ["I–II", "57 (62.6%)", "33 (68.8%)", "24 (55.8%)", "1.622", "0.203"], ["III–IV", "34 (37.4%)", "15 (31.2%)", "19 (44.2%)"], ["T classification", "", "", "", "", ""], ["T1–T2", "68 (74.7%)", "37 (77.1%)", "31 (72.1%)", "0.299", "0.584"], ["T3–T4", "23 (25.3%)", "11 (22.9%)", "12 (21.9%)"], ["N classification", "", "", "", "", ""], ["N negative", "39 (42.9%)", "25 (52.1%)", "14 (32.6%)", "3.531", "0.028"], ["N positive", "52 (57.1%)", "23 (47.9%)", "29 (67.4%)"], ["M classification", "", "", "", "", ""], ["M0", "89 (97.8%)", "48 (100%)", "41 (95.3%)", "", "0.221"], ["M1", "2 (2.2%)", "0 (0%)", "2 (4.7%)"]], "row_count": 25, "column_count": 6, "numeric_cells": 65, "header_rows": 3, "locator": "section[20]/table-wrap[1]#T3"}}, {"id": "asset:table:pmid:34026630:4", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:d6acbf14463b70bd33d6309ba5b3aba4a2111db972a6fc1add3aad8ed67fff75", "bytes": 1325, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[20]/table-wrap[2]#T4", "version": null, "note": "Univariate and multivariate Cox regression analysis.", "structure": {"pmcid": "PMC8138120", "section_index": 20, "section_title": "The Prognostic Value of MRPL15 Expression in Lung Cancer Patients", "row_count": 18, "column_count": 7}, "table": {"label": "Table 4", "caption": "Univariate and multivariate Cox regression analysis.", "rows": [["Variables", "Univariate Analysis", "Multivariate Analysis"], ["HR", "95% CI", "P value", "HR", "95% CI", "P value"], ["Gender", "1.491", "0.85–2.618", "0.164", "1.05", "1.017–1.084", "0.003"], ["Age", "1.039", "1.007–1.071", "0.017", "", "", ""], ["Clinical stage (I)", "", "", "0.017", "", "", ""], ["Clinical stage (II)", "1.116", "0.509–2.448", "0.784", "", "", ""], ["Clinical stage (III)", "2.545", "1.275–5.081", "0.008", "", "", ""], ["Clinical stage (IV)", "3.846", "0.848–17.442", "0.081", "", "", ""], ["T classification (T1)", "", "", "0.006", "", "", ""], ["T classification (T2)", "1.883", "0.866–4.094", "0.11", "", "", ""], ["T classification (T3)", "4.479", "1.823–11.006", "0.001", "", "", ""], ["T classification (T4)", "3.383", "1.252–9.138", "0.016", "", "", ""], ["N classification", "", "", "0.055", "", "", ""], ["N classification (1)", "1.243", "0.625–2.47", "0.535", "", "", ""], ["N classification (2)", "2.773", "1.298–5.925", "0.008", "", "", ""], ["N classification (3)", "1.866", "0.737–4.727", "0.188", "", "", ""], ["M classification (M0vsM1)", "2.482", "0.595–10.357", "0.212", "", "", ""], ["MRPL15 expression", "1.895", "1.083–3.316", "0.025", "1.996", "1.121–3.554", "0.019"]], "row_count": 18, "column_count": 7, "numeric_cells": 54, "header_rows": 2, "locator": "section[20]/table-wrap[2]#T4"}}], "gaps": ["asset:data:geo:GSE101929 not downloaded", "asset:data:geo:GSE101929 licence not read", "asset:data:geo:GSE13213 not downloaded", "asset:data:geo:GSE13213 licence not read", "asset:data:geo:GSE18842 not downloaded", "asset:data:geo:GSE18842 licence not read", "asset:data:geo:GSE19188 not downloaded", "asset:data:geo:GSE19188 licence not read", "asset:data:geo:GSE19804 not downloaded", "asset:data:geo:GSE19804 licence not read", "asset:data:geo:GSE21933 not downloaded", "asset:data:geo:GSE21933 licence not read", "asset:data:geo:GSE27262 not downloaded", "asset:data:geo:GSE27262 licence not read", "asset:data:geo:GSE31210 not downloaded", "asset:data:geo:GSE31210 licence not read", "asset:data:geo:GSE33532 not downloaded", "asset:data:geo:GSE33532 licence not read", "asset:data:geo:GSE8569 not downloaded", "asset:data:geo:GSE8569 licence not read", "asset:data:geo:GSE8894 not downloaded", "asset:data:geo:GSE8894 licence not read"]}, "analysis": {"state": "complete", "methods": [{"id": "method-1", "family": "survival_analysis", "specific": "kaplan_meier", "label": "Survival analysis", "dsl_operations": ["survival_km"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["time_to_event_with_censoring"], "evidence": {"score": 0.7, "band": "medium", "quote": "Kaplan-Meier"}}, {"id": "method-2", "family": "survival_analysis", "specific": "cox_proportional_hazards", "label": "Survival analysis", "dsl_operations": ["cox_ph"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["time_to_event_with_censoring"], "evidence": {"score": 0.8, "band": "high", "quote": "Cox regression"}}, {"id": "method-3", "family": "survival_analysis", "specific": "log_rank_test", "label": "Survival analysis", "dsl_operations": ["logrank_test"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["time_to_event_with_censoring"], "evidence": {"score": 0.8, "band": "high", "quote": "log-rank"}}, {"id": "method-4", "family": "network_analysis", "specific": "ppi_network", "label": "Network / pathway analysis", "dsl_operations": ["build_graph", "centrality_scores", "pathway_enrich"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["edge_list"], "evidence": {"score": 0.8, "band": "high", "quote": "PPI"}}, {"id": "method-5", "family": "contingency_analysis", "specific": "chi_square", "label": "Categorical (contingency table) analysis", "dsl_operations": ["chi_square_test"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["categorical_cross_tabulation"], "evidence": {"score": 0.8, "band": "high", "quote": "Chi-square"}}], "targets": [], "gaps": []}, "capability": {"state": "complete", "requirements": [{"capability_id": "capability:computational_analysis", "label": "Computational analysis platform", "assay_families": ["meta_analysis", "machine_learning", "survival_analysis", "statistical_regression", "pca", "molecular_docking", "network_analysis", "differential_expression", "gwas"], "availability_state": "owned", "tier_unlocked": "R1", "candidate": "Automated Assays Laravel application and simulated adapters"}], "gaps": []}, "readiness": {"state": "complete", "tier": "R1", "blocking_axis": "none", "blocked_on": "nothing:replicable_now", "axes": {"method": {"tier": "R1", "expressible": true, "required_operations": ["survival_km"], "missing_operations": [], "basis": "The paper names the method it used and the corpus's method extractor maps it onto the DSL catalogue: kaplan_meier."}, "capability": {"tier": "R1", "capability_id": "capability:computational_analysis", "availability_state": "owned", "basis": "The computational analysis is owned. The physical bench the paper used is not, so a physical validation cannot be run here."}, "data": {"tier": "R1", "reachable": true, "accessions": ["GSE8569", "GSE101929", "GSE33532", "GSE27262", "GSE21933", "GSE19804", "GSE19188", "GSE18842", "GSE8894", "GSE31210", "GSE13213"], "resolved_accessions": ["GSE8569", "GSE101929", "GSE33532", "GSE27262", "GSE21933", "GSE19804", "GSE19188", "GSE18842", "GSE8894", "GSE31210", "GSE13213"], "statements": ["The original contributions presented in the study are included in the article/ Supplementary Material . Further inquiries can be directed to the corresponding authors."], "basis": "The paper names GSE8569, GSE101929, GSE33532, GSE27262, GSE21933, GSE19804, GSE19188, GSE18842, GSE8894, GSE31210, GSE13213 in Gene Expression Omnibus (GEO) and the accession resolves in the repository. No dataset was downloaded and no licence was read."}}, "can_run": {"dsl_operations": ["survival_km"], "assets": ["source:pmid:34026630", "data:geo:GSE101929", "asset:table:pmid:34026630:1", "asset:table:pmid:34026630:2", "asset:table:pmid:34026630:3", "asset:table:pmid:34026630:4"], "steps": ["run_analysis"]}, "must_build": {"dsl_operations": [], "converters": [], "readers": [], "capabilities": [], "data_gaps": ["data:geo:GSE101929"]}, "gaps": []}, "review": {"state": "partial", "machine_critique": {"kind": "extraction_review", "reader": {"model": "MiniMax-M3.1-Flash", "provider": "minimax", "provider_family": "minimax", "read_at": "2026-10-31T19:35:19Z", "independence": "single_reader"}, "evidence_check": {"method": "absent", "availability": "verbatim"}, "calls": 3, "usage": {"prompt_tokens": 23769, "completion_tokens": 3199, "cached_tokens": 520}}, "human_critique": null, "stages": [{"id": "extraction", "state": "complete", "reader": "MiniMax-M3.1-Flash", "provider": "minimax"}], "gaps": ["review.independent_reader", "review.machine_critique", "review.human_critique"]}, "execution": {"state": "absent", "status": "not_run", "mode": null, "runs": [], "gaps": ["execution.not_run"]}, "provenance": {"entities": [{"id": "pmid:34026630", "type": "paper", "label": "pmid:34026630"}, {"id": "source:pmid:34026630", "type": "manuscript", "label": "PMID 34026630 full text"}, {"id": "data:geo:GSE101929", "type": "dataset", "label": "GEO GSE101929"}], "activities": [{"id": "activity-reading-sci-2026-11-01", "type": "classification", "used": [{"id": "pmid:34026630", "type": "paper", "label": "pmid:34026630"}, {"id": "source:pmid:34026630", "type": "manuscript", "label": "PMID 34026630 full text"}, {"id": "data:geo:GSE101929", "type": "dataset", "label": "GEO GSE101929"}], "agent": "agent:corpus-assay-engine"}, {"id": "activity-read-34026630", "type": "extraction", "used": ["source:pmid:34026630"], "agent": "agent:minimax-reader"}, {"id": "activity-resolve-GSE101929", "type": "accession_resolution", "used": ["data:geo:GSE101929"], "agent": "agent:corpus-assay-engine"}], "agents": [{"id": "agent:corpus-assay-engine", "type": "software", "label": "Corpus assay engine"}, {"id": "agent:minimax-reader", "type": "software", "label": "MiniMax literature reader"}], "source_run_id": "reading-sci-2026-11-01", "dsl_catalogue_fingerprint": "343fb30756ba6ec3", "capability_table_fingerprint": "2cb3e42f047d2ecf", "snapshot_id": "ba34b49490d9bfaf"}, "lineage": {"parent_id": "pmid:34026630", "parent_hash": "sha256:347ccb485c19e972cbee16d2ebec9887a059e7ab3a7f0cc3e04c63248dddec44", "fork_of": null, "generation": 6}, "gaps": ["asset:data:geo:GSE101929 licence not read", "asset:data:geo:GSE101929 not downloaded", "asset:data:geo:GSE13213 licence not read", "asset:data:geo:GSE13213 not downloaded", "asset:data:geo:GSE18842 licence not read", "asset:data:geo:GSE18842 not downloaded", "asset:data:geo:GSE19188 licence not read", "asset:data:geo:GSE19188 not downloaded", "asset:data:geo:GSE19804 licence not read", "asset:data:geo:GSE19804 not downloaded", "asset:data:geo:GSE21933 licence not read", "asset:data:geo:GSE21933 not downloaded", "asset:data:geo:GSE27262 licence not read", "asset:data:geo:GSE27262 not downloaded", "asset:data:geo:GSE31210 licence not read", "asset:data:geo:GSE31210 not downloaded", "asset:data:geo:GSE33532 licence not read", "asset:data:geo:GSE33532 not downloaded", "asset:data:geo:GSE8569 licence not read", "asset:data:geo:GSE8569 not downloaded", "asset:data:geo:GSE8894 licence not read", "asset:data:geo:GSE8894 not downloaded", "execution.not_run", "review.human_critique", "review.independent_reader", "review.machine_critique"], "assays": [{"role": "data_generation", "definition_id": "ihc", "definition_version": "99e1195c7d6f", "definition_digest": null, "required_operations": [], "support_state": "partial", "source_hashes": {"assay_lexicon": "99e1195c7d6f"}, "confidence": 0.99, "evidence": ["of MRPL15 in lung cancer were validated via immunohistochemistry (IHC) assays. RESULTS: In NSCLC, multiple co", "cer were validated via immunohistochemistry (IHC) assays. RESULTS: In NSCLC, multiple cohorts", "nfiltrating lymphocytes (TILs). Furthermore, IHC results further confirmed the high MRPL15 ex", "rrays. (A) Representative pictures of MRPL15 IHC in lung cancer tissues and matched adjacent"], "order_basis": "paper_text_order:734", "id": "assay:1"}, {"role": "analysis", "definition_id": "survival_analysis", "definition_version": "f2132e96ae6c7a4e", "definition_digest": null, "required_operations": ["survival_km"], "support_state": "supported", "source_hashes": {"dsl_catalogue": "f2132e96ae6c7a4e"}, "confidence": 0.7, "evidence": ["Kaplan-Meier"], "order_basis": "consumes_earlier_output", "id": "assay:2"}]}