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pmid:34140574
DCBLD1 is associated with the integrin signaling pathway and has prognostic value in non-small cell lung and invasive breast carcinoma.
Guillaume B Cardin · Monique Bernard · Francis Rodier · Apostolos Christopoulos
Scientific reports · 2021 doi:10.1038/s41598-021-92090-6
Paper
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Experiment
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Data
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Analysis
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Execution
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Complete file
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However the clinical relevance and function of DCBLD1 remain unclear. This multicenter retrospective study was designed to evaluate the prognostic value and function of DCBLD1 in the four main solid cancers: NSCLC, invasive breast carcinoma, colorectal adenocarcinoma and prostate adenocarcinoma. We included the following cohorts: GSE81089 NSCLC, METABRIC invasive breast carcinoma, GSE14333 colorectal adenocarcinoma, GSE70770 prostate adenocarcinoma and The Cancer Genome Atlas (TCGA) Firehose Legacy cohorts of all four cancers. DCBLD1 gene expression was associated with a worse overall survival in multivariate analyses for both NSCLC cohorts (TCGA: P = 0.03 and GSE81089: P = 0.04) and both invasive breast carcinoma cohorts (TCGA: P = 0.02 and METABRIC: P < 0.001). 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[["", "NSCLC TCGA", "NSCLC GSE81089", "Breast TCGA", "Breast METABRIC", "Colorectal TCGA", "Colorectal GSE14333", "Prostate TCGA", "Prostate GSE70770"], ["Total, n", "1001", "199", "1091", "1900", "372", "236", "496", "203"], ["Age, median (range)", "67 (38–90)", "69 (45–84)", "58 (26–90)", "61 (21–96)", "66 (31–90)", "67 (26–92)", "61 (41–78)", "62 (41–73)"], ["Sex, n (%)"], ["Female", "400 (40)", "103 (52)", "1079 (99)", "1900 (100)", "166 (45)", "112 (47)", "0", "0"], ["Male", "601 (60)", "96 (48)", "12 (1)", "0", "206 (55)", "124 (53)", "496 (100)", "203 (100)"], ["Stage, n (%)"], ["1", "513 (51)", "115 (58)", "180 (16)", "475 (25)", "56 (15)", "45 (19)", "37 (7)", "11 (5)"], ["2", "279 (28)", "48 (24)", "618 (57)", "800 (42)", "134 (36)", "100 (42)", "339 (68)", "72 (35)"], ["3", "164 (16)", "33 (17)", "249 (23)", "115 (6)", "112 (30)", "91 (39)", "39 (8)", "107 (53)"], ["4", "33 (3)", "3 (2)", "20 (2)", "9 (0)", "52 (14)", "0 (0)", "81 (16)", "13 (6)"], ["NA", "25 (2)", "0 (0)", "24 (2)", "501 (26)", "18 (5)", "0 (0)", "0 (0)", "0 (0)"], ["Follow-up, months (median)", "21.5", "36.4", "27.8", "115.6", "22.1", "38.1", "30.5", "36.7"], ["Tobacco use, n (%)"], ["Ever smoker", "885 (88)", "180 (90)", "–", "–", "–", "–", "–", "–"], ["Never smoker", "91 (9)", "19 (10)", "–", "–", "–", "–", "–", "–"], ["NA", "25 (2)", "0", "–", "–", "–", "–", "–", "–"], ["NSCLC histology, n (%)"], ["Adenocarcinoma", "506 (51)", "108 (54)", "–", "–", "–", "–", "–", "–"], ["Squamous cell carcinoma", "495 (49)", "67 (34)", "–", "–", "–", "–", "–", "–"], ["NA", "0", "24 (12)", "–", "–", "–", "–", "–", "–"], ["PAM50 subtype, n (%)"], ["Luminal A", "–", "–", "413 (38)", "679 (36)", "–", "–", "–", "–"], ["Luminal B", "–", "–", "174 (16)", "460 (24)", "–", "–", "–", "–"], ["HER2-enriched", "–", "–", "65 (6)", "218 (11)", "–", "–", "–", "–"], ["Basal-like", "–", "–", "136 (12)", "397 (21)", "–", "–", "–", "–"], ["Normal-like", "–", "–", "25 (2)", "140 (7)", "–", "–", "–", "–"], ["NA", "–", "–", "278 (25)", "6 (0)", "–", "–", "–", "–"]], "row_count": 28, "column_count": 9, "numeric_cells": 112, "header_rows": 1, "locator": "section[3]/table-wrap[1]#Tab1"}}, {"id": "asset:table:pmid:34140574:2", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:5965e39e5d4f051de70f087faa3c99c1d8105fd96e9112d9b4062d95c184d870", "bytes": 1763, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[4]/table-wrap[1]#Tab2", "version": null, "note": "Multivariate Cox proportional hazards analysis of cancer outcomes.", "structure": {"pmcid": "PMC8211811", "section_index": 4, "section_title": "DCBLD1 gene expression and cancer outcome", "row_count": 23, "column_count": 5}, "table": {"label": "Table 2", "caption": "Multivariate Cox proportional hazards analysis of cancer outcomes.", "rows": [["Variable", "HR (95% CI)", "P", "HR (95% CI)", "P"], ["Non-small cell lung 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