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pmid:34178625
Construction and Validation of a Universal Applicable Prognostic Signature for Gastric Cancer Based on Seven Immune-Related Gene Correlated With Tumor Associated Macrophages.
Junyu Huo · Liqun Wu · Yunjin Zang
Frontiers in oncology · 2021 doi:10.3389/fonc.2021.635324
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Experiment
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Complete file
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A risk score was constructed based on univariate Cox analysis and Lasso penalized Cox regression analysis in the TCGA cohort (n=341). The optimal cutoff determined by the 5-year time-dependent receiver operating characteristic (ROC) curve was considered to classify patients into groups with high and low risk. We conducted external validation of the prognostic signature in four independent cohorts (GSE84437, n=431; GSE62254, n=300; GSE15459, n=191; and GSE26901, n=109) from the Gene Expression Omnibus (GEO) database.\nRESULTS: The signature consisting of 7 genes (FGF1, GRP, AVPR1A, APOD, PDGFRL, CXCR4, and CSF1R) showed good performance in predicting overall survival (OS) in the 5 independent cohorts. The risk score presented an obviously positive correlation with macrophage abundance (cor=0.7, p<0.001). A significant difference was found between the high- and low-risk groups regarding the overall survival of GC patients. The high-risk group exhibited a higher infiltration level of M2 macrophages estimated by the CIBERSORT algorithm. In the five independent cohorts, the risk score was highly positively correlated with the stromal cell score, suggesting that we can also evaluate the infiltration of stromal cells in the tumor microenvironment according to the risk score.\nCONCLUSION: Our study developed and validated a general applicable prognostic model for GC from the perspective of TAMs, which may help to improve the precise treatment strategy of GC.", "claims": [{"id": "claim-method", "statement": "A total of 283 DEIRGs were identified by the Wilcox test in the “limma” R package ( Figure 2B ).", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:34178625", "locator": "sections[12] \"Identification of DEIRGs Associated With Macrophage Infiltration\" paragraph 2", "quote": "A total of 283 DEIRGs were identified by the Wilcox test in the “limma” R package ( Figure 2B )."}], "state": "complete"}, {"id": "claim-data-access", "statement": "Publicly available datasets were analyzed in this study. 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