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pmid:34179317
The transcriptome of circulating cells indicates potential biomarkers and therapeutic targets in the course of hypertension-related myocardial infarction.
Zilun Wei · Yining Yang · Qiaoling Li · Yong Yin · Zhonghai Wei · Wenfeng Zhang · Dan Mu · Jie Ni · Xuan Sun · Biao Xu
Genes & diseases · 2021 doi:10.1016/j.gendis.2020.01.007
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Complete file
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Cardiovascular diseases are the leading cause of mortality and morbidity among the elderly (age > 65 years) in the United States. Now, there is widespread acceptance of the causal link between HT and acute myocardial infarction (MI). This is the first data-mining study to identify co-expressed differentially expressed genes (co-DEGs) between HT and MI (relative to normal control) and to uncover potential biomarkers and therapeutic targets of HT-related MI. In this manuscript, HT-specific DEGs and MI-specific DEGs and differentially expressed microRNAs (DE-miRNAs) were identified in Gene Expression Omnibus (GEO) datasets GSE24752, GSE60993, GSE62646, and GSE24548 after data consolidation and batch correction. 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