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pmid:34210950
Exploration of the Important Role of Microfibril-Associated Protein 4 Gene in Oral Squamous Cell Carcinoma.
Ying Han · Kun Xia · Tong Su
Medical science monitor : international medical journal of experimental and clinical research · 2021 doi:10.12659/MSM.931238
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Complete file
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Currently, there are no molecular biomarkers to guide these treatment strategies. Studies have shown that microfibril-associated protein 4 (MFAP4) is potentially useful for non-invasive assessment of various diseases; however, its biological function in tumors is still unknown. In this study, we propose that MFAP4 is a new prognostic target for OSCC. MATERIAL AND METHODS First, we collected OSCC data (GSE25099 and GSE30784 datasets) from the Gene Expression Omnibus (GEO) database and compared the differential expression of MFAP4 gene between the patients (tumor) and normal (control) groups. The comparison was done with University of California Santa Cruz Xena (https://xenabrowser.net/Datapages/), and we calculated the difference in MFAP4 gene expression between normal and tumor tissues in a pan-cancer analysis. Then, we compared the 2 groups with high and low expression of MFAP4 gene in terms of tumor mutation burden (TMB), miRNA regulation, and immune cell infiltration. RESULTS We found that the expression of MFAP4 gene was significantly decreased in tumors. Our research also showed that high expression of MFAP4 was related to better prognosis of patients and may be related to tumor gene mutation, miRNA regulation, and infiltration of different immune cells. CONCLUSIONS Our work provides evidence that expression of MFAP4 can be used as a prognostic biomarker for risk stratification of OSCC patients and elaborates on its relation with the regulation of TMB, miRNAs, and immune cell infiltration.", "claims": [{"id": "claim-method", "statement": "With the criteria set as |logFC| >2 and P value <0.05, 23 differential miRNAs were included in the Pearson correlation analysis of the relationship between miRNA and MFAP4 in both the high- and low-MFAP4 expression groups.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:34210950", "locator": "sections[16] \"Identification of miRNAs Related to MFAP4\" paragraph 2", "quote": "With the criteria set as |logFC| >2 and P value <0.05, 23 differential miRNAs were included in the Pearson correlation analysis of the relationship between miRNA and MFAP4 in both the high- and low-MFAP4 expression groups."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The data of this study are from the GEO and TCGA databases.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:34210950", "locator": "sections[24] \"Footnotes\" paragraph 2", "quote": "The data of this study are from the GEO and TCGA databases."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": null, "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:34210950"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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