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pmid:34248362

Real-World Outcomes and Clinical Predictors of Immune Checkpoint Inhibitor Monotherapy in Advanced Lung Cancer

Clinical Medicine Insights. Oncology · 2021 doi:10.1177/11795549211004489

Paper

partial

Experiment

partial

Data

partial

Analysis

partial

Execution

absent

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Record details sci_version · id · kind · revision · content_hash · schema · created_at · updated_at · generator
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Real-World Outcomes and Clinical Predictors of Immune Checkpoint Inhibitor Monotherapy in Advanced Lung Cancer
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10.1177/11795549211004489
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34248362
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null
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Clinical Medicine Insights. Oncology
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2021
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the median overall survival of patients with advanced non-small-cell lung cancer treated with immune checkpoint inhibitor monotherapy
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In the NSCLC cohort, the objective response rate (ORR) was 32.0% (95% CI, 25.6%-39.0%). Ten (5.0%) patients had complete response, and 54 (27.0%) had partial response (Table 3). Median PFS was 3.8 months (4.7 months for first-line therapy and 3.7 months for subsequent-line therapy). The estimated rate of PFS was 38.8% at 6 months, 27.8% at 12 months, and 18.2% at 24 months (Figure 1). Median OS was 12.4 months (15.6 months for first-line therapy and 11.5 months for subsequent-line therapy).
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the median overall survival of patients with advanced non-small-cell lung cancer treated with immune checkpoint inhibitor monotherapy
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Cox proportional hazard regression analysis of the effect of various parameters on progression-free survival and overall survival.
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Predictive factors associated with survival outcomes in NSCLC
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Medical records of patients with advanced lung cancer who started ICI monotherapy were reviewed for data collection. Treatment outcomes included objective response rate, progression-free survival (PFS), and overall survival (OS). Immune-related adverse events (irAEs) were assessed. Multiple Cox regression models were fit to investigate the predictive factors for survival outcomes.
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In the NSCLC cohort, the objective response rate (ORR) was 32.0% (95% CI, 25.6%-39.0%). Ten (5.0%) patients had complete response, and 54 (27.0%) had partial response (Table 3). Median PFS was 3.8 months (4.7 months for first-line therapy and 3.7 months for subsequent-line therapy). The estimated rate of PFS was 38.8% at 6 months, 27.8% at 12 months, and 18.2% at 24 months (Figure 1). Median OS was 12.4 months (15.6 months for first-line therapy and 11.5 months for subsequent-line therapy).
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lineage object · 4 fields
parent_id
pmid:34248362
parent_hash
sha256:4d38fd2f33287ea1d7f6070b05ce902811ad5ab84633a9d5d8bce674adafe941
fork_of
null
gaps array · 13 items
[0]
abstract
[1]
asset:materials:the analysis programme that recomputes the published estimate not verified
[2]
asset:materials:the source data behind the published result in pmid:34248362 not verified
[3]
asset:source:pmid:34248362 not verified
[4]
authors
[5]
capability:capability:bench_workcell purchasable
[6]
data:accession_absent
[7]
execution.not_run
[8]
review.human_critique
[9]
review.machine_critique.passed
[10]
step:obtain_source_data blocked on data:accession_absent
[11]
step:provide_capability_bench_workcell blocked on instrument not yet purchased
[12]
step:run_analysis blocked on method:epidemiological_modelling_incidence_rate
Complete file
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