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pmid:34248362
Real-World Outcomes and Clinical Predictors of Immune Checkpoint Inhibitor Monotherapy in Advanced Lung Cancer
Clinical Medicine Insights. Oncology · 2021 doi:10.1177/11795549211004489
Paper
partial
Experiment
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Data
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Analysis
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Execution
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Complete file
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Median OS was 12.4 months (15.6 months for first line therapy and 11.5 months for subsequent line).", "target_result": "Median overall survival was 12.4 months.", "number_stated": true, "source_locator": "chars 1044-1243 of source sha256 c896e7fb83e4c1316132a9d317c903bc2ede63bdfd73689c1cc743353dd42eaf"}, "recorded_at": "2026-10-31T14:36:10.722441+00:00"}], "agreement": true, "disagreements": {"target_result": {"minimax-m3-1-flash": "Median overall survival was 12.4 months in patients with advanced NSCLC treated with immune checkpoint inhibitor monotherapy.", "minimax-m3": "Median overall survival was 12.4 months in the advanced NSCLC cohort treated with immune checkpoint inhibitor monotherapy.", "decisive": false}, "analysis_methods": {"minimax-m3-1-flash": ["Kaplan-Meier estimation of overall survival", "Multiple Cox regression analysis"], "minimax-m3": ["Retrospective medical-record review of a consecutive advanced lung cancer cohort", "Kaplan-Meier estimation of overall survival and progression-free survival", "Multiple Cox regression modeling of prognostic factors for survival outcomes"], "decisive": false}, "source_claims": {"minimax-m3-1-flash": ["In the NSCLC cohort, median PFS was 3.8 months (4.7 months for first-line therapy and 3.7 months for subsequent-line therapy).", "Median OS was 12.4 months (15.6 months for first-line therapy and 11.5 months for subsequent-line therapy).", "Overall survival (OS) was defined as time from the start of ICI treatment to death due to any cause.", "Kaplan-Meier curves were calculated for OS and PFS."], "minimax-m3": ["The study retrospectively reviewed medical records of 220 patients with advanced lung cancer who received single-agent atezolizumab, nivolumab, or pembrolizumab.", "In the NSCLC cohort, median OS was 12.4 months.", "Median OS was 15.6 months for first-line therapy and 11.5 months for subsequent-line therapy.", "Kaplan-Meier curves were calculated for OS and PFS, and Cox regression was used to model prognostic factors."], "decisive": false}}, "agreement_basis": {"policy": "decisive_fields", "decisive_fields": ["number_stated", "parent_value", "unit", "work_type"], "advisory_fields": ["analysis_methods", "source_claims", "target_result"]}, "blinded": true}, "human_critique": {"status": "not_run", "reviewer": null, "signed_at": null, "conflict_checked": false, "commentary": null}, "stages": [{"key": "target_materials", "status": "pending", "reason": null, "evidence": null}, {"key": "independent_readings", "status": "passed", "reason": null, "evidence": {"provider_errors": []}}, {"key": "source_resolution", "status": "pending", "reason": null, "evidence": null}, {"key": "protocol_reconstruction", "status": "pending", "reason": null, "evidence": null}, {"key": "control_execution", "status": "pending", "reason": null, "evidence": null}, {"key": "control_comparison", "status": "pending", "reason": null, "evidence": null}, {"key": "publication", "status": "pending", "reason": null, "evidence": null}], "gaps": ["review.human_critique", "review.machine_critique.passed"]}, "execution": {"state": "absent", "status": "not_run", "mode": null, "runs": [], "gaps": ["execution.not_run"]}, "provenance": {"entities": [{"id": "package:7b08e8e16e2d1051f325081abca3a53fec0dff0838350ad3f04b8761f04e3821", "type": "sep_package", "label": "SEP v1 package for pmid:34248362"}], "activities": [{"id": "activity:conversion:pmid:34248362", "type": "conversion", "used": ["package:7b08e8e16e2d1051f325081abca3a53fec0dff0838350ad3f04b8761f04e3821"], "agent": "agent:corpus-assay-engine"}], "agents": [{"id": "agent:minimax-m3", "type": "model", "label": "minimax-m3"}, {"id": "agent:minimax-m3-1-flash", "type": "model", "label": "minimax-m3-1-flash"}, {"id": "agent:corpus-assay-engine", "type": "software", "label": "Corpus assay engine"}], "source_run_id": "run-20261023T122449232913", "dsl_catalogue_fingerprint": "343fb30756ba6ec3", "capability_table_fingerprint": "2cb3e42f047d2ecf", "snapshot_id": "ba34b49490d9bfaf"}, "lineage": {"parent_id": "pmid:34248362", "parent_hash": "sha256:4d38fd2f33287ea1d7f6070b05ce902811ad5ab84633a9d5d8bce674adafe941", "fork_of": null, "generation": 2}, "gaps": ["abstract", "asset:materials:the analysis programme that recomputes the published estimate not verified", "asset:materials:the source data behind the published result in pmid:34248362 not verified", "asset:source:pmid:34248362 not verified", "authors", "capability:capability:bench_workcell purchasable", "data:accession_absent", "execution.not_run", "review.human_critique", "review.machine_critique.passed", "step:obtain_source_data blocked on data:accession_absent", "step:provide_capability_bench_workcell blocked on instrument not yet purchased", "step:run_analysis blocked on method:epidemiological_modelling_incidence_rate"]}