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pmid:34249899
Development and Validation of a Robust Ferroptosis-Related Prognostic Signature in Lung Adenocarcinoma.
Anran Zhang · Jinpo Yang · Chao Ma · Feng Li · Huan Luo
Frontiers in cell and developmental biology · 2021 doi:10.3389/fcell.2021.616271
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Complete file
{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:34249899", "kind": "science-record", "revision": 7, "content_hash": "sha256:da8bf430890ab638d3133deb11fd3df62e4d994e581e6065a72672ec64ee8d03", "created_at": "2026-11-01T15:41:42Z", "updated_at": "2026-11-01T22:04:10Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Development and Validation of a Robust Ferroptosis-Related Prognostic Signature in Lung Adenocarcinoma.", "doi": "10.3389/fcell.2021.616271", "pmid": "34249899", "authors": ["Anran Zhang", "Jinpo Yang", "Chao Ma", "Feng Li", "Huan Luo"], "journal": "Frontiers in cell and developmental biology", "year": 2021, "abstract": "BACKGROUND: Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer. Ferroptosis is a newly recognized process of cell death, which is different from other forms of cell death in morphology, biochemistry, and genetics, and has played a vital role in cancer biology. This study aimed to identify a ferroptosis-related gene signature associated with LUAD prognosis.\nMETHODS: Dataset TCGA-LUAD which came from the TCGA portal was taken as the training cohort. GSE72094 and GSE68465 from the GEO database were treated as validation cohorts. Two hundred fifty-nine ferroptosis-related genes were retrieved from the FerrDb database. In the training cohort, Kaplan-Meier and univariate Cox analyses were conducted for preliminary screening of ferroptosis-related genes with potential prognostic capacity. These genes then entered into the LASSO Cox regression model, constructing a gene signature. The latter was then evaluated in the training and validation cohorts via Kaplan-Meier, Cox, and ROC analyses. In addition, the correlations between risk score and autophagy were examined by Pearson correlation coefficient. The analyses of GSEA and immune infiltrating were performed for better studying the function annotation of the gene signature and the character of each kind of immune cells played in the tumor microenvironment.\nRESULTS: A 15-gene signature was found from the training cohort and validated by Kaplan-Meier and Cox regression analyses, revealing its independent prognosis value in LUAD. Moreover, the ROC analysis was conducted, confirming a strong predictive ability that this signature owned for LUAD prognosis. One hundred fifty-one of 222 (68.01%) autophagy-related genes were discovered significantly correlated with risk scores. Analyses of GSEA and immune infiltration exhibited in detail the specific pathways that associate with the 15-gene signature and identified the crucial roles of resting mast cells and resting dendritic cells owned in the prognosis of the 15-gene signature.\nCONCLUSION: In this present study, a novel ferroptosis-related 15-gene signature (RELA, ACSL3, YWHAE, EIF2S1, CISD1, DDIT4, RRM2, PANX1, TLR4, ARNTL, LPIN1, HERPUD1, NCOA4, PEBP1, and GLS2) was built. It could accurately predict the prognosis of LUAD and was related to resting mast cells and resting dendritic cells, which provide potential for the personalized outcome prediction and the development of new therapies in LUAD population.", "claims": [{"id": "claim-method", "statement": "The Pearson correlation coefficient was applied to assess the correlation between autophagy and gene signature risk score.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:34249899", "locator": "sections[6] \"Relationships Between Gene Signature and Autophagy in LUAD\" paragraph 2", "quote": "The Pearson correlation coefficient was applied to assess the correlation between autophagy and gene signature risk score."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The datasets presented in this study can be found in online repositories. The names of the repository/repositories and accession number (s) can be found below: https://portal.gdc.cancer.gov/, TCGA-LUAD; https://www.ncbi.nlm.nih.gov/geo/, GSE72094; https://www.ncbi.nlm.nih.gov/geo/, GSE68465.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:34249899", "locator": "sections[19] \"Data Availability Statement\" paragraph 2", "quote": "The datasets presented in this study can be found in online repositories. The names of the repository/repositories and accession number (s) can be found below: https://portal.gdc.cancer.gov/, TCGA-LUAD; https://www.ncbi.nlm.nih.gov/geo/, GSE72094; https://www.ncbi.nlm.nih.gov/geo/, GSE68465."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": null, "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:34249899"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. This lane did not download the dataset or read its licence.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE68465"], "outputs": ["the source data with its repository provenance"], "instruments": [], "reagents": []}, {"id": "run_analysis", "order": 3, "name": "Run the published analysis", "kind": "analysis", "state": "complete", "blocked_on": null, "description": "Apply the paper's statistical method to the resolved series and compare the result with the published target.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE68465"], "outputs": ["the replicated result and its comparison"], "instruments": [], "reagents": []}], "materials": [], "instruments": [], "reagents": [], "conditions": {}, "gaps": []}, "data": {"state": "partial", "assets": [{"id": "source:pmid:34249899", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.3389/fcell.2021.616271", "sha256": "sha256:e3045e2d12dc0daa7419ba8305a4864321ae7210ff4b7d24a4700762a5c17d8a", "bytes": 45181, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "10.3389/fcell.2021.616271", "version": null, "note": "Full article fetched from PMC; the checksum covers the rendered section body, not the original XML bytes.", "structure": {"pmcid": "PMC8264775", "source": "europe_pmc_fulltext", "coverage": "whole_body_without_references", "text_hash_scope": "rendered_section_body"}}, {"id": "data:geo:GSE68465", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE68465", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE68465", "version": null, "note": "The datasets presented in this study can be found in online repositories. 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(16%)", "63 (14.25%)", "NA"], ["", "Stage IV", "25 (5%)", "17 (3.85%)", "NA"], ["", "Unknown", "8 (1.6%)", "28 (6.33%)", "NA"], ["Race", "", "", ""], ["", "White", "386 (77.2%)", "399 (90.27%)", "295 (66.59%)"], ["", "Black or African American", "52 (10.4%)", "13 (2.94%)", "12 (2.71%)"], ["", "American Indian or Alaska native", "1 (0.2%)", "0", "1 (0.23%)"], ["", "Asian", "7 (1.4%)", "3 (0.68%)", "6 (1.35%)"], ["", "Unknown", "54 (10.8%)", "27 (6.11%)", "129 (29.12%)"], ["Ethnicity", "", "", ""], ["", "Hispanic or Latino", "7 (1.4%)", "10 (2.26%)", "NA"], ["", "Not Hispanic or Latino", "381 (76.2%)", "402 (90.95%)", "NA"], ["", "Unknown", "112 (22.4%)", "30 (6.79%)", "NA"], ["Tobacco smoking history", "", "", ""], ["", "Ever", "415 (83%)", "335 (75.79%)", "300 (67.72%)"], ["", "Never", "71 (14.2%)", "33 (7.47%)", "49 (11.06%)"], ["", "Unknown", "14 (2.8%)", "74 (16.74%)", "94 (21.22%)"], ["Number pack years smoked", "", "", ""], ["", "< 30", "115 (23%)", "NA", "NA"], ["", "> = 30", "227 (45.4%)", "NA", "NA"], ["", "Unknown", "158 (31.6%)", "NA", "NA"], ["Radiation therapy", "", "", ""], ["", "Yes", "58 (11.6%)", "NA", "65 (14.67%)"], ["", "No", "361 (72.2%)", "NA", "364 (82.17%)"], ["", "Unknown", "81 (16.2%)", "NA", "14 (3.16%)"], ["Chemotherapy", "", "", ""], ["", "Yes", "NA", "NA", "89 (20.09%)"], ["", "No", "NA", "NA", "341 (76.98%)"], ["", "Unknown", "NA", "NA", "13 (2.93%)"], ["Additional pharmaceutical therapy", "", "", ""], ["", "Yes", "61 (12.2%)", "NA", "NA"], ["", "No", "68 (13.6%)", "NA", "NA"], ["", "Unknown", "371 (74.2%)", "NA", "NA"], ["Additional radiation therapy", "", "", ""], ["", "Yes", "61 (12.2%)", "NA", "NA"], ["", "No", "71 (14.2%)", "NA", "NA"], ["", "Unknown", "368 (73.6%)", "NA", "NA"], ["EGFR mutation", "", "", ""], ["", "Yes", "80 (16%)", "47 (10.63%)", "NA"], ["", "No", "191 (38.2%)", "395 (89.37%)", "NA"], ["", "Unknown", "229 (45.8%)", "0", "NA"], ["KRAS mutation", "", "", ""], ["", "Yes", "23 (4.6%)", "154 (34.84%)", "NA"], ["", "No", "39 (7.8%)", "288 (65.16%)", "NA"], ["", "Unknown", "438 (87.6%)", "0", "NA"], ["STK11 mutation", "", "", ""], ["", "Yes", "NA", "68 (15.38%)", "NA"], ["", "No", "NA", "374 (84.62%)", "NA"], ["TP53 mutation", "", "", ""], ["", "Yes", "NA", "111 (25.11%)", "NA"], ["", "No", "NA", "331 (74.89%)", "NA"], ["EML4-ALK mutation", "", "", ""], ["", "Yes", "34 (6.8%)", "NA", "NA"], ["", "No", "207 (41.4%)", "NA", "NA"], ["", "Unknown", "259 (51.8%)", "NA", "NA"], ["Tumor intermediate dimension", "", "", ""], ["", "< 1", "287 (57.4%)", "NA", "NA"], ["", "> = 1", "88 (17.6%)", "NA", "NA"], ["", "Unknown", "125 (25%)", "NA", "NA"], ["Location in lung parenchyma", "", "", ""], ["", "Central lung", "62 (12.4%)", "NA", "NA"], ["", "Peripheral lung", "118 (23.6%)", "NA", "NA"], ["", "Unknown", "320 (64%)", "NA", "NA"], ["Person neoplasm cancer status", "", "", ""], ["", "With tumor", "134 (26.8%)", "NA", "NA"], ["", "Tumor free", "243 (48.6%)", "NA", "NA"], ["", "Unknown", "123 (24.6%)", "NA", "NA"], ["Vital status", "", "", ""], ["", "Alive", "318 (63.6%)", "298 (67.42%)", "207 (46.73%)"], ["", "Dead", "182 (36.4%)", "122 (27.6%)", "236 (53.27%)"], ["", "Unknown", "0", "22 (4.98%)", "0"]], "row_count": 98, "column_count": 5, "numeric_cells": 144, "header_rows": 1, "locator": "section[11]/table-wrap[1]#T1"}}, {"id": "asset:table:pmid:34249899:2", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:275659e4526a218f81e72aa38cd162058f34738dcab6acb55abc69a4881caeb9", "bytes": 3555, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[12]/table-wrap[1]#T2", "version": null, "note": "Twenty-nine ferroptosis-related potential prognostic genes generated from the training cohort.", "structure": {"pmcid": "PMC8264775", "section_index": 12, "section_title": "Identification of Prognostic Ferroptosis-Related Gene Signature From the Training Cohort", "row_count": 31, "column_count": 8}, "table": {"label": "TABLE 2", "caption": "Twenty-nine ferroptosis-related potential prognostic genes generated from the training cohort.", "rows": [["Gene symbol", "Description", "Category", "Kaplan–Meier analysis (P-value)", "Univariate Cox regression analysis"], ["", "", "", "", "HR", "HR_95L", "HR_95H", "P-value"], ["ACSL3", "Acyl-CoA synthetase long-chain family member 3", "Protein coding", "1.82E-02", "1.435", "1.157", "1.780", "1.00E-03"], ["ARNTL", "Aryl hydrocarbon receptor nuclear translocator like", "Protein coding", "1.14E-02", "0.676", "0.492", "0.929", "1.59E-02"], ["AURKA", "Aurora kinase A", "Protein coding", "1.97E-02", "1.268", "1.103", "1.458", "8.61E-04"], ["BACH1", "BTB domain and CNC homolog 1", "Protein coding", "9.67E-03", "1.310", "1.012", "1.696", "4.05E-02"], ["CDO1", "Cysteine dioxygenase type 1", "Protein coding", "4.11E-02", "0.713", "0.522", "0.973", "3.30E-02"], ["CISD1", "CDGSH iron sulfur domain 1", "Protein coding", "2.41E-03", "1.403", "1.041", "1.891", "2.59E-02"], ["CISD2", "CDGSH iron sulfur domain 2", "Protein coding", "1.98E-03", "1.372", "1.005", "1.872", "4.64E-02"], ["DDIT4", "DNA damage inducible transcript 4", "Protein coding", "8.47E-03", "1.214", "1.072", "1.374", "2.22E-03"], ["EIF2S1", "Eukaryotic translation initiation factor 2 subunit alpha", "Protein coding", "6.52E-03", "1.655", "1.219", "2.248", "1.24E-03"], ["FANCD2", "FA complementation group D2", "Protein coding", "4.87E-03", "1.428", "1.095", "1.861", "8.48E-03"], ["FLT3", "Fms-related receptor tyrosine kinase 3", "Protein coding", "2.24E-02", "0.452", "0.247", "0.829", "1.02E-02"], ["GLS2", "Glutaminase 2", "Protein coding", "5.27E-03", "0.356", "0.177", "0.718", "3.91E-03"], ["HELLS", "Helicase, lymphoid specific", "Protein coding", "3.45E-03", "1.282", "1.025", "1.604", "2.96E-02"], ["HERPUD1", "Homocysteine-inducible ER protein with ubiquitin-like domain 1", "Protein coding", "8.21E-05", "0.656", "0.523", "0.823", "2.67E-04"], ["IL33", "Interleukin 33", "Protein coding", "3.77E-02", "0.841", "0.740", "0.956", "8.11E-03"], ["KLHL24", "Kelch-like family member 24", "Protein coding", "4.06E-02", "0.761", "0.580", "0.998", "4.81E-02"], ["LINC00336", "Long intergenic non-protein-coding RNA 336", "RNA Gene", "2.25E-02", "0.339", "0.120", "0.952", "4.01E-02"], ["LPIN1", "Lipin 1", "Protein coding", "4.63E-02", "0.788", "0.623", "0.997", "4.67E-02"], ["NCOA4", "Nuclear receptor coactivator 4", "Protein coding", "1.33E-02", "0.776", "0.603", "0.999", "4.89E-02"], ["NRAS", "NRAS proto-oncogene, GTPase", "Protein coding", "3.23E-02", "1.360", "1.077", "1.717", "9.68E-03"], ["PANX1", "Pannexin 1", "Protein coding", "3.25E-04", "1.489", "1.147", "1.932", "2.75E-03"], ["PEBP1", "Phosphatidylethanolamine-binding protein 1", "Protein coding", "6.95E-04", "0.604", "0.465", "0.784", "1.53E-04"], ["RELA", "RELA proto-oncogene, NF-KB subunit", "Protein coding", "4.45E-02", "1.745", "1.129", "2.698", "1.23E-02"], ["RRM2", "Ribonucleotide reductase regulatory subunit M2", "Protein coding", "5.69E-04", "1.323", "1.164", "1.503", "1.73E-05"], ["SLC2A1", "Solute carrier family 2 member 1", "Protein coding", "4.18E-05", "1.261", "1.134", "1.401", "1.71E-05"], ["SLC3A2", "Solute carrier family 3 member 2", "Protein coding", "2.93E-02", "1.345", "1.067", "1.695", "1.21E-02"], ["TLR4", "Toll-like receptor 4", "Protein coding", "4.18E-02", "0.834", "0.699", "0.996", "4.47E-02"], ["VDAC2", "Voltage-dependent anion channel 2", "Protein coding", "7.90E-03", "1.592", "1.213", "2.090", "7.99E-04"], ["YWHAE", "Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation Protein Epsilon", "Protein coding", "4.52E-02", "1.435", "1.046", "1.969", "2.51E-02"]], "row_count": 31, "column_count": 8, "numeric_cells": 172, "header_rows": 2, "locator": "section[12]/table-wrap[1]#T2"}}, {"id": "asset:table:pmid:34249899:3", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:530d4cbb49ca68673a61b68eeb684ea5c5fa003413835f2289fd4a65b2e9d558", "bytes": 1603, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[12]/table-wrap[2]#T3", "version": null, "note": "Fifteen ferroptosis-related prognostic genes obtained from LASSO Cox regression model.", "structure": {"pmcid": "PMC8264775", "section_index": 12, "section_title": "Identification of Prognostic Ferroptosis-Related Gene Signature From the Training Cohort", "row_count": 16, "column_count": 4}, "table": {"label": "TABLE 3", "caption": "Fifteen ferroptosis-related prognostic genes obtained from LASSO Cox regression model.", "rows": [["Gene symbol", "Description", "Annotation*", "Risk coefficient"], ["ACSL3", "Acyl-CoA synthetase long-chain family member 3", "Ferroptosis suppressor", "0.292079905"], ["ARNTL", "Aryl hydrocarbon receptor nuclear translocator-like", "Ferroptosis suppressor", "−0.052913519"], ["CISD1", "CDGSH iron sulfur domain 1", "Ferroptosis suppressor", "0.156274215"], ["DDIT4", "DNA damage-inducible transcript 4", "Ferroptosis marker", "0.079830296"], ["EIF2S1", "Eukaryotic translation initiation factor 2 subunit alpha", "Ferroptosis marker", "0.159470859"], ["GLS2", "Glutaminase 2", "Ferroptosis driver", "−0.267566406"], ["HERPUD1", "Homocysteine-inducible ER protein with ubiquitin-like domain 1", "Ferroptosis marker", "−0.213560347"], ["LPIN1", "Lipin 1", "Ferroptosis driver", "−0.179354454"], ["NCOA4", "Nuclear receptor coactivator 4", "Ferroptosis driver", "−0.253508649"], ["PANX1", "Pannexin 1", "Ferroptosis driver", "0.013029525"], ["PEBP1", "Phosphatidylethanolamine-binding protein 1", "Ferroptosis driver", "−0.262091825"], ["RELA", "RELA proto-oncogene, NF-KB subunit", "Ferroptosis marker", "0.31121564"], ["RRM2", "Ribonucleotide reductase regulatory subunit M2", "Ferroptosis marker", "0.043449128"], ["TLR4", "Toll-like receptor 4", "Ferroptosis driver", "−0.010188709"], ["YWHAE", "Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon", "Ferroptosis marker", "0.160823922"]], "row_count": 16, "column_count": 4, "numeric_cells": 27, "header_rows": 1, "locator": "section[12]/table-wrap[2]#T3"}}, {"id": "asset:table:pmid:34249899:4", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:09bb689a4ef091c9fb36eb51e878bd3edc16dc188a06fb9ee9789385c223da4a", "bytes": 7541, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[13]/table-wrap[1]#T4", "version": null, "note": "Univariate analysis and multivariate analysis of the correlation of gene-signature risk score with outcomes among lung adenocarcinoma patients in three cohorts*.", "structure": {"pmcid": "PMC8264775", "section_index": 13, "section_title": "Prognostic Value of the 15-Gene Signature in the Training and Validation Cohorts", "row_count": 67, "column_count": 9}, "table": {"label": "TABLE 4", "caption": "Univariate analysis and multivariate analysis of the correlation of gene-signature risk score with outcomes among lung adenocarcinoma patients in three cohorts*.", "rows": [["Variable", "Univariate Cox analysis", "Multivariate Cox analysis"], ["", "coef", "HR (95% CI)", "z", "P-value", "coef", "HR (95% CI)", "z", "P-value"], ["TCGA-LUAD (overall survival)^", "", "", "", "", "", "", "", ""], ["Gender (male vs. female)", "0.048", "1.05 (0.784–1.4)", "0.322", "7.47E-01", "", "", "", ""], ["Age", "0.00816", "1.01 (0.993–1.02)", "1.05", "2.94E-01", "", "", "", ""], ["Tumor stage II (vs. stage I)", "0.905", "2.47 (1.72–3.56)", "4.87", "1.09E-06", "1.49", "4.43 (1.69–11.6)", "3.02", "2.49E-03"], ["Tumor stage III (vs. stage I)", "1.25", "3.49 (2.38–5.12)", "6.4", "1.51E-10", "0.705", "2.02 (0.613–6.68)", "1.16", "2.48E-01"], ["Tumor stage IV (vs. stage I)", "1.34", "3.82 (2.2–6.62)", "4.76", "1.92E-06", "-0.125", "0.882 (0.248–3.14)", "–0.193", "8.47E-01"], ["Tobacco smoking history (ever vs. never)", "–0.127", "0.88 (0.583–1.33)", "–0.605", "5.45E-01", "", "", "", ""], ["Number pack years smoked", "0.00327", "1 (0.996–1.01)", "0.938", "3.48E-01", "", "", "", ""], ["Race (white vs. non-white)", "0.36", "1.43 (0.875–2.34)", "1.43", "1.53E-01", "", "", "", ""], ["Ethnicity (Hispanic or Latino vs. non-Hispanic or Latino)", "0.387", "1.47 (0.466–4.65)", "0.658", "5.10E-01", "", "", "", ""], ["Tumor intermediate dimension", "0.441", "1.55 (0.922–2.62)", "1.65", "9.80E-02", "", "", "", ""], ["Radiation therapy (yes vs. no)", "0.763", "2.14 (1.44–3.19)", "3.76", "1.73E-04", "0.397", "1.49 (0.451–4.9)", "0.653", "5.14E-01"], ["Additional pharmaceutical therapy (yes vs. no)", "–0.502", "0.605 (0.382–0.959)", "–2.14", "3.26E-02", "-0.567", "0.567 (0.263–1.22)", "–1.45", "1.48E-01"], ["Additional radiation therapy (yes vs. no)", "–0.0153", "0.985 (0.625–1.55)", "–0.0661", "9.47E-01", "", "", "", ""], ["Location in lung parenchyma (central lung vs. peripheral lung)", "0.0908", "1.09 (0.684–1.75)", "0.378", "7.06E-01", "", "", "", ""], ["KRAS mutation (yes vs. no)", "0.492", "1.63 (0.672–3.98)", "1.08", "2.78E-01", "", "", "", ""], ["EGFR mutation (yes vs. no)", "0.268", "1.31 (0.828–2.06)", "1.15", "2.50E-01", "", "", "", ""], ["EML4-ALK mutation (yes vs. no)", "0.592", "1.81 (1.01–3.24)", "1.98", "4.73E-02", "1.52", "4.55 (1.62–12.8)", "2.88", "3.98E-03"], ["Risk score", "1.33", "3.77 (2.77–5.14)", "8.4", "4.59E-17", "1.87", "6.52 (2.74–15.5)", "4.24", "2.20E-05"], ["TCGA-LUAD (progression-free survival) #", "", "", "", "", "", "", "", ""], ["Gender (male vs. female)", "0.07", "1.07 (0.815–1.41)", "0.499", "6.17E-01", "", "", "", ""], ["Age", "–0.000998", "0.999 (0.985–1.01)", "–0.141", "8.88E-01", "", "", "", ""], ["Tumor stage II (vs. stage I)", "0.798", "2.22 (1.61–3.07)", "4.85", "1.22E-06", "1.18", "3.26 (1.88–5.66)", "4.22", "2.44E-05"], ["Tumor stage III (vs. stage I)", "0.709", "2.03 (1.38–2.99)", "3.61", "3.10E-04", "0.866", "2.38 (1.2–4.69)", "2.49", "1.26E-02"], ["Tumor stage IV (vs. stage I)", "0.849", "2.34 (1.32–4.13)", "2.93", "3.40E-03", "0.697", "2.01 (0.846–4.77)", "1.58", "1.14E-01"], ["Tobacco smoking history (ever vs. never)", "–0.0557", "0.946 (0.637–1.4)", "–0.276", "7.82E-01", "", "", "", ""], ["Number pack years smoked", "–0.000552", "0.999 (0.993–1.01)", "–0.165", "8.69E-01", "", "", "", ""], ["Race (white vs. non-white)", "0.0557", "1.06 (0.703–1.59)", "0.268", "7.89E-01", "", "", "", ""], ["Ethnicity (Hispanic or Latino vs. non-Hispanic or Latino)", "0.291", "1.34 (0.495–3.62)", "0.574", "5.66E-01", "", "", "", ""], ["Tumor intermediate dimension", "0.328", "1.39 (0.84–2.29)", "1.28", "2.01E-01", "", "", "", ""], ["Radiation therapy (yes vs. no)", "0.707", "2.03 (1.42–2.89)", "3.92", "9.01E-05", "0.43", "1.54 (0.827–2.86)", "1.36", "1.74E-01"], ["Additional pharmaceutical therapy (yes vs. no)", "0.27", "1.31 (0.914–1.88)", "1.47", "1.41E-01", "", "", "", ""], ["Additional radiation therapy (yes vs. no)", "0.16", "1.17 (0.825–1.67)", "0.89", "3.73E-01", "", "", "", ""], ["Location in lung parenchyma (central lung vs. peripheral lung)", "–0.0709", "0.932 (0.584–1.49)", "–0.298", "7.66E-01", "", "", "", ""], ["KRAS mutation (yes vs. no)", "–0.275", "0.759 (0.316–1.82)", "–0.616", "5.38E-01", "", "", "", ""], ["EGFR mutation (yes vs. no)", "0.483", "1.62 (1.06–2.49)", "2.21", "2.71E-02", "0.319", "1.38 (0.846–2.24)", "1.29", "1.98E-01"], ["EML4-ALK mutation (yes vs. no)", "0.509", "1.66 (0.965–2.87)", "1.83", "6.72E-02", "", "", "", ""], ["Risk score", "0.83", "2.29 (1.72–3.06)", "5.63", "1.79E-08", "0.756", "2.13 (1.3–3.5)", "2.98", "2.84E-03"], ["GSE72094 (overall survival) &", "", "", "", "", "", "", "", ""], ["Gender (male vs. female)", "0.44", "1.55 (1.07–2.25)", "2.33", "1.98E-02", "0.444", "1.56 (1.07–2.28)", "2.29", "2.20E-02"], ["Age", "0.00696", "1.01 (0.988–1.03)", "0.702", "4.83E-01", "", "", "", ""], ["Race (white vs. non-white)", "–0.0694", "0.933 (0.38–2.29)", "–0.151", "8.80E-01", "", "", "", ""], ["Ethnicity (Hispanic or Latino vs. non-Hispanic or Latino)", "–0.642", "0.526 (0.0733–3.78)", "–0.638", "5.24E-01", "", "", "", ""], ["Tobacco smoking history (ever vs. never)", "0.314", "1.37 (0.597–3.14)", "0.741", "4.59E-01", "", "", "", ""], ["Tumor stage II (vs. stage I)", "0.758", "2.13 (1.32–3.44)", "3.11", "1.85E-03", "0.69", "1.99 (1.23–3.23)", "2.81", "4.92E-03"], ["Tumor stage III (vs. stage I)", "1.13", "3.09 (1.93–4.97)", "4.67", "3.00E-06", "1.15", "3.14 (1.95–5.07)", "4.69", "2.79E-06"], ["Tumor stage IV (vs. stage I)", "1.21", "3.35 (1.59–7.06)", "3.18", "1.48E-03", "1.22", "3.39 (1.6–7.15)", "3.2", "1.37E-03"], ["KRAS mutation (yes vs. no)", "0.376", "1.46 (1–2.12)", "1.97", "4.92E-02", "0.13", "1.14 (0.774–1.68)", "0.66", "5.09E-01"], ["EGFR mutation (yes vs. no)", "–1.34", "0.262 (0.0965–0.71)", "–2.63", "8.49E-03", "-0.822", "0.44 (0.158–1.22)", "–1.57", "1.16E-01"], ["STK11 mutation (yes vs. no)", "–0.0393", "0.961 (0.58–1.59)", "–0.153", "8.79E-01", "", "", "", ""], ["TP53 mutation (yes vs. no)", "0.211", "1.23 (0.82–1.86)", "1.01", "3.13E-01", "", "", "", ""], ["Risk score", "0.855", "2.35 (1.76–3.14)", "5.77", "8.07E-09", "0.734", "2.08 (1.53–2.84)", "4.64", "3.50E-06"], ["GSE68465 (overall survival) $", "", "", "", "", "", "", "", ""], ["Gender (male vs. female)", "0.33", "1.39 (1.07–1.8)", "2.5", "1.25E-02", "0.271", "1.31 (0.991–1.74)", "1.9", "5.78E-02"], ["Age", "0.0266", "1.03 (1.01–1.04)", "3.97", "7.16E-05", "0.035", "1.04 (1.02–1.05)", "4.84", "1.28E-06"], ["Race (white vs. non-white)", "0.32", "1.38 (0.702–2.71)", "0.931", "3.52E-01", "", "", "", ""], ["Chemotherapy (yes vs. no)", "0.488", "1.63 (1.22–2.18)", "3.29", "9.99E-04", "0.222", "1.25 (0.84–1.86)", "1.1", "2.72E-01"], ["Radiation therapy (yes vs. no)", "0.698", "2.01 (1.47–2.75)", "4.37", "1.26E-05", "0.274", "1.31 (0.848–2.04)", "1.22", "2.21E-01"], ["T classification (T2 vs. T1)", "0.381", "1.46 (1.09–1.97)", "2.52", "1.18E-02", "0.145", "1.16 (0.846–1.58)", "0.912", "3.62E-01"], ["T classification (T3 vs. T1)", "1.2", "3.31 (2.06–5.34)", "4.92", "8.78E-07", "0.758", "2.13 (1.29–3.53)", "2.95", "3.22E-03"], ["T classification (T4 vs. T1)", "1.45", "4.26 (2.17–8.34)", "4.22", "2.41E-05", "1.04", "2.82 (1.33–5.98)", "2.7", "6.92E-03"], ["N classification (N1 vs. N0)", "0.821", "2.27 (1.67–3.09)", "5.23", "1.74E-07", "0.773", "2.17 (1.57–3)", "4.67", "3.02E-06"], ["N classification (N2 vs. N0)", "1.36", "3.9 (2.77–5.48)", "7.82", "5.47E-15", "1.23", "3.41 (2.31–5.02)", "6.19", "5.97E-10"], ["Tobacco smoking history (ever vs. never)", "0.22", "1.25 (0.79–1.96)", "0.946", "3.44E-01", "", "", "", ""], ["Risk score", "0.452", "1.57 (1.29–1.92)", "4.43", "9.27E-06", "0.44", "1.55 (1.24–1.94)", "3.88", "1.04E-04"]], "row_count": 67, "column_count": 9, "numeric_cells": 370, "header_rows": 2, "locator": "section[13]/table-wrap[1]#T4"}}], "gaps": ["asset:data:geo:GSE68465 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