Dyslipidemia in Chinese Pancreatic Cancer Patients: A Two-Center Retrospective Study.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:34335950", "kind": "science-record", "revision": 9, "content_hash": "sha256:9901a7cdc23a692a68695a55a85ec6d3d8f34f48a90711358cf96a9a396b24c5", "created_at": "2026-11-01T15:41:46Z", "updated_at": "2026-11-01T22:47:14Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Dyslipidemia in Chinese Pancreatic Cancer Patients: A Two-Center Retrospective Study.", "doi": "10.7150/jca.60340", "pmid": "34335950", "authors": ["Feiyang Wang", "Li Huang", "Jinyan Zhang", "Junwei Fan", "Heshui Wu", "Junming Xu"], "journal": "Journal of Cancer", "year": 2021, "abstract": "Background: Pancreatic cancer (PC) is one of the most aggressive and lethal malignancies in the world. High cholesterol intake may have a certain association with an elevated risk of PC, though dyslipidemia in PC patients has rarely been reported. In this study, we compared serum lipids levels between PC and non-PC tumor patients and assessed their prognostic value in PC. Methods: 271 patients treated at Wuhan Union Hospital from January 2012 to December 2016 and 204 individuals at Shanghai General Hospital from January 2018 to December 2019 were recruited. Their demographic parameters, laboratory data, pathological information, and clinical outcomes were extracted and analyzed. The mRNA expressions of related lipoprotein, low density lipoprotein receptor (LDLR) and high density lipoprotein binding protein (HDLBP), in PC tissues and paired noncancerous tissues and follow-up information were assessed based on the GEO database (GSE15471 and GSE62165) and TCGA database. Results: A total of 172 non-PC tumor patients and 260 PC patients were finally eligible for our analysis. PC patients exhibited higher levels of serum triglyceride, cholesterol, and low-density lipoprotein (LDL) and a lower serum high-density lipoprotein (HDL) level on admission versus the non-PC tumor group. In PC patients, LDLR mRNA expression was upregulated, and HDLBP mRNA expression was downregulated in cancerous tissues compared to these levels in paired noncancerous tissues. The survival analysis revealed that dyslipidemia had a non-significant association with a poor prognosis, but PC patients with a high LDLR level were at risk of poor survival. Conclusion: Dyslipidemia is detected in PC patients but has a non-significant relation to PC prognosis. However, LDLR may be a potential predictive marker for PC prognosis.", "claims": [{"id": "claim-data-access", "statement": "The mRNA expression data of GSE15471 (39 matched pairs of samples) and GSE62165 (118 PC tissue samples and 13 paracancerous tissue samples) were acquired to identify differential target genes of related lipoprotein in PC.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:34335950", "locator": "sections[4] \"Microarray data collection\" paragraph 2", "quote": "The mRNA expression data of GSE15471 (39 matched pairs of samples) and GSE62165 (118 PC tissue samples and 13 paracancerous tissue samples) were acquired to identify differential target genes of related lipoprotein in PC."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "partial", "objective": null, "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:34335950"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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(1.39, 5.97)", "0.004"], ["Alanine aminotransferase, >50 U/L", "6.58 (4.21, 10.29)", "<0.001", "3.46 (1.55, 7.69)", "0.002"], ["Albumin, <35 g/L", "1.27 (0.72, 2.24)", "0.417", "", ""], ["Serum glucose, >7.0 mmol/L", "2.45 (1.47, 4.08)", "0.001", "", ""], ["Activated partial thromboplastin time, >40 s", "1.21 (0.68, 2.14)", "0.521", "", ""], ["CA199, >25 U/ml", "18.78 (11.30, 31.22)", "<0.001", "10.87 (5.97, 19.80)", "<0.001"], ["Triglyceride, >1.7 mmol/L", "1.82 (1.18, 2.81)", "0.007", "", ""], ["Cholesterol, >5.18 mmol/L", "2.10 (1.28, 3.45)", "0.003", "", ""], ["High density lipoprotein, <1.16 mmol/L", "1.74 (1.13, 2.67)", "0.012", "", ""], ["Low density lipoprotein, >4.14 mmol/L", "3.10 (1.25, 7.69)", "0.015", "", ""]], "row_count": 16, "column_count": 5, "numeric_cells": 48, "header_rows": 2, "locator": "section[8]/table-wrap[1]#T2"}}, {"id": "asset:table:pmid:34335950:3", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:0ac533140f049f2821bbbbd4801d84573696f107654d3a6e94d8170e154952df", "bytes": 2681, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[9]/table-wrap[1]#T3", "version": null, "note": "Clinicopathological and follow-up information of PC patients in different lipid level", "structure": {"pmcid": "PMC8317532", "section_index": 9, "section_title": "Clinicopathological features and survival analysis between PC patients with different lipid levels", "row_count": 21, "column_count": 13}, "table": {"label": "Table 3", "caption": "Clinicopathological and follow-up information of PC patients in different lipid level", "rows": [["", "High CHOL", "Low CHOL", "P value", "High TG", "Low TG", "P value", "Low HDL", "High HDL", "P value", "High LDL", "Low LDL", "P value"], ["Tumor size, cm", "73", "164", "<0.001", "96", "141", "0.057", "158", "69", "0.869", "27", "201", "<0.001"], ["", "2.91±1.04", "3.63±1.48", "", "3.20±1.24", "3.55±1.47", "", "3.37±1.41", "3.40±1.38", "", "3.50±1.40", "2.55±1.00", ""], ["Operation type", "73", "169", "0.143", "97", "145", "0.102", "162", "69", "0.124", "27", "202", "0.218"], ["Radical resection", "71 (97.3%)", "156 (92.3%)", "", "94 (96.9%)", "133 (91.7%)", "", "152 (93.8%)", "68 (98.6%)", "", "27 (100.0%)", "191 (94.6%)", ""], ["Palliative resection", "2 (2.7%)", "13 (7.7%)", "", "3 (3.1%)", "12 (8.3%)", "", "10 (6.2%)", "1 (1.4%)", "", "0 (0.0%)", "11 (5.4%)", ""], ["AJCC stage", "73", "169", "0.055", "97", "145", "0.074", "162", "69", "0.246", "27", "202", "0.961"], ["Stage I, II", "56 (76.7%)", "113 (66.9%)", "", "74 (76.3%)", "95 (65.5%)", "", "118 (72.8%)", "45 (65.2%)", "", "20 (74.1%)", "141 (69.8%)", ""], ["Stage III, IV", "17 (23.3%)", "56 (33.1%)", "", "23 (23.7%)", "50 (34.5%)", "", "44 (27.2%)", "24 (34.8%)", "", "7 (25.9%)", "61 (30.2%)", ""], ["Differentiation degree", "67", "143", "0.601", "86", "128", "0.394", "146", "62", "0.186", "25", "178", 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