DTYMK promote hepatocellular carcinoma proliferation by regulating cell cycle.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:34369850", "kind": "science-record", "revision": 3, "content_hash": "sha256:05963267154c74cdb15715711952472ea014a8cb6ee71a4a0be823946ed24f65", "created_at": "2026-11-01T17:35:55Z", "updated_at": "2026-11-01T21:26:00Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "DTYMK promote hepatocellular carcinoma proliferation by regulating cell cycle.", "doi": "10.1080/15384101.2021.1958502", "pmid": "34369850", "authors": ["Tianhao Zhou", "Rui Qin", "Susu Shi", "Hua Zhang", "Chuanling Niu", "Gaoda Ju", "Sen Miao"], "journal": "Cell cycle (Georgetown, Tex.)", "year": 2021, "abstract": "Overexpression of DTYMK is related with tumorigenesis and progression in several human tumors. However, the role of upregulated DTYMK in hepatocellular carcinoma (HCC) patients still remains unclear. In this study, the DTYMK expression in HCC tumors was evaluated in three GEO series (GSE14520, GSE54236, GSE63898), TCGA-LIHC, and ICGC-IRLR-JP cohorts. Survival analysis of DTYMK based on TCGA-LIHC and ICGC-LIRI-JP cohorts was conducted. We found that DTYMK was dramatically upregulated in tumor tissue compared with that in adjacent liver tissue. Kaplan-Meier analysis revealed that high expression of DTYMK in HCC patients' tumor tissue was significantly corresponded to worse overall survival (OS) (P < 0.05). Further analysis showed that overexpressing DTYMK led to poor relapse free survival (RFS) and disease-specific survival (DSS) (all P < 0.05). In conclusion, DTYMK is upregulated in tumors and correlated with poor prognosis in HCC patients. In our report, DTYMK is higher expression in HCC cancer tissue and cell line than tumor adjacent tissue and normal liver cell line. Knocking down DTYMK can inhabit tumor cell proliferation by interfering cell cycle, whereas overexpression of DTYMK can promote tumor cell proliferation. These findings indicate that upregulation of DTYMK enhances tumor growth and proliferation by promoting cell cycle.", "claims": [{"id": "claim-method", "statement": "Kaplan-Meier analysis revealed that high expression of DTYMK in HCC patients’ tumor tissue was significantly corresponded to worse overall survival (OS) (P < 0.05).", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:34369850", "locator": "sections[0] \"Abstract\" paragraph 1", "quote": "Kaplan-Meier analysis revealed that high expression of DTYMK in HCC patients’ tumor tissue was significantly corresponded to worse overall survival (OS) (P < 0.05)."}], "state": "complete"}, {"id": "claim-data-access", "statement": "In this study, the DTYMK expression in HCC tumors was evaluated in three GEO series (GSE14520, GSE54236, GSE63898), TCGA-LIHC, and ICGC-IRLR-JP cohorts.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:34369850", "locator": "sections[0] \"Abstract\" paragraph 1", "quote": "In this study, the DTYMK expression in HCC tumors was evaluated in three GEO series (GSE14520, GSE54236, GSE63898), TCGA-LIHC, and ICGC-IRLR-JP cohorts."}], "state": "complete"}, {"id": "claim-target-result", "statement": "DTYMK is upregulated in tumors and correlated with poor prognosis in HCC patients.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:34369850", "locator": "sections[0] \"Abstract\" paragraph 1", "quote": "In conclusion, DTYMK is upregulated in tumors and correlated with poor prognosis in HCC patients."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "DTYMK is upregulated in tumors and correlated with poor prognosis in HCC patients.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:34369850"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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