Increased expression of Cyclin F in liver cancer predicts poor prognosis: A study based on TCGA database.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:34397798", "kind": "science-record", "revision": 7, "content_hash": "sha256:44f12d10145fb21114d625c76ea5a78a33ff8d35dfce06ee75ceb30c7d41d854", "created_at": "2026-11-01T15:41:48Z", "updated_at": "2026-11-01T22:04:29Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Increased expression of Cyclin F in liver cancer predicts poor prognosis: A study based on TCGA database.", "doi": "10.1097/MD.0000000000026623", "pmid": "34397798", "authors": ["Yang Zelong", "Yang Han", "Guo Ting", "Wang Yifei", "He Kun", "Hu Haoran", "Chen Yong"], "journal": "Medicine", "year": 2021, "abstract": "BACKGROUND: Cyclin F (CCNF) dysfunction has been implicated in various forms of cancer, offering a new avenue for understanding the pathogenic mechanisms underlying hepatocellular carcinoma (HCC). We aimed to evaluate the role of CCNF in HCC using publicly available data from The Cancer Genome Atlas (TCGA).\nMETHOD: We used TCGA data and Gene Expression Omnibus (GEO) data to analyze the differential expression of CCNF between tumor and adjacent tissues and the relationship between CCNF and clinical characteristics. We compared prognosis of patients with HCC with high and low CCNF expression and constructed receiver operating characteristic (ROC) curves. In addition, we also explored the types of gene mutations in relevant groups and conducted Gene Set Enrichment Analysis (GSEA).\nRESULTS: The expression of CCNF in liver cancer tissues was significantly increased compared with that in adjacent tissues, and patients with high CCNF expression had a worse prognosis than those with low CCNF expression. Patients with high CCNF expression also had more somatic mutations. High expression of CCNF hampers the prognosis independently. The GSEA showed that the \"http://www.gsea-msigdb.org/gsea/msigdb/cards/BIOCARTA_WNT_PATHWAY\" Wnt pathway, \"http://www.gsea-msigdb.org/gsea/msigdb/cards/BIOCARTA_P53_PATHWAY\" P53 pathway, \"http://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_PI3K_AKT_MTOR_SIGNALING\" PI3K/Akt/mTOR pathway, \"http://www.gsea-msigdb.org/gsea/msigdb/cards/HALLMARK_NOTCH_SIGNALING\" Notch pathway were enriched in patients with the high CCNF expression phenotype.\nCONCLUSION: High CCNF expression can be seen as an independent risk factor for poor survival in HCC. Its expression may serve as a target for the diagnosis and treatment of liver cancer.", "claims": [{"id": "claim-method", "statement": "To evaluate the correlation between the high expression of CCNF and other factors linked to OS, we conducted univariate and multivariate Cox regression analyses.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:34397798", "locator": "sections[10] \"CCNF expression hampered prognosis independently\" paragraph 2", "quote": "To evaluate the correlation between the high expression of CCNF and other factors linked to OS, we conducted univariate and multivariate Cox regression analyses."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:34397798", "locator": "sections[15] \"fn-group\" paragraph 1", "quote": "The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "partial", "objective": null, "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:34397798"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "blocked", "blocked_on": "data:accession_absent", "description": "The GEO series accession resolves and its sample accessions are listed. 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