High RPS27A Expression Predicts Poor Prognosis in Patients With HPV Type 16 Cervical Cancer.

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In addition, the vast majority of cervical cancer cases are caused by human papillomavirus (HPV) infection, of which HPV16 infection is the main cause and squamous cell carcinoma is the main presenting type. In this study, we performed screening of differentially expressed genes (DEGs) based on The Cancer Genome Atlas (TCGA) database and GSE6791, constructed a protein-protein interaction (PPI) network to screen 34 hub genes, filtered to the remaining 10 genes using the CytoHubba plug-in, and used survival analysis to determine that RPS27A was most associated with the prognosis of cervical cancer patients and has prognostic and predictive value for cervical cancer. The most significant biological functions and pathways of RPS27A enrichment were subsequently investigated with gene set enrichment analysis (GSEA), and integration of TCGA and GTEx database analyses revealed that RPS27A was significantly expressed in most cancer types. In this study, our analysis revealed that RPS27A can be used as a prognostic biomarker for HPV16 cervical cancer and has biological significance for the growth of cervical cancer cells.", "claims": [{"id": "claim-method", "statement": "Subsequently, Kaplan–Meier analysis was performed on 10 pivotal genes, and only RPS27A was significantly associated with the prognosis of cervical cancer ( Table 1 ).", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:34796111", "locator": "sections[13] \"RPS27A Is a Key Gene\" paragraph 2", "quote": "Subsequently, Kaplan–Meier analysis was performed on 10 pivotal genes, and only RPS27A was significantly associated with the prognosis of cervical cancer ( Table 1 )."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The original contributions presented in the study are included in the article/supplementary material. 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