Identification and development of a novel 5-gene diagnostic model based on immune infiltration analysis of osteoarthritis.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:34949204", "kind": "science-record", "revision": 5, "content_hash": "sha256:c6e1719d7cf07a52785ab58be84ea45e0675fcb2243c93eb5d1c61452f115b42", "created_at": "2026-11-01T17:36:39Z", "updated_at": "2026-11-01T22:48:06Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Identification and development of a novel 5-gene diagnostic model based on immune infiltration analysis of osteoarthritis.", "doi": "10.1186/s12967-021-03183-9", "pmid": "34949204", "authors": ["YaGuang Han", "Jun Wu", "ZhenYu Gong", "YiQin Zhou", "HaoBo Li", "Bo Wang", "QiRong Qian"], "journal": "Journal of translational medicine", "year": 2021, "abstract": "BACKGROUND: Osteoarthritis (OA), which is due to the progressive loss and degeneration of articular cartilage, is the leading cause of disability worldwide. Therefore, it is of great significance to explore OA biomarkers for the prevention, diagnosis, and treatment of OA.\nMETHODS AND MATERIALS: The GSE129147, GSE57218, GSE51588, GSE117999, and GSE98918 datasets with normal and OA samples were downloaded from the Gene Expression Omnibus (GEO) database. The GSE117999 and GSE98918 datasets were integrated, and immune infiltration was evaluated. The differentially expressed genes (DEGs) were analyzed using the limma package in R, and weighted gene co-expression network analysis (WGCNA) was used to explore the co-expression genes and co-expression modules. The co-expression module genes were analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. A protein-protein interaction (PPI) network was constructed using the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) database, and hub genes were identified by the degree, MNC, closeness, and MCC algorithms. The hub genes were used to construct a diagnostic model based on support vector machines.\nRESULTS: The Immune Score in the OA samples was significantly higher than in the normal samples, and a total of 2313 DEGs were identified. Through WGCNA, we found that the yellow module was significantly positively correlated with the OA samples and Immune Score and negatively correlated with the normal samples. The 142 DEGs of the yellow module were related to biological processes such as regulation of inflammatory response, positive regulation of inflammatory response, blood vessel morphogenesis, endothelial cell migration, and humoral immune response. The intersections of the genes obtained by the 4 algorithms resulted in 5 final hub genes, and the diagnostic model constructed with these 5 genes showed good performance in the training and validation cohorts.\nCONCLUSIONS: The 5-gene diagnostic model can be used to diagnose OA and guide clinical decision-making.", "claims": [{"id": "claim-method", "statement": "An SVM classification model was constructed, and the sensitivity, specificity, and area under the receiver operating characteristic (ROC) curve (AUC) of the model were analyzed.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:34949204", "locator": "sections[9] \"Diagnostic model construction and validation\" paragraph 2", "quote": "An SVM classification model was constructed, and the sensitivity, specificity, and area under the receiver operating characteristic (ROC) curve (AUC) of the model were analyzed."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The data used to support the findings of this study are available from the corresponding author on reasonable request.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:34949204", "locator": "sections[25] \"Availability of data and materials\" paragraph 2", "quote": "The data used to support the findings of this study are available from the corresponding author on reasonable request."}], "state": "complete"}, {"id": "claim-target-result", "statement": "The 5-gene diagnostic model can be used to diagnose OA and guide clinical decision-making.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:34949204", "locator": "sections[0] \"Abstract\" paragraph 4", "quote": "The 5-gene diagnostic model can be used to diagnose OA and guide clinical decision-making."}, {"asset": "source:pmid:34949204", "locator": "sections[17] \"Construction and validation of the diagnostic model\" paragraph 3", "quote": "These results indicated that the diagnostic prediction model constructed in this study could effectively distinguish OA samples from normal samples, and the 5 genes could be used as reliable biomarkers for OA diagnosis."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "The 5-gene diagnostic model can be used to diagnose OA and guide clinical decision-making.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:34949204"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. This lane did not download the dataset or read its licence.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE117999"], "outputs": ["the source data with its repository provenance"], "instruments": [], "reagents": []}, {"id": "run_analysis", "order": 3, "name": "Run the published analysis", "kind": "analysis", "state": "complete", "blocked_on": null, "description": "Apply the paper's statistical method to the resolved series and compare the result with the published target.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE117999"], "outputs": ["the replicated result and its comparison"], "instruments": [], "reagents": []}], "materials": [], "instruments": [], "reagents": [], "conditions": {}, "gaps": []}, "data": {"state": "partial", "assets": [{"id": "source:pmid:34949204", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.1186/s12967-021-03183-9", "sha256": "sha256:7a87632656a46be5158560cbc210de5a7b9d90a766b41bdbd4d9f2e282dbbde3", "bytes": 40266, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "10.1186/s12967-021-03183-9", "version": null, "note": "Full article fetched from PMC; the checksum covers the rendered section body, not the original XML bytes.", "structure": {"pmcid": "PMC8705150", "source": "europe_pmc_fulltext", "coverage": "whole_body", "text_hash_scope": "rendered_section_body"}}, {"id": "data:geo:GSE117999", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE117999", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE117999", "version": null, "note": "The data used to support the findings of this study are available from the corresponding author on reasonable request.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The data used to support the findings of this study are available from the corresponding author on reasonable request.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM3316962", "GSM3316963", "GSM3316964", "GSM3316965", "GSM3316966", "GSM3316967", "GSM3316968", "GSM3316969", "GSM3316970", "GSM3316971", "GSM3316972", "GSM3316973", "GSM3316974", "GSM3316975", "GSM3316976", "GSM3316977", "GSM3316978", "GSM3316979", "GSM3316980", "GSM3316981", "GSM3316982", "GSM3316983", "GSM3316984", "GSM3316985"], "sample_count": 24, "group_sizes": null, "group_sizes_basis": null, "platform": "20844", "taxon": "Homo sapiens", "title": "Transcriptome comparison of cartilage from patients with and without osteoarthritis", "resolution_checked_at": "2026-11-01T17:30:42Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE129147", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE129147", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE129147", "version": null, "note": "The data used to support the findings of this study are available from the corresponding author on reasonable request.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The data used to support the findings of this study are available from the corresponding author on reasonable request.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM3701266", "GSM3701267", "GSM3701268", "GSM3701269", "GSM3701270", "GSM3701271", "GSM3701272", "GSM3701273", "GSM3701274", "GSM3701275", "GSM3701276", "GSM3701277", "GSM3701278", "GSM3701279", "GSM3701280", "GSM3701281", "GSM3701282", "GSM3701283", "GSM3701284"], "sample_count": 19, "group_sizes": null, "group_sizes_basis": null, "platform": "15207", "taxon": "Homo sapiens", "title": "Comparison of the Damaged Cartilage with the Non-weight Bearing Healthy Cartilage", "resolution_checked_at": "2026-11-01T17:30:42Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE51588", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE51588", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE51588", "version": null, "note": "The data used to support the findings of this study are available from the corresponding author on reasonable request.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The data used to support the findings of this study are available from the corresponding author on reasonable request.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM1248759", "GSM1248760", "GSM1248761", "GSM1248762", "GSM1248763", "GSM1248764", "GSM1248765", "GSM1248766", "GSM1248767", "GSM1248768", "GSM1248769", "GSM1248770", "GSM1248771", "GSM1248772", "GSM1248773", "GSM1248774", "GSM1248775", "GSM1248776", "GSM1248777", "GSM1248778", "GSM1248779", "GSM1248780", "GSM1248781", "GSM1248782", "GSM1248783", "GSM1248784", "GSM1248785", "GSM1248786", "GSM1248787", "GSM1248788", "GSM1248789", "GSM1248790", "GSM1248791", "GSM1248792", "GSM1248793", "GSM1248794", "GSM1248795", "GSM1248796", "GSM1248797", "GSM1248798", "GSM1248799", "GSM1248800", "GSM1248801", "GSM1248802", "GSM1248803", "GSM1248804", "GSM1248805", "GSM1248806", "GSM1248807", "GSM1248808"], "sample_count": 50, "group_sizes": null, "group_sizes_basis": null, "platform": "13497", "taxon": "Homo sapiens", "title": "Genome-wide Expression Profiles of Subchondral Bone in Osteoarthritis", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE57218", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE57218", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE57218", "version": null, "note": "The data used to support the findings of this study are available from the corresponding author on reasonable request.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The data used to support the findings of this study are available from the corresponding author on reasonable request.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM1380887", "GSM1380888", "GSM1380889", "GSM1380890", "GSM1380891", "GSM1380892", "GSM1380893", "GSM1380894", "GSM1380895", "GSM1380896", "GSM1380897", "GSM1380898", "GSM1380899", "GSM1380900", "GSM1380901", "GSM1380902", "GSM1380903", "GSM1380904", "GSM1380905", "GSM1380906", "GSM1380907", "GSM1380908", "GSM1380909", "GSM1380910", "GSM1380911", "GSM1380912", "GSM1380913", "GSM1380914", "GSM1380915", "GSM1380916", "GSM1380917", "GSM1380918", "GSM1380919", "GSM1380920", "GSM1380921", "GSM1380922", "GSM1380923", "GSM1380924", "GSM1380925", "GSM1380926", "GSM1380927", "GSM1380928", "GSM1380929", "GSM1380930", "GSM1380931", "GSM1380932", "GSM1380933", "GSM1380934", "GSM1380935", "GSM1380936", "GSM1380937", "GSM1380938", "GSM1380939", "GSM1380940", "GSM1380941", "GSM1380942", "GSM1380943", "GSM1380944", "GSM1380945", "GSM1380946", "GSM1380947", "GSM1380948", "GSM1380949", "GSM1380950", "GSM1380951", "GSM1380952", "GSM1380953", "GSM1380954", "GSM1380955", "GSM1380956", "GSM1380957", "GSM1380958", "GSM1380959"], "sample_count": 73, "group_sizes": null, "group_sizes_basis": null, "platform": "6947", "taxon": "Homo sapiens", "title": "Gene expression profiles from joint-matched macroscopically intact and OA affected cartilage of patients undergoing joint replacement surgery due to end-stage OA", "resolution_checked_at": "2026-11-01T17:30:42Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE73626", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE73626", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE73626", "version": null, "note": "The data used to support the findings of this study are available from the corresponding author on reasonable request.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The data used to support the findings of this study are available from the corresponding author on reasonable request.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM1899667", "GSM1899668", "GSM1899669", "GSM1899670", "GSM1899671", "GSM1899672", "GSM1899673", "GSM1899674", "GSM1899675", "GSM1899676", "GSM1899677", "GSM1899678", "GSM1899679", "GSM1899680", "GSM1899681", "GSM1899682", "GSM1899683", "GSM1899684"], "sample_count": 18, "group_sizes": null, "group_sizes_basis": null, "platform": "13534", "taxon": "Homo sapiens", "title": "Genome-wide DNA methylation study of hip and knee osteoarthritic and healthy cartilage reveals embryonic organ and skeletal system morphogenesis as major pathways involved in osteoarthritis", "resolution_checked_at": "2026-11-01T17:30:42Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE98918", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE98918", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE98918", "version": null, "note": "The data used to support the findings of this study are available from the corresponding author on reasonable request.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The data used to support the findings of this study are available from the corresponding author on reasonable request.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM2627518", "GSM2627519", "GSM2627520", "GSM2627521", "GSM2627522", "GSM2627523", "GSM2627524", "GSM2627525", "GSM2627526", "GSM2627527", "GSM2627528", "GSM2627529", "GSM2627530", "GSM2627531", "GSM2627532", "GSM2627533", "GSM2627534", "GSM2627535", "GSM2627536", "GSM2627537", "GSM2627538", "GSM2627539", "GSM2627540", "GSM2627541"], "sample_count": 24, "group_sizes": null, "group_sizes_basis": null, "platform": "20844", "taxon": "Homo sapiens", "title": "The Impact of Osteoarthritis on the Biology of the Meniscus:", "resolution_checked_at": "2026-11-01T17:30:42Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}], "gaps": ["asset:data:geo:GSE117999 not downloaded", "asset:data:geo:GSE117999 licence not read", "asset:data:geo:GSE129147 not downloaded", "asset:data:geo:GSE129147 licence not read", "asset:data:geo:GSE51588 not downloaded", "asset:data:geo:GSE51588 licence not read", "asset:data:geo:GSE57218 not downloaded", "asset:data:geo:GSE57218 licence not read", "asset:data:geo:GSE73626 not downloaded", "asset:data:geo:GSE73626 licence not read", "asset:data:geo:GSE98918 not downloaded", "asset:data:geo:GSE98918 licence not read"]}, "analysis": {"state": "partial", "methods": [{"id": "method-1", "family": "machine_learning", "specific": "support_vector_machine", "label": "Machine learning", "dsl_operations": ["train_classifier", "cross_validate", "roc_auc"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["labelled_feature_matrix"], "evidence": {"score": 1.0, "band": "verbatim", "quote": "An SVM classification model was constructed, and the sensitivity, specificity, and area under the receiver operating characteristic (ROC) curve (AUC) of the model were analyzed."}}, {"id": "method-2", "family": "differential_expression", "specific": "limma_voom", "label": "Differential expression analysis", "dsl_operations": ["normalise_counts", "differential_expression_fit", "fdr_bh"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["count_matrix_with_condition"], "evidence": {"score": 0.7, "band": "medium", "quote": "limma"}}, {"id": "method-3", "family": "network_analysis", "specific": "ppi_network", "label": "Network / pathway analysis", "dsl_operations": ["build_graph", "centrality_scores", "pathway_enrich"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["edge_list"], "evidence": {"score": 0.7, "band": "medium", "quote": "protein-protein interaction"}}], "targets": [], "gaps": ["method.reader_differs_from_extractor"]}, "capability": {"state": "complete", "requirements": [{"capability_id": "capability:computational_analysis", "label": "Computational analysis platform", "assay_families": ["meta_analysis", "machine_learning", "survival_analysis", "statistical_regression", "pca", "molecular_docking", "network_analysis", "differential_expression", "gwas"], "availability_state": "owned", "tier_unlocked": "R1", "candidate": "Automated Assays Laravel application and simulated adapters"}], "gaps": []}, "readiness": {"state": "complete", "tier": "R1", "blocking_axis": "none", "blocked_on": "nothing:replicable_now", "axes": {"method": {"tier": "R1", "expressible": true, "required_operations": ["train_classifier", "cross_validate", "roc_auc"], "missing_operations": [], "basis": "The paper names the method it used and the corpus's method extractor maps it onto the DSL catalogue: support_vector_machine."}, "capability": {"tier": "R1", "capability_id": "capability:computational_analysis", "availability_state": "owned", "basis": "The computational analysis is owned. The physical bench the paper used is not, so a physical validation cannot be run here."}, "data": {"tier": "R1", "reachable": true, "accessions": ["GSE129147", "GSE57218", "GSE51588", "GSE117999", "GSE98918", "GSE73626"], "resolved_accessions": ["GSE129147", "GSE57218", "GSE51588", "GSE117999", "GSE98918", "GSE73626"], "statements": ["The data used to support the findings of this study are available from the corresponding author on reasonable request."], "basis": "The paper names GSE129147, GSE57218, GSE51588, GSE117999, GSE98918, GSE73626 in Gene Expression Omnibus (GEO) and the accession resolves in the repository. No dataset was downloaded and no licence was read."}}, "can_run": {"dsl_operations": ["train_classifier", "cross_validate", "roc_auc"], "assets": ["source:pmid:34949204", "data:geo:GSE117999"], "steps": ["run_analysis"]}, "must_build": {"dsl_operations": [], "converters": [], "readers": [], "capabilities": [], "data_gaps": ["data:geo:GSE117999"]}, "gaps": []}, "review": {"state": "partial", "machine_critique": {"kind": "extraction_review", "reader": {"model": "MiniMax-M3.1-Flash", "provider": "minimax", "provider_family": "minimax", "read_at": "2026-11-01T17:12:58Z", "independence": "single_reader"}, "evidence_check": {"method": "verbatim", "availability": "verbatim"}, "calls": 5, "usage": {"prompt_tokens": 12031, "completion_tokens": 1864, "cached_tokens": 264}}, "human_critique": null, "stages": [{"id": "extraction", "state": "complete", "reader": "MiniMax-M3.1-Flash", "provider": "minimax"}], "gaps": ["review.independent_reader", "review.machine_critique", "review.human_critique"]}, "execution": {"state": "absent", "status": "not_run", "mode": null, "runs": [], "gaps": ["execution.not_run"]}, "provenance": {"entities": [{"id": "pmid:34949204", "type": "paper", "label": "pmid:34949204"}, {"id": "source:pmid:34949204", "type": "manuscript", "label": "PMID 34949204 full text"}, {"id": "data:geo:GSE117999", "type": "dataset", "label": "GEO GSE117999"}], "activities": [{"id": "activity-reading-sci-2026-11-01", "type": "classification", "used": [{"id": "pmid:34949204", "type": "paper", "label": "pmid:34949204"}, {"id": "source:pmid:34949204", "type": "manuscript", "label": "PMID 34949204 full text"}, {"id": "data:geo:GSE117999", "type": "dataset", "label": "GEO GSE117999"}], "agent": "agent:corpus-assay-engine"}, {"id": "activity-read-34949204", "type": "extraction", "used": ["source:pmid:34949204"], "agent": "agent:minimax-reader"}, {"id": "activity-resolve-GSE117999", "type": "accession_resolution", "used": ["data:geo:GSE117999"], "agent": "agent:corpus-assay-engine"}], "agents": [{"id": "agent:corpus-assay-engine", "type": "software", "label": "Corpus assay engine"}, {"id": "agent:minimax-reader", "type": "software", "label": "MiniMax literature reader"}], "source_run_id": "reading-sci-2026-11-01", "dsl_catalogue_fingerprint": "343fb30756ba6ec3", "capability_table_fingerprint": "2cb3e42f047d2ecf", "snapshot_id": "ba34b49490d9bfaf"}, "lineage": {"parent_id": "pmid:34949204", "parent_hash": "sha256:466800504713ac48b41308281b635f8ce235287cac2cfbc3c7226cd5c244e770", "fork_of": null, "generation": 4}, "gaps": ["asset:data:geo:GSE117999 licence not read", "asset:data:geo:GSE117999 not downloaded", "asset:data:geo:GSE129147 licence not read", "asset:data:geo:GSE129147 not downloaded", "asset:data:geo:GSE51588 licence not read", "asset:data:geo:GSE51588 not downloaded", "asset:data:geo:GSE57218 licence not read", "asset:data:geo:GSE57218 not downloaded", "asset:data:geo:GSE73626 licence not read", "asset:data:geo:GSE73626 not downloaded", "asset:data:geo:GSE98918 licence not read", "asset:data:geo:GSE98918 not downloaded", "execution.not_run", "method.reader_differs_from_extractor", "review.human_critique", "review.independent_reader", "review.machine_critique"], "assays": [{"role": "analysis", "definition_id": "machine_learning", "definition_version": "f2132e96ae6c7a4e", "definition_digest": null, "required_operations": ["train_classifier", "cross_validate", "roc_auc"], "support_state": "supported", "source_hashes": {"dsl_catalogue": "f2132e96ae6c7a4e"}, "confidence": 1.0, "evidence": ["An SVM classification model was constructed, and the sensitivity, specificity, and area under the receiver operating characteristic (ROC) curve (AUC) of the model were analyzed."], "order_basis": "analysis_only", "id": "assay:1"}]}