FAM3B Serves as a Biomarker for the Development and Malignancy of Oral Lichen Planus.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:35082524", "kind": "science-record", "revision": 5, "content_hash": "sha256:2928e275f31fa3bb335cd4e4b9f7681afa215f8b83e1ef69e6916a0b3e002ec1", "created_at": "2026-11-01T17:36:48Z", "updated_at": "2026-11-01T22:05:41Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "FAM3B Serves as a Biomarker for the Development and Malignancy of Oral Lichen Planus.", "doi": "10.2147/IJGM.S346617", "pmid": "35082524", "authors": ["Wenfang Wang", "Meijuan Wang", "Madiha Mohammed Saleh Ahmed", "Yunshan Zhao", "Hao Wu", "Mazen Musa", "Xi Chen"], "journal": "International journal of general medicine", "year": 2022, "abstract": "PURPOSE: Oral lichen planus (OLP) is a potentially malignant condition with unclear etiology. This study aimed to identify potential biomarkers and mechanisms for OLP progression through bioinformatics analyses.\nMETHODS: Gene Expression Omnibus (GEO) datasets were screened to identify differentially expressed genes (DEGs) between OLP patients and healthy individuals. The functions and enriched pathways of the DEGs were identified. Sequencing dataset GSE70665 was then used to analyze the role of DEGs in the development of OLP to oral squamous cell carcinoma (OSCC). Oncomine and The Cancer Genome Atlas (TCGA) databases were utilized to evaluate clinicopathological characters of OSCC. Univariate and multivariate Cox regression models were used to identify independent prognostic factors.\nRESULTS: A total of 24 DEGs were identified between OLP and normal samples. FAM3B was under-expressed in OLP compared with normal samples and was further significantly downregulated in OSCC compared with OLP. Under-expression of FAM3B was significantly correlated with tumor stage and disease-specific survival (DSS), progression-free interval (PFI) and overall survival (OS) of OSCC patients. With univariate and multivariate Cox regression analysis, FAM3B was an independent prognostic factor.\nCONCLUSION: Under-expression of FAM3B was associated with the development and malignancy of OLP. FAM3B may serve as a potential prognostic biomarker for OLP.", "claims": [{"id": "claim-method", "statement": "Univariate and multivariate Cox regression models were used to identify independent prognostic factors.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:35082524", "locator": "sections[0] \"Abstract\" paragraph 2", "quote": "Univariate and multivariate Cox regression models were used to identify independent prognostic factors."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The data sets used in this study are publicly available (https://www.ncbi.nlm.nih.gov/), and all the related data can be obtained from Wenfang Wang (email: wwf15127@stu.xjtu.edu.cn) upon reasonable request.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:35082524", "locator": "sections[19] \"Data Sharing Statement\" paragraph 2", "quote": "The data sets used in this study are publicly available (https://www.ncbi.nlm.nih.gov/), and all the related data can be obtained from Wenfang Wang (email: wwf15127@stu.xjtu.edu.cn) upon reasonable request."}], "state": "complete"}, {"id": "claim-target-result", "statement": "Under-expression of FAM3B was associated with the development and malignancy of OLP.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:35082524", "locator": "sections[0] \"Abstract\" paragraph 4", "quote": "Under-expression of FAM3B was associated with the development and malignancy of OLP."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "Under-expression of FAM3B was associated with the development and malignancy of OLP.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:35082524"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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