hsa_circ_0072309 Expression Profiling in Non-small-Cell Lung Carcinoma and Its Implications for Diagnosis and Prognosis.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:35284481", "kind": "science-record", "revision": 5, "content_hash": "sha256:045ee74c0e2541efcdf48c98706f0561650cbcb7edf2589cae801b53bb4c8f5b", "created_at": "2026-11-01T18:14:04Z", "updated_at": "2026-11-01T22:48:40Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "hsa_circ_0072309 Expression Profiling in Non-small-Cell Lung Carcinoma and Its Implications for Diagnosis and Prognosis.", "doi": "10.3389/fsurg.2022.842292", "pmid": "35284481", "authors": ["Yong Zhou", "Zhongkai Tong", "Xiaoxiao Zhu", "Shaoqing Huang", "Zhaoxing Dong", "Zhenyue Ye"], "journal": "Frontiers in surgery", "year": 2022, "abstract": "Circular RNAs (circRNAs), which fall into the category of endogenous ncRNAs, are linked to disease progression of neoplastic diseases. Whereas, it remains uncharacterized regarding hsa_circ_0072309's function and implications in lung carcinoma (LC). Gene Expression Omnibus (GEO) database was utilized for identifying circRNAs with aberrantly expression in LC. qRT-PCR was responsible for determining hsa_circ_0072309 levels in lung adenocarcinoma (LAC). Also, its involvement in LC cell progression was investigated. Experimentally, hsa_circ_0072309 was identified as one of the most aberrantly down-regulated circRNAs in the GEO database (GSE101684 and GSE112214). qRT-PCR revealed notably down-regulated hsa_circ_0072309 in LAC tissue, which had a close association with adverse 3-year survival, as well as LNM and advanced TNM stage. Based on ROC, the AUC of hsa_circ_0072309 was determined to be 0.887, and its specificity and susceptibility can be improved by combined detection of either CYFRA21-1 or CEA. In a word, hsa_circ_0072309 is lowly expressed in lung cancer patients and the survival rate of lowly expressed patients is significantly lower, a candidate marker with prognostic utility for the disease.", "claims": [{"id": "claim-method", "statement": "ROC curves were used for assessing the diagnostic implications of serum hsa_circ_0072309.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:35284481", "locator": "sections[9] \"Statistical Processing\" paragraph 2", "quote": "ROC curves were used for assessing the diagnostic implications of serum hsa_circ_0072309."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The datasets presented in this study can be found in online repositories. 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