A risk model of 10 aging-related genes for predicting survival and immune response in triple-negative breast cancer.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:35297220", "kind": "science-record", "revision": 3, "content_hash": "sha256:f2d19252c92d7fe7ebb1ce0a7143ab6f82beff611c6ff7f136efd7477ee13337", "created_at": "2026-11-01T18:14:05Z", "updated_at": "2026-11-01T21:27:27Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "A risk model of 10 aging-related genes for predicting survival and immune response in triple-negative breast cancer.", "doi": "10.1002/cam4.4674", "pmid": "35297220", "authors": ["Xia Yang", "Yanhua Sun", "Xia Liu", "Zhinong Jiang"], "journal": "Cancer medicine", "year": 2022, "abstract": "Accumulated studies showed that the clinical significance of aging on the development and malignancy of tumors, while the relationship between aging and the prognosis, immune response in triple-negative breast cancer (TNBC) has not been well clarified. Here, we constructed a risk model of 10 prognostic aging-related genes (ARGs) from METABRIC database. Then, TNBC patients were classified into high- and low-risk groups, the survival diversity, immune response, genomic function, and tumor mutation burden (TMB) between different risk groups were explored in METABRIC, TCGA, and GSE58812 cohorts. Results showed that patients in the high-risk group had poorer survival outcomes compared to their counterparts (all p < 0.05), and the nomogram we established showed reliable prediction ability for survival in TNBC patients. Besides, TNBC patients with high-risk scores had a lower expression of immune checkpoint markers and a lower fraction of activated immune cells. Furthermore, GSEA showed that Notch signaling pathway was significantly enriched in the high-risk group. Thus, a risk model based on the aging-related genes was developed and validated in this study, which may serve as a potential biomarker for prognosis and personalized treatment in TNBCs.", "claims": [{"id": "claim-method", "statement": "Using the R package “survival”, prognosis‐associated ARGs were selected according to the standard of p < 0.05 by univariate Cox analysis. Then, using the R package “glmnet”, 32 the most robust prognostic ARGs were selected in the LASSO Cox regression. Finally, a risk model based on 10 selected ARGs was established.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:35297220", "locator": "sections[4] \"Identify prognostic ARGs and establish a risk model based on selected ARGs\" paragraph 2", "quote": "Using the R package “survival”, prognosis‐associated ARGs were selected according to the standard of p < 0.05 by univariate Cox analysis. Then, using the R package “glmnet”, 32 the most robust prognostic ARGs were selected in the LASSO Cox regression. Finally, a risk model based on 10 selected ARGs was established."}], "state": "complete"}, {"id": "claim-data-access", "statement": "Data sharing is not applicable to this article as no new data were created or analyzed in this study.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:35297220", "locator": "sections[29] \"DATA AVAILABILITY STATEMENT\" paragraph 2", "quote": "Data sharing is not applicable to this article as no new data were created or analyzed in this study."}], "state": "complete"}, {"id": "claim-target-result", "statement": "Patients in the high-risk group had poorer survival outcomes than their counterparts, and the nomogram showed reliable prediction ability for survival in TNBC patients.", "kind": "quantitative", "target": {"value": 0.05, "unit": "p-value", "tolerance": null, "source": "Results showed that patients in the high‐risk group had poorer survival outcomes compared to their counterparts (all p < 0.05), and the nomogram we established showed reliable prediction ability for survival in TNBC patients."}, "evidence": [{"asset": "source:pmid:35297220", "locator": "sections[0] \"Abstract\" paragraph 1", "quote": "Results showed that patients in the high‐risk group had poorer survival outcomes compared to their counterparts (all p < 0.05), and the nomogram we established showed reliable prediction ability for survival in TNBC patients."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "partial", "objective": "Patients in the high-risk group had poorer survival outcomes than their counterparts, and the nomogram showed reliable prediction ability for survival in TNBC patients.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:35297220"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "blocked", "blocked_on": "data:accession_absent", "description": "The GEO series accession resolves and its sample accessions are listed. 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