X-box binding protein 1 (XBP1): a potential role in chemotherapy response, clinical pathologic features, non-inflamed tumour microenvironment for breast cancer.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:35543228", "kind": "science-record", "revision": 3, "content_hash": "sha256:17b7c35d86e775185be240e7f6b7972b7f6f797263001feebbabd979f1199324", "created_at": "2026-11-01T18:14:26Z", "updated_at": "2026-11-01T21:27:50Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "X-box binding protein 1 (XBP1): a potential role in chemotherapy response, clinical pathologic features, non-inflamed tumour microenvironment for breast cancer.", "doi": "10.1042/BSR20220225", "pmid": "35543228", "authors": ["Zhipeng Zhu", "Hongliang Zhan", "Anran Sun", "Heqing Huang", "Baisheng Chen", "Fuxing Zhang"], "journal": "Bioscience reports", "year": 2022, "abstract": "X-box binding protein 1 (XBP1) is mainly expressed in breast cancer (BC) in human cancers. Its tumorigenesis and favourable prognosis are contradictory, and its essential role in chemotherapeutic response and immunosuppression is unknown in BC. The study firstly identified XBP1 who received neoadjuvant chemotherapy (NAC) from GSE25055 and GSE24460. Associations between XBP1 expression and clinicopathological characteristics was investigated using Oncomine, TCGA, UALCAN and bc-GenExMiner. The prognostic value of XBP1 was assessed using the Kaplan-Meier Plotter, bc-GenExMiner, GSE25055, and GSE25056. Furthermore, we systematically correlated XBP1 and immunological characteristics in the BC tumour microenvironment (TME) using TISIDB, TIMER, GSE25055, GSE25056 and TCGA dataset. Finally, an essential role of XBP1 in chemotherapy response was evaluated based on GSE25055, GSE25065, GSE24460, GSE5846, ROC Plotter and CELL databases. Furthermore, XBP1 mRNA expression levels were obviously highest in BC among human cancers and were significantly related to a good prognosis. In addition, XBP1 mRNA and protein levels were higher in the luminal subtype than in normal tissues and basal-like subtype, which might be attributed to membrane transport-related processes. Apart from BC, negative immunological correlations of XBP1 were not observed in other malignancies. XBP1 might shape the non-inflamed TME in BC. Finally, XBP1 expression was higher in chemo-resistive than chemo-sensitive cases, it had a predictive value and could independently predict chemotherapy response in BC patients receiving NAC. Our study suggests that the essential role of XBP1 in clinical pathologic features, non-inflamed TME, chemotherapy response in BC.", "claims": [{"id": "claim-method", "statement": "Univariate logistic-regression showed that high XBP1 mRNA expression level was associated with good response. Multivariate logistic regression revealed that XBP1 expression was independently associated with chemotherapy response in BC patients (Table 6).", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:35543228", "locator": "sections[18] \"High XBP1 expression indicated high chemosensitivity\" paragraph 7", "quote": "Univariate logistic-regression showed that high XBP1 mRNA expression level was associated with good response. Multivariate logistic regression revealed that XBP1 expression was independently associated with chemotherapy response in BC patients (Table 6)."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The original contributions presented in the study are publicly available. These data can be found here: GEO dataset (https://www.ncbi.nlm.nih.gov/gds and TCGA dataset (https://portal.gdc.cancer.gov/repository).", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:35543228", "locator": "sections[25] \"Data Availability\" paragraph 2", "quote": "The original contributions presented in the study are publicly available. These data can be found here: GEO dataset (https://www.ncbi.nlm.nih.gov/gds and TCGA dataset (https://portal.gdc.cancer.gov/repository)."}], "state": "complete"}, {"id": "claim-target-result", "statement": "High XBP1 expression indicated high chemosensitivity, good prognosis, and a non-inflamed tumour microenvironment in breast cancer patients.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:35543228", "locator": "sections[0] \"Abstract\" paragraph 1", "quote": "Finally, XBP1 expression was higher in chemo-resistive than chemo-sensitive cases, it had a predictive value and could independently predict chemotherapy response in BC patients receiving NAC."}, {"asset": "source:pmid:35543228", "locator": "sections[20] \"Discussion\" paragraph 5", "quote": "In summary, XBP1 expression level obviously increased in BC patients, especially in patients with luminal BC, and high XBP1 expression indicated high chemosensitivity, good prognosis, and a non-inflamed tumour microenvironment in BC patients."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "High XBP1 expression indicated high chemosensitivity, good prognosis, and a non-inflamed tumour microenvironment in breast cancer patients.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:35543228"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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