Intra-tumoral angiogenesis correlates with immune features and prognosis in glioma.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:35579998", "kind": "science-record", "revision": 5, "content_hash": "sha256:23e4ae223e3ea5064fa49dce89a9d00b61572032ab1cba0240068e0927070d67", "created_at": "2026-11-01T18:14:28Z", "updated_at": "2026-11-01T22:49:04Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Intra-tumoral angiogenesis correlates with immune features and prognosis in glioma.", "doi": "10.18632/aging.204079", "pmid": "35579998", "authors": ["Qing Zhang", "Yao-Xing Guo", "Wan-Lin Zhang", "Hai-Yan Lian", "Natasha Iranzad", "Endi Wang", "Ying-Chun Li", "Hai-Chao Tong", "Le-Yao Li", "Ling-Yun Dong", "Lian-He Yang", "Shuang Ma"], "journal": "Aging", "year": 2022, "abstract": "Gliomas are the most common malignant tumor in the brain. As with other tumors, the progression of glioma depends on intra-tumoral angiogenesis. However, the effect of angiogenesis on gliomas is still not fully understood. In this study, we developed an angiogenesis pathway score using Gene Set Variation Analysis (GSAV) in R to assess the status of intra-glioma angiogenesis in The Cancer Genome Atlas (TCGA), Chinese Glioma Genome Atlas (CGGA mRNAseq_325, CGGA mRNA-array), and GSE16011 datasets. We found that the angiogenesis pathway score not only accurately predicted the prognosis of glioma patients, but also accurately distinguished the malignant phenotype and immune characteristics of gliomas. In addition, as an independent prognostic factor, the score could predict glioma sensitivity to radiotherapy and chemotherapy. In summary, we used the angiogenesis pathway score to reveal the relationship between glioma angiogenesis and the malignant phenotype, immune characteristics, and prognosis of glioma.", "claims": [{"id": "claim-method", "statement": "The overall survival (OS) difference between the high- and low-score groups was determined using the Kaplan-Meier (KM) method of the survival R package. Univariate and multivariate Cox regression analyses were conducted using the survival package to assess the independence of the angiogenesis pathway score in predicting the OS of glioma patients.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:35579998", "locator": "sections[16] \"Prognosis analyses\" paragraph 2", "quote": "The overall survival (OS) difference between the high- and low-score groups was determined using the Kaplan-Meier (KM) method of the survival R package. Univariate and multivariate Cox regression analyses were conducted using the survival package to assess the independence of the angiogenesis pathway score in predicting the OS of glioma patients."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The datasets used in this study can be downloaded from: http://www.cgga.org.cn/ (CGGA), https://portal.gdc.cancer.gov/ (TCGA), and https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE16011 (GSE16011).", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:35579998", "locator": "sections[19] \"Data availability statement\" paragraph 2", "quote": "The datasets used in this study can be downloaded from: http://www.cgga.org.cn/ (CGGA), https://portal.gdc.cancer.gov/ (TCGA), and https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE16011 (GSE16011)."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:35579998"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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