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pmid:35619902
Development and Validation of a Risk Prediction Model for Breast Cancer Prognosis Based on Depression-Related Genes.
Xuan Wang · Neng Wang · Linda L D Zhong · Kexin Su · Shengqi Wang · Yifeng Zheng · Bowen Yang · Juping Zhang · Bo Pan · Wei Yang · Zhiyu Wang
Frontiers in oncology · 2022 doi:10.3389/fonc.2022.879563
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Experiment
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Data
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Analysis
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Execution
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Complete file
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However, a precise risk model is lacking to evaluate the potential impact of depression on breast cancer prognosis. In this study, we established a depression-related gene (DRG) signature that can predict overall survival (OS) and elucidate its correlation with pathological parameters and sensitivity to therapy in breast cancer.\nMethods: The model training and validation assays were based on the analyses of 1,096 patients from The Cancer Genome Atlas (TCGA) database and 2,969 patients from GSE96058. A risk signature was established through univariate and multivariate Cox regression analyses.\nResults: Ten DRGs were determined to construct the risk signature. Multivariate analysis revealed that the signature was an independent prognostic factor for OS. Receiver operating characteristic (ROC) curves indicated good performance of the model in predicting 1-, 3-, and 5-year OS, particularly for patients with triple-negative breast cancer (TNBC). In the high-risk group, the proportion of immunosuppressive cells, including M0 macrophages, M2 macrophages, and neutrophils, was higher than that in the low-risk group. Furthermore, low-risk patients responded better to chemotherapy and endocrine therapy. Finally, a nomogram integrating risk score, age, tumor-node-metastasis (TNM) stage, and molecular subtypes were established, and it showed good agreement between the predicted and observed OS.\nConclusion: The 10-gene risk model not only highlights the significance of depression in breast cancer prognosis but also provides a novel gene-testing tool to better prevent the potential adverse impact of depression on breast cancer prognosis.", "claims": [{"id": "claim-method", "statement": "A risk signature was established through univariate and multivariate Cox regression analyses.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:35619902", "locator": "sections[0] \"Abstract\" paragraph 2", "quote": "A risk signature was established through univariate and multivariate Cox regression analyses."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The original contributions presented in the study are included in the article/ Supplementary Material . Further inquiries can be directed to the corresponding author.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:35619902", "locator": "sections[22] \"Data Availability Statement\" paragraph 2", "quote": "The original contributions presented in the study are included in the article/ Supplementary Material . Further inquiries can be directed to the corresponding author."}], "state": "complete"}, {"id": "claim-target-result", "statement": "As displayed in Figure 3E , the maximum area under the ROC curve (AUC) values reached 0.789, indicating the good sensitivity and specificity of the model.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:35619902", "locator": "sections[15] \"Prognostic Effect of the Model on Predicting OS of Breast Cancer\" paragraph 2", "quote": "As displayed in Figure 3E , the maximum area under the ROC curve (AUC) values reached 0.789, indicating the good sensitivity and specificity of the model."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "As displayed in Figure 3E , the maximum area under the ROC curve (AUC) values reached 0.789, indicating the good sensitivity and specificity of the model.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:35619902"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. This lane did not download the dataset or read its licence.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE96058"], "outputs": ["the source data with its repository provenance"], "instruments": [], "reagents": []}, {"id": "run_analysis", "order": 3, "name": "Run the published analysis", "kind": "analysis", "state": "complete", "blocked_on": null, "description": "Apply the paper's statistical method to the resolved series and compare the result with the published target.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE96058"], "outputs": ["the replicated result and its comparison"], "instruments": [], "reagents": []}], "materials": [], "instruments": [], "reagents": [], "conditions": {}, "gaps": []}, "data": {"state": "partial", "assets": [{"id": "source:pmid:35619902", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.3389/fonc.2022.879563", "sha256": "sha256:f856e3e3c271bd63c34cdfc4a97ffc406726e1f68e43666c7462b4be6e009fe9", "bytes": 46213, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "10.3389/fonc.2022.879563", "version": null, "note": "Full article fetched from PMC; the checksum covers the rendered section body, not the original XML bytes.", "structure": {"pmcid": "PMC9128552", "source": "europe_pmc_fulltext", "coverage": "whole_body", "text_hash_scope": "rendered_section_body"}}, {"id": "data:geo:GSE96058", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE96058", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE96058", "version": null, "note": "The original contributions presented in the study are included in the article/ Supplementary Material . 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"GSM2528779", "GSM2528780", "GSM2528781", "GSM2528782", "GSM2528783", "GSM2528784", "GSM2528785", "GSM2528786", "GSM2528787", "GSM2528788", "GSM2528789", "GSM2528790", "GSM2528791", "GSM2528792", "GSM2528793", "GSM2528794", "GSM2528795", "GSM2528796", "GSM2528797", "GSM2528798", "GSM2528799", "GSM2528800", "GSM2528801", "GSM2528802", "GSM2528803", "GSM2528804", "GSM2528805", "GSM2528806", "GSM2528807", "GSM2528808", "GSM2528809", "GSM2528810", "GSM2528811", "GSM2528812", "GSM2528813", "GSM2528814", "GSM2528815", "GSM2528816", "GSM2528817", "GSM2528818", "GSM2528819", "GSM2528820", "GSM2528821", "GSM2528822", "GSM2528823", "GSM2528824", "GSM2528825", "GSM2528826", "GSM2528827", "GSM2528828", "GSM2528829", "GSM2528830", "GSM2528831", "GSM2528832", "GSM2528833", "GSM2528834", "GSM2528835", "GSM2528836", "GSM2528837", "GSM2528838", "GSM2528839", "GSM2528840", "GSM2528841", "GSM2528842", "GSM2528843", "GSM2528844", "GSM2528845", "GSM2528846", "GSM2528847", "GSM2528848", "GSM2528849", "GSM2528850", "GSM2528851", "GSM2528852", "GSM2528853", "GSM2528854", "GSM2528855", "GSM2528856", "GSM2528857", "GSM2528858", "GSM2528859", "GSM2528860", "GSM2528861", "GSM2528862", "GSM2528863", "GSM2528864", "GSM2528865", "GSM2528866", "GSM2528867", "GSM2528868", "GSM2528869", "GSM2528870", "GSM2528871", "GSM2528872", "GSM2528873", "GSM2528874", "GSM2528875", "GSM2528876", "GSM2528877", "GSM2528878", "GSM2528879", "GSM2528880", "GSM2528881", "GSM2528882", "GSM2528883", "GSM2528884", "GSM2528885", "GSM2528886", "GSM2528887", "GSM2528888", "GSM2528889", "GSM2528890", "GSM2528891", "GSM2528892", "GSM2528893", "GSM2528894", "GSM2528895", "GSM2528896", "GSM2528897", "GSM2528898", "GSM2528899", "GSM2528900", "GSM2528901", "GSM2528902", "GSM2528903", "GSM2528904", "GSM2528905", "GSM2528906", "GSM2528907", "GSM2528908", "GSM2528909", "GSM2528910", "GSM2528911", "GSM2528912", "GSM2528913", "GSM2528914", "GSM2528915", "GSM2528916", "GSM2528917", "GSM2528918", "GSM2528919", "GSM2528920", "GSM2528921", "GSM2528922", "GSM2528923", "GSM2528924", "GSM2528925", "GSM2528926", "GSM2528927", "GSM2528928", "GSM2528929", "GSM2528930", "GSM2528931", "GSM2528932", "GSM2528933", "GSM2528934", "GSM2528935", "GSM2528936", "GSM2528937", "GSM2528938", "GSM2528939", "GSM2528940", "GSM2528941", "GSM2528942", "GSM2528943", "GSM2528944", "GSM2528945", "GSM2528946", "GSM2528947", "GSM2528948", "GSM2528949", "GSM2528950", "GSM2528951", "GSM2528952", "GSM2528953", "GSM2528954", "GSM2528955", "GSM2528956", "GSM2528957", "GSM2528958", "GSM2528959", "GSM2528960", "GSM2528961", "GSM2528962", "GSM2528963", "GSM2528964", "GSM2528965", "GSM2528966", "GSM2528967", "GSM2528968", "GSM2528969", "GSM2528970", "GSM2528971", "GSM2528972", "GSM2528973", "GSM2528974", "GSM2528975", "GSM2528976", "GSM2528977", "GSM2528978", "GSM2528979", "GSM2528980", "GSM2528981", "GSM2528982", "GSM2528983", "GSM2528984", "GSM2528985", "GSM2528986", "GSM2528987", "GSM2528988", "GSM2528989", "GSM2528990", "GSM2528991", "GSM2528992", "GSM2528993", "GSM2528994", "GSM2528995", "GSM2528996", "GSM2528997", "GSM2528998", "GSM2528999", "GSM2529000", "GSM2529001", "GSM2529002", "GSM2529003", "GSM2529004", "GSM2529005", "GSM2529006", "GSM2529007", "GSM2529008", "GSM2529009", "GSM2529010", "GSM2529011", "GSM2529012", "GSM2529013", "GSM2529014", "GSM2529015", "GSM2529016", "GSM2529017", "GSM2529018", "GSM2529019", "GSM2529020", "GSM2529021", "GSM2529022", "GSM2529023", "GSM2529024", "GSM2529025", "GSM2529026", "GSM2529027", "GSM2529028", "GSM2529029", "GSM2529030", "GSM2529031", "GSM2529032", "GSM2529033", "GSM2529034", "GSM2529035", "GSM2529036", "GSM2529037", "GSM2529038", "GSM2529039", "GSM2529040", "GSM2529041", "GSM2529042", "GSM2529043", "GSM2529044", "GSM2529045", "GSM2529046", "GSM2529047", "GSM2529048", "GSM2529049", "GSM2529050", "GSM2529051", "GSM2529052", "GSM2529053", "GSM2529054", "GSM2529055", "GSM2529056", "GSM2529057", "GSM2529058", "GSM2529059", "GSM2529060", "GSM2529061", "GSM2529062", "GSM2529063", "GSM2529064", "GSM2529065", "GSM2529066", "GSM2529067", "GSM2529068", "GSM2529069", "GSM2529070", "GSM2529071", "GSM2529072", "GSM2529073", "GSM2529074", "GSM2529075", "GSM2529076", "GSM2529077", "GSM2529078", "GSM2529079", "GSM2529080", "GSM2529081", "GSM2529082", "GSM2529083", "GSM2529084", "GSM2529085", "GSM2529086", "GSM2529087", "GSM2529088", "GSM2529089", "GSM2529090", "GSM2529091", "GSM2529092", "GSM2529093", "GSM2529094", "GSM2529095", "GSM2529096", "GSM2529097", "GSM2529098", "GSM2529099", "GSM2529100", "GSM2529101", "GSM2529102", "GSM2529103", "GSM2529104", "GSM2529105", "GSM2529106", "GSM2529107", "GSM2529108", "GSM2529109", "GSM2529110", "GSM2529111", "GSM2529112", "GSM2529113", "GSM2529114", "GSM2529115", "GSM2529116", "GSM2529117", "GSM2529118", "GSM2529119", "GSM2529120", "GSM2529121", "GSM2529122", "GSM2529123", "GSM2529124", "GSM2529125", "GSM2529126", "GSM2529127", "GSM2529128", "GSM2529129", "GSM2529130", "GSM2529131", "GSM2529132", "GSM2529133", "GSM2529134", "GSM2529135", "GSM2529136", "GSM2529137", "GSM2529138", "GSM2529139", "GSM2529140", "GSM2529141", "GSM2529142", "GSM2529143", "GSM2529144", "GSM2529145", "GSM2529146", "GSM2529147", "GSM2529148", "GSM2529149", "GSM2529150", "GSM2529151", "GSM2529152", "GSM2529153", "GSM2529154", "GSM2529155", "GSM2529156", "GSM2529157", "GSM2529158", "GSM2529159", "GSM2529160", "GSM2529161", "GSM2529162", "GSM2529163", "GSM2529164", "GSM2529165", "GSM2529166", "GSM2529167", "GSM2529168", "GSM2529169", "GSM2529170", "GSM2529171", "GSM2529172", "GSM2529173", "GSM2529174", "GSM2529175", "GSM2529176", "GSM2529177", "GSM2529178", "GSM2529179", "GSM2529180", "GSM2529181", "GSM2529182", "GSM2529183", "GSM2529184", "GSM2529185", "GSM2529186", "GSM2529187", "GSM2529188", "GSM2529189", "GSM2529190", "GSM2529191", "GSM2529192", "GSM2529193", "GSM2529194", "GSM2529195", "GSM2529196", "GSM2529197", "GSM2529198", "GSM2529199", "GSM2529200", "GSM2529201", "GSM2529202", "GSM2529203", "GSM2529204", "GSM2529205", "GSM2529206", "GSM2529207", "GSM2529208", "GSM2529209", "GSM2529210", "GSM2529211", "GSM2529212", "GSM2529213", "GSM2529214", "GSM2529215", "GSM2529216", "GSM2529217", "GSM2529218", "GSM2529219", "GSM2529220", "GSM2529221", "GSM2529222", "GSM2529223", "GSM2529224", "GSM2529225", "GSM2529226", "GSM2529227", "GSM2529228", "GSM2529229", "GSM2529230", "GSM2529231", "GSM2529232", "GSM2529233", "GSM2529234", "GSM2529235", "GSM2529236", "GSM2529237", "GSM2529238", "GSM2529239", "GSM2529240", "GSM2529241", "GSM2529242", "GSM2529243", "GSM2529244", "GSM2529245", "GSM2529246", "GSM2529247", "GSM2529248", "GSM2529249", "GSM2529250", "GSM2529251", "GSM2529252", "GSM2529253", "GSM2529254", "GSM2529255", "GSM2529256", "GSM2529257", "GSM2529258", "GSM2529259", "GSM2529260", "GSM2529261", "GSM2529262", "GSM2529263", "GSM2529264", "GSM2529265", "GSM2529266", "GSM2529267", "GSM2529268", "GSM2529269", "GSM2529270", "GSM2529271", "GSM2529272", "GSM2529273", "GSM2529274", "GSM2529275", "GSM2529276", "GSM2529277", "GSM2529278", "GSM2529279", "GSM2529280", "GSM2529281", "GSM2529282", "GSM2529283", "GSM2529284", "GSM2529285", "GSM2529286", "GSM2529287", "GSM2529288", "GSM2529289", "GSM2529290", "GSM2529291", "GSM2529292", "GSM2529293", "GSM2529294", "GSM2529295", "GSM2529296", "GSM2529297", "GSM2529298", "GSM2529299", "GSM2529300", "GSM2529301", "GSM2529302", "GSM2529303", "GSM2529304", "GSM2529305", "GSM2529306", "GSM2529307", "GSM2529308", "GSM2529309", "GSM2529310", "GSM2529311", "GSM2529312", "GSM2529313", "GSM2529314", "GSM2529315", "GSM2529316", "GSM2529317", "GSM2529318", "GSM2529319", "GSM2529320", "GSM2529321", "GSM2529322", "GSM2529323", "GSM2529324", "GSM2529325", "GSM2529326", "GSM2529327", "GSM2529328", "GSM2529329", "GSM2529330", "GSM2529331", "GSM2529332", "GSM2529333", "GSM2529334", "GSM2529335", "GSM2529336", "GSM2529337", "GSM2529338", "GSM2529339", "GSM2529340", "GSM2529341", "GSM2529342", "GSM2529343", "GSM2529344", "GSM2529345", "GSM2529346", "GSM2529347", "GSM2529348", "GSM2529349", "GSM2529350", "GSM2529351", "GSM2529352", "GSM2529353", "GSM2529354", "GSM2529355", "GSM2529356", "GSM2529357", "GSM2529358", "GSM2529359", "GSM2529360", "GSM2529361", "GSM2529362", "GSM2529363", "GSM2529364", "GSM2529365", "GSM2529366", "GSM2529367", "GSM2529368", "GSM2529369", "GSM2529370", "GSM2529371", "GSM2529372", "GSM2529373", "GSM2529374", "GSM2529375", "GSM2529376", "GSM2529377", "GSM2529378", "GSM2529379", "GSM2529380", "GSM2529381", "GSM2529382", "GSM2529383", "GSM2529384", "GSM2529385", "GSM2529386", "GSM2529387", "GSM2529388", "GSM2529389", "GSM2529390", "GSM2529391", "GSM2529392", "GSM2529393", "GSM2529394", "GSM2529395", "GSM2529396", "GSM2529397", "GSM2529398", "GSM2529399", "GSM2529400", "GSM2529401", "GSM2529402", "GSM2529403", "GSM2529404", "GSM2529405", "GSM2529406", "GSM2529407", "GSM2529408", "GSM2529409", "GSM2529410", "GSM2529411", "GSM2529412", "GSM2529413", "GSM2529414", "GSM2529415", "GSM2529416", "GSM2529417", "GSM2529418", "GSM2529419", "GSM2529420", "GSM2529421", "GSM2529422", "GSM2529423", "GSM2529424", "GSM2529425", "GSM2529426", "GSM2529427", "GSM2529428", "GSM2529429", "GSM2529430", "GSM2529431", "GSM2529432", "GSM2529433", "GSM2529434", "GSM2529435", "GSM2529436", "GSM2529437", "GSM2529438", "GSM2529439", "GSM2529440", "GSM2529441", "GSM2529442", "GSM2529443", "GSM2529444", "GSM2529445", "GSM2529446", "GSM2529447", "GSM2529448", "GSM2529449", "GSM2529450", "GSM2529451", "GSM2529452", "GSM2529453", "GSM2529454", "GSM2529455", "GSM2529456", "GSM2529457", "GSM2529458", "GSM2529459", "GSM2529460", "GSM2529461", "GSM2529462", "GSM2529463", "GSM2529464", "GSM2529465", "GSM2529466", "GSM2529467", "GSM2529468", "GSM2529469", "GSM2529470", "GSM2529471", "GSM2529472", "GSM2529473", "GSM2529474", "GSM2529475", "GSM2529476", "GSM2529477", "GSM2529478", "GSM2529479", "GSM2529480", "GSM2529481", "GSM2529482", "GSM2529483", "GSM2529484", "GSM2529485", "GSM2529486", "GSM2529487", "GSM2529488", "GSM2529489", "GSM2529490", "GSM2529491", "GSM2529492", "GSM2529493", "GSM2529494", "GSM2529495", "GSM2529496", "GSM2529497", "GSM2529498", "GSM2529499", "GSM2529500", "GSM2529501", "GSM2529502", "GSM2529503", "GSM2529504", "GSM2529505", "GSM2529506", "GSM2529507", "GSM2529508", "GSM2529509", "GSM2529510", "GSM2529511", "GSM2529512", "GSM2529513", "GSM2529514", "GSM2529515", "GSM2529516", "GSM2529517", "GSM2529518", "GSM2529519", "GSM2529520", "GSM2529521", "GSM2529522", "GSM2529523", "GSM2529524", "GSM2529525", "GSM2529526", "GSM2529527", "GSM2529528", "GSM2529529", "GSM2529530", "GSM2529531", "GSM2529532", "GSM2529533", "GSM2529534", "GSM2529535", "GSM2529536", "GSM2529537", "GSM2529538", "GSM2529539", "GSM2529540", "GSM2529541", "GSM2529542", "GSM2529543", "GSM2529544", "GSM2529545", "GSM2529546", "GSM2529547", "GSM2529548", "GSM2529549", "GSM2529550", "GSM2529551", "GSM2529552", "GSM2529553", "GSM2529554", "GSM2529555", "GSM2529556", "GSM2529557", "GSM2529558", "GSM2529559", "GSM2529560", "GSM2529561", "GSM2529562", "GSM2529563", "GSM2529564", "GSM2529565", "GSM2529566", "GSM2529567", "GSM2529568", "GSM2529569", "GSM2529570", "GSM2529571", "GSM2529572", "GSM2529573", "GSM2529574", "GSM2529575", "GSM2529576", "GSM2529577", "GSM2529578", "GSM2529579", "GSM2529580", "GSM2529581", "GSM2529582", "GSM2529583", "GSM2529584", "GSM2529585", "GSM2529586", "GSM2529587", "GSM2529588", "GSM2529589", "GSM2529590", "GSM2529591", "GSM2529592", "GSM2529593", "GSM2529594", "GSM2529595", "GSM2529596", "GSM2529597", "GSM2529598", "GSM2529599", "GSM2529600", "GSM2529601", "GSM2529602", "GSM2529603", "GSM2529604", "GSM2529605", "GSM2529606", "GSM2529607", "GSM2529608", "GSM2529609", "GSM2529610", "GSM2529611", "GSM2529612", "GSM2529613", "GSM2529614", "GSM2529615", "GSM2529616", "GSM2529617", "GSM2529618", "GSM2529619", "GSM2529620", "GSM2529621", "GSM2529622", "GSM2529623", "GSM2529624", "GSM2529625", "GSM2529626", "GSM2529627", "GSM2529628", "GSM2529629", "GSM2529630", "GSM2529631", "GSM2529632", "GSM2529633", "GSM2529634", "GSM2529635", "GSM2529636", "GSM2529637", "GSM2529638", "GSM2529639", "GSM2529640", "GSM2529641", "GSM2529642", "GSM2529643", "GSM2529644", "GSM2529645", "GSM2529646", "GSM2529647", "GSM2529648", "GSM2529649", "GSM2529650", "GSM2529651", "GSM2529652", "GSM2529653", "GSM2529654", "GSM2529655", "GSM2529656", "GSM2529657", "GSM2529658", "GSM2529659", "GSM2529660", "GSM2529661", "GSM2529662", "GSM2529663", "GSM2529664", "GSM2529665", "GSM2529666", "GSM2529667", "GSM2529668", "GSM2529669", "GSM2529670", "GSM2529671", "GSM2529672", "GSM2529673", "GSM2529674", "GSM2529675", "GSM2529676", "GSM2529677", "GSM2529678", "GSM2529679", "GSM2529680", "GSM2529681", "GSM2529682", "GSM2529683", "GSM2529684", "GSM2529685", "GSM2529686", "GSM2529687", "GSM2529688", "GSM2529689", "GSM2529690", "GSM2529691", "GSM2529692", "GSM2529693", "GSM2529694", "GSM2529695", "GSM2529696", "GSM2529697", "GSM2529698", "GSM2529699", "GSM2529700", "GSM2529701", "GSM2529702", "GSM2529703", "GSM2529704", "GSM2529705", "GSM2529706", "GSM2529707", "GSM2529708", "GSM2529709", "GSM2529710", "GSM2529711", "GSM2529712", "GSM2529713", "GSM2529714", "GSM2529715", "GSM2529716", "GSM2529717", "GSM2529718", "GSM2529719", "GSM2529720", "GSM2529721", "GSM2529722", "GSM2529723", "GSM2529724", "GSM2529725", "GSM2529726", "GSM2529727", "GSM2529728", "GSM2529729", "GSM2529730", "GSM2529731", "GSM2529732", "GSM2529733", "GSM2529734", "GSM2529735", "GSM2529736", "GSM2529737", "GSM2529738", "GSM2529739", "GSM2529740", "GSM2529741", "GSM2529742", "GSM2529743", "GSM2529744", "GSM2529745", "GSM2529746", "GSM2529747", "GSM2529748", "GSM2529749", "GSM2529750", "GSM2529751", "GSM2529752", "GSM2529753", "GSM2529754", "GSM2529755", "GSM2529756", "GSM2529757", "GSM2529758", "GSM2529759", "GSM2529760", "GSM2529761", "GSM2529762", "GSM2529763", "GSM2529764", "GSM2529765", "GSM2529766", "GSM2529767", "GSM2529768", "GSM2529769", "GSM2529770", "GSM2529771", "GSM2529772", "GSM2529773", "GSM2529774", "GSM2529775", "GSM2529776", "GSM2529777", "GSM2529778", "GSM2529779", "GSM2529780", "GSM2529781", "GSM2529782", "GSM2529783", "GSM2529784", "GSM2529785", "GSM2529786", "GSM2529787", "GSM2529788", "GSM2529789", "GSM2529790", "GSM2529791", "GSM2529792", "GSM2529793", "GSM2529794", "GSM2529795", "GSM2529796", "GSM2529797", "GSM2529798", "GSM2529799", "GSM2529800", "GSM2529801", "GSM2529802", "GSM2529803", "GSM2529804", "GSM2529805", "GSM2529806", "GSM2529807", "GSM2529808", "GSM2529809", "GSM2529810", "GSM2529811", "GSM2529812", "GSM2529813", "GSM2529814", "GSM2529815", "GSM2529816", "GSM2529817", "GSM2529818", "GSM2529819", "GSM2529820", "GSM2529821", "GSM2529822", "GSM2529823", "GSM2529824", "GSM2529825", "GSM2529826", "GSM2529827", "GSM2529828", "GSM2529829", "GSM2529830", "GSM2529831", "GSM2529832", "GSM2529833", "GSM2529834", "GSM2529835", "GSM2529836", "GSM2529837", "GSM2529838", "GSM2529839", "GSM2529840", "GSM2529841", "GSM2529842", "GSM2529843", "GSM2529844", "GSM2529845", "GSM2529846", "GSM2529847", "GSM2529848", "GSM2529849", "GSM2529850", "GSM2529851", "GSM2529852", "GSM2529853", "GSM2529854", "GSM2529855", "GSM2529856", "GSM2529857", "GSM2529858", "GSM2529859", "GSM2529860", "GSM2529861", "GSM2529862", "GSM2529863", "GSM2529864", "GSM2529865", "GSM2529866", "GSM2529867", "GSM2529868", "GSM2529869", "GSM2529870", "GSM2529871", "GSM2529872", "GSM2529873", "GSM2529874", "GSM2529875", "GSM2529876", "GSM2529877", "GSM2529878", "GSM2529879", "GSM2529880", "GSM2529881", "GSM2529882", "GSM2529883", "GSM2529884", "GSM2529885", "GSM2529886", "GSM2529887", "GSM2529888", "GSM2529889", "GSM2529890", "GSM2529891", "GSM2529892", "GSM2529893", "GSM2529894", "GSM2529895", "GSM2529896", "GSM2529897", "GSM2529898", "GSM2529899", "GSM2529900", "GSM2529901", "GSM2529902", "GSM2529903", "GSM2529904", "GSM2529905", "GSM2529906", "GSM2529907", "GSM2529908", "GSM2529909", "GSM2529910", "GSM2529911", "GSM2529912", "GSM2529913", "GSM2529914", "GSM2529915", "GSM2529916", "GSM2529917", "GSM2529918", "GSM2529919", "GSM2529920", "GSM2529921", "GSM2529922", "GSM2529923", "GSM2529924", "GSM2529925", "GSM2529926", "GSM2529927", "GSM2529928", "GSM2529929", "GSM2529930", "GSM2529931", "GSM2529932", "GSM2529933", "GSM2529934", "GSM2529935", "GSM2529936", "GSM2529937", "GSM2529938", "GSM2529939", "GSM2529940", "GSM2529941", "GSM2529942", "GSM2529943", "GSM2529944", "GSM2529945", "GSM2529946", "GSM2529947", "GSM2529948", "GSM2529949", "GSM2529950", "GSM2529951", "GSM2529952", "GSM2529953", "GSM2529954", "GSM2529955", "GSM2529956", "GSM2529957", "GSM2529958", "GSM2529959", "GSM2529960", "GSM2529961", "GSM2529962", "GSM2529963", "GSM2529964", "GSM2529965", "GSM2529966", "GSM2529967", "GSM2529968", "GSM2529969", "GSM2529970", "GSM2529971", "GSM2529972", "GSM2529973", "GSM2529974", "GSM2529975", "GSM2529976", "GSM2529977", "GSM2529978", "GSM2529979", "GSM2529980", "GSM2529981", "GSM2529982", "GSM2529983", "GSM2529984", "GSM2529985", "GSM2529986", "GSM2529987", "GSM2529988", "GSM2529989", "GSM2529990", "GSM2529991", "GSM2529992", "GSM2529993", "GSM2529994", "GSM2529995", "GSM2529996", "GSM2529997", "GSM2529998", "GSM2529999", "GSM2530000", "GSM2530001", "GSM2530002", "GSM2530003", "GSM2530004", "GSM2530005", "GSM2530006", "GSM2530007", "GSM2530008", "GSM2530009", "GSM2530010", "GSM2530011", "GSM2530012", "GSM2530013", "GSM2530014", "GSM2530015", "GSM2530016", "GSM2530017", "GSM2530018", "GSM2530019", "GSM2530020", "GSM2530021", "GSM2530022", "GSM2530023", "GSM2530024", "GSM2530025", "GSM2530026", "GSM2530027", "GSM2530028", "GSM2530029", "GSM2530030", "GSM2530031", "GSM2530032", "GSM2530033", "GSM2530034", "GSM2530035", "GSM2530036", "GSM2530037", "GSM2530038", "GSM2530039", "GSM2530040", "GSM2530041", "GSM2530042", "GSM2530043", "GSM2530044", "GSM2530045", "GSM2530046", "GSM2530047", "GSM2530048", "GSM2530049", "GSM2530050", "GSM2530051", "GSM2530052", "GSM2530053", "GSM2530054", "GSM2530055", "GSM2530056", "GSM2530057", "GSM2530058", "GSM2530059", "GSM2530060", "GSM2530061", "GSM2530062", "GSM2530063", "GSM2530064", "GSM2530065", "GSM2530066", "GSM2530067", "GSM2530068", "GSM2530069", "GSM2530070", "GSM2530071", "GSM2530072", "GSM2530073", "GSM2530074", "GSM2530075", "GSM2530076", "GSM2530077", "GSM2530078", "GSM2530079", "GSM2530080", "GSM2530081", "GSM2530082", "GSM2530083", "GSM2530084", "GSM2530085", "GSM2530086", "GSM2530087", "GSM2530088", "GSM2530089", "GSM2530090", "GSM2530091", "GSM2530092", "GSM2530093", "GSM2530094", "GSM2530095", "GSM2530096", "GSM2530097", "GSM2530098", "GSM2530099", "GSM2530100", "GSM2530101", "GSM2530102", "GSM2530103", "GSM2530104", "GSM2530105", "GSM2530106", "GSM2530107", "GSM2530108", "GSM2530109", "GSM2530110", "GSM2530111", "GSM2530112", "GSM2530113", "GSM2530114", "GSM2530115", "GSM2530116", "GSM2530117", "GSM2530118", "GSM2530119", "GSM2530120", "GSM2530121", "GSM2530122", "GSM2530123", "GSM2530124", "GSM2530125", "GSM2530126", "GSM2530127", "GSM2530128", "GSM2530129", "GSM2530130", "GSM2530131", "GSM2530132", "GSM2530133", "GSM2530134", "GSM2530135", "GSM2530136", "GSM2530137", "GSM2530138", "GSM2530139", "GSM2530140", "GSM2530141", "GSM2530142", "GSM2530143", "GSM2530144", "GSM2530145", "GSM2530146", "GSM2530147", "GSM2530148", "GSM2530149", "GSM2530150", "GSM2530151", "GSM2530152", "GSM2530153", "GSM2530154", "GSM2530155", "GSM2530156", "GSM2530157", "GSM2530158", "GSM2530159", "GSM2530160", "GSM2530161", "GSM2530162", "GSM2530163", "GSM2530164", "GSM2530165", "GSM2530166", "GSM2530167", "GSM2530168", "GSM2530169", "GSM2530170", "GSM2530171", "GSM2530172", "GSM2530173", "GSM2530174", "GSM2530175", "GSM2530176", "GSM2530177", "GSM2530178", "GSM2530179", "GSM2530180", "GSM2530181", "GSM2530182", "GSM2530183", "GSM2530184", "GSM2530185", "GSM2530186", "GSM2530187", "GSM2530188", "GSM2530189", "GSM2530190", "GSM2530191", "GSM2530192", "GSM2530193", "GSM2530194", "GSM2530195", "GSM2530196", "GSM2530197", "GSM2530198", "GSM2530199", "GSM2530200", "GSM2530201", "GSM2530202", "GSM2530203", "GSM2530204", "GSM2530205", "GSM2530206", "GSM2530207", "GSM2530208", "GSM2530209", "GSM2530210", "GSM2530211", "GSM2530212", "GSM2530213", "GSM2530214", "GSM2530215", "GSM2530216", "GSM2530217", "GSM2530218", "GSM2530219", "GSM2530220", "GSM2530221", "GSM2530222", "GSM2530223", "GSM2530224", "GSM2530225", "GSM2530226", "GSM2530227", "GSM2530228", "GSM2530229", "GSM2530230", "GSM2530231", "GSM2530232", "GSM2530233", "GSM2530234", "GSM2530235", "GSM2530236", "GSM2530237", "GSM2530238", "GSM2530239", "GSM2530240", "GSM2530241", "GSM2530242", "GSM2530243", "GSM2530244", "GSM2530245", "GSM2530246", "GSM2530247", "GSM2530248", "GSM2530249", "GSM2530250", "GSM2530251", "GSM2530252", "GSM2530253", "GSM2530254", "GSM2530255", "GSM2530256", "GSM2530257", "GSM2530258", "GSM2530259", "GSM2530260", "GSM2530261", "GSM2530262", "GSM2530263", "GSM2530264", "GSM2530265", "GSM2530266", "GSM2530267", "GSM2530268", "GSM2530269", "GSM2530270", "GSM2530271", "GSM2530272", "GSM2530273", "GSM2530274", "GSM2530275", "GSM2530276", "GSM2530277", "GSM2530278", "GSM2530279", "GSM2530280", "GSM2530281", "GSM2530282", "GSM2530283", "GSM2530284", "GSM2530285", "GSM2530286", "GSM2530287", "GSM2530288", "GSM2530289", "GSM2530290", "GSM2530291", "GSM2530292", "GSM2530293", "GSM2530294", "GSM2530295", "GSM2530296", "GSM2530297", "GSM2530298", "GSM2530299", "GSM2530300", "GSM2530301", "GSM2530302", "GSM2530303", "GSM2530304", "GSM2530305", "GSM2530306", "GSM2530307", "GSM2530308", "GSM2530309", "GSM2530310", "GSM2530311", "GSM2530312", "GSM2530313", "GSM2530314", "GSM2530315", "GSM2530316", "GSM2530317", "GSM2530318", "GSM2530319", "GSM2530320", "GSM2530321", "GSM2530322", "GSM2530323", "GSM2530324", "GSM2530325", "GSM2530326", "GSM2530327", "GSM2530328", "GSM2530329", "GSM2530330", "GSM2530331", "GSM2530332", "GSM2530333", "GSM2530334", "GSM2530335", "GSM2530336", "GSM2530337", "GSM2530338", "GSM2530339", "GSM2530340", "GSM2530341", "GSM2530342", "GSM2530343", "GSM2530344", "GSM2530345", "GSM2530346", "GSM2530347", "GSM2530348", "GSM2530349", "GSM2530350", "GSM2530351", "GSM2530352", "GSM2530353", "GSM2530354", "GSM2530355", "GSM2530356", "GSM2530357", "GSM2530358", "GSM2530359", "GSM2530360", "GSM2530361", "GSM2530362", "GSM2530363", "GSM2530364", "GSM2530365", "GSM2530366", "GSM2530367", "GSM2530368", "GSM2530369", "GSM2530370", "GSM2530371", "GSM2530372", "GSM2530373", "GSM2530374", "GSM2530375", "GSM2530376", "GSM2530377", "GSM2530378", "GSM2530379", "GSM2530380", "GSM2530381", "GSM2530382", "GSM2530383", "GSM2530384", "GSM2530385", "GSM2530386", "GSM2530387", "GSM2530388", "GSM2530389", "GSM2530390", "GSM2530391", "GSM2530392", "GSM2530393", "GSM2530394", "GSM2530395", "GSM2530396", "GSM2530397", "GSM2530398", "GSM2530399", "GSM2530400", "GSM2530401", "GSM2530402", "GSM2530403", "GSM2530404", "GSM2530405", "GSM2530406", "GSM2530407", "GSM2530408", "GSM2530409", "GSM2530410", "GSM2530411", "GSM2530412", "GSM2530413", "GSM2530414", "GSM2530415", "GSM2530416", "GSM2530417", "GSM2530418", "GSM2530419", "GSM2530420", "GSM2530421", "GSM2530422", "GSM2530423", "GSM2530424", "GSM2530425", "GSM2530426", "GSM2530427", "GSM2530428", "GSM2530429", "GSM2530430", "GSM2530431", "GSM2530432", "GSM2530433", "GSM2530434", "GSM2530435", "GSM2530436", "GSM2530437", "GSM2530438", "GSM2530439", "GSM2530440", "GSM2530441", "GSM2530442", "GSM2530443", "GSM2530444", "GSM2530445", "GSM2530446", "GSM2530447", "GSM2530448", "GSM2530449", "GSM2530450", "GSM2530451", "GSM2530452", "GSM2530453", "GSM2530454", "GSM2530455", "GSM2530456", "GSM2530457", "GSM2530458", "GSM2530459", "GSM2530460", "GSM2530461", "GSM2530462", "GSM2530463", "GSM2530464", "GSM2530465", "GSM2530466", "GSM2530467", "GSM2530468", "GSM2530469", "GSM2530470", "GSM2530471", "GSM2530472", "GSM2530473", "GSM2530474", "GSM2530475", "GSM2530476", "GSM2530477", "GSM2530478", "GSM2530479", "GSM2530480", "GSM2530481", "GSM2530482", "GSM2530483", "GSM2530484", "GSM2530485", "GSM2530486", "GSM2530487", "GSM2530488", "GSM2530489", "GSM2530490", "GSM2530491", "GSM2530492", "GSM2530493", "GSM2530494", "GSM2530495", "GSM2530496", "GSM2530497", "GSM2530498", "GSM2530499", "GSM2530500", "GSM2530501", "GSM2530502", "GSM2530503", "GSM2530504", "GSM2530505", "GSM2530506", "GSM2530507", "GSM2530508", "GSM2530509", "GSM2530510", "GSM2530511", "GSM2530512", "GSM2530513", "GSM2530514", "GSM2530515", "GSM2530516", "GSM2530517", "GSM2530518", "GSM2530519", "GSM2530520", "GSM2530521", "GSM2530522", "GSM2530523", "GSM2530524", "GSM2530525", "GSM2530526", "GSM2530527", "GSM2530528", "GSM2530529", "GSM2530530", "GSM2530531", "GSM2530532", "GSM2530533", "GSM2530534", "GSM2530535", "GSM2530536", "GSM2530537", "GSM2530538", "GSM2530539", "GSM2530540", "GSM2530541", "GSM2530542", "GSM2530543", "GSM2530544", "GSM2530545", "GSM2530546", "GSM2530547", "GSM2530548", "GSM2530549", "GSM2530550", "GSM2530551", "GSM2530552", "GSM2530553", "GSM2530554", "GSM2530555", "GSM2530556", "GSM2530557", "GSM2530558", "GSM2530559", "GSM2530560", "GSM2530561", "GSM2530562", "GSM2530563", "GSM2530564", "GSM2530565", "GSM2530566", "GSM2530567", "GSM2530568", "GSM2530569", "GSM2530570", "GSM2530571", "GSM2530572", "GSM2530573", "GSM2530574", "GSM2530575", "GSM2530576", "GSM2530577", "GSM2530578", "GSM2530579", "GSM2530580", "GSM2530581", "GSM2530582", "GSM2530583", "GSM2530584", "GSM2530585", "GSM2530586", "GSM2530587", "GSM2530588", "GSM2530589", "GSM2530590", "GSM2530591", "GSM2530592", "GSM2530593", "GSM2530594", "GSM2530595", "GSM2530596", "GSM2530597", "GSM2530598", "GSM2530599", "GSM2530600", "GSM2530601", "GSM2530602", "GSM2530603", "GSM2530604", "GSM2530605", "GSM2530606", "GSM2530607", "GSM2530608", "GSM2530609", "GSM2530610", "GSM2530611", "GSM2530612", "GSM2530613", "GSM2530614", "GSM2530615", "GSM2530616", "GSM2530617", "GSM2530618", "GSM2530619", "GSM2530620", "GSM2530621", "GSM2530622", "GSM2530623", "GSM2530624", "GSM2530625", "GSM2530626", "GSM2530627", "GSM2530628", "GSM2530629", "GSM2530630", "GSM2530631", "GSM2530632", "GSM2530633", "GSM2530634", "GSM2530635", "GSM2530636", "GSM2530637", "GSM2530638", "GSM2530639", "GSM2530640", "GSM2530641", "GSM2530642", "GSM2530643", "GSM2530644", "GSM2530645", "GSM2530646", "GSM2530647", "GSM2530648", "GSM2530649", "GSM2530650", "GSM2530651", "GSM2530652", "GSM2530653", "GSM2530654", "GSM2530655", "GSM2530656", "GSM2530657", "GSM2530658", "GSM2530659", "GSM2530660", "GSM2530661", "GSM2530662", "GSM2530663", "GSM2530664", "GSM2530665", "GSM2530666", "GSM2530667", "GSM2530668", "GSM2530669", "GSM2530670", "GSM2530671", "GSM2530672", "GSM2530673", "GSM2530674", "GSM2530675", "GSM2530676", "GSM2530677", "GSM2530678", "GSM2530679", "GSM2530680", "GSM2530681", "GSM2530682", "GSM2530683", "GSM2530684", "GSM2530685", "GSM2530686", "GSM2530687", "GSM2530688", "GSM2530689", "GSM2530690", "GSM2530691", "GSM2530692", "GSM2530693", "GSM2530694", "GSM2530695", "GSM2530696", "GSM2530697", "GSM2530698", "GSM2530699", "GSM2530700", "GSM2530701", "GSM2530702", "GSM2530703", "GSM2530704", "GSM2530705", "GSM2530706", "GSM2530707", "GSM2530708", "GSM2530709", "GSM2530710", "GSM2530711", "GSM2530712", "GSM2530713", "GSM2530714", "GSM2530715", "GSM2530716", "GSM2530717", "GSM2530718", "GSM2530719", "GSM2530720", "GSM2530721", "GSM2530722", "GSM2530723", "GSM2530724", "GSM2530725", "GSM2530726", "GSM2530727", "GSM2530728", "GSM2530729", "GSM2530730", "GSM2530731", "GSM2530732", "GSM2530733", "GSM2530734", "GSM2530735", "GSM2530736", "GSM2530737", "GSM2530738", "GSM2530739", "GSM2530740", "GSM2530741", "GSM2530742", "GSM2530743", "GSM2530744", "GSM2530745", "GSM2530746", "GSM2530747", "GSM2530748", "GSM2530749", "GSM2530750", "GSM2530751", "GSM2530752", "GSM2530753", "GSM2530754", "GSM2530755", "GSM2530756", "GSM2530757", "GSM2530758", "GSM2530759", "GSM2530760", "GSM2530761", "GSM2530762", "GSM2530763", "GSM2530764", "GSM2530765", "GSM2530766", 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"missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["time_to_event_with_censoring"], "evidence": {"score": 1.0, "band": "verbatim", "quote": "A risk signature was established through univariate and multivariate Cox regression analyses."}}, {"id": "method-2", "family": "survival_analysis", "specific": "kaplan_meier", "label": "Survival analysis", "dsl_operations": ["survival_km"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["time_to_event_with_censoring"], "evidence": {"score": 0.8, "band": "high", "quote": "Kaplan-Meier"}}], "targets": [], "gaps": []}, "capability": {"state": "complete", "requirements": [{"capability_id": "capability:computational_analysis", "label": "Computational analysis platform", "assay_families": ["meta_analysis", "machine_learning", "survival_analysis", "statistical_regression", "pca", "molecular_docking", "network_analysis", "differential_expression", "gwas"], "availability_state": "owned", "tier_unlocked": "R1", "candidate": "Automated Assays Laravel application and simulated adapters"}], "gaps": []}, "readiness": {"state": "complete", "tier": "R1", "blocking_axis": "none", "blocked_on": "nothing:replicable_now", "axes": {"method": {"tier": "R1", "expressible": true, "required_operations": ["cox_ph"], "missing_operations": [], "basis": "The paper names the method it used and the corpus's method extractor maps it onto the DSL catalogue: cox_proportional_hazards."}, "capability": {"tier": "R1", "capability_id": "capability:computational_analysis", "availability_state": "owned", "basis": "The computational analysis is owned. The physical bench the paper used is not, so a physical validation cannot be run here."}, "data": {"tier": "R1", "reachable": true, "accessions": ["GSE96058"], "resolved_accessions": ["GSE96058"], "statements": ["The original contributions presented in the study are included in the article/ Supplementary Material . Further inquiries can be directed to the corresponding author."], "basis": "The paper names GSE96058 in GEO database and the accession resolves in the repository. No dataset was downloaded and no licence was read."}}, "can_run": {"dsl_operations": ["cox_ph"], "assets": ["source:pmid:35619902", "data:geo:GSE96058"], "steps": ["run_analysis"]}, "must_build": {"dsl_operations": [], "converters": [], "readers": [], "capabilities": [], "data_gaps": ["data:geo:GSE96058"]}, "gaps": []}, "review": {"state": "partial", "machine_critique": {"kind": "extraction_review", "reader": {"model": "MiniMax-M3.1-Flash", "provider": "minimax", "provider_family": "minimax", "read_at": "2026-11-01T17:47:31Z", "independence": "single_reader"}, "evidence_check": {"method": "verbatim", "availability": "verbatim"}, "calls": 5, "usage": {"prompt_tokens": 13644, "completion_tokens": 1346, "cached_tokens": 128}}, "human_critique": null, "stages": [{"id": "extraction", "state": "complete", "reader": "MiniMax-M3.1-Flash", "provider": "minimax"}], "gaps": ["review.independent_reader", "review.machine_critique", "review.human_critique"]}, "execution": {"state": "absent", "status": "not_run", "mode": null, "runs": [], "gaps": ["execution.not_run"]}, "provenance": {"entities": [{"id": "pmid:35619902", "type": "paper", "label": "pmid:35619902"}, {"id": "source:pmid:35619902", "type": "manuscript", "label": "PMID 35619902 full text"}, {"id": "data:geo:GSE96058", "type": "dataset", "label": "GEO GSE96058"}], "activities": [{"id": "activity-reading-sci-2026-11-01", "type": "classification", "used": [{"id": "pmid:35619902", "type": "paper", "label": "pmid:35619902"}, {"id": "source:pmid:35619902", "type": "manuscript", "label": "PMID 35619902 full text"}, {"id": "data:geo:GSE96058", "type": "dataset", "label": "GEO GSE96058"}], "agent": "agent:corpus-assay-engine"}, {"id": "activity-read-35619902", "type": "extraction", "used": ["source:pmid:35619902"], "agent": "agent:minimax-reader"}, {"id": "activity-resolve-GSE96058", "type": "accession_resolution", "used": ["data:geo:GSE96058"], "agent": "agent:corpus-assay-engine"}], "agents": [{"id": "agent:corpus-assay-engine", "type": "software", "label": "Corpus assay engine"}, {"id": "agent:minimax-reader", "type": "software", "label": "MiniMax literature reader"}], "source_run_id": "reading-sci-2026-11-01", "dsl_catalogue_fingerprint": "343fb30756ba6ec3", "capability_table_fingerprint": "2cb3e42f047d2ecf", "snapshot_id": "ba34b49490d9bfaf"}, "lineage": {"parent_id": "pmid:35619902", "parent_hash": "sha256:6215c6430ea23f446b0e213ccc159e96072c1cd65885bc0edbe2a1d02012f9cf", "fork_of": null, "generation": 2}, "gaps": ["asset:data:geo:GSE96058 licence not read", "asset:data:geo:GSE96058 not downloaded", "execution.not_run", "review.human_critique", "review.independent_reader", "review.machine_critique"], "assays": [{"role": "data_generation", "definition_id": "cell_culture", "definition_version": "99e1195c7d6f", "definition_digest": null, "required_operations": [], "support_state": "partial", "source_hashes": {"assay_lexicon": "99e1195c7d6f"}, "confidence": 0.77, "evidence": ["ic database based on gene expression data of cultured human cells treated with bioactive substance"], "order_basis": "paper_text_order:2000", "id": "assay:1"}, {"role": "analysis", "definition_id": "survival_analysis", "definition_version": "f2132e96ae6c7a4e", "definition_digest": null, "required_operations": ["cox_ph"], "support_state": "supported", "source_hashes": {"dsl_catalogue": "f2132e96ae6c7a4e"}, "confidence": 1.0, "evidence": ["A risk signature was established through univariate and multivariate Cox regression analyses."], "order_basis": "consumes_earlier_output", "id": "assay:2"}]}