Data on mammary gland microRNAs expression, their predicted gene targets and corresponding pathway analysis in female mice receiving flaxseed or its oil and secoisolariciresinol diglucoside components.

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These data are in support of the article entitled \"Effects of flaxseed and its components on mammary gland miRNome: identification of potential biomarkers to prevent breast cancer development\" [1]. Here, we provide miRNA expression data obtained from NanoString nCounter® profiling of mammary gland RNA from C57BL/6 female mice who received a control diet or isocaloric diets containing 10% FS, 3.67% FSO, or 0.15% SDG for 21 days. The raw miRNA data were deposited at the NCBI Gene Expression Omnibus (GEO) database (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE193847) under the accession number GSE193847. We also identified diet-associated miRNA-gene targets and corresponding enriched pathways. These data can be found at the HARVARD Dataverse (https://doi.org/10.7910/DVN/3ZNYES). These data will be valuable as a reference to understand the effects of FS versus its components and to study responses to these ingredients in hosts of different genetic backgrounds, sex and age. These data will contribute to future investigations regarding mechanisms underlying FS effects within the mammary gland.", "claims": [{"id": "claim-data-access", "statement": "Data on mammary gland microRNA predicted gene targets and corresponding pathway analysis in female mice receiving flaxseed or its oil and secoisolariciresinol diglucoside components (Original data) (Harvard Dataverse).Mammary Gland microRNA profiling in female mice receiving flaxseed or its oil and secoisolariciresinol diglucoside components (Original data) (Gene Expression Omnibus (GEO)).", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:35677459", "locator": "sections[12] \"Data Availability\" paragraph 2", "quote": "Data on mammary gland microRNA predicted gene targets and corresponding pathway analysis in female mice receiving flaxseed or its oil and secoisolariciresinol diglucoside components (Original data) (Harvard Dataverse).Mammary Gland microRNA profiling in female mice receiving flaxseed or its oil and secoisolariciresinol diglucoside components (Original data) (Gene Expression Omnibus (GEO))."}], "state": "complete"}, {"id": "claim-target-result", "statement": "Ten miRNAs were uniquely deregulated in one of the dietary groups compared to the basal diet group.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:35677459", "locator": "sections[3] \"Data Description\" paragraph 2", "quote": "Ten miRNAs were uniquely deregulated in one of the dietary groups compared to the basal diet group as reported in [1] and for clarity they are listed here for each dietary group vs control: FS, miR-297, miR-500, miR-1, and miR-210; FSO, miR-30, miR-324-5p, miR-382, and miR-423-3p; and SDG, miR-142-5p and miR-1966."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "Ten miRNAs were uniquely deregulated in one of the dietary groups compared to the basal diet group.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:35677459"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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