Exploring the Core Genes of Schizophrenia Based on Bioinformatics Analysis.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:35741729", "kind": "science-record", "revision": 4, "content_hash": "sha256:5e0303d474b6d15b001bc08fc6b421dc4a97f1837a63d5864a5bca80fd597438", "created_at": "2026-11-01T18:14:45Z", "updated_at": "2026-11-01T22:06:51Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Exploring the Core Genes of Schizophrenia Based on Bioinformatics Analysis.", "doi": "10.3390/genes13060967", "pmid": "35741729", "authors": ["Shunkang Feng", "Ping Sun", "Chunhui Qu", "Xiaohui Wu", "Lu Yang", "Tao Yang", "Shuo Wang", "Yiru Fang", "Jun Chen"], "journal": "Genes", "year": 2022, "abstract": "Schizophrenia is a clinical syndrome composed of a group of symptoms involving many obstacles such as perception, thinking, emotion, behavior, and the disharmony of mental activities. Schizophrenia is one of the top ten causes of disability globally, accounting for about 1% of the global population. Previous studies have shown that schizophrenia has solid genetic characteristics. However, the diagnosis of schizophrenia mainly depends on symptomatic manifestations, and no gene can be used as a clear diagnostic marker at present. This study explored the hub genes of schizophrenia by bioinformatics analysis. Three datasets were selected and downloaded from the GEO database (GSE53987, GSE21138, and GSE27383). GEO2R, NCBI's online analysis tool, is used to screen out significant gene expression differences. The genes were functionally enriched by GO and KEGG enrichment analysis. On this basis, the hub genes were explored through Cytoscape software, and the immune infiltration analysis and diagnostic value of the screened hub genes were judged. Finally, four hub genes (NFKBIA, CDKN1A, BTG2, GADD45B) were screened. There was a significant correlation between two hub genes (NFKBIA, BTG2) and resting memory CD4 T cells. The ROC curve results showed that all four hub genes had diagnostic value.", "claims": [{"id": "claim-method", "statement": "An online receiver operating characteristic (ROC) curve drawing tool (https://www.xiantao.love/products, accessed on 24 May 2022) was used to help determine the diagnostic value of hub genes in schizophrenia.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:35741729", "locator": "sections[9] \"2.7. Diagnostic Value of Hub Genes\" paragraph 2", "quote": "An online receiver operating characteristic (ROC) curve drawing tool (https://www.xiantao.love/products, accessed on 24 May 2022) was used to help determine the diagnostic value of hub genes in schizophrenia."}], "state": "complete"}, {"id": "claim-data-access", "statement": "All data are obtained from public data in the GEO database.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:35741729", "locator": "sections[25] \"notes\" paragraph 1", "quote": "All data are obtained from public data in the GEO database."}], "state": "complete"}, {"id": "claim-target-result", "statement": "The four hub genes NFKBIA, CDKN1A, BTG2, and GADD45B, as well as their combined use, showed potential diagnostic value for schizophrenia, with reported AUC values of 0.60–1.00 for individual genes.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:35741729", "locator": "sections[18] \"3.8. Diagnostic Evaluation of Hub Genes\" paragraph 6", "quote": "In conclusion, four hub genes may have significant diagnostic value in the diagnosis of schizophrenia (AUC: 0.60–1.00)."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "The four hub genes NFKBIA, CDKN1A, BTG2, and GADD45B, as well as their combined use, showed potential diagnostic value for schizophrenia, with reported AUC values of 0.60–1.00 for individual genes.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:35741729"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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