Characterization of Ligand-Receptor Pair in Bladder Cancer Develops a Validated Scoring Model for Prognosis and Treatment Response.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:35784457", "kind": "science-record", "revision": 4, "content_hash": "sha256:f3d6f54254b0e302450473240acc6f451545ebb37bc4507092d3478604ee0ade", "created_at": "2026-11-01T18:14:49Z", "updated_at": "2026-11-01T22:06:55Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Characterization of Ligand-Receptor Pair in Bladder Cancer Develops a Validated Scoring Model for Prognosis and Treatment Response.", "doi": "10.3389/fcell.2022.915798", "pmid": "35784457", "authors": ["Chuang Wang", "Honglei Wan", "Han Zhang", "Bo Yang", "Wen-Kuan Huang", "Wenguo Sun"], "journal": "Frontiers in cell and developmental biology", "year": 2022, "abstract": "The role of ligand-receptor (LR) pairs in disease progression has been explored in bladder cancer. However, the relationship of LR pairs with cancer prognosis and treatment response remains poorly understood. We characterized the LR pair network and identified three distinct molecular subtypes with distinct biologic features based on the TCGA database (n = 406) and validated in GSE13507 (n = 165) and GSE32894 (n = 224). Three subtypes were compared for differences in patient clinical characteristics, genomic, and transcriptomic features. A multivariate Lasso Cox regression model was applied to construct an LR pairs-based scoring model to stratify the prognostic risk of patients. We demonstrated the high LR. score patients had better responses in chemotherapy, while low LR. score patients may benefit from immune checkpoint blockade (ICB). Collectively, we identified three LR pair-related subtypes associated with prognosis. We constructed and validated a LR pairs-based gene signature, which helps to predict prognosis and differentiate the susceptible population to chemotherapy and immunotherapy in patients with bladder cancer. Among the LR pairs significantly related to prognosis, ANAX1-EGFR axis was found to be potential therapeutic target for treatment of bladder cancer.", "claims": [{"id": "claim-method", "statement": "To test whether the LR. score could be used as an independent prognostic factor, we performed univariate and multivariate Cox regression analyses using patients’ clinical characteristics (including age, gender, TNM, Stage, Grade, etc.).", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:35784457", "locator": "sections[17] \"Clinical Characteristics of the Ligand-Receptor score\" paragraph 2", "quote": "To test whether the LR. score could be used as an independent prognostic factor, we performed univariate and multivariate Cox regression analyses using patients’ clinical characteristics (including age, gender, TNM, Stage, Grade, etc.)."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The dataset were from public TCGA and GEO datasets. The datasets presented in this study can be found in online repositories. The names of the repository/repositories and accession number(s) can be found in the article.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:35784457", "locator": "sections[21] \"Data Availability Statement\" paragraph 2", "quote": "The dataset were from public TCGA and GEO datasets. The datasets presented in this study can be found in online repositories. The names of the repository/repositories and accession number(s) can be found in the article."}], "state": "complete"}, {"id": "claim-target-result", "statement": "LR. score was a reliable and independent prognostic biomarker for bladder cancer, with HR = 2.42, 95% confidence interval 1.75–3.34, p = 8.57E-08.", "kind": "quantitative", "target": {"value": 95.0, "unit": "per cent", "tolerance": null, "source": "We found LR. score to be a reliable and independent prognostic biomarker for assessing patient prognosis (Figures 7A,B; HR = 2.42, 95% confidence interval 1.75–3.34, p = 8.57E-08)."}, "evidence": [{"asset": "source:pmid:35784457", "locator": "sections[17] \"Clinical Characteristics of the Ligand-Receptor score\" paragraph 2", "quote": "We found LR. score to be a reliable and independent prognostic biomarker for assessing patient prognosis (Figures 7A,B; HR = 2.42, 95% confidence interval 1.75–3.34, p = 8.57E-08)."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "LR. score was a reliable and independent prognostic biomarker for bladder cancer, with HR = 2.42, 95% confidence interval 1.75–3.34, p = 8.57E-08.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:35784457"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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Otherwise, the patient was assigned as “low.” The expression of LR was calculate"], "order_basis": "paper_text_order:1661", "id": "assay:1"}, {"role": "analysis", "definition_id": "survival_analysis", "definition_version": "f2132e96ae6c7a4e", "definition_digest": null, "required_operations": ["cox_ph"], "support_state": "supported", "source_hashes": {"dsl_catalogue": "f2132e96ae6c7a4e"}, "confidence": 1.0, "evidence": ["To test whether the LR. score could be used as an independent prognostic factor, we performed univariate and multivariate Cox regression analyses using patients’ clinical characteristics (including age, gender, TNM, Stage, Grade, etc.)."], "order_basis": "consumes_earlier_output", "id": "assay:2"}]}