Pan-Cancer Analysis Predicts the Immunological and Prognostic Role of ZC3H12C in KIRC.

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Through comparative analysis of the Cancer Genome Atlas (TCGA) database, we found that ZC3H12C is the most relevant to the prognosis, grade, and stage of renal clear cell carcinoma (ccRCC) across 33 cancers. With the help of patient transcription and clinical data from the TCGA and GEO (GSE53757, GSE36895) databases, we determined that in the immune environment of patients with ccRCC, ZC3H12C was clearly negatively correlated with Tregs and was significantly positively correlated with monocytes. In addition, protein phosphorylation and DNA methylation analysis also showed that ZC3H12C negatively regulates the role of cancer in ccRCC. Our research may provide new insights into ccRCC immunotherapy and bring forth novel biomarkers and therapeutic targets.", "claims": [{"id": "claim-method", "statement": "In addition, the Kaplan–Meier method and Cox regression were used to evaluate the role of the ZC3H12C expression in KIRC prognosis.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:35795311", "locator": "sections[10] \"2.8. 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