Risk predictive model based on three immune-related gene pairs to assess prognosis and therapeutic sensitivity for hepatocellular carcinoma.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:35932027", "kind": "science-record", "revision": 3, "content_hash": "sha256:6f13077ec96584946adca4ac7cc7ee3fcdca1a6212d77287d534c29944c7728b", "created_at": "2026-11-01T18:15:01Z", "updated_at": "2026-11-01T21:28:33Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Risk predictive model based on three immune-related gene pairs to assess prognosis and therapeutic sensitivity for hepatocellular carcinoma.", "doi": "10.1186/s12957-022-02681-4", "pmid": "35932027", "authors": ["Baifeng Qian", "Haozhong Lin", "Tian Lan", "Muqi Li", "Xiwen Wu", "Shuirong Lin", "Zimin Song", "Shunli Shen", "Baogang Peng"], "journal": "World journal of surgical oncology", "year": 2022, "abstract": "BACKGROUND: Hepatocellular carcinoma (HCC) as a common tumor has a poor prognosis. Recently, a combination of atezolizumab and bevacizumab has been recommended as the preferred regimen for advanced HCC. However, the overall response rate of this therapy is low. There is an urgent need to identify sensitive individuals for this precise therapy among HCC patients.\nMETHODS: The Wilcox test was used to screen the differentially expressed immune-related genes by combining the TCGA cohort and the Immunology Database. Univariate and multivariate Cox regression analysis were used to screen the immune gene pairs concerning prognosis. A predictive model was constructed using LASSO Cox regression analysis, and correlation analysis was conducted between the signature and clinical characteristics. ICGC cohort and GSE14520 were applied for external validations of the predictive risk model. The relationship between immune cell infiltration, TMB, MSI, therapeutic sensitivity of immune checkpoint inhibitors, targeted drugs, and the risk model were assessed by bioinformatics analysis in HCC patients.\nRESULTS: A risk predictive model consisting of 3 immune-related gene pairs was constructed and the risk score was proved as an independent prognostic factor for HCC patients combining the TCGA cohort. This predictive model exhibited a positive correlation with tumor size (p < 0.01) and tumor stage (TNM) (p < 0.001) in the chi-square test. The predictive power was verified by external validations (ICGC and GSE14520). The risk score clearly correlated with immune cell infiltration, MSI, immune checkpoints, and markers of angiogenesis.\nCONCLUSIONS: Our research established a risk predictive model based on 3 immune-related gene pairs and explored its relationship with immune characteristics, which might help to assess the prognosis and treatment sensitivity to immune and targeted therapy of HCC patients.", "claims": [{"id": "claim-method", "statement": "Univariate and multivariate Cox regression analysis were used to screen the immune gene pairs concerning prognosis.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:35932027", "locator": "sections[0] \"Abstract\" paragraph 2", "quote": "Univariate and multivariate Cox regression analysis were used to screen the immune gene pairs concerning prognosis."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The data used in the paper can be downloaded from the public databases (TCGA, ICGC, and GSE14520). If you need more details of analyzing data, please contact the corresponding author.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:35932027", "locator": "sections[24] \"notes\" paragraph 1", "quote": "The data used in the paper can be downloaded from the public databases (TCGA, ICGC, and GSE14520). If you need more details of analyzing data, please contact the corresponding author."}], "state": "complete"}, {"id": "claim-target-result", "statement": "A risk predictive model consisting of 3 immune-related gene pairs was constructed and the risk score was proved as an independent prognostic factor for HCC patients combining the TCGA cohort.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:35932027", "locator": "sections[0] \"Abstract\" paragraph 3", "quote": "A risk predictive model consisting of 3 immune-related gene pairs was constructed and the risk score was proved as an independent prognostic factor for HCC patients combining the TCGA cohort."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "A risk predictive model consisting of 3 immune-related gene pairs was constructed and the risk score was proved as an independent prognostic factor for HCC patients combining the TCGA cohort.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:35932027"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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