LncRNA OR2A1-AS1 index predicts survival in germinal center-like diffuse large B-cell lymphoma.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:36059090", "kind": "science-record", "revision": 4, "content_hash": "sha256:a70c0c60e0b2ae01bc8ec0ff6569a3c25e3afc7215d601cdad0281b1063c4031", "created_at": "2026-11-01T18:15:14Z", "updated_at": "2026-11-01T22:49:58Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "LncRNA OR2A1-AS1 index predicts survival in germinal center-like diffuse large B-cell lymphoma.", "doi": "10.1002/jcla.24680", "pmid": "36059090", "authors": ["Shuting Ye", "Weiwei Ying", "Yi Lin", "Zhengjun Hou", "Meiyun Su"], "journal": "Journal of clinical laboratory analysis", "year": 2022, "abstract": "BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) is a highly aggressive form of non-Hodgkin lymphoma. Long noncoding RNA (lncRNA) has been evaluated as prognostic markers in various carcinomas. However, the prognostic value of the lncRNA index in DLBCL has not been fully understood. Hence, this study aimed to identify the prognostic value of lncRNA olfactory receptor family 2 subfamily A member 1-antisense RNA 1 (OR2A1-AS1) in DLBCL.\nMETHODS: The Gene Expression Omnibus (GEO) database was used to obtain the GSE97336 dataset comprising lncRNA expression profiles. Quantitative reverse transcription polymerase chain reaction (QRT-PCR) was conducted to evaluate the expression of OR2A1-AS1 in 98 cases of DLBCL.\nRESULTS: OR2A1-AS1 expression was considerably reduced in DLBCL patients, reduced OR2A1-AS1 expression was linked to a shorter overall survival (OS) and progression-free survival (PFS) in DLBCL patients, especially those with the germinal center B-cell-like subtype (GCB). Multivariate analysis (MVA) revealed that the OR2A1-AS1 index had prognostic significance. Patients with low OR2A1-AS1 expression have a poor prognosis.\nCONCLUSIONS: OR2A1-AS may represent an effective predictor of patients' outcomes with DLBCL.", "claims": [{"id": "claim-method", "statement": "The Kaplan–Meier method was used to plot the survival curves, and the log‐rank test was carried out to compare them.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:36059090", "locator": "sections[6] \"Statistical analysis\" paragraph 2", "quote": "The Kaplan–Meier method was used to plot the survival curves, and the log‐rank test was carried out to compare them."}], "state": "complete"}, {"id": "claim-data-access", "statement": "Due to the nature of this research, participants of this study did not agree for their data to be shared publicly, so supporting data are not available.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:36059090", "locator": "sections[16] \"DATA AVAILABILITY STATEMENT\" paragraph 2", "quote": "Due to the nature of this research, participants of this study did not agree for their data to be shared publicly, so supporting data are not available."}], "state": "complete"}, {"id": "claim-target-result", "statement": "Lower OR2A1-AS1 expression was associated with shorter overall survival and progression-free survival in DLBCL patients.", "kind": "quantitative", "target": {"value": 0.0058, "unit": "p-value", "tolerance": null, "source": "Those with lower OR2A1‐AS1 expression have a substantially shorter OS and PFS (p = 0.0058 and 0.0023, accordingly) when matched to patients with an elevated OR2A1‐AS1 expression (Figure 3B,C)."}, "evidence": [{"asset": "source:pmid:36059090", "locator": "sections[11] \"Prognosis of OR2A1‐AS1\" paragraph 2", "quote": "Those with lower OR2A1‐AS1 expression have a substantially shorter OS and PFS (p = 0.0058 and 0.0023, accordingly) when matched to patients with an elevated OR2A1‐AS1 expression (Figure 3B,C)."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "Lower OR2A1-AS1 expression was associated with shorter overall survival and progression-free survival in DLBCL patients.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:36059090"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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