Serum albumin, cognitive function, motor impairment, and survival prognosis in Parkinson disease.

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Data were obtained from the publicly available dataset in the DRYAD database (https://datadryad.org/). The original prospective study enrolled patients with PD from a single center in Japan between March 2004 and November 2007. Due to missing values, 242 and 274 participants were included in the study, in which we aimed to, respectively, analyze the relationship between serum albumin and cognitive function as well as motor impairment; additionally, 264 participants were included to assess the association between baseline serum albumin levels and risk of PD-related death with a median follow-up of 5.24 years. Compared to patients of the low tertile of albumin levels, Mini-Mental State Examination (MMSE) of patients of middle tertile increased 2.09 [95% confidence interval (CI) (0.45, 3.73), P = .013], independent of age, sex, PD duration, modified Hoehn-Yahr (mHY) stage, C-reactive protein (CRP) level, and use of nonsteroidal anti-inflammatory drugs (NSAIDs). Further analysis revealed a positive curvilinear association between albumin and MMSE, with cutoff values of 3.9. As concentration serum albumin increased, the risk of severe motor impairment was grown [odds ratio (OR) 0.34 (95% CI 0.14,0.8), P = .013] after adjustment by age, sex, PD duration, MMSE scores, CRP level, and use of NSAIDs. Albumin levels increased per unit of mg/dL, and the risk of PD-related death reduced 0.74-fold with 95% CI (0.15, 0.86) (P = .021), independent of age, sex, PD disease duration, mHY stage, CRP levels, use of NSAIDs, and MMSE. Higher serum albumin levels were significantly association with the better cognitive function when albumin was <3.9 mg/dL, and played a protective role in severe motor impairment and PD-related death.", "claims": [{"id": "claim-method", "statement": "Linear regression analyses were used and partial regression coefficients (Bs) and 95% confidence intervals (CIs) were calculated for cognitive function with serum albumin levels. 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A potential relationship of serum albumin with the risk of PD-related death was also evaluated using Cox regression analyses and hazard ratios (HRs) and 95% CIs were calculated."}], "state": "complete"}, {"id": "claim-data-access", "statement": "Data can be obtained from the DRYAD database (http://www.Datadryad.org).", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:36123949", "locator": "sections[19] \"(untitled)\" paragraph 1", "quote": "Data can be obtained from the DRYAD database (http://www.Datadryad.org)."}], "state": "complete"}, {"id": "claim-target-result", "statement": "Higher serum albumin levels were significantly association with the better cognitive function when albumin was <3.9 mg/dL, and played a protective role in severe motor impairment and PD-related death.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:36123949", "locator": "sections[0] \"Abstract\" paragraph 1", "quote": "Higher serum albumin levels were significantly association with the better cognitive function when albumin was <3.9 mg/dL, and played a protective role in severe motor impairment and PD-related death."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "partial", "objective": "Higher serum albumin levels were significantly association with the better cognitive function when albumin was <3.9 mg/dL, and played a protective role in severe motor impairment and PD-related death.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:36123949"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "blocked", "blocked_on": "data:accession_absent", "description": "The GEO series accession resolves and its sample accessions are listed. 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