The Down-Regulation of Circ_0059707 in Acute Myeloid Leukemia Promotes Cell Growth and Inhibits Apoptosis by Regulating miR-1287-5p.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:36135094", "kind": "science-record", "revision": 3, "content_hash": "sha256:1eb80f6cdb916b96ffabeab0801f3691013af1983e3900789af80ff6f04c4106", "created_at": "2026-11-01T18:15:24Z", "updated_at": "2026-11-01T21:28:59Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "The Down-Regulation of Circ_0059707 in Acute Myeloid Leukemia Promotes Cell Growth and Inhibits Apoptosis by Regulating miR-1287-5p.", "doi": "10.3390/curroncol29090525", "pmid": "36135094", "authors": ["Jichun Ma", "Xiangmei Wen", "Zijun Xu", "Peihui Xia", "Ye Jin", "Jiang Lin", "Jun Qian"], "journal": "Current oncology (Toronto, Ont.)", "year": 2022, "abstract": "Acute myeloid leukemia (AML) is the most common type of hematological malignancy. Recently, an increasing number of reports have shown that many circular RNAs can act as effective targets for AML. However, the roles of circ_0059707 in AML remain largely unclear. In this study, we found that the expression levels of circ_0059707 were significantly decreased in AML patients with respect to normal controls (p < 0.001). Low expression levels of circ_0059707 were also associated with a poor prognosis. Furthermore, circ_0059707 overexpression inhibited cell growth and promoted apoptosis in leukemia cells, compared with control cells. Circ_0059707- and empty plasmid-transfected cells were injected subcutaneously into BALB/c nude mice. We found that the tumor volume was significantly lower in mice in the circ_0059707 group than in control mice (p < 0.01). Nuclear pyknosis, nuclear fragmentation, nuclear dissolution, and cell necrosis were observed in the circ_0059707 group by HE staining. CircInteractome analysis showed that 25 microRNAs (miRNAs), including miR-1287-5p, ©-miR-1825, a©hsa-miR-326, may be potential targets for circ_0059707. The expression of these miRNAs was analyzed in both the GEO GSE51908 and the GSE142700 databases. miR-1287-5p expression was lower in AML patients compared with controls in both the GSE51908 and the GSE142700 datasets. Moreover, we demonstrated that miR-1287-5p expression was down-regulated in AML patients and up-regulated in circ_0059707-overexpressing cells. Collectively, our research demonstrated that the down-regulation of circ_0059707 was highly evident in de novo AML patients. Our analysis also demonstrated that circ_0059707 inhibited cell growth and promoted apoptosis by up-regulating miR-1287-5p.", "claims": [{"id": "claim-method", "statement": "The diagnostic capability of circ_0059707 was analyzed using receiver operating characteristic (ROC) curves and area under the curve (AUC) analysis. Survival was analyzed by the Kaplan–Meier method. Univariate and multivariate data were analyzed by Cox regression. Differences in continuous variables between the two groups were compared by Student’s t-tests.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:36135094", "locator": "sections[11] \"2.9. Statistical Analysis\" paragraph 2", "quote": "The diagnostic capability of circ_0059707 was analyzed using receiver operating characteristic (ROC) curves and area under the curve (AUC) analysis. Survival was analyzed by the Kaplan–Meier method. Univariate and multivariate data were analyzed by Cox regression. Differences in continuous variables between the two groups were compared by Student’s t-tests."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The data presented in this study are available on request from the corresponding author.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:36135094", "locator": "sections[22] \"notes\" paragraph 1", "quote": "The data presented in this study are available on request from the corresponding author."}], "state": "complete"}, {"id": "claim-target-result", "statement": "Collectively, our research demonstrated that the down-regulation of circ_0059707 was highly evident in de novo AML patients. 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