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pmid:36185199
Establishment of lactate-metabolism-related signature to predict prognosis and immunotherapy response in patients with colon adenocarcinoma.
Zhengrong Zou · Yongjie Chai · Qi Li · Xuan Lin · Qingfang He · Qiusheng Xiong
Frontiers in oncology · 2022 doi:10.3389/fonc.2022.958221
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Experiment
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Analysis
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Complete file
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Based on the above background, it is worthwhile to explore novel prognostic and therapeutic biomarkers for COAD patients from the aspect of lactate metabolism. Above all, 228 available lactate-metabolism-related genes (LMRGs) were acquired, and the landscape of copy number variation and the expression difference of mRNA levels between colon normal and tumor samples were investigated among these LMRGs. Importantly, eight overall survival (OS)-involved LMRGs were then distinguished by means of univariate Cox regression analysis in both GSE40967 and TCGA-COAD data sets. Subsequently, prognostic risk scores were established, integrating seven OS-related LMRGs by LASSO Cox regression analysis in the GSE40967 set, and then verified in the TCGA-COAD cohort. From the comprehensive analyses, COAD patients with high risk had comparatively more inferior survival probability in all populations of the study, and they tended to have more severe clinicopathological features with the risk score increasing. Moreover, by integrating age, AJCC T and pathological stage, and risk score, we constructed a prognostic nomogram that demonstrated great prediction effectiveness for OS of COAD patients. Furthermore, the potential effect of various risk score on tumor immune was assessed from enrichment of immune-related pathways, tumor-infiltrating immune cells, and expression levels of immune checkpoints separately. We could draw a conclusion that COAD patients with higher lactate-metabolism-related risk scores may acquire an immunosuppressive tumor microenvironment, which subsequently led to immune escapes and poor prognoses. Conclusively, all findings in the present study illustrate a great prognostic value of the lactate-metabolism-related risk signature, providing more in-depth insights into the indispensable function of lactate metabolism in prognosis and tumor immunity of COAD.", "claims": [{"id": "claim-method", "statement": "To establish a statistically prognostic signature according to these eligible OS-related LMRGs, least absolute shrinkage and selection operator (LASSO) Cox regression analysis was accomplished in the training cohort.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:36185199", "locator": "sections[6] \"Establishment and validation of lactate metabolism–correlated prognostic signature in COAD\" paragraph 2", "quote": "To establish a statistically prognostic signature according to these eligible OS-related LMRGs, least absolute shrinkage and selection operator (LASSO) Cox regression analysis was accomplished in the training cohort."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The original contributions presented in the study are included in the article/ Supplementary Material . 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