Cardiac Alarmins as Residual Risk Markers of Atherosclerosis under Hypolipidemic Therapy.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:36232476", "kind": "science-record", "revision": 5, "content_hash": "sha256:e3d2243238390b82ea112190d91142abf12af8cc3343ada8eab0c64a3385a254", "created_at": "2026-11-01T18:15:36Z", "updated_at": "2026-11-01T22:50:20Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Cardiac Alarmins as Residual Risk Markers of Atherosclerosis under Hypolipidemic Therapy.", "doi": "10.3390/ijms231911174", "pmid": "36232476", "authors": ["Viorel I Suica", "Elena Uyy", "Luminita Ivan", "Raluca M Boteanu", "Aurel Cerveanu-Hogas", "Rune Hansen", "Felicia Antohe"], "journal": "International journal of molecular sciences", "year": 2022, "abstract": "Increased levels of low-density lipoproteins are the main risk factor in the initiation and progression of atherosclerosis. Although statin treatment can effectively lower these levels, there is still a residual risk of cardiovascular events. We hypothesize that a specific panel of stress-sensing molecules (alarmins) could indicate the persistence of silent atherosclerosis residual risk. New Zealand White rabbits were divided into: control group (C), a group that received a high-fat diet for twelve weeks (Au), and a treated hyperlipidemic group with a lipid diet for eight weeks followed by a standard diet and hypolipidemic treatment (atorvastatin and PCSK9 siRNA-inhibitor) for four weeks (Asi). Mass spectrometry experiments of left ventricle lysates were complemented by immunologic and genomic studies to corroborate the data. The hyperlipidemic diet determined a general alarmin up-regulation tendency over the C group. A significant spectral abundance increase was measured for specific heat shock proteins, S100 family members, HMGB1, and Annexin A1. The hypolipidemic treatment demonstrated a reversed regulation trend with non-significant spectral alteration over the C group for some of the identified alarmins. Our study highlights the discriminating potential of alarmins in hyperlipidemia or following hypolipidemic treatment. Data are available via ProteomeXchange with identifier PXD035692.", "claims": [{"id": "claim-method", "statement": "The statistical significance of the quantification ratio comparison was calculated using the ANOVA hypothesis test and corrected using the Benjamini–Hochberg FDR-based algorithm.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:36232476", "locator": "sections[14] \"4.7. 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