NEUROD1 predicts better prognosis in pancreatic cancer revealed by a TILs-based prognostic signature.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:36313290", "kind": "science-record", "revision": 5, "content_hash": "sha256:172bf8fcbcc6f9fd349793d8684a1ee958bae4c0fc3eddaf4040fb0a3ab9479c", "created_at": "2026-11-01T18:15:44Z", "updated_at": "2026-11-01T22:50:30Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "NEUROD1 predicts better prognosis in pancreatic cancer revealed by a TILs-based prognostic signature.", "doi": "10.3389/fphar.2022.1025921", "pmid": "36313290", "authors": ["Zhiyang Jiang", "Jiadong Pan", "Jiahui Lu", "Jie Mei", "Rui Xu", "Dandan Xia", "Xuejing Yang", "Huiyu Wang", "Chaoying Liu", "Junying Xu", "Junli Ding"], "journal": "Frontiers in pharmacology", "year": 2022, "abstract": "It has been well-defined that tumor-infiltrating lymphocytes (TILs) play critical roles in pancreatic cancer (PaCa) progression. This research aimed to comprehensively explore the composition of TILs in PaCa and their potential clinical significance. A total of 178 samples from the TCGA and 63 samples from the GSE57495 dataset were enrolled in our study. ImmuCellAI was applied to calculate the infiltrating abundance of 24 immune cell types in PaCa and further survival analysis revealed the prognostic values of TILs in PaCa. Moreover, the Hallmark enticement analysis of differentially expressed genes (DEGs) between low- and high-risk groups was performed as well. Immunohistochemistry staining was used to evaluate NEUROD1 expression. As result, different kinds of TILs had distinct infiltrating features. In addition, Specific TILs subsets had notable prognostic values in PaCa. We further established a 6-TILs signature to assess the prognosis of PaCa patients. Kaplan-Meier and Cox regression analyses both suggested the significant prognostic value of the signature in PaCa. Based on the prognostic signature, we screened a great deal of potential prognostic biomarkers and successfully validated NEUROD1 as a novel prognostic biomarker in PaCa. Overall, the current study illuminated the immune cells infiltrating the landscape in PaCa and identified a TILs-dependent signature and NEUROD1 for prognostic prediction in PaCa patients.", "claims": [{"id": "claim-method", "statement": "R language was applied to screen differentially expressed genes (DEGs) between low-risk and high-risk samples using the R package “limma”.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:36313290", "locator": "sections[6] \"Identification of differentially expressed genes\" paragraph 2", "quote": "R language was applied to screen differentially expressed genes (DEGs) between low-risk and high-risk samples using the R package “limma”."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The datasets presented in this study can be found in online repositories. The names of the repository/repositories and accession number(s) can be found in the article/Supplementary Material. 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Some preliminary results have already been preprinted online in bioRxiv, doi: https://doi.org/10.1101/2020.03.30.017327."}], "state": "complete"}, {"id": "claim-target-result", "statement": "We further established a 6-TILs signature to assess the prognosis of PaCa patients.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:36313290", "locator": "sections[0] \"Abstract\" paragraph 1", "quote": "We further established a 6-TILs signature to assess the prognosis of PaCa patients."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "We further established a 6-TILs signature to assess the prognosis of PaCa patients.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:36313290"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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