Elafin is related to immune infiltration and could predict the poor prognosis in ovarian cancer.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:36742380", "kind": "science-record", "revision": 2, "content_hash": "sha256:c76193882d233a9eaafe83fe8af8210ad9090870226afb971f26520ddcfc15fe", "created_at": "2026-11-01T19:01:18Z", "updated_at": "2026-11-01T21:30:02Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Elafin is related to immune infiltration and could predict the poor prognosis in ovarian cancer.", "doi": "10.3389/fendo.2023.1088944", "pmid": "36742380", "authors": ["Weiyu Lu", "Biao Xie", "Guangqing Tan", "Wanying Dai", "Jingyi Ren", "Sadaf Pervaz", "Kun Li", "Fangfang Li", "Yingxiong Wang", "Meijiao Wang"], "journal": "Frontiers in endocrinology", "year": 2023, "abstract": "Background: Ovarian cancer (OC) is the most lethal gynecologic malignancy, yet the clinical results for OC patients are still variable. Therefore, we examined how elafin expression affects the patients' prognoses and immunotherapy responses in OC, which may facilitate treatment selection and improve prognosis.\nMethods: The elafin mRNA expression profile was downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus. Elafin's prognostic potential and its relationship with clinical variables were investigated using Kaplan-Meier survival curves, time-dependent receiver operating characteristic curves as well as univariate and multivariate Cox regression models. As validation, protein expression in the tumor and adjacent tissues of OC patients was investigated by using immunohistochemistry (IHC). Comprehensive analyses were then conducted to explore the correlation between immune infiltration and elafin expression.\nResults: A higher mRNA expression of elafin was associated with an unfavorable prognosis in TCGA cohort and was validated in GSE31245 and IHC. Moreover, elafin was indicated as an independent risk factor for OC. A significantly higher protein expression of elafin was detected in the adjacent tissues of OC patients with shorter overall survival (OS). The immune-related pathways were mainly enriched in the high-elafin-mRNA-expression group. However, the mRNA expression of elafin was favorably correlated with indicators of the immune filtration and immunotherapy response, which also proved better immunotherapy outcomes.\nConclusion: The high elafin expression was associated with an unfavorable OS, while it also indicated better immunotherapy responses. Thus, the detection of elafin is beneficial to diagnosis and treatment selection.", "claims": [{"id": "claim-method", "statement": "To validate the prognostic value of elafin, we computed the correlation between gene expression and OS in OC by using the Kaplan–Meier (KM) survival curve.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:36742380", "locator": "sections[5] \"Survival predicted by the expression of elafin and clinical factor\" paragraph 2", "quote": "To validate the prognostic value of elafin, we computed the correlation between gene expression and OS in OC by using the Kaplan–Meier (KM) survival curve."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The original contributions presented in the study are included in the article/ Supplementary Material . Further inquiries can be directed to the corresponding author.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:36742380", "locator": "sections[21] \"Data availability statement\" paragraph 2", "quote": "The original contributions presented in the study are included in the article/ Supplementary Material . Further inquiries can be directed to the corresponding author."}], "state": "complete"}, {"id": "claim-target-result", "statement": "The KM survival curves based on data from TCGA showed that patients in the high-expression group had a shorter 5-year OS than those in the low-expression group (HR = 1.71, 95% CI: 1.27–2.31, P = 0.0004; Figure 2A ).", "kind": "quantitative", "target": {"value": 95.0, "unit": "per cent", "tolerance": null, "source": "The KM survival curves based on data from TCGA showed that patients in the high-expression group had a shorter 5-year OS than those in the low-expression group (HR = 1.71, 95% CI: 1.27–2.31, P = 0.0004; Figure 2A )."}, "evidence": [{"asset": "source:pmid:36742380", "locator": "sections[13] \"Upregulation of elafin was correlated with the poor prognosis for OC\" paragraph 2", "quote": "The KM survival curves based on data from TCGA showed that patients in the high-expression group had a shorter 5-year OS than those in the low-expression group (HR = 1.71, 95% CI: 1.27–2.31, P = 0.0004; Figure 2A )."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "The KM survival curves based on data from TCGA showed that patients in the high-expression group had a shorter 5-year OS than those in the low-expression group (HR = 1.71, 95% CI: 1.27–2.31, P = 0.0004; Figure 2A ).", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:36742380"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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