Elevated ADAM-like Decysin-1 (ADAMDEC1) expression is associated with increased chemo-sensitivity and improved prognosis in breast cancer patients.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:36760254", "kind": "science-record", "revision": 3, "content_hash": "sha256:ce690f287a2ffd441e9a4dbdc232fc7a4e01ecb22e115b238d19393a2212fbbd", "created_at": "2026-11-01T19:01:20Z", "updated_at": "2026-11-01T22:08:45Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Elevated ADAM-like Decysin-1 (ADAMDEC1) expression is associated with increased chemo-sensitivity and improved prognosis in breast cancer patients.", "doi": "10.21037/atm-22-6319", "pmid": "36760254", "authors": ["Na Chai", "Peilin Xie", "Heyan Chen", "Yijun Li", "Yuting Zhao", "Jianjun He", "Huimin Zhang"], "journal": "Annals of translational medicine", "year": 2023, "abstract": "Background: Chemoresistance is problematic and its mechanisms are unclear in breast cancer. More predictive markers are urgently required.\nMethods: GSE32646, GSE34138, and GSE20271 were downloaded from the Gene Expression Omnibus (GEO) database to identify differentially expressed genes (DEGs) between chemosensitive and chemoresistant tumors. LinkedOmics was used to analyze ADAM-like Decysin-1 (ADAMDEC1) expression among patients with different clinical characteristics and detect co-expression genes for functional analysis. Tumor Immune Estimation Resource (TIMER) and an integrated repository portal for tumor-immune system interactions (TISIDB) were used to investigate the association between the target gene and the immune response. Gene Set Cancer Analysis (GSCA) was utilized to explore the related pathways of ADAMDEC1 and evaluate the correlation between the expression of ADAMDEC1 and drug sensitivity. RNA22, miRWalk, and miRmap were used to predict the upstream micro ribonucleic acids (miRNAs) regulating ADAMDEC1 expression, while DIANA-LncBase v2 was applied to predict the upstream long non-coding ribonucleic acids (lncRNAs). Kaplan-Meier curve analysis was applied to determine the survival time.\nResults: We identified that ADAMDEC1 was upregulated among chemosensitive triple-negative breast cancer (TNBC) tissues in GSE32646, GSE34138, and GSE20271. Higher expression of ADAMDEC1 indicated longer survival in breast cancer. Next, we found that ADAMDEC1 was significantly related to the immune response in breast cancer through functional enrichment analysis and further meta-data validation. Moreover, we recognized that hsa-miR-4534 was the potential upstream miRNA regulating ADAMDEC1 expression and Taurine Up-Regulated 1 (TUG1) was the most likely upstream lncRNA of ADAMDEC1 and hsa-miR-4534. Finally, the correlation between ADAMDEC1 and chemosensitivity was confirmed through drug database analysis.\nConclusions: Elevated ADAMDEC1 expression is associated with increased chemosensitivity and better prognosis in breast cancer patients.", "claims": [{"id": "claim-method", "statement": "Also, we further investigated the DEGs by comparing chemosensitive and chemoresistant TNBC tumors using the GEO2R online analysis tool. DEGs were defined as genes that met the cut-off criteria of |log2 fold change| >1 (|logFC| >1) and P<0.05.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:36760254", "locator": "sections[4] \"Data source\" paragraph 2", "quote": "Also, we further investigated the DEGs by comparing chemosensitive and chemoresistant TNBC tumors using the GEO2R online analysis tool. DEGs were defined as genes that met the cut-off criteria of |log2 fold change| >1 (|logFC| >1) and P<0.05."}], "state": "complete"}, {"id": "claim-data-access", "statement": "GSE32646, GSE34138, and GSE20271 were downloaded from the Gene Expression Omnibus (GEO) database to identify differentially expressed genes (DEGs) between chemosensitive and chemoresistant tumors.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:36760254", "locator": "sections[0] \"Abstract\" paragraph 2", "quote": "GSE32646, GSE34138, and GSE20271 were downloaded from the Gene Expression Omnibus (GEO) database to identify differentially expressed genes (DEGs) between chemosensitive and chemoresistant tumors."}], "state": "complete"}, {"id": "claim-target-result", "statement": "Elevated ADAMDEC1 expression is associated with increased chemosensitivity and better prognosis in breast cancer patients.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:36760254", "locator": "sections[0] \"Abstract\" paragraph 4", "quote": "Elevated ADAMDEC1 expression is associated with increased chemosensitivity and better prognosis in breast cancer patients."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "Elevated ADAMDEC1 expression is associated with increased chemosensitivity and better prognosis in breast cancer patients.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:36760254"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. This lane did not download the dataset or read its licence.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE20271"], "outputs": ["the source data with its repository provenance"], "instruments": [], "reagents": []}, {"id": "run_analysis", "order": 3, "name": "Run the published analysis", "kind": "analysis", "state": "complete", "blocked_on": null, "description": "Apply the paper's statistical method to the resolved series and compare the result with the published target.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE20271"], "outputs": ["the replicated result and its comparison"], "instruments": [], "reagents": []}], "materials": [], "instruments": [], "reagents": [], "conditions": {}, "gaps": []}, "data": {"state": "partial", "assets": [{"id": "source:pmid:36760254", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.21037/atm-22-6319", "sha256": 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