A comprehensive computational analysis to explore the importance of SIGLECs in HCC biology.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:36803349", "kind": "science-record", "revision": 3, "content_hash": "sha256:32721ca9ceb4273906dbcc1cd6221c6d26d99bceca3917e53870065cfd9fd082", "created_at": "2026-11-01T19:01:23Z", "updated_at": "2026-11-01T22:08:50Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "A comprehensive computational analysis to explore the importance of SIGLECs in HCC biology.", "doi": "10.1186/s12876-023-02672-z", "pmid": "36803349", "authors": ["Senbang Yao", "Wenjun Chen", "Tingting Chen", "He Zuo", "Ziran Bi", "Xiuqing Zhang", "Lulian Pang", "Yanyan Jing", "Xiangxiang Yin", "Huaidong Cheng"], "journal": "BMC gastroenterology", "year": 2023, "abstract": "BACKGROUND: Hepatocellular carcinoma (HCC) is an aggressive, malignant cancer with a complex pathogenesis. However, effective therapeutic targets and prognostic biomarkers are limited. Sorafenib provides delaying cancer progression and survival improvement in advanced HCC. But despite 10 years of research on the clinical application of sorafenib, predictive markers for its therapeutic effect are lacking.\nMETHODS: The clinical significance and molecular functions of SIGLEC family members were assessed by a comprehensive bioinformatic analysis. The datasets included in this study (ICGC-LIRI-JP, GSE22058 and GSE14520) are mainly based on patients with HBV infections or HBV-related liver cirrhosis. The TCGA, GEO, and HCCDB databases were used to explore the expression of SIGLEC family genes in HCC. The Kaplan-Meier Plotter database was used to evaluate relationships between the expression levels of SIGLEC family genes and prognosis. Associations between differentially expressed genes in the SIGLEC family and tumour-associated immune cells were evaluated using TIMER.\nRESULTS: The mRNA levels of most SIGLEC family genes were significantly lower in HCC than in normal tissues. Low protein and mRNA expression levels of SIGLECs were strongly correlated with tumour grade and clinical cancer stage in patients with HCC. Tumour-related SIGLEC family genes were associated with tumour immune infiltrating cells. High SIGLEC expression was significantly related to a better prognosis in patients with advanced HCC treated with sorafenib.\nCONCLUSIONS: SIGLEC family genes have potential prognostic value in HCC and may contribute to the regulation of cancer progression and immune cell infiltration. More importantly, our results revealed that SIGLEC family gene expression may be used as a prognostic marker for HCC patients treated with sorafenib.", "claims": [{"id": "claim-method", "statement": "A Kaplan–Meier survival analysis was performed to contrast two patient cohorts. The HR with 95% confidence interval and log-rank P value were assessed.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:36803349", "locator": "sections[7] \"Survival and mutation analysis of SIGLEC in HCC\" paragraph 3", "quote": "A Kaplan–Meier survival analysis was performed to contrast two patient cohorts. The HR with 95% confidence interval and log-rank P value were assessed."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The datasets analysed in this research are available from the corresponding author.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:36803349", "locator": "sections[27] \"notes\" paragraph 1", "quote": "The datasets analysed in this research are available from the corresponding author."}], "state": "complete"}, {"id": "claim-target-result", "statement": "High SIGLEC expression was associated with a better prognosis in patients with advanced HCC treated with sorafenib.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:36803349", "locator": "sections[0] \"Abstract\" paragraph 3", "quote": "High SIGLEC expression was significantly related to a better prognosis in patients with advanced HCC treated with sorafenib."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "partial", "objective": "High SIGLEC expression was associated with a better prognosis in patients with advanced HCC treated with sorafenib.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:36803349"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "blocked", "blocked_on": "data:accession_absent", "description": "The GEO series accession resolves and its sample accessions are listed. 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