A hybrid systems biology and systems pharmacology investigation of Zingerone's effects on reconstructed human epidermal tissues.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:36820091", "kind": "science-record", "revision": 2, "content_hash": "sha256:e94ef436460b5a97adc42224ed70d00d853c4630c2418f7362c23835b35a5730", "created_at": "2026-11-01T19:01:25Z", "updated_at": "2026-11-01T21:30:12Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "A hybrid systems biology and systems pharmacology investigation of Zingerone's effects on reconstructed human epidermal tissues.", "doi": "10.1186/s43042-021-00204-6", "pmid": "36820091", "authors": ["Elham Amjad", "Babak Sokouti", "Solmaz Asnaashari"], "journal": "The Egyptian journal of medical human genetics", "year": 2021, "abstract": "Background: As individuals live longer, elderly populations can be expected to face issues. This pattern urges researchers to investigate the aging concept further to produce successful anti-aging agents. In the current study, the effects of Zingerone (a natural compound) on epidermal tissues were analyzed using a bioinformatics approach.\nMethods: For this purpose, we chose the GEO dataset GSE133338 to carry out the systems biology and systems pharmacology approaches, ranging from identifying the differentially expressed genes to analyzing the gene ontology, determining similar structures of Zingerone and their features (i.e., anti-oxidant, anti-inflammatory, and skin disorders), constructing the gene-chemicals network, analyzing gene-disease relationships, and validating significant genes through the evidence presented in the literature.\nResults: The post-processing of the microarray dataset identified thirteen essential genes among control and Zingerone-treated samples. The procedure revealed various structurally similar chemical and herbal compounds with possible skin-related effects. Additionally, we studied the relationships of differentially expressed genes with skin-related diseases and validated their direct connections with skin disorders the evidence available in the literature. Also, the analysis of the microarray profiling dataset revealed the critical role of interleukins as a part of the cytokines family on skin aging progress.\nConclusions: Zingerone, and potentially any constituents of Zingerone (e.g., their similar compound scan functionality), can be used as therapeutic agents in managing skin disorders such as skin aging. However, the beneficial effects of Zingerone should be assessed in other models (i.e., human or animal) in future studies.", "claims": [{"id": "claim-method", "statement": "The data preprocessing and class comparison approach using a two-sample t test revealed a total of sixty probe IDs, from which only thirteen DEGs were available as annotated genes.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:36820091", "locator": "sections[8] \"Results\" paragraph 2", "quote": "The data preprocessing and class comparison approach using a two-sample t test revealed a total of sixty probe IDs, from which only thirteen DEGs were available as annotated genes."}], "state": "complete"}, {"id": "claim-data-access", "statement": "Not applicable.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:36820091", "locator": "sections[16] \"notes\" paragraph 1", "quote": "Not applicable."}], "state": "complete"}, {"id": "claim-target-result", "statement": "Also, the analysis of the microarray profiling dataset revealed the critical role of interleukins as a part of the cytokines family on skin aging progress.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:36820091", "locator": "sections[0] \"Abstract\" paragraph 3", "quote": "Also, the analysis of the microarray profiling dataset revealed the critical role of interleukins as a part of the cytokines family on skin aging progress."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "Also, the analysis of the microarray profiling dataset revealed the critical role of interleukins as a part of the cytokines family on skin aging progress.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:36820091"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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