A Novel 7-Methylguanosine (m7G)-Related Gene Signature for Overall Survival Prediction in Patient with Clear Cell Renal Cell Carcinoma.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:37089261", "kind": "science-record", "revision": 2, "content_hash": "sha256:7900359972f0a7799f2fbab85c3234c5fa86f47d47568c570e62f5ab4005acb8", "created_at": "2026-11-01T19:01:45Z", "updated_at": "2026-11-01T21:30:36Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "A Novel 7-Methylguanosine (m7G)-Related Gene Signature for Overall Survival Prediction in Patient with Clear Cell Renal Cell Carcinoma.", "doi": "10.1155/2023/9645038", "pmid": "37089261", "authors": ["Yongxin Fu", "Jiawu Wang", "Zhiya Hu", "Yang Gou", "Yisen Li", "Qing Jiang"], "journal": "Journal of oncology", "year": 2023, "abstract": "Clear cell renal cell carcinoma (ccRCC) is the most common pathology type of renal cancer that has an abysmal prognosis. Although a crucial role for 7-methylguanosine modification in cancer cell development has been reported, its role in ccRCC remains uncertain. This study was conducted to determine the efficacy of predictive biomarkers based on m7G-related genes in ccRCC. Firstly, we extracted clinical data and gene expression profiles of ccRCC patients from publicly accessible databases. It identified that 22 of the m7G-related 34 genes were related to overall survival, and 5 of the 22 genes were significantly expressed differently in tumor tissues. Based on Lasso regression analysis, five optimal genes (CYFIP2, EIF4A1, NUDT1, NUDT10, and NUDT4) were chosen to build a new predictive risk model in the TCGA cohort. Validation was carried out with the E-MTAB-1980 cohort. Then, a prognostic nomogram was erected, including the m7G-related gene risk score, age, histological grade, and stage status. Further studies and analysis showed that immune cell infiltration might be associated with the m7G-related risk genes. In addition, the relationship between gene expression and drug response was evaluated by the Pearson correlation test. Therefore, the risk signature with five selected m7G-related genes may be a promising prognostic biomarker and contribute to standardized prognostic assessment for ccRCC.", "claims": [{"id": "claim-data-access", "statement": "All datasets are publicly available, and we can find all datasets here: https://portal.gdc.cancer.gov/and https://www.ebi.ac.uk/arrayexpress.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:37089261", "locator": "sections[20] \"Data Availability\" paragraph 2", "quote": "All datasets are publicly available, and we can find all datasets here: https://portal.gdc.cancer.gov/and https://www.ebi.ac.uk/arrayexpress."}], "state": "complete"}, {"id": "claim-target-result", "statement": "The area under the curve (AUC) was 0.617 at 1 year, at 2 years it reached 0.622, and at 3 years it reached 0.659.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:37089261", "locator": "sections[12] \"3.3. 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