GBP5 Identifies Immuno-Hot Tumors and Predicts the Therapeutic Response to Immunotherapy in NSCLC.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:37193249", "kind": "science-record", "revision": 2, "content_hash": "sha256:cdba87c949df1970308a3425fdaed5f85e641fbccbc356f999d8e596c0d0e515", "created_at": "2026-11-01T19:01:53Z", "updated_at": "2026-11-01T21:30:46Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "GBP5 Identifies Immuno-Hot Tumors and Predicts the Therapeutic Response to Immunotherapy in NSCLC.", "doi": "10.2147/IJGM.S408900", "pmid": "37193249", "authors": ["Honghong Fan", "Yuxin Shi", "Huiyu Wang", "Yuting Li", "Jie Mei", "Junying Xu", "Chaoying Liu"], "journal": "International journal of general medicine", "year": 2023, "abstract": "Background: Immunotherapy drugs, immune checkpoint inhibitors (ICIs), have been approved for first- and second-line treatment of non-small cell lung cancer (NSCLC), but only a portion of patients respond to ICIs. It is crucial to screen the beneficiaries of immunotherapy through biomarkers accurately.\nMethods: Several datasets were used to explore the predictive value for immunotherapy and immune relevance of guanylate binding protein 5 (GBP5) in NSCLC, including the GSE126044 dataset, The Cancer Genome Atlas (TCGA) dataset, Clinical Proteomic Tumor Analysis Consortium (CPTAC) dataset, the Kaplan-Meier plotter dataset, the HLuA150CS02 cohort, and the HLugS120CS01 cohort.\nResults: GBP5 was upregulated in tumor tissues but associated with a good prognosis in NSCLC. Moreover, our findings demonstrated that GBP5 was strongly correlated with the expression of many immune-related genes, TIIC levels, and PD-L1 expression based on RNA-seq data onto online databases and validation of the NSCLC tissue microarray using IHC staining. Moreover, pan-cancer analysis has shown that GBP5 was a factor in identifying immuno-hot tumors, except for a few tumor types.\nConclusion: In summary, our current research suggests that GBP5 expression is a potential biomarker for predicting the outcome of NSCLC patients treated with ICIs. More research with large-scale samples is needed to determine their value as biomarkers of ICIs benefit.", "claims": [{"id": "claim-method", "statement": "Survival analysis was performed by Log rank test.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:37193249", "locator": "sections[9] \"Statistical Analysis\" paragraph 2", "quote": "Survival analysis was performed by Log rank test."}], "state": "complete"}, {"id": "claim-data-access", "statement": "All data supporting the results of this study are shown in this published article and Supplementary Documents. In addition, original omics data for bioinformatics analysis could be obtained from corresponding platforms.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:37193249", "locator": "sections[18] \"Data Sharing Statement\" paragraph 2", "quote": "All data supporting the results of this study are shown in this published article and Supplementary Documents. In addition, original omics data for bioinformatics analysis could be obtained from corresponding platforms."}], "state": "complete"}, {"id": "claim-target-result", "statement": "Patients with upregulated GBP5 expression had better overall survival (OS) (P=0.013, HR=0.81) and post-progression survival (PPS) (P=0.016, HR=0.59) than those with low expression, suggesting a better prognosis for NSCLC patients.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:37193249", "locator": "sections[11] \"Expression and Prognostic Value of GBP5 in NSCLC\" paragraph 2", "quote": "We discovered that patients with upregulated GBP5 expression had better overall survival (OS) (P=0.013, HR=0.81) (Figure 1E) and post-progression survival (PPS) (P=0.016, HR=0.59) (Figure 1F) than those with low expression, suggesting a better prognosis for NSCLC patients."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "Patients with upregulated GBP5 expression had better overall survival (OS) (P=0.013, HR=0.81) and post-progression survival (PPS) (P=0.016, HR=0.59) than those with low expression, suggesting a better prognosis for NSCLC patients.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:37193249"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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