Prognostic and immunological potential of PPM1G in lung adenocarcinoma.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:37387407", "kind": "science-record", "revision": 4, "content_hash": "sha256:d6c6129247266434f1d6ce618b85f6a5e228a004c4211d101c2ef3e0acd82d58", "created_at": "2026-11-01T19:02:08Z", "updated_at": "2026-11-01T22:52:14Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Prognostic and immunological potential of PPM1G in lung adenocarcinoma.", "doi": "10.3892/mmr.2023.13043", "pmid": "37387407", "authors": ["Rongjiang Yin", "Li Qu", "Zhanqing Wang", "Jian Tang", "Hua Gu", "Xiaohui Wang", "Donglin Yang", "Pengchao Du", "Menghua Dong"], "journal": "Molecular medicine reports", "year": 2023, "abstract": "Lung cancer is one of the most common types of cancer worldwide, with the highest incidence and mortality rates. Protein phosphatase, Mg2+/Mn2+ dependent 1G (PPM1G) is a serine/threonine phosphatase, which is involved in the proliferation, invasion and metastasis of tumor cells. However, there are few reports on the role of PPM1G in lung adenocarcinoma (LUAD). The present study used publicly available data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus databases to evaluate the expression of PPM1G in LUAD, and to assess the relationship between PPM1G expression and the prognosis of patients with LUAD. Protein expression data of PPM1G obtained by immunohistochemical staining were collected from the Human Protein Atlas database. The correlation between PPM1G and immune cell infiltration and immune checkpoints was analyzed by single‑sample gene set enrichment analysis of TCGA data. The Kaplan‑Meier method was used for survival analysis, and univariate and multivariate Cox regression were used to analyze the effect of PPM1G on prognosis with data from TCGA database. The results showed that PPM1G was highly expressed in LUAD cancer tissues. The high expression of PPM1G was associated with poor clinical stage, T stage, N stage and overall survival in LUAD. The present study screened 29 genes related to PPM1G and closely related to the cell cycle in patients with LUAD. The expression of PPM1G was positively correlated with γδ‑Τ cells, T helper 2 cells and natural killer CD56dim cells, and was negatively correlated with B cells, mast cells, plasmacytoid dendritic cells, T helper cells, macrophages, T cells, CD8 T cells, central memory T cells, effector memory T cells, neutrophils and T follicular helper cells. In addition, PPM1G was positively correlated with immune detection points. In conclusion, PPM1G may be involved in the control of the lung cancer cell cycle, and could be associated with prognosis and immune infiltration in patients with LUAD.", "claims": [{"id": "claim-method", "statement": "The Kaplan-Meier method was used for survival analysis, and univariate and multivariate Cox regression were used to analyze the effect of PPM1G on prognosis with data from TCGA database.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:37387407", "locator": "sections[0] \"Abstract\" paragraph 1", "quote": "The Kaplan-Meier method was used for survival analysis, and univariate and multivariate Cox regression were used to analyze the effect of PPM1G on prognosis with data from TCGA database."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The datasets used and/or analyzed during the current study available from the corresponding author on reasonable request.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:37387407", "locator": "sections[25] \"Availability of data and materials\" paragraph 2", "quote": "The datasets used and/or analyzed during the current study available from the corresponding author on reasonable request."}], "state": "complete"}, {"id": "claim-target-result", "statement": "Kaplan-Meier survival analysis revealed that high PPM1G expression was associated with poor prognosis in patients with LUAD (HR=1.82; P<0.001; Fig. 4A).", "kind": "quantitative", "target": {"value": 1.82, "unit": "hazard ratio", "tolerance": null, "source": "Kaplan-Meier survival analysis revealed that high PPM1G expression was associated with poor prognosis in patients with LUAD (HR=1.82; P<0.001; Fig. 4A)."}, "evidence": [{"asset": "source:pmid:37387407", "locator": "sections[17] \"High PPM1G expression is an independent prognostic factor for OS in LUAD\" paragraph 2", "quote": "Kaplan-Meier survival analysis revealed that high PPM1G expression was associated with poor prognosis in patients with LUAD (HR=1.82; P<0.001; Fig. 4A)."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "Kaplan-Meier survival analysis revealed that high PPM1G expression was associated with poor prognosis in patients with LUAD (HR=1.82; P<0.001; Fig. 4A).", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:37387407"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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