Serum HSF1 is upregulated in endometriosis patients and serves as a potential diagnostic biomarker.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:37409787", "kind": "science-record", "revision": 2, "content_hash": "sha256:487bc44e881cca48d0dee48c88ff05cf01a268d829e64455ddf0f9d10feb8f26", "created_at": "2026-11-01T19:02:10Z", "updated_at": "2026-11-01T21:31:07Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Serum HSF1 is upregulated in endometriosis patients and serves as a potential diagnostic biomarker.", "doi": "10.1002/kjm2.12723", "pmid": "37409787", "authors": ["Hui-Ying Pan", "Jing Wan"], "journal": "The Kaohsiung journal of medical sciences", "year": 2023, "abstract": "Endometriosis (EMS) is a prevalent gynecological condition lacking reliable diagnostic biomarkers. This prospective study aimed to analyze the potential of serum heat shock transcription factor 1 (HSF1) as a diagnostic marker for EMS. Clinical features of 92 EMS patients and 52 controls were recorded, revealing significant differences in dysmenorrhea, dyspareunia, pelvic pain, nulliparity, and CA125 levels. Serum HSF1 was upregulated in EMS patients, with higher levels in American Society for Reproductive Medicine (ASRM) III/IV than ASRM I/II. Receiver operating characteristic curve analysis demonstrated good diagnostic function for serum HSF1 (AUC: 0.857, sensitivity: 91.30%, specificity: 63.46%). Serum HSF1, dysmenorrhea, dyspareunia, and nulliparity were independent risk factors for EMS, while dysmenorrhea and serum HSF1 were independent risk factors for EMS severity. Additionally, the GSE25628 dataset was downloaded from the GEO database for differential analysis of gene expression. The HSF1 downstream target genes PTGES3, HSP90AA1, and HSPB1 showed significant differential expression in EMS, suggesting their involvement in the regulatory mechanism of HSF1 in EMS.", "claims": [{"id": "claim-method", "statement": "Receiver operating characteristic (ROC) analysis was conducted to evaluate the diagnostic accuracy of serum HSF1 for EMS patients.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:37409787", "locator": "sections[8] \"Statistical analysis\" paragraph 2", "quote": "Receiver operating characteristic (ROC) analysis was conducted to evaluate the diagnostic accuracy of serum HSF1 for EMS patients."}], "state": "complete"}, {"id": "claim-data-access", "statement": "We downloaded the EMS dataset GSE25628, which includes eight cases of ectopic endometria from EMS patients and 6 cases of endometria from healthy women, from the Gene Expression Omnibus (GEO) database.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:37409787", "locator": "sections[7] \"Bioinformatics\" paragraph 2", "quote": "We downloaded the EMS dataset GSE25628, which includes eight cases of ectopic endometria from EMS patients and 6 cases of endometria from healthy women, from the Gene Expression Omnibus (GEO) database."}], "state": "complete"}, {"id": "claim-target-result", "statement": "Based on ROC analysis, the cutoff value of serum HSF1 in EMS was 1.12 (area under the curve [AUC]: 0.857), with a sensitivity and specificity of 91.30% and 63.46%, respectively (p < 0.05, Figure 1C).", "kind": "quantitative", "target": {"value": 0.05, "unit": "p-value", "tolerance": null, "source": "Based on ROC analysis, the cutoff value of serum HSF1 in EMS was 1.12 (area under the curve [AUC]: 0.857), with a sensitivity and specificity of 91.30% and 63.46%, respectively (p < 0.05, Figure 1C)."}, "evidence": [{"asset": "source:pmid:37409787", "locator": "sections[11] \"Determination of serum HSF1 and its diagnostic value\" paragraph 2", "quote": "Based on ROC analysis, the cutoff value of serum HSF1 in EMS was 1.12 (area under the curve [AUC]: 0.857), with a sensitivity and specificity of 91.30% and 63.46%, respectively (p < 0.05, Figure 1C)."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "Based on ROC analysis, the cutoff value of serum HSF1 in EMS was 1.12 (area under the curve [AUC]: 0.857), with a sensitivity and specificity of 91.30% and 63.46%, respectively (p < 0.05, Figure 1C).", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:37409787"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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