Identification of TRPM2 as a prognostic factor correlated with immune infiltration in ovarian cancer.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:37608401", "kind": "science-record", "revision": 3, "content_hash": "sha256:33b67ed687fd10a835b6a409ab94c3d00cb9e439a869903036e5b14ea2c72eac", "created_at": "2026-11-01T19:02:24Z", "updated_at": "2026-11-01T22:52:34Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Identification of TRPM2 as a prognostic factor correlated with immune infiltration in ovarian cancer.", "doi": "10.1186/s13048-023-01225-y", "pmid": "37608401", "authors": ["Wei Huang", "Yuliang Wu", "Ning Luo", "Xueqian Shuai", "Jing Guo", "Chunyan Wang", "Fanchun Yang", "Li Liu", "Shupeng Liu", "Zhongping Cheng"], "journal": "Journal of ovarian research", "year": 2023, "abstract": "INTRODUCTION: Ovarian cancer (OC) is one of the most common gynecologic malignant cancers with the current survival rate remaining low. TRPM2 has been reported as a survival predictor in various cancers but not in OC. The aim of this study is to explore the role and its underlying mechanism of TRPM2 in OC.\nMETHODS: The transcriptome data and clinical data were obtained from TCGA, GTEx, and GEO (GSE17260). DriverDBv3 and PrognoScan were used to analyze survival correlations. GSEA analysis was performed to uncover the underlying mechanism. The correlations between TRPM2 and immune score, immune cell infiltration were analyzed by TIMER2.0.\nRESULTS: TRPM2 was highly expressed in OC and high TRPM2 expression was related to the poor prognosis based on the Kaplan-Meier curves, univariate and multivariate analysis. The enrichment analysis suggested that TRPM2 was involved in immune-related pathways. Positive correlations were also observed between TRPM2 expression and immune score and immune cells covering B cells, T cells, macrophage, neutrophil, and myeloid dendritic cells. We also found that TRPM2 was positively related to immune checkpoints including ICOSLG, CD40, CD86, etc. TRPM2 expression had a positive correlation with M2 macrophage, but not with M1 macrophage. Besides, TRPM2 showed a strong positive correlation with pyroptosis-related genes including NLRP3, NLRC4, NOD2, NOD1, IL1B, GSDMD.\nCONCLUSION: Our study demonstrated that TRPM2 is a poor prognostic prediction factor in ovarian cancer and is correlated to the immune microenvironment and pyroptosis. TRPM2 may act as a new immunotherapy target, which promoted the survival rate of OC patients.", "claims": [{"id": "claim-method", "statement": "In survival analysis, the HRs and p-values were estimated by univariate Cox regression analysis. Kaplan-Meier curves was used to analyze the survival of patients stratified based on different levels of TRMR2 expression. All correlation analyses were adopted by coefficient Pearson.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:37608401", "locator": "sections[18] \"Statistical analysis\" paragraph 2", "quote": "In survival analysis, the HRs and p-values were estimated by univariate Cox regression analysis. Kaplan-Meier curves was used to analyze the survival of patients stratified based on different levels of TRMR2 expression. All correlation analyses were adopted by coefficient Pearson."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The tumor mRNA and clinical data were obtained from The Cancer Genome Atlas (TCGA), a database containing more than 20,000 primary samples and non-cancer samples from 33 types of cancer (https://cancergenome.nih.gov/) [39].", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:37608401", "locator": "sections[11] \"Data collection\" paragraph 2", "quote": "The tumor mRNA and clinical data were obtained from The Cancer Genome Atlas (TCGA), a database containing more than 20,000 primary samples and non-cancer samples from 33 types of cancer (https://cancergenome.nih.gov/) [39]."}], "state": "complete"}, {"id": "claim-target-result", "statement": "TRPM2 was a poor prognostic predictor in ovarian cancer and was correlated with the immune microenvironment and pyroptosis.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:37608401", "locator": "sections[0] \"Abstract\" paragraph 4", "quote": "Our study demonstrated that TRPM2 is a poor prognostic prediction factor in ovarian cancer and is correlated to the immune microenvironment and pyroptosis."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "TRPM2 was a poor prognostic predictor in ovarian cancer and was correlated with the immune microenvironment and pyroptosis.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:37608401"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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